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ERBB2 Gene

protein-coding   GIFtS: 79
GCID: GC17P037844

V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog...

(Previous name: v-erb-b2 avian erythroblastic leukemia viral oncogene homolog...)
(Previous symbol: NGL)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 21 2     CD3402
NGL1 2 3 5     HER-22
HER22 3 5     HER-2/neu2
NEU2 3 5     TKR12
Neuro/Glioblastoma Derived Oncogene Homolog1 2     C-Erb B2/Neu Protein2
Metastatic Lymph Node Gene 19 Protein2 3     herstatin2
Proto-Oncogene C-ErbB-22 3     Neuroblastoma/Glioblastoma Derived Oncogene Homolog2
Proto-Oncogene Neu2 3     Receptor Tyrosine-Protein Kinase ErbB-22
Tyrosine Kinase-Type Cell Surface Receptor HER22 3     V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2,
Neuro/Glioblastoma Derived Oncogene Homolog2
MLN 192 3     MLN193
p185erbB22 3     CD340 Antigen3
EC 2.7.10.13 8     EC 2.7.108
V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2
(Neuro/Glioblastoma Derived Oncogene Homolog)1
     

External Ids:    HGNC: 34301   Entrez Gene: 20642   Ensembl: ENSG000001417367   OMIM: 1648705   UniProtKB: P046263   

Export aliases for ERBB2 gene to outside databases

Previous GC identifers: GC17P037262 GC17P039854 GC17P037766 GC17P038231 GC17P035109 GC17P033638


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ERBB2 Gene:
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This
protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind
tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and
enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated
protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of
isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655,
shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including
breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding
different isoforms and others that have not been fully characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for ERBB2 Gene:
ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2) is a protein-coding gene. Diseases associated with ERBB2 include ductal carcinoma in situ, and breast scirrhous carcinoma. GO annotations related to this gene include protein C-terminus binding and identical protein binding. An important paralog of this gene is SYK.

UniProtKB/Swiss-Prot: ERBB2_HUMAN, P04626
Function: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently
needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins
do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and
stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway
elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation
of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the
localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization
Function: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in
the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the
function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein
synthesis and cell growth

summary for ERBB2 Gene:
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members
of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4).
EGFR signaling is initiated by ligand binding to the extracellular ligand binding domain. This initiates
receptor homo-/hetero-dimerization and autophosphorylation by the intracellular kinase domain, resulting in
receptor activation. Following activation, phosphorylation of cytoplasmic substrates occurs and a signaling
cascade is initiated that drives many cellular responses, including changes in gene expression, cytoskeletal
rearrangement, anti-apoptosis and increased cell proliferation.

Gene Wiki entry for ERBB2 (HER2/neu) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ERBB2 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ERBB2 promoter sequence
   Search Chromatin IP Primers for ERBB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ERBB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2-q12

ERBB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ERBB2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P037844:  view genomic region     (about GC identifiers)

Start:
37,844,167 bp from pter      End:
37,886,679 bp from pter
Size:
42,513 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ERBB2_HUMAN, P04626 (See protein sequence)
Recommended Name: Receptor tyrosine-protein kinase erbB-2 precursor  
Size: 1255 amino acids; 137910 Da
Subunit: Homodimer. Heterodimer with EGFR, ERBB3 and ERBB4. Part of a complex with EGFR and either PIK3C2A or
PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with PRKCABP and PLXNB1. Interacts
(when phosphorylated on Tyr-1248) with MEMO1. Interacts with MUC1; the interaction is enhanced by heregulin
(HRG). Interacts (when phosphorylated on Tyr-1139) with GRB7 (via SH2 domain). Interacts (when phosphorylated on
Tyr-1248) with ERBB2IP. Interacts with KPNB1, RANBP2, EEA1, CRM1, CLTC, PTK6, RPA94 and ACTB. Interacts with SRC
(By similarity)
Selected PDB 3D structures from and Proteopedia for ERBB2 (see all 21):
1MFG (3D)        1MFL (3D)        1MW4 (3D)        1N8Z (3D)        1OVC (3D)        1QR1 (3D)    
Secondary accessions: B2RZG3 B4DHN3 Q14256 Q6LDV1 Q9UMK4
Alternative splicing, Alternative initiation: 4 isoforms:  P04626-1   P04626-2   P04626-3   P04626-4   (Produced by alternative splicing of isoform 1)

Explore the universe of human proteins at neXtProt for ERBB2: NX_P04626

Explore proteomics data for ERBB2 at MOPED

Post-translational modifications: 

  • Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues. Autophosphorylation occurs in
    trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Signaling
    via SEMA4C promotes phosphorylation at Tyr-12481
  • Ubiquitination2 at Lys724, Lys736, Lys747, Lys753, Lys860
  • Glycosylation2 at Asn68, Asn124, Asn187, Asn259, Asn530, Asn571, Asn629
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ERBB2 (P04626) (see all 35)
     KPYDGIP  RDLAARN  AENPEYL  MARDPQR 


    See ERBB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001005862.1  NP_001276865.1  NP_001276866.1  NP_001276867.1  NP_004439.2  

    ENSEMBL proteins: 
     ENSP00000462438   ENSP00000462808   ENSP00000404047   ENSP00000463714   ENSP00000462024  
     ENSP00000463427   ENSP00000269571   ENSP00000463719   ENSP00000462270   ENSP00000464420  
     ENSP00000464252   ENSP00000463002   ENSP00000446466   ENSP00000385185   ENSP00000443562  
     ENSP00000446382  
    Reactome Protein details: P04626

    ERBB2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ERBB2 (ErbB2/Her2)
    Enzo Life Sciences proteins for ERBB2
    OriGene Purified Proteins for ERBB2
    OriGene Protein Over-expression Lysate for ERBB2
    OriGene MassSpec for ERBB2
    OriGene Custom Protein Services for ERBB2
    GenScript Custom Purified and Recombinant Proteins Services for ERBB2
    Novus Biologicals ERBB2 Proteins
    Novus Biologicals ERBB2 Lysate
    Sino Biological Recombinant Protein for ERBB2
    Sino Biological Cell Lysate for ERBB2
    ProSpec Recombinant Protein for ERBB2
    Browse Proteins at Cloud-Clone Corp.

    ERBB2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ERBB2
    R&D Systems Antibodies for ERBB2 (ErbB2/Her2)
    Cell Signaling Technology (CST) Antibodies for ERBB2  (HER2)
    OriGene Antibodies for ERBB2
    OriGene Custom Antibody Services for ERBB2
    Novus Biologicals ERBB2 Antibodies
    Abcam antibodies for ERBB2
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for ERBB2
    LSBio Antibodies in human, mouse, rat for ERBB2

    ERBB2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ERBB2
    R&D Systems ELISAs for ERBB2 (ErbB2/Her2)         (see all)
    GenScript Custom Assay Services for ERBB2
    Cell Signaling Technology (CST) Sandwich ELISA Kits for ERBB2 (HER2)
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    IUPHAR Guide to PHARMACOLOGY protein family classification: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
    ErbB (epidermal growth factor) receptor family

    Selected InterPro protein domains (see all 11):
     IPR017441 Protein_kinase_ATP_BS
     IPR006212 Furin_repeat
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom
     IPR000494 EGF_rcpt_L

    Graphical View of Domain Structure for InterPro Entry P04626

    ProtoNet protein and cluster: P04626

    5 Blocks protein domains:
    IPB000494 Epidermal growth-factor receptor (EGFR)
    IPB004019 YLP motif
    IPB006211 Furin-like cysteine rich region
    IPB006212 Furin-like repeat
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: ERBB2_HUMAN, P04626
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily
    Similarity: Contains 1 protein kinase domain


    ERBB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ERBB2_HUMAN, P04626
    Function: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently
    needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins
    do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and
    stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway
    elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation
    of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the
    localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization
    Function: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in
    the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the
    function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein
    synthesis and cell growth
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Activated by dimerization. Not activated by EGF, TGF-alpha and amphiregulin. Interaction with
    PTK6 increases its intrinsic kinase activity

         Genatlas biochemistry entry for ERBB2:
    avian erythroblastic leukemia viral (v-erb-b) oncogene homolog 2,HERC2/neu receptor tyrosine
    kinase,neuroglioblastoma derived,constitutively acting as a coreceptor for multiple stroma-derived growth factors
    i.e EGF-like ligands and neuregulins after heterodimerization with other ERBBs,involved in androgen receptor
    transactivation of inducing prostate-specific antigen (PSA) through the MAP kinase pathway,signal transducer,also
    presenting as a secreted transcript herstatin,expressed in normal fetal kidney and liver,potential inhibitor of
    ERBB2,commonly amplified in primary breast cancer and in endometrial cancer,coamplified with GRB7 in primary
    gastric cancer,and in prostate carcinoma with metastasis and poor prognosis

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001042RNA polymerase I core binding IDA--
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity TAS--
    GO:0004714transmembrane receptor protein tyrosine kinase activity IDA7514177
    GO:0004716receptor signaling protein tyrosine kinase activity IEA--
         
    ERBB2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ERBB2:
     Decreased focal adhesion (FA)   Decreased viability with pacli 

         Selected MGI mutant phenotypes (inferred from 17 alleles(MGI details for Erbb2) (see all 19):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  integument 
     limbs/digits/tail  mortality/aging  muscle  nervous system  normal 

    ERBB2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ERBB2: Erbb2tm1Vrtn Erbb2tm1Gne Erbb2tm2Mul Erbb2tm1Haus Erbb2tm2.1Cbm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ERBB2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ERBB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ERBB2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ERBB2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ERBB2:
    hsa-mir-124-3p (MIRT023179), hsa-mir-326 (MIRT043637), hsa-mir-559 (MIRT000036), hsa-mir-21-5p (MIRT004318), hsa-mir-125b-5p (MIRT002939), hsa-mir-125a-5p (MIRT005118), hsa-mir-331-3p (MIRT005805), hsa-mir-199a-5p (MIRT007265), hsa-mir-205-5p (MIRT006982), hsa-mir-548d-3p (MIRT000037), hsa-mir-199b-5p (MIRT007152)

    Block miRNA regulation of human, mouse, rat ERBB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ERBB2 (see all 11):
    hsa-miR-548d-3p hsa-miR-3664-5p hsa-miR-452* hsa-miR-3921 hsa-miR-221* hsa-miR-146a* hsa-miR-593 hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidERBB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ERBB2
    Predesigned siRNA for gene silencing in human, mouse, rat ERBB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ERBB2

    Clone
    Products:
         
    OriGene clones in human, mouse for ERBB2 (see all 16)
    OriGene ORF clones in mouse, rat for ERBB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ERBB2 (NM_004448)
    Sino Biological Human cDNA Clone for ERBB2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERBB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERBB2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ERBB2
    Browse ESI BIO Cell Lines and PureStem Progenitors for ERBB2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERBB2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ERBB2_HUMAN, P04626: Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear
    region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is
    mediated by importin beta-1/KPNB1
    ERBB2_HUMAN, P04626: Isoform 2: Cytoplasm. Nucleus
    ERBB2_HUMAN, P04626: Isoform 3: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    nucleus5
    plasma membrane5
    cytoskeleton3
    extracellular3
    cytosol2
    endoplasmic reticulum2
    lysosome1
    mitochondrion1
    peroxisome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane TAS--
    GO:0010008endosome membrane IDA16314522
    GO:0016020membrane ----

    ERBB2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ERBB2 About   (see all 55)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52
    ErbB receptor signaling network0.00
    2Development EGFR signaling pathway
    Development EGFR signaling pathway0.57
    EGF Pathway0.39
    Development ERBB family signaling0.57
    GRB7 events in ERBB2 signaling0.00
    3Glioma
    Non-small cell lung cancer0.51
    Signaling Pathways in Glioblastoma0.36
    Prostate cancer0.39
    Bladder cancer0.31
    4Focal adhesion
    Focal adhesion0.65
    Focal Adhesion0.65
    5Signaling by FGFR
    Signaling by FGFR0.91
    Signaling by PDGF0.87
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.83
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR in Cancer0.82
    Downstream signal transduction0.90
    NGF signalling via TRKA from the plasma membrane0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for ERBB2
        Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ERBB2 (see all 38)
        Paxillin Interactions
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    JNK Pathway
    Tec Kinases Signaling

    1 Cell Signaling Technology (CST) Pathway for ERBB2
        Tyrosine Kinases / Adaptors

    4 Tocris Bioscience Pathways for ERBB2
        Akt Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for ERBB2 (see all 8)
        Development ERBB-family signaling
    Development Ligand-independent activation of ESR1 and ESR2
    Apoptosis and survival Role of CDK5 in neuronal death and survival
    Development EGFR signaling via PIP3
    Development EGFR signaling pathway

    Selected BioSystems Pathways for ERBB2 (see all 14)
        Focal Adhesion
    DNA damage response (only ATM dependent)
    ErbB signaling pathway
    Signaling Pathways in Glioblastoma
    Alpha6-Beta4 Integrin Signaling Pathway

    1 Sino Biological Pathway for ERBB2
        EGFR Signaling Pathway

    Selected Reactome Pathways for ERBB2 (see all 10)
        Downregulation of ERBB2:ERBB3 signaling
    GRB7 events in ERBB2 signaling
    GRB2 events in ERBB2 signaling
    PI3K events in ERBB2 signaling
    SHC1 events in ERBB2 signaling

    1 PharmGKB Pathway for ERBB2
        EGFR Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for ERBB2) (see all 13):
        ErbB signaling pathway
    Calcium signaling pathway
    HIF-1 signaling pathway
    Focal adhesion
    Adherens junction


    ERBB2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ERBB2 (see all 13): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Neurogenesis in human mouse rat
              Lung Cancer in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Angiogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ERBB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ERBB2 (P046261, 2, 3 ENSP000002695714) via UniProtKB, MINT, STRING, and/or I2D (see all 358)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R3Q925691, 2, 3, ENSP000002627414EBI-641062,EBI-79893 MINT-74664 MINT-74642 MINT-74650 MINT-74662 MINT-74660 MINT-74649 MINT-74663 MINT-74641 MINT-74661 I2D: score=2 STRING: ENSP00000262741
    PIK3R2O004591, 2, 3, ENSP000002222544EBI-641062,EBI-346930 MINT-74622 MINT-74623 MINT-74620 MINT-74631 MINT-74621 MINT-61505 MINT-74632 I2D: score=5 STRING: ENSP00000222254
    SYKP434051, 2, 3, ENSP000003648984EBI-641062,EBI-78302 MINT-74765 MINT-74767 MINT-74769 MINT-74758 MINT-74768 MINT-74764 MINT-74766 I2D: score=2 STRING: ENSP00000364898
    SHC1P293531, 2, 3, ENSP000004013034EBI-641062,EBI-78835 MINT-61510 MINT-61506 MINT-74737 MINT-61504 MINT-74734 MINT-74736 MINT-61508 MINT-74733 MINT-74735 MINT-61511 I2D: score=8 STRING: ENSP00000401303
    RASA1P209361, 2, 3, ENSP000002743764EBI-641062,EBI-1026476 MINT-74698 MINT-74702 MINT-74697 MINT-74701 MINT-74699 MINT-74712 MINT-74700 I2D: score=2 STRING: ENSP00000274376
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 39):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation ISS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006468protein phosphorylation TAS10851066
    GO:0007165signal transduction IDA10572067
    GO:0007166cell surface receptor signaling pathway IDA9685399

    ERBB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for ERBB2
      Browse compounds at ApexBio 

    Compounds for ERBB2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Iressa Orally active, selective EGFR inhibitor [184475-35-2]
    AG 490 EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor [133550-30-8]
    JNJ 28871063 hydrochloridePotent ErbB receptor family inhibitor[944341-54-2]
    AG 1478 hydrochlorideHighly potent EGFR-kinase inhibitor[153436-53-4]
    GenisteinEGFR kinase inhibitor. Also estrogen and PPARgamma ligand[446-72-0]

    2 HMDB Compounds for ERBB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    5 DrugBank Compounds for ERBB2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    LapatinibFMM (see all 5)388082-78-8targetantagonist15163842 14751502 16894399 20110044 12214266 18803986 14967461 14737100 11752352 20658522 15374980 14633707
    TrastuzumabAnti HER2 (see all 2)180288-69-1targetantibody17660958 11752352 18690878 11098307
    ado-trastuzumab emtansineRG-3502 (see all 4)1018448-65-targetantibody23196784 11752352 19010901
    Pertuzumab2C4 Antibody (see all 6)380610-27-5targetantibody15093539
    Afatinib-- 850140-72-6targetinhibitor--

    Selected Novoseek inferred chemical compound relationships for ERBB2 gene (see all 125)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trastuzumab 97.1 2051 16865596 (9), 16161043 (7), 16384610 (7), 15780499 (6) (see all 99)
    lapatinib 91.7 285 17635524 (6), 18413839 (5), 19309723 (5), 19060928 (4) (see all 99)
    estrogen 88.7 1465 7591267 (7), 1680817 (6), 7647336 (6), 12375012 (5) (see all 99)
    progesterone 87.8 1122 1345772 (5), 15743737 (5), 16085689 (4), 15979129 (4) (see all 99)
    cb 11 87.4 81 16373062 (4), 11759828 (3), 12669615 (2), 19305385 (2) (see all 54)
    tyrosine 86.1 1292 1706346 (7), 16287490 (6), 11774167 (6), 11526509 (5) (see all 99)
    pertuzumab 84.5 77 19920829 (6), 15093539 (4), 17635517 (3), 17237269 (3) (see all 32)
    gefitinib 82.5 175 17487844 (5), 17638894 (5), 11751413 (4), 12860941 (3) (see all 70)
    tamoxifen 76.8 327 11774281 (6), 15319565 (6), 17636399 (6), 11032587 (6) (see all 99)
    erlotinib 74.7 38 17283159 (3), 17094474 (3), 16373709 (2), 20130423 (1) (see all 23)

    5 PharmGKB related drug/compound annotations for ERBB2 gene    About this table
    Drug/compound PharmGKB Annotation
    Pertuzumab
    everolimus
    lapatinib
    trastuzumab  CA  
    trastuzumab emtansine



    ERBB2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for ERBB2 gene (5 alternative transcripts): 
    NM_001005862.2  NM_001289936.1  NM_001289937.1  NM_001289938.1  NM_004448.3  

    Unigene Cluster for ERBB2:

    V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
    Hs.446352  [show with all ESTs]
    Unigene Representative Sequence: NM_001005862
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000584601 ENST00000584014 ENST00000578199(uc002hsl.3) ENST00000445658
    ENST00000584450 ENST00000582648 ENST00000582788 ENST00000578373 ENST00000269571
    ENST00000584908(uc002hsn.1) ENST00000578709 ENST00000584099 ENST00000583038
    ENST00000583391 ENST00000578502 ENST00000582818 ENST00000578630 ENST00000584684

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ERBB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ERBB2 (see all 11):
    hsa-miR-548d-3p hsa-miR-3664-5p hsa-miR-452* hsa-miR-3921 hsa-miR-221* hsa-miR-146a* hsa-miR-593 hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidERBB2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ERBB2
    Predesigned siRNA for gene silencing in human, mouse, rat ERBB2
    Clone
    Products:
         
    OriGene clones in human, mouse for ERBB2 (see all 16)
    OriGene ORF clones in mouse, rat for ERBB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ERBB2 (NM_004448)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERBB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERBB2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ERBB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ERBB2
      QuantiTect SYBR Green Assays in human, mouse, rat ERBB2
      QuantiFast Probe-based Assays in human, mouse, rat ERBB2

    Additional mRNA sequence: 

    AB025286.1 AF177761.2 AK296908.1 AK300321.1 AK309029.1 AK313683.1 BC080193.1 BC110392.1 
    BC167147.1 HM437238.1 M11730.1 S57296.1 X03363.1 

    Selected DOTS entries (see all 26):

