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Aliases for ERBB2IP Gene

Aliases for ERBB2IP Gene

  • Erbb2 Interacting Protein 2 3
  • Densin-180-Like Protein 2 3 4
  • ERBIN 3 4 6
  • Erbb2-Interacting Protein 2 4
  • LAP2 3 4
  • Epididymis Secretory Protein Li 78 3
  • ERBB2-Interacting Protein 2
  • Protein LAP2 3
  • HEL-S-78 3
  • KIAA1225 4

External Ids for ERBB2IP Gene

Previous GeneCards Identifiers for ERBB2IP Gene

  • GC05P065374
  • GC05P066760
  • GC05P065192
  • GC05P065238
  • GC05P065225
  • GC05P065258
  • GC05P062180
  • GC05P065223

Summaries for ERBB2IP Gene

Entrez Gene Summary for ERBB2IP Gene

  • This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for ERBB2IP Gene

ERBB2IP (Erbb2 Interacting Protein) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by GPCR. GO annotations related to this gene include structural constituent of cytoskeleton and ErbB-2 class receptor binding. An important paralog of this gene is MFHAS1.

UniProtKB/Swiss-Prot for ERBB2IP Gene

  • Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated Tyr-1248 of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728).

Gene Wiki entry for ERBB2IP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERBB2IP Gene

Genomics for ERBB2IP Gene

Regulatory Elements for ERBB2IP Gene

Genomic Location for ERBB2IP Gene

65,926,475 bp from pter
66,082,549 bp from pter
156,075 bases
Plus strand

Genomic View for ERBB2IP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ERBB2IP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERBB2IP Gene

Proteins for ERBB2IP Gene

  • Protein details for ERBB2IP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein LAP2
    Protein Accession:
    Secondary Accessions:
    • A0AVR1
    • B4E3F1
    • B7ZLV9
    • E7EQW9
    • E9PCR8
    • Q1RMD0
    • Q86W38
    • Q9NR18
    • Q9NW48
    • Q9ULJ5

    Protein attributes for ERBB2IP Gene

    1412 amino acids
    Molecular mass:
    158298 Da
    Quaternary structure:
    • Interacts with ERBB2, BPAG1 and ITGB4 (PubMed:10878805, PubMed:11375975, PubMed:12444095). May favor the localization of ERBB2, by restricting its presence to the basolateral membrane of epithelial cells. Also found to interact with ARVCF and delta catenin (PubMed:11821434). Interacts (via C-terminus) with DST Isoform 3 (via N-terminus) (PubMed:11375975). Interacts with NOD2 (via CARD domain) (PubMed:16203728).
    • Sequence=AAH50692.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91538.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ERBB2IP Gene

    Alternative splice isoforms for ERBB2IP Gene

neXtProt entry for ERBB2IP Gene

Proteomics data for ERBB2IP Gene at MOPED

Post-translational modifications for ERBB2IP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ERBB2IP Gene

Domains for ERBB2IP Gene

Protein Domains for ERBB2IP Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96RT1
  • Contains 1 PDZ (DHR) domain.
  • Belongs to the LAP (LRR and PDZ) protein family.
  • Contains 17 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with ERBB2IP: view

No data available for Gene Families for ERBB2IP Gene

Function for ERBB2IP Gene

Molecular function for ERBB2IP Gene

UniProtKB/Swiss-Prot Function: Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated Tyr-1248 of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728).

Gene Ontology (GO) - Molecular Function for ERBB2IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005176 ErbB-2 class receptor binding TAS 11375975
GO:0005178 integrin binding IPI 11375975
GO:0005200 structural constituent of cytoskeleton NAS 11375975
GO:0005515 protein binding IPI 11375975
genes like me logo Genes that share ontologies with ERBB2IP: view

Phenotypes for ERBB2IP Gene

MGI mutant phenotypes for ERBB2IP:
inferred from 2 alleles
GenomeRNAi human phenotypes for ERBB2IP:
genes like me logo Genes that share phenotypes with ERBB2IP: view

Animal Models for ERBB2IP Gene

MGI Knock Outs for ERBB2IP:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ERBB2IP Gene

Localization for ERBB2IP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERBB2IP Gene

Cell junction, hemidesmosome. Nucleus membrane. Basolateral cell membrane. Note=Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for ERBB2IP Gene COMPARTMENTS Subcellular localization image for ERBB2IP gene
Compartment Confidence
nucleus 5
plasma membrane 5
extracellular 4
mitochondrion 3
cytosol 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for ERBB2IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005604 basement membrane TAS 10878805
GO:0005634 nucleus IDA 11375975
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 11375975
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with ERBB2IP: view

Pathways for ERBB2IP Gene

genes like me logo Genes that share pathways with ERBB2IP: view

Pathways by source for ERBB2IP Gene

1 KEGG pathway for ERBB2IP Gene

Gene Ontology (GO) - Biological Process for ERBB2IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting IEA --
GO:0007049 cell cycle NAS 11375975
GO:0007155 cell adhesion NAS 11375975
GO:0007165 signal transduction TAS 10878805
GO:0007173 epidermal growth factor receptor signaling pathway TAS 11375975
genes like me logo Genes that share ontologies with ERBB2IP: view

Compounds for ERBB2IP Gene

(2) Novoseek inferred chemical compound relationships for ERBB2IP Gene

Compound -log(P) Hits PubMed IDs
tyrosine 21.3 4
acetylcholine 16 1
genes like me logo Genes that share compounds with ERBB2IP: view

