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ERBB3 Gene

protein-coding   GIFtS: 76
GCID: GC12P056473

V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog...

(Previous name: lethal congenital contracture syndrome 2)
(Previous symbol: LCCS2)
  See ERBB3-related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 31 2     c-erbB-32
LCCS21 2 5     c-erbB32
Proto-Oncogene-Like Protein C-ErbB-32 3     erbB3-S2
Tyrosine Kinase-Type Cell Surface Receptor HER32 3     p180-ErbB32
HER32 3     p45-sErbB32
EC 8     p85-sErbB32
Lethal Congenital Contracture Syndrome 21     Receptor Tyrosine-Protein Kinase ErbB-32
ErbB-32     EC 2.7.108

External Ids:    HGNC: 34311   Entrez Gene: 20652   Ensembl: ENSG000000653617   OMIM: 1901515   UniProtKB: P218603   

Export aliases for ERBB3 gene to outside databases

Previous GC identifiers: GC12M056386 GC12M056841 GC12P056190 GC12P054760 GC12P053512

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ERBB3 Gene:
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases.
This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can
bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form
heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to
the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or
overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast
tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One
isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity
of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly
characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for ERBB3 Gene:
ERBB3 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3) is a protein-coding gene. Diseases associated with ERBB3 include lethal congenital contracture syndrome 2, and lethal congenital contractural syndrome 2. GO annotations related to this gene include protein heterodimerization activity and protein homodimerization activity. An important paralog of this gene is SYK.

UniProtKB/Swiss-Prot: ERBB3_HUMAN, P21860
Function: Binds and is activated by neuregulins and NTAK

summary for ERBB3 Gene:
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members
of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4).
EGFR signaling is initiated by ligand binding to the extracellular ligand binding domain. This initiates
receptor homo-/hetero-dimerization and autophosphorylation by the intracellular kinase domain, resulting in
receptor activation. Following activation, phosphorylation of cytoplasmic substrates occurs and a signaling
cascade is initiated that drives many cellular responses, including changes in gene expression, cytoskeletal
rearrangement, anti-apoptosis and increased cell proliferation.

Gene Wiki entry for ERBB3 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ERBB3 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ERBB3 promoter sequence
   Search Chromatin IP Primers for ERBB3

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ERBB3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13

ERBB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ERBB3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P056473:  view genomic region     (about GC identifiers)

56,473,641 bp from pter      End:
56,497,291 bp from pter
23,651 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section

UniProtKB/Swiss-Prot: ERBB3_HUMAN, P21860 (See protein sequence)
Recommended Name: Receptor tyrosine-protein kinase erbB-3 precursor  
Size: 1342 amino acids; 148098 Da
Subunit: Monomer and homodimer. Heterodimer with each of the other ERBB receptors (Potential). Interacts with
CSPG5, PA2G4, GRB7 and MUC1
Developmental stage: Overexpressed in a subset of human mammary tumors
6 PDB 3D structures from and Proteopedia for ERBB3:
1M6B (3D)        2L9U (3D)        3KEX (3D)        3LMG (3D)        3P11 (3D)        4LEO (3D)    
Secondary accessions: A8K6L6 B4DIK7 B4DV32 E9PDT8 Q9BUD7
Alternative splicing: 5 isoforms:  P21860-1   P21860-2   P21860-3   P21860-4   P21860-5   

Explore the universe of human proteins at neXtProt for ERBB3: NX_P21860

Explore proteomics data for ERBB3 at MOPED

Post-translational modifications: 

  • Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of
    phosphatidylinositol 3-kinase (By similarity). Subject to autophosphorylation1
  • Glycosylation2 at Asn126, Asn250, Asn353, Asn408, Asn414, Asn437, Asn469, Asn522, Asn566, Asn616
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ERBB3 (P21860) (see all 22)

    See ERBB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001005915.1  NP_001973.2  

    ENSEMBL proteins: 
     ENSP00000448636   ENSP00000449138   ENSP00000267101   ENSP00000415753   ENSP00000448671  
     ENSP00000448483   ENSP00000447510   ENSP00000449713   ENSP00000408340   ENSP00000448946  
     ENSP00000449129   ENSP00000448729   ENSP00000399178  
    Reactome Protein details: P21860

    ERBB3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ERBB3 (ErbB3/Her3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for ERBB3
    OriGene Protein Over-expression Lysate for ERBB3
    OriGene MassSpec for ERBB3
    OriGene Custom Protein Services for ERBB3
    GenScript Purified and Recombinant Proteins for ERBB3
    Novus Biologicals ERBB3 Proteins
    Novus Biologicals ERBB3 Lysates
    Sino Biological Recombinant Protein for ERBB3
    Sino Biological Cell Lysate for ERBB3
    ProSpec Recombinant Protein for ERBB3
    Browse Proteins at Cloud-Clone Corp.

    Search eBioscience for Proteins for ERBB3 

    antibodies-online proteins for ERBB3 (15 products) 

    antibodies-online peptides for ERBB3

    Search GeneTex for Proteins for ERBB3 

    ERBB3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ERBB3
    R&D Systems Antibodies for ERBB3 (ErbB3/Her3)
    Cell Signaling Technology (CST) Antibodies for ERBB3  (HER3)
    OriGene Antibodies for ERBB3
    OriGene Custom Antibody Services for ERBB3
    Novus Biologicals ERBB3 Antibodies
    Abcam antibodies for ERBB3
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for ERBB3
    antibodies-online antibodies for ERBB3 (348 products) 

    GeneTex Antibodies for ERBB3:  
                        ERBB3 Antibodies

    ERBB3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ERBB3
    R&D Systems ELISAs for ERBB3 (ErbB3/Her3)         (see all)
    GenScript Custom Assay Services for ERBB3
    Cell Signaling Technology (CST) Sandwich ELISA Kits for ERBB3 (HER3)
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ERBB3 
    antibodies-online kits for ERBB3 (15 products) 

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    IUPHAR Guide to PHARMACOLOGY protein family classification: v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
    ErbB (epidermal growth factor) receptor family

    Selected InterPro protein domains (see all 9):
     IPR006212 Furin_repeat
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR000494 EGF_rcpt_L
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P21860

    ProtoNet protein and cluster: P21860

    4 Blocks protein domains:
    IPB000494 Epidermal growth-factor receptor (EGFR)
    IPB006211 Furin-like cysteine rich region
    IPB006212 Furin-like repeat
    IPB008266 Tyrosine protein kinase

    UniProtKB/Swiss-Prot: ERBB3_HUMAN, P21860
    Domain: The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily
    Similarity: Contains 1 protein kinase domain

    Find genes that share domains with ERBB3           About GenesLikeMe

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ERBB3_HUMAN, P21860
    Function: Binds and is activated by neuregulins and NTAK
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for ERBB3:
    avian erythroblastic leukemia,viral (v-erb-b) oncogene homolog 3,heregulin beta 1 receptor,signal transducer
    receptor,heterodimerizing with the ligand less recetpor ERBB2

         Enzyme Numbers (IUBMB): EC 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713NOT protein tyrosine kinase activity IDA7556068
    GO:0004714transmembrane receptor protein tyrosine kinase activity ----
    GO:0004716receptor signaling protein tyrosine kinase activity ----
    GO:0004888transmembrane signaling receptor activity ISS7514177
    Find genes that share ontologies with ERBB3           About GenesLikeMe

         4 GenomeRNAi human phenotypes for ERBB3:
     Decreased substrate adherent c  Decreased viability  Increased cell death HMECs cel  Synthetic lethal with c-Myc af 

         Selected MGI mutant phenotypes (inferred from 11 alleles(MGI details for Erbb3) (see all 17):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  immune system  integument 
     mortality/aging  muscle  nervous system  normal  pigmentation 

    Find genes that share phenotypes with ERBB3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ERBB3: Erbb3tm1.1Dwt Erbb3tm1Gne Erbb3tm1Cbm Erbb3tm2Cbm

       genOway: Develop your customized and physiologically relevant rodent model for ERBB3