    DT.100824047  DT.95088838  DT.120977168  DT.215753  DT.75117810  DT.97759791  DT.120977079  DT.95261294 
    DT.100824051  DT.100824052  DT.70100272  DT.100824048  DT.75167343  DT.95256387  DT.75191397  DT.91699968 
    DT.91727209  DT.92025980  DT.95090252  DT.100731961  DT.100738418  DT.120977138  DT.120977177  DT.40278576 

    Selected AceView cDNA sequences (see all 323):

    BM672297 BM758528 NM_004448 AW175620 BI755753 AA765693 BM789286 BM673607 
    BQ717097 AA760891 BM830170 CA445529 CA455141 M11730 BU931894 CA488792 
    AK131568 AA293095 BM795191 CD515356 BF589067 CA455074 AB025286 AA995651 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ERBB2 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:                    -                                                                                   -                                                   
    SP2:                                                                                                        -                                                   
    SP3:                    -                                                                                                                                       
    SP4:                                                                                                                          -                                 
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27a · 27b
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for ERBB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ERBB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAAGGAAC
    ERBB2 Expression
    About this image


    ERBB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 6 entries
             Immature Schwann Cells Peripheral Nerve Domain
             Schwann-like cells
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Endocardial Cushion Cells Atrioventricular Endocardial Cushion
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Schwann Cells (Nervous System)    fully expand to see all 2 entries
             Schwann-like cells
    ERBB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ERBB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.446352

    UniProtKB/Swiss-Prot: ERBB2_HUMAN, P04626
    Tissue specificity: Expressed in a variety of tumor tissues including primary breast tumors and tumors from small
    bowel, esophagus, kidney and mouth

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ERBB2 (see all 13): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Neurogenesis in human mouse rat
              Lung Cancer in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Angiogenesis in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ERBB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ERBB2
    QuantiTect SYBR Green Assays in human, mouse, rat ERBB2
    QuantiFast Probe-based Assays in human, mouse, rat ERBB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERBB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ERBB2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Erbb21 , 5 v-erb-b2 erythroblastic leukemia viral oncogene homolog more1, 5 85.6(n)1
    87.73(a)1
      11 (61.75 cM)5
    138661  NM_001003817.11  NP_001003817.11 
     984124705 
    chicken
    (Gallus gallus)
    Aves ERBB21 v-erb-b2 erythroblastic leukemia viral oncogene homolog more 72.97(n)
    71.76(a)
      426130  NM_001044661.1  NP_001038126.1 
    lizard
    (Anolis carolinensis)
    Reptilia ERBB26
    v-erb-b2 avian erythroblastic leukemia viral oncog...
    65(a)
    1 ↔ 1
    6(68362453-68402550)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.143902 Xenopus laevis transcribed sequence with moderate similarity more 76.71(n)    BM192617.1 
    zebrafish
    (Danio rerio)
    Actinopterygii erbb21 v-erb-b2 erythroblastic leukemia viral oncogene homolog more 60.77(n)
    59.31(a)
      386966  NM_200119.2  NP_956413.2 


    ENSEMBL Gene Tree for ERBB2 (if available)
    TreeFam Gene Tree for ERBB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for ERBB2 gene
    SYK2  TNK12  JAK32  JAK22  TNK22  TYK22  ERBB42  JAK12  
    ERBB32  PTK22  ZAP702  EGFR2  PTK2B2  
    Selected SIMAP similar genes for ERBB2 using alignment to 16 protein entries:     ERBB2_HUMAN (see all proteins) (see all similar genes):
    WARS    HER-2    TNFRSF17    TSEN2    ZNF564    ZNF737
    CRCP    ZNF100    EPHA4    APOD    FAM175A    HKR1
    NF2    UTY    ZNF738    CHID1    HMGA2    SHANK2

    ERBB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    ERBB2_HUMAN, P04626: There are four alleles due to the variations in positions 654 and 655. Allele B1 (Ile-654/Ile-655)
    has a frequency of 0.782; allele B2 (Ile-654/Val-655) has a frequency of 0.206; allele B3 (Val-654/Val-655) has a
    frequency of 0.012


    Selected SNPs for ERBB2 (see all 1038)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289333691,2,,4
    CA gastric adenocarcinoma sample4 other138668203(+) TGGCTA/GGTGTG 4 S G mis1 ese30--------
    rs289333701,2,,4
    CAn ovarian cancer sample4 other138668584(+) TCCCAA/GCCATG 4 N S mis1 ese30--------
    rs289333681,2,,4
    CA glioblastoma sample4 other138669180(+) TGTGGA/GAGCTG 4 K E mis10--------
    VAR_0554324
    A lung adenocarcinoma sample4--see VAR_0554322 L P mis40--------
    rs18012011,2,,4
    C,Fnon-pathogenic138666791(+) CGTCCA/GTCATC 4 I V mis19Minor allele frequency- G:0.01MN NA EU 6283
    rs11362011,2,,4
    C,F,Hnon-pathogenic138666794(+) CCATCA/G/TTCTCT 4 I V mis146EA NS NA MN CSA EU 11776
    rs1406704461,2
    Cuntested138659357(+) CGCACC/G/TAAGCT 4 Q * stg11NA 4546
    rs1843397341,2
    --33641664(+) AAAAAA/TATATA 1 -- int10--------
    rs720599391,2
    C--33642047(+) ATATA-/AT/CA 
            
    TATAT
    1 -- int10--------
    rs713833771,2
    C--37847827(+) ATATAC/TACACA 1 -- int12Minor allele frequency- T:0.00NA 4

    HapMap Linkage Disequilibrium report for ERBB2 (37844167 - 37886679 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ERBB2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2048CNV Insertion18451855
    nsv908219CNV Loss21882294
    nsv908207CNV Loss21882294
    esv275276CNV Loss21479260
    nsv528093CNV Loss19592680
    dgv3162n71CNV Loss21882294
    dgv40n68CNV Loss17160897
    nsv908214CNV Loss21882294
    dgv3165n71CNV Gain21882294
    esv274928CNV Gain+Loss21479260

    Human Gene Mutation Database (HGMD): ERBB2
    Selected Site Specific Mutation Identification with PCR Assays for ERBB2 (see all 21):
    Cosmic IdAA Change
    684p.E914K
    13170p.D769H
    48358p.S310F
    686p.N857S
    683p.L755P
    Selected Site Specific Cancer Mutation PCR Panels containing ERBB2 (see all 11):
    ErbB2/HER2/neu Pathway
    Ovarian Cancer
    Cancer Comprehensive Panel 384HT
    Lung Cancer
    Oncogene Panel 384HT
    4 Copy Number PCR Panels containing ERBB2:
    Oncogenes & Tumor Suppressor Genes 384HC
    Breast Cancer
    WNT Signaling
    Kinases & Phosphatases
    SeqTarget long-range PCR primers for resequencing ERBB2
    DNA2.0 Custom Variant and Variant Library Synthesis for ERBB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164870   
    OMIM disorders: 211980  137800  613659  
    UniProtKB/Swiss-Prot: ERBB2_HUMAN, P04626
  • Hereditary diffuse gastric cancer (HDGC) [MIM:137215]: A cancer predisposition syndrome with increased
    susceptibility to diffuse gastric cancer. Diffuse gastric cancer is a malignant disease characterized by poorly
    differentiated infiltrating lesions resulting in thickening of the stomach. Malignant tumors start in the
    stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby
    lymph nodes and organs. It also can metastasize to other parts of the body. Note=The gene represented in this
    entry is involved in disease pathogenesis
  • Glioma (GLM) [MIM:137800]: Gliomas are benign or malignant central nervous system neoplasms derived from
    glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes,
    oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. Note=The gene
    represented in this entry is involved in disease pathogenesis
  • Ovarian cancer (OC) [MIM:167000]: The term ovarian cancer defines malignancies originating from ovarian
    tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the
    most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of
    late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry
  • Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form
    of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes:
    squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced
    stage and has a poor prognosis. Note=The gene represented in this entry is involved in disease pathogenesis
  • Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the
    esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It
    also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to
    adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types
    are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated
    infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually
    exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in
    sporadic disease. Note=The gene represented in this entry is involved in disease pathogenesis
  • Note=Chromosomal aberrations involving ERBB2 may be a cause gastric cancer. Deletions within 17q12 region
    producing fusion transcripts with CDK12, leading to CDK12-ERBB2 fusion leading to truncated CDK12 protein not
    in-frame with ERBB2

  • Selected diseases for ERBB2 (see all 215):    
    About MalaCards
    ductal carcinoma in situ    breast scirrhous carcinoma    lipid-rich carcinoma    glioblastoma, somatic
    uterine carcinosarcoma    transitional cell carcinoma    sinonasal undifferentiated carcinoma    invasive bladder transitional cell carcinoma
    hidradenocarcinoma    adenocarcinoma of lung, somatic    sclerosing adenosis of breast    glassy cell carcinoma of the cervix
    apocrine adenosis of breast    congenital pulmonary airway malformation    fallopian tube cancer    papillary serous adenocarcinoma
    gastroesophageal junction adenocarcinoma    bladder transitional cell carcinoma    progesterone-receptor negative breast cancer    ovarian cancer, somatic

    14 diseases from the University of Copenhagen DISEASES database for ERBB2:
    Breast cancer     Carcinoma     Ductal carcinoma in situ     Ovarian cancer
    Lung cancer     Endometrial cancer     Prostate cancer     Neutropenia
    Urinary bladder cancer     Colorectal cancer     Pancreatic cancer     Breast disease
    Diarrhea     Stomach cancer

    ERBB2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for ERBB2 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 94.7 5501 11489825 (9), 12132871 (7), 12755489 (7), 9363867 (7) (see all 99)
    breast carcinoma 92.4 1090 12973835 (6), 14669272 (6), 11579337 (5), 9698539 (5) (see all 99)
    carcinoma ductal 89.4 268 12481013 (6), 16169726 (4), 15696127 (3), 18681318 (3) (see all 99)
    tumors 88.5 5807 14612517 (8), 9563885 (7), 14696118 (7), 11888924 (7) (see all 99)
    breast cancer metastatic 88.3 404 11820721 (5), 11477443 (4), 15059359 (4), 10467326 (4) (see all 99)
    carcinoma 82.7 1015 12653946 (7), 20208479 (6), 12631216 (6), 18415713 (5) (see all 99)
    cancer 82.5 1385 11774202 (7), 18498074 (7), 16740724 (6), 12942124 (6) (see all 99)
    metastasis 81.3 960 17511881 (8), 15786420 (6), 15150568 (6), 11481385 (5) (see all 99)
    invasive ductal breast carcinoma 76.8 19 17908479 (2), 18390199 (2), 11106082 (1), 11561770 (1) (see all 14)
    carcinoma lobular 75.1 24 9563885 (1), 12152162 (1), 14659337 (1), 1374218 (1) (see all 22)

    Genetic Association Database (GAD): ERBB2
    Human Genome Epidemiology (HuGE) Navigator: ERBB2 (155 documents)
    Tumor Gene Database (TGDB): ERBB2

