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ERBB2 Gene

protein-coding   GIFtS: 79
GCID: GC17P037844

V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog...

(Previous name: v-erb-b2 avian erythroblastic leukemia viral oncogene homolog...)
(Previous symbol: NGL)
Microbiology & Infectious Diseases Congress
  See related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 21 2     CD3402
NGL1 2 3 5     HER-22
HER22 3 5     HER-2/neu2
NEU2 3 5     TKR12
Neuro/Glioblastoma Derived Oncogene Homolog1 2     C-Erb B2/Neu Protein2
Metastatic Lymph Node Gene 19 Protein2 3     herstatin2
Proto-Oncogene C-ErbB-22 3     Neuroblastoma/Glioblastoma Derived Oncogene Homolog2
Proto-Oncogene Neu2 3     Receptor Tyrosine-Protein Kinase ErbB-22
Tyrosine Kinase-Type Cell Surface Receptor HER22 3     V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2,
Neuro/Glioblastoma Derived Oncogene Homolog2
MLN 192 3     MLN193
p185erbB22 3     CD340 Antigen3
EC 8     EC 2.7.108
V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2
(Neuro/Glioblastoma Derived Oncogene Homolog)1

External Ids:    HGNC: 34301   Entrez Gene: 20642   Ensembl: ENSG000001417367   OMIM: 1648705   UniProtKB: P046263   

Export aliases for ERBB2 gene to outside databases

Previous GC identifers: GC17P037262 GC17P039854 GC17P037766 GC17P038231 GC17P035109 GC17P033638

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ERBB2 Gene:
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This
protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind
tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and
enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated
protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of
isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655,
shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including
breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding
different isoforms and others that have not been fully characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for ERBB2 Gene: 
ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2) is a protein-coding gene. Diseases associated with ERBB2 include breast scirrhous carcinoma, and lipid-rich carcinoma, and among its related super-pathways are ErbB signaling pathway and Glioma. GO annotations related to this gene include protein C-terminus binding and protein heterodimerization activity. An important paralog of this gene is SYK.

UniProtKB/Swiss-Prot: ERBB2_HUMAN, P04626
Function: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently
needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins
do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and
stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway
elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation
of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the
localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization
Function: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in
the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the
function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein
synthesis and cell growth

summary for ERBB2 Gene:
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members
of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4).
EGFR signaling is initiated by ligand binding to the extracellular ligand binding domain. This initiates
receptor homo-/hetero-dimerization and autophosphorylation by the intracellular kinase domain, resulting in
receptor activation. Following activation, phosphorylation of cytoplasmic substrates occurs and a signaling
cascade is initiated that drives many cellular responses, including changes in gene expression, cytoskeletal
rearrangement, anti-apoptosis and increased cell proliferation.

Gene Wiki entry for ERBB2 (HER2/neu) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ERBB2 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ERBB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ERBB2

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ERBB2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2-q12

ERBB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ERBB2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P037844:  view genomic region     (about GC identifiers)

37,844,167 bp from pter      End:
37,886,679 bp from pter
42,513 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ERBB2_HUMAN, P04626 (See protein sequence)
Recommended Name: Receptor tyrosine-protein kinase erbB-2 precursor  
Size: 1255 amino acids; 137910 Da
Subunit: Homodimer. Heterodimer with EGFR, ERBB3 and ERBB4. Part of a complex with EGFR and either PIK3C2A or
PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with PRKCABP and PLXNB1. Interacts
(when phosphorylated on Tyr-1248) with MEMO1. Interacts with MUC1; the interaction is enhanced by heregulin
(HRG). Interacts (when phosphorylated on Tyr-1139) with GRB7 (via SH2 domain). Interacts (when phosphorylated on
Tyr-1248) with ERBB2IP. Interacts with KPNB1, RANBP2, EEA1, CRM1, CLTC, PTK6, RPA94 and ACTB. Interacts with SRC
(By similarity)
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear
region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is
mediated by importin beta-1/KPNB1
Subcellular location: Isoform 2: Cytoplasm. Nucleus
Subcellular location: Isoform 3: Cytoplasm. Nucleus
6/17 PDB 3D structures from and Proteopedia for ERBB2 (see all 17):
1MFG (3D)        1MFL (3D)        1MW4 (3D)        1N8Z (3D)        1OVC (3D)        1QR1 (3D)    
Secondary accessions: B2RZG3 B4DHN3 Q14256 Q6LDV1 Q9UMK4
Alternative splicing, Alternative initiation: 4 isoforms:  P04626-1   P04626-2   P04626-3   P04626-4   (Produced by alternative splicing of isoform 1)

Explore the universe of human proteins at neXtProt for ERBB2: NX_P04626

Explore proteomics data for ERBB2 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues. Autophosphorylation occurs in
    trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Signaling
    via SEMA4C promotes phosphorylation at Tyr-1248
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04626

  • 4/35 DME Specific Peptides for ERBB2 (P04626) (see all 35)

    ERBB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ERBB2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001005862.1  NP_004439.2  

    ENSEMBL proteins: 
     ENSP00000462438   ENSP00000462808   ENSP00000404047   ENSP00000463714   ENSP00000462024  
     ENSP00000463427   ENSP00000269571   ENSP00000463719   ENSP00000462270   ENSP00000464420  
     ENSP00000464252   ENSP00000463002   ENSP00000446466   ENSP00000385185   ENSP00000443562  
    Reactome Protein details: P04626
    Human Recombinant Protein Products for ERBB2: 
    EMD Millipore Purified and/or Recombinant ERBB2 Protein
    R&D Systems Recombinant & Natural Proteins for ERBB2 (ErbB2/Her2)
    Enzo Life Sciences proteins for ERBB2
    OriGene Purified Proteins for ERBB2
    OriGene Protein Over-expression Lysate for ERBB2
    OriGene MassSpec for ERBB2 
    OriGene Custom Protein Services for ERBB2
    GenScript Custom Purified and Recombinant Proteins Services for ERBB2
    Novus Biologicals ERBB2 Proteins
    Novus Biologicals ERBB2 Lysate
    Sino Biological Recombinant Protein for ERBB2
    Sino Biological Cell Lysate for ERBB2 
    ProSpec Recombinant Protein for ERBB2
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16314522
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--
    GO:0010008endosome membrane IDA16314522
    GO:0016020membrane ----

    ERBB2 for ontologies           About GeneDecksing

    ERBB2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ERBB2
    R&D Systems Antibodies for ERBB2 (ErbB2/Her2)
    Cell Signaling Technology (CST) Antibodies for ERBB2  (HER2)
    OriGene Antibodies for ERBB2
    OriGene Custom Antibody Services for ERBB2
    GenScript Superior Antibodies for ERBB2
    Novus Biologicals ERBB2 Antibodies
    Abcam antibodies for ERBB2
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for ERBB2
    LSBio Antibodies in human, mouse, rat for ERBB2 

    Assay Products for ERBB2: 
    EMD Millipore Kits and Assays for the Analysis of ERBB2
    OriGene Custom Assay Services for ERBB2
    R&D Systems ELISAs for ERBB2 (ErbB2/Her2)         (see all)
    GenScript Custom Assay Services for ERBB2
    Cell Signaling Technology (CST) Sandwich ELISA Kits for ERBB2 (HER2)
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    IUPHAR Guide to PHARMACOLOGY protein family classification: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 
    ErbB (epidermal growth factor) receptor family

    5/11 InterPro protein domains (see all 11):
     IPR017441 Protein_kinase_ATP_BS
     IPR006212 Furin_repeat
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR000494 EGF_rcpt_L

    Graphical View of Domain Structure for InterPro Entry P04626

    ProtoNet protein and cluster: P04626

    5 Blocks protein domains:
    IPB000494 Epidermal growth-factor receptor (EGFR)
    IPB004019 YLP motif
    IPB006211 Furin-like cysteine rich region
    IPB006212 Furin-like repeat
    IPB008266 Tyrosine protein kinase

    UniProtKB/Swiss-Prot: ERBB2_HUMAN, P04626
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily
    Similarity: Contains 1 protein kinase domain

    ERBB2 for domains           About GeneDecksing

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ERBB2_HUMAN, P04626
    Function: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently
    needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins
    do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and
    stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway
    elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation
    of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the
    localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization
    Function: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in
    the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the
    function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein
    synthesis and cell growth
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Activated by dimerization. Not activated by EGF, TGF-alpha and amphiregulin. Interaction with
    PTK6 increases its intrinsic kinase activity

         Genatlas biochemistry entry for ERBB2:
    avian erythroblastic leukemia viral (v-erb-b) oncogene homolog 2,HERC2/neu receptor tyrosine
    kinase,neuroglioblastoma derived,constitutively acting as a coreceptor for multiple stroma-derived growth factors
    i.e EGF-like ligands and neuregulins after heterodimerization with other ERBBs,involved in androgen receptor
    transactivation of inducing prostate-specific antigen (PSA) through the MAP kinase pathway,signal transducer,also
    presenting as a secreted transcript herstatin,expressed in normal fetal kidney and liver,potential inhibitor of
    ERBB2,commonly amplified in primary breast cancer and in endometrial cancer,coamplified with GRB7 in primary
    gastric cancer,and in prostate carcinoma with metastasis and poor prognosis

         Enzyme Numbers (IUBMB): EC 2 EC 2.7.102

         Gene Ontology (GO): 5/17 molecular function terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001042RNA polymerase I core binding IDA--
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity TAS--
    GO:0004714transmembrane receptor protein tyrosine kinase activity IDA7514177
    GO:0004716receptor signaling protein tyrosine kinase activity IEA--
    ERBB2 for ontologies           About GeneDecksing

         2 GenomeRNAi human phenotypes for ERBB2:
     Decreased focal adhesion (FA)   Decreased viability with pacli 

         15/19 MGI mutant phenotypes (inferred from 17 alleles(MGI details for Erbb2) (see all 19):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  homeostasis/metabolism  integument 
     limbs/digits/tail  mortality/aging  muscle  nervous system  normal 

    ERBB2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ERBB2: Erbb2tm1Vrtn Erbb2tm1Gne Erbb2tm2Mul Erbb2tm1Haus Erbb2tm2.1Cbm

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ERBB2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ERBB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ERBB2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ERBB2 

    miRTarBase miRNAs that target ERBB2:
    hsa-mir-125b (MIRT002939), hsa-mir-331-3p (MIRT005805), hsa-mir-125a-5p (MIRT005118), hsa-mir-559 (MIRT000036), hsa-mir-21 (MIRT004318), hsa-mir-548d-3p (MIRT000037)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ERBB2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate ERBB2 (see all 11):
    hsa-miR-548d-3p hsa-miR-3664-5p hsa-miR-452* hsa-miR-3921 hsa-miR-221* hsa-miR-146a* hsa-miR-593 hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidERBB2 3' UTR sequence
    Inhib. RNA
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ERBB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ERBB2

    Gene Editing
    DNA2.0 Custom Protein Engineering Service for ERBB2
    Sirion Biotech Customized adenovirus for overexpression of ERBB2

    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ERBB2 (see all 15)
    OriGene ORF clones in mouse, rat for ERBB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ERBB2 (NM_004448)
    Sino Biological Human cDNA Clone for ERBB2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERBB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERBB2
    Sirion Biotech Customized lentivirus for stable overexpression of ERBB2 
                         Customized lentivirus expression plasmids for stable overexpression of ERBB2 

    Cell Line
    GenScript Custom overexpressing Cell Line Services for ERBB2
    Search LifeMap BioReagents cell lines for ERBB2
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERBB2