        Taconic Biosicences: Generate A Custom CRISPR Mouse Model For Your Study 

    CRISPR Knockouts: 
       OriGene CRISPR knockouts for ERBB3

    miRTarBase miRNAs that target ERBB3:
    hsa-mir-24-3p (MIRT030589), hsa-mir-125a-5p (MIRT005117), hsa-mir-125b-5p (MIRT002938), hsa-mir-22-3p (MIRT006210), hsa-mir-205-5p (MIRT003659)

    Block miRNA regulation of human, mouse, rat ERBB3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ERBB3 (see all 57):
    hsa-miR-106a hsa-miR-301a hsa-miR-500a hsa-miR-766 hsa-miR-519a hsa-miR-877* hsa-miR-93 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidERBB3 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for ERBB3
    Predesigned siRNA for gene silencing in human, mouse, rat ERBB3

    OriGene clones in human, mouse for ERBB3 (see all 15)
    OriGene ORF clones in mouse, rat for ERBB3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ERBB3 (NM_001005915)
    Sino Biological Human cDNA Clone for ERBB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERBB3
    Addgene plasmids for ERBB3 

    Cell Line
    GenScript Custom overexpressing Cell Line Services for ERBB3
    Browse ESI BIO Cell Lines and PureStem Progenitors for ERBB3 
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERBB3

    Flow Cytometry

    eBioscience FlowRNA Probe Sets ( VA1-11716) for ERBB3 

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Subcellular locations from UniProtKB/Swiss-Prot
    ERBB3_HUMAN, P21860: Isoform 1: Cell membrane; Single-pass type I membrane protein
    ERBB3_HUMAN, P21860: Isoform 2: Secreted
    Subcellular locations from COMPARTMENTS: 

    plasma membrane5
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA11389077
    GO:0005886plasma membrane TAS17701904
    GO:0005887integral component of plasma membrane TAS2687875
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with ERBB3           About GenesLikeMe

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    SuperPaths for ERBB3 About   (see all 39)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52
    2Development ERBB-family signaling
    Development ERBB-family signaling0.52
    ErbB receptor signaling network0.00
    GRB7 events in ERBB2 signaling0.00
    3Signaling by FGFR
    Signaling by FGFR0.91
    Signaling by PDGF0.87
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.83
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR in Cancer0.82
    Downstream signal transduction0.90
    NGF signalling via TRKA from the plasma membrane0.71
    4PI-3K cascade
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    GAB1 signalosome0.93
    PI3K events in ERBB2 signaling0.88
    PI-3K cascade0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Signaling by SCF-KIT0.72
    5GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38

    Find genes that share SuperPaths with ERBB3           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for ERBB3
        Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ERBB3 (see all 35)
        Paxillin Interactions
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    JNK Pathway
    Tec Kinases Signaling

    1 Cell Signaling Technology (CST) Pathway for ERBB3
        Tyrosine Kinases / Adaptors

    4 Tocris Bioscience Pathways for ERBB3
        Akt Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    MAPK Pathway

    3 GeneGo (Thomson Reuters) Pathways for ERBB3
        Development ERBB-family signaling
    Development Ligand-independent activation of ESR1 and ESR2
    Apoptosis and survival Role of CDK5 in neuronal death and survival

    Selected BioSystems Pathways for ERBB3 (see all 7)
        Heart Development
    ErbB signaling pathway
    Signaling Pathways in Glioblastoma
    IL-6 Signaling Pathway
    a6b1 and a6b4 Integrin signaling

    1 Sino Biological Pathway for ERBB3
        EGFR Signaling Pathway

    Selected Reactome Pathways for ERBB3 (see all 8)
        Downregulation of ERBB2:ERBB3 signaling
    GRB7 events in ERBB2 signaling
    PI3K events in ERBB2 signaling
    SHC1 events in ERBB2 signaling
    Signaling by ERBB2

    1 PharmGKB Pathway for ERBB3
        EGFR Inhibitor Pathway, Pharmacodynamics

    5 Kegg Pathways  (Kegg details for ERBB3):
        ErbB signaling pathway
    Calcium signaling pathway
    Proteoglycans in cancer
    MicroRNAs in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ERBB3 (see all 6): 
              Lung Cancer in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              Cancer Drug Targets in human mouse rat
              Multiple Sclerosis in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat


        GeneGlobe Interaction Network for ERBB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ERBB3 (P218601, 2, 3 ENSP000002671014) via UniProtKB, MINT, STRING, and/or I2D (see all 205)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R2O004591, 2, 3, ENSP000002222544EBI-720706,EBI-346930 MINT-74627 MINT-74618 MINT-61512 MINT-74629 MINT-74637 MINT-61520 MINT-74625 MINT-74638 MINT-61513 MINT-74624 MINT-74636 MINT-74633 MINT-74628 MINT-61519 MINT-74626 MINT-74639 MINT-61516 MINT-74635 MINT-74634 MINT-61517 I2D: score=5 STRING: ENSP00000222254
    ABL2P426841, 2, 3, ENSP000003565954EBI-720706,EBI-1102694 MINT-74450 MINT-74445 MINT-74452 MINT-74446 MINT-74447 MINT-74451 MINT-74448 MINT-74453 MINT-74449 MINT-74454 I2D: score=2 STRING: ENSP00000356595
    PIK3R3Q925691, 2, 3, ENSP000002627414EBI-720706,EBI-79893 MINT-74643 MINT-74669 MINT-74652 MINT-74647 MINT-74651 MINT-74656 MINT-74653 MINT-74672 MINT-74644 MINT-74668 MINT-74646 MINT-74645 MINT-74667 MINT-74654 MINT-74666 MINT-74665 MINT-74657 MINT-74655 MINT-74670 MINT-74671 I2D: score=2 STRING: ENSP00000262741
    PIK3R1P279861, 2, 3, ENSP000002743354EBI-720706,EBI-79464 MINT-74605 MINT-74614 MINT-74600 MINT-74611 MINT-74604 MINT-74616 MINT-74613 MINT-74601 MINT-74612 MINT-74617 MINT-74615 MINT-74597 MINT-74602 MINT-74596 MINT-74603 I2D: score=7 STRING: ENSP00000274335
    GRB7Q144511, 2, 3, ENSP000003107714EBI-720706,EBI-970191 MINT-74546 MINT-74548 MINT-74545 MINT-74547 MINT-8027964 MINT-8034751 I2D: score=5 STRING: ENSP00000310771
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003197endocardial cushion development IEA--
    GO:0006468protein phosphorylation ----
    GO:0007162negative regulation of cell adhesion IDA7556068
    GO:0007165signal transduction IDA10572067
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway ISS7514177

    Find genes that share ontologies with ERBB3           About GenesLikeMe

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ERBB3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Iressa Orally active, selective EGFR inhibitor [184475-35-2]
    AG 490 EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor [133550-30-8]
    JNJ 28871063 hydrochloridePotent ErbB receptor family inhibitor[944341-54-2]
    AG 1478 hydrochlorideHighly potent EGFR-kinase inhibitor[153436-53-4]
    GenisteinEGFR kinase inhibitor. Also estrogen and PPARgamma ligand[446-72-0]

    2 HMDB Compounds for ERBB3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 IUPHAR Ligands for ERBB3 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian))    About this table
    LigandTypeActionAffinityPubmed IDs

    Selected Novoseek inferred chemical compound relationships for ERBB3 gene (see all 47)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 83.3 232 7514177 (4), 7929151 (4), 8058768 (4), 11189010 (3) (see all 99)
    pertuzumab 81.7 15 19737968 (6), 17627612 (3), 18632642 (2), 17547474 (1) (see all 5)
    hrgbeta1 81.6 3 12209601 (2)
    gefitinib 81.5 55 15731348 (7), 18803287 (5), 17638894 (4), 16818711 (3) (see all 20)
    trastuzumab 79.3 18 20103628 (5), 18625725 (2), 19276389 (1), 19934333 (1) (see all 12)
    lapatinib 77.3 6 16020981 (1), 18334972 (1), 14737100 (1), 15755991 (1)
    erlotinib 69.3 17 16928826 (7), 17457047 (5)
    cetuximab 69.1 8 19276677 (2), 18297114 (2), 15585383 (1), 16424038 (1) (see all 6)
    phosphatidylinositol 64.8 45 7929151 (5), 7535767 (4), 9886492 (2), 8732665 (2) (see all 22)
    ag 1478 57.2 3 18682844 (1), 10533979 (1)