    Export disorders for ERBB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ERBB2 gene, integrated from 10 sources (see all 5159) (see top 10):
    (articles sorted by number of sources associating them with ERBB2)
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    1. Association between HER2, TOP2A, and response to anthracycline-based preoperative chemotherapy in high-risk primary breast cancer. (PubMed id 20130985)1, 4, 9 Konecny G.E....Slamon D.J. (Breast Cancer Res. Treat. 2010)
    2. The genetic polymorphisms of HER-2 and the risk of lung cancer in a Korean population. (PubMed id 19055823)1, 4, 9 Jo U.H....Kim Y.H. (BMC Cancer 2008)
    3. Epidermal growth factor receptor and human epidermal growth factor receptor 2 gene polymorphisms in endometrial cancer in a Japanese population. (PubMed id 17644807)1, 4, 9 Kitao K....Maruo T. (Reprod Sci 2007)
    4. EGFR, ERBB2, and KRAS mutations in Korean non-small cell lung cancer patients. (PubMed id 17321325)1, 4, 9 Bae N.C....Park J.Y. (Cancer Genet. Cytogenet. 2007)
    5. The influence of HER2 genotypes as molecular markers on breast cancer outcome. (PubMed id 18721072)1, 4, 9 Mutluhan H....Seyrek E. (DNA Cell Biol. 2008)
    6. Polymorphisms of HER2 Ile655Val and cyclin D1 (CCND1) G870A are not associated with breast cancer risk but polymorphic allele of HER2 is associated with nodal metastases. (PubMed id 18237245)1, 4, 9 Naidu R....Taib N.A. (Neoplasma 2008)
    7. The influence of serum HER-2 levels and HER-2 codon 655 polymorphism on breast cancer outcome. (PubMed id 18237248)1, 4, 9 Papadopoulou E....Kortsaris A. (Neoplasma 2008)
    8. Impact of HER2 and EGFR gene status on gefitinib-treated patients with nonsmall-cell lung cancer. (PubMed id 17487844)1, 4, 9 Soh J....Date H. (Int. J. Cancer 2007)
    9. Topoisomerase II alpha and responsiveness of breast cancer to adjuvant chemotherapy. (PubMed id 19401546)1, 4, 9 O'Malley F.P....Pritchard K.I. (J. Natl. Cancer Inst. 2009)
    10. Role of the HER2 [Ile655Val] genetic polymorphism in tumorogenesis and in the risk of trastuzumab-related cardiotoxicity. (PubMed id 17693647)1, 4, 9 Beauclair S....Milano G. (Ann. Oncol. 2007)
    11. Insights into ErbB signaling from the structure of the ErbB2- pertuzumab complex. (PubMed id 15093539)2, 7, 9 Franklin M.C....Sliwkowski M.X. (Cancer Cell 2004)
    12. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. (PubMed id 12610629)1, 2, 9 Cho H.-S.... Leahy D.J. (Nature 2003)
    13. Correlations of EGFR mutations and increases in EGFR and HER2 copy number to gefitinib response in a retrospective analysis of lung cancer patients. (PubMed id 17626639)1, 4, 9 Pugh T.J....Marra M.A. (BMC Cancer 2007)
    14. Estrogen receptor codon 594 and HER2 codon 655 polymorphisms and breast cancer risk. (PubMed id 15126109)1, 4, 9 Akisik E. and Dalay N. (Exp. Mol. Pathol. 2004)
    15. [Association between HRE-2 gene polymorphism at codon 655 and genetic susceptibility of colorectal cancer]. (PubMed id 19504444)1, 4, 9 Liang X....Chen K. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2009)
    16. Outcome of patients with early-stage breast cancer treated with doxorubicin-based adjuvant chemotherapy as a function of HER2 and TOP2A status. (PubMed id 19620488)1, 4, 9 Tubbs R....Hayes D.F. (J. Clin. Oncol. 2009)
    17. ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells. (PubMed id 19372587)1, 2, 9 Hawthorne V.S.... Yu D. (Mol. Cancer Res. 2009)
    18. EGFR and HER2 gene copy number and response to first-line chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). (PubMed id 17473658)1, 4, 9 Cappuzzo F....Varella-Garcia M. (J Thorac Oncol 2007)
    19. Investigation of HER-2 codon 655 single nucleotide polymorphism frequency and c-ErbB-2 protein expression alterations in gastric cancer patients. (PubMed id 16718853)1, 4, 9 Satiroglu-Tufan N.L....Calli-Demirkan N. (World J. Gastroenterol. 2006)
    20. EGFR and erbB2 mutation status in Japanese lung cancer patients. (PubMed id 16003726)1, 4, 9 Sasaki H....Fujii Y. (Int. J. Cancer 2006)
    21. The influence of HER2 genotypes as molecular markers in ovarian cancer outcome. (PubMed id 16112085)1, 4, 9 Pinto D....Medeiros R. (Biochem. Biophys. Res. Commun. 2005)
    22. Her2 genotype and breast cancer progression in Korean women. (PubMed id 15693849)1, 4, 9 An H.J....Lee K.S. (Pathol. Int. 2005)
    23. Vitamin D receptor, HER-2 polymorphisms and risk of prostate cancer in men with benign prostate hyperplasia. (PubMed id 15083213)1, 4, 9 Tayeb M.T....McLeod H.L. (Saudi Med J 2004)
    24. A single nucleotide polymorphism in the transmembrane domain coding region of HER-2 is associated with development and malignant phenotype of gastric cancer. (PubMed id 14520697)1, 4, 9 Kuraoka K....Yasui W. (Int. J. Cancer 2003)
    25. No association between HER-2 gene polymorphism at codon 655 and a risk of bladder cancer. (PubMed id 11857355)1, 4, 9 Wang L....Kato T. (Int. J. Cancer 2002)
    26. Expression and mutation analysis of her2 in head and neck squamous cell carcinoma. (PubMed id 20014947)1, 4, 9 Ali M.A....Nagatsuka H. (Cancer Invest. 2010)
    27. HER2 codon 655 polymorphism is associated with advanced uterine cervical carcinoma. (PubMed id 20026098)1, 4, 9 Kruszyna A.8....JagodziA8ski P.P. (Clin. Biochem. 2010)
    28. The Val allele of HER-2 codon 655 predicts the progression of oral squamous cell carcinoma. (PubMed id 18849186)1, 4, 9 Wu C.H....Kao S.Y. (Oral Oncol. 2009)
    29. Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas. (PubMed id 16397024)1, 4, 9 Lee J.W....Lee S.H. (Clin. Cancer Res. 2006)
    30. Comprehensive analysis of the ATM, CHEK2 and ERBB2 genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study. (PubMed id 17132159)1, 4, 9 EinarsdA^ttir K....WedrAcn S. (Breast Cancer Res. 2006)
    31. Association of HER-2 polymorphism with Japanese sporadic prostate cancer susceptibility. (PubMed id 15389808)1, 4, 9 Yokomizo A....Naito S. (Prostate 2005)
    32. Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2. (PubMed id 15380516)1, 2, 9 Wang S.C....Hung M.C. (Cancer Cell 2004)
    33. Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016. (PubMed id 14737100)1, 7, 9 Xia W....Spector N.L. (Oncogene 2004)
    34. The HER2 I655V polymorphism and breast cancer risk in Ashkenazim. (PubMed id 14569185)1, 4, 9 Rutter J.L....Struewing J. (Epidemiology 2003)
    35. Ethnic variation in the HER-2 codon 655 genetic polymorphism previously associated with breast cancer. (PubMed id 12166652)1, 4, 9 Ameyaw M.M....McLead H.L. (J. Hum. Genet. 2002)
    36. Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. (PubMed id 10805725)1, 2, 9 Arcaro A....Domin J. (Mol. Cell. Biol. 2000)
    37. Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. (PubMed id 21555369)1, 2 Li L.Y.... Hung M.C. (Cancer Res. 2011)
    38. Lapatinib, a dual HER1/HER2 tyrosine kinase inhibitor, augments basal cleavage of HER2 extracellular domain (ECD) to inhibit HER2-driven cancer cell growth. (PubMed id 20658522)1, 7 Vazquez-Martin A....Menendez J.A. (J. Cell. Physiol. 2011)
    39. Dissociation of epidermal growth factor receptor and ErbB2 heterodimers in the presence of somatostatin receptor 5 modulate signaling pathways. (PubMed id 21190959)1, 2 Kharmate G.... Kumar U. (Endocrinology 2011)
    40. Structural analysis of the mechanism of inhibition and allosteric activation of the kinase domain of HER2 protein. (PubMed id 21454582)1, 2 Aertgeerts K.... Sogabe S. (J. Biol. Chem. 2011)
    41. Lack of association between HER2 codon 655 polymorphism and breast cancer susceptibility: meta-analysis of 22 studies involving 19,341 subjects. (PubMed id 20524057)1, 4 Ma Y....Qin H. (Breast Cancer Res. Treat. 2011)
    42. Clinicopathologic features of non-small-cell lung cancer with EML4-ALK fusion gene. (PubMed id 20183914)1, 4 Takahashi T....Date H. (Ann. Surg. Oncol. 2010)
    43. P53 codon 72 and HER2 codon 655 polymorphisms in Turkish breast cancer patients. (PubMed id 20380571)1, 4 Kara N....Bagci H. (DNA Cell Biol. 2010)
    44. Alterations in p53, BRCA1, ATM, PIK3CA, and HER2 genes and their effect in modifying clinicopathological characteristics and overall survival of Bulgarian patients with breast cancer. (PubMed id 20177704)1, 4 Bozhanov S.S....Georgieva E.I. (J. Cancer Res. Clin. Oncol. 2010)
    45. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    46. HER2 Ile655Val polymorphism contributes to breast cancer risk: evidence from 27 case-control studies. (PubMed id 20401632)1, 4 Lu S....Hao X. (Breast Cancer Res. Treat. 2010)
    47. ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. (PubMed id 20937854)1, 2 Zaoui K.... Badache A. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    48. Polymorphisms in the BRCA1 and ABCB1 genes modulate menopausal hormone therapy associated breast cancer risk in postmenopausal women. (PubMed id 19672706)1, 4 (Breast Cancer Res. Treat. 2010)
    49. Epidermal growth factor receptor and vascular endothelial growth factor receptor 2 are specific biomarkers in triple-negative breast cancer. Results from a controlled randomized trial with long-term follow-up. (PubMed id 20135347)1, 4 RydAcn L....FernAP M. (Breast Cancer Res. Treat. 2010)
    50. Somatic mutation of epidermal growth factor receptor in a small subset of cutaneous squamous cell carcinoma. (PubMed id 19812598)1, 4 Ridd K. and Bastian B.C. (J. Invest. Dermatol. 2010)
    51. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    52. Predictors of gefitinib outcomes in advanced non-small cell lung cancer (NSCLC): study of a comprehensive panel of molecular markers. (PubMed id 19473722)1, 4 Tiseo M....Ardizzoni A. (Lung Cancer 2010)
    53. HER2 polymorphisms and breast cancer in Tunisian women. (PubMed id 19929405)1, 4 Kallel I....RebaA^ A. (Genet Test Mol Biomarkers 2010)
    54. Somatic mutations in epidermal growth factor receptor signaling pathway genes in non-small cell lung cancers. (PubMed id 20881644)1, 4 Lee S.Y....Park J.Y. (J Thorac Oncol 2010)
    55. A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk. (PubMed id 20446891)1, 4 Andersson U....Melin B. (Acta Oncol 2010)
    56. Multiple genetic copy number alterations in oral squamous cell carcinoma: study of MYC, TP53, CCDN1, EGFR and ERBB2 status in primary and metastatic tumours. (PubMed id 20662834)1, 4 MartA-n-Ezquerra G....Pujol R.M. (Br. J. Dermatol. 2010)
    57. Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PubMed id 19339270)1, 4 Canova C....Brennan P. (Cancer Res. 2009)
    58. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (amp 2009)
    59. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    60. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    61. Heritable variation of ERBB2 and breast cancer risk. (PubMed id 19336545)1, 4 Breyer J.P....Smith J.R. (amp 2009)
    62. Association of EGFR and HER2 polymorphisms with risk and clinical features of thyroid cancer. (PubMed id 19860576)1, 4 RebaA^ M....RebaA^ A. (Genet Test Mol Biomarkers 2009)
    63. The effects of obesity and HER-2 polymorphisms as risk factors for endometrial cancer in Korean women. (PubMed id 19438491)1, 4 Tong S.Y....Kwon S.Y. (BJOG 2009)
    64. HER2 codon 655 polymorphism and breast cancer risk: a meta-analysis. (PubMed id 18438707)1, 4 Tao W....Jiang H. (Breast Cancer Res. Treat. 2009)
    65. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    66. Genetic polymorphisms in the EGFR (R521K) and estrogen receptor (T594T) genes, EGFR and ErbB-2 protein expression, and breast cancer risk in Tunisia. (PubMed id 19636371)1, 4 Kallel I....RebaA^ A. (amp 2009)
    67. Genetic mutations associated with cigarette smoking in pancreatic cancer. (PubMed id 19351817)1, 4 Blackford A....Hruban R.H. (Cancer Res. 2009)
    68. Tagging single-nucleotide polymorphisms in candidate oncogenes and susceptibility to ovarian cancer. (PubMed id 19240718)1, 4 Quaye L....Gayther S.A. (Br. J. Cancer 2009)
    69. Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies. (PubMed id 19956635)1, 4 Holmes M.V....Casas J.P. (PLoS ONE 2009)
    70. The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer. (PubMed id 19094228)1, 4 Tapper W....Eccles D. (Breast Cancer Res. 2008)
    71. Human epithelial growth factor receptor 2[Ile655Val] polymorphism and risk of breast fibroadenoma. (PubMed id 18090908)1, 4 Zubor P....Danko J. (Eur. J. Cancer Prev. 2008)
    72. Evaluation of predictive and prognostic significance of serum TGF-beta1 levels in breast cancer according to HER-2 codon 655 polymorphism. (PubMed id 18348656)1, 4 Papadopoulou E....Kortsaris A. (Neoplasma 2008)
    73. Brk is coamplified with ErbB2 to promote proliferation in breast cancer. (PubMed id 18719096)1, 2 Xiang B.... Muthuswamy S.K. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    74. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    75. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (Genet. Med. 2008)
    76. The effects of common genetic variants in oncogenes on ovarian cancer survival. (PubMed id 18794094)1, 4 Quaye L....Song H. (Clin. Cancer Res. 2008)
    77. ERBB2 genetic polymorphism and breast cancer risk in Chinese women: a population-based case-control study. (PubMed id 17687647)1, 4 Qu S....Zheng W. (Breast Cancer Res. Treat. 2008)
    78. A case-control study of the HER2 Ile655Val polymorphism and risk of breast cancer in Taiwan. (PubMed id 18062925)1, 4 Lee S.C....Tsai L.Y. (Clin. Biochem. 2008)
    79. Screening and validation of dinucleotide repeats in intron 1 of the human EGFR gene and its paralog in the HER2 gene. (PubMed id 18946768)1, 4 Kharrat N....RebaA^ A. (J. Recept. Signal Transduct. Res. 2008)
    80. HER-2/neu Ile655Val polymorphism and the risk of breast cancer. (PubMed id 18837888)1, 4 Siddig A....Adem A. (Ann. N. Y. Acad. Sci. 2008)
    81. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (amp 2008)
    82. Allelic imbalance of HER-2 codon 655 polymorphism among different religious/ethnic populations of northern Greece and its association with the development and the malignant phenotype of breast cancer. (PubMed id 17918664)1, 4 Papadopoulou E....Kortsaris A. (Neoplasma 2007)
    83. 655Val and 1170Pro ERBB2 SNPs in familial breast cancer risk and BRCA1 alterations. (PubMed id 17452776)1, 4 Tommasi S....Paradiso A. (Cell. Oncol. 2007)
    84. Effect of ATM, CHEK2 and ERBB2 TAGSNPs and haplotypes on endometrial cancer risk. (PubMed id 17164260)1, 4 EinarsdA^ttir K....WedrAcn S. (Hum. Mol. Genet. 2007)
    85. Mammographic density and candidate gene variants: a twins and sisters study. (PubMed id 17627014)1, 4 Stone J....Hopper J.L. (amp 2007)
    86. Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4. (PubMed id 17487277)1, 4 Marks J.L....Pao W. (PLoS ONE 2007)
    87. HapMap-based study of the 17q21 ERBB2 amplicon in susceptibility to breast cancer. (PubMed id 17117180)1, 4 Benusiglio P.R....Ponder B.A. (Br. J. Cancer 2006)
    88. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    89. HER-2 codon 655 polymorphism in cervical carcinogenesis. (PubMed id 16445653)1, 4 Ueda M....Ueki M. (Int. J. Gynecol. Cancer 2006)
    90. Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation. (PubMed id 16794579)1, 2 Anido J.... Arribas J. (EMBO J. 2006)
    91. A haplotype analysis of HER-2 gene polymorphisms: association with breast cancer risk, HER-2 protein expression in the tumor, and disease recurrence in Korea. (PubMed id 16000574)1, 4 Han W....Noh D.Y. (Clin. Cancer Res. 2005)
    92. The erbB2/HER2/neu receptor polymorphism Ile655Val and breast cancer risk. (PubMed id 15970791)1, 4 Cox D.G....Hunter D.J. (Pharmacogenet. Genomics 2005)
    93. The rare ERBB2 variant Ile654Val is associated with an increased familial breast cancer risk. (PubMed id 15550452)1, 4 Frank B....Burwinkel B. (Carcinogenesis 2005)
    94. The association of p53 mutations and p53 codon 72, Her 2 codon 655 and MTHFR C677T polymorphisms with breast cancer in Northern Greece. (PubMed id 15837541)1, 4 Kalemi T.G....Kotsis A. (Cancer Lett. 2005)
    95. HER2 codon 655 polymorphism and breast cancer: results from kin-cohort and case-control analyses. (PubMed id 15754131)1, 4 Millikan R.C....Begg C.B. (Breast Cancer Res. Treat. 2005)
    96. A case-control study of the HER2 Ile655Val polymorphism in relation to risk of invasive breast cancer. (PubMed id 15987431)1, 4 Nelson S.E....Trentham-Dietz A. (Breast Cancer Res. 2005)
    97. Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor. (PubMed id 16314522)1, 2 Giri D.K.... Hung M.C. (Mol. Cell. Biol. 2005)
    98. Common ERBB2 polymorphisms and risk of breast cancer in a white British population: a case-control study. (PubMed id 15743501)1, 4 Benusiglio P.R....Ponder B.A. (Breast Cancer Res. 2005)
    99. Lung cancer: intragenic ERBB2 kinase mutations in tumours. (PubMed id 15457249)1, 2 Stephens P.... Stratton M.R. (Nature 2004)
    100. HER2 polymorphism and breast cancer risk in Portugal. (PubMed id 15167216)1, 4 Pinto D....Medeiros R. (Eur. J. Cancer Prev. 2004)
    101. Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2. (PubMed id 15210733)1, 2 Swiercz J.M.... Offermanns S. (J. Cell Biol. 2004)
    102. Memo mediates ErbB2-driven cell motility. (PubMed id 15156151)1, 2 Marone R.... Badache A. (Nat. Cell Biol. 2004)
    103. Ile to Val polymorphism at codon 655 of HER-2 gene and breast cancer risk in Iranian women. (PubMed id 15374636)1, 4 Kamali-Sarvestani E....Merat A. (Cancer Lett. 2004)
    104. Novel mode of ligand recognition by the Erbin PDZ domain. (PubMed id 12444095)1, 2 Birrane G.... Ladias J.A. (J. Biol. Chem. 2003)
    105. Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein. (PubMed id 12939402)1, 2 Li Y....Kufe D. (Mol. Cancer Res. 2003)
    106. The HER2 I655V polymorphism and risk of breast cancer in women &lt; age 40 years. (PubMed id 14578152)1, 4 Montgomery K.G....Campbell I.G. (amp 2003)
    107. HER2 codon 655 polymorphism and risk of breast cancer in African Americans and whites. (PubMed id 12846420)1, 4 Millikan R....Dressler L. (Breast Cancer Res. Treat. 2003)
    108. Distribution of HER2(V655) genotypes in breast cancer cases and controls in the United States. (PubMed id 11578807)1, 4 Keshava C....Weston A. (Cancer Lett. 2001)
    109. Germ-line HER-2 variant and breast cancer risk by stage of disease. (PubMed id 11731415)1, 4 McKean-Cowdin R....Henderson B.E. (Cancer Res. 2001)
    110. Vitamin D receptor and estrogen receptor gene polymorphisms in postmenopausal Danish women: no relation to bone markers or serum lipoproteins. (PubMed id 11910656)1, 4 Bagger Y.Z....Christiansen C. (Climacteric 2000)
    111. Re: population-based, case-control study of HER2 genetic polymorphism and breast cancer risk. (PubMed id 11106692)1, 4 Ameyaw M.M....McLeod H.L. (J. Natl. Cancer Inst. 2000)
    112. Poor binding of a HER-2/neu epitope (GP2) to HLA-A2.1 is due to a lack of interactions with the center of the peptide. (PubMed id 10593938)1, 2 Kuhns J.J.... Collins E.J. (J. Biol. Chem. 1999)
    113. Characterization of a new allele of the human ERBB2 gene by allele- specific competition hybridization. (PubMed id 8095488)1, 2 Ehsani A.... Wu A.M. (Genomics 1993)
    114. Molecular cloning and sequencing of an intron of Her-2/neu (ERBB2) gene. (PubMed id 8104414)1, 2 Sarkar F.H.... Crissman J.D. (DNA Cell Biol. 1993)
