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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ERBB3 Gene

protein-coding   GIFtS: 74
GCID: GC12P056473

v-erb-b2 erythroblastic leukemia viral oncogene homolog...

(Previous name: lethal congenital contracture syndrome 2 )
(Previous symbol: LCCS2)
 Explore 87 diseases affiliated with
ERBB3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ERBB3    

Aliases
for ERBB3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian)1 2     C-ErbB-31
HER31 2 3     C-ErbB31
LCCS21 2 5     ErbB3-S1
Proto-Oncogene-Like Protein C-ErbB-32 3     P180-ErbB31
Tyrosine Kinase-Type Cell Surface Receptor HER32 3     P45-SErbB31
EC 2.7.10.13 8     P85-SErbB31
Lethal Congenital Contracture Syndrome 21     Receptor Tyrosine-Protein Kinase ErbB-32
ErbB-32     EC 2.7.108
MDA-BF-12     

External Ids:    HGNC: 34311   Entrez Gene: 20652   Ensembl: ENSG000000653617   OMIM: 1901515   UniProtKB: P218603   

Export aliases for ERBB3 gene to outside databases

Previous GC identifers: GC12M056386 GC12M056841 GC12P056190 GC12P054760 GC12P053512


Summaries
for ERBB3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ERBB3:
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This
membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this
ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers
with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of
pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its
protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate
transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the
intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound
form. Additional splice variants have also been reported, but they have not been thoroughly characterized. (provided
by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ERBB3_HUMAN, P21860
Function: Binds and is activated by neuregulins and NTAK

summary for ERBB3:
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members
of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4).
EGFR signaling is initiated by ligand binding to the extracellular ligand binding domain. This initiates
receptor homo-/hetero-dimerization and autophosphorylation by the intracellular kinase domain, resulting in
receptor activation. Following activation, phosphorylation of cytoplasmic substrates occurs and a signaling
cascade is initiated that drives many cellular responses, including changes in gene expression, cytoskeletal
rearrangement, anti-apoptosis and increased cell proliferation.

Gene Wiki entry for ERBB3


Genomic Views
for ERBB3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ERBB3 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ERBB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ERBB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ERBB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13

ERBB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ERBB3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P056473:  view genomic region     (about GC identifiers)

Start:
 56,473,641 bp from pter      End:
 56,497,289 bp from pter
Size:
 23,649 bases      Orientation:
 plus strand

Proteins
for ERBB3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ERBB3_HUMAN, P21860 (See protein sequence)
Recommended Name: Receptor tyrosine-protein kinase erbB-3 precursor  
Size: 1342 amino acids; 148098 Da
Subunit: Monomer and homodimer. Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5,
PA2G4, GRB7 and MUC1
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Secreted
Developmental stage: Overexpressed in a subset of human mammary tumors
5 PDB 3D structures from and Proteopedia for ERBB3:
1M6B (3D)        2L9U (3D)        3KEX (3D)        3LMG (3D)        3P11 (3D)    
Secondary accessions: A8K6L6 B4DIK7 B4DV32 E9PDT8 Q9BUD7
Alternative splicing: 5 isoforms:  P21860-1   P21860-2   P21860-3   P21860-4   P21860-5   

Explore the universe of human proteins at neXtProt for ERBB3: NX_P21860

Post-translational modifications:

  • Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of
    • phosphatidylinositol 3-kinase (By similarity). Subject to autophosphorylation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P21860

    • 4/22 DME Specific Peptides for ERBB3 (P21860) (see all 22)
     YGVTVWE  DTDCFAC  KETELRK  TCNGSGS 

    ERBB3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001005915.1  NP_001973.2  

    ENSEMBL proteins: 
     ENSP00000448636   ENSP00000449138   ENSP00000267101   ENSP00000415753   ENSP00000448671  
     ENSP00000448483   ENSP00000447510   ENSP00000449713   ENSP00000408340   ENSP00000448946  
     ENSP00000449129   ENSP00000448729   ENSP00000446909   ENSP00000399178  
    Reactome Protein details: P21860
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant ERBB3 Protein
    R&D Systems Recombinant & Natural Proteins for ERBB3 (ErbB3/Her3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 3): ERBB3
    OriGene Protein Over-expression Lysate (see all 3): ERBB3
    OriGene Custom Protein Services for ERBB3 
    GenScript Purified and Recombinant Proteins for ERBB3
    Novus Biologicals ERBB3 Proteins
    Novus Biologicals ERBB3 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for ERBB3
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA11389077
    GO:0005634nucleus ----
    GO:0005886plasma membrane TAS17701904
    GO:0005887integral to plasma membrane TAS2687875
    GO:0016020membrane ----