    Find genes that share compounds with ERBB3           About GenesLikeMe

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    REFSEQ mRNAs for ERBB3 gene (2 alternative transcripts): 
    NM_001005915.1  NM_001982.3  

    Unigene Cluster for ERBB3:

    V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
    Hs.118681  [show with all ESTs]
    Unigene Representative Sequence: NM_001982
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000549282 ENST00000549061 ENST00000267101(uc001sjh.3 uc009zoj.3 uc010sqb.2 uc010sqc.2 uc009zok.3 uc001sjk.3)
    ENST00000411731(uc001sjg.3) ENST00000550869 ENST00000551085 ENST00000546884
    ENST00000551242 ENST00000549672 ENST00000415288(uc001sjj.1) ENST00000549472
    ENST00000546748 ENST00000551176(uc001sji.3) ENST00000549205 ENST00000550828
    ENST00000550070 ENST00000549644 ENST00000553131
    Block miRNA regulation of human, mouse, rat ERBB3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ERBB3 (see all 57):
    hsa-miR-106a hsa-miR-301a hsa-miR-500a hsa-miR-766 hsa-miR-519a hsa-miR-877* hsa-miR-93 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidERBB3 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for ERBB3
    Predesigned siRNA for gene silencing in human, mouse, rat ERBB3
    OriGene clones in human, mouse for ERBB3 (see all 15)
    OriGene ORF clones in mouse, rat for ERBB3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ERBB3 (NM_001005915)
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERBB3
    Addgene plasmids for ERBB3 
    OriGene qPCR primer pairs and template standards for ERBB3
    OriGene qSTAR qPCR primer pairs in human, mouse for ERBB3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ERBB3
      QuantiTect SYBR Green Assays in human, mouse, rat ERBB3
      QuantiFast Probe-based Assays in human, mouse, rat ERBB3
    Flow Cytometry

    eBioscience FlowRNA Probe Sets ( VA1-11716) for ERBB3 

    Additional mRNA sequence: 

    AF086028.1 AK124710.1 AK125028.1 AK291681.1 AK294719.1 AK295650.1 AK300909.1 BC002706.2 
    BC041579.1 BC082992.1 BT007226.1 M29366.1 M34309.1 S61953.1 U88357.1 U88358.1 
    U88359.1 U88360.1 

    20 DOTS entries:

    DT.98131702  DT.95179527  DT.95102464  DT.100791868  DT.101982408  DT.100700960  DT.213585  DT.100038754 
    DT.91963462  DT.75114482  DT.95184370  DT.86837952  DT.92440238  DT.101982406  DT.121128974  DT.121129014 
    DT.95082546  DT.121634328  DT.444493  DT.91823725 

    Selected AceView cDNA sequences (see all 234):

    AF086028 BU753343 BQ721795 BU193917 AI611284 AI201918 NM_001982 CR621450 
    AI342554 BQ023875 AI873699 BQ218231 BX479156 BQ877641 BC002706 BQ028543 
    W92344 AW375856 BF035030 BP357593 BQ439773 AW796518 BE304403 CB160706 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ERBB3 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^ 17 ^
    SP1:                          -                 -                                                                                         -           -         
    SP2:                                                                                                                                      -           -         
    SP4:                          -                 -                                         -     -     -     -     -     -     -     -     -     -     -     -   

    ExUns: 18 ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29
    SP1:        -                             -           -                                                         
    SP2:        -           -     -     -     -     -     -                                                         
    SP3:                                      -           -                                                         
    SP4:  -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                     

    ECgene alternative splicing isoforms for ERBB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ERBB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    ERBB3 Expression
    About this image

    ERBB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     Heart (Cardiovascular System)    fully expand to see all 6 entries
             Atrioventricular Valve Cells Atrioventricular Valves
             Cardiac progenitor cells (Sca1+)
     Peripheral Nervous System (Nervous System)    fully expand to see all 4 entries
             Immature Schwann Cells Peripheral Nerve Domain
     Kidney (Urinary System)    fully expand to see all 3 entries
             Ureteric Bud Cells Ureteric Bud
             Ureteric Bud
     Brain (Nervous System)    fully expand to see all 2 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
    ERBB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ERBB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.118681

    UniProtKB/Swiss-Prot: ERBB3_HUMAN, P21860
    Tissue specificity: Epithelial tissues and brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ERBB3 (see all 6): 
              Lung Cancer in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              Cancer Drug Targets in human mouse rat
              Multiple Sclerosis in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    OriGene qPCR primer pairs and template standards for ERBB3
    OriGene qSTAR qPCR primer pairs in human, mouse for ERBB3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ERBB3
    QuantiTect SYBR Green Assays in human, mouse, rat ERBB3
    QuantiFast Probe-based Assays in human, mouse, rat ERBB3
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERBB3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ERBB3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Erbb31 , 5 v-erb-b2 erythroblastic leukemia viral oncogene homolog more1, 5 86.97(n)1
      10 (77.10 cM)5
    138671  NM_010153.11  NP_034283.11 
    (Gallus gallus)
    Aves ERBB31 v-erb-b2 erythroblastic leukemia viral oncogene homolog more 68.6(n)
      693245  NM_001044669.1  NP_001038134.1 
    (Anolis carolinensis)
    Reptilia ERBB36
    v-erb-b2 avian erythroblastic leukemia viral oncog...
    1 ↔ 1
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia erbb31 v-erb-b2 erythroblastic leukemia viral oncogene homolog more 62.24(n)
      100493384  XM_002934516.2  XP_002934562.2 
    (Danio rerio)
    Actinopterygii erbb3a6
    v-erb-b2 erythroblastic leukemia viral oncogene ho...
    v-erb-b2 erythroblastic leukemia viral oncogene ho...
    1 ↔ many
    1 ↔ many
    6(7383038-7448242) ENSDARG00000006202
    23(25519750-25575005) ENSDARG00000036993

    ENSEMBL Gene Tree for ERBB3 (if available)
    TreeFam Gene Tree for ERBB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for ERBB3 gene
    SYK2  TNK12  JAK32  JAK22  TNK22  TYK22  ERBB42  JAK12  
    PTK22  ERBB22  ZAP702  EGFR2  PTK2B2  
    16 SIMAP similar genes for ERBB3 using alignment to 9 protein entries:     ERBB3_HUMAN (see all proteins):
    c-erbB-3    EPHA4    ERBB4    FGFR1    EGFR    ERBB2
    HER-2    ABL1    EPHA2    tec    FGR    INSR
    RYK    DKFZp686M05208    MAP3K11    TXK

    Find genes that share paralogs with ERBB3           About GenesLikeMe

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    Selected SNPs for ERBB3 (see all 735)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 12 posSequence#AA
    An ovarian mucinous carcinoma sample4--see VAR_0421032 V M mis40--------
    Cuntested156493973(+) TTTTAA/C/GGTCCA 2 S G mis10--------
    --56472042(+) GCCCAG/TCTAAT 2 -- us2k10--------
    --56472052(+) TTTTTA/GTATTT 2 -- us2k10--------
    --56472100(+) GTCTCA/GAACTC 2 -- us2k10--------
    --56472126(+) CTGCCC/TGCCTC 2 -- us2k10--------
    C--56472279(+) GTCTC-/AAAAAA 2 -- us2k10--------
    --56472286(+) AAAAAA/CAAAAA 2 -- us2k10--------
    C--56472293(+) AAAAA-/A/GGAAAA 2 -- us2k11NA 2
    --56472294(+) AAAAAA/GAAAAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ERBB3 (56473641 - 56497291 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ERBB3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1499550CNV Insertion17803354
    nsv832427CNV Loss17160897
    esv275479CNV Gain+Loss21479260