    115. Human HER2 (neu) promoter: evidence for multiple mechanisms for transcriptional initiation. (PubMed id 3039351)1, 2 Tal M.... Givol D. (Mol. Cell. Biol. 1987)
    116. Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. (PubMed id 3003577)1, 2 Yamamoto T.... Toyoshima K. (Nature 1986)
    117. A v-erbB-related protooncogene, c-erbB-2, is distinct from the c- erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma. (PubMed id 2995967)1, 2 Semba K.... Yamamoto T. (Proc. Natl. Acad. Sci. U.S.A. 1985)
    118. Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. (PubMed id 2999974)1, 2 Coussens L.... Ullrich A. (Science 1985)
    119. Amplification of a novel v-erbB-related gene in a human mammary carcinoma. (PubMed id 2992089)1, 2 King C.R.... Aaronson S.A. (Science 1985)
    120. Does HER2/neu expression provide prognostic information in patients with advanced urothelial carcinoma? (PubMed id 12209684)1, 9 Gandour-Edwards R....DeVere-White R. (Cancer 2002)
    121. Serum HER-2 concentrations for monitoring women with breast cancer in a routine oncology setting. (PubMed id 19728854)1, 9 SA...Brandslund I. (Clin. Chem. Lab. Med. 2009)
    122. Analysis of EGFR, HER2, and TOP2A gene status and chromosomal polysomy in gastric adenocarcinoma from Chinese patients. (PubMed id 19061514)1, 9 Liang Z....Liu T. (BMC Cancer 2008)
    123. [Expression of HER2/neu in meningiomas: an immunohistochemistry and fluorescence in situ hybridization study]. (PubMed id 20450760)1, 9 Wang C.L....Xiong Y.F. (Zhonghua Bing Li Xue Za Zhi 2010)
    124. HER-2 receptor expression, localization, and activation in colorectal cancer cell lines and human tumors. (PubMed id 14696118)1, 9 Half E....Sinicrope F.A. (Int. J. Cancer 2004)
    125. Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. (PubMed id 11071886)1, 9 Xu W....Neckers L. (J. Biol. Chem. 2001)
    126. Aberrations of ERBB2 and TOP2A genes in breast cancer. (PubMed id 19945923)1, 9 Nielsen K.V....Ejlertsen B. (Mol Oncol 2010)
    127. Pathology of borderline HER-2/neu breast carcinoma: a biologically distinct phenotype. (PubMed id 16538540)1, 9 Killeen J.L....Fu J.B. (Breast Cancer Res. Treat. 2006)
    128. Differential survival following trastuzumab treatment based on quantitative HER2 expression and HER2 homodimers in a clinic-based cohort of patients with metastatic breast cancer. (PubMed id 20178580)1, 9 Toi M....Bates M. (BMC Cancer 2010)
    129. Her-2/neu gene overexpression in breast carcinoma and its association with clinicopathological characteristics of the disease. (PubMed id 19409162)1, 9 Ahmad A....Khan A. (J Coll Physicians Surg Pak 2009)
    130. FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer. (PubMed id 19513552)1, 9 Francis R.E....Lam E.W. (Int. J. Oncol. 2009)
    131. Amplification of HER2 is a marker for global genomic instability. (PubMed id 18854030)1, 9 Ellsworth R.E....Shriver C.D. (BMC Cancer 2008)
    132. Quercetin-induced ubiquitination and down-regulation of Her-2/neu. (PubMed id 18655187)1, 9 Jeong J.H....Lee Y.J. (J. Cell. Biochem. 2008)
    133. Curcumin-induced degradation of ErbB2: A role for the E3 ubiquitin ligase CHIP and the Michael reaction acceptor activity of curcumin. (PubMed id 17239458)1, 9 Jung Y....Neckers L. (Biochim. Biophys. Acta 2007)
    134. Evaluation of HER-2 gene status in gastric carcinoma using immunohistochemistry, fluorescence in situ hybridization, and real-time quantitative polymerase chain reaction. (PubMed id 17555797)1, 9 Kim M.A....Kim W.H. (Hum. Pathol. 2007)
    135. HER2 gene status in primary breast cancers and matched distant metastases. (PubMed id 17511881)1, 9 Tapia C....Bubendorf L. (Breast Cancer Res. 2007)
    136. Clinical significance of the quantitative assessment of the cytosolic concentration of HER-2/neu protein in breast cancer by immunoenzymatic assay (ELISA). (PubMed id 16075281)1, 9 Corte M.D....Vizoso F.J. (J. Cancer Res. Clin. Oncol. 2005)
    137. ErbB2 degradation mediated by the co-chaperone protein CHIP. (PubMed id 12574167)1, 9 Zhou P....Band H. (J. Biol. Chem. 2003)
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    391. Diagnostic value of Her-2/neu, Cyfra 21-1, and carcinoembryonic antigen levels in malignant pleural effusions of lung adenocarcinoma. (PubMed id 20350214)1, 9 Huang W.W....Tseng C.E. (Pathology 2010)
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    394. Assessing HER2 gene amplification as a potential target for therapy in invasive urothelial bladder cancer with a standardized methodology: results in 1005 patients. (PubMed id 19889613)1, 9 LaAc M....Vieillefond A. (Ann. Oncol. 2010)
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    396. Interaction of syndecan and alpha6beta4 integrin cytoplasmic domains: regulation of ErbB2-mediated integrin activation. (PubMed id 20181947)1, 9 Wang H....Rapraeger A.C. (J. Biol. Chem. 2010)
    397. Epidermal growth factor receptor and HER-2/neu status by immunohistochemistry and fluorescence in situ hybridization in adenocarcinomas of the biliary tree and gallbladder. (PubMed id 20040392)1, 9 Shafizadeh N....Kakar S. (Hum. Pathol. 2010)
    398. Steroid receptors, HER2/neu and Ki-67, in endometrioid type of endometrial carcinoma: Correlation with conventional histomorphological features of prognosis. (PubMed id 19446313)1, 9 Chakravarty D....Dhaliwal L. (Acta Histochem. 2010)
    399. Shc is required for ErbB2-induced inhibition of apoptosis but is dispensable for cell proliferation and disruption of cell polarity. (PubMed id 19826412)1, 9 Lucs A.V....Muthuswamy S.K. (Oncogene 2010)
    400. Expression of p53, c-erbB-2 and Ki67 in intestinal metaplasia and gastric carcinoma. (PubMed id 20082479)1, 9 Zheng Y....Zhang X.Y. (World J. Gastroenterol. 2010)
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    402. Serum tumor necrosis factor-alpha and interleukin-2 concentrations in newly diagnosed ERBB2 (HER2/neu) positive breast cancer patients. (PubMed id 19787624)1, 9 Saglam S....Gurdol F. (Int. J. Biol. Markers 2009)
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    404. Nuclear Y-box binding protein-1, a predictive marker of prognosis, is correlated with expression of HER2/ErbB2 and HER3/ErbB3 in non-small cell lung cancer. (PubMed id 19648825)1, 9 Kashihara M....Ono M. (J Thorac Oncol 2009)
    405. HER-2/neu expression in extramammary Paget disease: a clinicopathologic and immunohistochemistry study of 47 cases with and without underlying malignancy. (PubMed id 19519604)1, 9 Plaza J.A....Prieto V.G. (J. Cutan. Pathol. 2009)
    406. Androgen receptor expression in prostate cancer cells is suppressed by activation of epidermal growth factor receptor and ErbB2. (PubMed id 19491261)1, 9 Cai C....Balk S.P. (Cancer Res. 2009)
    407. Involvement of the HER2 pathway in repair of DNA damage produced by chemotherapeutic agents. (PubMed id 19887555)1, 9 Boone J.J....Hochhauser D. (Mol. Cancer Ther. 2009)
    408. HER2/neu (c-erbB-2) gene amplification and protein expression are rare in uterine cervical neoplasia: a tissue microarray study of 814 archival specimens. (PubMed id 19775342)1, 9 Lesnikova I....Koch J. (APMIS 2009)
    409. Lack of elevated HER2/neu expression in epithelial dysplasia and oral squamous cell carcinoma in Iran. (PubMed id 19827890)1, 9 Seifi S....Ariaeifar B. (Asian Pac. J. Cancer Prev. 2009)
    410. Evaluation of gene amplification and protein expression of HER-2/neu in esophageal squamous cell carcinoma using Fluorescence in situ Hybridization (FISH) and immunohistochemistry. (PubMed id 19128465)1, 9 Sato-Kuwabara Y....Soares F.A. (BMC Cancer 2009)
    411. miR-331-3p regulates ERBB-2 expression and androgen receptor signaling in prostate cancer. (PubMed id 19584056)1, 9 Epis M.R....Leedman P.J. (J. Biol. Chem. 2009)
    412. Aberrant expression of proteinase-activated receptor 4 promotes colon cancer cell proliferation through a persistent signaling that involves Src and ErbB-2 kinase. (PubMed id 19058300)1, 9 Gratio V....Darmoul D. (Int. J. Cancer 2009)
    413. Oncoprotein HCCR-1 expression in breast cancer is well correlated with known breast cancer prognostic factors including the HER2 overexpression, p53 mutation, and ER/PR status. (PubMed id 19208263)1, 9 Ha S.A....Kim J.W. (BMC Cancer 2009)
    414. Increased expression of ErbB-2 in liver is associated with hepatitis B x antigen and shorter survival in patients with liver cancer. (PubMed id 19610068)1, 9 Liu J....Feitelson M.A. (Int. J. Cancer 2009)
    415. Osteoblast-induced EGFR/ERBB2 signaling in androgen-sensitive prostate carcinoma cells characterized by multiplex kinase activity profiling. (PubMed id 19294521)1, 9 Bratland A....Ree A.H. (amp 2009)
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    417. Status of HER1 and HER2 in peritoneal, ovarian and colorectal endometriosis and ovarian endometrioid adenocarcinoma. (PubMed id 19294416)1, 9 Uzan C....Vielh P. (Virchows Arch. 2009)
    418. Lapatinib, a dual EGFR and HER2 tyrosine kinase inhibitor, downregulates thymidylate synthase by inhibiting the nuclear translocation of EGFR and HER2. (PubMed id 19529774)1, 9 Kim H.P....Kim T.Y. (PLoS ONE 2009)
    419. Androgen receptor controls EGFR and ERBB2 gene expression at different levels in prostate cancer cell lines. (PubMed id 19318561)1, 9 Pignon J.C....Winkler R. (Cancer Res. 2009)
    420. HER family receptor abnormalities in lung cancer brain metastases and corresponding primary tumors. (PubMed id 19622585)1, 9 Sun M....Wistuba I.I. (Clin. Cancer Res. 2009)
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    422. Changes over time of extracellular domain of HER2 (ECD/HER2) serum levels have prognostic value in metastatic breast cancer. (PubMed id 18437556)1, 9 Bramwell V.H....Chambers A.F. (Breast Cancer Res. Treat. 2009)
    423. A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy. (PubMed id 18632642)1, 9 Lee-Hoeflich S.T....Stern H.M. (Cancer Res. 2008)
    424. Clinical pharmacology of trastuzumab. (PubMed id 18690878)7, 9 LevA-que D....Bergerat J.P. (Curr Clin Pharmacol 2008)
    425. EGFR and erbB2 in malignant peripheral nerve sheath tumors and implications for targeted therapy. (PubMed id 18650488)1, 9 Holtkamp N....von Deimling A. (Neuro-oncology 2008)
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    427. Prognostic significance of HER2 gene amplification according to stage of breast cancer. (PubMed id 18583876)1, 9 Kim Y.S....Park W.C. (J. Korean Med. Sci. 2008)
    428. Prolyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stability. (PubMed id 19077306)1, 9 Lam P.B....Wulf G.M. (Mol. Cancer 2008)
    429. Downregulation of HER2 by RIG1 involves the PI3K/Akt pathway in ovarian cancer cells. (PubMed id 18174256)1, 9 Ou C.C....Kao M.C. (Carcinogenesis 2008)
    430. The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11. (PubMed id 18724389)1, 9 Chen C.... Seth A.K. (Oncogene 2008)
    431. Luteinizing hormone-induced up-regulation of ErbB-2 is insufficient stimulant of growth and invasion in ovarian cancer cells. (PubMed id 19010824)1, 9 Warrenfeltz S.W....Puett D. (Mol. Cancer Res. 2008)
    432. MUC4 interacts with ErbB2 in human gallbladder carcinoma: potential pathobiological implications. (PubMed id 18397823)1, 9 Miyahara N....Irimura T. (Eur. J. Cancer 2008)
    433. Type 1 receptor tyrosine kinase profiles identify patients with enhanced benefit from anthracyclines in the BR9601 adjuvant breast cancer chemotherapy trial. (PubMed id 18768436)1, 9 Bartlett J.M....Twelves C.J. (J. Clin. Oncol. 2008)
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    435. Construction of a fully retargeted herpes simplex virus 1 recombinant capable of entering cells solely via human epidermal growth factor receptor 2. (PubMed id 18684832)1, 9 Menotti L....Campadelli-Fiume G. (J. Virol. 2008)
    436. A functionally significant cross-talk between androgen receptor and ErbB2 pathways in estrogen receptor negative breast cancer. (PubMed id 18516291)1, 9 Naderi A. and Hughes-Davies L. (Neoplasia 2008)
    437. Cyclooxygenase-2 predicts adverse effects of tamoxifen: a possible mechanism of role for nuclear HER2 in breast cancer patients. (PubMed id 18469157)1, 9 Dillon M.F....Young L.S. (Endocr. Relat. Cancer 2008)
    438. Impact of insulin-like growth factor type 1 receptor, epidermal growth factor receptor, and HER2 expressions on outcomes of patients with gastric cancer. (PubMed id 18483367)1, 9 Matsubara J....Shimoda T. (Clin. Cancer Res. 2008)
    439. Her-2/neu amplification and breast cancer survival: results from the Shanghai breast cancer study. (PubMed id 18425397)1, 9 Beeghly-Fadiel A....Zheng W. (Oncol. Rep. 2008)
    440. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. (PubMed id 18408761)1, 9 Li D....Wong K.K. (Oncogene 2008)
    441. Lapatinib: a dual inhibitor of human epidermal growth factor receptor tyrosine kinases. (PubMed id 18803986)7, 9 Medina P.J. and Goodin S. (Clin Ther 2008)
    442. HER-2/neu overexpression and amplification in uterine serous papillary carcinoma: comparative analysis of immunohistochemistry, real-time reverse transcription-polymerase chain reaction, and fluorescence in situ hybridization. (PubMed id 17451461)1, 9 Odicino F.E....Pecorelli S. (Int. J. Gynecol. Cancer 2008)
    443. Molecular characterisation of breast cancer patients at high and low recurrence risk. (PubMed id 18236071)1, 9 Bonin S....Stanta G. (Virchows Arch. 2008)
    444. HER-2/neu expression is associated with high tumor cell proliferation and aggressive phenotype in a population based patient series of endometrial carcinomas. (PubMed id 18202752)1, 9 Engelsen I.B....Salvesen H.B. (Int. J. Oncol. 2008)
    445. Serous carcinoma of the uterus-determination of HER-2/neu status using immunohistochemistry, chromogenic in situ hybridization, and quantitative polymerase chain reaction techniques: its significance and clinical correlation. (PubMed id 18248390)1, 9 Singh P....Davy M.L. (Int. J. Gynecol. Cancer 2008)
    446. MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells. (PubMed id 18381409)1, 9 Chaturvedi P....Batra S.K. (Cancer Res. 2008)
    447. Tubular carcinoma and grade 1 (well-differentiated) invasive ductal carcinoma: comparison of flat epithelial atypia and other intra-epithelial lesions. (PubMed id 18801081)1, 9 Kunju L.P....Kleer C.G. (Pathol. Int. 2008)
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    450. Could the truncated variant of ERBB2 be present in the squamous carcinomas of the cervix? (PubMed id 18818943)1, 9 Costa C....Alameda F. (Virchows Arch. 2008)
    451. HER2 status of bone marrow micrometastasis and their corresponding primary tumours in a pilot study of 27 cases: a possible tool for anti-HER2 therapy management? (PubMed id 17262082)1, 9 Vincent-Salomon A....Sastre-Garau X. (Br. J. Cancer 2007)
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    453. Low HER2-expressing glioblastomas are more often secondary to anaplastic transformation of low-grade glioma. (PubMed id 17571214)1, 9 Mineo J.F....Dam Hieu P. (J. Neurooncol. 2007)
    454. Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer. (PubMed id 17440164)1, 9 Scaltriti M....Baselga J. (J. Natl. Cancer Inst. 2007)
    455. Fhit expression protects against HER2-driven breast tumor development: unraveling the molecular interconnections. (PubMed id 17374991)1, 9 Bianchi F....Campiglio M. (Cell Cycle 2007)
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    457. Predominance of the basal type and HER-2/neu type in brain metastasis from breast cancer. (PubMed id 17541441)1, 9 Gaedcke J....Kreipe H.H. (Mod. Pathol. 2007)
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    460. Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells. (PubMed id 17631500)1, 9 Yoon S....Kim K.S. (J. Biol. Chem. 2007)
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    462. HER-2 tissue expression correlated with serum levels in breast cancer patients. (PubMed id 17706017)1, 9 PribylovA! O....Petruzelka L. (Folia Biol. (Praha) 2007)
    463. Non-small cell lung carcinoma: cyclin D1, bcl-2, p53, Ki-67 and HER-2 proteins expression in resected tumors. (PubMed id 17848143)1, 9 RadoviA8 S....SerdareviA8 F. (Bosn J Basic Med Sci 2007)
    464. p38MAPK-activated AKT in HER-2 overexpressing human breast cancer cells acts as an EGF-independent survival signal. (PubMed id 17612563)1, 9 Diehl K.M....Woods-Ignatoski K.M. (J. Surg. Res. 2007)
    465. HER2 expression as a potential marker for response to therapy targeted to the EGFR. (PubMed id 16622439)1, 9 Emlet D.R....Shackney S.E. (Br. J. Cancer 2006)
    466. Effects of HER2 overexpression on cell signaling networks governing proliferation and migration. (PubMed id 17016520)1, 9 Wolf-Yadlin A....White F.M. (Mol. Syst. Biol. 2006)
    467. HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. (PubMed id 16843263)1, 9 Wang S.E....Arteaga C.L. (Cancer Cell 2006)
    468. Alterations of the CCND1 and HER-2/neu (ERBB2) proteins in esophageal and gastric cancers. (PubMed id 16490596)1, 9 Bizari L....Silva A.E. (Cancer Genet. Cytogenet. 2006)
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    470. Over-expression of c-erbB-2 correlates with nuclear morphometry and prognosis in breast carcinoma in Asian women. (PubMed id 17393979)1, 9 Selvarajan S....Tan P.H. (Pathology 2006)
    471. Allelic imbalance of HER2 variant in sporadic breast and ovarian cancer. (PubMed id 16682283)1, 9 Puputti M....Nupponen N.N. (Cancer Genet. Cytogenet. 2006)
    472. A novel mutation in the tyrosine kinase domain of ERBB2 in hepatocellular carcinoma. (PubMed id 17150109)1, 9 Bekaii-Saab T....Eng C. (BMC Cancer 2006)
    473. Yin Yang 1 cooperates with activator protein 2 to stimulate ERBB2 gene expression in mammary cancer cells. (PubMed id 15870067)1, 9 Begon D.Y....Winkler R. (J. Biol. Chem. 2005)
    474. Integrin alpha6beta4-erbB2 complex inhibits haptotaxis by up-regulating E-cadherin cell-cell junctions in keratinocytes. (PubMed id 15579904)1, 9 Hintermann E....Quaranta V. (J. Biol. Chem. 2005)
    475. Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis. (PubMed id 15609325)1, 9 Beckers J....Seliger B. (Int. J. Cancer 2005)
    476. Zinc finger transcription factors designed for bispecific coregulation of ErbB2 and ErbB3 receptors: insights into ErbB receptor biology. (PubMed id 16199884)1, 9 Lund C.V....Barbas C.F. (Mol. Cell. Biol. 2005)
    477. Reorganization of ErbB family and cell survival signaling after Knock-down of ErbB2 in colon cancer cells. (PubMed id 15888451)1, 9 Hu Y.P....Brattain M.G. (J. Biol. Chem. 2005)
    478. Biomarker analysis in carcinoma ex pleomorphic adenoma at an early phase of carcinomatous transformation. (PubMed id 16273189)1, 9 Freitas L.L....Altemani A. (Int. J. Surg. Pathol. 2005)
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    480. A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. (PubMed id 15374980)7, 9 Wood E.R.... Shewchuk L. (Cancer Res. 2004)
    481. The ErbB2/Neu/HER2 receptor is a new calmodulin-binding protein. (PubMed id 15080792)1, 9 Li H....Villalobo A. (Biochem. J. 2004)
    482. HER-2/neu overexpression increases the viable hypoxic cell population within solid tumors without causing changes in tumor vascularization. (PubMed id 15561777)1, 9 Dragowska W.H....Bally M.B. (Mol. Cancer Res. 2004)