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ERBB2 About   (see all 58)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52
    Non-small cell lung cancer0.51
    Signaling Pathways in Glioblastoma0.36
    Prostate cancer0.39
    Bladder cancer0.31
    3SHC1 events in ERBB2 signaling
    SHC1 events in ERBB2 signaling0.92
    ErbB receptor signaling network0.34
    GRB2 events in ERBB2 signaling0.92
    4Development EGFR signaling pathway
    Development EGFR signaling pathway0.87
    EGF Pathway0.41
    Development ERBB-family signaling0.57
    5Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/8 EMD Millipore Pathways for ERBB2 (see all 8)
        Apoptosis and survival Role of CDK5 in neuronal death and survival
    Development EGFR signaling pathway
    Development TGF-beta receptor signaling
    Translation Non-genomic (rapid) action of Androgen Receptor
    Development Ligand-independent activation of ESR1 and ESR2

    1 R&D Systems Pathway for ERBB2
        Akt Signaling Pathway

    5/38 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ERBB2 (see all 38)
        Paxillin Interactions
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    JNK Pathway
    Tec Kinases Signaling

    1 Cell Signaling Technology (CST) Pathway for ERBB2
        Tyrosine Kinases / Adaptors

    4 Tocris Bioscience Pathways for ERBB2
        Akt Pathway
    Apoptosis Pathway
    NF-kappaB Pathway
    MAPK Pathway

    5/8 GeneGo (Thomson Reuters) Pathways for ERBB2 (see all 8)
        Development ERBB-family signaling
    Development Ligand-independent activation of ESR1 and ESR2
    Apoptosis and survival Role of CDK5 in neuronal death and survival
    Development EGFR signaling via PIP3
    Development EGFR signaling pathway

    5/14 BioSystems Pathways for ERBB2 (see all 14)
        Focal Adhesion
    DNA damage response (only ATM dependent)
    ErbB signaling pathway
    Signaling Pathways in Glioblastoma
    Alpha6-Beta4 Integrin Signaling Pathway

    1 Sino Biological Pathway for ERBB2 
        EGFR Signaling Pathway

    5/41        Reactome Pathways for ERBB2 (see all 41)
        Signaling by EGFR in Cancer
    Downregulation of ERBB2:ERBB3 signaling
    Downstream signal transduction
    Signal Transduction
    Signaling by PDGF

    1 PharmGKB Pathway for ERBB2
        EGFR Inhibitor Pathway, Pharmacodynamics

    5/13         Kegg Pathways  (Kegg details for ERBB2) (see all 13):
        ErbB signaling pathway
    Calcium signaling pathway
    HIF-1 signaling pathway
    Focal adhesion
    Adherens junction

    ERBB2 for pathways           About GeneDecksing


        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ERBB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/230 Interacting proteins for ERBB2 (P046261, 2, 3 ENSP000002695714) via UniProtKB, MINT, STRING, and/or I2D (see all 230)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SHC1P293532, 3, ENSP000004013034MINT-61510 MINT-61506 MINT-74737 MINT-61504 MINT-74734 MINT-74736 MINT-61508 MINT-74733 MINT-74735 MINT-61511 I2D: score=8 STRING: ENSP00000401303
    PIK3R3Q925692, 3, ENSP000002627414MINT-74664 MINT-74642 MINT-74650 MINT-74662 MINT-74660 MINT-74649 MINT-74663 MINT-74641 MINT-74661 I2D: score=2 STRING: ENSP00000262741
    PIK3R2O004592, 3, ENSP000002222544MINT-74622 MINT-74623 MINT-74620 MINT-74631 MINT-74621 MINT-61505 MINT-74632 I2D: score=5 STRING: ENSP00000222254
    SYKP434052, 3, ENSP000003648984MINT-74765 MINT-74767 MINT-74769 MINT-74758 MINT-74768 MINT-74764 MINT-74766 I2D: score=2 STRING: ENSP00000364898
    ABL2P426842, 3, ENSP000003565954MINT-74443 MINT-74440 MINT-74444 MINT-74442 MINT-74439 MINT-74441 I2D: score=2 STRING: ENSP00000356595
    About this table

    Gene Ontology (GO): 5/38 biological process terms (GO ID links to tree view) (see all 38):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation ISS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006468protein phosphorylation TAS10851066
    GO:0007165signal transduction IDA10572067
    GO:0007166cell surface receptor signaling pathway IDA9685399

    ERBB2 for ontologies           About GeneDecksing

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ERBB2 for compounds           About GeneDecksing

    EMD Millipore small molecules for ERBB2:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for ERBB2

    Compounds for ERBB2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Iressa Orally active, selective EGFR inhibitor [184475-35-2]
    AG 490 EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor [133550-30-8]
    JNJ 28871063 hydrochloridePotent ErbB receptor family inhibitor[944341-54-2]
    AG 1478 hydrochlorideHighly potent EGFR-kinase inhibitor[153436-53-4]
    GenisteinEGFR kinase inhibitor. Also estrogen and PPARgamma ligand[446-72-0]

    2 HMDB Compounds for ERBB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    5 DrugBank Compounds for ERBB2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    LapatinibFMM (see all 5)388082-78-8targetantagonist15163842 14751502 16894399 20110044 12214266 18803986 14967461 14737100 11752352 20658522 15374980 14633707
    TrastuzumabAnti HER2 (see all 2)180288-69-1targetantibody17660958 11752352 18690878 11098307
    ado-trastuzumab emtansineRG-3502 (see all 4)1018448-65-targetantibody23196784 11752352 19010901
    Pertuzumab2C4 Antibody (see all 6)380610-27-5targetantibody15093539
    Afatinib-- 850140-72-6targetinhibitor--

    10/125 Novoseek inferred chemical compound relationships for ERBB2 gene (see all 125)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trastuzumab 97.1 2051 16865596 (9), 16161043 (7), 16384610 (7), 15780499 (6) (see all 99)
    lapatinib 91.7 285 17635524 (6), 18413839 (5), 19309723 (5), 19060928 (4) (see all 99)
    estrogen 88.7 1465 7591267 (7), 1680817 (6), 7647336 (6), 12375012 (5) (see all 99)
    progesterone 87.8 1122 1345772 (5), 15743737 (5), 16085689 (4), 15979129 (4) (see all 99)
    cb 11 87.4 81 16373062 (4), 11759828 (3), 12669615 (2), 19305385 (2) (see all 54)
    tyrosine 86.1 1292 1706346 (7), 16287490 (6), 11774167 (6), 11526509 (5) (see all 99)
    pertuzumab 84.5 77 19920829 (6), 15093539 (4), 17635517 (3), 17237269 (3) (see all 32)
    gefitinib 82.5 175 17487844 (5), 17638894 (5), 11751413 (4), 12860941 (3) (see all 70)
    tamoxifen 76.8 327 11774281 (6), 15319565 (6), 17636399 (6), 11032587 (6) (see all 99)
    erlotinib 74.7 38 17283159 (3), 17094474 (3), 16373709 (2), 20130423 (1) (see all 23)

    5 PharmGKB related drug/compound annotations for ERBB2 gene    About this table
    Drug/compound PharmGKB Annotation
    trastuzumab  CA  
    trastuzumab emtansine

    Search CenterWatch for drugs/clinical trials and news about ERBB2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ERBB2 gene (2 alternative transcripts): 
    NM_001005862.1  NM_004448.2  

    Unigene Cluster for ERBB2:

    V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
    Hs.446352  [show with all ESTs]
    Unigene Representative Sequence: NM_001005862
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000584601 ENST00000584014 ENST00000578199(uc002hsl.3) ENST00000445658
    ENST00000584450 ENST00000582648 ENST00000582788 ENST00000578373 ENST00000269571
    ENST00000584908(uc002hsn.1) ENST00000578709 ENST00000584099 ENST00000583038
    ENST00000583391 ENST00000578502 ENST00000582818 ENST00000578630 ENST00000584684

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ERBB2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate ERBB2 (see all 11):
    hsa-miR-548d-3p hsa-miR-3664-5p hsa-miR-452* hsa-miR-3921 hsa-miR-221* hsa-miR-146a* hsa-miR-593 hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidERBB2 3' UTR sequence
    Inhib. RNA
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ERBB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ERBB2
    OriGene clones in human, mouse for ERBB2 (see all 15)
    OriGene ORF clones in mouse, rat for ERBB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ERBB2 (NM_004448)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERBB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERBB2
    Sirion Biotech Customized lentivirus for stable overexpression of ERBB2 
                         Customized lentivirus expression plasmids for stable overexpression of ERBB2 
    OriGene qSTAR qPCR primer pairs in human, mouse for ERBB2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ERBB2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ERBB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ERBB2

    Additional mRNA sequence: 

    AB025286.1 AF177761.2 AK296908.1 AK300321.1 AK309029.1 AK313683.1 BC080193.1 BC110392.1 
    BC167147.1 HM437238.1 M11730.1 S57296.1 X03363.1 

    24/26 DOTS entries (see all 26):

    DT.100824047  DT.95088838  DT.120977168  DT.215753  DT.75117810  DT.97759791  DT.120977079  DT.95261294 
    DT.100824051  DT.100824052  DT.70100272  DT.100824048  DT.75167343  DT.95256387  DT.75191397  DT.91699968 
    DT.91727209  DT.92025980  DT.95090252  DT.100731961  DT.100738418  DT.120977138  DT.120977177  DT.40278576 

    24/323 AceView cDNA sequences (see all 323):

    CA455074 AI859972 BM830170 CA487981 BI755753 BM758528 BF083392 BM692355 
    AA025156 CB129403 CA488792 BE746725 AU140362 AI280566 BM787824 AI671621 
    AW175631 BM795191 BM721340 AW175620 BM829991 AB025286 BU845391 CA435933 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ERBB2 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:                    -                                                                                   -                                                   
    SP2:                                                                                                        -                                                   
    SP3:                    -                                                                                                                                       
    SP4:                                                                                                                          -                                 

    ExUns: 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27a · 27b

    ECgene alternative splicing isoforms for ERBB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ERBB2 expression in normal human tissues (normalized intensities)      ERBB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    ERBB2 Expression
    About this image

    ERBB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     Nose (Sensory Organs)    fully expand to see all 5 entries
             sensory organ/nose/naso-lacrimal duct   
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             spinal cord/lateral wall/ventricular layer   
     Peripheral Nervous System (Nervous System)    fully expand to see all 4 entries
             Immature Schwann Cells Peripheral Nerve Domain
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Endocardial Cushion Cells Atrioventricular Endocardial Cushion
     Tooth (Integumentary System)    fully expand to see all 4 entries
             visceral organ/oral region/upper jaw   

    See ERBB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ERBB2

    SOURCE GeneReport for Unigene cluster: Hs.446352

    UniProtKB/Swiss-Prot: ERBB2_HUMAN, P04626
    Tissue specificity: Expressed in a variety of tumor tissues including primary breast tumors and tumors from small
    bowel, esophagus, kidney and mouth

        SABiosciences Expression via Pathway-Focused PCR Arrays including ERBB2 (see all 13): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Neurogenesis in human mouse rat
              Lung Cancer in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              Angiogenesis in human mouse rat

    OriGene qSTAR qPCR primer pairs in human, mouse for ERBB2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ERBB2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ERBB2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ERBB2
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERBB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ERBB2 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Erbb21 , 5 v-erb-b2 erythroblastic leukemia viral oncogene homolog more1, 5 85.6(n)1
      11 (61.75 cM)5
    138661  NM_001003817.11  NP_001003817.11 
    (Gallus gallus)
    Aves ERBB21 v-erb-b2 erythroblastic leukemia viral oncogene homolog more 73.11(n)
      426130  NM_001044661.1  NP_001038126.1 
    (Anolis carolinensis)
    Reptilia ERBB26
    Uncharacterized protein
    1 ↔ 1
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.143902 Xenopus laevis transcribed sequence with moderate similarity more 76.71(n)    BM192617.1 
    (Danio rerio)
    Actinopterygii erbb21 v-erb-b2 erythroblastic leukemia viral oncogene homolog more 60.69(n)
      386966  NM_200119.2  NP_956413.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Egfr3 eggshell pattern formation epidermal
    growth factor more
    39(a)     --