    Human Gene Mutation Database (HGMD): ERBB3
    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing ERBB3:
    Oncogenes & Tumor Suppressor Genes 384HC
    Gastric Cancer
    SeqTarget long-range PCR primers for resequencing ERBB3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 190151   
    OMIM disorders: 607598  
    UniProtKB/Swiss-Prot: ERBB3_HUMAN, P21860
  • Lethal congenital contracture syndrome 2 (LCCS2) [MIM:607598]: A form of lethal congenital contracture
    syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme
    skeletal muscle atrophy, and congenital non-progressive joint contractures (arthrogryposis). The contractures can
    involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension
    limitations evident at birth. LCCS2 patients manifest craniofacial/ocular findings, lack of hydrops, multiple
    pterygia, and fractures, as well as a normal duration of pregnancy and a unique feature of a markedly distended
    urinary bladder (neurogenic bladder defect). The phenotype suggests a spinal cord neuropathic etiology. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 13 diseases for ERBB3:    
    About MalaCards
    lethal congenital contracture syndrome 2    lethal congenital contractural syndrome 2    gestational trophoblastic tumor    medulloblastoma
    carotid body tumor    congenital contractures    verrucous carcinoma    breast cancer
    charcot-marie-tooth disease type 1a    pancreatic cancer    charcot-marie-tooth disease type 1    childhood medulloblastoma
    prostate cancer

    3 inferred disease relationships from the University of Copenhagen DISEASES database for ERBB3:
    Breast cancer     Carcinoma     Lung cancer

    Find genes that share disorders with ERBB3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ERBB3 gene (see all 67)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 72 111 17266042 (4), 18425425 (4), 18632642 (4), 15704104 (3) (see all 61)
    breast carcinoma 64.8 30 15770691 (3), 9823984 (2), 8732665 (2), 10473632 (2) (see all 21)
    tumors 61.5 169 18507044 (5), 18398842 (4), 19401448 (4), 11789762 (3) (see all 99)
    cancer 58.8 98 20215504 (5), 20179223 (4), 18404164 (3), 9712416 (3) (see all 57)
    viral leukemia 58.3 3 15150091 (1), 17275115 (1), 12021921 (1)
    nsclc 56.6 37 15731348 (6), 16843264 (3), 19648825 (2), 16288303 (2) (see all 19)
    carcinoma 47.2 55 9494565 (4), 7673253 (3), 11135221 (3), 8683379 (3) (see all 29)
    carcinoma non-small cell lung 43.6 3 9127320 (3)
    cancer lung 41.9 19 17631905 (3), 14739033 (2), 17627612 (2), 20351256 (1) (see all 13)
    metastasis 41.1 43 18398842 (5), 18172732 (3), 18698037 (3), 12888923 (2) (see all 24)

    Genetic Association Database (GAD): ERBB3
    Human Genome Epidemiology (HuGE) Navigator: ERBB3 (31 documents)
    Tumor Gene Database (TGDB): ERBB3

    Export disorders for ERBB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ERBB3 gene, integrated from 10 sources (see all 761) (see top 10):
    (articles sorted by number of sources associating them with ERBB3)

