ERBB2 Gene
protein-coding GIFtS : 80 GCID: GC17 P037844
v-erb-b2 erythroblastic leukemia viral oncogene homolog... v-erb-b2 avian erythroblastic leukemia viral oncogene homolog... NGL )
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Aliasesfor ERBB2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2,Neuro/Glioblastoma Derived Oncogene Homolog (Avian) 1 2 P185erbB21 HER21 2 3 5 EC 2.7.10.13 8 NEU1 2 3 5 HER-2/Neu1 NGL1 2 3 5 TKR12 CD3401 2 C-Erb B2/Neu Protein2 HER-21 2 Herstatin1 V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2(Neuro/Glioblastoma Derived Oncogene Homolog)1 2 Neuroblastoma/Glioblastoma Derived Oncogene Homolog2 Metastatic Lymph Node Gene 19 Protein2 3 Receptor Tyrosine-Protein Kinase ErbB-22 Proto-Oncogene C-ErbB-22 3 MLN193 Proto-Oncogene Neu2 3 CD340 Antigen3 Tyrosine Kinase-Type Cell Surface Receptor HER22 3 EC 2.7.108 MLN 192 3
Export aliases for ERBB2 gene to outside databases Previous GC identifers: GC17P037262 GC17P039854 GC17P037766 GC17P038231 GC17P035109 GC17P033638
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Summariesfor ERBB2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ERBB2 : This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: ERBB2_HUMAN, P04626 Function : Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs acoreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization Function : In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in thePTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth summary
for ERBB2 : The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four membersof the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4).EGFR signaling is initiated by ligand binding to the extracellular ligand binding domain. This initiatesreceptor homo-/hetero-dimerization and autophosphorylation by the intracellular kinase domain, resulting inreceptor activation. Following activation, phosphorylation of cytoplasmic substrates occurs and a signalingcascade is initiated that drives many cellular responses, including changes in gene expression, cytoskeletalrearrangement, anti-apoptosis and increased cell proliferation. Gene Wiki entry for ERBB2 (HER2/neu)
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Genomic Viewsfor ERBB2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000017.10 NC_018928.1 NT_010783.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ERBB2 gene promoter:AP-2alpha isoform 3 AP-2alpha isoform 4 AP-2alpha isoform 2 AP-2alpha AP-2alphaA Other transcription factors Search SABiosciences Chromatin IP Primers for ERBB2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 17q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q11.2-q12 ERBB2 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17P037844: view genomic region
(about GC identifiers )
Start: 37,844,167 bp from pter End:
37,886,679 bp from pter
Size: 42,513 bases Orientation:
plus strand
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Proteinsfor ERBB2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ERBB2_HUMAN, P04626 See
protein sequence )Recommended Name: Size : 1255 amino acids; 137910 DaSubunit : Homodimer. Heterodimer with EGFR, ERBB3 and ERBB4. Part of a complex with EGFR and either PIK3C2A or PIK3C2B.May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with PRKCABP and PLXNB1. Interacts (when phosphorylated on Tyr-1248) with MEMO1. Interacts with MUC1; the interaction is enhanced by heregulin (HRG). Interacts (when phosphorylated on Tyr-1139) with GRB7 (via SH2 domain). Interacts (when phosphorylated on Tyr-1248) with ERBB2IP. Interacts with KPNB1, RANBP2, EEA1, CRM1, CLTC, PTK6, RPA94 and ACTB. Interacts with SRC (By similarity)
Subcellular location : Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region.Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1
Subcellular location : Isoform 2: Cytoplasm. NucleusSubcellular location : Isoform 3: Cytoplasm. Nucleus6/17 PDB 3D structures from (see all 17 ):1MFG (3D) 1MFL (3D) 1MW4 (3D) 1N8Z (3D) 1OVC (3D) 1QR1 (3D) Secondary accessions : B2RZG3 B4DHN3 Q14256 Q6LDV1 Q9UMK4Alternative splicing, Alternative initiation : 4 isoforms : P04626-1 P04626-2 P04626-3 P04626-4 (Produced by alternative splicing of isoform 1)Explore the universe of human proteins at neXtProt for ERBB2: NX_P04626 Post-translational modifications:
Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Signaling via SEMA4C promotes phosphorylation at Tyr-12481