    ENSEMBL Gene Tree for ERBB2 (if available)
    TreeFam Gene Tree for ERBB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68)
    About This Section
    Paralogs for ERBB2 gene
    SYK2  TNK12  JAK32  JAK22  TNK22  TYK22  ERBB42  JAK12  
    ERBB32  PTK22  ZAP702  EGFR2  PTK2B2  
    18/114 SIMAP similar genes for ERBB2 using alignment to 16 protein entries:     ERBB2_HUMAN (see all proteins) (see all similar genes):
    WARS    HER-2    TNFRSF17    TSEN2    ZNF564    ZNF737
    CRCP    ZNF100    EPHA4    APOD    FAM175A    HKR1
    LOC100506792    NF2    UTY    ZNF738    CHID1    HMGA2

    ERBB2 for paralogs           About GeneDecksing

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: ERBB2_HUMAN, P04626
    Polymorphism: There are four alleles due to the variations in positions 654 and 655. Allele B1 (Ile-654/Ile-655)
    has a frequency of 0.782; allele B2 (Ile-654/Val-655) has a frequency of 0.206; allele B3 (Val-654/Val-655) has a
    frequency of 0.012

    10/1038 SNPs in ERBB2 are shown (see all 1038)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 17 posSequence#AA
    A lung adenocarcinoma sample4--see VAR_0554322 L P mis40--------
    CA gastric adenocarcinoma sample4 other138668203(+) TGGCTA/GGTGTG 4 S G mis1 ese30--------
    CAn ovarian cancer sample4 other138668584(+) TCCCAA/GCCATG 4 N S mis1 ese30--------
    CA glioblastoma sample4 other138669180(+) TGTGGA/GAGCTG 4 K E mis10--------
    C,Fnon-pathogenic138666791(+) CGTCCA/GTCATC 4 I V mis19Minor allele frequency- G:0.01MN NA EU 6283
    C,F,Hnon-pathogenic138666794(+) CCATCA/G/TTCTCT 4 I V mis146EA NS NA MN CSA EU 11776
    Cuntested138659357(+) CGCACC/G/TAAGCT 4 Q * stg11NA 4546
    ----see VAR_0163182 P A mis40--------
    --33641664(+) AAAAAA/TATATA 1 -- int10--------
    C--33642047(+) ATATA-/AT/CA 
    1 -- int10--------

    HapMap Linkage Disequilibrium report for ERBB2 (37844167 - 37886679 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ERBB2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2048CNV Insertion18451855
    nsv908219CNV Loss21882294
    nsv908207CNV Loss21882294
    esv275276CNV Loss21479260
    nsv528093CNV Loss19592680
    dgv3162n71CNV Loss21882294
    dgv40n68CNV Loss17160897
    nsv908214CNV Loss21882294
    dgv3165n71CNV Gain21882294
    esv274928CNV Gain+Loss21479260

    Human Gene Mutation Database (HGMD): ERBB2
    5/21 SABiosciences Cancer Mutation PCR Assays for ERBB2 (see all 21):
    Cosmic IdAA Change
    5/11 SABiosciences Cancer Mutation PCR Arrays containing ERBB2 (see all 11):
    ErbB2/HER2/neu Pathway
    Ovarian Cancer
    Cancer Comprehensive Panel 384HT
    Lung Cancer
    Oncogene Panel 384HT
    4 SABiosciences qBiomarker Copy Number PCR Arrays containing ERBB2:
    Oncogenes & Tumor Suppressor Genes 384HC
    Breast Cancer
    WNT Signaling
    Kinases & Phosphatases
    SeqTarget long-range PCR primers for resequencing ERBB2
    DNA2.0 Custom Variant and Variant Library Synthesis for ERBB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 164870   
    OMIM disorders: 211980  137800  137215  
    UniProtKB/Swiss-Prot: ERBB2_HUMAN, P04626
  • Hereditary diffuse gastric cancer (HDGC) [MIM:137215]: A cancer predisposition syndrome with increased
    susceptibility to diffuse gastric cancer. Diffuse gastric cancer is a malignant disease characterized by poorly
    differentiated infiltrating lesions resulting in thickening of the stomach. Malignant tumors start in the
    stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby
    lymph nodes and organs. It also can metastasize to other parts of the body. Note=The gene represented in this
    entry is involved in disease pathogenesis
  • Glioma (GLM) [MIM:137800]: Gliomas are benign or malignant central nervous system neoplasms derived from
    glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes,
    oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. Note=The gene
    represented in this entry is involved in disease pathogenesis
  • Ovarian cancer (OC) [MIM:167000]: The term ovarian cancer defines malignancies originating from ovarian
    tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the
    most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of
    late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry
  • Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form
    of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes:
    squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced
    stage and has a poor prognosis. Note=The gene represented in this entry is involved in disease pathogenesis
  • Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the
    esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It
    also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to
    adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types
    are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated
    infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually
    exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in
    sporadic disease. Note=The gene represented in this entry is involved in disease pathogenesis
  • Note=Chromosomal aberrations involving ERBB2 may be a cause gastric cancer. Deletions within 17q12 region
    producing fusion transcripts with CDK12, leading to CDK12-ERBB2 fusion leading to truncated CDK12 protein not
    in-frame with ERBB2

  • 20/208 diseases for ERBB2 (see all 208):    About MalaCards
    breast scirrhous carcinoma    lipid-rich carcinoma    glioblastoma, somatic    ductal carcinoma in situ
    transitional cell carcinoma    glioblastoma    uterine carcinosarcoma    hidradenocarcinoma
    invasive bladder transitional cell carcinoma    sclerosing adenosis of breast    glassy cell carcinoma of the cervix    apocrine adenosis of breast
    adenocarcinoma of lung, somatic    papillary serous adenocarcinoma    bladder transitional cell carcinoma    fallopian tube cancer
    progesterone-receptor negative breast cancer    progesterone-receptor positive breast cancer    female breast carcinoma    mammary paget's disease

    14 diseases from the University of Copenhagen DISEASES database for ERBB2:
    Breast cancer     Carcinoma     Ductal carcinoma in situ     Ovarian cancer
    Lung cancer     Endometrial cancer     Prostate cancer     Neutropenia
    Urinary bladder cancer     Colorectal cancer     Pancreatic cancer     Breast disease
    Diarrhea     Stomach cancer

    ERBB2 for disorders           About GeneDecksing

    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/96 Novoseek inferred disease relationships for ERBB2 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 94.7 5501 11489825 (9), 12132871 (7), 12755489 (7), 9363867 (7) (see all 99)
    breast carcinoma 92.4 1090 12973835 (6), 14669272 (6), 11579337 (5), 9698539 (5) (see all 99)
    carcinoma ductal 89.4 268 12481013 (6), 16169726 (4), 15696127 (3), 18681318 (3) (see all 99)
    tumors 88.5 5807 14612517 (8), 9563885 (7), 14696118 (7), 11888924 (7) (see all 99)
    breast cancer metastatic 88.3 404 11820721 (5), 11477443 (4), 15059359 (4), 10467326 (4) (see all 99)
    carcinoma 82.7 1015 12653946 (7), 20208479 (6), 12631216 (6), 18415713 (5) (see all 99)
    cancer 82.5 1385 11774202 (7), 18498074 (7), 16740724 (6), 12942124 (6) (see all 99)
    metastasis 81.3 960 17511881 (8), 15786420 (6), 15150568 (6), 11481385 (5) (see all 99)
    invasive ductal breast carcinoma 76.8 19 17908479 (2), 18390199 (2), 11106082 (1), 11561770 (1) (see all 14)
    carcinoma lobular 75.1 24 9563885 (1), 12152162 (1), 14659337 (1), 1374218 (1) (see all 22)

    Genetic Association Database (GAD): ERBB2
    Human Genome Epidemiology (HuGE) Navigator: ERBB2 (155 documents)
    Tumor Gene Database (TGDB): ERBB2