    1. c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase. (PubMed id 7685162)1, 2, 9 Katoh M.... Terada M. (Biochem. Biophys. Res. Commun. 1993)
    2. Schizophrenia is not associated with the functional candidate gene ERBB3: results from a case-control study. (PubMed id 16958035)1, 4, 9 Kanazawa T....Tsuang M.T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    3. No association between the ERBB3 gene and schizophrenia in a Japanese population. (PubMed id 17275115)1, 4, 9 Watanabe Y....Someya T. (Neurosci. Res. 2007)
    4. ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation. (PubMed id 20351256)1, 2, 9 Shi F.... Lemmon M.A. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    5. Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3. (PubMed id 9516479)1, 2, 9 Fiddes R.J.... Daly R.J. (J. Biol. Chem. 1998)
    6. Neuroglycan C, a novel member of the neuregulin family. (PubMed id 15358134)1, 2, 9 Kinugasa Y....Higashiyama S. (Biochem. Biophys. Res. Commun. 2004)
    7. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. (PubMed id 21829393)1, 4 Plagnol V....Todd J.A. (PLoS Genet. 2011)
    8. A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. (PubMed id 20962850)1, 4 Budarf M.L....Rioux J.D. (Genes Immun. 2011)
    9. Somatic mutations in epidermal growth factor receptor signaling pathway genes in non-small cell lung cancers. (PubMed id 20881644)1, 4 Lee S.Y....Park J.Y. (J Thorac Oncol 2010)
    10. Genome-wide searching of rare genetic variants in WTCCC data. (PubMed id 20549515)1, 4 Feng T. and Zhu X. (Hum. Genet. 2010)
    11. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    12. A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk. (PubMed id 20446891)1, 4 Andersson U....Melin B. (Acta Oncol 2010)
    13. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    14. Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis. (PubMed id 20647273)1, 4 Hinks A....Thomson W. (Ann. Rheum. Dis. 2010)
    15. [Association of the polymorphisms of the ERBB3 and SH2B3 genes with type 1 diabetes]. (PubMed id 20586186)1, 4 Nikitin A.G....Nosikov V.V. (Mol. Biol. (Mosk.) 2010)
    16. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    17. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    18. Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk. (PubMed id 20203524)1, 4 Pierce B.L. and Ahsan H. (Hum. Hered. 2010)
    19. Association of type 1 diabetes with two Loci on 12q13 and 16p13 and the influence coexisting thyroid autoimmunity in Japanese. (PubMed id 18940880)1, 4 Awata T....Katayama S. (J. Clin. Endocrinol. Metab. 2009)
    20. Case-control study of association between the functional candidate gene ERBB3 and schizophrenia in Caucasian population. (PubMed id 19995212)1, 4 Li D....He L. (World J. Biol. Psychiatry 2009)
    21. Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis. (PubMed id 19951419)1, 4 Carr E.J....Smith K.G. (BMC Med. Genet. 2009)
    22. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. (PubMed id 19430480)1, 4 Barrett J.C....Rich S.S. (Nat. Genet. 2009)
    23. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    24. A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. (PubMed id 18198356)1, 4 Hakonarson H....Polychronakos C. (Diabetes 2008)
    25. Shared and distinct genetic variants in type 1 diabetes and celiac disease. (PubMed id 19073967)1, 4 Smyth D.J....Todd J.A. (N. Engl. J. Med. 2008)
    26. Polymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency. (PubMed id 18593762)1, 4 Skinningsrud B....Undlien D.E. (J. Clin. Endocrinol. Metab. 2008)
    27. Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. (PubMed id 18978792)1, 4 Cooper J.D....Todd J.A. (Nat. Genet. 2008)
    28. Lethal congenital contractural syndrome type 2 (LCCS2) is caused by a mutation in ERBB3 (Her3), a modulator of the phosphatidylinositol-3- kinase/Akt pathway. (PubMed id 17701904)1, 2 Narkis G.... Birk O.S. (Am. J. Hum. Genet. 2007)
    29. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PubMed id 17554300)1, 4 (Nature 2007)
    30. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. (PubMed id 17554260)1, 4 Todd J.A.... Clayton D.G. (Nat. Genet. 2007)
    31. An extended association screen in multiple sclerosis using 202 microsatellite markers targeting apoptosis-related genes does not reveal new predisposing factors. (PubMed id 16143043)1, 4 GAPdde R....Epplen J.T. (J Negat Results Biomed 2005)
    32. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    33. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    34. Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein. (PubMed id 12939402)1, 2 Li Y....Kufe D. (Mol. Cancer Res. 2003)
    35. Structure of the extracellular region of HER3 reveals an interdomain tether. (PubMed id 12154198)1, 2 Cho H.S. and Leahy D.J. (Science 2002)
    36. Regulation of the ErbB3 binding protein Ebp1 by protein kinase C. (PubMed id 11325528)1, 2 Lessor T.J. and Hamburger A.W. (Mol. Cell. Endocrinol. 2001)
    37. Molecular cloning and expression of an additional epidermal growth factor receptor-related gene. (PubMed id 2164210)1, 2 Plowman G.D.... Shoyab M. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    38. Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. (PubMed id 2687875)1, 2 Kraus M.H.... Aaronson S.A. (Proc. Natl. Acad. Sci. U.S.A. 1989)
    39. Dominant negative interference of transcription factor AP-2 causes inhibition of ErbB-3 expression and suppresses malignant cell growth. (PubMed id 11859873)1, 9 Zhu C.H. and Domann F.E. (Breast Cancer Res. Treat. 2002)
    40. Atypical expression of ErbB3 in myeloma cells: cross-talk between ErbB3 and the interferon-alpha signaling complex. (PubMed id 12789268)1, 9 Walters D.K....Jelinek D.F. (Oncogene 2003)
    41. A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy. (PubMed id 18632642)1, 9 Lee-Hoeflich S.T....Stern H.M. (Cancer Res. 2008)
    42. HER3 is a determinant for poor prognosis in melanoma. (PubMed id 18698037)1, 9 Reschke M....Ullrich A. (Clin. Cancer Res. 2008)
    43. Selective formation of ErbB-2/ErbB-3 heterodimers depends on the ErbB-3 affinity of epidermal growth factor-like ligands. (PubMed id 12556529)1, 9 Stortelers C....van Zoelen E.J. (J. Biol. Chem. 2003)
    44. Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin. (PubMed id 20103628)1, 9 Huang X....Liu B. (Cancer Res. 2010)
    45. Expression of heregulin, phosphorylated HER-2, HER-3 and HER-4 in HER-2 negative breast cancers. (PubMed id 19148499)1, 9 Haas S....BA1ttner R. (Oncol. Rep. 2009)
    46. Interaction of the p23/p198 protein with ErbB-3. (PubMed id 10095121)1, 9 Yoo J.Y. and Hamburger A.W. (Gene 1999)
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    573. Comprehensive copy number profiles of breast cancer cell model genomes. (PubMed id 16417655)9 Shadeo A. and Lam W.L. (Breast Cancer Res. 2006)
    574. ErbB3-dependent motility and intravasation in breast cancer metastasis. (PubMed id 16452197)9 Xue C....Segall J.E. (Cancer Res. 2006)
    575. Isoliquiritigenin (ISL) inhibits ErbB3 signaling in prostate cancer cells. (PubMed id 17473376)9 Jung J.I....Park J.H. (Biofactors 2006)
    576. Identification of metastasis-associated receptor tyrosine kinases in non-small cell lung cancer. (PubMed id 15753374)9 MA1ller-Tidow C....Serve H. (Cancer Res. 2005)
    577. HER2 overexpression increases sensitivity to gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, through inhibition of HER2/HER3 heterodimer formation in lung cancer cells. (PubMed id 15899817)9 Hirata A....Ono M. (Cancer Res. 2005)
    578. EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells. (PubMed id 16053920)9 Shimizu M....Weinstein I.B. (Biochem. Biophys. Res. Commun. 2005)
    579. Herceptin-induced inhibition of ErbB2 signaling involves reduced phosphorylation of Akt but not endocytic down-regulation of ErbB2. (PubMed id 15800944)9 Longva K.E....Madshus I.H. (Int. J. Cancer 2005)
    580. EGFR and Her-2 regulate the constitutive activation of NF-kappaB in PC-3 prostate cancer cells. (PubMed id 15880609)9 Le Page C....Saad F. (Prostate 2005)
    581. Role of HER2/HER3 co-receptor in breast carcinogenesis. (PubMed id 16556064)9 Way T.D. and Lin J.K. (Future Oncol 2005)
    582. Neuregulins rescue PC12-ErbB-4 cells from cell death induced by beta-amyloid peptide: involvement of PI3K and PKC. (PubMed id 15968086)9 Di Segni A....Pinkas-Kramarski R. (J. Mol. Neurosci. 2005)
    583. Cooperative cell-growth inhibition by combination treatment with ZD1839 (Iressa) and trastuzumab (Herceptin) in non-small-cell lung cancer. (PubMed id 16253759)9 Nakamura H....Shirouzu K. (Cancer Lett. 2005)