    483. Genetic and pathologic significance of 1p, 17p, and 18q aneusomy and the ERBB2 gene in colorectal cancer and related normal colonic mucosa. (PubMed id 15120910)1, 9 Cianciulli A....Guadagni F. (Cancer Genet. Cytogenet. 2004)
    484. Expression of c-erbB receptors, MMPs and VEGF in squamous cell carcinoma of the head and neck. (PubMed id 15254682)1, 9 Do N.Y....Im T.S. (Oncol. Rep. 2004)
    485. Clinical relevance of HER-2/neu expression in germ-cell testicular tumors. (PubMed id 15330164)1, 9 MA!ndoky L....Bak M. (Anticancer Res. 2004)
    486. Emerging role of epidermal growth factor receptor inhibition in therapy for advanced malignancy: focus on NSCLC. (PubMed id 14967461)7, 9 Langer C.J. (Int. J. Radiat. Oncol. Biol. Phys. 2004)
    487. Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. (PubMed id 15235125)1, 9 Menendez J.A....Lupu R. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    488. Role of ErbB2 in Corneal Epithelial Wound Healing. (PubMed id 15557433)1, 9 Xu K.P....Yu F.S. (amp 2004)
    489. E6/E7 proteins of HPV type 16 and ErbB-2 cooperate to induce neoplastic transformation of primary normal oral epithelial cells. (PubMed id 14724563)1, 9 Al Moustafa A.E....Alaoui-Jamali M.A. (Oncogene 2004)
    490. Cytoplasmic p21WAF1/CIP1 expression is correlated with HER-2/ neu in breast cancer and is an independent predictor of prognosis. (PubMed id 14580260)1, 9 Winters Z.E....Harris A.L. (Breast Cancer Res. 2003)
    491. Quantitative association between HER-2/neu and steroid hormone receptors in hormone receptor-positive primary breast cancer. (PubMed id 12529347)1, 9 Konecny G....Slamon D.J. (J. Natl. Cancer Inst. 2003)
    492. EGFR, HER-2/neu, cyclin D1, p21 and p53 in correlation to cell proliferation and steroid hormone receptor status in ductal carcinoma in situ of the breast. (PubMed id 12825853)1, 9 Lebeau A....LAPhrs U. (Breast Cancer Res. Treat. 2003)
    493. Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation. (PubMed id 12775708)1, 9 Martin L.A....Dowsett M. (J. Biol. Chem. 2003)
    494. Identification of ErbB-2 kinase domain motifs required for geldanamycin-induced degradation. (PubMed id 12517775)1, 9 Tikhomirov O. and Carpenter G. (Cancer Res. 2003)
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    496. ERBB2 up-regulates S100A4 and several other prometastatic genes in medulloblastoma. (PubMed id 12517790)1, 9 Hernan R....Gilbertson R.J. (Cancer Res. 2003)
    497. Prognostic role of apoptotic, Bcl-2, c-erbB-2 and p53 tumor markers in salivary gland malignancies. (PubMed id 12759537)1, 9 Nagler R.M....Ben-Itzhak O. (Oncology 2003)
    498. HER2/neu overexpression in the development of muscle-invasive transitional cell carcinoma of the bladder. (PubMed id 14520464)1, 9 Latif Z....Bartlett J.M. (Br. J. Cancer 2003)
    499. Detection of urokinase plasminogen activator receptor and c-erbB-2 in sera of patients with breast and ovarian carcinoma. (PubMed id 14563447)1, 9 Mabrouk R.A. and Ali-Labib R. (Clin. Biochem. 2003)
    500. Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis. (PubMed id 12517789)1, 9 Kumar-Sinha C....Chinnaiyan A.M. (Cancer Res. 2003)
    501. Comparison of differential PCR and immunohistochemistry for the evaluation of c-erbB-2 in breast carcinoma and relationship to other prognostic factors. (PubMed id 14628084)1, 9 Erdogan S....Tuncer I. (Neoplasma 2003)
    502. ErbB2 overexpression in an ovarian cancer cell line confers sensitivity to the HSP90 inhibitor geldanamycin. (PubMed id 12174876)1, 9 Smith V....Kelland L.R. (Anticancer Res. 2002)
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    505. Bombesin antagonists inhibit growth of MDA-MB-435 estrogen-independent breast cancers and decrease the expression of the ErbB-2/HER-2 oncoprotein and c-jun and c-fos oncogenes. (PubMed id 11891317)1, 9 Bajo A.M....Szepeshazi K. (Proc. Natl. Acad. Sci. U.S.A. 2002)
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    518. Assignment of v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2) to human chromosome band 17q21.1 by in situ hybridization. (PubMed id 9154120)1, 9 Muleris M....Dutrillaux B. (Cytogenet. Cell Genet. 1997)
    519. Prognostic value of HER-2/neu expression in epithelial ovarian cancer: a meta-analysis. (PubMed id 23873100)1 Wang Y....Ren M. (Tumour Biol. 2014)
    520. Liver kinase B1 expression promotes phosphatase activity and abrogation of receptor tyrosine kinase phosphorylation in human cancer cells. (PubMed id 24285539)1 Okon I.S....Zou M.H. (J. Biol. Chem. 2014)
    521. A meta-analysis of oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 discordance between primary breast cancer and metastases. (PubMed id 24269135)1 Aurilio G....NolA" F. (Eur. J. Cancer 2014)
    522. Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas. (PubMed id 24317180)1 Yamamoto H....Toyooka S. (J. Natl. Cancer Inst. 2014)
    523. Phase I study of neratinib in combination with temsirolimus in patients with human epidermal growth factor receptor 2-dependent and other solid tumors. (PubMed id 24323026)1 Gandhi L....Soria J.C. (J. Clin. Oncol. 2014)
    524. Tyrosine phosphatase PTPI+ contributes to HER2-evoked breast tumor initiation and maintenance. (PubMed id 23318421)1 Meyer D.S....Bentires-Alj M. (Oncogene 2014)
    525. Association analysis of ERBB2 amplicon genetic polymorphisms and STARD3 expression with risk of gastric cancer in the Chinese population. (PubMed id 24291029)1 Qiu Y....Zhang X.J. (Gene 2014)
    526. HER2 gene copy number status may influence clinical efficacy to anti-EGFR monoclonal antibodies in metastatic colorectal cancer patients. (PubMed id 23348520)1 Martin V....Cappuzzo F. (Br. J. Cancer 2013)
    527. HER2 stabilizes EGFR and itself by altering autophosphorylation patterns in a manner that overcomes regulatory mechanisms and promotes proliferative and transformation signaling. (PubMed id 23027125)1 Hartman Z....Agazie Y.M. (Oncogene 2013)
    528. Level of HER2/neu amplification in primary tumours and metastases in HER2-positive breast cancer and survival after trastuzumab therapy. (PubMed id 23473771)1 Gullo G....Santoro A. (Breast 2013)
    529. The receptor attachment function of measles virus hemagglutinin can be replaced with an autonomous protein that binds Her2/neu while maintaining its fusion-helper function. (PubMed id 23536664)1 Rasbach A....Buchholz C.J. (J. Virol. 2013)
    530. Evaluation of changes of biologic markers ER, PR, HER 2 and Ki-67 in breast cancer with administration of neoadjuvant dose-dense doxorubicin, cyclophosphamide followed by paclitaxel. (PubMed id 23613389)1 Dede D.S....Ozisik Y. (J BUON 2013)
    531. Stability of the recombinant antia89erbB2 scFva89Fca89interleukina892 fusion protein and its inhibition of HER2a89overexpressing tumor cells. (PubMed id 23258564)1 Du Y.J....Wang C.Z. (Int. J. Oncol. 2013)
    532. HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: implications for efficacy of adjuvant trastuzumab. (PubMed id 23442322)1 Ithimakin S....Wicha M.S. (Cancer Res. 2013)
    533. Non-small-cell lung cancer with HER2 exon 20 mutation: regression with dual HER2 inhibition and anti-VEGF combination treatment. (PubMed id 23328556)1 Falchook G.S....Kurzrock R. (J Thorac Oncol 2013)
    534. Junctional adhesion molecule-A is co-expressed with HER2 in breast tumors and acts as a novel regulator of HER2 protein degradation and signaling. (PubMed id 22751120)1 Brennan K....Hopkins A.M. (Oncogene 2013)
    535. Expression of Eag1 K+ channel and ErbBs in human pituitary adenomas: cytoskeleton arrangement patterns in cultured cells. (PubMed id 23413122)1 del Pliego M.G....Mendoza-Garrido M.E. (Int J Clin Exp Pathol 2013)
    536. Diagnostic value of tumor markers in lung adenocarcinoma-associated cytologically negative pleural effusions. (PubMed id 23408492)1 Hsieh T.C....Su C.C. (Cancer Cytopathol 2013)
    537. Assessment of HER2 gene amplification in adenocarcinomas of the stomach or gastroesophageal junction in the INT-0116/SWOG9008 clinical trial. (PubMed id 23524864)1 Gordon M.A....Press M.F. (Ann. Oncol. 2013)
    538. Her2 amplification distinguishes a subset of non-muscle-invasive bladder cancers with a high risk of progression. (PubMed id 23087329)1 Chen P.C....Pan C.C. (J. Clin. Pathol. 2013)
    539. &quot;Omics&quot; of HER2-positive breast cancer. (PubMed id 23421906)1 BravatA V....Minafra L. (OMICS 2013)
    540. Expression and potential role of ErbB receptors in type II endometrial cancer. (PubMed id 23395558)1 Androutsopoulos G....Decavalas G. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2013)
    541. HER2 in gastric cancer: a digital image analysis in pre-neoplastic, primary and metastatic lesions. (PubMed id 23348899)1 Fusco N....Bosari S. (Mod. Pathol. 2013)
    542. Discordances in estrogen receptor status, progesterone receptor status, and HER2 status between primary breast cancer and metastasis. (PubMed id 23723333)1 Curtit E....Pivot X. (Oncologist 2013)
    543. Unbiased quantitative assessment of Her-2 expression of circulating tumor cells in patients with metastatic and non-metastatic breast cancer. (PubMed id 23275633)1 Ligthart S.T....Terstappen L.W. (Ann. Oncol. 2013)
    544. Frequent genetic alterations in EGFR- and HER2-driven pathways in breast cancer brain metastases. (PubMed id 23665199)1 Hohensee I....Wikman H. (Am. J. Pathol. 2013)
    545. MiR-199b-5p targets HER2 in breast cancer cells. (PubMed id 23296799)1 Fang C....Guo B. (J. Cell. Biochem. 2013)
    546. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    547. Flotillin2 expression correlates with HER2 levels and poor prognosis in gastric cancer. (PubMed id 23658725)1 Zhu Z....Xu H. (PLoS ONE 2013)
    548. Potential advantages of CUDC-101, a multitargeted HDAC, EGFR, and HER2 inhibitor, in treating drug resistance and preventing cancer cell migration and invasion. (PubMed id 23536719)1 Wang J....Lai C.J. (Mol. Cancer Ther. 2013)
    549. CDK inhibitor p57 (Kip2) is downregulated by Akt during HER2-mediated tumorigenicity. (PubMed id 23421998)1 Zhao R....Lee M.H. (Cell Cycle 2013)
    550. Correlation of HER2, FCGR2A, and FCGR3A gene polymorphisms with trastuzumab related cardiac toxicity and efficacy in a subgroup of patients from UNICANCER-PACS 04 trial. (PubMed id 23780683)1 Roca L....de Cremoux P. (Breast Cancer Res. Treat. 2013)
    551. Dynamic analysis of the epidermal growth factor (EGF) receptor-ErbB2-ErbB3 protein network by luciferase fragment complementation imaging. (PubMed id 24014028)1 Macdonald-Obermann J.L....Pike L.J. (J. Biol. Chem. 2013)
    552. Pertuzumab for the treatment of human epidermal growth factor receptor type 2-positive metastatic breast cancer. (PubMed id 23988598)1 Chung C. and Lam M.S. (Am J Health Syst Pharm 2013)
    553. PTEN, Akt, MAPK, p53 and p95 expression to predict trastuzumab resistance in HER2 positive breast cancer. (PubMed id 23613387)1 Duman B.B....Zorludemir S. (J BUON 2013)
    554. The role of ThinPrep cytology in the investigation of ki-67 index, p53 and HER-2 detection in fine-needle aspirates of breast tumors. (PubMed id 23818345)1 Konofaos P....Karakitsos P. (J BUON 2013)
    555. Polymorphic Ala-allele carriers at residue 1170 of HER2 associated with Parkinson's disease. (PubMed id 23332978)1 Wang V....Shieh T.M. (J. Neurol. Sci. 2013)
    556. Efficient downregulation of ErbB-2 induces TACC1 upregulation in breast cancer cell lines. (PubMed id 23354013)1 Xiang J....Yue L. (Oncol. Rep. 2013)
    557. A complex containing LPP and I+-actinin mediates TGFI^-induced migration and invasion of ErbB2-expressing breast cancer cells. (PubMed id 23447672)1 Ngan E....Siegel P.M. (J. Cell. Sci. 2013)
    558. Analysis of conformational determinants underlying HSP90-kinase interaction. (PubMed id 23844194)1 Kancha R.K....Duyster J. (PLoS ONE 2013)
    559. HER2 expression and its clinicopathological features in resectable gastric cancer. (PubMed id 22410801)1 Kataoka Y....Sakai Y. (Gastric Cancer 2013)
    560. Clinical role of HER-2/neu expression in colorectal cancer. (PubMed id 23613394)1 Pappas A....Manouras A. (J BUON 2013)
    561. Prognostic significance of estrogen receptor, progesterone receptor, HER2/neu, Ki-67, and nm23 expression in patients with invasive breast cancer. (PubMed id 23818346)1 Cubukcu E....Manavoglu O. (J BUON 2013)
    562. HER2 amplification in squamous cell carcinomas of the vulva. (PubMed id 23444903)1 Choschzick M....Sauter G. (Histopathology 2013)
    563. The HER2-miR125a5p/miR125b loop in gastric and esophageal carcinogenesis. (PubMed id 23618359)1 Fassan M....Rugge M. (Hum. Pathol. 2013)
    564. The prognostic significance of p21 and Her-2 gene expression and mutation/polymorphism in patients with gastric adenocarcinoma. (PubMed id 23275116)1 Ozen A....Karagol H. (Med. Oncol. 2013)
    565. Capecitabine/cisplatin doublet in anthracycline and taxane pretreated and HER-2 negative metastatic breast carcinoma patients. (PubMed id 24344005)1 Ozdemir N....Zengin N. (J BUON 2013)
    566. Quantitative detection of HER2 protein concentration in breast cancer tissue does not increase the number of patients eligible for adjuvant HER2-targeted therapy. (PubMed id 23417164)1 Bechmann T....Jakobsen A. (Oncol. Rep. 2013)
    567. Effects of ectopic HER-2/neu gene expression on the COX-2/PGE2/P450arom signaling pathway in endometrial carcinoma cells: HER-2/neu gene expression in endometrial carcinoma cells. (PubMed id 23453006)1 Li S....Yu Z. (amp 2013)
    568. Epigenetic modulation of signal transduction pathways in HPV-associated HNSCC. (PubMed id 23736812)1 Worsham M.J....Divine G. (Otolaryngol Head Neck Surg 2013)
    569. Definition of p53 overexpression and its association with the clinicopathological features in luminal/HER2-negative breast cancer. (PubMed id 24023325)1 Kikuchi S....Arima N. (Anticancer Res. 2013)
    570. Heregulin induces resistance to lapatinib-mediated growth inhibition of HER2-amplified cancer cells. (PubMed id 24112719)1 Sato Y....Takakura N. (Cancer Sci. 2013)
    571. Metformin inhibits proliferation and promotes apoptosis of HER2 positive breast cancer cells by downregulating HSP90. (PubMed id 23613388)1 Chen T.W....Kong H. (J BUON 2013)
    572. MET and ERBB2 are coexpressed in ERBB2+ breast cancer and contribute to innate resistance. (PubMed id 23825050)1 Paulson A.K....Graveel C.R. (Mol. Cancer Res. 2013)
    573. HER2 expression in Brazilian patients with estrogen and progesterone receptor-negative breast carcinoma. (PubMed id 22647460)1 Ramalho S....de Souza G. (Acta Histochem. 2013)
    574. Autocrine motility factor promotes HER2 cleavage and signaling in breast cancer cells. (PubMed id 23248119)1 Kho D.H....Raz A. (Cancer Res. 2013)
    575. An ERBB3/ERBB2 oncogenic unit plays a key role in NRG1 signaling and melanoma cell growth and survival. (PubMed id 23480537)1 Zhang K....Bedogni B. (amp 2013)
    576. Pertuzumab counteracts the inhibitory effect of ErbB2 on degradation of ErbB3. (PubMed id 23698633)1 Sak M.M....Stang E. (Carcinogenesis 2013)
    577. ErbB2-dependent chemotaxis requires microtubule capture and stabilization coordinated by distinct signaling pathways. (PubMed id 23383112)1 Benseddik K....Badache A. (PLoS ONE 2013)
    578. Targeting the human epidermal growth factor receptor 2 in esophageal cancer. (PubMed id 23571701)1 Almhanna K....Coppola D. (Cancer Control 2013)
    579. Immunohistochemical expression of ErbB2 in adamantinomatous craniopharyngiomas: a possible target for immunotherapy. (PubMed id 23344868)1 Zuhur S.S....Altuntas Y. (Turk Neurosurg 2013)
    580. [Expression of HER2 in smoking gastric cancer patients--is it possible?]. (PubMed id 24501797)1 Bodnar M....MarszaA8lek A. (Prz. Lek. 2013)
    581. Differences in HER2 over-expression between proximal and distal gastric cancers in the Chinese population. (PubMed id 23745034)1 Fan X.S....Huang Q. (World J. Gastroenterol. 2013)
    582. Comparison of fluorescence in situ hybridization (FISH) and dual-ISH (DISH) in the determination of HER2 status in breast cancer. (PubMed id 23355198)1 Mansfield A.S....Jenkins R.B. (Am. J. Clin. Pathol. 2013)
    583. ErbB2, ErbB3 and ErbB4 expression in urothelial tumors of the upper urinary tract and their prognostic significance. (PubMed id 24065479)1 Galanakis I....Mitropoulos D. (J BUON 2013)
    584. Genetic alterations of K-ras, p53, c-erbB-2, and DPC4 in pancreatic ductal adenocarcinoma and their correlation with patient survival. (PubMed id 23344532)1 Shin S.H....Lee Y.J. (Pancreas 2013)
    585. HER2 Ile655Val and PTEN IVS4 polymorphisms in patients with breast cancer. (PubMed id 23086302)1 Ozturk O....Uras C. (Mol. Biol. Rep. 2013)
    586. Serum HER-2: sensitivity, specificity, and predictive values for detecting metastatic recurrence in breast cancer patients. (PubMed id 23483255)1 SA...Brandslund I. (J. Cancer Res. Clin. Oncol. 2013)
    587. Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis. (PubMed id 23592719)1 Laurin M....CA'tAc J.F. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    588. Gene amplification and immunohistochemical expression of ERBB2 and EGFR in cervical carcinogenesis. Correlation with cell-cycle markers and HPV presence. (PubMed id 23827764)1 Conesa-Zamora P....PAcrez-Guillermo M. (Exp. Mol. Pathol. 2013)
    589. HER2/neu expression correlates with vasculogenic mimicry in invasive breast carcinoma. (PubMed id 23279650)1 Liu T....Ma Y. (J. Cell. Mol. Med. 2013)
    590. The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells. (PubMed id 23253899)1 Sahlberg K.K....Kallioniemi O. (Mol Oncol 2013)
    591. Evaluation of changes in biologic markers ER, PR, HER 2 and Ki-67 index in breast cancer with administration of neoadjuvant dose dense doxorubicin, cyclophosphamide followed by paclitaxel chemotherapy. (PubMed id 23818347)1 Dede D.S....Ozisik Y. (J BUON 2013)
    592. Amplification of the human epidermal growth factor receptor 2 gene in differentiated thyroid cancer correlates with telomere shortening. (PubMed id 23467725)1 Sugishita Y....Yamada T. (Int. J. Oncol. 2013)
    593. Brk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transition. (PubMed id 23291984)1 Ai M....Fan Z. (amp 2013)
    594. Carboxyl group footprinting mass spectrometry and molecular dynamics identify key interactions in the HER2-HER3 receptor tyrosine kinase interface. (PubMed id 23843458)1 Collier T.S....Bose R. (J. Biol. Chem. 2013)
    595. Constitutive HER2 signaling promotes breast cancer metastasis through cellular senescence. (PubMed id 23288917)1 Angelini P.D....Arribas J. (Cancer Res. 2013)
    596. Change in HER2 (ERBB2) gene status after taxane-based chemotherapy for breast cancer: polyploidization can lead to diagnostic pitfalls with potential impact for clinical management. (PubMed id 23313108)1 Valent A....Kroemer G. (Cancer Genet 2013)
    597. Adaptor protein complex of FRS2I^ and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation. (PubMed id 23279575)1 Minegishi Y....Gotoh N. (Cancer Sci. 2013)
    598. Effect of androgen blockade on HER-2 and matrix metalloproteinase-2 expression on bone marrow micrometastasis and stromal cells in men with prostate cancer. (PubMed id 23766685)1 Murray N.P....DueA+as R. (ScientificWorldJournal 2013)
    599. The impact of genomic changes on treatment of lung cancer. (PubMed id 23841470)1 Cardarella S. and Johnson B.E. (Am. J. Respir. Crit. Care Med. 2013)
