Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ERBB3 Gene

Aliases for ERBB3 Gene

  • Erb-B2 Receptor Tyrosine Kinase 3 2 3
  • V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3 2 3
  • Tyrosine Kinase-Type Cell Surface Receptor HER3 3 4
  • Human Epidermal Growth Factor Receptor 3 2 3
  • Proto-Oncogene-Like Protein C-ErbB-3 3 4
  • EC 4 63
  • LCCS2 3 6
  • HER3 3 4
  • Lethal Congenital Contracture Syndrome 2 2
  • Receptor Tyrosine-Protein Kinase ErbB-3 3
  • P180-ErbB3 3
  • P45-SErbB3 3
  • P85-SErbB3 3
  • EC 2.7.10 63
  • MDA-BF-1 3
  • C-ErbB-3 3
  • C-ErbB3 3
  • ErbB3-S 3
  • ErbB-3 3

External Ids for ERBB3 Gene

Previous HGNC Symbols for ERBB3 Gene

  • LCCS2

Previous GeneCards Identifiers for ERBB3 Gene

  • GC12M056386
  • GC12M056841
  • GC12P056190
  • GC12P054760
  • GC12P056473
  • GC12P053512

Summaries for ERBB3 Gene

Entrez Gene Summary for ERBB3 Gene

  • This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for ERBB3 Gene

ERBB3 (Erb-B2 Receptor Tyrosine Kinase 3) is a Protein Coding gene. Diseases associated with ERBB3 include lethal congenital contractural syndrome 2 and gestational trophoblastic tumor. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is TNK1.

UniProtKB/Swiss-Prot for ERBB3 Gene

  • Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5.

Tocris Summary for ERBB3 Gene

  • The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4). EGFR signaling is initiated by ligand binding to the extracellular ligand binding domain. This initiates receptor homo-/hetero-dimerization and autophosphorylation by the intracellular kinase domain, resulting in receptor activation. Following activation, phosphorylation of cytoplasmic substrates occurs and a signaling cascade is initiated that drives many cellular responses, including changes in gene expression, cytoskeletal rearrangement, anti-apoptosis and increased cell proliferation.

Gene Wiki entry for ERBB3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERBB3 Gene

Genomics for ERBB3 Gene

Regulatory Elements for ERBB3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ERBB3 Gene

56,079,857 bp from pter
56,103,507 bp from pter
23,651 bases
Plus strand

Genomic View for ERBB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ERBB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERBB3 Gene

Proteins for ERBB3 Gene

  • Protein details for ERBB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor tyrosine-protein kinase erbB-3
    Protein Accession:
    Secondary Accessions:
    • A8K6L6
    • B4DIK7
    • B4DV32
    • E9PDT8
    • Q9BUD7

    Protein attributes for ERBB3 Gene

    1342 amino acids
    Molecular mass:
    148098 Da
    Quaternary structure:
    • Monomer and homodimer. Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5, GRB7, and MUC1. Interacts with MYOC (By similarity). Interacts with isoform 2 of PA2G4.

    Three dimensional structures from OCA and Proteopedia for ERBB3 Gene

    Alternative splice isoforms for ERBB3 Gene


neXtProt entry for ERBB3 Gene

Proteomics data for ERBB3 Gene at MOPED

Post-translational modifications for ERBB3 Gene

  • Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (By similarity). Subject to autophosphorylation.
  • Glycosylation at Asn126, Asn250, Asn353, Asn408, Asn414, Asn437, Asn469, Asn522, Asn566, and Asn616
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ERBB3 (HER3)

Protein Products

Domains for ERBB3 Gene

Graphical View of Domain Structure for InterPro Entry



  • P21860
  • The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
genes like me logo Genes that share domains with ERBB3: view

Function for ERBB3 Gene

Molecular function for ERBB3 Gene

GENATLAS Biochemistry:
avian erythroblastic leukemia,viral (v-erb-b) oncogene homolog 3,heregulin beta 1 receptor,signal transducer receptor,heterodimerizing with the ligand less recetpor ERBB2
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5.