    584. Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer. (PubMed id 15665299)9 Amann J....Carbone D.P. (Cancer Res. 2005)
    585. EGFR kinase possesses a broad specificity for ErbB phosphorylation sites, and ligand increases catalytic-centre activity without affecting substrate binding affinity. (PubMed id 16122376)9 Fan Y.X....Johnson G.R. (Biochem. J. 2005)
    586. Therapeutic targeting of multiple signaling pathways in malignant pleural mesothelioma. (PubMed id 16020981)9 Mukohara T....Janne P.A. (Oncology 2005)
    587. The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand. (PubMed id 16203964)9 Bouyain S.... Leahy D.J. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    588. Antitumor activity of rapamycin in a transgenic mouse model of ErbB2-dependent human breast cancer. (PubMed id 15958580)9 Liu M....Abraham R.T. (Cancer Res. 2005)
    589. Multicenter, randomized phase II trial of oral CI-1033 for previously treated advanced ovarian cancer. (PubMed id 16110019)9 Campos S....Hirte H. (J. Clin. Oncol. 2005)
    590. Genistein inhibits insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells: a possible mechanism of the growth inhibitory effect of Genistein. (PubMed id 16379552)9 Kim E.J....Park J.H. (J Med Food 2005)
    591. Absence of HER4 expression predicts recurrence of ductal carcinoma in situ of the breast. (PubMed id 15788662)9 Barnes N.L....Bundred N.J. (Clin. Cancer Res. 2005)
    592. Activation of ErbB2 by overexpression or by transmembrane neuregulin results in differential signaling and sensitivity to herceptin. (PubMed id 16061662)9 Yuste L....Pandiella A. (Cancer Res. 2005)
    593. The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts. (PubMed id 16170026)9 Ihle N.T....Powis G. (Mol. Cancer Ther. 2005)
    594. H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent. (PubMed id 15713896)9 CarA^n R.W....Dent P. (Mol. Cancer Ther. 2005)
    595. ErbB2 overexpression in mammary cells upregulates VEGF through the core promoter. (PubMed id 15582599)9 Loureiro R.M....D'Amore P.A. (Biochem. Biophys. Res. Commun. 2005)
    596. Proliferation of human neuroblastomas mediated by the epidermal growth factor receptor. (PubMed id 16267010)9 Ho R....Brodeur G.M. (Cancer Res. 2005)
    597. Listeria monocytogenes produces a pro-invasive factor that signals via ErbB2/ErbB3 heterodimers. (PubMed id 15480783)9 Oliveira M.J....Leroy A. (J. Cancer Res. Clin. Oncol. 2005)
    598. Differential responses to doxorubicin-induced phosphorylation and activation of Akt in human breast cancer cells. (PubMed id 16168102)9 Li X....Fan Z. (Breast Cancer Res. 2005)
    599. Heregulin-induced activation of HER2 and HER3 increases androgen receptor transactivation and CWR-R1 human recurrent prostate cancer cell growth. (PubMed id 15755991)9 Gregory C.W....Earp H.S. (Clin. Cancer Res. 2005)
    600. Neuregulin-1 enhances survival of human astrocytic glioma cells. (PubMed id 15812817)9 Ritch P.S....Sontheimer H. (Glia 2005)
    601. Emerging treatments in oncology: focus on tyrosine kinase (erbB) receptor inhibitors. (PubMed id 14965154)9 Hamid O. (J Am Pharm Assoc (2003) 2004)
    602. The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells. (PubMed id 15059883)9 Nahta R....Esteva F.J. (Cancer Res. 2004)
    603. Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3. (PubMed id 15150091)9 Schaefer K.L....Poremba C. (Cancer Res. 2004)
    604. Blockade of epidermal growth factor- or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects. (PubMed id 15059917)9 Jackson J.G....Brattain M.G. (Cancer Res. 2004)
    605. Characterization of a novel cell line established from a patient with Herceptin-resistant breast cancer. (PubMed id 15634652)9 Tanner M....Isola J. (Mol. Cancer Ther. 2004)
    606. Mechanisms of resistance to Erbitux (anti-epidermal growth factor receptor) combination therapy in pancreatic adenocarcinoma cells. (PubMed id 15585383)9 Arnoletti J.P....Vickers S.M. (J. Gastrointest. Surg. 2004)
    607. Thymic myoid cells express high levels of muscle genes. (PubMed id 14975590)9 Mesnard-Rouiller L....Berrih-Aknin S. (J. Neuroimmunol. 2004)
    608. Outcome and human epidermal growth factor receptor (HER) 1-4 status in invasive breast carcinomas with proliferation indices evaluated by bromodeoxyuridine labelling. (PubMed id 15084248)9 Tovey S.M....Cooke T.G. (Breast Cancer Res. 2004)
    609. Role of HER receptors family in development and differentiation. (PubMed id 15254961)9 Casalini P....MAcnard S. (J. Cell. Physiol. 2004)
    610. Quantum dot ligands provide new insights into erbB/HER receptor-mediated signal transduction. (PubMed id 14704683)9 Lidke D.S....Jovin T.M. (Nat. Biotechnol. 2004)
    611. Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. (PubMed id 15314180)9 Wu X.... Carraway K.L. III (Mol. Cell. Biol. 2004)
    612. Epidermal growth factor receptor inhibitors: a new prospective in the treatment of lung cancer. (PubMed id 15032719)9 Tiseo M....Ardizzoni A. (Curr Med Chem Anticancer Agents 2004)
    613. Biomarkers in non-small cell lung cancer prevention. (PubMed id 15452456)9 Hilbe W....WAPll E. (Eur. J. Cancer Prev. 2004)
    614. A structure-based model for ligand binding and dimerization of EGF receptors. (PubMed id 14732694)9 Klein P....Schlessinger J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    615. Frequent overexpression of multiple ErbB receptors by head and neck squamous cell carcinoma contrasts with rare antibody immunity in patients. (PubMed id 15476268)9 Bei R....Muraro R. (J. Pathol. 2004)
    616. Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway. (PubMed id 14602723)9 Way T.D....Lin J.K. (J. Biol. Chem. 2004)
    617. Roles of mitogen-activated protein kinase and phosphoinositide 3'-kinase in ErbB2/ErbB3 coreceptor-mediated heregulin signaling. (PubMed id 12651161)9 Vijapurkar U....Koland J.G. (Exp. Cell Res. 2003)
    618. [Gene expression profiles of protein kinases and phosphatases obtained by hybridization with cDNA arrays: molecular portrait of human prostate carcinoma]. (PubMed id 12624952)9 Kniazev I.u.P....Kniazev P.G. (Mol. Biol. (Mosk.) 2003)
    619. The EGF receptor family--multiple roles in proliferation, differentiation, and neoplasia with an emphasis on HER4. (PubMed id 12813928)9 Earp H.S....Sartor C.I. (Trans. Am. Clin. Climatol. Assoc. 2003)
    620. ErbBs in mammary development. (PubMed id 12648468)9 Stern D.F. (Exp. Cell Res. 2003)
    621. Neuregulin-1 and erbB4 immunoreactivity is associated with neuritic plaques in Alzheimer disease brain and in a transgenic model of Alzheimer disease. (PubMed id 12528817)9 Chaudhury A.R....Carroll S.L. (J. Neuropathol. Exp. Neurol. 2003)
    622. Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells. (PubMed id 12529413)9 Labriola L....Elizalde P.V. (Mol. Cell. Biol. 2003)
    623. Inhibition of heregulin signaling by an aptamer that preferentially binds to the oligomeric form of human epidermal growth factor receptor-3. (PubMed id 12874383)9 Chen C.H....Landgraf R. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    624. Mechanism of action of anti-HER2 monoclonal antibodies: scientific update on trastuzumab and 2C4. (PubMed id 12908564)9 Albanell J....GascA^n P. (Adv. Exp. Med. Biol. 2003)
    625. Herstatin inhibits heregulin-mediated breast cancer cell growth and overcomes tamoxifen resistance in breast cancer cells that overexpress HER-2. (PubMed id 14603258)9 Jhabvala-Romero F....Clinton G.M. (Oncogene 2003)
    626. Betacellulin and amphiregulin induce upregulation of cyclin D1 and DNA synthesis activity through differential signaling pathways in vascular smooth muscle cells. (PubMed id 12869389)9 Shin H.S....Koh G.Y. (Circ. Res. 2003)
    627. Blockage of heregulin expression inhibits tumorigenicity and metastasis of breast cancer. (PubMed id 12569369)9 Tsai M.S....Lupu R. (Oncogene 2003)
    628. Disabling receptor ensembles with rationally designed interface peptidomimetics. (PubMed id 12011054)9 Berezov A....Murali R. (J. Biol. Chem. 2002)
    629. Epidermal growth factor receptor family in lung cancer and premalignancy. (PubMed id 11894009)9 Franklin W.A....Bunn P.A. (Semin. Oncol. 2002)
    630. C-erbB receptors in squamous cell carcinomas of the head and neck: clinical significance and correlation with matrix metalloproteinases and vascular endothelial growth factors. (PubMed id 11755824)9 O-charoenrat P....Eccles S.A. (Oral Oncol. 2002)
    631. The effectiveness of double-stranded short inhibitory RNAs (siRNAs) may depend on the method of transfection. (PubMed id 12568315)9 Walters D.K. and Jelinek D.F. (amp 2002)