    600. Clinical significance of intratumoral HER2 heterogeneity in gastric cancer. (PubMed id 23146959)1 Lee H.E....Lee H.S. (Eur. J. Cancer 2013)
    601. HER2 protein expression and HER2 gene amplification are infrequent in small intestinal carcinomas. (PubMed id 23703294)1 Gu M.J....Jung S.J. (Virchows Arch. 2013)
    602. Negative transcriptional control of ERBB2 gene by MBP-1 and HDAC1: diagnostic implications in breast cancer. (PubMed id 23421821)1 Contino F....Feo S. (BMC Cancer 2013)
    603. Correlation of human epidermal growth factor receptor 2 expression with clinicopathological characteristics and prognosis in gastric cancer. (PubMed id 23599643)1 He C....Liu Q. (World J. Gastroenterol. 2013)
    604. HER2 stabilizes survivin while concomitantly down-regulating survivin gene transcription by suppressing Notch cleavage. (PubMed id 23323858)1 Ju J.H....Shin I. (Biochem. J. 2013)
    605. Lapatinib as a component of neoadjuvant therapy for HER2-positive operable breast cancer (NSABP protocol B-41): an open-label, randomised phase 3 trial. (PubMed id 24095300)1 Robidoux A....Wolmark N. (Lancet Oncol. 2013)
    606. ErbB receptor tyrosine kinase family expression levels in urothelial bladder carcinoma. (PubMed id 23333248)1 Gunes S....Bagci H. (Pathol. Res. Pract. 2013)
    607. Alcohol and HER2 polymorphisms as risk factor for cardiotoxicity in breast cancer treated with trastuzumab. (PubMed id 23749910)1 Lemieux J....Laflamme C. (Anticancer Res. 2013)
    608. Interaction between Her2 and Beclin-1 proteins underlies a new mechanism of reciprocal regulation. (PubMed id 23703612)1 Han J....Rabinowich H. (J. Biol. Chem. 2013)
    609. Comedo-DCIS is a precursor lesion for basal-like breast carcinoma: identification of a novel p63/Her2/neu expressing subgroup. (PubMed id 23548208)1 Shekhar M.P....Tait L. (Oncotarget 2013)
    610. Acquired substrate preference for GAB1 protein bestows transforming activity to ERBB2 kinase lung cancer mutants. (PubMed id 23612964)1 Fan Y.X....Johnson G.R. (J. Biol. Chem. 2013)
    611. In situ analysis of HER2 mRNA in gastric carcinoma: comparison with fluorescence in situ hybridization, dual-color silver in situ hybridization, and immunohistochemistry. (PubMed id 23084583)1 Kim M.A....Kim W.H. (Hum. Pathol. 2013)
    612. Clinical usefulness of human epidermal growth factor receptor-2 extracellular domain as a biomarker for monitoring cancer status and predicting the therapeutic efficacy in breast cancer. (PubMed id 23114645)1 Kontani K....Yokomise H. (amp 2013)
    613. Mammary tumor formation and metastasis evoked by a HER2 splice variant. (PubMed id 23867476)1 Alajati A....Bentires-Alj M. (Cancer Res. 2013)
    614. Noninvasive detection of HER2 amplification with plasma DNA digital PCR. (PubMed id 23637122)1 Gevensleben H....Turner N.C. (Clin. Cancer Res. 2013)
    615. The HER2 status of disseminated tumor cells in the bone marrow of early breast cancer patients is independent from primary tumor and predicts higher risk of relapse. (PubMed id 23494674)1 Hartkopf A.D....Fehm T. (Breast Cancer Res. Treat. 2013)
    616. Significance of TFF3 protein and Her-2/neu status in patients with gastric adenocarcinoma. (PubMed id 23822993)1 Xu C.C....Qiu W.S. (Pathol. Res. Pract. 2013)
    617. Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutations. (PubMed id 23575477)1 Ross J.S....Stephens P.J. (Clin. Cancer Res. 2013)
    618. Serum HER 2 extracellular domain level is correlated with tissue HER 2 status in metastatic gastric or gastro-oesophageal junction adenocarcinoma. (PubMed id 23691049)1 Dai S.Q....Li Y.H. (PLoS ONE 2013)
    619. The HSP90 inhibitor geldanamycin perturbs endosomal structure and drives recycling ErbB2 and transferrin to modified MVBs/lysosomal compartments. (PubMed id 23154999)1 Cortese K....Tacchetti C. (Mol. Biol. Cell 2013)
    620. Discordance in HER2 gene amplification in circulating and disseminated tumor cells in patients with operable breast cancer. (PubMed id 23634290)1 Krishnamurthy S....Lucci A. (Cancer Med 2013)
    621. Absence of human papillomavirus infection and activation of PI3K-AKT pathway in cervical clear cell carcinoma. (PubMed id 23792604)1 Ueno S....Nishimura R. (Int. J. Gynecol. Cancer 2013)
    622. Outcome impact of PIK3CA mutations in HER2-positive breast cancer patients treated with trastuzumab. (PubMed id 23612454)1 Cizkova M....Bieche I. (Br. J. Cancer 2013)
    623. WNT10B/I^-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer. (PubMed id 23307470)1 Wend P....Miranda-Carboni G.A. (EMBO Mol Med 2013)
    624. Left ventricular systolic function in HER2/neu negative breast cancer patients treated with anthracycline chemotherapy: a comparative analysis of left ventricular ejection fraction and myocardial strain imaging over 12 months. (PubMed id 23937961)1 Stoodley P.W....Thomas L. (Eur. J. Cancer 2013)
    625. HER1 R497K and HER2 I655V polymorphisms are linked to development of breast cancer. (PubMed id 23594562)1 AbdRaboh N.R....Bayoumi F.A. (Dis. Markers 2013)
    626. RNA-based determination of ESR1 and HER2 expression and response to neoadjuvant chemotherapy. (PubMed id 23131391)1 Denkert C....von Minckwitz G. (Ann. Oncol. 2013)
    627. Molecular characterization of mucinous ovarian tumours supports a stratified treatment approach with HER2 targeting in 19% of carcinomas. (PubMed id 22899400)1 Anglesio M.S....McAlpine J.N. (J. Pathol. 2013)
    628. HER2 expression and relevant clinicopathological features in gastric and gastroesophageal junction adenocarcinoma in a Chinese population. (PubMed id 23656792)1 Shan L....Lu N. (Diagn Pathol 2013)
    629. Clinical significance of vimentin expression and Her-2 status in patients with gastric carcinoma. (PubMed id 23751022)1 Zhao W....Qiu W. (Clin Transl Sci 2013)
    630. Flotillins as regulators of ErbB2 levels in breast cancer. (PubMed id 22869152)1 Pust S....Sandvig K. (Oncogene 2013)
    631. Her2neu amplification associates with Co-deletion 1p/14q in recurrent meningiomas. (PubMed id 23603172)1 Hamilton B.O....Ang L.C. (Can J Neurol Sci 2013)
    632. Identification of relevant conformational epitopes on the HER2 oncoprotein by using Large Fragment Phage Display (LFPD). (PubMed id 23555577)1 Gabrielli F....Amici A. (PLoS ONE 2013)
    633. Loss of fatty acid synthase inhibits the &quot;HER2-PI3K/Akt axis&quot; activity and malignant phenotype of Caco-2 cells. (PubMed id 23725225)1 Li N....Huang P. (Lipids Health Dis 2013)
    634. Flavopiridol synergizes with sorafenib to induce cytotoxicity and potentiate antitumorigenic activity in EGFR/HER-2 and mutant RAS/RAF breast cancer model systems. (PubMed id 23908594)1 Nagaria T.S....Sangrar W. (Neoplasia 2013)
    635. MUC1 and HER2 might be associated with invasive phenotype of intraductal papillary mucinous neoplasm. (PubMed id 23635475)1 Ohira G....Hirakawa K. (Hepatogastroenterology 2013)
    636. Level of HER2 gene amplification predicts response and overall survival in HER2-positive advanced gastric cancer treated with trastuzumab. (PubMed id 24127447)1 Gomez-Martin C....Lopez-Rios F. (J. Clin. Oncol. 2013)
    637. HER2 mediates epidermal growth factor-induced down-regulation of E-cadherin in human ovarian cancer cells. (PubMed id 23542467)1 Cheng J.C....Leung P.C. (Biochem. Biophys. Res. Commun. 2013)
    638. Correlation of phosphorylated HER2 with clinicopathological characteristics and efficacy of trastuzumab treatment for breast cancer. (PubMed id 23749902)1 RamiA8 S....KneA3eviA8 F. (Anticancer Res. 2013)
    639. Racially restricted contribution of immunoglobulin FcI^ and FcI^ receptor genotypes to humoral immunity to human epidermal growth factor receptor 2 in breast cancer. (PubMed id 23379433)1 Pandey J.P....Tsugane S. (Clin. Exp. Immunol. 2013)
    640. Increased hyaluronan content and stromal cell CD44 associate with HER2 positivity and poor prognosis in human breast cancer. (PubMed id 22753277)1 Auvinen P....Tammi M. (Int. J. Cancer 2013)
    641. HER2 regulates Brk/PTK6 stability via upregulating calpastatin, an inhibitor of calpain. (PubMed id 23707532)1 Ai M....Fan Z. (Cell. Signal. 2013)
    642. Preubiquitinated chimeric ErbB2 is constitutively endocytosed and subsequently degraded in lysosomes. (PubMed id 23127513)1 Vuong T.T....Madshus I.H. (Exp. Cell Res. 2013)
    643. The detection of ESR1/PGR/ERBB2 mRNA levels by RT-QPCR: a better approach for subtyping breast cancer and predicting prognosis. (PubMed id 23397283)1 Du X....Feng Y.M. (Breast Cancer Res. Treat. 2013)
    644. The growth factor receptor ERBB2 regulates mitochondrial activity on a signaling time scale. (PubMed id 24142693)1 Patel N....Landgraf R. (J. Biol. Chem. 2013)
    645. Tissue aluminum concentration does not affect the genomic stability of ERBB2, C-MYC, and CCND1 genes in breast cancer. (PubMed id 23861098)1 Rodrigues-Peres R.M....Sarian L.O. (Biol Trace Elem Res 2013)
    646. The predictive and prognostic significance of pre- and post-treatment topoisomerase III+ in anthracycline-based neoadjuvant chemotherapy for local advanced breast cancer. (PubMed id 23473851)1 Chen S....Shao Z.M. (Eur J Surg Oncol 2013)
    647. Reduction of the ST6 I^-galactosamide I+-2,6-sialyltransferase 1 (ST6GAL1)-catalyzed sialylation of nectin-like molecule 2/cell adhesion molecule 1 and enhancement of ErbB2/ErbB3 signaling by microRNA-199a. (PubMed id 23504322)1 Minami A....Takai Y. (J. Biol. Chem. 2013)
    648. Plasma HER2 amplification in cell-free DNA during neoadjuvant chemotherapy in breast cancer. (PubMed id 23479212)1 Bechmann T....Jakobsen A. (J. Cancer Res. Clin. Oncol. 2013)
    649. Discordant HER2 status between primary breast carcinoma and recurrent/metastatic tumors using fluorescence in situ hybridization on cytological samples. (PubMed id 23225912)1 Arihiro K....Taira Y. (Jpn. J. Clin. Oncol. 2013)
    650. The significance of the HER-2 status in esophageal adenocarcinoma for survival: an immunohistochemical and an in situ hybridization study. (PubMed id 23334118)1 Prins M.J....Ten Kate F.J. (Ann. Oncol. 2013)
    651. A dominant-negative N-terminal fragment of HER2 frequently expressed in breast cancers. (PubMed id 22641219)1 Morancho B....Arribas J. (Oncogene 2013)
    652. CDC25A protein stability represents a previously unrecognized target of HER2 signaling in human breast cancer: implication for a potential clinical relevance in trastuzumab treatment. (PubMed id 23730206)1 Brunetto E....Cangi M.G. (Neoplasia 2013)
    653. HER2 and breast cancer stem cells: more than meets the eye. (PubMed id 23740771)1 Korkaya H. and Wicha M.S. (Cancer Res. 2013)
    654. Discrepancies between HER2 assessment from core needle biopsies and surgical specimens of invasive ductal breast carcinoma. (PubMed id 23468259)1 Wojnar A....DziA9giel P. (Adv Clin Exp Med 2013)
    655. Over-expression of Her-2 in colorectal cancer tissue, but not in serum, constitutes an independent worse prognostic factor. (PubMed id 23722824)1 Lim S.W....Shin M.G. (Cell Oncol (Dordr) 2013)
    656. Model-based analysis of HER activation in cells co-expressing EGFR, HER2 and HER3. (PubMed id 23990774)1 Shankaran H....Resat H. (PLoS Comput. Biol. 2013)
    657. Gamma-irradiation induces HER-2/neu overexpression in breast cancer cell lines and sensitivity to treatment with trastuzumab. (PubMed id 23311575)1 Voutsas I.F....Baxevanis C.N. (Int. J. Radiat. Biol. 2013)
    658. Atomic force microscopy study of the effect of HER 2 antibody on EGF mediated ErbB ligand-receptor interaction. (PubMed id 23219876)1 Zhang X....Fang X. (Nanomedicine 2013)
    659. Pak1 kinase links ErbB2 to I^-catenin in transformation of breast epithelial cells. (PubMed id 23576562)1 Arias-Romero L.E....Chernoff J. (Cancer Res. 2013)
    660. Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers. (PubMed id 23470965)1 Yu H.A....Riely G.J. (Clin. Cancer Res. 2013)
    661. EpCAM expression varies significantly and is differentially associated with prognosis in the luminal B HER2(+), basal-like, and HER2 intrinsic subtypes of breast cancer. (PubMed id 23519058)1 Soysal S.D....Gillanders W.E. (Br. J. Cancer 2013)
    662. Expression status of fatty acid synthase (FAS) but not HER2 is correlated with the differentiation grade and prognosis of esophageal carcinoma. (PubMed id 23419663)1 Wu D....Wei Q. (Hepatogastroenterology 2013)
    663. Is it necessary to evaluate nuclei in HER2 FISH evaluation? (PubMed id 23270898)1 LA^pez C....Lejeune M. (Am. J. Clin. Pathol. 2013)
    664. Clinicopathologic characteristics of HER2 FISH-ambiguous breast cancer at a single institution. (PubMed id 23108020)1 Clay M.R....Jensen K.C. (Am. J. Surg. Pathol. 2013)
    665. HER2 amplification and clinicopathological characteristics in a large Asian cohort of rare mucinous ovarian cancer. (PubMed id 23620766)1 Chay W.Y....Goh L.K. (PLoS ONE 2013)
    666. Lung cancer that harbors an HER2 mutation: epidemiologic characteristics and therapeutic perspectives. (PubMed id 23610105)1 MaziA"res J....Gautschi O. (J. Clin. Oncol. 2013)
    667. Validation of a new classifier for the automated analysis of the human epidermal growth factor receptor 2 (HER2) gene amplification in breast cancer specimens. (PubMed id 23379971)1 Furrer D....Diorio C. (Diagn Pathol 2013)
    668. Correlation analysis of c-myc, p21(WAF/CIP1), p53, C-erbB-2 and COX-2 proteins in esophageal squamous cell carcinoma. (PubMed id 23177619)1 Gomes T.S....Ribeiro D.A. (Pathol. Res. Pract. 2013)
    669. HER2/neu gene determination in women screened for breast carcinoma: how screening programs reduce the skyrocketing cost of targeted therapy. (PubMed id 24023299)1 Brunelli M....Bonetti F. (Anticancer Res. 2013)
    670. Oncogenic PIK3CA gene mutations and HER2/neu gene amplifications determine the sensitivity of uterine serous carcinoma cell lines to GDC-0980, a selective inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2). (PubMed id 23891627)1 English D.P....Santin A.D. (Am. J. Obstet. Gynecol. 2013)
    671. Amplification of Her-2/neu oncogene in GERD - Barrett's metaplasia a89 dysplasia - adenocarcinoma sequence. (PubMed id 23591735)1 Mokrowiecka A....Malecka-Panas E. (Hepatogastroenterology 2013)
    672. Towards sustained silencing of HER2/neu in cancer by epigenetic editing. (PubMed id 23814024)1 Falahi F....Rots M.G. (Mol. Cancer Res. 2013)
    673. Cranial magnetic resonance imaging in the staging of HER2-positive Breast Cancer Patients. (PubMed id 23548965)1 Kaplan M.A....Isikdogan A. (Onkologie 2013)
    674. Increased lymphocytic infiltration in breast cancer correlated with molecular subtypes and HER2 gene amplification. (PubMed id 23551496)1 Tsang J.Y....Tse G.M. (Histopathology 2013)
    675. New targetable oncogenes in non-small-cell lung cancer. (PubMed id 23401445)1 Oxnard G.R....JAonne P.A. (J. Clin. Oncol. 2013)
    676. Quantitation of sentinel node metastatic burden and Her-2/neu over-expression accurately predicts residual axillary nodal involvement and extranodal disease in breast cancer. (PubMed id 23523315)1 Chae A.W....Khatri V.P. (Eur J Surg Oncol 2013)
    677. Frequency of HER-2 positivity in rectal cancer and prognosis. (PubMed id 23282976)1 Conradi L.C....Liersch T. (Am. J. Surg. Pathol. 2013)
    678. Activating HER2 mutations in HER2 gene amplification negative breast cancer. (PubMed id 23220880)1 Bose R....Ellis M.J. (Cancer Discov 2013)
    679. Analysis of expression of membrane-bound tumor markers in ductal carcinoma in situ of the breast: paving the way for molecular imaging. (PubMed id 23744486)1 Vermeulen J.F....van Diest P.J. (Cell Oncol (Dordr) 2013)
    680. Mediator of ERBB2-driven cell motility (MEMO) promotes extranuclear estrogen receptor signaling involving the growth factor receptors IGF1R and ERBB2. (PubMed id 23861392)1 Jiang K....Ye Q. (J. Biol. Chem. 2013)
    681. 6 months versus 12 months of adjuvant trastuzumab for patients with HER2-positive early breast cancer (PHARE): a randomised phase 3 trial. (PubMed id 23764181)1 Pivot X....Kramar A. (Lancet Oncol. 2013)
    682. Clinical significance of nucleophosmin/B23 and human epidermal growth factor receptor 2/neu expressions in gastric cancers. (PubMed id 23489260)1 Zhou F....Yue L. (APMIS 2013)
    683. Prognostic significance of c-erbB2 overexpression in patients with metastatic gastric cancer. (PubMed id 22911549)1 Bayrak M....Manavoglu O. (amp 2013)
    684. Construction and characterization of novel, completely human serine protease therapeutics targeting Her2/neu. (PubMed id 23493312)1 Cao Y....Rosenblum M.G. (Mol. Cancer Ther. 2013)
    685. Leucine-rich repeat and immunoglobulin domain-containing protein-1 (Lrig1) negative regulatory action toward ErbB receptor tyrosine kinases is opposed by leucine-rich repeat and immunoglobulin domain-containing protein 3 (Lrig3). (PubMed id 23723069)1 Rafidi H....Sweeney C. (J. Biol. Chem. 2013)
    686. Expression of epidermal growth factors and a tight junction protein in the nasal mucosa of patients with chronic hypertrophic rhinitis. (PubMed id 23137868)1 Nguyen K.H....Shibata M. (Allergol Immunopathol (Madr) 2013)
    687. Directed evolution of Her2/neu-binding IgG1-Fc for improved stability and resistance to aggregation by using yeast surface display. (PubMed id 23267121)1 Traxlmayr M.W....Obinger C. (amp 2013)
    688. Effect of HER2 on prognosis and benefit from peri-operative chemotherapy in early oesophago-gastric adenocarcinoma in the MAGIC trial. (PubMed id 23233651)1 Okines A.F....Stenning S. (Ann. Oncol. 2013)
    689. Prognostic role of human epidermal growth factor receptor in gastric cancer: a systematic review and meta-analysis. (PubMed id 23871709)1 Chen C....Xu W.P. (Arch. Med. Res. 2013)
    690. STAT1 gene expression is enhanced by nuclear EGFR and HER2 via cooperation with STAT3. (PubMed id 22693070)1 Han W....Lo H.W. (Mol. Carcinog. 2013)
    691. Receptor protein-tyrosine phosphatase I+ regulates focal adhesion kinase phosphorylation and ErbB2 oncoprotein-mediated mammary epithelial cell motility. (PubMed id 24217252)1 Boivin B....Tonks N.K. (J. Biol. Chem. 2013)
    692. Early onset HER2-positive breast cancer is associated with germline TP53 mutations. (PubMed id 21761402)1 Melhem-Bertrandt A....Arun B.K. (Cancer 2012)
    693. Protein interactions with HER-family receptors can have different characteristics depending on the hosting cell line. (PubMed id 22200885)1 Barta P....Andersson K. (Int. J. Oncol. 2012)
    694. Simultaneous copy number gains of NUPR1 and ERBB2 predicting poor prognosis in early-stage breast cancer. (PubMed id 22938721)1 Jung S.H....Chung Y.J. (BMC Cancer 2012)
    695. Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a/125b and DNA methylation. (PubMed id 23146892)1 He J....Jiang B.H. (EMBO Rep. 2012)
    696. NRF2 inhibition represses ErbB2 signaling in ovarian carcinoma cells: implications for tumor growth retardation and docetaxel sensitivity. (PubMed id 22387177)1 Manandhar S....Kwak M.K. (amp 2012)
    697. Expression levels of HER2/neu and those of collocated genes at 17q12-21, in breast cancer. (PubMed id 22552811)1 Glynn R.W....Kerin M.J. (Oncol. Rep. 2012)
    698. Intratumoral heterogeneity of HER2 gene amplification in breast cancer: its clinicopathological significance. (PubMed id 22388760)1 Seol H....Park S.Y. (Mod. Pathol. 2012)