Enzyme Numbers (IUBMB) for ERBB3 Gene

Gene Ontology (GO) - Molecular Function for ERBB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 NOT protein tyrosine kinase activity IDA 7556068
GO:0004714 transmembrane receptor protein tyrosine kinase activity --
GO:0004716 receptor signaling protein tyrosine kinase activity --
GO:0004888 transmembrane signaling receptor activity ISS 7514177
genes like me logo Genes that share ontologies with ERBB3: view
genes like me logo Genes that share phenotypes with ERBB3: view

Animal Models for ERBB3 Gene

MGI Knock Outs for ERBB3:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ERBB3

Clone Products

  • Addgene plasmids for ERBB3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for ERBB3 Gene

Localization for ERBB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERBB3 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

Jensen Localization Image for ERBB3 Gene COMPARTMENTS Subcellular localization image for ERBB3 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 3
nucleus 2
cytosol 1
endoplasmic reticulum 1
endosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ERBB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 11389077
GO:0005886 plasma membrane TAS 17701904
GO:0005887 integral component of plasma membrane TAS 2687875
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with ERBB3: view

Pathways for ERBB3 Gene

genes like me logo Genes that share pathways with ERBB3: view

PCR Array Products

Gene Ontology (GO) - Biological Process for ERBB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003197 endocardial cushion development IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007162 negative regulation of cell adhesion IDA 7556068
GO:0007165 signal transduction IDA 10572067
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway ISS 7514177
genes like me logo Genes that share ontologies with ERBB3: view

Compounds for ERBB3 Gene

(5) Tocris Compounds for ERBB3 Gene

Compound Action Cas Number
AG 1478 hydrochloride Highly potent EGFR-kinase inhibitor [170449-18-0]
AG 490 EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor [133550-30-8]
AG 825 Selective ErbB2 inhibitor [149092-50-2]
Iressa Orally active, selective EGFR inhibitor [184475-35-2]
PD 153035 hydrochloride EGFR-kinase inhibitor [183322-45-4]

(2) HMDB Compounds for ERBB3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure

(2) IUPHAR Ligand for ERBB3 Gene

Ligand Type Action Affinity Pubmed IDs
neuregulin-1 None None
neuregulin-2 None None

(47) Novoseek inferred chemical compound relationships for ERBB3 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 83.3 125
pertuzumab 81.7 13
hrgbeta1 81.6 2
gefitinib 81.5 39
trastuzumab 79.3 17
genes like me logo Genes that share compounds with ERBB3: view

Transcripts for ERBB3 Gene

Unigene Clusters for ERBB3 Gene

V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ERBB3

Clone Products

  • Addgene plasmids for ERBB3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERBB3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^ 17 ^
SP1: - - - -
SP2: - -
SP4: - - - - - - - - - - - - - -
SP8: -
SP10: -

ExUns: 18 ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29
SP1: - - -
SP2: - - - - - - -
SP3: - -
SP4: - - - - - - - - - - - - - - -
SP9: -

Relevant External Links for ERBB3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ERBB3 Gene

mRNA expression in normal human tissues for ERBB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ERBB3 Gene

This gene is overexpressed in Testis (26.0), Lung (22.4), Saliva (8.7), and Pancreas (8.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ERBB3 Gene

SOURCE GeneReport for Unigene cluster for ERBB3 Gene Hs.118681

mRNA Expression by UniProt/SwissProt for ERBB3 Gene

Tissue specificity: Epithelial tissues and brain
genes like me logo Genes that share expressions with ERBB3: view

Expression partners for ERBB3 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ERBB3 Gene