    Export disorders for ERBB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ERBB2 gene, integrated from 9 sources (see all 5057) (see top 10):
    (articles sorted by number of sources associating them with ERBB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association between HER2, TOP2A, and response to anth racycline-based preoperative chemotherapy in high-risk primary breast cancer. (PubMed id 20130985)1, 4, 9 Konecny G.E....Slamon D.J. (2010)
    2. The genetic polymorphisms of HER-2 and the risk of lung cancer in a Korean population. (PubMed id 19055823)1, 4, 9 Jo U.H....Kim Y.H. (2008)
    3. Epidermal growth factor receptor and human epidermal growth factor receptor 2 gene polymorphisms in endometrial cancer in a Japanese population. (PubMed id 17644807)1, 4, 9 Kitao K....Maruo T. (2007)
    4. EGFR, ERBB2, and KRAS mutations in Korean non-small cell lung cancer patients. (PubMed id 17321325)1, 4, 9 Bae N.C....Park J.Y. (2007)
    5. The influence of HER2 genotypes as molecular markers on breast cancer outcome. (PubMed id 18721072)1, 4, 9 Mutluhan H....Seyrek E. (2008)
    6. Polymorphisms of HER2 Ile655Val and cyclin D1 (CCND1) G870A are not associated with breast cancer risk but polymorphic allele of HER2 is associated with nodal metastases. (PubMed id 18237245)1, 4, 9 Naidu R....Taib N.A. (2008)
    7. The influence of serum HER-2 levels and HER-2 codon 655 polymorphism on breast cancer outcome. (PubMed id 18237248)1, 4, 9 Papadopoulou E....Kortsaris A. (2008)
    8. Impact of HER2 and EGFR gene status on gefitinib-treated patients with nonsmall-cell lung cancer. (PubMed id 17487844)1, 4, 9 Soh J....Date H. (2007)
    9. Topoisomerase II alpha and responsiveness of breast cancer to adjuvant chemotherapy. (PubMed id 19401546)1, 4, 9 O'Malley F.P....Pritchard K.I. (2009)
    10. Role of the HER2 [Ile655Val] genetic polymorphism in tumorogenesis and in the risk of trastuzumab-related cardiotoxicity. (PubMed id 17693647)1, 4, 9 Beauclair S....Milano G. (2007)
    11. Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex. (PubMed id 15093539)2, 7, 9 Franklin M.C....Sliwkowski M.X. (2004)
    12. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. (PubMed id 12610629)1, 2, 9 Cho H.-S.... Leahy D.J. (2003)
    13. Correlations of EGFR mutations and increases in EGFR and HER2 copy number to gefitinib response in a retrospective analysis of lung cancer patients. (PubMed id 17626639)1, 4, 9 Pugh T.J....Marra M.A. (2007)
    14. Estrogen receptor codon 594 and HER2 codon 655 polymorphisms and breast cancer risk. (PubMed id 15126109)1, 4, 9 Akisik E. and Dalay N. (2004)
    15. [Association between HRE-2 gene polymorphism at codon 655 and genetic susceptibility of colorectal cancer] (PubMed id 19504444)1, 4, 9 Liang X....Chen K. (2009)
    16. Outcome of patients with early-stage breast cancer tr eated with doxorubicin-based adjuvant chemotherapy as a function of HER2 and TO P2A status. (PubMed id 19620488)1, 4, 9 Tubbs R....Hayes D.F. (2009)
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    74. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (2008)
    75. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (2008)
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    149. Genistein affects HER2 protein concentration, activation, and promoter regulation in BT-474 human breast cancer cells. (PubMed id 17992604)1, 9 Sakla M.S....Lubahn D.B. (2007)
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    167. Parsing ERK activation reveals quantitatively equivalent contributions from epidermal growth factor receptor and HER2 in human mammary epithelial cells. (PubMed id 15572377)1, 9 Hendriks B.S....Lauffenburger D.A. (2005)
    168. Integrin alpha5/beta1 expression mediates HER-2 down-regulation in colon cancer cells. (PubMed id 15757908)1, 9 Kuwada S.K....Li X. (2005)
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    186. Human epidermal growth factor receptor type 2 protein expression in Chinese metastatic prostate cancer patients correlates with cancer specific survival and increases after exposure to hormonal therapy. (PubMed id 18645672)1, 9 Dai B....Yao X.D. (2008)
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    189. Amplification of TOP2A and HER-2 genes in breast cancers occurring in patients harbouring BRCA1 germline mutations. (PubMed id 17453369)1, 9 Hagen A.I....Lonning P.E. (2007)
    190. Type of TP53 mutation and ERBB2 amplification affects survival in node-negative breast cancer. (PubMed id 17221157)1, 9 Ozcelik H....Andrulis I.L. (2007)
    191. Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium. (PubMed id 17549377)1, 9 Brys M....Krajewska W.M. (2007)
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    198. Cell proliferation, nuclear ploidy, and EGFr and HER2/neu tyrosine kinase oncoproteins in infiltrating ductal breast carcinoma. (PubMed id 12419588)1, 9 Fernandez Val J.F....Sarria R. (2002)
    199. Differential C-erbB-2 and VEGF expression following BCG immunotherapy in superficial papillary transitional cell carcinoma of the bladder. (PubMed id 12474525)1, 9 Morgan B.E....Morgan M.B. (2002)
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    212. Differential regulation of ErbB2 expression by cAMP-dependent protein kinase in tamoxifen-resistant breast cancer cells. (PubMed id 18409049)1, 9 Yang J.W....Kang K.W. (2008)
    213. CXCL12/CXCR4 transactivates HER2 in lipid rafts of prostate cancer cells and promotes growth of metastatic deposits in bone. (PubMed id 18337451)1, 9 Chinni S.R....Cher M.L. (2008)
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    216. Geldanamycin-induced down-regulation of ErbB2 from the plasma membrane is clathrin dependent but proteasomal activity independent. (PubMed id 18337455)1, 9 Pedersen N.M....Stang E. (2008)
    217. HER2 gene amplification and chromosome 17 copy number do not predict survival of patients with resected pancreatic adenocarcinoma. (PubMed id 18463983)1, 9 Sharif S....Krasinskas A.M. (2008)
    218. No strong association between HER-2/neu protein overexpression and gene amplification in high-grade invasive urothelial carcinomas. (PubMed id 18415713)1, 9 Caner V....Duzcan S.E. (2008)
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    222. Prognostic significance of human epidermal growth factor receptor positivity for the development of brain metastasis after newly diagnosed breast cancer. (PubMed id 17102066)1, 9 Gabos Z....Abdulkarim B. (2006)
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    225. Cluster analysis of p-glycoprotein, c-erb-B2 and P53 in relation to tumor histology strongly indicates prognosis in patients with operable non-small cell lung cancer. (PubMed id 15917726)1, 9 Bozcuk H....Savas B. (2005)
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    229. Hyaluronan constitutively regulates ErbB2 phosphorylation and signaling complex formation in carcinoma cells. (PubMed id 15632176)1, 9 Ghatak S....Toole B.P. (2005)
    230. Human epidermal growth factor receptor 2 status modulates subcellular localization of and interaction with estrogen receptor alpha in breast cancer cells. (PubMed id 15173068)1, 9 Yang Z....Kumar R. (2004)
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    306. Lapatinib restores hormone sensitivity with different ial effects on estrogen receptor signaling in cell models of human epidermal gr owth factor receptor 2-negative breast cancer with acquired endocrine resistanc e. (PubMed id 20179226)1, 9 Leary A.F....Johnston S.R. (2010)
    307. Overexpression of c-erbB2 is a negative prognostic fa ctor in anaplastic astrocytomas. (PubMed id 20331873)1, 9 Gulati S....Torp S.H. (2010)
    308. Upregulation of lactate dehydrogenase A by ErbB2 thro ugh heat shock factor 1 promotes breast cancer cell glycolysis and growth. (PubMed id 19668225)1, 9 Zhao Y.H....Tan M. (2009)
    309. The involvement of HER2 and p53 status in the regulat ion of telomerase in irradiated breast cancer cells. (PubMed id 19787269)1, 9 Papanikolaou V....Tsezou A. (2009)
    310. Prognostic impact of HER2/neu protein in urothelial b ladder cancer. Survival analysis of 80 cases and an overview of almost 20 years ' research. (PubMed id 19810139)1, 9 Skagias L....Patsouris E. (2009)
    311. Induction of ERBB2 nuclear transport after radiation in breast cancer cells. (PubMed id 19513620)1, 9 Luo B....Rong L. (2009)
    312. HER2 expression in breast cancer: correlation with en docrine function and psychological status in operable and metastatic breast can cer. (PubMed id 20023245)1, 9 Lissoni P....Bartolacelli E. (2009)
    313. Suppression of ErbB-2 in androgen-independent human p rostate cancer cells enhances cytotoxic effect by gemcitabine in an androgen-re duced environment. (PubMed id 19467571)1, 9 Zhang L....Lin M.F. (2009)
    314. Her-2/neu gene amplification in paraffin-embedded tis sue sections of meningioma patients. (PubMed id 19431122)1, 9 Ozer O....AltinAPrs N. (2009)
    315. Analysis of ErbB receptors in pulmonary carcinoid tumors. (PubMed id 19447869)1, 9 Rickman O.B....Thomas C.F. (2009)
    316. Expression of heregulin, phosphorylated HER-2, HER-3 and HER-4 in HER-2 negative breast cancers. (PubMed id 19148499)1, 9 Haas S....BA1ttner R. (2009)
    317. Serum levels of epidermal growth factor and HER-2 neu in non small-cell lung cancer: prognostic correlation. (PubMed id 19093231)1, 9 Abdel Salam I....Abdel Wahab N. (2009)
    318. 14-3-3zeta Cooperates with ErbB2 to promote ductal ca rcinoma in situ progression to invasive breast cancer by inducing epithelial-me senchymal transition. (PubMed id 19732720)1, 9 Lu J....Yu D. (2009)
    319. Incomplete surgical resection of ductal carcinomas in situ results in activation of ERBB2 in residual breast cancer cells. (PubMed id 18948375)1, 9 Singer C.F....Kubista E. (2009)
    320. ErbB2 and ErbB4 Cbl binding sites can functionally replace the ErbB1 Cbl binding site. (PubMed id 19263517)1, 9 Jansen S.M....van Leeuwen J.E. (2009)
    321. Clinical significance and prognostic value of serum sHER-2/neu levels in patients with solid tumors. (PubMed id 18855148)1, 9 Papila C....Yanardag H. (2009)
    322. Amplification and expression of EGFR and ERBB2 in Wil ms tumor. (PubMed id 19781441)1, 9 Vasei M....Sauter G. (2009)
    323. EGFR and HER2 expression in advanced biliary tract ca ncer. (PubMed id 19777609)1, 9 Harder J....Opitz O.G. (2009)
    324. Metastatic breast cancer survival according to HER2 a nd Topo2a gene status. (PubMed id 19729798)1, 9 TodoroviA8-RakoviA8 N....NikoliA8-VukosavljeviA8 D. (2009)
    325. Impact of HER2 gene and protein status on the treatment outcome of cisplatin-based chemoradiotherapy for locally advanced non-small cell lung cancer. (PubMed id 18448999)1, 9 Kuyama S....Tanimoto M. (2008)
    326. Immunophenotyping of serous carcinoma of the female genital tract. (PubMed id 18567994)1, 9 Nofech-Mozes S....Ghorab Z. (2008)
    327. Age interacts with the expression of steroid and HER-2 receptors in operable invasive breast cancer. (PubMed id 17687649)1, 9 Neven P....Drijkoningen M. (2008)
    328. Macrophage inhibitory cytokine-1 activates AKT and ERK-1/2 via the transactivation of ErbB2 in human breast and gastric cancer cells. (PubMed id 18258606)1, 9 Kim K.K....Lee J.H. (2008)
    329. HER2/neu in systemic therapy for women with breast cancer: a systematic review. (PubMed id 17636396)1, 9 Dhesy-Thind B....Trudeau M. (2008)