    ERBB3 for ontologies           About GeneDecksing



    ERBB3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ERBB3
    R&D Systems Antibodies for ERBB3 (ErbB3/Her3)
    Cell Signaling Technology (CST) Antibodies for ERBB3  (HER3)
    OriGene Antibodies (see all 2): ERBB3
    OriGene Custom Antibody Services for ERBB3 
    GenScript Superior Antibodies for ERBB3
    Novus Biologicals ERBB3 Antibodies
    Abcam antibodies for ERBB3 
    Browse Antibodies at Uscn
    ThermoFisher Antibody for ERBB3

    Assay Products for ERBB3: 
    EMD Millipore Kits and Assays for the Analysis of ERBB3
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for ERBB3 (ErbB3/Her3)         (see all)
    GenScript Custom Assay Services for ERBB3
    Cell Signaling Technology (CST) Sandwich ELISA Kits for ERBB3 (HER3)
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for ERBB3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ERBB3 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR006212 Furin_repeat
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR000494 EGF_rcpt_L
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P21860

    ProtoNet protein and cluster: P21860

    4 Blocks protein families:
    IPB000494 Epidermal growth-factor receptor (EGFR)
    IPB006211 Furin-like cysteine rich region
    IPB006212 Furin-like repeat
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: ERBB3_HUMAN, P21860
    Domain: The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing
    proteins
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for ERBB3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ERBB3_HUMAN, P21860
    Function: Binds and is activated by neuregulins and NTAK
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for ERBB3:
    avian erythroblastic leukemia,viral (v-erb-b) oncogene homolog 3,heregulin beta 1 receptor,signal transducer
    receptor,heterodimerizing with the ligand less recetpor ERBB2

    Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

    miRNA
    Products:            		miRTarBase miRNAs that target ERBB3:
    hsa-mir-125a-5p (MIRT005117), hsa-mir-125b (MIRT002938), hsa-mir-205 (MIRT003659)

    OriGene 3'-UTR Clone (see all 2): ERBB3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ERBB3
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate ERBB3 (see all 57):
    hsa-miR-106a hsa-miR-301a hsa-miR-500a hsa-miR-766 hsa-miR-519a hsa-miR-877* hsa-miR-93 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: ERBB3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ERBB3 (see all 7)
    OriGene shRNA RFP: ERBB3
    OriGene siRNA: ERBB3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ERBB3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ERBB3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ERBB3 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ERBB3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ERBB3 (NM_001005915)
    Sino Biological Human cDNA Clone for ERBB3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERBB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERBB3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ERBB3
    Search LifeMap BioReagents cell lines for ERBB3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERBB3

    Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713NOT protein tyrosine kinase activity IDA7556068
    GO:0004714transmembrane receptor protein tyrosine kinase activity IEA--
    GO:0004872receptor activity ----
    GO:0004888transmembrane signaling receptor activity ISS7514177


    ERBB3 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for ERBB3:
     Decreased substrate adherent c  Decreased viability  Increased cell death HMECs cel  Synthetic lethal with c-Myc af 

    Animal Models:
         Mouse knock-outs for ERBB3: Erbb3tm1.1Dwt Erbb3tm1Gne Erbb3tm1Cbm Erbb3tm2Cbm
         15/17 MGI mutant phenotypes (inferred from 11 alleles) (MGI details for Erbb3) (see all 17):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  homeostasis/metabolism  immune system  integument 
     mortality/aging  muscle  nervous system  normal  pigmentation 

    ERBB3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ERBB3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/37 super-pathways (see all 37) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    2PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    		PIP3 activates AKT signaling1.00
    		PI3K/AKT activation0.97
    		PI3K/AKT Signaling in Cancer1.00
    		GAB1 signalosome0.96
    		PI3K events in ERBB2 signaling1.00
    		Constitutive PI3K/AKT Signaling in Cancer0.88
    		PI3K events in ERBB4 signaling1.00
    		Signaling by SCF-KIT0.72
    3GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    		P2Y Receptor Signaling0.38
    4Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    5Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		14-3-3 Induced Intracellular Signaling0.59
    		GSK3 Signaling0.61
    		eNOS Signaling0.48