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P04626 4/35 DME Specific Peptides for ERBB2 (P04626 ) (see all 35 )ERBB2 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (2 alternative transcripts): NP_001005862.1 NP_004439.2 ENSEMBL proteins: ENSP00000462438 ENSP00000462808 ENSP00000404047 ENSP00000463714 ENSP00000462024 ENSP00000269571 ENSP00000463427 ENSP00000463719 ENSP00000462270 ENSP00000464420 ENSP00000464252 ENSP00000463002 ENSP00000446466 ENSP00000385185 ENSP00000443562 ENSP00000446382 Reactome Protein details: P04626 Human Recombinant Protein Products for ERBB2: Gene Ontology (GO): 5/15 cellular component terms (GO ID links to tree view) (see all 15 ): About this table
About GeneDecksing ERBB2 Antibody Products: Assay Products for ERBB2:
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Protein
Domains /for ERBB2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/11 InterPro domains/families (see all 11 ):
Graphical View of Domain Structure for InterPro Entry P04626 ProtoNet protein and cluster: P04626
5 Blocks protein families : IPB000494 IPB004019 IPB006211 IPB006212 IPB008266 UniProtKB/Swiss-Prot: ERBB2_HUMAN, P04626 Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamilySimilarity : Contains 1 protein kinase domain
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Functionfor ERBB2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: ERBB2_HUMAN, P04626 Function : Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs acoreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization Function : In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in thePTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth Catalytic activity : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphateEnzyme regulation : Activated by dimerization. Not activated by EGF, TGF-alpha and amphiregulin. Interaction with PTK6increases its intrinsic kinase activity
Genatlas biochemistry entry for ERBB2 avian erythroblastic leukemia viral (v-erb-b) oncogene homolog 2,HERC2/neu receptor tyrosine kinase,neuroglioblastoma derived,constitutively acting as a coreceptor for multiple stroma-derived growth factors i.e EGF-like ligands and neuregulins after heterodimerization with other ERBBs,involved in androgen receptor transactivation of inducing prostate-specific antigen (PSA) through the MAP kinase pathway,signal transducer,also presenting as a secreted transcript herstatin,expressed in normal fetal kidney and liver,potential inhibitor of ERBB2,commonly amplified in primary breast cancer and in endometrial cancer,coamplified with GRB7 in primary gastric cancer,and in prostate carcinoma with metastasis and poor prognosis Enzyme Numbers (IUBMB): EC 2.7.10.1 1 2 EC 2.7.10 2 Gene Ontology (GO): 5/19 molecular function terms (GO ID links to tree view) (see all 19 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0001042 RNA polymerase I core binding
IDA -- GO:0001948 glycoprotein binding
-- -- GO:0004713 protein tyrosine kinase activity
TAS -- GO:0004714 transmembrane receptor protein tyrosine kinase activity
IDA 7514177 GO:0004716 receptor signaling protein tyrosine kinase activity
IEA --
About GeneDecksing Phenotypes: 2 GenomeRNAi human phenotypes for ERBB2 :15/19 MGI mutant phenotypes (inferred from 17 alleles(MGI details for Erbb2) (see all 19 ):About GeneDecksing Animal Models: Erbb2 tm1Vrtn Erbb2 tm1Gne Erbb2 tm2Mul Erbb2 tm1Haus Erbb2 tm2.1Cbm Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 6 )human mouse rat see all 4 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): ERBB2 (NM_004448 ) Sino Biological Human cDNA Clone for ERBB2 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ERBB2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ERBB2
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERBB2
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Pathways & Interactionsfor ERBB2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/54 super-pathways (see all 54 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Signaling by FGFR 2 PIP3 activates AKT signaling 3 GPCR Pathway 4 Development HGF signaling pathway 5 Rho Family GTPases
Pathway sources See GeneCards unified pathways Show all pathways 5/8 (see all 8 )5/38 (see all 38 )1 4 5/8 (see all 8 )5/15 (see all 15 ) 5/39 (see all 39 )1 ERBB2 5/10 (Kegg details for ERBB2) (see all 10 ):About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ERBB2 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)206/226 Interacting proteins for ERBB2 (P04626 1 , 2 , 3 ENSP00000269571 4 via UniProtKB, MINT, STRING , and/or I2D (see all 226 ) (see top 5 )Interactant Interaction Details GeneCard External ID(s) SHC1 P29353 2 , 3 ENSP00000401303 4 MINT-61510 MINT-61506 MINT-74737 MINT-61504 MINT-74734 MINT-74736 MINT-61508 MINT-74733 MINT-74735 MINT-61511 I2D:
score=8 STRING: ENSP00000401303 PIK3R3 Q92569 2 , 3 ENSP00000262741 4 MINT-74664 MINT-74642 MINT-74650 MINT-74662 MINT-74660 MINT-74649 MINT-74663 MINT-74641 MINT-74661 I2D:
score=2 STRING: ENSP00000262741 PIK3R2 O00459 2 , 3 ENSP00000222254 4 MINT-74622 MINT-74623 MINT-74620 MINT-74631 MINT-74621 MINT-61505 MINT-74632 I2D:
score=5 STRING: ENSP00000222254 SYK P43405 2 , 3 ENSP00000364898 4 MINT-74765 MINT-74767 MINT-74769 MINT-74758 MINT-74768 MINT-74764 MINT-74766 I2D:
score=2 STRING: ENSP00000364898 ABL2 P42684 2 , 3 ENSP00000356595 4 MINT-74443 MINT-74440 MINT-74444 MINT-74442 MINT-74439 MINT-74441 I2D:
score=2 STRING: ENSP00000356595 GRB7 Q14451 2 , 3 ENSP00000310771 4 MINT-8026387 MINT-8026402 MINT-74543 MINT-74544 MINT-8026346 I2D:
score=5 STRING: ENSP00000310771 PLCG1 P19174 2 , 3 ENSP00000244007 4 MINT-74674 MINT-74677 MINT-74679 MINT-74673 MINT-74680 I2D:
score=5 STRING: ENSP00000244007 TENC1 Q63HR2 2 , 3 ENSP00000319756 4 MINT-74780 MINT-74778 MINT-74781 MINT-74779 I2D:
score=2 STRING: ENSP00000319756 CISH Q9NSE2 2 , 3 ENSP00000409346 4 MINT-74493 MINT-74492 MINT-74494 MINT-74495 I2D:
score=1 STRING: ENSP00000409346 FGR P09769 2 , 3 ENSP00000363115 4 MINT-74537 MINT-74536 MINT-74538 I2D:
score=2 STRING: ENSP00000363115 VAV2 P52735 2 , 3 ENSP00000360916 4 MINT-74801 MINT-74800 MINT-74802 I2D:
score=2 STRING: ENSP00000360916 TLN1 Q9Y490 2 , 3 ENSP00000316029 4 MINT-74792 MINT-74793 MINT-74791 I2D:
score=1 STRING: ENSP00000316029 GRB2 P62993 2 , 3 ENSP00000339007 4 MINT-61507 MINT-74542 I2D:
score=6 STRING: ENSP00000339007 ABL1 P00519 2 , 3 ENSP00000361423 4 MINT-74429 MINT-74428 I2D:
score=2 STRING: ENSP00000361423 ANKS1A Q92625 2 , 3 ENSP00000353518 4 MINT-74462 MINT-74461 I2D:
score=2 STRING: ENSP00000353518 CRKL P46109 2 , 3 ENSP00000346300 4 MINT-74502 MINT-74501 I2D:
score=2 STRING: ENSP00000346300 DOK1 Q99704 2 , 3 ENSP00000233668 4 MINT-74511 MINT-74512 I2D:
score=2 STRING: ENSP00000233668 JAK1 P23458 2 , 3 ENSP00000343204 4 MINT-74561 MINT-74560 I2D:
score=2 STRING: ENSP00000343204 PLCG2 P16885 2 , 3 ENSP00000352336 4 MINT-74684 MINT-74686 I2D:
score=2 STRING: ENSP00000352336 SLA2 Q9H6Q3 2 , 3 ENSP00000262866 4 MINT-74748 MINT-74749 I2D:
score=2 STRING: ENSP00000262866 STAT1 P42224 2 , 3 ENSP00000354394 4 MINT-74754 MINT-74755 I2D:
score=2 STRING: ENSP00000354394 TNS3 Q68CZ2 2 , 3 ENSP00000312143 4 MINT-74785 MINT-74786 I2D:
score=2 STRING: ENSP00000312143 APBB1 O00213 2 , 3 ENSP00000299402 4 MINT-74467 MINT-74470 I2D:
score=1 STRING: ENSP00000299402 CLNK Q7Z7G1 2 , 3 ENSP00000226951 4 MINT-74585 MINT-74586 I2D:
score=1 STRING: ENSP00000226951 SUPT6H Q7KZ85 2 , 3 ENSP00000319104 4 MINT-74520 MINT-74521 I2D:
score=1 STRING: ENSP00000319104 MATK P42679 2 , 3 MINT-8038609 MINT-74582 I2D:
score=4 PIK3C2B O00750 1 , 3 ENSP00000356155 4 EBI-641062,EBI-641107 I2D:
score=3 STRING: ENSP00000356155 BLK P51451 2 , 3 ENSP00000259089 4 MINT-74485 I2D:
score=2 STRING: ENSP00000259089 BLNK Q8WV28 2 , 3 ENSP00000224337 4 MINT-74486 I2D:
score=2 STRING: ENSP00000224337 CRK P46108 2 , 3 ENSP00000300574 4 MINT-74498 I2D:
score=2 STRING: ENSP00000300574 DAB1 O75553 2 , 3 ENSP00000360277 4 MINT-74508 I2D:
score=2 STRING: ENSP00000360277 SH3BP2 P78314 2 , 3 ENSP00000348685 4 MINT-74724 I2D:
score=2 STRING: ENSP00000348685 TEC P42680 2 , 3 ENSP00000370912 4 MINT-74777 I2D:
score=2 STRING: ENSP00000370912 VAV3 Q9UKW4 2 , 3 ENSP00000359073 4 MINT-74804 I2D:
score=2 STRING: ENSP00000359073 CHN1 P15882 2 , 3 ENSP00000386741 4 MINT-74489 I2D:
score=1 STRING: ENSP00000386741 CSK P41240 2 , 3 ENSP00000220003 4 MINT-8038594 I2D:
score=1 STRING: ENSP00000220003 FER P16591 2 , 3 ENSP00000281092 4 MINT-74533 I2D:
score=1 STRING: ENSP00000281092 PTPRK Q15262 1 , 3 ENSP00000357209 4 EBI-641062,EBI-474052 I2D:
score=1 STRING: ENSP00000357209 PTPRO Q16827 1 , 3 ENSP00000281171 4 EBI-641062,EBI-723739 I2D:
score=1 STRING: ENSP00000281171 RIN1 Q13671 2 , 3 ENSP00000310406 4 MINT-74713 I2D:
score=1 STRING: ENSP00000310406 SH2B3 Q9UQQ2 2 , 3 ENSP00000345492 4 MINT-74567 I2D:
score=1 STRING: ENSP00000345492 SH2D5 Q6ZV89 2 , 3 ENSP00000408509 4 MINT-74528 I2D:
score=1 STRING: ENSP00000408509 SH3BGRL3 Q9H299 2 , 3 MINT-61509 I2D:
score=3 ANKS1B Q7Z6G8 2 , 3 MINT-74531 I2D:
score=2 APBB3 O95704 2 , 3 MINT-74477 I2D:
score=2 DOK6 Q6PKX4 2 , 3 MINT-74519 I2D:
score=2 RASA1 P20936 2 , 3 ENSP00000274376 4 MINT-74698 MINT-74702 MINT-74697 MINT-74701 MINT-74699 MINT-74712 MINT-74700 I2D:
score=2 STRING: ENSP00000274376 MEMO1 Q9Y316 2 , 3 ENSP00000295065 4 MINT-8202763 MINT-8202727 MINT-8202780 MINT-8202797 MINT-8202814 MINT-8202835 I2D:
score=1 STRING: ENSP00000295065 PIK3R1 P27986 2 , 3 ENSP00000274335 4 MINT-74609 MINT-74599 MINT-74607 MINT-74610 MINT-74608 I2D:
score=5 STRING: ENSP00000274335 RECK O95980 2 , 3 ENSP00000367202 4 MINT-8085378 MINT-8085327 MINT-8085341 MINT-8085361 I2D:
score=1 STRING: ENSP00000367202 STAT3 P40763 2 , 3 ENSP00000264657 4 MINT-74756 MINT-8025768 MINT-8026372 I2D:
score=2 STRING: ENSP00000264657 ACPP P15309 2 , 3 ENSP00000323036 4 MINT-8255912 MINT-8212366 MINT-8255748 I2D:
score=2 STRING: ENSP00000323036 MAPK8IP1 Q9UQF2 2 , 3 ENSP00000241014 4 MINT-74574 MINT-74575 MINT-74573 I2D:
score=2 STRING: ENSP00000241014 MAPK8IP2 Q13387 2 , 3 ENSP00000330572 4 MINT-74580 MINT-74581 MINT-74579 I2D:
score=2 STRING: ENSP00000330572 SHC2 P98077 2 , 3 ENSP00000264554 4 MINT-74526 MINT-74527 MINT-74525 I2D:
score=1 STRING: ENSP00000264554 EGFR P00533 1 , 2 , 3 ENSP00000275493 4 EBI-641062,EBI-297353 MINT-1788719 I2D:
score=5 STRING: ENSP00000275493 SRC P12931 1 , 2 , 3 ENSP00000350941 4 EBI-641062,EBI-1383910 MINT-8026361 I2D:
score=6 STRING: ENSP00000350941 PTPN11 Q06124 2 , 3 ENSP00000340944 4 MINT-74690 MINT-74691 I2D:
score=5 STRING: ENSP00000340944 SOCS1 O15524 2 , 3 ENSP00000329418 4 MINT-74751 MINT-74750 I2D:
score=2 STRING: ENSP00000329418 SHC3 Q92529 2 , 3 ENSP00000364995 4 MINT-74742 MINT-74743 I2D:
score=2 STRING: ENSP00000364995 NCK2 O43639 2 , 3 ENSP00000233154 4 MINT-74589 MINT-74590 I2D:
score=2 STRING: ENSP00000233154 DOK4 Q8TEW6 2 , 3 ENSP00000344277 4 MINT-74514 MINT-74515 I2D:
score=2 STRING: ENSP00000344277 IRS1 P35568 2 , 3 ENSP00000304895 4 MINT-74552 MINT-74553 I2D:
score=2 STRING: ENSP00000304895 ITK Q08881 2 , 3 ENSP00000398655 4 MINT-74558 MINT-74557 I2D:
score=2 STRING: ENSP00000398655 SH2D2A Q9NP31 2 , 3 ENSP00000357182 4 MINT-74721 MINT-74722 I2D:
score=2 STRING: ENSP00000357182 HLA-A P04439 3 ENSP00000366005 4 I2D:
score=1 I2D:
score=1 STRING: ENSP00000366005 ERBB3 P21860 1 , 3 ENSP00000267101 4 EBI-641062,EBI-720706 I2D:
score=7 STRING: ENSP00000267101 ERBB4 Q15303 1 , 3 ENSP00000342235 4 EBI-641062,EBI-80371 I2D:
score=4 STRING: ENSP00000342235 PTPN12 Q05209 1 , 3 ENSP00000248594 4 EBI-641062,EBI-2266035 I2D:
score=1 STRING: ENSP00000248594 GRAP2 O75791 2 , 3 ENSP00000339186 4 MINT-74540 I2D:
score=2 STRING: ENSP00000339186 SH2B2 O14492 2 , 3 ENSP00000304701 4 MINT-74480 I2D:
score=2 STRING: ENSP00000304701 SH2D1B O14796 2 , 3 ENSP00000356906 4 MINT-74529 I2D:
score=2 STRING: ENSP00000356906 SH2D3A Q9BRG2 2 , 3 ENSP00000245908 4 MINT-74723 I2D:
score=2 STRING: ENSP00000245908 PTPRB P23467 1 , 3 ENSP00000334928 4 EBI-641062,EBI-1265766 I2D:
score=1 STRING: ENSP00000334928 PTPRC P08575 1 , 3 ENSP00000356346 4 EBI-641062,EBI-1341 I2D:
score=1 STRING: ENSP00000356346 PTPRJ Q12913 1 , 3 ENSP00000400010 4 EBI-641062,EBI-2264500 I2D:
score=1 STRING: ENSP00000400010 BMX P51813 2 , 3 ENSP00000308774 4 MINT-74488 I2D:
score=2 STRING: ENSP00000308774 RIN2 Q8WYP3 2 , 3 ENSP00000255006 4 MINT-74716 I2D:
score=2 STRING: ENSP00000255006 SLA Q13239 2 , 3 ENSP00000394049 4 MINT-74747 I2D:
score=1 STRING: ENSP00000394049 TXK P42681 2 , 3 ENSP00000264316 4 MINT-74794 I2D:
score=2 STRING: ENSP00000264316 IRS4 O14654 2 , 3 ENSP00000361202 4 MINT-74556 I2D:
score=1 STRING: ENSP00000361202 ERBB2IP Q96RT1 3 ENSP00000370330 4 I2D:
score=5 STRING: ENSP00000370330 JUP P14923 3 ENSP00000311113 4 I2D:
score=4 STRING: ENSP00000311113 IL6ST P40189 3 ENSP00000338799 4 I2D:
score=3 STRING: ENSP00000338799 PAK1 Q13153 3 ENSP00000278568 4 I2D:
score=3 STRING: ENSP00000278568 PTK2B Q14289 3 ENSP00000332816 4 I2D:
score=3 STRING: ENSP00000332816 DLG4 P78352 3 ENSP00000293813 4 I2D:
score=2 STRING: ENSP00000293813 MUC1 P15941 3 ENSP00000338983 4 I2D:
score=2 STRING: ENSP00000338983 NF2 P35240 3 ENSP00000344666 4 I2D:
score=2 STRING: ENSP00000344666 PTPN18 Q99952 3 ENSP00000175756 4 I2D:
score=2 STRING: ENSP00000175756 TOB1 P50616 3 ENSP00000268957 4 I2D:
score=2 STRING: ENSP00000268957 UBB P0CG47 3 ENSP00000304697 4 I2D:
score=2 STRING: ENSP00000304697 BCAR3 O75815 3 ENSP00000260502 4 I2D:
score=1 STRING: ENSP00000260502 ELF3 P78545 3 ENSP00000352673 4 I2D:
score=1 STRING: ENSP00000352673 HDAC6 Q9UBN7 3 ENSP00000334061 4 I2D:
score=1 STRING: ENSP00000334061 ITGB4 P16144 3 ENSP00000200181 4 I2D:
score=1 STRING: ENSP00000200181 MUC4 Q99102 3 ENSP00000304207 4 I2D:
score=1 STRING: ENSP00000304207 NRG1 Q02297 3 ENSP00000349275 4 I2D:
score=1 STRING: ENSP00000349275 PTPN22 Q9Y2R2 3 ENSP00000352833 4 I2D:
score=1 STRING: ENSP00000352833 PTPN3 P26045 3 ENSP00000262539 4 I2D:
score=1 STRING: ENSP00000262539 SHC4 Q6S5L8 3 ENSP00000329668 4 I2D:
score=1 STRING: ENSP00000329668 VAV1 P15498 3 ENSP00000302269 4 I2D:
score=1 STRING: ENSP00000302269 HSP90AA1 P07900 3 ENSP00000335153 4 I2D:
score=3 STRING: ENSP00000335153 UBC P0CG48 3 ENSP00000344818 4 I2D:
score=1 STRING: ENSP00000344818 STUB1 Q9UNE7 3 ENSP00000219548 4 I2D:
score=2 STRING: ENSP00000219548 CTNNB1 P35222 3 ENSP00000344456 4 I2D:
score=4 STRING: ENSP00000344456 HSPA4 P34932 3 ENSP00000302961 4 I2D:
score=1 STRING: ENSP00000302961 PTK2 Q05397 3 ENSP00000341189 4 I2D:
score=2 STRING: ENSP00000341189 CD44 P16070 3 ENSP00000278385 4 I2D:
score=2 STRING: ENSP00000278385 CAV1 Q03135 3 ENSP00000339191 4 I2D:
score=2 STRING: ENSP00000339191 CD82 P27701 3 ENSP00000227155 4 I2D:
score=2 STRING: ENSP00000227155 EGF P01133 3 ENSP00000265171 4 I2D:
score=3 STRING: ENSP00000265171 ERRFI1 Q9UJM3 3 ENSP00000366702 4 I2D:
score=1 STRING: ENSP00000366702 HSP90B1 P14625 3 ENSP00000299767 4 I2D:
score=3 STRING: ENSP00000299767 IQGAP1 P46940 1 ENSP00000268182 4 EBI-641062,EBI-297509 STRING: ENSP00000268182 ITGA5 P08648 3 ENSP00000293379 4 I2D:
score=2 STRING: ENSP00000293379 OSMR Q99650 3 ENSP00000274276 4 I2D:
score=1 STRING: ENSP00000274276 TGFA P01135 3 ENSP00000295400 4 I2D:
score=1 STRING: ENSP00000295400 EEA1 Q15075 1 ENSP00000317955 4 EBI-641062,EBI-298113 STRING: ENSP00000317955 JAK2 O60674 3 ENSP00000371067 4 I2D:
score=4 STRING: ENSP00000371067 LRIG1 Q96JA1 3 ENSP00000273261 4 I2D:
score=1 STRING: ENSP00000273261 PICK1 Q9NRD5 3 ENSP00000349465 4 I2D:
score=3 STRING: ENSP00000349465 PIK3C2A O00443 3 ENSP00000265970 4 I2D:
score=3 STRING: ENSP00000265970 RANBP2 P49792 1 ENSP00000283195 4 EBI-641062,EBI-973138 STRING: ENSP00000283195 ESR1 P03372 3 ENSP00000206249 4 I2D:
score=2 STRING: ENSP00000206249 IGF1R P08069 3 ENSP00000268035 4 I2D:
score=1 STRING: ENSP00000268035 SOS1 Q07889 3 ENSP00000384675 4 I2D:
score=2 STRING: ENSP00000384675 PTPRG P23470 3 ENSP00000418112 4 I2D:
score=1 STRING: ENSP00000418112 PTPRZ1 P23471 3 ENSP00000377047 4 I2D:
score=1 STRING: ENSP00000377047 ACTB P60709 1 ENSP00000349960 4 EBI-641062,EBI-353944 STRING: ENSP00000349960 EFNB1 P98172 1 ENSP00000204961 4 EBI-641062,EBI-538287 STRING: ENSP00000204961 KPNB1 Q14974 1 ENSP00000290158 4 EBI-641062,EBI-286758 STRING: ENSP00000290158 POLR1A O95602 1 ENSP00000263857 4 EBI-641062,EBI-359472 STRING: ENSP00000263857 DOK2 O60496 3 I2D:
score=2 SERPINA3 P01011 3 I2D:
score=2 BTC P35070 3 I2D:
score=1 CDH1 P12830 3 I2D:
score=1 CTNNA1 P35221 3 I2D:
score=1 CUL5 Q93034 3 I2D:
score=1 FRS2 Q8WU20 3 I2D:
score=1 GAB2 Q9UQC2 3 I2D:
score=1 HSPA8 P11142 3 I2D:
score=1 LCK P06239 3 I2D:
score=1 NCK1 P16333 3 I2D:
score=1 NUMBL Q9Y6R0 3 I2D:
score=1 SH3BGRL O75368 3 I2D:
score=1 ERBB2 P04626 1 EBI-641062,EBI-641062 H2AFY O75367 1 EBI-641062,EBI-2868511 HSP90AB1 P08238 1 EBI-641062,EBI-352572 XPO1 O14980 1 EBI-641062,EBI-355867 NEURL ENSP00000358795 4 STRING: ENSP00000358795 ADAM17 ENSP00000309968 4 STRING: ENSP00000309968 ARHGEF12 ENSP00000380942 4 STRING: ENSP00000380942 CDC37 ENSP00000222005 4 STRING: ENSP00000222005 DOCK7 ENSP00000340742 4 STRING: ENSP00000340742 EREG ENSP00000244869 4 STRING: ENSP00000244869 HBEGF ENSP00000230990 4 STRING: ENSP00000230990 HRAS ENSP00000309845 4 STRING: ENSP00000309845 IGHG1 ENSP00000374990 4 STRING: ENSP00000374990 MAP2K1 ENSP00000302486 4 STRING: ENSP00000302486 MAX ENSP00000351490 4 STRING: ENSP00000351490 MYC ENSP00000367207 4 STRING: ENSP00000367207 NRAS ENSP00000358548 4 STRING: ENSP00000358548 NRG2 ENSP00000289422 4 STRING: ENSP00000289422 NRG4 ENSP00000378367 4 STRING: ENSP00000378367 RAC1 ENSP00000348461 4 STRING: ENSP00000348461 RAC2 ENSP00000249071 4 STRING: ENSP00000249071 RHOB ENSP00000272233 4 STRING: ENSP00000272233 RND1 ENSP00000308461 4 STRING: ENSP00000308461 RNF41 ENSP00000342755 4 STRING: ENSP00000342755 SEMA4D ENSP00000343418 4 STRING: ENSP00000343418 UBA52 ENSP00000388107 4 STRING: ENSP00000388107 ARHGEF11 ENSP00000357177 4 STRING: ENSP00000357177 IGKC ENSP00000374777 4 STRING: ENSP00000374777 RHOG ENSP00000339467 4 STRING: ENSP00000339467 ROCK2 ENSP00000317985 4 STRING: ENSP00000317985 CTNND1 ENSP00000382004 4 STRING: ENSP00000382004 FIGF ENSP00000297904 4 STRING: ENSP00000297904 HGF ENSP00000222390 4 STRING: ENSP00000222390 IGF1 ENSP00000302665 4 STRING: ENSP00000302665 MAPK1 ENSP00000215832 4 STRING: ENSP00000215832 MAPK3 ENSP00000263025 4 STRING: ENSP00000263025 PDGFA ENSP00000346508 4 STRING: ENSP00000346508 PDGFB ENSP00000330382 4 STRING: ENSP00000330382 PDGFC ENSP00000274071 4 STRING: ENSP00000274071 PDGFD ENSP00000376865 4 STRING: ENSP00000376865 PGF ENSP00000238607 4 STRING: ENSP00000238607 PIK3CA ENSP00000263967 4 STRING: ENSP00000263967 PIK3CB ENSP00000289153 4 STRING: ENSP00000289153 PIK3CD ENSP00000366563 4 STRING: ENSP00000366563 