    330. A splice variant of HER2 corresponding to Herstatin is expressed in the noncancerous breast and in breast carcinomas. (PubMed id 18592003)1, 9 Koletsa T....Kotoula V. (2008)
    331. An investigation of the differential expression of Her2/neu gene expression in normal oral mucosa, epithelial dysplasia, and oral squamous cell carcinoma in Taiwan. (PubMed id 18364263)1, 9 Fong Y....Kao S.Y. (2008)
    332. Evaluation of the prognostic and predictive value of HER family mRNA expression in high-risk early breast cancer: a Hellenic Cooperative Oncology Group (HeCOG) study. (PubMed id 18985033)1, 9 Koutras A.K....Fountzilas G. (2008)
    333. Protein tyrosine phosphatase PTPN13 negatively regulates Her2/ErbB2 malignant signaling. (PubMed id 17982484)1, 9 Zhu J.H....Lee J.D. (2008)
    334. Expression of c-Myc, neurofibromatosis Type 2, somatostatin receptor 2 and erb-B2 in human meningiomas: relation to grades or histotypes. (PubMed id 18808065)1, 9 Durand A....Fevre-Montange M. (2008)
    335. A critical role for HSP90 in cancer cell invasion involves interaction with the extracellular domain of HER-2. (PubMed id 18056992)1, 9 Sidera K....Patsavoudi E. (2008)
    336. Comparative analysis of c-erbB-2 (HER-2/neu) in squamous cell carcinoma of the tongue: does over-expression exist? And what is its correlation with traditional diagnostic parameters? (PubMed id 18251938)1, 9 Angiero F....Sidoni A. (2008)
    337. Differential expression of fatty acid synthase (FAS) and ErbB2 in nonmalignant and malignant oral keratinocytes. (PubMed id 18528705)1, 9 Silva S.D....Graner E. (2008)
    338. [Correlation between lymph-node metastasis and combined expression of Hpa and C-erbB-2 of invasive ductal breast carcinoma] (PubMed id 18390199)1, 9 Zheng X.D....Mao D.H. (2008)
    339. ErbB-2 via PYK2 upregulates the adhesive ability of androgen receptor-positive human prostate cancer cells. (PubMed id 17563746)1, 9 Yuan T.C....Lin M.F. (2007)
    340. Correlative expression of cyclooxygenase-1 (cox-1) and human epidermal growth factor receptor type-2 (her-2) in endometrial cancer. (PubMed id 18204294)1, 9 Sugimoto T....Nishimura R. (2007)
    341. [Expression of C-erb B-2 and its relation to angiogen esis in nasopharyngeal carcinoma] (PubMed id 17959545)1, 9 Liu Y.M....Li H.G. (2007)
    342. PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib. (PubMed id 18089823)1, 9 Engelman J.A....Janne P.A. (2007)
    343. In situ and invasive components of mammary adenocarcinoma: comparison of Her-2/neu status. (PubMed id 17879632)1, 9 Layfield L.J. and Lewis C. (2007)
    344. Overexpression of HER-2/neu oncogene and transitional cell carcinoma of bladder. (PubMed id 17987577)1, 9 Jalali Nadoushan M.R....Zaeri F. (2007)
    345. [Expressions and significances of EGFR, C-erbB2 and Ki-67 in nasal squamous cell carcinomas] (PubMed id 17674766)1, 9 Li J....Guo L. (2007)
    346. Potential for molecular-targeted therapy targeting human epidermal growth factor receptor-2 for invasive bladder cancer. (PubMed id 17549338)1, 9 Yamada Y....Honda N. (2007)
    347. Associations between Notch-2, Akt-1 and HER2/neu expression in invasive human breast cancer: a tissue microarray immunophenotypic analysis on 98 patients. (PubMed id 18087195)1, 9 Florena A.M....Franco V. (2007)
    348. Wwox suppresses prostate cancer cell growth through modulation of ErbB2-mediated androgen receptor signaling. (PubMed id 17704139)1, 9 Qin H.R....Huebner K. (2007)
    349. A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer. (PubMed id 16682622)1, 9 Xia W....Spector N.L. (2006)
    350. Differential expression of STAT5 and Bcl-xL, and high expression of Neu and STAT3 in non-small-cell lung carcinoma. (PubMed id 16959370)1, 9 Sanchez-Ceja S.G....Gutierrez-Castellanos S. (2006)
    351. HER 2/neu protein expression in colorectal cancer. (PubMed id 16681853)1, 9 Schuell B....Wrba F. (2006)
    352. HER-2 status determination in breast carcinomas. A practical approach. (PubMed id 16372244)1, 9 Garcia-Caballero T....Fraga M. (2006)
    353. Lapatinib: a novel EGFR/HER2 tyrosine kinase inhibitor for cancer. (PubMed id 16894399)7, 9 Johnston S.R. and Leary A. (2006)
    354. A high-throughput migration assay reveals HER2-mediated cell migration arising from increased directional persistence. (PubMed id 16782798)1, 9 Kumar N....Lauffenburger D.A. (2006)
    355. Differential c-erbB-1 and c-erbB-2 mRNA expression in cancer of the pancreas compared with cancer of the papilla of Vater. (PubMed id 16489645)1, 9 Prenzel K.L....Schneider P.M. (2006)
    356. HER2 status in pure ductal carcinoma in situ and in the intraductal and invasive components of invasive ductal carcinoma determined by fluorescence in situ hybridization and immunohistochemistry. (PubMed id 16681686)1, 9 Park K....Shin E. (2006)
    357. The relation between survival and expression of HER1 and HER2 depends on the expression of HER3 and HER4: a study in bladder cancer patients. (PubMed id 16685269)1, 9 Memon A.A....Nexo E. (2006)
    358. Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex. (PubMed id 15643424)1, 9 Xu W....Neckers L. (2005)
    359. The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells. (PubMed id 15461591)1, 9 Fauquette V....Van Seuningen I. (2005)
    360. Asp746 to glycine change may have a greater influence than Cys751 to serine change in accounting for ligand selectivity between EGFR and HER-2 at the ATP site. (PubMed id 16184431)1, 9 Kamath S.A. and Buolamwini J.K. (2005)
    361. Correlation of HER2 gene amplification with expression of the apoptosis-suppressing genes bcl-2 and bcl-x-L in ductal carcinoma in situ of the breast. (PubMed id 15722788)1, 9 Siziopikou K.P. and Khan S. (2005)
    362. c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent. (PubMed id 15585632)1, 9 Giatromanolaki A....Sivridis E. (2004)
    363. C-erb-B2 and Bcl-xl protein expression in Barrett's oesophagus in correlation with morphological parameters. (PubMed id 15638369)1, 9 Barwijuk-Machal/a M....Sobaniec-Lotowska M. (2004)
    364. Coamplified and overexpressed genes at ERBB2 locus in gastric cancer. (PubMed id 14991576)1, 9 Varis A....Knuutila S. (2004)
    365. Relation between HPV-DNA and expression of p53, bcl-2, p21WAF-1, MIB-1, HER-2/neu and DNA ploidy in early cervical carcinoma: correlation with clinical outcome. (PubMed id 15201979)1, 9 Graflund M....Karlsson M.G. (2004)
    366. Membranous levels of c-erbB-2 oncoprotein in gastric cancer: their relationship with clinicopathological parameters and their prognostic significance. (PubMed id 15646832)1, 9 Vizoso F.J....Allende M.T. (2004)
    367. HER-2 gene amplification correlates with higher levels of angiogenesis and lower levels of hypoxia in primary breast tumors. (PubMed id 15217943)1, 9 Blackwell K.L....Harris L.N. (2004)
    368. Prognostic significance of EGFR and Her-2 in oral cavity cancer in betel quid prevalent area cancer prognosis. (PubMed id 12915878)4, 9 Chen I.H....Cheng A.J. (2003)
    369. Different mechanisms are implicated in ERBB2 gene overexpression in breast and in other cancers. (PubMed id 12942124)1, 9 Vernimmen D....Winkler R. (2003)
    370. Expression of c-erbB-2 oncoprotein in different types of thyroid tumors: an immunohistochemical study. (PubMed id 14682475)1, 9 Gumurdulu D....Demircan O. (2003)
    371. Identification of patients with transitional cell carcinoma of the bladder overexpressing ErbB2, ErbB3, or specific ErbB4 isoforms: real-time reverse transcription-PCR analysis in estimation of ErbB receptor status from cancer patients. (PubMed id 14614020)1, 9 Junttila T.T....Elenius K. (2003)
    372. [Expression of nm23 and c-erbB-2 proteins in cells of primary colorectal cancer and its metastases] (PubMed id 14664140)1, 9 Delektorskaia V.V....Kushlinskii N.E. (2003)
    373. Paget's disease of the nipple: a copy number of the genes ERBB2 and CCND1 versus expression of the proteins ERBB-2 and cyclin D1. (PubMed id 14689059)1, 9 Mrhalova M. and Kodet R. (2003)
    374. Clinical value of p53, c-erbB-2, CEA and CA125 regarding relapse, metastasis and death in resectable non-small cell lung cancer. (PubMed id 14566828)1, 9 Pollan M....Rojas J.M. (2003)
    375. Differential regulation of components of the focal adhesion complex by heregulin: role of phosphatase SHP-2. (PubMed id 11807823)1, 9 Vadlamudi R.K....Kumar R. (2002)
    376. Marked intratumoral heterogeneity of c-myc and cyclinD1 but not of c-erbB2 amplification in breast cancer. (PubMed id 12379776)1, 9 Glockner S....Kreipe H. (2002)
    377. Treatment with HER-2 phosphorylation agonists enhance tumor ability to stimulate epitope specific CTL in vitro. (PubMed id 12168050)1, 9 Castilleja A....Ioannides C.G. (2002)
    378. Amplification of Her-2/neu gene in Her-2/neu-overexpressing and -nonexpressing breast carcinomas and their synchronous benign, premalignant, and metastatic lesions detected by FISH in archival material. (PubMed id 11850540)1, 9 Xu R....Feiner H. (2002)
    379. Episomally mediated overexpression of wild-type erbB-2 transforms MCF-10A breast epithelial cells. (PubMed id 12462379)1, 9 Yu B.W....Ramachandran S. (2002)
    380. Active signaling by HER-2/neu in a subpopulation of HER-2/neu-overexpressing ductal carcinoma in situ: clinicopathological correlates. (PubMed id 12438265)1, 9 DiGiovanna M.P....Stern D.F. (2002)
    381. ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions. (PubMed id 12143054)1, 9 Endo K....Sirica A.E. (2002)
    382. Anti-tumor activity of GW572016: a dual tyrosine kina se inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways. (PubMed id 12214266)7, 9 Xia W....Spector N.L. (2002)
    383. ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner. (PubMed id 11940572)1, 9 Ren Z. and Schaefer T.S. (2002)
    384. Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription. (PubMed id 11245482)1, 9 Bonvini P....Neckers L.M. (2001)
    385. ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases. (PubMed id 10358079)2, 9 Olayioye M.A....Hynes N.E. (1999)
    386. A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling. (PubMed id 10085134)1, 9 Wong L....Johnson G.R. (1999)
    387. Studies on the betacellulin receptor in pancreatic AR42J cells. (PubMed id 9662041)1, 9 Ishiyama N....Kojima I. (1998)
    388. p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2. (PubMed id 8617772)1, 9 Chavany C....Neckers L. (1996)
    389. Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas. (PubMed id 7538656)1, 9 Alimandi M....Kraus M.H. (1995)
    390. Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma. (PubMed id 1676673)1, 9 Peles E....Yarden Y. (1991)
    391. Diagnostic value of Her-2/neu, Cyfra 21-1, and carcin oembryonic antigen levels in malignant pleural effusions of lung adenocarcinoma . (PubMed id 20350214)1, 9 Huang W.W....Tseng C.E. (2010)
    392. Evaluation of tumor markers (HER-2/neu oncoprotein, C EA, and CA 15.3) in patients with locoregional breast cancer: prognostic value. (PubMed id 20361287)1, 9 Molina R....Velasco M. (2010)
    393. Detection and HER2 expression of circulating tumor ce lls: prospective monitoring in breast cancer patients treated in the neoadjuvan t GeparQuattro trial. (PubMed id 20406831)1, 9 Riethdorf S....Pantel K. (2010)
    394. Assessing HER2 gene amplification as a potential targ et for therapy in invasive urothelial bladder cancer with a standardized method ology: results in 1005 patients. (PubMed id 19889613)1, 9 LaAc M....Vieillefond A. (2010)