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for ERBB3
        Apoptosis and survival Role of CDK5 in neuronal death and survival
    Development ERBB-family signaling
    Development Ligand-independent activation of ESR1 and ESR2

    5/35 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ERBB3 (see all 35)
        Paxillin Interactions
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    JNK Pathway
    Tec Kinases Signaling

    1 Cell Signaling Technology (CST) Pathway for ERBB3
        Tyrosine Kinases / Adaptors

    4 Tocris Bioscience Pathways for ERBB3
        Akt Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    MAPK Pathway

    3 GeneGo (Thomson Reuters) Pathways for ERBB3
        Development ERBB-family signaling
    Development Ligand-independent activation of ESR1 and ESR2
    Apoptosis and survival Role of CDK5 in neuronal death and survival

    5/7 BioSystems Pathways for ERBB3 (see all 7) 
        ErbB signaling pathway
    Signaling Pathways in Glioblastoma
    Heart Development
    IL-6 Signaling Pathway
    a6b1 and a6b4 Integrin signaling

    5/32        Reactome Pathways for ERBB3 (see all 32)
        Signaling by EGFR in Cancer
    Downregulation of ERBB2:ERBB3 signaling
    Disease
    Signaling by ERBB2
    GAB1 signalosome

    1 PharmGKB Pathway for ERBB3
        EGFR Inhibitor Pathway, Pharmacodynamics

    3         Kegg Pathways  (Kegg details for ERBB3):
        ErbB signaling pathway
    Calcium signaling pathway
    Endocytosis


    ERBB3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ERBB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/100 Interacting proteins for ERBB3 (P218601, 2, 3 ENSP000002671014) via UniProtKB, MINT, STRING, and/or I2D (see all 100)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279861, 2, 3, ENSP000002743354EBI-720706,EBI-79464 MINT-74605 MINT-74614 MINT-74600 MINT-74611 MINT-74604 MINT-74616 MINT-74613 MINT-74601 MINT-74612 MINT-74617 MINT-74615 MINT-74597 MINT-74602 MINT-74596 MINT-74603 I2D: score=7 STRING: ENSP00000274335
    PIK3R3Q925692, 3, ENSP000002627414MINT-74643 MINT-74669 MINT-74652 MINT-74647 MINT-74651 MINT-74656 MINT-74653 MINT-74672 MINT-74644 MINT-74668 MINT-74646 MINT-74645 MINT-74667 MINT-74654 MINT-74666 MINT-74665 MINT-74657 MINT-74670 MINT-74655 MINT-74671 I2D: score=2 STRING: ENSP00000262741
    ABL2P426842, 3, ENSP000003565954MINT-74450 MINT-74445 MINT-74452 MINT-74446 MINT-74447 MINT-74451 MINT-74448 MINT-74453 MINT-74449 MINT-74454 I2D: score=2 STRING: ENSP00000356595
    PIK3R2O004592, 3, ENSP000002222544MINT-74627 MINT-74618 MINT-61512 MINT-74629 MINT-74637 MINT-61520 MINT-74625 MINT-74638 MINT-61513 MINT-74624 MINT-74636 MINT-74633 MINT-74628 MINT-61519 MINT-74626 MINT-74639 MINT-61516 MINT-74635 MINT-74634 MINT-61517 I2D: score=5 STRING: ENSP00000222254
    GRB7Q144512, 3, ENSP000003107714MINT-74546 MINT-74548 MINT-74545 MINT-74547 MINT-8027964 MINT-8034751 I2D: score=5 STRING: ENSP00000310771
    About this table

    Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003197endocardial cushion development IEA--
    GO:0007162negative regulation of cell adhesion IDA7556068
    GO:0007165signal transduction IDA10572067
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway ISS7514177
    GO:0007409axonogenesis ----


    ERBB3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ERBB3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ERBB3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ERBB3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    HDS 029Potent inhibitor of the ErbB receptor family--
    JNJ 28871063 hydrochloridePotent ErbB receptor family inhibitor[944341-54-2]
    PD 158780Potent ErbB receptor family inhibitor[171179-06-9]