    699. Seventeen-gene signature from enriched Her2/Neu mammary tumor-initiating cells predicts clinical outcome for human HER2+:ERI+- breast cancer. (PubMed id 22460789)1 Liu J.C....Zacksenhaus E. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    700. A role of Rab7 in stabilizing EGFR-Her2 and in sustaining Akt survival signal. (PubMed id 21928319)1 Wang T....Hong W. (J. Cell. Physiol. 2012)
    701. Polymorphism rs4919510:C&gt;G in mature sequence of human microRNA-608 contributes to the risk of HER2-positive breast cancer but not other subtypes. (PubMed id 22586447)1 Huang A.J....Shao Z.M. (PLoS ONE 2012)
    702. HER2/neu expression in head and neck squamous cell carcinoma patients is not significantly elevated. (PubMed id 22938479)1 Sardari Y....Hamzavi M. (Asian Pac. J. Cancer Prev. 2012)
    703. Human epidermal growth factor receptor-2 gene amplification in gastric cancer using tissue microarray technology. (PubMed id 22253521)1 Tsapralis D....Karamitopoulou E. (World J. Gastroenterol. 2012)
    704. Leptin and HER-2 are associated with gastric cancer progression and prognosis of patients. (PubMed id 22883999)1 Geng Y....Yin Y. (amp 2012)
    705. Potential role of HER2-overexpressing exosomes in countering trastuzumab-based therapy. (PubMed id 21465472)1 Ciravolo V....Pupa S.M. (J. Cell. Physiol. 2012)
    706. Prognostic significance of CD44 and c-erb-B2 protein overexpression in patients with gastric cancer. (PubMed id 23435135)1 Doventas A....Doventas Y. (Hepatogastroenterology 2012)
    707. Cross-talk between HER2 and MED1 regulates tamoxifen resistance of human breast cancer cells. (PubMed id 22964581)1 Cui J....Zhang X. (Cancer Res. 2012)
    708. Trastuzumab combined with docetaxel-based regimens in previously treated metastatic gastric cancer patients with HER2 over-expression. (PubMed id 22534547)1 Dai G.H....Zhong M. (Hepatogastroenterology 2012)
    709. Prognosis significance of HER-2/neu overexpression/amplification in Chinese patients with curatively resected gastric cancer after the ToGA clinical trial. (PubMed id 23249720)1 Zhou F....Wang L. (World J Surg Oncol 2012)
    710. Cap-dependent mRNA translation and the ubiquitin-proteasome system cooperate to promote ERBB2-dependent esophageal cancer phenotype. (PubMed id 22767218)1 Issaenko O.A....Dahlberg P.S. (Cancer Gene Ther. 2012)
    711. HER2 status determination using RNA-ISH--a rapid and simple technique showing high correlation with FISH and IHC in 141 cases of breast cancer. (PubMed id 22763874)1 Alba J....GarcA-a-Caballero T. (Histol. Histopathol. 2012)
    712. HER-2/neu overexpression is an independent prognostic factor for intestinal-type and early-stage gastric cancer patients. (PubMed id 22064554)1 Liu W....Yu Y. (J. Clin. Gastroenterol. 2012)
    713. Factors influencing the hormone receptor and HER2 levels in breast cancer: a population-based analysis. (PubMed id 22414972)1 Tas F. (Onkologie 2012)
    714. HER-2/neu-mediated down-regulation of biglycan associated with altered growth properties. (PubMed id 22582394)1 Recktenwald C.V....Seliger B. (J. Biol. Chem. 2012)
    715. Relationships between progesterone receptor isoforms and the HER/ErbB receptors and ligands network in 299 primary breast cancers. (PubMed id 22505232)1 Lindet C....Bonneterre J. (Int. J. Biol. Markers 2012)
    716. HER2 expression in gastric and gastroesophageal junction adenocarcinoma in a US population: clinicopathologic analysis with proposed approach to HER2 assessment. (PubMed id 21617522)1 Kunz P.L....Pai R.K. (amp 2012)
    717. Association of HER-2 copy number and HER-2/CEP-17 ratio with neoadjuvant taxane-containing chemotherapy sensitivity in locally advanced breast cancer. (PubMed id 22561335)1 Yu K.D....Shao Z.M. (Oncologist 2012)
    718. Gene expression profiles of phaeochromocytomas with ERBB2 overexpression reveal a new molecular mechanism tumourigenicity. (PubMed id 22429000)1 Qi Y....Ning G. (Clin. Endocrinol. (Oxf) 2012)
    719. A phase Ib study of preoperative lapatinib, paclitaxel, and gemcitabine combination therapy in women with HER2 positive early breast cancer. (PubMed id 22006161)1 Park I.H....Ro J. (Invest New Drugs 2012)
    720. A retrospective study investigating the rate of HER2 discordance between primary breast carcinoma and locoregional or metastatic disease. (PubMed id 23176370)1 Chan A....Ingram D. (BMC Cancer 2012)
    721. Triple-negative phenotype is of adverse prognostic value in patients treated with dose-dense sequential adjuvant chemotherapy: a translational research analysis in the context of a Hellenic Cooperative Oncology Group (HeCOG) randomized phase III trial. (PubMed id 21901395)1 Skarlos P....Fountzilas G. (Cancer Chemother. Pharmacol. 2012)
    722. Lapatinib plus capecitabine for brain metastases in patients with human epidermal growth factor receptor 2-positive advanced breast cancer: a review of the Anatolian Society of Medical Oncology (ASMO) experience. (PubMed id 23207619)1 Cetin B....Buyukberber S. (Onkologie 2012)
    723. Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment. (PubMed id 23307622)1 CufA- S....Menendez J.A. (Oncotarget 2012)
    724. Expression of EGFR, Her2 predict lymph node metastasis (LNM)-associated metastasis in colorectal cancer. (PubMed id 23220854)1 Lu Y....Cai S. (Cancer Biomark 2012)
    725. HER2-negative (1+) breast cancer with unfavorable prognostic features: to FISH or not to FISH? (PubMed id 22412042)1 Iorfida M....Colleoni M. (Ann. Oncol. 2012)
    726. Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasis. (PubMed id 22952421)1 Deng X....Yang X.H. (Neoplasia 2012)
    727. Analysis of HER2 gene amplification and protein expression in esophageal squamous cell carcinoma. (PubMed id 21318736)1 Zhan N....Xiong C.L. (Med. Oncol. 2012)
    728. [The search for protein overexpression and HER2 gene amplification in gastric cancer by immunohistochemistry and in situ hybridization: experience of the CHU Hassan II of Fez]. (PubMed id 23397021)1 El Fatemi H....Mesbahi O. (Pan Afr Med J 2012)
    729. The EGF receptor and HER2 participate in TNF-I+-dependent MAPK activation and IL-8 secretion in intestinal epithelial cells. (PubMed id 22988345)1 Jijon H.B....Beck P.L. (Mediators Inflamm. 2012)
    730. Coexpression of p53 and Ki 67 and lack of c-erbB2 expression in oral leukoplakias in India. (PubMed id 22641442)1 Kumar P....Rathod G.P. (Braz Oral Res 2012)
    731. Frequency of driver mutations in lung adenocarcinoma from female never-smokers varies with histologic subtypes and age at diagnosis. (PubMed id 22317764)1 Zhang Y....Chen H. (Clin. Cancer Res. 2012)
    732. Trastuzumab-DM1: a clinical update of the novel antibody-drug conjugate for HER2-overexpressing breast cancer. (PubMed id 23196784)7 Barginear M.F....Budman D.R. (Mol. Med. 2012)
    733. Expression screening of 17q12-21 amplicon reveals GRB7 as an ERBB2-dependent oncogene. (PubMed id 22584052)1 Saito M....Watanabe S. (FEBS Lett. 2012)
    734. A population-based study of Kurdish breast cancer in northern Iraq: hormone receptor and HER2 status. A comparison with Arabic women and United States SEER data. (PubMed id 22727195)1 Runnak M.A....Michael H.D. (BMC Womens Health 2012)
    735. Expression of activated type I receptor tyrosine kinases in early breast cancer. (PubMed id 22562124)1 Spears M....Bartlett J.M. (Breast Cancer Res. Treat. 2012)
    736. ErbB2, EphrinB1, Src kinase and PTPN13 signaling complex regulates MAP kinase signaling in human cancers. (PubMed id 22279592)1 Vermeer P.D....Lee J.H. (PLoS ONE 2012)
    737. Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity. (PubMed id 22315411)1 Tsutsumi S....Neckers L.M. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    738. HER2 status in unusual histological variants of gastric adenocarcinomas. (PubMed id 22067088)1 GiuffrA" G....Tuccari G. (J. Clin. Pathol. 2012)
    739. Sorafenib in combination with capecitabine: an oral regimen for patients with HER2-negative locally advanced or metastatic breast cancer. (PubMed id 22412143)1 Baselga J....Costa F. (J. Clin. Oncol. 2012)
    740. Expression of HER2 and bradykinin Ba88 receptors in precursor lesions of gallbladder carcinoma. (PubMed id 22468084)1 Toledo C....Poblete M.T. (World J. Gastroenterol. 2012)
    741. HER-2/neu gene amplification in carcinoma ex pleomorphic adenoma in relation to progression and prognosis: a chromogenic in-situ hybridization study. (PubMed id 22486195)1 Hashimoto K....Oda Y. (Histopathology 2012)
    742. Genetic heterogeneity of HER2 in breast cancer: impact on HER2 testing and its clinicopathologic significance. (PubMed id 22476857)1 Yang Y.L....Fu L. (Breast Cancer Res. Treat. 2012)
    743. Activated HER-receptors in predicting outcome of ER-positive breast cancer patients treated with adjuvant endocrine therapy. (PubMed id 22854050)1 Larsen M.S....Rasmussen B.B. (Breast 2012)
    744. Chromogenic in situ hybridization (CISH) to detect HER2 gene amplification in breast and gastric cancer: comparison with immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). (PubMed id 23121603)1 Kiyose S....Sugimura H. (Pathol. Int. 2012)
    745. Profiling signalling pathways in formalin-fixed and paraffin-embedded breast cancer tissues reveals cross-talk between EGFR, HER2, HER3 and uPAR. (PubMed id 21391216)1 Berg D....Becker K.F. (J. Cell. Physiol. 2012)
    746. Correlation of HER2, p95HER2 and HER3 expression and treatment outcome of lapatinib plus capecitabine in her2-positive metastatic breast cancer. (PubMed id 22848366)1 Han S.W....Kim T.Y. (PLoS ONE 2012)
    747. Expression profiling during mammary epithelial cell three-dimensional morphogenesis identifies PTPRO as a novel regulator of morphogenesis and ErbB2-mediated transformation. (PubMed id 22851698)1 Yu M....Muthuswamy S.K. (Mol. Cell. Biol. 2012)
    748. Down regulation of CD24 and HER-2/neu in breast carcinoma cells by activated human dendritic cell. Role of STAT3. (PubMed id 22480875)1 Hira S.K. and Manna P.P. (Cell. Immunol. 2012)
    749. MicroRNA-125b down-regulation mediates endometrial cancer invasion by targeting ERBB2. (PubMed id 22460089)1 Shang C....Meng L.R. (Med. Sci. Monit. 2012)
    750. Multiorgan metastasis of human HER-2+ breast cancer in Rag2-/-;Il2rg-/- mice and treatment with PI3K inhibitor. (PubMed id 22737248)1 Nanni P....Lollini P.L. (PLoS ONE 2012)
    751. PGC-1I+ promotes the growth of ErbB2/Neu-induced mammary tumors by regulating nutrient supply. (PubMed id 22266114)1 Klimcakova E....St-Pierre J. (Cancer Res. 2012)
    752. Recycling of EGFR and ErbB2 is associated with impaired Hrs tyrosine phosphorylation and decreased deubiquitination by AMSH. (PubMed id 22800866)1 Meijer I.M....van Leeuwen J.E. (Cell. Signal. 2012)
    753. Intrinsic and acquired resistance to HER2-targeted therapies in HER2 gene-amplified breast cancer: mechanisms and clinical implications. (PubMed id 22471661)1 Rexer B.N. and Arteaga C.L. (Crit Rev Oncog 2012)
    754. Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2. (PubMed id 22451678)1 Wang Y.N....Hung M.C. (J. Biol. Chem. 2012)
    755. Negative/low HER2 expression alone or combined with E-cadherin positivity is predictive of better prognosis in patients with breast carcinoma. (PubMed id 22237715)1 Karray-Chouayekh S....Mokdad-Gargouri R. (Histol. Histopathol. 2012)
    756. Comprehensive analysis of HER2 expression and gene amplification in gastric cancers using immunohistochemistry and in situ hybridization: which scoring system should we use? (PubMed id 21855114)1 Park Y.S....Kang Y.K. (Hum. Pathol. 2012)
    757. Functional isolation of activated and unilaterally phosphorylated heterodimers of ERBB2 and ERBB3 as scaffolds in ligand-dependent signaling. (PubMed id 22733765)1 Zhang Q....Landgraf R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    758. In situ detection of HER2:HER2 and HER2:HER3 protein-protein interactions demonstrates prognostic significance in early breast cancer. (PubMed id 21638049)1 Spears M....Bartlett J.M. (Breast Cancer Res. Treat. 2012)
    759. Serum enterolactone and postmenopausal breast cancer risk by estrogen, progesterone and herceptin 2 receptor status. (PubMed id 21544804)1 Zaineddin A.K....Chang-Claude J. (Int. J. Cancer 2012)
    760. Predictive value of HER2 serum levels in patients treated with lapatinib or trastuzumab -- a translational project in the neoadjuvant GeparQuinto trial. (PubMed id 22892393)1 Witzel I....MA1ller V. (Br. J. Cancer 2012)
    761. HER2/neu gene amplification and protein overexpression in gastric and gastroesophageal junction adenocarcinoma: a review of histopathology, diagnostic testing, and clinical implications. (PubMed id 22646280)1 Hechtman J.F. and Polydorides A.D. (amp 2012)
    762. Impact of expression of human epidermal growth factor receptors EGFR and ERBB2 on survival in stage II/III gastric cancer. (PubMed id 22977193)1 Terashima M....Sasako M. (Clin. Cancer Res. 2012)
    763. An immunohistochemical study of HER2 expression in meningioma and its correlation with tumor grade. (PubMed id 22420924)1 Mahzouni P. and Movahedipour M. (Pathol. Res. Pract. 2012)
    764. The signaling and transformation potency of the overexpressed HER2 protein is dependent on the normally-expressed EGFR. (PubMed id 21911055)1 Zhou X. and Agazie Y.M. (Cell. Signal. 2012)
    765. Phosphorylation of signal transducer and activator of transcription 3 (STAT3) correlates with Her-2 status, carbonic anhydrase 9 expression and prognosis in esophageal cancer. (PubMed id 22484976)1 Schoppmann S.F....Birner P. (amp 2012)
    766. Comparing of IRS and Her2 as immunohistochemical scoring schemes in gastroenteropancreatic neuroendocrine tumors. (PubMed id 22558472)1 Kaemmerer D....Hommann M. (Int J Clin Exp Pathol 2012)
    767. L1CAM binds ErbB receptors through Ig-like domains coupling cell adhesion and neuregulin signalling. (PubMed id 22815787)1 Donier E....Cabedo H. (PLoS ONE 2012)
    768. HER-2/neu gene amplification assessment in breast cancer patients in Isfahan province by real time PCR, differential PCR and immunohistochemistry. (PubMed id 22326523)1 Hojati Z. and Orangi E. (Gene 2012)
    769. Expression and association of HER2 with prognosis in early-stage (T1-T2N0M0) non-small cell lung cancer. (PubMed id 22736332)1 Xia Q....Jang W. (Tumour Biol. 2012)
    770. Discovery of novel 5-alkynyl-4-anilinopyrimidines as potent, orally active dual inhibitors of EGFR and Her-2 tyrosine kinases. (PubMed id 22101132)1 Suzuki N....Wada T. (amp 2012)
    771. Heterogeneity of ERBB2 amplification in adenocarcinoma, squamous cell carcinoma and large cell undifferentiated carcinoma of the lung. (PubMed id 22899293)1 Grob T.J....Wilczak W. (Mod. Pathol. 2012)
    772. Fluorescence in situ hybridization mapping of esophagectomy specimens from patients with Barrett's esophagus with high-grade dysplasia or adenocarcinoma. (PubMed id 21820152)1 Brankley S.M....Halling K.C. (Hum. Pathol. 2012)
    773. Moderate immunohistochemical expression of HER-2 (2+) without HER-2 gene amplification is a negative prognostic factor in early breast cancer. (PubMed id 22951668)1 Rossi V....Montemurro F. (Oncologist 2012)
    774. Lung adenocarcinomas with HER2-activating mutations are associated with distinct clinical features and HER2/EGFR copy number gains. (PubMed id 22071781)1 Li C....Chen H. (J Thorac Oncol 2012)
    775. Change in HER2 status during breast tumor progression. (PubMed id 23735945)1 Niikura N. and Ueno N.T. (Cancer Biomark 2012-2013)
    776. Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial. (PubMed id 22153890)1 Gianni L....Valagussa P. (Lancet Oncol. 2012)
    777. Her-2/neu assessment for gastric carcinoma: validation of scoring system. (PubMed id 22260838)1 Mrklic I....Tomic S. (Hepatogastroenterology 2012)
    778. The relationship between the stromal mast cell number, microvessel density, c-erbB-2 staining and survival and prognostic factors in colorectal carcinoma. (PubMed id 22627628)1 ElezoA9lu B. and Tolunay S. (Turk Patoloji Derg 2012)
    779. MEK inhibition leads to PI3K/AKT activation by relieving a negative feedback on ERBB receptors. (PubMed id 22552284)1 Turke A.B....Engelman J.A. (Cancer Res. 2012)
    780. Early HER2 dysregulation in gastric and oesophageal carcinogenesis. (PubMed id 22882541)1 Fassan M....Rugge M. (Histopathology 2012)
    781. Modeling invasive breast cancer: growth factors propel progression of HER2-positive premalignant lesions. (PubMed id 22139081)1 Pradeep C.R....Yarden Y. (Oncogene 2012)
    782. Clinical implications of pathophysiological and demographic covariates on the population pharmacokinetics of trastuzumab emtansine, a HER2-targeted antibody-drug conjugate, in patients with HER2-positive metastatic breast cancer. (PubMed id 21953571)1 Gupta M....Girish S. (J Clin Pharmacol 2012)
    783. ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression. (PubMed id 22464443)1 Rafn B....Kallunki T. (Mol. Cell 2012)
    784. Cross-regulation between FOXA1 and ErbB2 signaling in estrogen receptor-negative breast cancer. (PubMed id 22577344)1 Naderi A....Dowhan D.H. (Neoplasia 2012)
    785. Decreased expression of C-erbB-2 and CXCR4 in breast cancer after primary chemotherapy. (PubMed id 23046610)1 Yang S.X....Jiang J. (J Transl Med 2012)
    786. Characterization of EGFR and ErbB2 expression in atopic dermatitis patients. (PubMed id 22552355)1 SAoAof A....Bradley M. (Arch. Dermatol. Res. 2012)
    787. Coordinated expression of oestrogen and androgen receptors in HER2-positive breast carcinomas: impact on proliferative activity. (PubMed id 22039288)1 Lin F.d.e. .M....Carvalho F.M. (J. Clin. Pathol. 2012)
    788. Clinicopathological characteristics of human epidermal growth factor receptor 2-positive Barrett's adenocarcinoma. (PubMed id 23180947)1 Tanaka T....Yoshino T. (World J. Gastroenterol. 2012)
    789. Prognostic role and HER2 expression of circulating tumor cells in peripheral blood of patients prior to radical cystectomy: a prospective study. (PubMed id 22277196)1 Rink M....Riethdorf S. (Eur. Urol. 2012)
    790. Association of HER2/ErbB2 expression and gene amplification with pathologic features and prognosis in esophageal adenocarcinomas. (PubMed id 22252257)1 Yoon H.H....Sinicrope F.A. (Clin. Cancer Res. 2012)
    791. The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways. (PubMed id 22393391)1 Jonckheere N....Van Seuningen I. (PLoS ONE 2012)
    792. ERBB2 overexpression triggers transient high mechanoactivity of breast tumor cells. (PubMed id 22407943)1 Martin M....KAos J.A. (Cytoskeleton (Hoboken) 2012)
    793. Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu. (PubMed id 22325357)1 De GrA"ve J....Schallier D. (Lung Cancer 2012)
    794. PIK3CA mutations, PTEN, and pHER2 expression and impact on outcome in HER2-positive early-stage breast cancer patients treated with adjuvant chemotherapy and trastuzumab. (PubMed id 22172323)1 Jensen J.D....Ewertz M. (Ann. Oncol. 2012)
    795. Observing the temperature dependent transition of the GP2 peptide using terahertz spectroscopy. (PubMed id 23209703)1 Sun Y....Pickwell-Macpherson E. (PLoS ONE 2012)
    796. Regulatory T cells increase in breast cancer and in stage IV breast cancer. (PubMed id 22116346)1 Wang Z.K....Jiao S.C. (Cancer Immunol. Immunother. 2012)
    797. Immunohistochemical correlation of epidermal growth factor receptor and c-erbB-2 with histopathologic grading of mucoepidermoid carcinoma. (PubMed id 23361279)1 Khiavi M.M....Halimi M. (J Cancer Res Ther 2012)
