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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ERBB3 Gene

protein-coding   GIFtS: 76
GCID: GC12P056473

V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog...

(Previous name: lethal congenital contracture syndrome 2)
(Previous symbol: LCCS2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 31 2     c-erbB-32
LCCS21 2 5     c-erbB32
Proto-Oncogene-Like Protein C-ErbB-32 3     erbB3-S2
Tyrosine Kinase-Type Cell Surface Receptor HER32 3     p180-ErbB32
HER32 3     p45-sErbB32
EC 2.7.10.13 8     p85-sErbB32
Lethal Congenital Contracture Syndrome 21     Receptor Tyrosine-Protein Kinase ErbB-32
ErbB-32     EC 2.7.108
MDA-BF-12     

External Ids:    HGNC: 34311   Entrez Gene: 20652   Ensembl: ENSG000000653617   OMIM: 1901515   UniProtKB: P218603   

Export aliases for ERBB3 gene to outside databases

Previous GC identifers: GC12M056386 GC12M056841 GC12P056190 GC12P054760 GC12P053512


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ERBB3 Gene:
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases.
This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can
bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form
heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to
the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or
overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast
tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One
isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity
of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly
characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for ERBB3 Gene: 
ERBB3 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3) is a protein-coding gene. Diseases associated with ERBB3 include lethal congenital contracture syndrome 2, and lethal congenital contractural syndrome 2, and among its related super-pathways are ErbB signaling pathway and GRB2 events in ERBB2 signaling. GO annotations related to this gene include transmembrane signaling receptor activity and protein homodimerization activity. An important paralog of this gene is SYK.

UniProtKB/Swiss-Prot: ERBB3_HUMAN, P21860
Function: Binds and is activated by neuregulins and NTAK

summary for ERBB3 Gene:
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members
of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4).
EGFR signaling is initiated by ligand binding to the extracellular ligand binding domain. This initiates
receptor homo-/hetero-dimerization and autophosphorylation by the intracellular kinase domain, resulting in
receptor activation. Following activation, phosphorylation of cytoplasmic substrates occurs and a signaling
cascade is initiated that drives many cellular responses, including changes in gene expression, cytoskeletal
rearrangement, anti-apoptosis and increased cell proliferation.

Gene Wiki entry for ERBB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ERBB3 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ERBB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ERBB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ERBB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13

ERBB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ERBB3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P056473:  view genomic region     (about GC identifiers)

Start:
56,473,641 bp from pter      End:
56,497,291 bp from pter
Size:
23,651 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ERBB3_HUMAN, P21860 (See protein sequence)
Recommended Name: Receptor tyrosine-protein kinase erbB-3 precursor  
Size: 1342 amino acids; 148098 Da
Subunit: Monomer and homodimer. Heterodimer with each of the other ERBB receptors (Potential). Interacts with
CSPG5, PA2G4, GRB7 and MUC1
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted
Developmental stage: Overexpressed in a subset of human mammary tumors
5 PDB 3D structures from and Proteopedia for ERBB3:
1M6B (3D)        2L9U (3D)        3KEX (3D)        3LMG (3D)        3P11 (3D)    
Secondary accessions: A8K6L6 B4DIK7 B4DV32 E9PDT8 Q9BUD7
Alternative splicing: 5 isoforms:  P21860-1   P21860-2   P21860-3   P21860-4   P21860-5   

Explore the universe of human proteins at neXtProt for ERBB3: NX_P21860

Explore proteomics data for ERBB3 at MOPED 

Post-translational modifications:

  • UniProtKB: Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of
    phosphatidylinositol 3-kinase (By similarity). Subject to autophosphorylation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P21860

  • 4/22 DME Specific Peptides for ERBB3 (P21860) (see all 22)
     YGVTVWE  DTDCFAC  KETELRK  TCNGSGS 

    ERBB3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ERBB3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001005915.1  NP_001973.2  

    ENSEMBL proteins: 
     ENSP00000448636   ENSP00000449138   ENSP00000267101   ENSP00000415753   ENSP00000448671  
     ENSP00000448483   ENSP00000447510   ENSP00000449713   ENSP00000408340   ENSP00000448946  
     ENSP00000449129   ENSP00000448729   ENSP00000399178  
    Reactome Protein details: P21860
    Human Recombinant Protein Products for ERBB3: 
    EMD Millipore Purified and/or Recombinant ERBB3 Protein
    R&D Systems Recombinant & Natural Proteins for ERBB3 (ErbB3/Her3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for ERBB3
    OriGene Protein Over-expression Lysate for ERBB3
    OriGene MassSpec for ERBB3 
    OriGene Custom Protein Services for ERBB3
    GenScript Purified and Recombinant Proteins for ERBB3
    Novus Biologicals ERBB3 Proteins
    Novus Biologicals ERBB3 Lysates
    Sino Biological Recombinant Protein for ERBB3
    Sino Biological Cell Lysate for ERBB3 
    ProSpec Recombinant Protein for ERBB3
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA11389077
    GO:0005886plasma membrane TAS17701904
    GO:0005887integral to plasma membrane TAS2687875
    GO:0016020membrane ----
    GO:0016021integral to membrane ----

    ERBB3 for ontologies           About GeneDecksing



    ERBB3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ERBB3
    R&D Systems Antibodies for ERBB3 (ErbB3/Her3)
    Cell Signaling Technology (CST) Antibodies for ERBB3  (HER3)
    OriGene Antibodies for ERBB3
    OriGene Custom Antibody Services for ERBB3
    GenScript Superior Antibodies for ERBB3
    Novus Biologicals ERBB3 Antibodies
    Abcam antibodies for ERBB3
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for ERBB3
    LSBio Antibodies in human, mouse, rat for ERBB3 

    Assay Products for ERBB3: 
    EMD Millipore Kits and Assays for the Analysis of ERBB3
    OriGene Custom Assay Services for ERBB3
    R&D Systems ELISAs for ERBB3 (ErbB3/Her3)         (see all)
    GenScript Custom Assay Services for ERBB3
    Cell Signaling Technology (CST) Sandwich ELISA Kits for ERBB3 (HER3)
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 
    ErbB (epidermal growth factor) receptor family

    5/9 InterPro protein domains (see all 9):
     IPR006212 Furin_repeat
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR000494 EGF_rcpt_L
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P21860

    ProtoNet protein and cluster: P21860

    4 Blocks protein domains:
    IPB000494 Epidermal growth-factor receptor (EGFR)
    IPB006211 Furin-like cysteine rich region
    IPB006212 Furin-like repeat
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: ERBB3_HUMAN, P21860
    Domain: The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing
    proteins
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily
    Similarity: Contains 1 protein kinase domain


    ERBB3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ERBB3_HUMAN, P21860
    Function: Binds and is activated by neuregulins and NTAK
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for ERBB3:
    avian erythroblastic leukemia,viral (v-erb-b) oncogene homolog 3,heregulin beta 1 receptor,signal transducer
    receptor,heterodimerizing with the ligand less recetpor ERBB2

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713NOT protein tyrosine kinase activity IDA7556068
    GO:0004714transmembrane receptor protein tyrosine kinase activity ----
    GO:0004716receptor signaling protein tyrosine kinase activity ----
    GO:0004888transmembrane signaling receptor activity ISS7514177
         
    ERBB3 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for ERBB3:
     Decreased substrate adherent c  Decreased viability  Increased cell death HMECs cel  Synthetic lethal with c-Myc af 

         15/17 MGI mutant phenotypes (inferred from 11 alleles(MGI details for Erbb3) (see all 17):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  homeostasis/metabolism  immune system  integument 
     mortality/aging  muscle  nervous system  normal  pigmentation 

    ERBB3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ERBB3: Erbb3tm1.1Dwt Erbb3tm1Gne Erbb3tm1Cbm Erbb3tm2Cbm

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ERBB3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ERBB3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ERBB3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ERBB3 

    miRNA
    Products:
        
    miRTarBase miRNAs that target ERBB3:
    hsa-mir-125a-5p (MIRT005117), hsa-mir-125b (MIRT002938), hsa-mir-205 (MIRT003659)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ERBB3
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate ERBB3 (see all 57):
    hsa-miR-106a hsa-miR-301a hsa-miR-500a hsa-miR-766 hsa-miR-519a hsa-miR-877* hsa-miR-93 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidERBB3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ERBB3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ERBB3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ERBB3
    Sirion Biotech Customized adenovirus for overexpression of ERBB3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ERBB3 (see all 16)
    OriGene ORF clones in mouse, rat for ERBB3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ERBB3 (NM_001005915)
    Sino Biological Human cDNA Clone for ERBB3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERBB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERBB3
    Sirion Biotech Customized lentivirus for stable overexpression of ERBB3 
                         Customized lentivirus expression plasmids for stable overexpression of ERBB3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ERBB3
    Search LifeMap BioReagents cell lines for ERBB3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERBB3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ERBB3 About   (see all 42)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52
    2SHC1 events in ERBB2 signaling
    SHC1 events in ERBB2 signaling0.92
    ErbB receptor signaling network0.34
    3Signaling by FGFR
    Downstream signaling of activated FGFR0.92
    Downstream signal transduction0.90
    Signaling by FGFR0.92
    Signaling by PDGF0.85
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.84
    DAP12 signaling0.91
    Signaling by EGFR in Cancer0.83
    4PIP3 activates AKT signaling
    GAB1 signalosome0.93
    PI3K events in ERBB2 signaling0.88
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    PIP3 activates AKT signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    PI3K/AKT Signaling in Cancer0.88
    Signaling by SCF-KIT0.72
    5GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for ERBB3
        Apoptosis and survival Role of CDK5 in neuronal death and survival
    Development ERBB-family signaling
    Development Ligand-independent activation of ESR1 and ESR2

    1 R&D Systems Pathway for ERBB3
        Akt Signaling Pathway

    5/35 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ERBB3 (see all 35)
        Paxillin Interactions
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    JNK Pathway
    Tec Kinases Signaling

    1 Cell Signaling Technology (CST) Pathway for ERBB3
        Tyrosine Kinases / Adaptors

    4 Tocris Bioscience Pathways for ERBB3
        Akt Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    MAPK Pathway

    3 GeneGo (Thomson Reuters) Pathways for ERBB3
        Development ERBB-family signaling
    Development Ligand-independent activation of ESR1 and ESR2
    Apoptosis and survival Role of CDK5 in neuronal death and survival

    5/7 BioSystems Pathways for ERBB3 (see all 7)
        Heart Development
    ErbB signaling pathway
    Signaling Pathways in Glioblastoma
    IL-6 Signaling Pathway
    ErbB receptor signaling network