    2 HMDB Compounds for ERBB3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    10/47 Novoseek chemical compound relationships for ERBB3 gene (see all 47)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 83.3 232 7514177 (4), 7929151 (4), 8058768 (4), 11189010 (3) (see all 99)
    pertuzumab 81.7 15 19737968 (6), 17627612 (3), 18632642 (2), 17547474 (1) (see all 5)
    hrgbeta1 81.6 3 12209601 (2)
    gefitinib 81.5 55 15731348 (7), 18803287 (5), 17638894 (4), 16818711 (3) (see all 20)
    trastuzumab 79.3 18 20103628 (5), 18625725 (2), 19276389 (1), 19934333 (1) (see all 12)
    lapatinib 77.3 6 16020981 (1), 18334972 (1), 14737100 (1), 15755991 (1)
    erlotinib 69.3 17 16928826 (7), 17457047 (5)
    cetuximab 69.1 8 19276677 (2), 18297114 (2), 15585383 (1), 16424038 (1) (see all 6)
    phosphatidylinositol 64.8 45 7929151 (5), 7535767 (4), 9886492 (2), 8732665 (2) (see all 22)
    ag 1478 57.2 3 18682844 (1), 10533979 (1)

    Search CenterWatch for drugs/clinical trials and news about ERBB3 

    Transcripts
    for ERBB3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ERBB3 gene (2 alternative transcripts): 
    NM_001005915.1  NM_001982.3  

    Unigene Cluster for ERBB3:

    V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
    Hs.118681  [show with all ESTs]
    Unigene Representative Sequence: NM_001982
    18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000549282 ENST00000549061 ENST00000267101(uc001sjh.3 uc009zoj.3 uc010sqb.2 uc010sqc.2 uc009zok.3 uc001sjk.3)
    ENST00000411731(uc001sjg.3) ENST00000550869 ENST00000551085 ENST00000546884
    ENST00000551242 ENST00000549672 ENST00000415288(uc001sjj.1) ENST00000549472
    ENST00000546748 ENST00000551176(uc001sji.3) ENST00000549205 ENST00000550828
    ENST00000550070 ENST00000549644 ENST00000553131

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): ERBB3
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ERBB3
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate ERBB3 (see all 57):
    hsa-miR-106a hsa-miR-301a hsa-miR-500a hsa-miR-766 hsa-miR-519a hsa-miR-877* hsa-miR-93 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: ERBB3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ERBB3 (see all 7)
    OriGene shRNA RFP: ERBB3
    OriGene siRNA: ERBB3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ERBB3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ERBB3 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ERBB3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ERBB3 (NM_001005915)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERBB3 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ERBB3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ERBB3

    Additional cDNA sequence: 

    AF086028.1 AK124710.1 AK125028.1 AK291681.1 AK294719.1 AK295650.1 AK300909.1 BC002706.2 
    BC041579.1 BC082992.1 BT007226.1 M29366.1 M34309.1 S61953.1 U88357.1 U88358.1 
    U88359.1 U88360.1 

    20 DOTS entries:

    DT.98131702  DT.95179527  DT.100791868  DT.95102464  DT.101982408  DT.100700960  DT.213585  DT.100038754 
    DT.91963462  DT.75114482  DT.95184370  DT.86837952  DT.92440238  DT.101982406  DT.121128974  DT.121129014 
    DT.95082546  DT.121634328  DT.444493  DT.91823725 

    24/234 AceView cDNA sequences (see all 234):

    AI973035 BU185466 BQ023875 BU168324 AA574146 BU160943 BQ877641 AI873699 
    AU121609 BE304403 AL696259 AW949549 AW375856 BC002706 CR621450 M34309 
    BP357593 BU179810 NM_001982 CB142393 BF198019 BE893699 BM976983 AF086028 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ERBB3 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^ 17 ^
    SP1:                          -                 -                                                                                         -           -         
    SP2:                                                                                                                                      -           -         
    SP3:                                                                                                                                                            
    SP4:                          -                 -                                         -     -     -     -     -     -     -     -     -     -     -     -   
    SP5:                                                                                                                                                            

    ExUns: 18 ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29
    SP1:        -                             -           -                                                         
    SP2:        -           -     -     -     -     -     -                                                         
    SP3:                                      -           -                                                         
    SP4:  -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                     
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for ERBB3