PIK3CG ENSP00000352121 4 STRING: ENSP00000352121 PIK3R5 ENSP00000269300 4 STRING: ENSP00000269300 VEGFA ENSP00000361125 4 STRING: ENSP00000361125 VEGFB ENSP00000311127 4 STRING: ENSP00000311127 VEGFC ENSP00000280193 4 STRING: ENSP00000280193 H2AFJ ENSP00000373730 4 STRING: ENSP00000373730 PTK6 ENSP00000217185 4 STRING: ENSP00000217185 TCF4 ENSP00000346440 4 STRING: ENSP00000346440 USP2 ENSP00000260187 4 STRING: ENSP00000260187 CCND1 ENSP00000227507 4 STRING: ENSP00000227507 CLTC ENSP00000269122 4 STRING: ENSP00000269122 DNM2 ENSP00000352721 4 STRING: ENSP00000352721 EPS15 ENSP00000360798 4 STRING: ENSP00000360798 MMP16 ENSP00000286614 4 STRING: ENSP00000286614 PGR ENSP00000325120 4 STRING: ENSP00000325120 PTGS2 ENSP00000356438 4 STRING: ENSP00000356438
About this table Gene Ontology (GO): 5/49 biological process terms (GO ID links to tree view) (see all 49 ): About this table
About GeneDecksing
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Drugs & Compoundsfor ERBB2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Enzo Life Sciences drugs & compounds for ERBB2
Compounds for ERBB2 available from Tocris Bioscience About this table 2 HMDB Compounds for ERBB2 About this table 2 DrugBank Compounds for ERBB2 About this table 10/125 Novoseek chemical compound relationships for ERBB2 gene (see all 125 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
trastuzumab
97.1
2051
16865596 (9), 16161043 (7), 16384610 (7), 15780499 (6) (see all 99 )
lapatinib
91.7
285
17635524 (6), 18413839 (5), 19309723 (5), 19060928 (4) (see all 99 )
estrogen
88.7
1465
7591267 (7), 1680817 (6), 7647336 (6), 12375012 (5) (see all 99 )
progesterone
87.8
1122
1345772 (5), 15743737 (5), 16085689 (4), 15979129 (4) (see all 99 )
cb 11
87.4
81
16373062 (4), 11759828 (3), 12669615 (2), 19305385 (2) (see all 54 )
tyrosine
86.1
1292
1706346 (7), 16287490 (6), 11774167 (6), 11526509 (5) (see all 99 )
pertuzumab
84.5
77
19920829 (6), 15093539 (4), 17635517 (3), 17237269 (3) (see all 32 )
gefitinib
82.5
175
17487844 (5), 17638894 (5), 11751413 (4), 12860941 (3) (see all 70 )
tamoxifen
76.8
327
11774281 (6), 15319565 (6), 17636399 (6), 11032587 (6) (see all 99 )
erlotinib
74.7
38
17283159 (3), 17094474 (3), 16373709 (2), 20130423 (1) (see all 23 )
4 PharmGKB related drug/compound annotations for ERBB2 gene About this table ERBB2
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Transcriptsfor ERBB2 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ERBB2 gene (2 alternative transcripts): NM_001005862.1 NM_004448.2 Unigene Cluster for ERBB2:
V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) Hs.446352 [show with all ESTs ] Unigene Representative Sequence: NM_001005862 18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24 ): ENST00000584601 ENST00000584014 ENST00000578199 (uc002hsl.3 ) ENST00000445658 ENST00000584450 ENST00000582648 ENST00000582788 ENST00000269571 ENST00000578373 ENST00000584908 (uc002hsn.1 ) ENST00000578709 ENST00000584099 ENST00000583038 ENST00000583391 ENST00000578502 ENST00000582818 ENST00000578630 ENST00000584684 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 6 )human mouse rat see all 4 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): ERBB2 (NM_004448 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ERBB2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ERBB2
Additional cDNA sequence: AB025286.1 AF177761.2 AK296908.1 AK300321.1 AK309029.1 AK313683.1 BC080193.1 BC110392.1 BC167147.1 HM437238.1 M11730.1 S57296.1 X03363.1
24/26 DOTS entries (see all 26 ): DT.100824047 DT.95088838
DT.120977168 DT.215753 DT.75117810 DT.97759791 DT.120977079 DT.95261294 DT.100824051 DT.100824052 DT.70100272 DT.100824048 DT.75167343 DT.95256387 DT.75191397 DT.91699968 DT.91727209 DT.92025980 DT.95090252 DT.100731961 DT.100738418 DT.120977138 DT.120977177 DT.40278576 24/323 AceView cDNA sequences (see all 323 ):
BI755753 AA025141 CK299205 BM795191 AB025286 CR591377 AW175631 CA455141 BU541491 BM830170 BM789286 AA760891 BU845369 BM692355 AU140362 BM673607 BX501707 CB305806 CA487631 CA488343 CD515356 AA025156 BU931894 AW175620 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ERBB2 (see all 6 ) About this scheme ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ SP1 : - - SP2 : - SP3 : - SP4 : - SP5 :
ExUns: 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27a · 27b SP1 : SP2 : SP3 : SP4 : SP5 :
ECgene alternative splicing isoforms for ERBB2
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Expression for ERBB2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ERBB2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AGGAAGGAACAbout this image ERBB2 expression in embryonic tissues and stem cells About this table