    1 Sino Biological Pathway for ERBB3 
        EGFR Signaling Pathway

    5/34        Reactome Pathways for ERBB3 (see all 34)
        Signaling by EGFR in Cancer
    Downregulation of ERBB2:ERBB3 signaling
    Downstream signal transduction
    Signal Transduction
    Signaling by PDGF

    1 PharmGKB Pathway for ERBB3
        EGFR Inhibitor Pathway, Pharmacodynamics

    5         Kegg Pathways  (Kegg details for ERBB3):
        ErbB signaling pathway
    Calcium signaling pathway
    Endocytosis
    Proteoglycans in cancer
    MicroRNAs in cancer


    ERBB3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ERBB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/101 Interacting proteins for ERBB3 (P218601, 2, 3 ENSP000002671014) via UniProtKB, MINT, STRING, and/or I2D (see all 101)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279861, 2, 3, ENSP000002743354EBI-720706,EBI-79464 MINT-74605 MINT-74614 MINT-74600 MINT-74611 MINT-74604 MINT-74616 MINT-74613 MINT-74601 MINT-74612 MINT-74617 MINT-74615 MINT-74597 MINT-74602 MINT-74596 MINT-74603 I2D: score=7 STRING: ENSP00000274335
    PIK3R3Q925692, 3, ENSP000002627414MINT-74643 MINT-74669 MINT-74652 MINT-74647 MINT-74651 MINT-74656 MINT-74653 MINT-74672 MINT-74644 MINT-74668 MINT-74646 MINT-74645 MINT-74667 MINT-74654 MINT-74666 MINT-74665 MINT-74657 MINT-74670 MINT-74655 MINT-74671 I2D: score=2 STRING: ENSP00000262741
    ABL2P426842, 3, ENSP000003565954MINT-74450 MINT-74445 MINT-74452 MINT-74446 MINT-74447 MINT-74451 MINT-74448 MINT-74453 MINT-74449 MINT-74454 I2D: score=2 STRING: ENSP00000356595
    PIK3R2O004592, 3, ENSP000002222544MINT-74627 MINT-74618 MINT-61512 MINT-74629 MINT-74637 MINT-61520 MINT-74625 MINT-74638 MINT-61513 MINT-74624 MINT-74636 MINT-74633 MINT-74628 MINT-61519 MINT-74626 MINT-74639 MINT-61516 MINT-74635 MINT-74634 MINT-61517 I2D: score=5 STRING: ENSP00000222254
    GRB7Q144512, 3, ENSP000003107714MINT-74546 MINT-74548 MINT-74545 MINT-74547 MINT-8027964 MINT-8034751 I2D: score=5 STRING: ENSP00000310771
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003197endocardial cushion development IEA--
    GO:0006468protein phosphorylation ----
    GO:0007162negative regulation of cell adhesion IDA7556068
    GO:0007165signal transduction IDA10572067
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway ISS7514177

    ERBB3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ERBB3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ERBB3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Iressa Orally active, selective EGFR inhibitor [184475-35-2]
    AG 490 EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor [133550-30-8]
    JNJ 28871063 hydrochloridePotent ErbB receptor family inhibitor[944341-54-2]
    AG 1478 hydrochlorideHighly potent EGFR-kinase inhibitor[153436-53-4]
    GenisteinEGFR kinase inhibitor. Also estrogen and PPARgamma ligand[446-72-0]

    2 HMDB Compounds for ERBB3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 IUPHAR Ligands for ERBB3 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian))    About this table 
    LigandTypeActionAffinityPubmed IDs
    neuregulin-1
    NoneNone--
    neuregulin-2
    NoneNone--

    10/47 Novoseek inferred chemical compound relationships for ERBB3 gene (see all 47)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 83.3 232 7514177 (4), 7929151 (4), 8058768 (4), 11189010 (3) (see all 99)
    pertuzumab 81.7 15 19737968 (6), 17627612 (3), 18632642 (2), 17547474 (1) (see all 5)
    hrgbeta1 81.6 3 12209601 (2)
    gefitinib 81.5 55 15731348 (7), 18803287 (5), 17638894 (4), 16818711 (3) (see all 20)
    trastuzumab 79.3 18 20103628 (5), 18625725 (2), 19276389 (1), 19934333 (1) (see all 12)
    lapatinib 77.3 6 16020981 (1), 18334972 (1), 14737100 (1), 15755991 (1)
    erlotinib 69.3 17 16928826 (7), 17457047 (5)
    cetuximab 69.1 8 19276677 (2), 18297114 (2), 15585383 (1), 16424038 (1) (see all 6)
    phosphatidylinositol 64.8 45 7929151 (5), 7535767 (4), 9886492 (2), 8732665 (2) (see all 22)
    ag 1478 57.2 3 18682844 (1), 10533979 (1)

    Search CenterWatch for drugs/clinical trials and news about ERBB3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ERBB3 gene (2 alternative transcripts): 
    NM_001005915.1  NM_001982.3  

    Unigene Cluster for ERBB3:

    V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
    Hs.118681  [show with all ESTs]
    Unigene Representative Sequence: NM_001982
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000549282 ENST00000549061 ENST00000267101(uc001sjh.3 uc009zoj.3 uc010sqb.2 uc010sqc.2 uc009zok.3 uc001sjk.3)
    ENST00000411731(uc001sjg.3) ENST00000550869 ENST00000551085 ENST00000546884
    ENST00000551242 ENST00000549672 ENST00000415288(uc001sjj.1) ENST00000549472
    ENST00000546748 ENST00000551176(uc001sji.3) ENST00000549205 ENST00000550828
    ENST00000550070 ENST00000549644 ENST00000553131
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ERBB3
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate ERBB3 (see all 57):
    hsa-miR-106a hsa-miR-301a hsa-miR-500a hsa-miR-766 hsa-miR-519a hsa-miR-877* hsa-miR-93 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidERBB3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ERBB3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ERBB3
    Clone
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    OriGene clones in human, mouse for ERBB3 (see all 16)
    OriGene ORF clones in mouse, rat for ERBB3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ERBB3 (NM_001005915)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERBB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERBB3
    Sirion Biotech Customized lentivirus for stable overexpression of ERBB3 
                         Customized lentivirus expression plasmids for stable overexpression of ERBB3 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ERBB3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ERBB3

    Additional mRNA sequence: 

    AF086028.1 AK124710.1 AK125028.1 AK291681.1 AK294719.1 AK295650.1 AK300909.1 BC002706.2 
    BC041579.1 BC082992.1 BT007226.1 M29366.1 M34309.1 S61953.1 U88357.1 U88358.1 
    U88359.1 U88360.1 

    20 DOTS entries:

    DT.98131702  DT.95179527  DT.100791868  DT.95102464  DT.101982408  DT.100700960  DT.213585  DT.100038754 
    DT.91963462  DT.75114482  DT.95184370  DT.86837952  DT.92440238  DT.101982406  DT.121128974  DT.121129014 
    DT.95082546  DT.121634328  DT.444493  DT.91823725 

    24/234 AceView cDNA sequences (see all 234):

    BF476702 BX479156 BQ218231 AI611284 AI201918 AU121609 NM_001982 F13163 
    BF477611 BP357593 AW006088 BM976983 CR621450 BU190632 BQ888885 BQ225650 
    BU168324 BF726040 BU194156 AW949549 AW375856 BU179810 BC002706 BQ877641 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ERBB3 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^ 17 ^
    SP1:                          -                 -                                                                                         -           -         
    SP2:                                                                                                                                      -           -         
    SP3:                                                                                                                                                            
    SP4:                          -                 -                                         -     -     -     -     -     -     -     -     -     -     -     -   
    SP5:                                                                                                                                                            

    ExUns: 18 ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29
    SP1:        -                             -           -                                                         
    SP2:        -           -     -     -     -     -     -                                                         
    SP3:                                      -           -                                                         
    SP4:  -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                     
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for ERBB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ERBB3 expression in normal human tissues (normalized intensities)      ERBB3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCGTAAAT
    ERBB3 Expression
    About this image


    ERBB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 5 entries
             Atrioventricular Valve Cells Atrioventricular Valves
             Cardiac progenitor cells (Sca1+)
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 4 entries
             Immature Schwann Cells Peripheral Nerve Domain
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Olfactory Bulb   
     
     Neural Crest (Gastrulation Derivatives)
             mesenchyme/trunk mesenchyme   
     
     Bone (Muscoskeletal System)
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   

    See ERBB3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ERBB3

    SOURCE GeneReport for Unigene cluster: Hs.118681

    UniProtKB/Swiss-Prot: ERBB3_HUMAN, P21860
    Tissue specificity: Epithelial tissues and brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including ERBB3 (see all 6): 
              Lung Cancer in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              Cancer Drug Targets in human mouse rat
              Multiple Sclerosis in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERBB3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ERBB3 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Erbb31 , 5 v-erb-b2 erythroblastic leukemia viral oncogene homolog more1, 5 86.97(n)1
    90.96(a)1
      10 (77.10 cM)5
    138671  NM_010153.11  NP_034283.11 
     1285675235 
    chicken
    (Gallus gallus)
    Aves ERBB31 v-erb-b2 erythroblastic leukemia viral oncogene homolog more 68.58(n)
    70.99(a)
      693245  NM_001044669.1  NP_001038134.1 
    lizard
    (Anolis carolinensis)
    Reptilia ERBB36
    v-erb-b2 erythroblastic leukemia viral oncogene ho...
    66(a)
    1 ↔ 1
    GL343198.1(3603873-3705750)
    zebrafish
    (Danio rerio)
    Actinopterygii erbb3b1 v-erb-b2 erythroblastic leukemia viral oncogene homolog more 58.3(n)
    57.55(a)
      544664  NM_001014826.1  NP_001014826.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Egfr3 eggshell pattern formation epidermal
    growth factor more
    39(a)     --


    ENSEMBL Gene Tree for ERBB3 (if available)
    TreeFam Gene Tree for ERBB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ERBB3 gene
    SYK2  TNK12  JAK32  JAK22  TNK22  TYK22  ERBB42  JAK12  
    PTK22  ERBB22  ZAP702  EGFR2  PTK2B2  
    15 SIMAP similar genes for ERBB3 using alignment to 10 protein entries:     ERBB3_HUMAN (see all proteins):
    c-erbB-3    EPHA4    ERBB4    FGFR1    EGFR    ERBB2
    HER-2    ABL1    EPHA2    tec    FGR    INSR
    DKFZp686M05208    MAP3K11    TXK