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    396. Interaction of syndecan and alpha6beta4 integrin cyto plasmic domains: regulation of ErbB2-mediated integrin activation. (PubMed id 20181947)1, 9 Wang H....Rapraeger A.C. (2010)
    397. Epidermal growth factor receptor and HER-2/neu status by immunohistochemistry and fluorescence in situ hybridization in adenocarcino mas of the biliary tree and gallbladder. (PubMed id 20040392)1, 9 Shafizadeh N....Kakar S. (2010)
    398. Steroid receptors, HER2/neu and Ki-67, in endometrioi d type of endometrial carcinoma: Correlation with conventional histomorphologic al features of prognosis. (PubMed id 19446313)1, 9 Chakravarty D....Dhaliwal L. (2010)
    399. Shc is required for ErbB2-induced inhibition of apopt osis but is dispensable for cell proliferation and disruption of cell polarity. (PubMed id 19826412)1, 9 Lucs A.V....Muthuswamy S.K. (2010)
    400. Expression of p53, c-erbB-2 and Ki67 in intestinal me taplasia and gastric carcinoma. (PubMed id 20082479)1, 9 Zheng Y....Zhang X.Y. (2010)
    401. Overexpression of Grb2/HER2 signaling in Chinese gast ric cancer: their relationship with clinicopathological parameters and prognost ic significance. (PubMed id 19337752)1, 9 Yu G.Z....Wang J.J. (2009)
    402. Serum tumor necrosis factor-alpha and interleukin-2 c oncentrations in newly diagnosed ERBB2 (HER2/neu) positive breast cancer patien ts. (PubMed id 19787624)1, 9 Saglam S....Gurdol F. (2009)
    403. HER-2/neu and topoisomerase-II-alpha expression and g enic amplification in pancreatic adenocarcinoma. (PubMed id 19582575)1, 9 Baiocchi G.L....Giulini S.M. (2009)
    404. Nuclear Y-box binding protein-1, a predictive marker of prognosis, is correlated with expression of HER2/ErbB2 and HER3/ErbB3 in non -small cell lung cancer. (PubMed id 19648825)1, 9 Kashihara M....Ono M. (2009)
    405. HER-2/neu expression in extramammary Paget disease: a clinicopathologic and immunohistochemistry study of 47 cases with and without underlying malignancy. (PubMed id 19519604)1, 9 Plaza J.A....Prieto V.G. (2009)
    406. Androgen receptor expression in prostate cancer cells is suppressed by activation of epidermal growth factor receptor and ErbB2. (PubMed id 19491261)1, 9 Cai C....Balk S.P. (2009)
    407. Involvement of the HER2 pathway in repair of DNA dama ge produced by chemotherapeutic agents. (PubMed id 19887555)1, 9 Boone J.J....Hochhauser D. (2009)
    408. HER2/neu (c-erbB-2) gene amplification and protein ex pression are rare in uterine cervical neoplasia: a tissue microarray study of 8 14 archival specimens. (PubMed id 19775342)1, 9 Lesnikova I....Koch J. (2009)
    409. Lack of elevated HER2/neu expression in epithelial dy splasia and oral squamous cell carcinoma in Iran. (PubMed id 19827890)1, 9 Seifi S....Ariaeifar B. (2009)
    410. Evaluation of gene amplification and protein expression of HER-2/neu in esophageal squamous cell carcinoma using Fluorescence in situ Hybridization (FISH) and immunohistochemistry. (PubMed id 19128465)1, 9 Sato-Kuwabara Y....Soares F.A. (2009)
    411. miR-331-3p regulates ERBB-2 expression and androgen r eceptor signaling in prostate cancer. (PubMed id 19584056)1, 9 Epis M.R....Leedman P.J. (2009)
    412. Aberrant expression of proteinase-activated receptor 4 promotes colon cancer cell proliferation through a persistent signaling that involves Src and ErbB-2 kinase. (PubMed id 19058300)1, 9 Gratio V....Darmoul D. (2009)
    413. Oncoprotein HCCR-1 expression in breast cancer is well correlated with known breast cancer prognostic factors including the HER2 overexpression, p53 mutation, and ER/PR status. (PubMed id 19208263)1, 9 Ha S.A....Kim J.W. (2009)
    414. Increased expression of ErbB-2 in liver is associated with hepatitis B x antigen and shorter survival in patients with liver cancer. (PubMed id 19610068)1, 9 Liu J....Feitelson M.A. (2009)
    415. Osteoblast-induced EGFR/ERBB2 signaling in androgen-sensitive prostate carcinoma cells characterized by multiplex kinase activity profiling. (PubMed id 19294521)1, 9 Bratland A....Ree A.H. (2009)
    416. Human epidermal growth factor receptor 2-positive bre ast cancer and central nervous system metastases. (PubMed id 19770385)1, 9 Leyland-Jones B. (2009)
    417. Status of HER1 and HER2 in peritoneal, ovarian and colorectal endometriosis and ovarian endometrioid adenocarcinoma. (PubMed id 19294416)1, 9 Uzan C....Vielh P. (2009)
    418. Lapatinib, a dual EGFR and HER2 tyrosine kinase inhib itor, downregulates thymidylate synthase by inhibiting the nuclear translocatio n of EGFR and HER2. (PubMed id 19529774)1, 9 Kim H.P....Kim T.Y. (2009)
    419. Androgen receptor controls EGFR and ERBB2 gene expression at different levels in prostate cancer cell lines. (PubMed id 19318561)1, 9 Pignon J.C....Winkler R. (2009)
    420. HER family receptor abnormalities in lung cancer brai n metastases and corresponding primary tumors. (PubMed id 19622585)1, 9 Sun M....Wistuba I.I. (2009)
    421. Even low-level HER2 expression may be associated with worse outcome in node-positive breast cancer. (PubMed id 19252432)1, 9 Gilcrease M.Z....Buchholz T.A. (2009)
    422. Changes over time of extracellular domain of HER2 (ECD/HER2) serum levels have prognostic value in metastatic breast cancer. (PubMed id 18437556)1, 9 Bramwell V.H....Chambers A.F. (2009)
    423. A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy. (PubMed id 18632642)1, 9 Lee-Hoeflich S.T....Stern H.M. (2008)
    424. Clinical pharmacology of trastuzumab. (PubMed id 18690878)7, 9 LevA-que D....Bergerat J.P. (2008)
    425. EGFR and erbB2 in malignant peripheral nerve sheath tumors and implications for targeted therapy. (PubMed id 18650488)1, 9 Holtkamp N....von Deimling A. (2008)
    426. Molecular markers (c-erbB-2, p53) in breast cancer. (PubMed id 19141397)1, 9 Agrawal A.K....Nienartowicz E. (2008)
    427. Prognostic significance of HER2 gene amplification according to stage of breast cancer. (PubMed id 18583876)1, 9 Kim Y.S....Park W.C. (2008)
    428. Prolyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stability. (PubMed id 19077306)1, 9 Lam P.B....Wulf G.M. (2008)
    429. Downregulation of HER2 by RIG1 involves the PI3K/Akt pathway in ovarian cancer cells. (PubMed id 18174256)1, 9 Ou C.C....Kao M.C. (2008)
    430. The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11. (PubMed id 18724389)1, 9 Chen C.... Seth A.K. (2008)
    431. Luteinizing hormone-induced up-regulation of ErbB-2 is insufficient stimulant of growth and invasion in ovarian cancer cells. (PubMed id 19010824)1, 9 Warrenfeltz S.W....Puett D. (2008)
    432. MUC4 interacts with ErbB2 in human gallbladder carcinoma: potential pathobiological implications. (PubMed id 18397823)1, 9 Miyahara N....Irimura T. (2008)
    433. Type 1 receptor tyrosine kinase profiles identify patients with enhanced benefit from anthracyclines in the BR9601 adjuvant breast cancer chemotherapy trial. (PubMed id 18768436)1, 9 Bartlett J.M....Twelves C.J. (2008)
    434. Prognostic value of expression of p53, proliferating cell nuclear antigen, and c-erbB-2 in laryngeal carcinoma. (PubMed id 18509272)1, 9 Micozkadioglu D....Cinel L. (2008)
    435. Construction of a fully retargeted herpes simplex virus 1 recombinant capable of entering cells solely via human epidermal growth factor receptor 2. (PubMed id 18684832)1, 9 Menotti L....Campadelli-Fiume G. (2008)
    436. A functionally significant cross-talk between androgen receptor and ErbB2 pathways in estrogen receptor negative breast cancer. (PubMed id 18516291)1, 9 Naderi A. and Hughes-Davies L. (2008)
    437. Cyclooxygenase-2 predicts adverse effects of tamoxifen: a possible mechanism of role for nuclear HER2 in breast cancer patients. (PubMed id 18469157)1, 9 Dillon M.F....Young L.S. (2008)
    438. Impact of insulin-like growth factor type 1 receptor, epidermal growth factor receptor, and HER2 expressions on outcomes of patients with gastric cancer. (PubMed id 18483367)1, 9 Matsubara J....Shimoda T. (2008)
    439. Her-2/neu amplification and breast cancer survival: results from the Shanghai breast cancer study. (PubMed id 18425397)1, 9 Beeghly-Fadiel A....Zheng W. (2008)
    440. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. (PubMed id 18408761)1, 9 Li D....Wong K.K. (2008)
    441. Lapatinib: a dual inhibitor of human epidermal growth factor receptor tyrosine kinases. (PubMed id 18803986)7, 9 Medina P.J. and Goodin S. (2008)
    442. HER-2/neu overexpression and amplification in uterine serous papillary carcinoma: comparative analysis of immunohistochemistry, real-time reverse transcription-polymerase chain reaction, and fluorescence in situ hybridization. (PubMed id 17451461)1, 9 Odicino F.E....Pecorelli S. (2008)
    443. Molecular characterisation of breast cancer patients at high and low recurrence risk. (PubMed id 18236071)1, 9 Bonin S....Stanta G. (2008)
    444. HER-2/neu expression is associated with high tumor cell proliferation and aggressive phenotype in a population based patient series of endometrial carcinomas. (PubMed id 18202752)1, 9 Engelsen I.B....Salvesen H.B. (2008)
    445. Serous carcinoma of the uterus-determination of HER-2/neu status using immunohistochemistry, chromogenic in situ hybridization, and quantitative polymerase chain reaction techniques: its significance and clinical correlation. (PubMed id 18248390)1, 9 Singh P....Davy M.L. (2008)
    446. MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells. (PubMed id 18381409)1, 9 Chaturvedi P....Batra S.K. (2008)
    447. Tubular carcinoma and grade 1 (well-differentiated) invasive ductal carcinoma: comparison of flat epithelial atypia and other intra-epithelial lesions. (PubMed id 18801081)1, 9 Kunju L.P....Kleer C.G. (2008)
    448. [Brain metastases in breast cancer: a special disease course for HER2 positive tumors] (PubMed id 19192581)1, 9 Hurkens K.P....Tjan-Heijnen V.C. (2008)
    449. EGFR, HER2, and HER3 expression in laryngeal primary tumors and corresponding metastases. (PubMed id 18172732)1, 9 Wei Q....Carlsson J. (2008)
    450. Could the truncated variant of ERBB2 be present in the squamous carcinomas of the cervix? (PubMed id 18818943)1, 9 Costa C....Alameda F. (2008)
    451. HER2 status of bone marrow micrometastasis and their corresponding primary tumours in a pilot study of 27 cases: a possible tool for anti-HER2 therapy management? (PubMed id 17262082)1, 9 Vincent-Salomon A....Sastre-Garau X. (2007)
    452. [Expressions and clinical significances of c-met, c-erbB-2, COX-2, and IL-6 in the biliary tract cancers] (PubMed id 18159174)1, 9 Joo H.H....Choi Y.K. (2007)
    453. Low HER2-expressing glioblastomas are more often secondary to anaplastic transformation of low-grade glioma. (PubMed id 17571214)1, 9 Mineo J.F....Dam Hieu P. (2007)
    454. Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer. (PubMed id 17440164)1, 9 Scaltriti M....Baselga J. (2007)
    455. Fhit expression protects against HER2-driven breast tumor development: unraveling the molecular interconnections. (PubMed id 17374991)1, 9 Bianchi F....Campiglio M. (2007)
    456. HER-2 gene amplification, serum nucleosomes, CEA and CA15.3 tumor markers in breast cancer patients. (PubMed id 20306655)1, 9 Zeiwar M.M....El Nagar M.R. (2007)
    457. Predominance of the basal type and HER-2/neu type in brain metastasis from breast cancer. (PubMed id 17541441)1, 9 Gaedcke J....Kreipe H.H. (2007)
