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Aliases for ERBB2 Gene

Aliases for ERBB2 Gene

  • Erb-B2 Receptor Tyrosine Kinase 2 2 3
  • HER2 3 4 6
  • NGL 3 4 6
  • NEU 3 4 6
  • V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 2 3
  • Tyrosine Kinase-Type Cell Surface Receptor HER2 3 4
  • Neuro/Glioblastoma Derived Oncogene Homolog 2 3
  • Human Epidermal Growth Factor Receptor 2 2 3
  • Metastatic Lymph Node Gene 19 Protein 3 4
  • Proto-Oncogene C-ErbB-2 3 4
  • Proto-Oncogene Neu 3 4
  • EC 2.7.10.1 4 64
  • P185erbB2 3 4
  • MLN 19 3 4
  • V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 (Neuro/Glioblastoma Derived Oncogene Homolog) 2
  • V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog 3
  • V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncoprotein 2 3
  • Neuroblastoma/Glioblastoma Derived Oncogene Homolog 3
  • Receptor Tyrosine-Protein Kinase ErbB-2 3
  • C-Erb B2/Neu Protein 3
  • CD340 Antigen 4
  • HER-2/Neu 3
  • Herstatin 3
  • EC 2.7.10 64
  • CD340 3
  • HER-2 3
  • MLN19 4
  • TKR1 3

External Ids for ERBB2 Gene

Previous Symbols for ERBB2 Gene

  • NGL

Summaries for ERBB2 Gene

Entrez Gene Summary for ERBB2 Gene

  • This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for ERBB2 Gene

ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with ERBB2 include breast scirrhous carcinoma and lipid-rich carcinoma. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include identical protein binding and protein C-terminus binding. An important paralog of this gene is TNK1.

UniProtKB/Swiss-Prot for ERBB2 Gene

  • Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization

  • In the nucleus is involved in transcriptional regulation. Associates with the 5-TCAAATTC-3 sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth

Tocris Summary for ERBB2 Gene

  • The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4). EGFR signaling is initiated by ligand binding to the extracellular ligand binding domain. This initiates receptor homo-/hetero-dimerization and autophosphorylation by the intracellular kinase domain, resulting in receptor activation. Following activation, phosphorylation of cytoplasmic substrates occurs and a signaling cascade is initiated that drives many cellular responses, including changes in gene expression, cytoskeletal rearrangement, anti-apoptosis and increased cell proliferation.

Gene Wiki entry for ERBB2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERBB2 Gene

Genomics for ERBB2 Gene

Genomic Location for ERBB2 Gene

Start:
39,687,914 bp from pter
End:
39,730,426 bp from pter
Size:
42,513 bases
Orientation:
Plus strand

Genomic View for ERBB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ERBB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERBB2 Gene

Regulatory Elements for ERBB2 Gene

Proteins for ERBB2 Gene

  • Protein details for ERBB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04626-ERBB2_HUMAN
    Recommended name:
    Receptor tyrosine-protein kinase erbB-2
    Protein Accession:
    P04626
    Secondary Accessions:
    • B2RZG3
    • B4DHN3
    • Q14256
    • Q6LDV1
    • Q9UMK4
    • X5D2V5

    Protein attributes for ERBB2 Gene

    Size:
    1255 amino acids
    Molecular mass:
    137910 Da
    Quaternary structure:
    • Homodimer. Heterodimer with EGFR, ERBB3 and ERBB4. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with PRKCABP and PLXNB1. Interacts (when phosphorylated on Tyr-1248) with MEMO1. Interacts with MUC1; the interaction is enhanced by heregulin (HRG). Interacts (when phosphorylated on Tyr-1139) with GRB7 (via SH2 domain). Interacts (when phosphorylated on Tyr-1248) with ERBB2IP. Interacts with KPNB1, RANBP2, EEA1, CRM1, CLTC, PTK6, RPA94 and ACTB. Interacts with SRC and MYOC (By similarity).

    Three dimensional structures from OCA and Proteopedia for ERBB2 Gene

    Alternative splice isoforms for ERBB2 Gene

neXtProt entry for ERBB2 Gene

Proteomics data for ERBB2 Gene at MOPED

Post-translational modifications for ERBB2 Gene

  • Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Signaling via SEMA4C promotes phosphorylation at Tyr-1248.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys724, Lys736, Lys747, Lys753, and Lys860
  • Glycosylation at Asn68, Asn124, Asn187, Asn259, Asn530, Asn571, and Asn629

Domains for ERBB2 Gene

UniProtKB/Swiss-Prot:

ERBB2_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • P04626
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.:
    • P04626
genes like me logo Genes that share domains with ERBB2: view