    ERBB3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/735 SNPs in ERBB3 are shown (see all 735)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0421034
    An ovarian mucinous carcinoma sample4--see VAR_0421032 V M mis40--------
    rs1513113581,2
    Cuntested156493973(+) TTTTAA/C/GGTCCA 2 S G mis10--------
    rs1478025941,2
    --56472042(+) GCCCAG/TCTAAT 2 -- us2k10--------
    rs1834990241,2
    --56472052(+) TTTTTA/GTATTT 2 -- us2k10--------
    rs1894518901,2
    --56472100(+) GTCTCA/GAACTC 2 -- us2k10--------
    rs1924880001,2
    --56472126(+) CTGCCC/TGCCTC 2 -- us2k10--------
    rs349388371,2
    C--56472279(+) GTCTC-/AAAAAA 2 -- us2k10--------
    rs1450070731,2
    --56472286(+) AAAAAA/CAAAAA 2 -- us2k10--------
    rs580348091,2
    C--56472293(+) AAAAA-/A/GGAAAA 2 -- us2k11NA 2
    rs764541111,2
    --56472294(+) AAAAAA/GAAAAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ERBB3 (56473641 - 56497291 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ERBB3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1499550CNV Insertion17803354
    nsv832427CNV Loss17160897
    esv275479CNV Gain+Loss21479260


    Human Gene Mutation Database (HGMD): ERBB3
    SABiosciences Cancer Mutation PCR Assays
    2 SABiosciences qBiomarker Copy Number PCR Arrays containing ERBB3:
    Oncogenes & Tumor Suppressor Genes 384HC
    Gastric Cancer
    SeqTarget long-range PCR primers for resequencing ERBB3
    DNA2.0 Custom Variant and Variant Library Synthesis for ERBB3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 190151   
    OMIM disorders: 607598  
    UniProtKB/Swiss-Prot: ERBB3_HUMAN, P21860
  • Lethal congenital contracture syndrome 2 (LCCS2) [MIM:607598]: A form of lethal congenital contracture
    syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme
    skeletal muscle atrophy, and congenital non-progressive joint contractures (arthrogryposis). The contractures can
    involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension
    limitations evident at birth. LCCS2 patients manifest craniofacial/ocular findings, lack of hydrops, multiple
    pterygia, and fractures, as well as a normal duration of pregnancy and a unique feature of a markedly distended
    urinary bladder (neurogenic bladder defect). The phenotype suggests a spinal cord neuropathic etiology. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 20/80 diseases for ERBB3 (see all 80):    About MalaCards
    lethal congenital contracture syndrome 2    lethal congenital contractural syndrome 2    gestational trophoblastic tumor    congenital contractures
    carotid body tumor    melanoma of soft part    clear cell sarcoma    verrucous carcinoma
    charcot-marie-tooth disease type 1a    childhood medulloblastoma    charcot-marie-tooth disease type 1    adenoiditis
    medulloblastoma    pancreatic cancer    endometrial stromal sarcoma    ductal carcinoma in situ
    pterygium    estrogen-receptor positive breast cancer    neuroma    adenoid cystic carcinoma

    3 diseases from the University of Copenhagen DISEASES database for ERBB3:
    Breast cancer     Carcinoma     Lung cancer

    ERBB3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/67 Novoseek inferred disease relationships for ERBB3 gene (see all 67)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 72 111 17266042 (4), 18425425 (4), 18632642 (4), 15704104 (3) (see all 61)
    breast carcinoma 64.8 30 15770691 (3), 9823984 (2), 8732665 (2), 10473632 (2) (see all 21)
    tumors 61.5 169 18507044 (5), 18398842 (4), 19401448 (4), 11789762 (3) (see all 99)
    cancer 58.8 98 20215504 (5), 20179223 (4), 18404164 (3), 9712416 (3) (see all 57)
    viral leukemia 58.3 3 15150091 (1), 17275115 (1), 12021921 (1)
    nsclc 56.6 37 15731348 (6), 16843264 (3), 19648825 (2), 16288303 (2) (see all 19)
    carcinoma 47.2 55 9494565 (4), 7673253 (3), 11135221 (3), 8683379 (3) (see all 29)
    carcinoma non-small cell lung 43.6 3 9127320 (3)
    cancer lung 41.9 19 17631905 (3), 14739033 (2), 17627612 (2), 20351256 (1) (see all 13)
    metastasis 41.1 43 18398842 (5), 18172732 (3), 18698037 (3), 12888923 (2) (see all 24)

    Genetic Association Database (GAD): ERBB3
    Human Genome Epidemiology (HuGE) Navigator: ERBB3 (31 documents)
    Tumor Gene Database (TGDB): ERBB3