    632. Estrogen-related receptor alpha and estrogen-related receptor gamma associate with unfavorable and favorable biomarkers, respectively, in human breast cancer. (PubMed id 12438245)9 Ariazi E.A....Mertz J.E. (Cancer Res. 2002)
    633. Differential regulation of tumor angiogenesis by distinct ErbB homo- and heterodimers. (PubMed id 12429844)9 Yen L....Alaoui-Jamali M.A. (Mol. Biol. Cell 2002)
    634. Replacement of N-terminal portions of TGF-alpha with corresponding heregulin sequences affects ligand-induced receptor signaling and intoxication of tumor cells by chimeric growth-factor toxins. (PubMed id 11774287)9 Schmidt M. and Wels W. (Int. J. Cancer 2002)
    635. Type 1 protein tyrosine kinases in breast carcinoma: a review. (PubMed id 12184370)9 Suo Z. and Nesland J.M. (Ultrastruct Pathol 2002)
    636. Epidermal growth factor receptor signaling pathways are associated with tumorigenesis in the Nf1:p53 mouse tumor model. (PubMed id 12154062)9 Li H....DeClue J.E. (Cancer Res. 2002)
    637. Muscarinic receptors mediate phospholipase C-dependent activation of protein kinase B via Ca2+, ErbB3, and phosphoinositide 3-kinase in 1321N1 astrocytoma cells. (PubMed id 11694521)9 Tang X....Downes C.P. (J. Biol. Chem. 2002)
    638. Autocrine heregulin generates growth factor independence and blocks apoptosis in colon cancer cells. (PubMed id 11791178)9 Venkateswarlu S....Brattain M.G. (Oncogene 2002)
    639. Transactivation of ErbB2 and ErbB3 by tumor necrosis factor-alpha and anisomycin leads to impaired insulin signaling through serine/threonine phosphorylation of IRS proteins. (PubMed id 11779863)9 Hemi R....Kanety H. (J. Biol. Chem. 2002)
    640. Heregulin up-regulates heat shock protein-70 expression in breast cancer cells. (PubMed id 12174871)9 Mandal M....Kumar R. (Anticancer Res. 2002)
    641. Human betacellulin structure modeled from other members of EGF family. (PubMed id 12111392)9 LA^pez-TorrejA^n I....Oliva B. (J Mol Model 2002)
    642. Functions of epidermal growth factor-like growth factors during human urothelial reepithelialization in vitro and the role of erbB2. (PubMed id 12202942)9 Bindels Boer W.I. (Urol. Res. 2002)
    643. Characterization of the malignant melanoma of soft-parts cell line GG-62 by expression analysis using DNA microarrays. (PubMed id 12021921)9 Schaefer K.L....Dockhorn-Dworniczak B. (Virchows Arch. 2002)
    644. Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors. (PubMed id 12134143)9 Camenisch T.D....McDonald J.A. (Nat. Med. 2002)
    645. Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2. (PubMed id 11739740)9 EsparA-s-Ogando A....Pandiella A. (Mol. Cell. Biol. 2002)
    646. The peroxisome proliferator-activated receptor gamma is an inhibitor of ErbBs activity in human breast cancer cells. (PubMed id 11739643)9 Pignatelli M....Perez-Castillo A. (J. Cell. Sci. 2001)
    647. Assessment of differential expression of oncogenes in gastric adenocarcinoma by fluorescent multiplex RT-PCR assay. (PubMed id 11678335)9 Rajcevic U....Komel R. (Pflugers Arch. 2001)
    648. Intracellular expression of the truncated extracellular domain of c-erbB-3/HER3. (PubMed id 11369513)9 Srinivasan R....Gullick W.J. (Cell. Signal. 2001)
    649. The expression of HPV-16 E5 protein in squamous neoplastic changes in the uterine cervix. (PubMed id 11287752)9 Chang J.L....Chen S.L. (J. Biomed. Sci. 2001)
    650. Ribozyme targeting of HER-2 inhibits pancreatic cancer cell growth in vivo. (PubMed id 11527697)9 Thybusch-Bernhardt A....Juhl H. (Eur. J. Cancer 2001)
    651. Isolation of the melanoma-associated antigen p23 using antibody phage display. (PubMed id 11123321)9 Li J....Herlyn D. (J. Immunol. 2001)
    652. [The c-erbB-related oncoproteins in normal placenta and in gestational trophoblastic diseases (in vitro study)]. (PubMed id 11424588)9 FA1lAPp V....Doszpod J. (Orv Hetil 2001)
    653. Characterization of ten newly-derived human head and neck squamous carcinoma cell lines with special reference to c-erbB proto-oncogene expression. (PubMed id 11497283)9 O-Charoenrat P....Eccles S. (Anticancer Res. 2001)
    654. Expression of EGFR family and steroid hormone receptors in ductal carcinoma in situ of the breast. (PubMed id 11758715)9 Suo Z....Nesland J.M. (Ultrastruct Pathol 2001)
    655. Signaling molecules implicated in heregulin induction of growth arrest and apoptosis. (PubMed id 11605034)9 Guerra-Vladusic F.K....Lupu R. (Oncol. Rep. 2001)
    656. The tyrosine kinase inhibitor ZD1839 (&quot;Iressa&quot;) inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. (PubMed id 11585753)9 Moasser M.M....Rosen N. (Cancer Res. 2001)
    657. CI-1033, a pan-erbB tyrosine kinase inhibitor. (PubMed id 11706399)9 Slichenmyer W.J....Fry D.W. (Semin. Oncol. 2001)
    658. Differential utilization and localization of ErbB receptor tyrosine kinases in skin compared to normal and malignant keratinocytes. (PubMed id 11571634)9 Stoll S.W....Elder J.T. (Neoplasia 2001)
    659. The transmembrane heregulin precursor is functionally active. (PubMed id 11495899)9 Aguilar Z. and Slamon D.J. (J. Biol. Chem. 2001)
    660. Expression of herstatin, an autoinhibitor of HER-2/neu, inhibits transactivation of HER-3 by HER-2 and blocks EGF activation of the EGF receptor. (PubMed id 11526509)9 Azios N.G....Clinton G.M. (Oncogene 2001)
    661. The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells. (PubMed id 11313882)9 Bowers G....Schmidt-Ullrich R.K. (Oncogene 2001)
    662. Human EGF receptor (HER) family and heregulin members are differentially expressed in epidermal keratinocytes and modulate differentiation. (PubMed id 11716544)9 De Potter I.Y....Pittelkow M.R. (Exp. Cell Res. 2001)
    663. A novel role of neuregulin in skeletal muscle. Neuregulin stimulates glucose uptake, glucose transporter translocation, and transporter expression in muscle cells. (PubMed id 11278386)9 SuA!rez E....GumA! A. (J. Biol. Chem. 2001)
    664. Ligand-mediated cytolysis of tumor cells: use of heregulin-zeta chimeras to redirect cytotoxic T lymphocytes. (PubMed id 10678365)9 Muniappan A....Talib S. (Cancer Gene Ther. 2000)
    665. TCDD elevates erbB2 expression and signaling in T47D cells by reversing serum potentiation of estrogen receptor activity, independent of estrogen levels and enhanced ER down-regulation. (PubMed id 11162886)9 Angus W.G....Jefcoate C.R. (Mol. Cell. Endocrinol. 2000)
    666. Cell death induced by TNF or serum starvation is independent of ErbB receptor signaling in MCF-7 breast carcinoma cells. (PubMed id 10797281)9 Egeblad M. and JAoAottelAo M. (Int. J. Cancer 2000)
    667. Relationship of c-myc and erbB oncogene family gene aberrations and other selected factors to ex vivo chemosensitivity of ovarian cancer in the modified ATP-chemosensitivity assay. (PubMed id 10961689)9 Vogt U....Schlotter C.M. (Acta Biochim. Pol. 2000)
    668. Molecular mechanisms underlying ErbB2/HER2 action in breast cancer. (PubMed id 11156523)9 Harari D. and Yarden Y. (Oncogene 2000)
    669. Ectopic expression of the ErbB-3 binding protein ebp1 inhibits growth and induces differentiation of human breast cancer cell lines. (PubMed id 10797306)9 Lessor T.J....Hamburger A.W. (J. Cell. Physiol. 2000)
    670. Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers. (PubMed id 10749108)9 Srinivasan R....Gullick W.J. (Cancer Res. 2000)
    671. Heregulin-beta is especially potent in activating phosphatidylinositol 3-kinase in nontransformed human mammary epithelial cells. (PubMed id 10797304)9 Ram T.G....Ethier S.P. (J. Cell. Physiol. 2000)
    672. Differential signaling by an anti-p185(HER2) antibody and heregulin. (PubMed id 10910064)9 Le X.F....Bast R.C. (Cancer Res. 2000)
    673. Role of HER2 gene overexpression in breast carcinoma. (PubMed id 10623878)9 MAcnard S....Pupa S.M. (J. Cell. Physiol. 2000)
    674. Expression of epidermal growth factor receptor-related family products in gestational trophoblastic diseases and normal placenta and its relationship with development of postmolar tumor. (PubMed id 10831347)9 Tuncer Z.S....Berkowitz R.S. (Gynecol. Oncol. 2000)
    675. Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis. (PubMed id 10918604)9 Yen L....Alaoui-Jamali M.A. (Oncogene 2000)
    676. Ethanol enhances erbB-mediated migration of human breast cancer cells in culture. (PubMed id 11079160)9 Luo J. and Miller M.W. (Breast Cancer Res. Treat. 2000)
    677. EGF activates ErbB-2 and stimulates phosphatidylinositol 3-kinase in human airway smooth muscle cells. (PubMed id 9950886)9 Krymskaya V.P....Panettieri R.A. (Am. J. Physiol. 1999)
