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Aliases for ERBB3 Gene

Aliases for ERBB3 Gene

  • Erb-B2 Receptor Tyrosine Kinase 3 2 3 5
  • V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3 2 3
  • Tyrosine Kinase-Type Cell Surface Receptor HER3 3 4
  • Human Epidermal Growth Factor Receptor 3 2 3
  • Proto-Oncogene-Like Protein C-ErbB-3 3 4
  • EC 4 63
  • HER3 3 4
  • Lethal Congenital Contracture Syndrome 2 2
  • P180-ErbB3 3
  • P45-SErbB3 3
  • P85-SErbB3 3
  • EC 2.7.10 63
  • MDA-BF-1 3
  • C-ErbB-3 3
  • C-ErbB3 3
  • ErbB3-S 3
  • ErbB-3 3
  • LCCS2 3

External Ids for ERBB3 Gene

Previous HGNC Symbols for ERBB3 Gene

  • LCCS2

Previous GeneCards Identifiers for ERBB3 Gene

  • GC12M056386
  • GC12M056841
  • GC12P056190
  • GC12P054760
  • GC12P056473
  • GC12P053512

Summaries for ERBB3 Gene

Entrez Gene Summary for ERBB3 Gene

  • This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for ERBB3 Gene

ERBB3 (Erb-B2 Receptor Tyrosine Kinase 3) is a Protein Coding gene. Diseases associated with ERBB3 include Lethal Congenital Contractural Syndrome 2 and Ovary Transitional Cell Carcinoma. Among its related pathways are Alzheimers Disease Pathway and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is TYK2.

UniProtKB/Swiss-Prot for ERBB3 Gene

  • Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5.

Tocris Summary for ERBB3 Gene

  • The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4). EGFR signaling drives many cellular responses.

Gene Wiki entry for ERBB3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERBB3 Gene

Genomics for ERBB3 Gene

Regulatory Elements for ERBB3 Gene

Enhancers for ERBB3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ERBB3 on UCSC Golden Path with GeneCards custom track

Promoters for ERBB3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ERBB3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ERBB3 Gene

56,079,857 bp from pter
56,103,507 bp from pter
23,651 bases
Plus strand

Genomic View for ERBB3 Gene

Genes around ERBB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERBB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERBB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERBB3 Gene

Proteins for ERBB3 Gene

  • Protein details for ERBB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor tyrosine-protein kinase erbB-3
    Protein Accession:
    Secondary Accessions:
    • A8K6L6
    • B4DIK7
    • B4DV32
    • E9PDT8
    • Q9BUD7

    Protein attributes for ERBB3 Gene

    1342 amino acids
    Molecular mass:
    148098 Da
    Quaternary structure:
    • Monomer and homodimer. Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5, GRB7, and MUC1. Interacts with MYOC (By similarity). Interacts with isoform 2 of PA2G4.

    Three dimensional structures from OCA and Proteopedia for ERBB3 Gene

    Alternative splice isoforms for ERBB3 Gene


neXtProt entry for ERBB3 Gene

Proteomics data for ERBB3 Gene at MOPED

Post-translational modifications for ERBB3 Gene

  • Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (By similarity). Subject to autophosphorylation.
  • Glycosylation at Asn 126, Asn 250, Asn 353, Asn 408, Asn 414, Asn 437, Asn 469, Asn 522, Asn 566, and Asn 616
  • Modification sites at PhosphoSitePlus

Domains & Families for ERBB3 Gene

Graphical View of Domain Structure for InterPro Entry



  • The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
  • The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
genes like me logo Genes that share domains with ERBB3: view

Function for ERBB3 Gene

Molecular function for ERBB3 Gene

GENATLAS Biochemistry:
avian erythroblastic leukemia,viral (v-erb-b) oncogene homolog 3,heregulin beta 1 receptor,signal transducer receptor,heterodimerizing with the ligand less recetpor ERBB2
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5.