    Export disorders for ERBB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ERBB3 gene, integrated from 9 sources (see all 741) (see top 10):
    (articles sorted by number of sources associating them with ERBB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase. (PubMed id 7685162)1, 2, 9 Katoh M.... Terada M. (1993)
    2. Schizophrenia is not associated with the functional candidate gene ERBB3: results from a case-control study. (PubMed id 16958035)1, 4, 9 Kanazawa T....Tsuang M.T. (2007)
    3. No association between the ERBB3 gene and schizophrenia in a Japanese population. (PubMed id 17275115)1, 4, 9 Watanabe Y....Someya T. (2007)
    4. ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation. (PubMed id 20351256)1, 2, 9 Shi F....Lemmon M.A. (2010)
    5. Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3. (PubMed id 9516479)1, 2, 9 Fiddes R.J....Daly R.J. (1998)
    6. Neuroglycan C, a novel member of the neuregulin family. (PubMed id 15358134)1, 2, 9 Kinugasa Y....Higashiyama S. (2004)
    7. Genome-wide association analysis of autoantibody posit ivity in type 1 diabetes cases. (PubMed id 21829393)1, 4 Plagnol V....Todd J.A. (2011)
    8. Somatic mutations in epidermal growth factor receptor signaling pathway genes in non-small cell lung cancers. (PubMed id 20881644)1, 4 Lee S.Y....Park J.Y. (2010)
    9. A targeted association study in systemic lupus erythe matosus identifies multiple susceptibility alleles. (PubMed id 20962850)1, 4 Budarf M.L....Rioux J.D. (2010)
    10. Genome-wide searching of rare genetic variants in WTC CC data. (PubMed id 20549515)1, 4 Feng T. and Zhu X. (2010)
    11. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    12. A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk. (PubMed id 20446891)1, 4 Andersson U....Melin B. (2010)
    13. Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis. (PubMed id 20647273)1, 4 Hinks A....Thomson W. (2010)
    14. [Association of the polymorphisms of the ERBB3 and SH 2B3 genes with type 1 diabetes] (PubMed id 20586186)1, 4 Nikitin A.G....Nosikov V.V. (2010)
    15. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    16. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    17. Genetic susceptibility to type 2 diabetes is associat ed with reduced prostate cancer risk. (PubMed id 20203524)1, 4 Pierce B.L. and Ahsan H. (2010)
    18. Association of Type 1 Diabetes with Two Loci on 12q13 and 16p13 and the Influence Coexisting Thyroid Autoimmunity in Japanese. (PubMed id 18940880)1, 4 Awata T....Katayama S. (2009)
    19. Case-control study of association between the functio nal candidate gene ERBB3 and schizophrenia in Caucasian population. (PubMed id 19995212)1, 4 Li D....He L. (2009)
    20. Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis. (PubMed id 19951419)1, 4 Carr E.J....Smith K.G. (2009)
    21. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. (PubMed id 19430480)1, 4 Barrett J.C....Rich S.S. (2009)
    22. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    23. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (2009)
    24. A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. (PubMed id 18198356)1, 4 Hakonarson H....Polychronakos C. (2008)
    25. Shared and distinct genetic variants in type 1 diabetes and celiac disease. (PubMed id 19073967)1, 4 Smyth D.J....Todd J.A. (2008)
    26. Polymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency. (PubMed id 18593762)1, 4 Skinningsrud B....Undlien D.E. (2008)
    27. Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. (PubMed id 18978792)1, 4 Cooper J.D....Todd J.A. (2008)
    28. Lethal congenital contractural syndrome type 2 (LCCS2) is caused by a mutation in ERBB3 (Her3), a modulator of the phosphatidylinositol-3- kinase/Akt pathway. (PubMed id 17701904)1, 2 Narkis G.... Birk O.S. (2007)
    29. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PubMed id 17554300)1, 4  . (2007)
    30. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. (PubMed id 17554260)1, 4 Todd J.A.... Clayton D.G. (2007)
    31. An extended association screen in multiple sclerosis using 202 microsatellite markers targeting apoptosis-related genes does not reveal new predisposing factors. (PubMed id 16143043)1, 4 Godde R....Epplen J.T. (2005)
    32. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    33. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    34. Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein. (PubMed id 12939402)1, 2 Li Y....Kufe D. (2003)
    35. Structure of the extracellular region of HER3 reveals an interdomain tether. (PubMed id 12154198)1, 2 Cho H.S. and Leahy D.J. (2002)
    36. Regulation of the ErbB3 binding protein Ebp1 by protein kinase C. (PubMed id 11325528)1, 2 Lessor T.J. and Hamburger A.W. (2001)
    37. Molecular cloning and expression of an additional epidermal growth factor receptor-related gene. (PubMed id 2164210)1, 2 Plowman G.D.... Shoyab M. (1990)
    38. Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. (PubMed id 2687875)1, 2 Kraus M.H.... Aaronson S.A. (1989)
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    179. Endocrine resistance associated with activated ErbB s ystem in breast cancer cells is reversed by inhibiting MAPK or PI3K/Akt signali ng pathways. (PubMed id 19609946)1 Ghayad S.E....Cohen P.A. (2010)
    180. Post-transcriptional mechanisms contribute to the sup pression of the ErbB3 negative regulator protein Nrdp1 in mammary tumors. (PubMed id 20628057)1 Ingalla E.Q....Carraway K.L. (2010)
    181. Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1 /ErbB signaling. (PubMed id 20682778)1 Ieguchi K....Takada Y. (2010)
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    183. Significance of integrin I+vI^5 and erbB3 in enhanced c ell migration and liver metastasis of colon carcinomas stimulated by hepatocyte -derived heregulin. (PubMed id 20626753)1 Yoshioka T....Enomoto K. (2010)
    184. Sclerostin-erbB-3 interactions: modulation of erbB-3 activity by sclerostin. (PubMed id 20951118)1 Craig T.A. and Kumar R. (2010)
    185. An activated ErbB3/NRG1 autocrine loop supports in vi vo proliferation in ovarian cancer cells. (PubMed id 20227043)1 Sheng Q....Liu J.F. (2010)
    186. Nrdp1-mediated regulation of ErbB3 expression by the androgen receptor in androgen-dependent but not castrate-resistant prostate can cer cells. (PubMed id 20587519)1 Chen L....Ghosh P.M. (2010)
    187. Early response to ErbB2 over-expression in polarized Caco-2 cells involves partial segregation from ErbB3 by relocalization to the a pical surface and initiation of survival signaling. (PubMed id 20589763)1 Pfister A.B....Ramsauer V.P. (2010)
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    189. HER3 and downstream pathways are involved in coloniza tion of brain metastases from breast cancer. (PubMed id 20604919)1 Da Silva L....Lakhani S.R. (2010)
    190. Genetically dependent ERBB3 expression modulates anti gen presenting cell function and type 1 diabetes risk. (PubMed id 20668683)1 Wang H....She J.X. (2010)
    191. H1047R phosphatidylinositol 3-kinase mutant enhances HER2-mediated transformation by heregulin production and activation of HER3. (PubMed id 20581867)1 Chakrabarty A....Arteaga C.L. (2010)
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    194. ErbB3 expression promotes tumorigenesis in pancreatic adenocarcinoma. (PubMed id 20647770)1 Liles J.S....Frolov A. (2010)
    195. Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity. (PubMed id 19060928)1 Scaltriti M....Baselga J. (2009)
    196. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
    197. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
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    199. EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance. (PubMed id 18852121)1 Zhang Y....Hamburger A.W. (2008)
    200. Higher-order association states of cellular ERBB3 probed with photo-cross-linkable aptamers. (PubMed id 18942860)1 Park E....Landgraf R. (2008)
    201. A critical role for HSP90 in cancer cell invasion involves interaction with the extracellular domain of HER-2. (PubMed id 18056992)1 Sidera K....Patsavoudi E. (2008)
    202. Evaluation of type 1 growth factor receptor family expression in benign and malignant thyroid lesions. (PubMed id 18424286)1 Wiseman S.M....Jones S.J. (2008)
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    204. Soluble ErbB3 levels in bone marrow and plasma of men with prostate cancer. (PubMed id 18559590)1 Lin S.H....Logothetis C.J. (2008)
    205. FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival. (PubMed id 18381441)1 Kunii K....Lutterbach B. (2008)
    206. Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas. (PubMed id 18231572)1 Yu L....Dixon D. (2008)
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    209. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. (PubMed id 17463250)1 Engelman J.A....Janne P.A. (2007)
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    218. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
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    220. The mucin Muc4 potentiates neuregulin signaling by increasing the cell-surface populations of ErbB2 and ErbB3. (PubMed id 16690615)1 Funes M....Sweeney C. (2006)
    221. Tyrosine phosphorylation of PYK2 mediates heregulin-induced glioma invasion: novel heregulin/HER3-stimulated signaling pathway in glioma. (PubMed id 15499613)1 van der Horst E.H....Ullrich A. (2005)
    222. Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling. (PubMed id 15504738)1 Le X.F....Bast R.C. (2005)
    223. Selective hormone-dependent repression of estrogen receptor beta by a p38-activated ErbB2/ErbB3 pathway. (PubMed id 15862947)1 St-Laurent V....Tremblay A. (2005)
    224. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    225. Expression of mutant human epidermal receptor 3 attenuates lung fibrosis and improves survival in mice. (PubMed id 15731393)1 Nethery D.E....Kern J.A. (2005)
    226. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
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    228. Specificity and heregulin regulation of Ebp1 (ErbB3 binding protein 1) mediated repression of androgen receptor signalling. (PubMed id 15583694)1 Zhang Y. and Hamburger A.W. (2005)
    229. Phosphotyrosine interactome of the ErbB-receptor kinase family. (PubMed id 16729043)1 Schulze W.X....Mann M. (2005)
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    231. ErbB3/HER3 does not homodimerize upon neuregulin binding at the cell surface. (PubMed id 15225657)1 Berger M.B....Lemmon M.A. (2004)
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    233. Homozygosity mapping of lethal congenital contractural syndrome type 2 (LCCS2) to a 6 cM interval on chromosome 12q13. (PubMed id 15378541)1 Narkis G....Birk O.S. (2004)
    234. Role of proneuregulin 1 cleavage and human epidermal growth factor receptor activation in hypertonic aquaporin induction. (PubMed id 15498868)1 Herrlich A....King L.S. (2004)
    235. Tetraspanin CD82 regulates compartmentalisation and ligand-induced dimerization of EGFR. (PubMed id 14576349)1 Odintsova E....Berditchevski F. (2003)
    236. Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival. (PubMed id 12824184)1 Li B.S....Pant H.C. (2003)
    237. Segregation of receptor and ligand regulates activation of epithelial growth factor receptor. (PubMed id 12646923)1 Vermeer P.D....Welsh M.J. (2003)
    238. Proliferation-differentiation relationships in the expression of heparin-binding epidermal growth factor-related factors and erbB receptors by normal and psoriatic human keratinocytes. (PubMed id 12768307)1 Piepkorn M....Cook P. (2003)