    678. Expression of P185erbB-2, P160erbB-3, P180erbB-4, and heregulin alpha in human normal bronchial epithelial and lung cancer cell lines. (PubMed id 10226586)9 al Moustafa A.E....O'Connor-McCourt M. (Anticancer Res. 1999)
    679. Heregulin beta1-activated phosphatidylinositol 3-kinase enhances aggregation of MCF-7 breast cancer cells independent of extracellular signal-regulated kinase. (PubMed id 10197638)9 Tan M....Yu D. (Cancer Res. 1999)
    680. Regulation of cyclooxygenase-2 pathway by HER2 receptor. (PubMed id 9927187)9 Vadlamudi R....Kumar R. (Oncogene 1999)
    681. Phosphotyrosine binding domains of Shc and insulin receptor substrate 1 recognize the NPXpY motif in a thermodynamically distinct manner. (PubMed id 10037694)9 Farooq A....Zhou M.M. (J. Biol. Chem. 1999)
    682. Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase. (PubMed id 10353604)9 Elenius K....Klagsbrun M. (Oncogene 1999)
    683. NDF/heregulin-induced cell cycle changes and apoptosis in breast tumour cells: role of PI3 kinase and p38 MAP kinase pathways. (PubMed id 10376522)9 Daly J.M....Hynes N.E. (Oncogene 1999)
    684. Receptor tyrosine kinase and p16/CDKN2 expression in a case of tripe palms associated with non-small-cell lung cancer. (PubMed id 10640836)9 KrAohn G....Peter R.U. (Dermatology (Basel) 1999)
    685. Evaluation of biomarker modulation by fenretinide in prostate cancer patients. (PubMed id 10325501)9 Urban D....Grizzle W. (Eur. Urol. 1999)
    686. Neu differentiation factor stimulates phosphorylation and activation of the Sp1 transcription factor. (PubMed id 10022883)9 Alroy I....Yarden Y. (Mol. Cell. Biol. 1999)
    687. Formation of distinct signalling complexes involving phosphatidylinositol 3-kinase activity with stimulation of epidermal growth factor or insulin-like growth factor-I in human skin fibroblasts. (PubMed id 9886492)9 Takahashi Y....Kadowaki T. (J. Cell. Physiol. 1999)
    688. ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases. (PubMed id 10358079)9 Olayioye M.A.... Hynes N.E. (J. Biol. Chem. 1999)
    689. Binding specificities and affinities of egf domains for ErbB receptors. (PubMed id 10214951)9 Jones J.T....Sliwkowski M.X. (FEBS Lett. 1999)
    690. Neuregulin-increased expression of acetylcholine receptor epsilon-subunit gene requires ErbB interaction with Shc. (PubMed id 10582594)9 Won S....Mei L. (J. Neurochem. 1999)
    691. Biologic effects of heregulin/neu differentiation factor on normal and malignant human breast and ovarian epithelial cells. (PubMed id 10557094)9 Aguilar Z....Slamon D.J. (Oncogene 1999)
    692. The expression of type I growth factor receptors in the squamous neoplastic changes of uterine cervix. (PubMed id 10094882)9 Chang J.L....Chen S.L. (Gynecol. Oncol. 1999)
    693. Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase. (PubMed id 10348342)9 Harari D....Yarden Y. (Oncogene 1999)
    694. Ribozyme-mediated down-regulation of ErbB-4 in estrogen receptor-positive breast cancer cells inhibits proliferation both in vitro and in vivo. (PubMed id 10537315)9 Tang C.K....Lippman M.E. (Cancer Res. 1999)
    695. Laminin receptor alpha6beta4 integrin is highly expressed in ENU-induced glioma in rat. (PubMed id 10088672)9 Previtali S.C....Wrabetz L. (Glia 1999)
    696. Granulosa cell tumors express erbB4 and are sensitive to the cytotoxic action of heregulin-beta2/PE40. (PubMed id 9581810)9 Furger C....Sutherland R.L. (Cancer Res. 1998)
    697. Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers. (PubMed id 9628875)9 Lenferink A.E....Yarden Y. (EMBO J. 1998)
    698. Type 1 protein tyrosine kinases in benign and malignant breast lesions. (PubMed id 9870145)9 Suo Z....Nesland J.M. (Histopathology 1998)
    699. Inhibition of cell proliferation by 17beta-estradiol and heregulin beta1 in estrogen receptor negative human breast carcinoma cell lines. (PubMed id 9877030)9 Yoo J.Y....Hamburger A.W. (Breast Cancer Res. Treat. 1998)
    700. Synergistic regulation of Schwann cell proliferation by heregulin and forskolin. (PubMed id 9774641)9 Rahmatullah M....Carey D.J. (Mol. Cell. Biol. 1998)
    701. Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells. (PubMed id 9590694)9 Qiu Y....Kung H.J. (Nature 1998)
    702. Signal transduction by epidermal growth factor and heregulin via the kinase-deficient ErbB3 protein. (PubMed id 9693119)9 Kim H.H....Koland J.G. (Biochem. J. 1998)
    703. Targeted expression of activated erbB-2 to the epidermis of transgenic mice elicits striking developmental abnormalities in the epidermis and hair follicles. (PubMed id 9563851)9 Xie W....Kudlow J.E. (amp 1998)
    704. Heparin-binding EGF-like growth factor in the human prostate: synthesis predominantly by interstitial and vascular smooth muscle cells and action as a carcinoma cell mitogen. (PubMed id 9518259)9 Freeman M.R....Klagsbrun M. (J. Cell. Biochem. 1998)
    705. Alternative intracellular routing of ErbB receptors may determine signaling potency. (PubMed id 9593726)9 Waterman H....Yarden Y. (J. Biol. Chem. 1998)
    706. Cytotoxic activity of epidermal growth factor-genistein against breast cancer cells. (PubMed id 9563884)9 Uckun F.M....Myers D.E. (Clin. Cancer Res. 1998)
    707. Recombinant heregulin-Pseudomonas exotoxin fusion proteins: interactions with the heregulin receptors and antitumor activity in vivo. (PubMed id 9563895)9 Yang D....Lippman M.E. (Clin. Cancer Res. 1998)
    708. ErbB tyrosine kinases and the two neuregulin families constitute a ligand-receptor network. (PubMed id 9742126)9 Pinkas-Kramarski R....Alamandi M. (Mol. Cell. Biol. 1998)
    709. The oncogenic ErbB-2/ErbB-3 heterodimer is a surrogate receptor of the epidermal growth factor and betacellulin. (PubMed id 9546426)9 Pinkas-Kramarski R....Yarden Y. (Oncogene 1998)
    710. Biological response to ErbB ligands in nontransformed cell lines correlates with a specific pattern of receptor expression. (PubMed id 9832411)9 Sundaresan S....Mather J.P. (Endocrinology 1998)
    711. Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer: amphiregulin and microvessel count are independent prognostic indicators of survival. (PubMed id 9516978)9 Fontanini G....Ciardiello F. (Clin. Cancer Res. 1998)
    712. The type 1 growth factor receptor family: new ligands and receptors and their role in breast cancer. (PubMed id 10066071)9 Gullick W.J. and Srinivasan R. (Breast Cancer Res. Treat. 1998)
    713. Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus. (PubMed id 9199335)9 Busfield S.J....Gearing D.P. (Mol. Cell. Biol. 1997)
    714. Activation of erbB2 and c-src in phorbol ester-treated mouse epidermis: possible role in mouse skin tumor promotion. (PubMed id 9136987)9 Xian W....DiGiovanni J. (Oncogene 1997)
    715. Heregulin and agonistic anti-p185(c-erbB2) antibodies inhibit proliferation but increase invasiveness of breast cancer cells that overexpress p185(c-erbB2): increased invasiveness may contribute to poor prognosis. (PubMed id 9815853)9 Xu F.J....Bast R.C. (Clin. Cancer Res. 1997)
    716. Heregulin-stimulated acetylcholine receptor gene expression in muscle: requirement for MAP kinase and evidence for a parallel inhibitory pathway independent of electrical activity. (PubMed id 9049301)9 Altiok N....Changeux J.P. (EMBO J. 1997)
    717. Epidermal growth factor and betacellulin mediate signal transduction through co-expressed ErbB2 and ErbB3 receptors. (PubMed id 9312020)9 Alimandi M....Pierce J.H. (EMBO J. 1997)
    718. Bivalence of EGF-like ligands drives the ErbB signaling network. (PubMed id 9305636)9 Tzahar E....Yarden Y. (EMBO J. 1997)
    719. Characterization of human breast adenocarcinoma SK-BR-3 cells resistant to doxorubicin. (PubMed id 9372856)9 Osmak M....Skrk J. (Neoplasma 1997)
    720. Phosphatidylinositol 3-kinase mediates heregulin-induced growth inhibition in human epithelial cells. (PubMed id 9216687)9 Hamburger A.W. and Yoo J.Y. (Anticancer Res. 1997)
    721. Altered gene expression in drug-resistant human breast cancer cells. (PubMed id 9815641)9 Wosikowski K....Bates S.E. (Clin. Cancer Res. 1997)
    722. Association of csk-homologous kinase (CHK) (formerly MATK) with HER-2/ErbB-2 in breast cancer cells. (PubMed id 8999872)9 Zrihan-Licht S....Avraham H. (J. Biol. Chem. 1997)

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    Entrez Gene: 2065 HGNC: 3431 AceView: ERBB3 Ensembl:ENSG00000065361 euGenes: HUgn2065
    ECgene: ERBB3 Kegg: 2065 H-InvDB: ERBB3

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    PharmGKB entry for ERBB3 Pharmacogenomics, SNPs, Pathways
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