See ERBB2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ERBB2 SOURCE GeneReport for Unigene cluster: Hs.446352 UniProtKB/Swiss-Prot: ERBB2_HUMAN, P04626 Tissue specificity : Expressed in a variety of tumor tissues including primary breast tumors and tumors from smallbowel, esophagus, kidney and mouth SABiosciences Expression via Pathway-Focused PCR Arrays including ERBB2 (see all 13 ): Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERBB2
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Orthologsfor ERBB2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for ERBB2 gene from 6/18 species (see all 18 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves ERBB21
v-erb-b2 erythroblastic leukemia viral oncogene homolog more
73.11(n) 71.83(a)
426130 NM_001044661.1 NP_001038126.1
lizard Reptilia ERBB26
--
64(a)
1 ↔ 1
6(68362453-68402526)
African clawed frog Amphibia Xl.143902
Xenopus laevis transcribed sequence with moderate similarity more
76.71(n)
BM192617.1
zebrafish Actinopterygii erbb21
v-erb-b2 erythroblastic leukemia viral oncogene homolog more
60.69(n) 59.08(a)
386966 NM_200119.2 NP_956413.2
fruit fly Insecta Egfr3
eggshell pattern formation epidermal growthmore
39(a)
--
worm Secernentea let-233
tyrosine-protein kinase (Epidermal growthmore
34(a)
II(9197428-9206848) --
ENSEMBL Gene Tree for ERBB2 (if available)TreeFam Gene Tree for ERBB2 (if available)
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Paralogsfor ERBB2 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ERBB2 gene SYK 2 TNK1 2 JAK2 2 JAK3 2 TNK2 2 TYK2 2 ERBB4 2 JAK1 2 ERBB3 2 PTK2 2 ZAP70 2 PTK2B 2 EGFR 2 18/88 SIMAP similar genes for ERBB2 using alignment to 16 protein entries: ERBB2_HUMAN (see all proteins )
(see all similar genes ):WARS HER-2 TNFRSF17 TSEN2 ZNF564 CRCP EPHA4 APOD FAM175A HKR1 LOC100506792 NF2 UTY CHID1 HMGA2 SHANK2 TMEM14B FKBP3 About GeneDecksing
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Genomic Variantsfor ERBB2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section UniProtKB/Swiss-Prot: ERBB2_HUMAN, P04626 Polymorphism : There are four alleles due to the variations in positions 654 and 655. Allele B1 (Ile-654/Ile-655) has afrequency of 0.782; allele B2 (Ile-654/Val-655) has a frequency of 0.206; allele B3 (Val-654/Val-655) has a frequency of 0.012
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 17 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for ERBB2 (37844167 - 37886679 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for ERBB2 1 CNV 77592 Human Gene Mutation Database (HGMD) : ERBB2 5/21 SABiosciences Cancer Mutation PCR Assays for ERBB2 (see all 21 ):
5/11 SABiosciences Cancer Mutation PCR Arrays containing ERBB2 (see all 11 ):
4 SABiosciences qBiomarker Copy Number PCR Arrays containing ERBB2 :
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor ERBB2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 164870 OMIM disorders : 211980 137800 137215 UniProtKB/Swiss-Prot: ERBB2_HUMAN, P04626 Defects in ERBB2 are a cause of hereditary diffuse gastric cancer (HDGC) [MIM:137215]. A cancer predisposition syndrome with increased susceptibility to diffuse gastric cancer. Diffuse gastric cancer is a malignant disease characterized by poorly differentiated infiltrating lesions resulting in thickening of the stomach. Malignant tumors start in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body Defects in ERBB2 are involved in the development of glioma (GLM) [MIM:137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas Defects in ERBB2 are a cause of susceptibility to ovarian cancer (OC) [MIM:167000]. Ovarian cancer common malignancy originating from ovarian tissue. Although many histologic types of ovarian neoplasms have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease Defects in ERBB2 may be a cause of lung cancer (LNCR) [MIM:211980]. LNCR is a common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis Defects in ERBB2 are a cause of gastric cancer (GASC) [MIM:613659]. A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease Note=Chromosomal aberrations involving ERBB2 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with CDK12, leading to CDK12-ERBB2 fusion leading to truncated CDK12 protein not in-frame with ERBB2 20/238 (see all 238 ): About MalaCards charcot-marie-tooth disease charcot-marie-tooth disease type 1 charcot-marie-tooth disease type 1a glioblastoma progesterone-receptor negative breast cancer progesterone-receptor positive breast cancer lipid-rich carcinoma estrogen-receptor negative breast cancer