Aliases for ERBB2IP Gene
External Ids for ERBB2IP Gene
Previous GeneCards Identifiers for ERBB2IP Gene
This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for ERBB2IP Gene
ERBB2IP (Erbb2 Interacting Protein) is a Protein Coding gene. Diseases associated with ERBB2IP include cardiomyopathy, dilated, 1t. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include integrin binding and ErbB-2 class receptor binding. An important paralog of this gene is MFHAS1.
UniProtKB/Swiss-Prot for ERBB2IP Gene
Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated Tyr-1248 of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728).