    239. Identification of novel ErbB3-interacting factors using the split-ubiquitin membrane yeast two-hybrid system. (PubMed id 12840049)1 Thaminy S....Stagljar I. (2003)
    240. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    241. Epidermal growth factor contains both positive and negative determinants for interaction with ErbB-2/ErbB-3 heterodimers. (PubMed id 11914075)1 Stortelers C....van Zoelen E.J. (2002)
    242. An unexpected biochemical and functional interaction between gp130 and the EGF receptor family in breast cancer cells. (PubMed id 11821958)1 Grant S.L....Begley C.G. (2002)
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    246. Neuregulin-induced association of Sos Ras exchange protein with HER2(erbB2)/HER3(erbB3) receptor complexes in Schwann cells through a specific Grb2-HER2(erbB2) interaction. (PubMed id 11173924)1 Goodearl A....Vartanian T. (2001)
    247. Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland. (PubMed id 11278868)1 Schroeder J.A....Gendler S.J. (2001)
    248. Identification and characterization of the potential promoter regions of 1031 kinds of human genes. (PubMed id 11337467)1 Suzuki Y....Sugano S. (2001)
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    250. The phosphatidylinositol 3'-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells. (PubMed id 10383151)1 Lin J....Freeman M.R. (1999)
    251. Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity. (PubMed id 10572067)1 Fernandes A.M....Gerwin B.I. (1999)
    252. Isolation and characterization of four alternate c-erbB3 transcripts expressed in ovarian carcinoma-derived cell lines and normal human tissues. (PubMed id 9681822)1 Lee H. and Maihle N.J. (1998)
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    259. Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor. (PubMed id 7689552)1 Culouscou J.-M.... Shoyab M. (1993)
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    261. Increased expression of erbB3 in colorectal cancer is associated with concomitant increase in the level of erbB2. (PubMed id 9712416)9 Maurer C.A....Buchler M.W. (1998)
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    264. The outcome of heregulin-induced activation of ovarian cancer cells depends on the relative levels of HER-2 and HER-3 expression. (PubMed id 10589783)9 Xu F....Bast R.C. (1999)
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    268. Overexpression of p53, EGFR, c-erbB2 and c-erbB3 in endometrioid carcinoma of the ovary. (PubMed id 11324501)9 Leng J....Guo L. (1997)
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    273. HER-3 in colorectal tumourigenesis: from mRNA levels through protein status to clinicopathologic relationships. (PubMed id 17920261)9 Grivas P.D....Kalofonos H. (2007)
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    281. Cloning of the rat ErbB3 cDNA and characterization of the recombinant protein. (PubMed id 8522190)9 Hellyer N.J....Koland J.G. (1995)
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    470. HER3 comes of age: new insights into its functions an d role in signaling, tumor biology, and cancer therapy. (PubMed id 20179223)9 Campbell M.R....Moasser M.M. (2010)
    471. Somatic mutations of EGFR, ERBB2, ERBB3 and ERBB4 in juxtamembrane activating domains are rare in non-small cell lung cancers. (PubMed id 20041876)9 Park S.W....Lee S.H. (2010)
    472. Suppression of HER2/HER3-mediated growth of breast ca ncer cells with combinations of GDC-0941 PI3K inhibitor, trastuzumab, and pertu zumab. (PubMed id 19509167)9 Yao E....Hoeflich K.P. (2009)
    473. Quantification of ErbB3 receptor density on human breast cancer cells, using a stable radio-labeled mutant of NRG1beta. (PubMed id 19026613)9 van der Woning S.P. and van Zoelen E.J. (2009)
    474. Inhibition of functional HER family members increases the sensitivity to docetaxel in human ovarian cancer cell lines. (PubMed id 19369859)9 Bijman M.N....Boven E. (2009)
    475. Gene expression profiling identifies activated growth factor signaling in poor prognosis (Luminal-B) estrogen receptor positive brea st cancer. (PubMed id 19552798)9 Loi S....McArthur G.A. (2009)
    476. Fluorescence recovery after photobleaching and photoconversion in multiple arbitrary regions of interest using a programmable array microscope. (PubMed id 19208387)9 Hagen G.M....Jovin T.M. (2009)
    477. RGS16 inhibits breast cancer cell growth by mitigatin g phosphatidylinositol 3-kinase signaling. (PubMed id 19509421)9 Liang G....Druey K.M. (2009)
    478. ErbB receptor tyrosine kinases contribute to proliferation of malignant melanoma cells: inhibition by gefitinib (ZD1839). (PubMed id 19434003)9 Djerf E.A....Walz T.M. (2009)
    479. ErbB2 and ErbB3 regulate amputation-induced proliferation and migration during vertebrate regeneration. (PubMed id 19133254)9 Rojas-MuA+oz A....IzpisA_a Belmonte J.C. (2009)
    480. Quantitative multiplexed analysis of ErbB family coexpression for primary breast cancer prognosis in a large retrospective cohort. (PubMed id 19330842)9 Giltnane J.M....Rimm D.L. (2009)
    481. Insulin-like growth factor-1 receptor inhibition indu ces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT si gnaling pathway: rational basis for cotargeting insulin-like growth factor-1 re ceptor and epidermal growth factor receptor in hepatocellular carcinoma. (PubMed id 19706799)9 Desbois-Mouthon C....Rosmorduc O. (2009)
    482. Therapeutically targeting ErbB3: a key node in ligand -induced activation of the ErbB receptor-PI3K axis. (PubMed id 19567914)9 Schoeberl B....Nielsen U.B. (2009)
    483. Molecular pharmacodynamics of PM02734 (elisidepsin) a s single agent and in combination with erlotinib; synergistic activity in human non-small cell lung cancer cell lines and xenograft models. (PubMed id 19346126)9 Ling Y.H....Zou Y. (2009)
    484. Strongly enhanced antitumor activity of trastuzumab a nd pertuzumab combination treatment on HER2-positive human xenograft tumor mode ls. (PubMed id 19934333)9 Scheuer W....Hasmann M. (2009)
    485. Trastuzumab-induced HER reprogramming in 'resist ant' breast carcinoma cells. (PubMed id 19276389)9 Narayan M....Maihle N.J. (2009)
    486. MP470, a novel receptor tyrosine kinase inhibitor, in combination with Erlotinib inhibits the HER family/PI3K/Akt pathway and tumor growth in prostate cancer. (PubMed id 19432987)9 Qi W....Mahadevan D. (2009)
    487. HER1-4 protein concentrations in normal breast tissue from breast cancer patients are expressed by the same profile as in the malign ant tissue. (PubMed id 19548848)9 Olsen D.A....Brandslund I. (2009)
    488. Role of the C-terminal linear region of EGF-like growth factors in ErbB specificity. (PubMed id 19384683)9 van der Woning S.P....van Zoelen E.J. (2009)
    489. Neuregulin-1 signaling in brain endothelial cells. (PubMed id 18728681)9 Lok J....Lo E.H. (2009)
    490. Identification of biomarkers in human head and neck t umor cell lines that predict for in vitro sensitivity to gefitinib. (PubMed id 20443891)9 Hickinson D.M....Speake G. (2009)
    491. Tumor-specific apoptosis caused by deletion of the ER BB3 pseudo-kinase in mouse intestinal epithelium. (PubMed id 19690388)9 Lee D....Threadgill D.W. (2009)
    492. Internalization and intracellular sorting of the EGF receptor: a model for understanding the mechanisms of receptor trafficking. (PubMed id 19759283)9 Madshus I.H. and Stang E. (2009)
    493. Silencing of ErbB3/ErbB2 signaling by immunoglobulin- like Necl-2. (PubMed id 19561085)9 Kawano S....Takai Y. (2009)
    494. Nuclear translocation of the epidermal growth factor receptor family membrane tyrosine kinase receptors. (PubMed id 19861462)9 Wang S.C. and Hung M.C. (2009)
    495. Suppression of the kinase activity of receptor tyrosine kinases by anthocyanin-rich mixtures extracted from bilberries and grapes. (PubMed id 19323506)9 Teller N....Marko D. (2009)
    496. Rational optimization of a bispecific ligand trap targeting EGF receptor family ligands. (PubMed id 19048033)9 Jin P....Shepard H.M. (2009)
    497. The role of the EGFR signaling in tumor microenvironment. (PubMed id 17894407)9 De Luca A....Normanno N. (2008)
    498. EGFR mutations and HER2/3 protein expression and clinical outcome in Chinese advanced non-small cell lung cancer patients treated with gefitinib. (PubMed id 19020901)9 Xu J.M....Paradiso A. (2008)
    499. Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations. (PubMed id 19010923)9 Yano S....Sone S. (2008)
    500. Real-time reverse-transcription PCR to quantify a panel of 19 genes in breast cancer: relationships with sentinel lymph node invasion. (PubMed id 18409145)9 Revillion F....Peyrat J.P. (2008)
    501. HER2 oncogenic function escapes EGFR tyrosine kinase inhibitors via activation of alternative HER receptors in breast cancer cells. (PubMed id 18682844)9 Kong A....Larijani B. (2008)
    502. Kinase switching in mesenchymal-like non-small cell lung cancer lines contributes to EGFR inhibitor resistance through pathway redundancy. (PubMed id 18696232)9 Thomson S....Haley J.D. (2008)
    503. Cross-talk between the ErbB/HER family and the type I insulin-like growth factor receptor signaling pathway in breast cancer. (PubMed id 19034632)9 Jin Q. and Esteva F.J. (2008)
    504. Ebp1 expression in benign and malignant prostate. (PubMed id 19025630)9 Gannon P.O....Saad F. (2008)
    505. Activity of lapatinib a novel HER2 and EGFR dual kinase inhibitor in human endometrial cancer cells. (PubMed id 18334972)9 Konecny G.E....Podratz K.C. (2008)
    506. Macrophage inhibitory cytokine-1 activates AKT and ERK-1/2 via the transactivation of ErbB2 in human breast and gastric cancer cells. (PubMed id 18258606)9 Kim K.K....Lee J.H. (2008)
    507. Human epidermal growth factor receptor (HER-1:HER-3) Fc-mediated heterodimer has broad antiproliferative activity in vitro and in human tumor xenografts. (PubMed id 18852126)9 Sarup J....Shepard H.M. (2008)
    508. Breast cancer cells with acquired resistance to the E GFR tyrosine kinase inhibitor gefitinib show persistent activation of MAPK sign aling. (PubMed id 18060492)9 Normanno N....Menard S. (2008)
    509. System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties. (PubMed id 18721752)9 Kaushansky A....MacBeath G. (2008)
    510. Resveratrol inhibits heregulin-beta1-mediated matrix metalloproteinase-9 expression and cell invasion in human breast cancer cells. (PubMed id 17651959)9 Tang F.Y....Sun Y.C. (2008)
    511. Stochastic simulations of ErbB homo and heterodimerisation: potential impacts of receptor conformational state and spatial segregation. (PubMed id 19045821)9 Hsieh M.Y....Edwards J.S. (2008)
    512. Disturbed structural connectivity in schizophrenia primary factor in pathology or epiphenomenon? (PubMed id 17485733)9 Konrad A. and Winterer G. (2008)
    513. Clinical implications of the ErbB/epidermal growth factor (EGF) receptor family and its ligands in ovarian cancer. (PubMed id 18291115)9 Lafky J.M....Maihle N.J. (2008)
    514. Expression of the epidermal growth factor system in endometrial cancer. (PubMed id 19051810)9 Adonakis G....Kourounis G. (2008)
    515. Targeting ErbB2 and ErbB3 with a bispecific single-chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro. (PubMed id 18841159)9 Robinson M.K....Adams G.P. (2008)
    516. Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R. (PubMed id 17918158)9 Patel B.B....Majumdar A.P. (2008)
    517. Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex. (PubMed id 18470533)9 Colantuoni C....Kleinman J.E. (2008)