Transcripts for ERBB2IP Gene

Unigene Clusters for ERBB2IP Gene

Erbb2 interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ERBB2IP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23 ^
SP1: -
SP2: - -
SP3: - -

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c
SP1: -
SP2: -
SP3: - -

Relevant External Links for ERBB2IP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ERBB2IP Gene

mRNA expression in normal human tissues for ERBB2IP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ERBB2IP Gene

SOURCE GeneReport for Unigene cluster for ERBB2IP Gene Hs.591774

mRNA Expression by UniProt/SwissProt for ERBB2IP Gene

Tissue specificity: Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine.
genes like me logo Genes that share expressions with ERBB2IP: view

No data available for mRNA differential expression in normal tissues for ERBB2IP Gene

Orthologs for ERBB2IP Gene

This gene was present in the common ancestor of animals.

Orthologs for ERBB2IP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ERBB2IP 35
  • 99.74 (n)
  • 99.79 (a)
  • 100 (a)
(Bos Taurus)
Mammalia ERBB2IP 35
  • 92.51 (n)
  • 92.77 (a)
  • 90 (a)
(Canis familiaris)
Mammalia ERBB2IP 35
  • 92.9 (n)
  • 93.09 (a)
  • 93 (a)
(Mus musculus)
Mammalia Erbb2ip 35
  • 88.98 (n)
  • 90.35 (a)
Erbb2ip 16
Erbb2ip 36
  • 88 (a)
(Monodelphis domestica)
Mammalia ERBB2IP 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia ERBB2IP 36
  • 74 (a)
(Rattus norvegicus)
Mammalia RGD1562952 35
  • 88.88 (n)
  • 89.12 (a)
(Gallus gallus)
Aves ERBB2IP 35
  • 78.62 (n)
  • 80.19 (a)
  • 74 (a)
(Anolis carolinensis)
Reptilia ERBB2IP 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia erbb2ip 35
  • 71.15 (n)
  • 73.17 (a)
(Danio rerio)
Actinopterygii erbb2ip 35
  • 63 (n)
  • 66.36 (a)
erbb2ip 36
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta Lap1 36
  • 32 (a)
Lap1 37
  • 40 (a)
(Caenorhabditis elegans)
Secernentea let-413 37
  • 39 (a)
Species with no ortholog for ERBB2IP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ERBB2IP Gene

Gene Tree for ERBB2IP (if available)
Gene Tree for ERBB2IP (if available)

Paralogs for ERBB2IP Gene

Selected SIMAP similar genes for ERBB2IP Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ERBB2IP: view

Variants for ERBB2IP Gene

Sequence variations from dbSNP and Humsavar for ERBB2IP Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs27075 -- 66,074,551(-) ATTTT(A/G)TGGTA intron-variant
rs27132 -- 65,992,963(-) TATCA(C/T)ATTTC intron-variant
rs27569 -- 66,077,591(-) AATTA(A/G)TTTTA intron-variant
rs36288 -- 66,030,280(-) cggat(C/T)acctg intron-variant
rs36289 -- 66,030,249(-) gcctg(A/G)ccaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERBB2IP Gene

Variant ID Type Subtype PubMed ID
nsv830327 CNV Gain 17160897
nsv881759 CNV Loss 21882294
esv23411 CNV Loss 19812545
esv2381441 CNV Deletion 18987734
esv2662265 CNV Deletion 23128226
esv29131 CNV Loss 19812545
nsv517132 CNV Loss 19592680
nsv525852 CNV Loss 19592680
nsv518239 CNV Loss 19592680
esv2411305 CNV Deletion 18987734
esv2472252 CNV Deletion 19546169
esv2151663 CNV Deletion 18987734
esv4869 CNV Deletion 18987735
esv2730278 CNV Deletion 23290073
esv1010663 CNV Deletion 20482838
esv7534 CNV Loss 19470904
esv1036921 CNV Deletion 17803354

Relevant External Links for ERBB2IP Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERBB2IP Gene

Disorders for ERBB2IP Gene

(1) Novoseek inferred disease relationships for ERBB2IP Gene

Disease -log(P) Hits PubMed IDs
tumors 0 5

Relevant External Links for ERBB2IP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ERBB2IP: view

No data available for UniProtKB/Swiss-Prot for ERBB2IP Gene

Publications for ERBB2IP Gene

  1. ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor. (PMID: 10878805) Borg J.-P. … Birnbaum D. (Nat. Cell Biol. 2000) 2 3 4 23
  2. The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression. (PMID: 11375975) Favre B. … Borradori L. (J. Biol. Chem. 2001) 3 4 23
  3. The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF. (PMID: 11821434) Laura R.P. … Lasky L.A. (J. Biol. Chem. 2002) 3 4 23
  4. Novel mode of ligand recognition by the Erbin PDZ domain. (PMID: 12444095) Birrane G. … Ladias J.A. (J. Biol. Chem. 2003) 3 4 23
  5. Origins of PDZ domain ligand specificity. Structure determination and mutagenesis of the Erbin PDZ domain. (PMID: 12446668) Skelton N.J. … Sidhu S.S. (J. Biol. Chem. 2003) 3 4 23

Products for ERBB2IP Gene

  • antibodies-online proteins for ERBB2IP
  • antibodies-online antibodies for ERBB2IP
  • antibodies-online kits for ERBB2IP

Sources for ERBB2IP Gene

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