estrogen-receptor positive breast cancer placental site trophoblastic tumor desmoplastic small round cell tumor malignant peripheral nerve sheath tumor microglandular adenosis uterine carcinosarcoma cleft lip/palate invasive bladder transitional cell carcinoma nonseminomatous germ cell tumor bladder transitional cell carcinoma squamous cell carcinoma recurrent respiratory papillomatosis 14 diseases from the University of Copenhagen DISEASES database for ERBB2 :Breast cancer Carcinoma Ductal carcinoma in situ Ovarian cancer Lung cancer Endometrial cancer Prostate cancer Urinary bladder cancer Neutropenia Colorectal cancer Pancreatic cancer Breast disease Diarrhea Stomach cancer 10/96 Novoseek disease relationships for ERBB2 gene (see all 96 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer
94.7
5501
11489825 (9), 12132871 (7), 12755489 (7), 9363867 (7) (see all 99 )
breast carcinoma
92.4
1090
12973835 (6), 14669272 (6), 11579337 (5), 9698539 (5) (see all 99 )
carcinoma ductal
89.4
268
12481013 (6), 16169726 (4), 15696127 (3), 18681318 (3) (see all 99 )
tumors
88.5
5807
14612517 (8), 9563885 (7), 14696118 (7), 11888924 (7) (see all 99 )
breast cancer metastatic
88.3
404
11820721 (5), 11477443 (4), 15059359 (4), 10467326 (4) (see all 99 )
carcinoma
82.7
1015
12653946 (7), 20208479 (6), 12631216 (6), 18415713 (5) (see all 99 )
cancer
82.5
1385
11774202 (7), 18498074 (7), 16740724 (6), 12942124 (6) (see all 99 )
metastasis
81.3
960
17511881 (8), 15786420 (6), 15150568 (6), 11481385 (5) (see all 99 )
invasive ductal breast carcinoma
76.8
19
17908479 (2), 18390199 (2), 11106082 (1), 11561770 (1) (see all 14 )
carcinoma lobular
75.1
24
9563885 (1), 12152162 (1), 14659337 (1), 1374218 (1) (see all 22 )
Genetic Association Database (GAD): ERBB2 Human Genome Epidemiology (HuGE) Navigator: ERBB2 (155 documents) Tumor Gene Database (TGDB) : ERBB2 Export disorders for ERBB2 gene to outside databases
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Associations of this gene to articles via
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4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ERBB2 gene, integrated from 9 sources (see all 4926 ):(articles sorted by number of sources associating them with ERBB2) Utopia : connect your pdf to the dynamic
Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. (PubMed id 12610629) 1 , 2 , 9(2003) Estrogen receptor codon 594 and HER2 codon 655 polymorphisms and breast cancer risk. (PubMed id 15126109) 1 , 4, 9(2004) ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells. (PubMed id 19372587) 1 , 2 , 9(2009) EGFR and erbB2 mutation status in Japanese lung cancer patients. (PubMed id 16003726) 1 , 4, 9(2006) The influence of HER2 genotypes as molecular markers in ovarian cancer outcome. (PubMed id 16112085) 1 , 4, 9(2005) Her2 genotype and breast cancer progression in Korean women. (PubMed id 15693849) 1 , 4, 9(2005) Vitamin D receptor, HER-2 polymorphisms and risk of prostate cancer in men with benign prostate hyperplasia. (PubMed id 15083213) 1 , 4, 9(2004) A single nucleotide polymorphism in the transmembrane domain coding region of HER-2 is associated with development and malignant phenotype of gastric cancer. (PubMed id 14520697) 1 , 4, 9(2003) No association between HER-2 gene polymorphism at codon 655 and a risk of bladder cancer. (PubMed id 11857355) 1 , 4, 9(2002) Association of HER-2 polymorphism with Japanese sporadic prostate cancer susceptibility. (PubMed id 15389808) 1 , 4, 9(2005)
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About This Section Patent Information for ERBB2 gene: ERBB2 Licensable Technologies for ERBB2 gene: GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ERBB2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
OriGene Antibodies for ERBB2 OriGene shRNA RFP for ERBB2 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for ERBB2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ERBB2 OriGene 3'-UTR Clone for ERBB2 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for ERBB2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ERBB2 OriGene Custom Protein Services for ERBB2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ERBB2 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for ERBB2 (HER2)
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERBB2
ThermoFisher Antibody for ERBB2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ERBB2
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summary
for 
and Proteopedia 
for ERBB2 (
BioSystems Pathways for ERBB2 (
PharmGKB Pathway for 
Kegg Pathways 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Microarrays