Function for ERBB2 Gene

Molecular function for ERBB2 Gene

GENATLAS Biochemistry: avian erythroblastic leukemia viral (v-erb-b) oncogene homolog 2,HERC2/neu receptor tyrosine kinase,neuroglioblastoma derived,constitutively acting as a coreceptor for multiple stroma-derived growth factors i.e EGF-like ligands and neuregulins after heterodimerization with other ERBBs,involved in androgen receptor transactivation of inducing prostate-specific antigen (PSA) through the MAP kinase pathway,signal transducer,also presenting as a secreted transcript herstatin,expressed in normal fetal kidney and liver,potential inhibitor of ERBB2,commonly amplified in primary breast cancer and in endometrial cancer,coamplified with GRB7 in primary gastric cancer,and in prostate carcinoma with metastasis and poor prognosis
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by dimerization. Not activated by EGF, TGF-alpha and amphiregulin. Interaction with PTK6 increases its intrinsic kinase activity.
UniProtKB/Swiss-Prot Function: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization
UniProtKB/Swiss-Prot Function: In the nucleus is involved in transcriptional regulation. Associates with the 5-TCAAATTC-3 sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth

Enzyme Numbers (IUBMB) for ERBB2 Gene

Gene Ontology (GO) - Molecular Function for ERBB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001042 RNA polymerase I core binding IDA 21555369
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IDA 7514177
GO:0004716 receptor signaling protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with ERBB2: view
genes like me logo Genes that share phenotypes with ERBB2: view

Animal Models for ERBB2 Gene

MGI Knock Outs for ERBB2:

No data available for Transcription Factor Targeting and HOMER Transcription for ERBB2 Gene

Localization for ERBB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERBB2 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1.
Isoform 2: Cytoplasm. Nucleus.
Isoform 3: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ERBB2 Gene COMPARTMENTS Subcellular localization image for ERBB2 gene
Compartment Confidence
endosome 5
nucleus 5
plasma membrane 5
cytoskeleton 3
extracellular 3
cytosol 2
endoplasmic reticulum 2
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ERBB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane TAS --
GO:0010008 endosome membrane IDA 16314522
GO:0016020 membrane --
genes like me logo Genes that share ontologies with ERBB2: view

Pathways for ERBB2 Gene

genes like me logo Genes that share pathways with ERBB2: view

Gene Ontology (GO) - Biological Process for ERBB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006468 protein phosphorylation TAS 10851066
GO:0007165 signal transduction IDA 10572067
GO:0007166 cell surface receptor signaling pathway IDA 9685399
genes like me logo Genes that share ontologies with ERBB2: view

Compounds for ERBB2 Gene

(5) Tocris Compounds for ERBB2 Gene

Compound Action Cas Number
AG 1478 hydrochloride Highly potent EGFR-kinase inhibitor [153436-53-4]
AG 490 EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor [133550-30-8]
Genistein EGFR kinase inhibitor. Also estrogen and PPARgamma ligand [446-72-0]
Iressa Orally active, selective EGFR inhibitor [184475-35-2]
JNJ 28871063 hydrochloride Potent ErbB receptor family inhibitor [944341-54-2]

(2) HMDB Compounds for ERBB2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(5) Drugbank Compounds for ERBB2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
ado-trastuzumab emtansine
  • RG-3502
1018448-65- target antibody
Afatinib
850140-72-6 target inhibitor
Lapatinib
  • FMM
388082-78-8 target antagonist
Pertuzumab
  • 2C4 Antibody
380610-27-5 target antibody
Trastuzumab
  • Anti HER2
180288-69-1 target antibody

(125) Novoseek inferred chemical compound relationships for ERBB2 Gene

Compound -log(P) Hits PubMed IDs
trastuzumab 97.1 401
lapatinib 91.7 158
estrogen 88.7 261
progesterone 87.8 229
cb 11 87.4 67

(5) PharmGKB related drug/compound annotations for ERBB2 Gene

genes like me logo Genes that share compounds with ERBB2: view

Transcripts for ERBB2 Gene

Unigene Clusters for ERBB2 Gene

V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ERBB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - -
SP2: -
SP3: -
SP4: -
SP5:
SP6:

ExUns: 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27a · 27b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -

Relevant External Links for ERBB2 Gene

GeneLoc Exon Structure for
ERBB2
ECgene alternative splicing isoforms for
ERBB2

Expression for ERBB2 Gene

mRNA expression in normal human tissues for ERBB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ERBB2 Gene

SOURCE GeneReport for Unigene cluster for ERBB2 Gene Hs.446352

mRNA Expression by UniProt/SwissProt for ERBB2 Gene

P04626-ERBB2_HUMAN
Tissue specificity: Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.
genes like me logo Genes that share expressions with ERBB2: view

Orthologs for ERBB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ERBB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ERBB2 36
  • 99.55 (n)
  • 99.76 (a)
ERBB2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ERBB2 36
  • 90.31 (n)
  • 92.19 (a)
ERBB2 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ERBB2 36
  • 90.78 (n)
  • 92.66 (a)
ERBB2 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Erbb2 36
  • 85.6 (n)
  • 87.73 (a)
Erbb2 16
Erbb2 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ERBB2 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ERBB2 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Erbb2 36
  • 85.9 (n)
  • 88.13 (a)
chicken
(Gallus gallus)
Aves ERBB2 36
  • 72.97 (n)
  • 71.76 (a)
ERBB2 37
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ERBB2 37
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14390 36
tropical clawed frog
(Silurana tropicalis)
Amphibia erbb2 36
  • 63.17 (n)
  • 62.53 (a)
zebrafish
(Danio rerio)
Actinopterygii erbb2 36
  • 60.77 (n)
  • 59.31 (a)
erbb2 37
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Egfr 38
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea let-23 38
  • 34 (a)
Species with no ortholog for ERBB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ERBB2 Gene