    Expression
    for ERBB3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ERBB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCCGTAAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ERBB3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartAtrioventricular ValvesAtrioventricular Valve CellsEndocardium, Myocardium
    HeartSemilunar ValvesSemilunar Valve CellsEndocardium, Neural Crest
    HeartAtrioventricular Endocardial CushionEndocardial Cushion CellsEndocardium
    HeartEndocardiumEndocardial CellsEndocardium
    HeartEndocardiumCushion Mesenchymal CellsEndocardium
    KidneyUreteric BudUreteric Bud CellsKidney
    KidneyUreteric BudUreteric Bud Tip CellsKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ERBB3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ERBB3

    SOURCE GeneReport for Unigene cluster: Hs.118681

    UniProtKB/Swiss-Prot: ERBB3_HUMAN, P21860
    Tissue specificity: Epithelial tissues and brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including ERBB3 (see all 6): 
              Lung Cancer in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              Cancer Drug Targets in human mouse rat
              Multiple Sclerosis in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

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    In Situ
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERBB3

    Orthologs
    for ERBB3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ERBB3 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ERBB31 v-erb-b2 erythroblastic leukemia viral oncogene homolog more 68.58(n)
    70.99(a)    		   693245  NM_001044669.1  NP_001038134.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ERBB36
    		 --
    		 66(a)
    		 1 ↔ 1
    		 GL343198.1(3672170-3705750)
    zebrafish
    (Danio rerio)    		 Actinopterygii erbb3b1 v-erb-b2 erythroblastic leukemia viral oncogene homolog more 58.3(n)
    57.55(a)    		   544664  NM_001014826.1  NP_001014826.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Egfr3 eggshell pattern formation epidermal growth
    factor more    		 39(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea let-233 tyrosine-protein kinase (Epidermal growth
    factor more    		 28(a)   II(9197428-9206848)   --


    ENSEMBL Gene Tree for ERBB3 (if available)
    TreeFam Gene Tree for ERBB3 (if available) 

    Paralogs
    for ERBB3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ERBB3 gene
    SYK2  TNK12  JAK22  JAK32  TNK22  TYK22  ERBB42  JAK12  
    PTK22  ERBB22  ZAP702  PTK2B2  EGFR2  
    10 SIMAP similar genes for ERBB3 using alignment to 10 protein entries:     ERBB3_HUMAN (see all proteins):
    c-erbB-3    ERBB4    EGFR    ERBB2    HER-2    ABL1
    EPHA2    tec    INSR    DKFZp686M05208

    ERBB3 for paralogs           About GeneDecksing



    Genomic Variants
    for ERBB3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/515 NCBI SNPs in ERBB3 are shown (see all 515)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1478025941,2
    		--56472042(+) GCCCAG/TCTAAT 2 -- us2k10--------
    rs1834990241,2
    		--56472052(+) TTTTTA/GTATTT 2 -- us2k10--------
    rs1894518901,2
    		--56472100(+) GTCTCA/GAACTC 2 -- us2k10--------
    rs1924880001,2
    		--56472126(+) CTGCCC/TGCCTC 2 -- us2k10--------
    rs349388371,2
    		C--56472279(+) GTCTC-/AAAAAA 2 -- us2k10--------
    rs1450070731,2
    		--56472286(+) AAAAAA/CAAAAA 2 -- us2k10--------
    rs764541111,2
    		--56472294(+) AAAAAA/GAAAAG 2 -- us2k10--------
    rs753413121,2
    		C,--56472299(+) GAAAAA/GAAAAA 2 -- us2k10--------
    rs1449111051,2
    		--56473315(+) CCGCCC/TCCCAT 2 -- us2k10--------
    rs1854578351,2
    		--56473492(+) ACACCA/CTCCCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ERBB3 (56473641 - 56497289 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ERBB3: --
    Human Gene Mutation Database (HGMD): ERBB3

    SABiosciences Cancer Mutation PCR Assays
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    Oncogenes & Tumor Suppressor Genes 384HC
    Gastric Cancer
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ERBB3
    DNA2.0 Custom Variant and Variant Library Synthesis for ERBB3

    Disorders / Diseases
    for ERBB3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ERBB3 for disorders           About GeneDecksing