    458. Clinical implications of HER-2/neu overexpression and proteolytic activity imbalance in breast cancer. (PubMed id 17613170)1, 9 Swellam M....Bushnak H.A. (2007)
    459. HER-2/neu expression in glioblastoma multiforme. (PubMed id 17536308)1, 9 Haynik D.M....Prayson R.A. (2007)
    460. Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells. (PubMed id 17631500)1, 9 Yoon S....Kim K.S. (2007)
    461. [Expression of c-erbB-2 and c-met proteins in gastric adenoma and adenocarcinoma] (PubMed id 18172343)1, 9 Lee S.W....Han S.W. (2007)
    462. HER-2 tissue expression correlated with serum levels in breast cancer patients. (PubMed id 17706017)1, 9 Pribylova O....Petruzelka L. (2007)
    463. Non-small cell lung carcinoma: cyclin D1, bcl-2, p53, Ki-67 and HER-2 proteins expression in resected tumors. (PubMed id 17848143)1, 9 Radovic S....Serdarevic F. (2007)
    464. p38MAPK-activated AKT in HER-2 overexpressing human breast cancer cells acts as an EGF-independent survival signal. (PubMed id 17612563)1, 9 Diehl K.M....Woods-Ignatoski K.M. (2007)
    465. HER2 expression as a potential marker for response to therapy targeted to the EGFR. (PubMed id 16622439)1, 9 Emlet D.R....Shackney S.E. (2006)
    466. Effects of HER2 overexpression on cell signaling networks governing proliferation and migration. (PubMed id 17016520)1, 9 Wolf-Yadlin A....White F.M. (2006)
    467. HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. (PubMed id 16843263)1, 9 Wang S.E....Arteaga C.L. (2006)
    468. Alterations of the CCND1 and HER-2/neu (ERBB2) proteins in esophageal and gastric cancers. (PubMed id 16490596)1, 9 Bizari L....Silva A.E. (2006)
    469. HER-2/neu gene amplification in ovarian tumours: a comprehensive immunohistochemical and FISH analysis on tissue microarrays. (PubMed id 16405663)1, 9 Mayr D....Diebold J. (2006)
    470. Over-expression of c-erbB-2 correlates with nuclear morphometry and prognosis in breast carcinoma in Asian women. (PubMed id 17393979)1, 9 Selvarajan S....Tan P.H. (2006)
    471. Allelic imbalance of HER2 variant in sporadic breast and ovarian cancer. (PubMed id 16682283)1, 9 Puputti M....Nupponen N.N. (2006)
    472. A novel mutation in the tyrosine kinase domain of ERBB2 in hepatocellular carcinoma. (PubMed id 17150109)1, 9 Bekaii-Saab T....Eng C. (2006)
    473. Yin Yang 1 cooperates with activator protein 2 to stimulate ERBB2 gene expression in mammary cancer cells. (PubMed id 15870067)1, 9 Begon D.Y....Winkler R. (2005)
    474. Integrin alpha6beta4-erbB2 complex inhibits haptotaxis by up-regulating E-cadherin cell-cell junctions in keratinocytes. (PubMed id 15579904)1, 9 Hintermann E....Quaranta V. (2005)
    475. Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis. (PubMed id 15609325)1, 9 Beckers J....Seliger B. (2005)
    476. Zinc finger transcription factors designed for bispecific coregulation of ErbB2 and ErbB3 receptors: insights into ErbB receptor biology. (PubMed id 16199884)1, 9 Lund C.V....Barbas C.F. (2005)
    477. Reorganization of ErbB family and cell survival signaling after Knock-down of ErbB2 in colon cancer cells. (PubMed id 15888451)1, 9 Hu Y.P....Brattain M.G. (2005)
    478. Biomarker analysis in carcinoma ex pleomorphic adenoma at an early phase of carcinomatous transformation. (PubMed id 16273189)1, 9 Freitas L.L....Altemani A. (2005)
    479. HER-2 gene amplification can be acquired as breast cancer progresses. (PubMed id 15194824)1, 9 Meng S....Uhr J. (2004)
    480. A unique structure for epidermal growth factor recept or bound to GW572016 (Lapatinib): relationships among protein conformation, inh ibitor off-rate, and receptor activity in tumor cells. (PubMed id 15374980)7, 9 Wood E.R....Shewchuk L. (2004)
    481. The ErbB2/Neu/HER2 receptor is a new calmodulin-binding protein. (PubMed id 15080792)1, 9 Li H....Villalobo A. (2004)
    482. HER-2/neu overexpression increases the viable hypoxic cell population within solid tumors without causing changes in tumor vascularization. (PubMed id 15561777)1, 9 Dragowska W.H....Bally M.B. (2004)
    483. Genetic and pathologic significance of 1p, 17p, and 18q aneusomy and the ERBB2 gene in colorectal cancer and related normal colonic mucosa. (PubMed id 15120910)1, 9 Cianciulli A....Guadagni F. (2004)
    484. Expression of c-erbB receptors, MMPs and VEGF in squamous cell carcinoma of the head and neck. (PubMed id 15254682)1, 9 Do N.Y....Im T.S. (2004)
    485. Clinical relevance of HER-2/neu expression in germ-cell testicular tumors. (PubMed id 15330164)1, 9 Mandoky L....Bak M. (2004)
    486. Emerging role of epidermal growth factor receptor inhibition in therapy for advanced malignancy: focus on NSCLC. (PubMed id 14967461)7, 9 Langer C.J. (2004)
    487. Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. (PubMed id 15235125)1, 9 Menendez J.A....Lupu R. (2004)
    488. Role of ErbB2 in Corneal Epithelial Wound Healing. (PubMed id 15557433)1, 9 Xu K.P....Yu F.S. (2004)
    489. E6/E7 proteins of HPV type 16 and ErbB-2 cooperate to induce neoplastic transformation of primary normal oral epithelial cells. (PubMed id 14724563)1, 9 Al Moustafa A.E....Alaoui-Jamali M.A. (2004)
    490. Cytoplasmic p21WAF1/CIP1 expression is correlated with HER-2/ neu in breast cancer and is an independent predictor of prognosis. (PubMed id 14580260)1, 9 Winters Z.E....Harris A.L. (2003)
    491. Quantitative association between HER-2/neu and steroid hormone receptors in hormone receptor-positive primary breast cancer. (PubMed id 12529347)1, 9 Konecny G....Slamon D.J. (2003)
    492. EGFR, HER-2/neu, cyclin D1, p21 and p53 in correlation to cell proliferation and steroid hormone receptor status in ductal carcinoma in situ of the breast. (PubMed id 12825853)1, 9 Lebeau A....Lohrs U. (2003)
    493. Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation. (PubMed id 12775708)1, 9 Martin L.A....Dowsett M. (2003)
    494. Identification of ErbB-2 kinase domain motifs required for geldanamycin-induced degradation. (PubMed id 12517775)1, 9 Tikhomirov O. and Carpenter G. (2003)
    495. The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation. (PubMed id 12853564)1, 9 Holbro T....Hynes N.E. (2003)
    496. ERBB2 up-regulates S100A4 and several other prometastatic genes in medulloblastoma. (PubMed id 12517790)1, 9 Hernan R....Gilbertson R.J. (2003)
    497. Prognostic role of apoptotic, Bcl-2, c-erbB-2 and p53 tumor markers in salivary gland malignancies. (PubMed id 12759537)1, 9 Nagler R.M....Ben-Itzhak O. (2003)
    498. HER2/neu overexpression in the development of muscle-invasive transitional cell carcinoma of the bladder. (PubMed id 14520464)1, 9 Latif Z....Bartlett J.M. (2003)
    499. Detection of urokinase plasminogen activator receptor and c-erbB-2 in sera of patients with breast and ovarian carcinoma. (PubMed id 14563447)1, 9 Mabrouk R.A. and Ali-Labib R. (2003)
    500. Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis. (PubMed id 12517789)1, 9 Kumar-Sinha C....Chinnaiyan A.M. (2003)
    501. Comparison of differential PCR and immunohistochemistry for the evaluation of c-erbB-2 in breast carcinoma and relationship to other prognostic factors. (PubMed id 14628084)1, 9 Erdogan S....Tuncer I. (2003)
    502. ErbB2 overexpression in an ovarian cancer cell line confers sensitivity to the HSP90 inhibitor geldanamycin. (PubMed id 12174876)1, 9 Smith V....Kelland L.R. (2002)
    503. [Expression and clinical significance of p53 and c-erbB2 in geriatric women with cervical carcinoma] (PubMed id 12451999)1, 9 Huang Y.W....Liu F.Y. (2002)
    504. The expression of c-erbB-1 and c-erbB-2 in Iranian patients with gastric carcinoma. (PubMed id 12579211)1, 9 Ghaderi A....Modjtahedi H. (2002)
    505. Bombesin antagonists inhibit growth of MDA-MB-435 estrogen-independent breast cancers and decrease the expression of the ErbB-2/HER-2 oncoprotein and c-jun and c-fos oncogenes. (PubMed id 11891317)1, 9 Bajo A.M....Szepeshazi K. (2002)
    506. Differential gene expression patterns in HER2/neu-positive and -negative breast cancer cell lines and tissues. (PubMed id 12368191)1, 9 Wilson K.S....Geradts J. (2002)
    507. HER2 overexpression in muscle-invasive urothelial carcinoma of the bladder: prognostic implications. (PubMed id 12432555)1, 9 Kruger S....Bohle A. (2002)
    508. Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu. (PubMed id 12239347)1, 9 Xu W....Neckers L. (2002)
    509. HER-2/neu evaluation by immunohistochemistry and fluorescence in situ hybridization in breast cancer: implications for daily laboratory practice. (PubMed id 12174949)1, 9 Larsimont D....Gancberg D. (2002)
    510. Overexpression of c-erbB-2 protein correlates with chromosomal gain at the c-erbB-2 locus and patient survival in advanced colorectal carcinomas. (PubMed id 12198768)1, 9 Knosel T....Petersen I. (2002)
    511. Evaluation of HER-2/neu gene amplification and protein expression in non-small cell lung carcinomas. (PubMed id 11986780)1, 9 Hirsch F.R....Bunn P.A. (2002)
    512. Characterization of the HER-2/neu oncogene by immunohistochemical and fluorescence in situ hybridization analysis in oral and oropharyngeal squamous cell carcinoma. (PubMed id 11839675)1, 9 Khan A.J....Haffty B.G. (2002)
    513. Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity. (PubMed id 10572067)1, 9 Fernandes A.M....Gerwin B.I. (1999)
    514. ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner. (PubMed id 9710588)1, 9 Olayioye M.A....Hynes N.E. (1998)
    515. Tyrosine phosphorylation of c-ErbB-2 is regulated by the cellular form of prostatic acid phosphatase in human prostate cancer cells. (PubMed id 9705354)1, 9 Meng T.C. and Lin M.F. (1998)
    516. Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells. (PubMed id 9590694)1, 9 Qiu Y....Kung H.J. (1998)
    517. ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. (PubMed id 9130710)1, 9 Graus-Porta D....Hynes N.E. (1997)
    518. Assignment of v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2) to human chromosome band 17q21.1 by in situ hybridization. (PubMed id 9154120)1, 9 Muleris M....Dutrillaux B. (1997)
    519. HER2 gene copy number status may influence clinical ef ficacy to anti-EGFR monoclonal antibodies in metastatic colorectal cancer patien ts. (PubMed id 23348520)1 Martin V....Cappuzzo F. (2013)
    520. Level of HER2/neu amplification in primary tumours and metastases in HER2-positive breast cancer and survival after trastuzumab therap y. (PubMed id 23473771)1 Gullo G....Santoro A. (2013)
    521. The receptor attachment function of measles virus hema gglutinin can be replaced with an autonomous protein that binds Her2/neu while m aintaining its fusion-helper function. (PubMed id 23536664)1 Rasbach A....Buchholz C.J. (2013)
    522. Evaluation of changes of biologic markers ER, PR, HER 2 and Ki-67 in breast cancer with administration of neoadjuvant dose-dense doxor ubicin, cyclophosphamide followed by paclitaxel. (PubMed id 23613389)1 Dede D.S....Ozisik Y. (2013)
    523. HER2 drives luminal breast cancer stem cells in the ab sence of HER2 amplification: implications for efficacy of adjuvant trastuzumab. (PubMed id 23442322)1 Ithimakin S....Wicha M.S. (2013)
    524. Non-small-cell lung cancer with HER2 exon 20 mutation: regression with dual HER2 inhibition and anti-VEGF combination treatment. (PubMed id 23328556)1 Falchook G.S....Kurzrock R. (2013)
    525. Junctional adhesion molecule-A is co-expressed with HE R2 in breast tumors and acts as a novel regulator of HER2 protein degradation an d signaling. (PubMed id 22751120)1 Brennan K....Hopkins A.M. (2013)