Enzyme Numbers (IUBMB) for ERBB3 Gene

Gene Ontology (GO) - Molecular Function for ERBB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA,TAS --
GO:0004716 receptor signaling protein tyrosine kinase activity IEA --
GO:0004888 transmembrane signaling receptor activity ISS 7514177
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ERBB3: view
genes like me logo Genes that share phenotypes with ERBB3: view

Human Phenotype Ontology for ERBB3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ERBB3 Gene

MGI Knock Outs for ERBB3:

Animal Model Products

No data available for Transcription Factor Targets and HOMER Transcription for ERBB3 Gene

Localization for ERBB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERBB3 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

Jensen Localization Image for ERBB3 Gene COMPARTMENTS Subcellular localization image for ERBB3 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 3
nucleus 2
cytosol 1
endoplasmic reticulum 1
endosome 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ERBB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016323 basolateral plasma membrane IDA 12646923
GO:0043235 receptor complex ISS 7514177
genes like me logo Genes that share ontologies with ERBB3: view

Pathways & Interactions for ERBB3 Gene

SuperPathways for ERBB3 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 PI3K events in ERBB4 signaling
3 GPCR Pathway
4 Signaling by ERBB2
5 ERK Signaling
genes like me logo Genes that share pathways with ERBB3: view

SIGNOR curated interactions for ERBB3 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ERBB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS --
GO:0003197 endocardial cushion development IEA --
GO:0007162 negative regulation of cell adhesion IDA 7556068
GO:0007165 signal transduction IDA 10572067
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA,ISS 7514177
genes like me logo Genes that share ontologies with ERBB3: view

Drugs & Compounds for ERBB3 Gene

(54) Drugs for ERBB3 Gene - From: ClinicalTrials, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gefitinib Approved, Investigational Pharma Biomarker, inhibitor EGFR Inhibitors, Kinase Inhibitors, Epidermal growth factor receptor (EGFR) inhibitors 339
Adenosine triphosphate Approved Nutra 0
neuregulin-1 Pharma 0
neuregulin-2 Pharma 0
tyrosine Nutra 612

(22) Additional Compounds for ERBB3 Gene - From: HMDB, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
AG 18
AG 490
AG 99
Methyl 2,5-dihydroxycinnamate

(5) Tocris Compounds for ERBB3 Gene

Compound Action Cas Number
AG 18 EGFR/PDGFR-kinase inhibitor 118409-57-7
AG 490 EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor 133550-30-8
AG 99 EGFR-kinase inhibitor 122520-85-8
Methyl 2,5-dihydroxycinnamate EGFR-kinase inhibitor 63177-57-1
Tyrphostin B44, (-) enantiomer EGFR-kinase inhibitor 133550-32-0
genes like me logo Genes that share compounds with ERBB3: view

Transcripts for ERBB3 Gene

Unigene Clusters for ERBB3 Gene

V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERBB3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^ 17 ^
SP1: - - - -
SP2: - -
SP4: - - - - - - - - - - - - - -
SP8: -
SP10: -

ExUns: 18 ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29
SP1: - - -
SP2: - - - - - - -
SP3: - -
SP4: - - - - - - - - - - - - - - -
SP9: -

Relevant External Links for ERBB3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ERBB3 Gene

mRNA expression in normal human tissues for ERBB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ERBB3 Gene

This gene is overexpressed in Testis (26.0), Lung (22.4), Saliva (8.7), and Pancreas (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ERBB3 Gene

SOURCE GeneReport for Unigene cluster for ERBB3 Gene Hs.118681

mRNA Expression by UniProt/SwissProt for ERBB3 Gene

Tissue specificity: Epithelial tissues and brain.
genes like me logo Genes that share expression patterns with ERBB3: view

Protein tissue co-expression partners for ERBB3 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for ERBB3 Gene