Orthologs for ERBB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ERBB3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ERBB3 35
  • 90.34 (n)
  • 92.81 (a)
ERBB3 36
  • 94 (a)
(Canis familiaris)
Mammalia ERBB3 35
  • 90.76 (n)
  • 93.8 (a)
ERBB3 36
  • 94 (a)
(Mus musculus)
Mammalia Erbb3 35
  • 86.97 (n)
  • 90.96 (a)
Erbb3 16
Erbb3 36
  • 91 (a)
(Pan troglodytes)
Mammalia ERBB3 35
  • 99.75 (n)
  • 99.85 (a)
(Rattus norvegicus)
Mammalia Erbb3 35
  • 87.3 (n)
  • 90.74 (a)
(Monodelphis domestica)
Mammalia ERBB3 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
-- 36
  • 85 (a)
(Gallus gallus)
Aves ERBB3 35
  • 68.6 (n)
  • 70.86 (a)
(Anolis carolinensis)
Reptilia ERBB3 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia erbb3 35
  • 62.24 (n)
  • 62.24 (a)
(Danio rerio)
Actinopterygii erbb3a 36
  • 50 (a)
erbb3b 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta Egfr 37
  • 39 (a)
(Caenorhabditis elegans)
Secernentea let-23 37
  • 28 (a)
Species with no ortholog for ERBB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ERBB3 Gene

Gene Tree for ERBB3 (if available)
Gene Tree for ERBB3 (if available)

Paralogs for ERBB3 Gene

Paralogs for ERBB3 Gene

genes like me logo Genes that share paralogs with ERBB3: view

Variants for ERBB3 Gene

Sequence variations from dbSNP and Humsavar for ERBB3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs705696 -- 56,086,864(-) ATGCT(C/T)GGCCT intron-variant
rs705708 -- 56,095,129(+) GTCTT(A/G)GGATC intron-variant
rs773116 -- 56,092,375(+) ataga(A/G)caaga intron-variant
rs773123 - 56,101,214(-) CCTGC(A/T)CCGGC reference, missense
rs798829 -- 56,091,485(+) CTCAC(A/G)CAACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERBB3 Gene

Variant ID Type Subtype PubMed ID
nsv832427 CNV Loss 17160897
esv275479 CNV Gain+Loss 21479260
esv1499550 CNV Insertion 17803354

Relevant External Links for ERBB3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

PCR Panel Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERBB3 Gene

Disorders for ERBB3 Gene

(1) OMIM Diseases for ERBB3 Gene (190151)


  • Lethal congenital contracture syndrome 2 (LCCS2) [MIM:607598]: A form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy, and congenital non-progressive joint contractures (arthrogryposis). The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. LCCS2 patients manifest craniofacial/ocular findings, lack of hydrops, multiple pterygia, and fractures, as well as a normal duration of pregnancy and a unique feature of a markedly distended urinary bladder (neurogenic bladder defect). The phenotype suggests a spinal cord neuropathic etiology. {ECO:0000269 PubMed:17701904}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for ERBB3 Gene

(67) Novoseek inferred disease relationships for ERBB3 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 72 94
breast carcinoma 64.8 26
tumors 61.5 136
cancer 58.8 73
viral leukemia 58.3 3

Relevant External Links for ERBB3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Tumor Gene Database (TGDB):
genes like me logo Genes that share disorders with ERBB3: view

No data available for Genatlas for ERBB3 Gene

Publications for ERBB3 Gene

  1. c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase. (PMID: 7685162) Katoh M. … Terada M. (Biochem. Biophys. Res. Commun. 1993) 3 4 23
  2. Neuroglycan C, a novel member of the neuregulin family. (PMID: 15358134) Kinugasa Y. … Higashiyama S. (Biochem. Biophys. Res. Commun. 2004) 3 4 23
  3. No association between the ERBB3 gene and schizophrenia in a Japanese population. (PMID: 17275115) Watanabe Y. … Someya T. (Neurosci. Res. 2007) 3 23 48
  4. Schizophrenia is not associated with the functional candidate gene ERBB3: results from a case-control study. (PMID: 16958035) Kanazawa T. … Tsuang M.T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 23 48
  5. ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation. (PMID: 20351256) Shi F. … Lemmon M.A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4 23

Products for ERBB3 Gene

  • Addgene plasmids for ERBB3

Sources for ERBB3 Gene

Back to Top