    518. Epidermal growth factor receptor tyrosine phosphorylation and signaling controlled by a nuclear receptor coactivator, amplified in breast cancer 1. (PubMed id 17671194)9 Lahusen T....Riegel A.T. (2007)
    519. Inhibition of Hsp90: a multitarget approach to radiosensitization. (PubMed id 17671112)9 Camphausen K. and Tofilon P.J. (2007)
    520. Amplified in breast cancer 1 in human epidermal growth factor receptor - positive tumors of tamoxifen-treated breast cancer patients. (PubMed id 17332282)9 Kirkegaard T....Bartlett J.M. (2007)
    521. Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling. (PubMed id 17761519)9 Wang L....Robins A.J. (2007)
    522. Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling. (PubMed id 17539658)9 Pan M.H....Chen W.J. (2007)
    523. RGS4 is not a susceptibility gene for schizophrenia in Japanese: association study in a large case-control population. (PubMed id 17092693)9 Ishiguro H....Arinami T. (2007)
    524. A novel approach for identification of tumor-associated antigens expressed on the surface of tumor cells. (PubMed id 17163417)9 Di Cristina M....Gargano N. (2007)
    525. Expression of the epidermal growth factor system in endometrioid endometrial cancer. (PubMed id 16962163)9 Ejskjaer K....Mogensen O. (2007)
    526. HER2-positive breast cancer: current and future treatment strategies. (PubMed id 17547474)9 Engel R.H. and Kaklamani V.G. (2007)
    527. Growth stimulation of non-small cell lung cancer cell lines by antibody against epidermal growth factor receptor promoting formation of ErbB2/ErbB3 heterodimers. (PubMed id 17426253)9 Maegawa M....Ito F. (2007)
    528. Abundance and localization of skeletal muscle-related erbB2 may stimulate tumour growth during initial stages of oral oncogenesis. (PubMed id 17627089)9 Vairaktaris E....Patsouris E. (2007)
    529. Expression of ErbB receptor proteins and TGF-alpha during diethylnitrosamine-induced hepatocarcinogenesis in the rat liver. (PubMed id 17380077)9 Lee T.Y....Han S.Y. (2007)
    530. The alpha6beta4 integrin can regulate ErbB-3 expression: implications for alpha6beta4 signaling and function. (PubMed id 17308105)9 Folgiero V....Mercurio A.M. (2007)
    531. Nucleic acid aptamers for targeting of shRNA-based ca ncer therapeutics. (PubMed id 19707307)9 Vorhies J.S. and Nemunaitis J.J. (2007)
    532. SRC-family kinases are activated in non-small cell lu ng cancer and promote the survival of epidermal growth factor receptor-dependen t cell lines. (PubMed id 17200208)9 Zhang J....Kurie J.M. (2007)
    533. Anaplastic thyroid carcinoma: expression profile of targets for therapy offers new insights for disease treatment. (PubMed id 17115102)9 Wiseman S.M....Gilks B. (2007)
    534. [Relation between c-erbB1, c-erbB2, MAPK expression a nd resistance to tamoxifen in breast cancer cells in vitro] (PubMed id 17416003)9 Zhang Q.Y....Kang X.M. (2006)
    535. Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers. (PubMed id 16231326)9 Shigematsu H. and Gazdar A.F. (2006)
    536. Constitutive neuregulin-1/ErbB signaling contributes to human vestibular schwannoma proliferation. (PubMed id 16432850)9 Hansen M.R....Green S.H. (2006)
    537. Compensatory ErbB3/c-Src signaling enhances carcinoma cell survival to ionizing radiation. (PubMed id 16267617)9 Contessa J.N....Schmidt-Ullrich R.K. (2006)
    538. A high-throughput migration assay reveals HER2-mediated cell migration arising from increased directional persistence. (PubMed id 16782798)9 Kumar N....Lauffenburger D.A. (2006)
    539. Targeting EGFR and HER-2 receptor tyrosine kinases for cancer drug discovery and development. (PubMed id 16788977)9 Kamath S. and Buolamwini J.K. (2006)
    540. Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs. (PubMed id 17189395)9 Ono M. and Kuwano M. (2006)
    541. Somatic mutations of the ERBB4 kinase domain in human cancers. (PubMed id 16187281)9 Soung Y.H....Lee S.H. (2006)
    542. Mutation of the PI3' kinase gene in a human colon carcinoma cell line, HCC2998. (PubMed id 16848681)9 Shi B.H....Fukui Y. (2006)
    543. Establishment and expression profiling of new lung cancer cell lines from Chinese smokers and lifetime never-smokers. (PubMed id 17409975)9 Lam D.C....Wong M.P. (2006)
    544. Epidermal growth factor receptor (EGFR) targeted therapies in non-small cell lung cancer (NSCLC). (PubMed id 18393776)9 Metro G....Cappuzzo F. (2006)
    545. Expression of the ErbB4 receptor causes reversal regulation of PP2A in the Shc signal transduction pathway in human cancer cells. (PubMed id 16477370)9 Yumoto N....Hatakeyama M. (2006)
    546. Expression of epidermal growth factors and their receptors in the bronchial epithelium of subjects with chronic obstructive pulmonary disease. (PubMed id 16393673)9 de Boer W.I....Hiemstra P.S. (2006)
    547. Antitumor activity of epidermal growth factor receptor-related protein is mediated by inactivation of ErbB receptors and nuclear factor-kappaB in pancreatic cancer. (PubMed id 16424038)9 Zhang Y....Sarkar F.H. (2006)
    548. Epidermal growth factor receptor mutation in lung cancer are linked to bronchioloalveolar differentiation. (PubMed id 17001163)9 Blons H....Danel C. (2006)
    549. Mechanisms of curcumin- and EGF-receptor related protein (ERRP)-dependent growth inhibition of colon cancer cells. (PubMed id 17044774)9 Reddy S....Majumdar A.P. (2006)
    550. Computational modelling of ErbB family phosphorylation dynamics in response to transforming growth factor alpha and heregulin indicates spatial compartmentation of phosphatase activity. (PubMed id 16983832)9 Hendriks B.S....de Graaf D. (2006)
    551. HER-2 and NF-kappaB as the targets for therapy-resistant breast cancer. (PubMed id 17201139)9 Ahmed K.M....Li J.J. (2006)
    552. Neuregulin growth factors and their ErbB receptors form a potential signaling network for schwannoma tumorigenesis. (PubMed id 16462207)9 Stonecypher M.S....Carroll S.L. (2006)
    553. Comprehensive copy number profiles of breast cancer cell model genomes. (PubMed id 16417655)9 Shadeo A. and Lam W.L. (2006)
    554. ErbB3-dependent motility and intravasation in breast cancer metastasis. (PubMed id 16452197)9 Xue C....Segall J.E. (2006)
    555. Isoliquiritigenin (ISL) inhibits ErbB3 signaling in prostate cancer cells. (PubMed id 17473376)9 Jung J.I....Park J.H. (2006)
    556. Identification of metastasis-associated receptor tyrosine kinases in non-small cell lung cancer. (PubMed id 15753374)9 Muller-Tidow C....Serve H. (2005)
    557. HER2 overexpression increases sensitivity to gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, through inhibition of HER2/HER3 heterodimer formation in lung cancer cells. (PubMed id 15899817)9 Hirata A....Ono M. (2005)
    558. EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells. (PubMed id 16053920)9 Shimizu M....Weinstein I.B. (2005)
    559. Herceptin-induced inhibition of ErbB2 signaling involves reduced phosphorylation of Akt but not endocytic down-regulation of ErbB2. (PubMed id 15800944)9 Longva K.E....Madshus I.H. (2005)
    560. EGFR and Her-2 regulate the constitutive activation of NF-kappaB in PC-3 prostate cancer cells. (PubMed id 15880609)9 Le Page C....Saad F. (2005)
    561. Role of HER2/HER3 co-receptor in breast carcinogenesis. (PubMed id 16556064)9 Way T.D. and Lin J.K. (2005)
    562. Neuregulins rescue PC12-ErbB-4 cells from cell death induced by beta-amyloid peptide: involvement of PI3K and PKC. (PubMed id 15968086)9 Di Segni A....Pinkas-Kramarski R. (2005)
    563. Cooperative cell-growth inhibition by combination treatment with ZD1839 (Iressa) and trastuzumab (Herceptin) in non-small-cell lung cancer. (PubMed id 16253759)9 Nakamura H....Shirouzu K. (2005)
    564. Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer. (PubMed id 15665299)9 Amann J....Carbone D.P. (2005)
    565. EGFR kinase possesses a broad specificity for ErbB phosphorylation sites, and ligand increases catalytic-centre activity without affecting substrate binding affinity. (PubMed id 16122376)9 Fan Y.X....Johnson G.R. (2005)
    566. Therapeutic targeting of multiple signaling pathways in malignant pleural mesothelioma. (PubMed id 16020981)9 Mukohara T....Janne P.A. (2005)
    567. The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand. (PubMed id 16203964)9 Bouyain S.... Leahy D.J. (2005)
    568. Antitumor activity of rapamycin in a transgenic mouse model of ErbB2-dependent human breast cancer. (PubMed id 15958580)9 Liu M....Abraham R.T. (2005)
    569. Multicenter, randomized phase II trial of oral CI-1033 for previously treated advanced ovarian cancer. (PubMed id 16110019)9 Campos S....Hirte H. (2005)
    570. Genistein inhibits insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells: a possible mechanism of the growth inhibitory effect of Genistein. (PubMed id 16379552)9 Kim E.J....Park J.H. (2005)
    571. Absence of HER4 expression predicts recurrence of ductal carcinoma in situ of the breast. (PubMed id 15788662)9 Barnes N.L....Bundred N.J. (2005)
    572. Activation of ErbB2 by overexpression or by transmembrane neuregulin results in differential signaling and sensitivity to herceptin. (PubMed id 16061662)9 Yuste L....Pandiella A. (2005)
    573. The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts. (PubMed id 16170026)9 Ihle N.T....Powis G. (2005)
    574. H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent. (PubMed id 15713896)9 CarA^n R.W....Dent P. (2005)
    575. ErbB2 overexpression in mammary cells upregulates VEGF through the core promoter. (PubMed id 15582599)9 Loureiro R.M....D'Amore P.A. (2005)
    576. Proliferation of human neuroblastomas mediated by the epidermal growth factor receptor. (PubMed id 16267010)9 Ho R....Brodeur G.M. (2005)
    577. Listeria monocytogenes produces a pro-invasive factor that signals via ErbB2/ErbB3 heterodimers. (PubMed id 15480783)9 Oliveira M.J....Leroy A. (2005)
    578. Differential responses to doxorubicin-induced phosphorylation and activation of Akt in human breast cancer cells. (PubMed id 16168102)9 Li X....Fan Z. (2005)
    579. Heregulin-induced activation of HER2 and HER3 increases androgen receptor transactivation and CWR-R1 human recurrent prostate cancer cell growth. (PubMed id 15755991)9 Gregory C.W....Earp H.S. (2005)
    580. Neuregulin-1 enhances survival of human astrocytic glioma cells. (PubMed id 15812817)9 Ritch P.S....Sontheimer H. (2005)
    581. Emerging treatments in oncology: focus on tyrosine kinase (erbB) receptor inhibitors. (PubMed id 14965154)9 Hamid O. (2004)
    582. The HER-2-targeting antibodies trastuzumab and pertuz umab synergistically inhibit the survival of breast cancer cells. (PubMed id 15059883)9 Nahta R....Esteva F.J. (2004)
    583. Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3. (PubMed id 15150091)9 Schaefer K.L....Poremba C. (2004)
    584. Blockade of epidermal growth factor- or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects. (PubMed id 15059917)9 Jackson J.G....Brattain M.G. (2004)
    585. Characterization of a novel cell line established from a patient with Herceptin-resistant breast cancer. (PubMed id 15634652)9 Tanner M....Isola J. (2004)
    586. Mechanisms of resistance to Erbitux (anti-epidermal growth factor receptor) combination therapy in pancreatic adenocarcinoma cells. (PubMed id 15585383)9 Arnoletti J.P....Vickers S.M. (2004)
    587. Thymic myoid cells express high levels of muscle genes. (PubMed id 14975590)9 Mesnard-Rouiller L....Berrih-Aknin S. (2004)
    588. Outcome and human epidermal growth factor receptor (HER) 1-4 status in invasive breast carcinomas with proliferation indices evaluated by bromodeoxyuridine labelling. (PubMed id 15084248)9 Tovey S.M....Cooke T.G. (2004)
    589. Role of HER receptors family in development and differentiation. (PubMed id 15254961)9 Casalini P....MAcnard S. (2004)