    798. The interplay of HER2/HER3/PI3K and EGFR/HER2/PLC-I^1 signalling in breast cancer cell migration and dissemination. (PubMed id 22262199)1 Balz L.M....Dittmar T. (J. Pathol. 2012)
    799. Increased concentrations of growth factors and activation of the EGFR system in breast cancer. (PubMed id 23089711)1 Olsen D.A....Brandslund I. (Clin. Chem. Lab. Med. 2012)
    800. The Na+/H+ exchanger NHE1, but not the Na+, HCO3(-) cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2. (PubMed id 22120673)1 Lauritzen G....Pedersen S.F. (Cancer Lett. 2012)
    801. HER-2 expression in immunohistochemistry has no prognostic significance in gastric cancer patients. (PubMed id 22645475)1 Halon A....Matkowski R. (ScientificWorldJournal 2012)
    802. Human epidermal growth factor receptor-2 in oesophageal cancers: an observational study. (PubMed id 23197890)1 Al-Momani H....Edwards P. (World J. Gastroenterol. 2012)
    803. Efficacy of primed in situ labelling in determination of HER-2 gene amplification and CEN-17 status in breast cancer tissue. (PubMed id 22502695)1 Salimi M....Majidzadeh-A K. (Asian Pac. J. Cancer Prev. 2012)
    804. Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas. (PubMed id 22761469)1 Arcila M.E....Ladanyi M. (Clin. Cancer Res. 2012)
    805. Tumor necrosis factor I+ stimulates Her-2 cleavage by activated caspase-8. (PubMed id 22922291)1 Li X....Ren H. (Cell. Physiol. Biochem. 2012)
    806. A case of complete hydatidiform mole in a perimenopausal woman with diagnostic usefulness of p57(kip2) immunohistochemistry and HER2 fluorescent in situ hybridization. (PubMed id 22197173)1 Hatanaka K....Tanimoto A. (Pathol. Res. Pract. 2012)
    807. HER2 evaluation and its impact on breast cancer treatment decisions. (PubMed id 21540562)1 Goddard K.A....Wax C. (Public Health Genomics 2012)
    808. HER2-associated radioresistance of breast cancer stem cells isolated from HER2-negative breast cancer cells. (PubMed id 23091114)1 Duru N....Li J.J. (Clin. Cancer Res. 2012)
    809. HER2/HER3 signaling regulates NK cell-mediated cytotoxicity via MHC class I chain-related molecule A and B expression in human breast cancer cell lines. (PubMed id 22301547)1 Okita R....Kiessling R. (J. Immunol. 2012)
    810. Brain metastases in Asian HER2-positive breast cancer patients: anti-HER2 treatments and their impact on survival. (PubMed id 22918394)1 Yap Y.S....Ro J. (Br. J. Cancer 2012)
    811. Her2/neu small interfering RNA delivered in culture by a streptavidin nanoparticle. (PubMed id 22520071)1 Liu X....Hnatowich D.J. (Curr Drug Deliv 2012)
    812. A-62176, a potent topoisomerase inhibitor, inhibits the expression of human epidermal growth factor receptor 2. (PubMed id 22732416)1 Kim H.L....Kwon Y. (Cancer Lett. 2012)
    813. Lack of independent prognostic and predictive value of centromere 17 copy number changes in breast cancer patients with known HER2 and TOP2A status. (PubMed id 22153616)1 Nielsen K.V....Mouridsen H.T. (Mol Oncol 2012)
    814. Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling. (PubMed id 21743488)1 Pradeep C.R....Yarden Y. (Oncogene 2012)
    815. Organotropism and prognostic marker discordance in distant metastases of breast carcinoma: fact or fiction? A clinicopathologic analysis. (PubMed id 21840040)1 St Romain P....Fan F. (Hum. Pathol. 2012)
    816. Primary human ovarian epithelial cancer cells broadly express HER2 at immunologically-detectable levels. (PubMed id 23189165)1 Lanitis E....Powell D.J. (PLoS ONE 2012)
    817. Model-based global sensitivity analysis as applied to identification of anti-cancer drug targets and biomarkers of drug resistance in the ErbB2/3 network. (PubMed id 22085636)1 Lebedeva G....Goryanin I. (Eur J Pharm Sci 2012)
    818. Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells. (PubMed id 22676470)1 Ren X.R....Chen W. (Breast Cancer Res. 2012)
    819. Involvement of CXCR4 chemokine receptor in metastastic HER2-positive esophageal cancer. (PubMed id 23082154)1 Gros S.J....Izbicki J.R. (PLoS ONE 2012)
    820. The atypical histone macroH2A1.2 interacts with HER-2 protein in cancer cells. (PubMed id 22589551)1 Li X....Kuwada S.K. (J. Biol. Chem. 2012)
    821. A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion. (PubMed id 21986939)1 Rao V.H....Hansen L.A. (Oncogene 2012)
    822. MUC5AC, cytokeratin 20 and HER2 expression and K-RAS mutations within mucinogenic growth in congenital pulmonary airway malformations. (PubMed id 22348416)1 Rossi G....Rivasi F. (Histopathology 2012)
    823. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    824. Her-2/neu and topoisomerase III+ in advanced breast cancer: a comprehensive FISH analysis of 245 cases. (PubMed id 22555090)1 Engelstaedter V....Mayr D. (Diagn. Mol. Pathol. 2012)
    825. C-Erb-b2 oncogene expression in intraductal proliferative lesions of the breast. (PubMed id 22364303)1 Eren F....Aydin O. (Bosn J Basic Med Sci 2012)
    826. Serum levels of epidermal growth factor, transforming growth factor, and c-erbB2 in ovarian cancer. (PubMed id 22914212)1 Balcan E....Cift T. (Int. J. Gynecol. Cancer 2012)
    827. Increased number of regulatory T cells (T-regs) in the peripheral blood of patients with Her-2/neu-positive early breast cancer. (PubMed id 22760213)1 Decker T....GAPtze K. (J. Cancer Res. Clin. Oncol. 2012)
    828. [Immunohistochemical study of adhesive molecules Her-2/neu in nonendometrial carcinoma of corpus uteri]. (PubMed id 22712297)1 abdulaeva G.M....Gadzhieva S.M. (Arkh. Patol. 2012)
    829. Transcriptional regulation of the protocadherin I^ cluster during Her-2 protein-induced mammary tumorigenesis results from altered N-glycan branching. (PubMed id 22665489)1 Guo H....Pierce M. (J. Biol. Chem. 2012)
    830. Successful treatment of HER-2-positive metastatic apocrine carcinoma of the skin with lapatinib and capecitabine. (PubMed id 22504780)1 Hidaka T....Aiba S. (Acta Derm. Venereol. 2012)
    831. Assessment of human epidermal growth factor receptor 2 status in urothelial carcinoma of the upper urinary tract: a study using dual-color in situ hybridization and immunohistochemistry. (PubMed id 22495372)1 Vershasselt-Crinquette M....Leroy X. (amp 2012)
    832. [Different Her-2 status in infiltrative and intraductal components of the breast cancer]. (PubMed id 22880416)1 PovilaA-tite P.E....Petrov A.V. (Arkh. Patol. 2012)
    833. Association between growth factor heregulin1I+ and receptors in growth of ovarian cancer cell line with high potentiality of peritoneal dissemination. (PubMed id 22790889)1 Nishiyama H....Fujimori K. (Fukushima J Med Sci 2012)
    834. Expression of Wnt3 activates Wnt/I^-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells. (PubMed id 23071104)1 Wu Y....Vadgama J.V. (Mol. Cancer Res. 2012)
    835. HER2 induces expression of leptin in human breast epithelial cells. (PubMed id 23261058)1 Cha Y....Moon A. (BMB Rep 2012)
    836. Gene expression profiling identifies sST2 as an effector of ErbB2-driven breast carcinoma cell motility, associated with metastasis. (PubMed id 22105364)1 Gillibert-Duplantier J....Badache A. (Oncogene 2012)
    837. HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation. (PubMed id 22956644)1 Takezawa K....Pao W. (Cancer Discov 2012)
    838. HER2 and TOP2A in high-risk early breast cancer patients treated with adjuvant epirubicin-based dose-dense sequential chemotherapy. (PubMed id 22240029)1 Fountzilas G....Arapantoni P. (J Transl Med 2012)
    839. Therapeutic strategies and mechanisms of tumorigenesis of HER2-overexpressing breast cancer. (PubMed id 20951604)1 Emde A....Yarden Y. (Crit. Rev. Oncol. Hematol. 2012)
    840. EGFR overexpression relates to triple negative profile and poor prognosis in breast cancer patients in Tunisia. (PubMed id 22394363)1 Kallel I....RebaA^ A. (J. Recept. Signal Transduct. Res. 2012)
    841. Lymph node ratio: a new feature for defining risk category of node-positive breast cancer patients. (PubMed id 22736300)1 Yang C....Fu L. (Int. J. Surg. Pathol. 2012)
    842. Receptor tyrosine kinase ErbB2 translocates into mitochondria and regulates cellular metabolism. (PubMed id 23232401)1 Ding Y....Tan M. (Nat Commun 2012)
    843. Human epidermal growth factor receptor 2 overexpression in breast cancer of patients with anti-Yo--associated paraneoplastic cerebellar degeneration. (PubMed id 22351748)1 Rojas-Marcos I....Graus F. (Neuro-oncology 2012)
    844. Quantification of HER expression and dimerization in patients' tumor samples using time-resolved FAPrster resonance energy transfer. (PubMed id 22829865)1 Ho-Pun-Cheung A....Lopez-Crapez E. (PLoS ONE 2012)
    845. MMP-9 increases HER2/neu expression and alters apoptosis levels in human mammary epithelial cells (HMEC). (PubMed id 22878890)1 Fatunmbi M....Aronica S.M. (Breast Cancer Res. Treat. 2012)
    846. ErbB-2 signals through Plexin-B1 to promote breast cancer metastasis. (PubMed id 22378040)1 Worzfeld T....Offermanns S. (J. Clin. Invest. 2012)
    847. Direct and immune mediated antibody targeting of ERBB receptors in a colorectal cancer cell-line panel. (PubMed id 23213241)1 Ashraf S.Q....Bodmer W.F. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    848. The hormone receptor, human epidermal growth factor receptor 2, and molecular subtype status of individual tumor foci in multifocal/multicentric invasive ductal carcinoma of breast. (PubMed id 21733550)1 Choi Y....Park S.Y. (Hum. Pathol. 2012)
    849. MET activation mediates resistance to lapatinib inhibition of HER2-amplified gastric cancer cells. (PubMed id 22238368)1 Chen C.T....Weiser M.R. (Mol. Cancer Ther. 2012)
    850. Comparison of two nomograms to predict pathologic complete responses to neoadjuvant chemotherapy for breast cancer: evidence that HER2-positive tumors need specific predictors. (PubMed id 22160638)1 Frati A....Rouzier R. (Breast Cancer Res. Treat. 2012)
    851. HER2/neu testing for anti-HER2-based therapies in patients with unresectable and/or metastatic gastric cancer. (PubMed id 22569536)1 GA^mez-Martin C....LA^pez-RA-os F. (J. Clin. Pathol. 2012)
    852. Gene expression pattern of the epidermal growth factor receptor family and LRIG1 in renal cell carcinoma. (PubMed id 22554477)1 Thomasson M....Henriksson R. (BMC Res Notes 2012)
    853. HER3 intracellular domains play a crucial role in HER3/HER2 dimerization and activation of downstream signaling pathways. (PubMed id 22983903)1 Choi B.K....An Z. (amp 2012)
    854. [Biological behaviour of colon cancer cells transfected with C-erbB2 shRNA plasmid]. (PubMed id 22482406)1 Zhao D.L....Sui Y.X. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2012)
    855. HER2/neu gene amplification heterogeneity: the significance of cells with a 3:1 HER2/CEP17 ratio. (PubMed id 22495367)1 Layfield L.J. and Schmidt R.L. (amp 2012)
    856. Human epidermal growth factor receptor 2 status and interval breast cancer in a population-based cancer registry study. (PubMed id 22585698)1 Musolino A....Ardizzoni A. (J. Clin. Oncol. 2012)
    857. Establishment and characterization of a novel ovarian serous adenocarcinoma cell line, TU-OS-4, that overexpresses EGFR and HER2. (PubMed id 23274876)1 Itamochi H....Harada T. (Hum. Cell 2012)
    858. Hormone status and demographics in early onset breast cancer patients. (PubMed id 22748546)1 Friend K.E....Feliberti E.C. (Am Surg 2012)
    859. Is obesity always a risk factor for all breast cancer patients? c-erbB2 expression is significantly lower in obese patients with early stage breast cancer. (PubMed id 22855166)1 Mousa U....Utkan G. (amp 2012)
    860. HER2 blockade in metastatic collecting duct carcinoma (CDC) of the kidney: a case report. (PubMed id 23207624)1 Bronchud M.H....Andreu X. (Onkologie 2012)
    861. Role of C-erbB2 expression in gallbladder cancer. (PubMed id 22499306)1 Kumari N....Baitha D.K. (amp 2012)
    862. A gene-protein assay for human epidermal growth factor receptor 2 (HER2): brightfield tricolor visualization of HER2 protein, the HER2 gene, and chromosome 17 centromere (CEN17) in formalin-fixed, paraffin-embedded breast cancer tissue sections. (PubMed id 22647525)1 Nitta H....Grogan T.M. (Diagn Pathol 2012)
    863. Epithelial-mesenchymal transition and stem cell markers in patients with HER2-positive metastatic breast cancer. (PubMed id 22973057)1 Giordano A....Reuben J.M. (Mol. Cancer Ther. 2012)
    864. A single ligand is sufficient to activate EGFR dimers. (PubMed id 22699492)1 Liu P....Leahy D.J. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    865. [HER-2/neu-testing in breast cancer: is the immunocytochemistry competent?]. (PubMed id 22880415)1 Matsionis A.A.8....PovilaA-tite P.E. (Arkh. Patol. 2012)
    866. Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin-induced activation of ErbB3. (PubMed id 22248472)1 McDonagh C.F....Nielsen U.B. (Mol. Cancer Ther. 2012)
    867. Comparison of four immunohistochemical tests and FISH for measuring HER2 expression in gastric carcinomas. (PubMed id 22437741)1 Cho E.Y....Kim S. (Pathology 2012)
    868. The expression of PCNA, c-erbB-2, p53, ER and PR as well as atypical hyperplasia in tissues nearby the breast cancer. (PubMed id 22057681)1 Jia Z....Sheng W. (J. Mol. Histol. 2012)
    869. Novel anti-HER2 monoclonal antibodies: synergy and antagonism with tumor necrosis factor-I+. (PubMed id 23033967)1 Ceran C....Yagci T. (BMC Cancer 2012)
    870. HER2 expression in breast cancer with nonamplified HER2 and gains of chromosome 17 centromere. (PubMed id 22417858)1 Panvichian R....Leelaudomlipi S. (amp 2012)
    871. ErbB2/Her-2 regulates the expression of Akt2 in prostate cancer cells. (PubMed id 21932427)1 Le Page C....Mes-Masson A.M. (Prostate 2012)
    872. Expression of epidermal growth factors, erbBs, in the nasal mucosa of patients with chronic hypertrophic rhinitis. (PubMed id 22327010)1 Nguyen K.H....Shibata M. ( journal for oto-rhino-laryngology and its related specialties 2012)
    873. HER2/neu and Ki-67 expression predict non-invasive recurrence following breast-conserving therapy for ductal carcinoma in situ. (PubMed id 22361634)1 Rakovitch E....Paszat L. (Br. J. Cancer 2012)
    874. [Expression and significance of HER-2/neu mRNA and RECK mRNA in breast carcinoma tissue]. (PubMed id 23189844)1 Shen B....Feng J.F. (Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2012)
    875. Quantitation of HER2/neu expression in primary gastroesophageal adenocarcinomas using conventional light microscopy and quantitative image analysis. (PubMed id 22646266)1 Jeung J....Liu C. (amp 2012)
    876. Phase II trial of preoperative paclitaxel, gemcitabine, and trastuzumab combination therapy in HER2 positive stage II/III breast cancer: the Korean Cancer Study Group BR 07-01. (PubMed id 22094934)1 Im S.A....Ha S.W. (Breast Cancer Res. Treat. 2012)
    877. HER-2/neu and TOPIIa expression in gastric cancer reflect disease severity. (PubMed id 22281973)1 Liu H.Q....Song S. (Hepatogastroenterology 2012)
    878. High serum HER2 extracellular domain levels: correlation with a worse disease-free survival and overall survival in primary operable breast cancer patients. (PubMed id 22116318)1 Kong Y....Xie X. (J. Cancer Res. Clin. Oncol. 2012)
    879. ER, HER2, and TOP2A expression in primary tumor, synchronous axillary nodes, and asynchronous metastases in breast cancer. (PubMed id 21667123)1 Jensen J.D....Laenkholm A.V. (Breast Cancer Res. Treat. 2012)
    880. Target-specific, histology-independent, randomized discontinuation study of lapatinib in patients with HER2-amplified solid tumors. (PubMed id 20857170)1 Galsky M.D....Zaks T.Z. (Invest New Drugs 2012)
    881. Her-2/neu gene amplification and over-expression in stomach and esophageal adenocarcinoma: from pathology to treatment. (PubMed id 21783379)1 Maresch J....Hejna M. (Crit. Rev. Oncol. Hematol. 2012)
    882. Alterations in epidermal growth factor receptors 1 and 2 in esophageal squamous cell carcinomas. (PubMed id 23207070)1 Gonzaga I.M....Pinto L.F. (BMC Cancer 2012)
    883. EGFR, HER2, survivin, and loss of pSTAT3 characterize high-grade malignancy in salivary gland cancer with impact on prognosis. (PubMed id 22154363)1 Ettl T....Schwarz S. (Hum. Pathol. 2012)
    884. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    885. Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing. (PubMed id 21097718)2 Zang Z.J.... Tan P. (Cancer Res. 2011)
    886. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    887. IQGAP1 protein binds human epidermal growth factor receptor 2 (HER2) and modulates trastuzumab resistance. (PubMed id 21724847)1 White C.D....Sacks D.B. (J. Biol. Chem. 2011)
    888. Molecular dynamics analysis of conserved hydrophobic and hydrophilic bond-interaction networks in ErbB family kinases. (PubMed id 21426301)1 Shih A.J....Radhakrishnan R. (Biochem. J. 2011)
    889. Function of erbB receptors and DNA-PKcs on phosphorylation of cytoplasmic and nuclear Akt at S473 induced by erbB1 ligand and ionizing radiation. (PubMed id 21723633)1 Toulany M....Rodemann H.P. (Radiother Oncol 2011)
    890. Heterogeneous amplification of ERBB2 in primary lesions is responsible for the discordant ERBB2 status of primary and metastatic lesions in gastric carcinoma. (PubMed id 22092393)1 Kim M.A....Kim W.H. (Histopathology 2011)
    891. Inactivation of Rac1 reduces Trastuzumab resistance in PTEN deficient and insulin-like growth factor I receptor overexpressing human breast cancer SKBR3 cells. (PubMed id 21943825)1 Zhao Y....Yang C. (Cancer Lett. 2011)
    892. Expression of activated HER2 in human testes. (PubMed id 21550039)1 Shin I....Park H.Y. (Fertil. Steril. 2011)
    893. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    894. HER2 overcomes PTEN (loss)-induced senescence to cause aggressive prostate cancer. (PubMed id 21930937)1 Ahmad I....Leung H.Y. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    895. [Association of HER2 protein expression with clinicopathologic features and prognosis in Chinese patients with gastric carcinoma]. (PubMed id 21756821)1 Wu H.M....Lin X.T. (Zhonghua Bing Li Xue Za Zhi 2011)
    896. HER2 and TOP2A as predictive markers for anthracycline-containing chemotherapy regimens as adjuvant treatment of breast cancer: a meta-analysis of individual patient data. (PubMed id 21917518)1 Di Leo A....Buyse M. (Lancet Oncol. 2011)
    897. Human epidermal growth factor receptor 2 (HER2) in salivary gland carcinomas. (PubMed id 21670724)1 Clauditz T.S....Wilczak W. (Pathology 2011)
    898. Serum HER2/ECD value in stage I and II early breast cancer: need of a lower cut-off? (PubMed id 22113445)1 Badzek S....Mihaljevic Z. (Wien. Klin. Wochenschr. 2011)
    899. The ErbB3 binding protein EBP1 regulates ErbB2 protein levels and tamoxifen sensitivity in breast cancer cells. (PubMed id 20379846)1 Lu Y....Hamburger A.W. (Breast Cancer Res. Treat. 2011)
    900. EGFR, HER2 and HER3 expression in primary colorectal carcinomas and corresponding metastases: Implications for targeted radionuclide therapy. (PubMed id 21109951)1 Wei Q....Carlsson J. (Oncol. Rep. 2011)
    901. Simultaneous measurement of ERI+, HER2, and phosphoERK1/2 in breast cancer cell lines by flow cytometry. (PubMed id 21607585)1 Bayraktar U.D....Komanduri K.V. (Breast Cancer Res. Treat. 2011)