Aliases for ERBB3 Gene
- Erb-B2 Receptor Tyrosine Kinase 3 2 3
- V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3 2 3
- Tyrosine Kinase-Type Cell Surface Receptor HER3 3 4
- Human Epidermal Growth Factor Receptor 3 2 3
- Proto-Oncogene-Like Protein C-ErbB-3 3 4
- EC 220.127.116.11 4 63
- LCCS2 3 6
- HER3 3 4
- Lethal Congenital Contracture Syndrome 2 2
- Receptor Tyrosine-Protein Kinase ErbB-3 3
External Ids for ERBB3 Gene
Previous HGNC Symbols for ERBB3 Gene
Previous GeneCards Identifiers for ERBB3 Gene
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for ERBB3 Gene
ERBB3 (Erb-B2 Receptor Tyrosine Kinase 3) is a Protein Coding gene. Diseases associated with ERBB3 include lethal congenital contractural syndrome 2 and gestational trophoblastic tumor. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is TNK1.
UniProtKB/Swiss-Prot for ERBB3 Gene
Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5.
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4). EGFR signaling is initiated by ligand binding to the extracellular ligand binding domain. This initiates receptor homo-/hetero-dimerization and autophosphorylation by the intracellular kinase domain, resulting in receptor activation. Following activation, phosphorylation of cytoplasmic substrates occurs and a signaling cascade is initiated that drives many cellular responses, including changes in gene expression, cytoskeletal rearrangement, anti-apoptosis and increased cell proliferation.