    590. Quantum dot ligands provide new insights into erbB/HER receptor-mediated signal transduction. (PubMed id 14704683)9 Lidke D.S....Jovin T.M. (2004)
    591. Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. (PubMed id 15314180)9 Wu X....Carraway K.L. (2004)
    592. Epidermal growth factor receptor inhibitors: a new prospective in the treatment of lung cancer. (PubMed id 15032719)9 Tiseo M....Ardizzoni A. (2004)
    593. Biomarkers in non-small cell lung cancer prevention. (PubMed id 15452456)9 Hilbe W....WAPll E. (2004)
    594. A structure-based model for ligand binding and dimerization of EGF receptors. (PubMed id 14732694)9 Klein P....Schlessinger J. (2004)
    595. Frequent overexpression of multiple ErbB receptors by head and neck squamous cell carcinoma contrasts with rare antibody immunity in patients. (PubMed id 15476268)9 Bei R....Muraro R. (2004)
    596. Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway. (PubMed id 14602723)9 Way T.D....Lin J.K. (2004)
    597. Roles of mitogen-activated protein kinase and phosphoinositide 3'-kinase in ErbB2/ErbB3 coreceptor-mediated heregulin signaling. (PubMed id 12651161)9 Vijapurkar U....Koland J.G. (2003)
    598. [Gene expression profiles of protein kinases and phosphatases obtained by hybridization with cDNA arrays: molecular portrait of human prostate carcinoma] (PubMed id 12624952)9 Kniazev I.u.P....Kniazev P.G. (2003)
    599. The EGF receptor family--multiple roles in proliferation, differentiation, and neoplasia with an emphasis on HER4. (PubMed id 12813928)9 Earp H.S....Sartor C.I. (2003)
    600. ErbBs in mammary development. (PubMed id 12648468)9 Stern D.F. (2003)
    601. Neuregulin-1 and erbB4 immunoreactivity is associated with neuritic plaques in Alzheimer disease brain and in a transgenic model of Alzheimer disease. (PubMed id 12528817)9 Chaudhury A.R....Carroll S.L. (2003)
    602. Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells. (PubMed id 12529413)9 Labriola L....Elizalde P.V. (2003)
    603. Inhibition of heregulin signaling by an aptamer that preferentially binds to the oligomeric form of human epidermal growth factor receptor-3. (PubMed id 12874383)9 Chen C.H....Landgraf R. (2003)
    604. Mechanism of action of anti-HER2 monoclonal antibodies: scientific update on trastuzumab and 2C4. (PubMed id 12908564)9 Albanell J....GascA^n P. (2003)
    605. Herstatin inhibits heregulin-mediated breast cancer cell growth and overcomes tamoxifen resistance in breast cancer cells that overexpress HER-2. (PubMed id 14603258)9 Jhabvala-Romero F....Clinton G.M. (2003)
    606. Betacellulin and amphiregulin induce upregulation of cyclin D1 and DNA synthesis activity through differential signaling pathways in vascular smooth muscle cells. (PubMed id 12869389)9 Shin H.S....Koh G.Y. (2003)
    607. Blockage of heregulin expression inhibits tumorigenicity and metastasis of breast cancer. (PubMed id 12569369)9 Tsai M.S....Lupu R. (2003)
    608. Disabling receptor ensembles with rationally designed interface peptidomimetics. (PubMed id 12011054)9 Berezov A....Murali R. (2002)
    609. Epidermal growth factor receptor family in lung cancer and premalignancy. (PubMed id 11894009)9 Franklin W.A....Bunn P.A. (2002)
    610. C-erbB receptors in squamous cell carcinomas of the head and neck: clinical significance and correlation with matrix metalloproteinases and vascular endothelial growth factors. (PubMed id 11755824)9 O-charoenrat P....Eccles S.A. (2002)
    611. The effectiveness of double-stranded short inhibitory RNAs (siRNAs) may depend on the method of transfection. (PubMed id 12568315)9 Walters D.K. and Jelinek D.F. (2002)
    612. Estrogen-related receptor alpha and estrogen-related receptor gamma associate with unfavorable and favorable biomarkers, respectively, in human breast cancer. (PubMed id 12438245)9 Ariazi E.A....Mertz J.E. (2002)
    613. Differential regulation of tumor angiogenesis by distinct ErbB homo- and heterodimers. (PubMed id 12429844)9 Yen L....Alaoui-Jamali M.A. (2002)
    614. Replacement of N-terminal portions of TGF-alpha with corresponding heregulin sequences affects ligand-induced receptor signaling and intoxication of tumor cells by chimeric growth-factor toxins. (PubMed id 11774287)9 Schmidt M. and Wels W. (2002)
    615. Type 1 protein tyrosine kinases in breast carcinoma: a review. (PubMed id 12184370)9 Suo Z. and Nesland J.M. (2002)
    616. Epidermal growth factor receptor signaling pathways are associated with tumorigenesis in the Nf1:p53 mouse tumor model. (PubMed id 12154062)9 Li H....DeClue J.E. (2002)
    617. Muscarinic receptors mediate phospholipase C-dependent activation of protein kinase B via Ca2+, ErbB3, and phosphoinositide 3-kinase in 1321N1 astrocytoma cells. (PubMed id 11694521)9 Tang X....Downes C.P. (2002)
    618. Autocrine heregulin generates growth factor independence and blocks apoptosis in colon cancer cells. (PubMed id 11791178)9 Venkateswarlu S....Brattain M.G. (2002)
    619. Transactivation of ErbB2 and ErbB3 by tumor necrosis factor-alpha and anisomycin leads to impaired insulin signaling through serine/threonine phosphorylation of IRS proteins. (PubMed id 11779863)9 Hemi R....Kanety H. (2002)
    620. Heregulin up-regulates heat shock protein-70 expression in breast cancer cells. (PubMed id 12174871)9 Mandal M....Kumar R. (2002)
    621. Human betacellulin structure modeled from other members of EGF family. (PubMed id 12111392)9 Lopez-Torrejon I....Oliva B. (2002)
    622. Functions of epidermal growth factor-like growth factors during human urothelial reepithelialization in vitro and the role of erbB2. (PubMed id 12202942)9 Bindels E.M....de Boer W.I. (2002)
    623. Characterization of the malignant melanoma of soft-parts cell line GG-62 by expression analysis using DNA microarrays. (PubMed id 12021921)9 Schaefer K.L....Dockhorn-Dworniczak B. (2002)
    624. Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors. (PubMed id 12134143)9 Camenisch T.D....McDonald J.A. (2002)
    625. Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2. (PubMed id 11739740)9 Esparis-Ogando A....Pandiella A. (2002)
    626. The peroxisome proliferator-activated receptor gamma is an inhibitor of ErbBs activity in human breast cancer cells. (PubMed id 11739643)9 Pignatelli M....Perez-Castillo A. (2001)
    627. Assessment of differential expression of oncogenes in gastric adenocarcinoma by fluorescent multiplex RT-PCR assay. (PubMed id 11678335)9 Rajcevic U....Komel R. (2001)
    628. Intracellular expression of the truncated extracellular domain of c-erbB-3/HER3. (PubMed id 11369513)9 Srinivasan R....Gullick W.J. (2001)
    629. The expression of HPV-16 E5 protein in squamous neopl astic changes in the uterine cervix. (PubMed id 11287752)9 Chang J.L....Chen S.L. (2001)
    630. Ribozyme targeting of HER-2 inhibits pancreatic cancer cell growth in vivo. (PubMed id 11527697)9 Thybusch-Bernhardt A....Juhl H. (2001)
    631. Isolation of the melanoma-associated antigen p23 using antibody phage display. (PubMed id 11123321)9 Li J....Herlyn D. (2001)
    632. [The c-erbB-related oncoproteins in normal placenta and in gestational trophoblastic diseases (in vitro study)] (PubMed id 11424588)9 FA1lAPp V....Doszpod J. (2001)
    633. Characterization of ten newly-derived human head and neck squamous carcinoma cell lines with special reference to c-erbB proto-oncogene expression. (PubMed id 11497283)9 O-Charoenrat P....Eccles S. (2001)
    634. Expression of EGFR family and steroid hormone receptors in ductal carcinoma in situ of the breast. (PubMed id 11758715)9 Suo Z....Nesland J.M. (2001)
    635. Signaling molecules implicated in heregulin induction of growth arrest and apoptosis. (PubMed id 11605034)9 Guerra-Vladusic F.K....Lupu R. (2001)
    636. The tyrosine kinase inhibitor ZD1839 ('Iressa') inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. (PubMed id 11585753)9 Moasser M.M....Rosen N. (2001)
    637. CI-1033, a pan-erbB tyrosine kinase inhibitor. (PubMed id 11706399)9 Slichenmyer W.J....Fry D.W. (2001)
    638. Differential utilization and localization of ErbB receptor tyrosine kinases in skin compared to normal and malignant keratinocytes. (PubMed id 11571634)9 Stoll S.W....Elder J.T. (2001)
    639. The transmembrane heregulin precursor is functionally active. (PubMed id 11495899)9 Aguilar Z. and Slamon D.J. (2001)
    640. Expression of herstatin, an autoinhibitor of HER-2/neu, inhibits transactivation of HER-3 by HER-2 and blocks EGF activation of the EGF receptor. (PubMed id 11526509)9 Azios N.G....Clinton G.M. (2001)
    641. The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells. (PubMed id 11313882)9 Bowers G....Schmidt-Ullrich R.K. (2001)
    642. Human EGF receptor (HER) family and heregulin members are differentially expressed in epidermal keratinocytes and modulate differentiation. (PubMed id 11716544)9 De Potter I.Y....Pittelkow M.R. (2001)
    643. A novel role of neuregulin in skeletal muscle. Neuregulin stimulates glucose uptake, glucose transporter translocation, and transporter expression in muscle cells. (PubMed id 11278386)9 SuA!rez E....GumA! A. (2001)
    644. Ligand-mediated cytolysis of tumor cells: use of heregulin-zeta chimeras to redirect cytotoxic T lymphocytes. (PubMed id 10678365)9 Muniappan A....Talib S. (2000)
    645. TCDD elevates erbB2 expression and signaling in T47D cells by reversing serum potentiation of estrogen receptor activity, independent of estrogen levels and enhanced ER down-regulation. (PubMed id 11162886)9 Angus W.G....Jefcoate C.R. (2000)
    646. Cell death induced by TNF or serum starvation is independent of ErbB receptor signaling in MCF-7 breast carcinoma cells. (PubMed id 10797281)9 Egeblad M. and Jaattela M. (2000)
    647. Relationship of c-myc and erbB oncogene family gene aberrations and other selected factors to ex vivo chemosensitivity of ovarian cancer in the modified ATP-chemosensitivity assay. (PubMed id 10961689)9 Vogt U....Schlotter C.M. (2000)
    648. Molecular mechanisms underlying ErbB2/HER2 action in breast cancer. (PubMed id 11156523)9 Harari D. and Yarden Y. (2000)
    649. Ectopic expression of the ErbB-3 binding protein ebp1 inhibits growth and induces differentiation of human breast cancer cell lines. (PubMed id 10797306)9 Lessor T.J....Hamburger A.W. (2000)
    650. Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers. (PubMed id 10749108)9 Srinivasan R....Gullick W.J. (2000)
    651. Heregulin-beta is especially potent in activating phosphatidylinositol 3-kinase in nontransformed human mammary epithelial cells. (PubMed id 10797304)9 Ram T.G....Ethier S.P. (2000)
    652. Differential signaling by an anti-p185(HER2) antibody and heregulin. (PubMed id 10910064)9 Le X.F....Bast R.C. (2000)
    653. Role of HER2 gene overexpression in breast carcinoma. (PubMed id 10623878)9 MAcnard S....Pupa S.M. (2000)
    654. Expression of epidermal growth factor receptor-related family products in gestational trophoblastic diseases and normal placenta and its relationship with development of postmolar tumor. (PubMed id 10831347)9 Tuncer Z.S....Berkowitz R.S. (2000)
    655. Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis. (PubMed id 10918604)9 Yen L....Alaoui-Jamali M.A. (2000)
    656. Ethanol enhances erbB-mediated migration of human breast cancer cells in culture. (PubMed id 11079160)9 Luo J. and Miller M.W. (2000)
    657. EGF activates ErbB-2 and stimulates phosphatidylinositol 3-kinase in human airway smooth muscle cells. (PubMed id 9950886)9 Krymskaya V.P....Panettieri R.A. (1999)