Orthologs for ERBB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ERBB3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ERBB3 35
  • 90.34 (n)
  • 92.81 (a)
ERBB3 36
  • 94 (a)
(Canis familiaris)
Mammalia ERBB3 35
  • 90.76 (n)
  • 93.8 (a)
ERBB3 36
  • 94 (a)
(Mus musculus)
Mammalia Erbb3 35
  • 86.97 (n)
  • 90.96 (a)
Erbb3 16
Erbb3 36
  • 91 (a)
(Pan troglodytes)
Mammalia ERBB3 35
  • 99.75 (n)
  • 99.85 (a)
(Rattus norvegicus)
Mammalia Erbb3 35
  • 87.3 (n)
  • 90.74 (a)
(Monodelphis domestica)
Mammalia ERBB3 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
-- 36
  • 85 (a)
(Gallus gallus)
Aves ERBB3 35
  • 68.6 (n)
  • 70.86 (a)
(Anolis carolinensis)
Reptilia ERBB3 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia erbb3 35
  • 62.24 (n)
  • 62.24 (a)
(Danio rerio)
Actinopterygii erbb3a 36
  • 50 (a)
erbb3b 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta Egfr 37
  • 39 (a)
(Caenorhabditis elegans)
Secernentea let-23 37
  • 28 (a)
Species with no ortholog for ERBB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ERBB3 Gene

Gene Tree for ERBB3 (if available)
Gene Tree for ERBB3 (if available)

Paralogs for ERBB3 Gene

Paralogs for ERBB3 Gene

genes like me logo Genes that share paralogs with ERBB3: view

Variants for ERBB3 Gene

Sequence variations from dbSNP and Humsavar for ERBB3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs34379766 - 56,080,359(+) GGGCT(A/C/T)CGAGG reference, missense
rs56017157 - 56,083,757(+) GTGTC(C/T)TGGGA reference, missense
VAR_042103 An ovarian mucinous carcinoma sample
rs56107455 - 56,087,640(+) CCAGA(C/T)ATGTG reference, missense
rs56387488 - 56,095,798(+) TGGAA(C/T)GGGGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ERBB3 Gene

Variant ID Type Subtype PubMed ID
nsv832427 CNV Loss 17160897
esv275479 CNV Gain+Loss 21479260
esv1499550 CNV Insertion 17803354

Variation tolerance for ERBB3 Gene

Residual Variation Intolerance Score: 13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.28; 70.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ERBB3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERBB3 Gene

Disorders for ERBB3 Gene

MalaCards: The human disease database

(22) MalaCards diseases for ERBB3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lethal congenital contractural syndrome 2
  • lethal congenital contracture syndrome 2
ovary transitional cell carcinoma
  • malignant ovarian transitional cell neoplasm
lethal congenital contracture syndrome
  • lethal congenital contracture syndrome 1
gestational trophoblastic tumor
  • gestational trophoblastic neoplasm
clear cell sarcoma
  • adult soft part clear cell sarcoma
- elite association - COSMIC cancer census association via MalaCards
Search ERBB3 in MalaCards View complete list of genes associated with diseases


  • Lethal congenital contracture syndrome 2 (LCCS2) [MIM:607598]: A form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy, and congenital non-progressive joint contractures (arthrogryposis). The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. LCCS2 patients manifest craniofacial/ocular findings, lack of hydrops, multiple pterygia, and fractures, as well as a normal duration of pregnancy and a unique feature of a markedly distended urinary bladder (neurogenic bladder defect). The phenotype suggests a spinal cord neuropathic etiology. {ECO:0000269 PubMed:17701904}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ERBB3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Tumor Gene Database (TGDB):
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ERBB3: view

No data available for Genatlas for ERBB3 Gene

Publications for ERBB3 Gene

  1. c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase. (PMID: 7685162) Katoh M. … Terada M. (Biochem. Biophys. Res. Commun. 1993) 3 4 23 67
  2. The upgraded role of HER3 and HER4 receptors in breast cancer. (PMID: 19481955) Koutras A.K. … Kalofonos H.P. (Crit. Rev. Oncol. Hematol. 2010) 3 23
  3. P2Y2 nucleotide receptors mediate metalloprotease-dependent phosphorylation of epidermal growth factor receptor and ErbB3 in human salivary gland cells. (PMID: 20064929) Ratchford A.M. … Weisman G.A. (J. Biol. Chem. 2010) 3 23
  4. Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin. (PMID: 20103628) Huang X. … Liu B. (Cancer Res. 2010) 3 23
  5. Expression of the HER-1-4 family of receptor tyrosine kinases in neuroendocrine tumours. (PMID: 20204273) Srirajaskanthan R. … Caplin M.E. (Oncol. Rep. 2010) 3 23

Products for ERBB3 Gene

Sources for ERBB3 Gene