    OMIM gene information: 190151   
    OMIM disorders: 607598  
    UniProtKB/Swiss-Prot: ERBB3_HUMAN, P21860
  • Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also
    • called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a
    neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2
    syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique
    feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology

    20/87 diseases for ERBB3 (see all 87):    About MalaCards
    lethal congenital contracture syndrome    lethal congenital contracture syndrome 2    lethal congenital contractural syndrome 2    congenital contractures
    charcot-marie-tooth disease    charcot-marie-tooth disease type 1    charcot-marie-tooth disease type 1a    estrogen-receptor positive breast cancer
    gestational trophoblastic tumor    prostatitis    non-small cell lung carcinoma    squamous cell carcinoma
    tooth disease    carotid body tumor    malignant pleural mesothelioma    endometrial stromal sarcoma
    leukemia    carcinoma    barrett's esophagus    laryngeal squamous cell carcinoma

    3 diseases from the University of Copenhagen DISEASES database for ERBB3:
    Breast cancer     Carcinoma     Lung cancer

    10/67 Novoseek disease relationships for ERBB3 gene (see all 67)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 72 111 17266042 (4), 18425425 (4), 18632642 (4), 15704104 (3) (see all 61)
    breast carcinoma 64.8 30 15770691 (3), 9823984 (2), 8732665 (2), 10473632 (2) (see all 21)
    tumors 61.5 169 18507044 (5), 18398842 (4), 19401448 (4), 11789762 (3) (see all 99)
    cancer 58.8 98 20215504 (5), 20179223 (4), 18404164 (3), 9712416 (3) (see all 57)
    viral leukemia 58.3 3 15150091 (1), 17275115 (1), 12021921 (1)
    nsclc 56.6 37 15731348 (6), 16843264 (3), 19648825 (2), 16288303 (2) (see all 19)
    carcinoma 47.2 55 9494565 (4), 7673253 (3), 11135221 (3), 8683379 (3) (see all 29)
    carcinoma non-small cell lung 43.6 3 9127320 (3)
    cancer lung 41.9 19 17631905 (3), 14739033 (2), 17627612 (2), 20351256 (1) (see all 13)
    metastasis 41.1 43 18398842 (5), 18172732 (3), 18698037 (3), 12888923 (2) (see all 24)

    Genetic Association Database (GAD): ERBB3
    Human Genome Epidemiology (HuGE) Navigator: ERBB3 (31 documents)
    Tumor Gene Database (TGDB): ERBB3

    Export disorders for ERBB3 gene to outside databases

    Publications
    for ERBB3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ERBB3 gene, integrated from 9 sources (see all 722):
    (articles sorted by number of sources associating them with ERBB3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase. (PubMed id 7685162)1, 2, 9 Katoh M.... Terada M. (1993)
    2. ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation. (PubMed id 20351256)1, 2, 9 Shi F....Lemmon M.A. (2010)
    3. Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3. (PubMed id 9516479)1, 2, 9 Fiddes R.J....Daly R.J. (1998)
    4. Neuroglycan C, a novel member of the neuregulin family. (PubMed id 15358134)1, 2, 9 Kinugasa Y....Higashiyama S. (2004)
    5. Lethal congenital contractural syndrome type 2 (LCCS2) is caused by a mutation in ERBB3 (Her3), a modulator of the phosphatidylinositol-3- kinase/Akt pathway. (PubMed id 17701904)1, 2 Narkis G.... Birk O.S. (2007)
    6. An extended association screen in multiple sclerosis using 202 microsatellite markers targeting apoptosis-related genes does not reveal new predisposing factors. (PubMed id 16143043)1, 4 Godde R....Epplen J.T. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein. (PubMed id 12939402)1, 2 Li Y....Kufe D. (2003)
    10. Structure of the extracellular region of HER3 reveals an interdomain tether. (PubMed id 12154198)1, 2 Cho H.S. and Leahy D.J. (2002)

    External Searches for ERBB3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ERBB3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2065 HGNC: 3431 AceView: ERBB3 Ensembl:ENSG00000065361 euGenes: HUgn2065
    ECgene: ERBB3 Kegg: 2065 H-InvDB: ERBB3

    Other Databases showing ERBB3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ERBB3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ERBB3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ERBB3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ERBB3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ERBB3 gene:
    Search GeneIP for patents involving ERBB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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