    658. Expression of P185erbB-2, P160erbB-3, P180erbB-4, and heregulin alpha in human normal bronchial epithelial and lung cancer cell lines. (PubMed id 10226586)9 al Moustafa A.E....O'Connor-McCourt M. (1999)
    659. Heregulin beta1-activated phosphatidylinositol 3-kinase enhances aggregation of MCF-7 breast cancer cells independent of extracellular signal-regulated kinase. (PubMed id 10197638)9 Tan M....Yu D. (1999)
    660. Regulation of cyclooxygenase-2 pathway by HER2 receptor. (PubMed id 9927187)9 Vadlamudi R....Kumar R. (1999)
    661. Phosphotyrosine binding domains of Shc and insulin receptor substrate 1 recognize the NPXpY motif in a thermodynamically distinct manner. (PubMed id 10037694)9 Farooq A....Zhou M.M. (1999)
    662. Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase. (PubMed id 10353604)9 Elenius K....Klagsbrun M. (1999)
    663. NDF/heregulin-induced cell cycle changes and apoptosis in breast tumour cells: role of PI3 kinase and p38 MAP kinase pathways. (PubMed id 10376522)9 Daly J.M....Hynes N.E. (1999)
    664. Receptor tyrosine kinase and p16/CDKN2 expression in a case of tripe palms associated with non-small-cell lung cancer. (PubMed id 10640836)9 KrAohn G....Peter R.U. (1999)
    665. Evaluation of biomarker modulation by fenretinide in prostate cancer patients. (PubMed id 10325501)9 Urban D....Grizzle W. (1999)
    666. Neu differentiation factor stimulates phosphorylation and activation of the Sp1 transcription factor. (PubMed id 10022883)9 Alroy I....Yarden Y. (1999)
    667. Formation of distinct signalling complexes involving phosphatidylinositol 3-kinase activity with stimulation of epidermal growth factor or insulin-like growth factor-I in human skin fibroblasts. (PubMed id 9886492)9 Takahashi Y....Kadowaki T. (1999)
    668. ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases. (PubMed id 10358079)9 Olayioye M.A....Hynes N.E. (1999)
    669. Binding specificities and affinities of egf domains for ErbB receptors. (PubMed id 10214951)9 Jones J.T....Sliwkowski M.X. (1999)
    670. Neuregulin-increased expression of acetylcholine receptor epsilon-subunit gene requires ErbB interaction with Shc. (PubMed id 10582594)9 Won S....Mei L. (1999)
    671. Biologic effects of heregulin/neu differentiation factor on normal and malignant human breast and ovarian epithelial cells. (PubMed id 10557094)9 Aguilar Z....Slamon D.J. (1999)
    672. The expression of type I growth factor receptors in the squamous neoplastic changes of uterine cervix. (PubMed id 10094882)9 Chang J.L....Chen S.L. (1999)
    673. Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase. (PubMed id 10348342)9 Harari D....Yarden Y. (1999)
    674. Ribozyme-mediated down-regulation of ErbB-4 in estrogen receptor-positive breast cancer cells inhibits proliferation both in vitro and in vivo. (PubMed id 10537315)9 Tang C.K....Lippman M.E. (1999)
    675. Laminin receptor alpha6beta4 integrin is highly expressed in ENU-induced glioma in rat. (PubMed id 10088672)9 Previtali S.C....Wrabetz L. (1999)
    676. Granulosa cell tumors express erbB4 and are sensitive to the cytotoxic action of heregulin-beta2/PE40. (PubMed id 9581810)9 Furger C....Sutherland R.L. (1998)
    677. Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers. (PubMed id 9628875)9 Lenferink A.E....Yarden Y. (1998)
    678. Type 1 protein tyrosine kinases in benign and malignant breast lesions. (PubMed id 9870145)9 Suo Z....Nesland J.M. (1998)
    679. Inhibition of cell proliferation by 17beta-estradiol and heregulin beta1 in estrogen receptor negative human breast carcinoma cell lines. (PubMed id 9877030)9 Yoo J.Y....Hamburger A.W. (1998)
    680. Synergistic regulation of Schwann cell proliferation by heregulin and forskolin. (PubMed id 9774641)9 Rahmatullah M....Carey D.J. (1998)
    681. Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells. (PubMed id 9590694)9 Qiu Y....Kung H.J. (1998)
    682. Signal transduction by epidermal growth factor and heregulin via the kinase-deficient ErbB3 protein. (PubMed id 9693119)9 Kim H.H....Koland J.G. (1998)
    683. Targeted expression of activated erbB-2 to the epidermis of transgenic mice elicits striking developmental abnormalities in the epidermis and hair follicles. (PubMed id 9563851)9 Xie W....Kudlow J.E. (1998)
    684. Heparin-binding EGF-like growth factor in the human prostate: synthesis predominantly by interstitial and vascular smooth muscle cells and action as a carcinoma cell mitogen. (PubMed id 9518259)9 Freeman M.R....Klagsbrun M. (1998)
    685. Alternative intracellular routing of ErbB receptors may determine signaling potency. (PubMed id 9593726)9 Waterman H....Yarden Y. (1998)
    686. Cytotoxic activity of epidermal growth factor-genistein against breast cancer cells. (PubMed id 9563884)9 Uckun F.M....Myers D.E. (1998)
    687. Recombinant heregulin-Pseudomonas exotoxin fusion proteins: interactions with the heregulin receptors and antitumor activity in vivo. (PubMed id 9563895)9 Yang D....Lippman M.E. (1998)
    688. ErbB tyrosine kinases and the two neuregulin families constitute a ligand-receptor network. (PubMed id 9742126)9 Pinkas-Kramarski R....Alamandi M. (1998)
    689. The oncogenic ErbB-2/ErbB-3 heterodimer is a surrogate receptor of the epidermal growth factor and betacellulin. (PubMed id 9546426)9 Pinkas-Kramarski R....Yarden Y. (1998)
    690. Biological response to ErbB ligands in nontransformed cell lines correlates with a specific pattern of receptor expression. (PubMed id 9832411)9 Sundaresan S....Mather J.P. (1998)
    691. Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer: amphiregulin and microvessel count are independent prognostic indicators of survival. (PubMed id 9516978)9 Fontanini G....Ciardiello F. (1998)
    692. The type 1 growth factor receptor family: new ligands and receptors and their role in breast cancer. (PubMed id 10066071)9 Gullick W.J. and Srinivasan R. (1998)
    693. Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus. (PubMed id 9199335)9 Busfield S.J....Gearing D.P. (1997)
    694. Activation of erbB2 and c-src in phorbol ester-treated mouse epidermis: possible role in mouse skin tumor promotion. (PubMed id 9136987)9 Xian W....DiGiovanni J. (1997)
    695. Heregulin and agonistic anti-p185(c-erbB2) antibodies inhibit proliferation but increase invasiveness of breast cancer cells that overexpress p185(c-erbB2): increased invasiveness may contribute to poor prognosis. (PubMed id 9815853)9 Xu F.J....Bast R.C. (1997)
    696. Heregulin-stimulated acetylcholine receptor gene expression in muscle: requirement for MAP kinase and evidence for a parallel inhibitory pathway independent of electrical activity. (PubMed id 9049301)9 Altiok N....Changeux J.P. (1997)
    697. Epidermal growth factor and betacellulin mediate signal transduction through co-expressed ErbB2 and ErbB3 receptors. (PubMed id 9312020)9 Alimandi M....Pierce J.H. (1997)
    698. Bivalence of EGF-like ligands drives the ErbB signaling network. (PubMed id 9305636)9 Tzahar E....Yarden Y. (1997)
    699. Characterization of human breast adenocarcinoma SK-BR-3 cells resistant to doxorubicin. (PubMed id 9372856)9 Osmak M....Skrk J. (1997)
    700. Phosphatidylinositol 3-kinase mediates heregulin-induced growth inhibition in human epithelial cells. (PubMed id 9216687)9 Hamburger A.W. and Yoo J.Y. (1997)
    701. Altered gene expression in drug-resistant human breast cancer cells. (PubMed id 9815641)9 Wosikowski K....Bates S.E. (1997)
    702. Association of csk-homologous kinase (CHK) (formerly MATK) with HER-2/ErbB-2 in breast cancer cells. (PubMed id 8999872)9 Zrihan-Licht S....Avraham H. (1997)
    703. A model for the activation of the epidermal growth factor receptor kinase involvement of an asymmetric dimer? (PubMed id 9092812)9 Groenen L.C....Treutlein H.R. (1997)
    704. Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. (PubMed id 8665853)9 Pinkas-Kramarski R....Yarden Y. (1996)
    705. A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor. (PubMed id 8816440)9 Tzahar E....Yarden Y. (1996)
    706. Expression of the type 1 tyrosine kinase growth factor receptors EGF receptor, c-erbB2 and c-erbB3 in bladder cancer. (PubMed id 8869284)9 Rajkumar T....Gullick W.J. (1996)
    707. Cytolysis of tumor cells expressing the Neu/erbB-2, erbB-3, and erbB-4 receptors by genetically targeted naive T lymphocytes. (PubMed id 9816261)9 Altenschmidt U....Groner B. (1996)
    708. NDF/heregulin induces persistence of terminal end buds and adenocarcinomas in the mammary glands of transgenic mice. (PubMed id 8622899)9 Krane I.M. and Leder P. (1996)
    709. erbB family receptor expression and growth regulation in a newly isolated human breast cancer cell line. (PubMed id 8631031)9 Ethier S.P....Dilts C.A. (1996)
    710. Insulin-like growth factor and epidermal growth factor independence in human mammary carcinoma cells with c-erbB-2 gene amplification and progressively elevated levels of tyrosine-phosphorylated p185erbB-2. (PubMed id 8597535)9 Ram T.G....Ethier S.P. (1996)
    711. Nonisotopic quantitation of mRNA using a novel RNase protection assay: measurement of erbB-2 mRNA in tumor cell lines. (PubMed id 8937564)9 Chan S.D....Wada H.G. (1996)
    712. Heregulin induces increase in sensitivity of an erbB-2-overexpressing breast cancer cell type to lysis by lymphokine-activated killer cells. (PubMed id 8917631)9 Cardillo M....Lupu R. (1996)
    713. Epidermal growth factor-related peptides activate distinct subsets of ErbB receptors and differ in their biological activities. (PubMed id 8626392)9 Beerli R.R. and Hynes N.E. (1996)
    714. ErbB receptor activation, cell morphology changes, and apoptosis induced by anti-Her2 monoclonal antibodies. (PubMed id 8806592)9 Kita Y....Nicolson M. (1996)
    715. The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4. (PubMed id 8702723)9 Riese D.J....Stern D.F. (1996)
    716. Expression of c-erbB-3 and c-erbB-4 proteins in papillary thyroid carcinomas. (PubMed id 8640794)9 Haugen D.R....Lillehaug J.R. (1996)
    717. Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors. (PubMed id 8834768)9 Friess H....Buchler M.W. (1996)
    718. ErbB2 activation and signal transduction in normal an d malignant mammary cells. (PubMed id 10887493)9 Hynes N.E. (1996)
    719. Type 1 receptor tyrosine kinases are differentially phosphorylated in mammary carcinoma and differentially associated with steroid receptors. (PubMed id 8579117)9 Bacus S.S....Stern D.F. (1996)
    720. Expression of chimeric envelope proteins in helper cell lines and integration into Moloney murine leukemia virus particles. (PubMed id 8732165)9 Schnierle B.S....Groner B. (1996)
    721. All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired. (PubMed id 8617810)9 Baulida J....Carpenter G. (1996)
    722. Oncogene expression in carotid body tumors. (PubMed id 8640709)9 Wang D.G....Buchanan K.D. (1996)

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    Entrez Gene: 2065 HGNC: 3431 AceView: ERBB3 Ensembl:ENSG00000065361 euGenes: HUgn2065
    ECgene: ERBB3 Kegg: 2065 H-InvDB: ERBB3

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    PharmGKB entry for ERBB3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ERBB3 Genetics and Cytogenetics in Oncology and Haematology

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     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ERBB3
    Customized:
     lentivirus for stable overexpression of ERBB3
     lentivirus expression plasmids for stable overexpression of ERBB3
     adenovirus for overexpression of ERBB3
     LSBio Antibodies in human, mouse, rat for ERBB3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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