ENSEMBL:
Gene Tree for ERBB2 (if available)
TreeFam:
Gene Tree for ERBB2 (if available)

Paralogs for ERBB2 Gene

Paralogs for ERBB2 Gene

genes like me logo Genes that share paralogs with ERBB2: view

Variants for ERBB2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ERBB2 Gene

P04626-ERBB2_HUMAN
There are four alleles due to the variations in positions 654 and 655. Allele B1 (Ile-654/Ile-655) has a frequency of 0.782; allele B2 (Ile-654/Val-655) has a frequency of 0.206; allele B3 (Val-654/Val-655) has a frequency of 0.012

Sequence variations from dbSNP and Humsavar for ERBB2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs169244 -- 39,701,289(+) TCCTA(A/G)AACAC intron-variant
rs272159 -- 39,722,873(+) accac(A/G)cccag intron-variant
rs387082 -- 39,706,746(+) CAGCC(A/C/G/T)CTGAA intron-variant, upstream-variant-2KB
rs445358 -- 39,706,745(-) TCAGN(A/G)GCTGC intron-variant, upstream-variant-2KB
rs903506 -- 39,723,509(+) CCCCC(A/G)GCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERBB2 Gene

Variant ID Type Subtype PubMed ID
dgv40n68 CNV Loss 17160897
dgv3162n71 CNV Loss 21882294
nsv908207 CNV Loss 21882294
nsv528093 CNV Loss 19592680
nsv908214 CNV Loss 21882294
esv274928 CNV Gain+Loss 21479260
dgv3165n71 CNV Gain 21882294
nsv2048 CNV Insertion 18451855
esv275276 CNV Loss 21479260
nsv908219 CNV Loss 21882294

Relevant External Links for ERBB2 Gene

HapMap Linkage Disequilibrium report
ERBB2
Human Gene Mutation Database (HGMD)
ERBB2

Disorders for ERBB2 Gene

(3) OMIM Diseases for ERBB2 Gene (164870)

UniProtKB/Swiss-Prot

ERBB2_HUMAN
  • Hereditary diffuse gastric cancer (HDGC) [MIM:137215]: A cancer predisposition syndrome with increased susceptibility to diffuse gastric cancer. Diffuse gastric cancer is a malignant disease characterized by poorly differentiated infiltrating lesions resulting in thickening of the stomach. Malignant tumors start in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. Note=The gene represented in this entry is involved in disease pathogenesis.
  • Glioma (GLM) [MIM:137800]: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. Note=The gene represented in this entry is involved in disease pathogenesis.
  • Ovarian cancer (OC) [MIM:167000]: The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. Note=The gene represented in this entry is involved in disease pathogenesis.
  • Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. Note=The gene represented in this entry is involved in disease pathogenesis.
  • Note=Chromosomal aberrations involving ERBB2 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with CDK12, leading to CDK12-ERBB2 fusion leading to truncated CDK12 protein not in-frame with ERBB2.

(96) Novoseek inferred disease relationships for ERBB2 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 94.7 497
breast carcinoma 92.4 309
carcinoma ductal 89.4 147
tumors 88.5 475
breast cancer metastatic 88.3 180

Relevant External Links for ERBB2

Genetic Association Database (GAD)
ERBB2
Human Genome Epidemiology (HuGE) Navigator
ERBB2
Tumor Gene Database (TGDB):
ERBB2
genes like me logo Genes that share disorders with ERBB2: view

Publications for ERBB2 Gene

  1. Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. (PMID: 10805725) Arcaro A. … Domin J. (Mol. Cell. Biol. 2000) 3 4 23
  2. No association between HER-2 gene polymorphism at codon 655 and a risk of bladder cancer. (PMID: 11857355) Wang L. … Kato T. (Int. J. Cancer 2002) 3 23 49
  3. Ethnic variation in the HER-2 codon 655 genetic polymorphism previously associated with breast cancer. (PMID: 12166652) Ameyaw M.M. … McLead H.L. (J. Hum. Genet. 2002) 3 23 49
  4. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. (PMID: 12610629) Cho H.-S. … Leahy D.J. (Nature 2003) 3 4 23
  5. A single nucleotide polymorphism in the transmembrane domain coding region of HER-2 is associated with development and malignant phenotype of gastric cancer. (PMID: 14520697) Kuraoka K. … Yasui W. (Int. J. Cancer 2003) 3 23 49

Products for ERBB2 Gene

  • Addgene plasmids for ERBB2

Sources for ERBB2 Gene

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