    526. Expression of Eag1 K+ channel and ErbBs in human pitui tary adenomas: cytoskeleton arrangement patterns in cultured cells. (PubMed id 23413122)1 del Pliego M.G....Mendoza-Garrido M.E. (2013)
    527. Her2 amplification distinguishes a subset of non-muscl e-invasive bladder cancers with a high risk of progression. (PubMed id 23087329)1 Chen P.C....Pan C.C. (2013)
    528. 'Omics' of HER2-positive breast cancer. (PubMed id 23421906)1 Bravata V....Minafra L. (2013)
    529. CDK inhibitor p57 (Kip2) is downregulated by Akt durin g HER2-mediated tumorigenicity. (PubMed id 23421998)1 Zhao R....Lee M.H. (2013)
    530. PTEN, Akt, MAPK, p53 and p95 expression to predict tra stuzumab resistance in HER2 positive breast cancer. (PubMed id 23613387)1 Duman B.B....Zorludemir S. (2013)
    531. Efficient downregulation of ErbB-2 induces TACC1 upreg ulation in breast cancer cell lines. (PubMed id 23354013)1 Xiang J....Yue L. (2013)
    532. HER2 expression and its clinicopathological features i n resectable gastric cancer. (PubMed id 22410801)1 Kataoka Y....Sakai Y. (2013)
    533. Clinical role of HER-2/neu expression in colorectal ca ncer. (PubMed id 23613394)1 Pappas A....Manouras A. (2013)
    534. The prognostic significance of p21 and Her-2 gene expr ession and mutation/polymorphism in patients with gastric adenocarcinoma. (PubMed id 23275116)1 Ozen A....Karagol H. (2013)
    535. Quantitative detection of HER2 protein concentration i n breast cancer tissue does not increase the number of patients eligible for adj uvant HER2-targeted therapy. (PubMed id 23417164)1 Bechmann T....Jakobsen A. (2013)
    536. Metformin inhibits proliferation and promotes apoptosi s of HER2 positive breast cancer cells by downregulating HSP90. (PubMed id 23613388)1 Chen T.W....Kong H. (2013)
    537. HER2 expression in Brazilian patients with estrogen an d progesterone receptor-negative breast carcinoma. (PubMed id 22647460)1 Ramalho Souza G. (2013)
    538. Autocrine motility factor promotes HER2 cleavage and s ignaling in breast cancer cells. (PubMed id 23248119)1 Kho D.H....Raz A. (2013)
    539. ErbB2-dependent chemotaxis requires microtubule captur e and stabilization coordinated by distinct signaling pathways. (PubMed id 23383112)1 Benseddik K....Badache A. (2013)
    540. Immunohistochemical expression of ErbB2 in adamantinom atous craniopharyngiomas: a possible target for immunotherapy. (PubMed id 23344868)1 Zuhur S.S....Altuntas Y. (2013)
    541. Comparison of fluorescence in situ hybridization (FISH ) and dual-ISH (DISH) in the determination of HER2 status in breast cancer. (PubMed id 23355198)1 Mansfield A.S....Jenkins R.B. (2013)
    542. Genetic alterations of K-ras, p53, c-erbB-2, and DPC4 in pancreatic ductal adenocarcinoma and their correlation with patient survival. (PubMed id 23344532)1 Shin S.H....Lee Y.J. (2013)
    543. HER2 Ile655Val and PTEN IVS4 polymorphisms in patients with breast cancer. (PubMed id 23086302)1 Ozturk O....Uras C. (2013)
    544. Serum HER-2: sensitivity, specificity, and predictive values for detecting metastatic recurrence in breast cancer patients. (PubMed id 23483255)1 Sorensen P.D....Brandslund I. (2013)
    545. Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis. (PubMed id 23592719)1 Laurin M....Cote J.F. (2013)
    546. Brk/PTK6 cooperates with HER2 and Src in regulating br east cancer cell survival and epithelial-to-mesenchymal transition. (PubMed id 23291984)1 Ai M....Fan Z. (2013)
    547. Constitutive HER2 signaling promotes breast cancer met astasis through cellular senescence. (PubMed id 23288917)1 Angelini P.D....Arribas J. (2013)
    548. Change in HER2 (ERBB2) gene status after taxane-based chemotherapy for breast cancer: polyploidization can lead to diagnostic pitfalls with potential impact for clinical management. (PubMed id 23313108)1 Valent A....Kroemer G. (2013)
    549. Adaptor protein complex of FRS2b and CIN85/CD2AP provi des a novel mechanism for ErbB2/HER2 protein downregulation. (PubMed id 23279575)1 Minegishi Y....Gotoh N. (2013)
    550. Clinical significance of intratumoral HER2 heterogenei ty in gastric cancer. (PubMed id 23146959)1 Lee H.E....Lee H.S. (2013)
    551. HER2 protein expression and HER2 gene amplification ar e infrequent in small intestinal carcinomas. (PubMed id 23703294)1 Gu M.J....Jung S.J. (2013)
    552. Negative transcriptional control of ERBB2 gene by MBP- 1 and HDAC1: diagnostic implications in breast cancer. (PubMed id 23421821)1 Contino F....Feo S. (2013)
    553. HER2 stabilizes survivin while concomitantly down-regu lating survivin gene transcription by suppressing Notch cleavage. (PubMed id 23323858)1 Ju J.H....Shin I. (2013)
    554. ErbB receptor tyrosine kinase family expression levels in urothelial bladder carcinoma. (PubMed id 23333248)1 Gunes S....Bagci H. (2013)
    555. Alcohol and HER2 polymorphisms as risk factor for card iotoxicity in breast cancer treated with trastuzumab. (PubMed id 23749910)1 Lemieux J....Laflamme C. (2013)
    556. Interaction between Her2 and Beclin-1 proteins underli es a new mechanism of reciprocal regulation. (PubMed id 23703612)1 Han J....Rabinowich H. (2013)
    557. Acquired substrate preference for GAB1 protein bestows transforming activity to ERBB2 kinase lung cancer mutants. (PubMed id 23612964)1 Fan Y.X....Johnson G.R. (2013)
    558. In situ analysis of HER2 mRNA in gastric carcinoma: co mparison with fluorescence in situ hybridization, dual-color silver in situ hybr idization, and immunohistochemistry. (PubMed id 23084583)1 Kim M.A....Kim W.H. (2013)
    559. Clinical usefulness of human epidermal growth factor r eceptor-2 extracellular domain as a biomarker for monitoring cancer status and p redicting the therapeutic efficacy in breast cancer. (PubMed id 23114645)1 Kontani K....Yokomise H. (2013)
    560. The HER2 status of disseminated tumor cells in the bon e marrow of early breast cancer patients is independent from primary tumor and p redicts higher risk of relapse. (PubMed id 23494674)1 Hartkopf A.D....Fehm T. (2013)
    561. The HSP90 inhibitor geldanamycin perturbs endosomal st ructure and drives recycling ErbB2 and transferrin to modified MVBs/lysosomal co mpartments. (PubMed id 23154999)1 Cortese K....Tacchetti C. (2013)
    562. Outcome impact of PIK3CA mutations in HER2-positive br east cancer patients treated with trastuzumab. (PubMed id 23612454)1 Cizkova M....Bieche I. (2013)
    563. WNT10B/b-catenin signalling induces HMGA2 and prolifer ation in metastatic triple-negative breast cancer. (PubMed id 23307470)1 Wend P....Miranda-Carboni G.A. (2013)
    564. RNA-based determination of ESR1 and HER2 expression an d response to neoadjuvant chemotherapy. (PubMed id 23131391)1 Denkert C....von Minckwitz G. (2013)
    565. Molecular characterization of mucinous ovarian tumours supports a stratified treatment approach with HER2 targeting in 19% of carcinom as. (PubMed id 22899400)1 Anglesio M.S....McAlpine J.N. (2013)
    566. Flotillins as regulators of ErbB2 levels in breast can cer. (PubMed id 22869152)1 Pust S....Sandvig K. (2013)
    567. HER2 mediates epidermal growth factor-induced down-reg ulation of E-cadherin in human ovarian cancer cells. (PubMed id 23542467)1 Cheng J.C....Leung P.C. (2013)
    568. Correlation of phosphorylated HER2 with clinicopatholo gical characteristics and efficacy of trastuzumab treatment for breast cancer. (PubMed id 23749902)1 Ramic S....Knezevic F. (2013)
    569. Racially restricted contribution of immunoglobulin Fcg and Fcg receptor genotypes to humoral immunity to human epidermal growth factor receptor 2 in breast cancer. (PubMed id 23379433)1 Pandey J.P....Tsugane S. (2013)
    570. Increased hyaluronan content and stromal cell CD44 ass ociate with HER2 positivity and poor prognosis in human breast cancer. (PubMed id 22753277)1 Auvinen P....Tammi M. (2013)
    571. Preubiquitinated chimeric ErbB2 is constitutively endo cytosed and subsequently degraded in lysosomes. (PubMed id 23127513)1 Vuong T.T....Madshus I.H. (2013)
    572. The detection of ESR1/PGR/ERBB2 mRNA levels by RT-QPCR : a better approach for subtyping breast cancer and predicting prognosis. (PubMed id 23397283)1 Du X....Feng Y.M. (2013)
    573. The predictive and prognostic significance of pre- and post-treatment topoisomerase IIa in anthracycline-based neoadjuvant chemotherap y for local advanced breast cancer. (PubMed id 23473851)1 Chen S....Shao Z.M. (2013)
    574. Reduction of the ST6 b-galactosamide a-2,6-sialyltrans ferase 1 (ST6GAL1)-catalyzed sialylation of nectin-like molecule 2/cell adhesion molecule 1 and enhancement of ErbB2/ErbB3 signaling by microRNA-199a. (PubMed id 23504322)1 Minami A....Takai Y. (2013)
    575. Plasma HER2 amplification in cell-free DNA during neoa djuvant chemotherapy in breast cancer. (PubMed id 23479212)1 Bechmann T....Jakobsen A. (2013)
    576. Discordant HER2 status between primary breast carcinom a and recurrent/metastatic tumors using fluorescence in situ hybridization on cy tological samples. (PubMed id 23225912)1 Arihiro K....Taira Y. (2013)
    577. A dominant-negative N-terminal fragment of HER2 freque ntly expressed in breast cancers. (PubMed id 22641219)1 Morancho B....Arribas J. (2013)
    578. HER2 and breast cancer stem cells: more than meets the eye. (PubMed id 23740771)1 Korkaya H. and Wicha M.S. (2013)
    579. Discrepancies between HER2 assessment from core needle biopsies and surgical specimens of invasive ductal breast carcinoma. (PubMed id 23468259)1 Wojnar A....Dziegiel P. (2013)
    580. Gamma-irradiation induces HER-2/neu overexpression in breast cancer cell lines and sensitivity to treatment with trastuzumab. (PubMed id 23311575)1 Voutsas I.F....Baxevanis C.N. (2013)
    581. Pak1 kinase links ErbB2 to b-catenin in transformation of breast epithelial cells. (PubMed id 23576562)1 Arias-Romero L.E....Chernoff J. (2013)
    582. EpCAM expression varies significantly and is different ially associated with prognosis in the luminal B HER2(+), basal-like, and HER2 i ntrinsic subtypes of breast cancer. (PubMed id 23519058)1 Soysal S.D....Gillanders W.E. (2013)
    583. Expression status of fatty acid synthase (FAS) but not HER2 is correlated with the differentiation grade and prognosis of esophageal c arcinoma. (PubMed id 23419663)1 Wu D....Wei Q. (2013)
    584. Is it necessary to evaluate nuclei in HER2 FISH evalua tion? (PubMed id 23270898)1 Lopez C....Lejeune M. (2013)
    585. Clinicopathologic characteristics of HER2 FISH-ambiguo us breast cancer at a single institution. (PubMed id 23108020)1 Clay M.R....Jensen K.C. (2013)
    586. Lung cancer that harbors an HER2 mutation: epidemiolog ic characteristics and therapeutic perspectives. (PubMed id 23610105)1 Mazieres J....Gautschi O. (2013)
    587. Validation of a new classifier for the automated analy sis of the human epidermal growth factor receptor 2 (HER2) gene amplification in breast cancer specimens. (PubMed id 23379971)1 Furrer D....Diorio C. (2013)
    588. Correlation analysis of c-myc, p21(WAF/CIP1), p53, C-e rbB-2 and COX-2 proteins in esophageal squamous cell carcinoma. (PubMed id 23177619)1 Gomes T.S....Ribeiro D.A. (2013)
    589. New targetable oncogenes in non-small-cell lung cancer . (PubMed id 23401445)1 Oxnard G.R....Janne P.A. (2013)
    590. Quantitation of sentinel node metastatic burden and He r-2/neu over-expression accurately predicts residual axillary nodal involvement and extranodal disease in breast cancer. (PubMed id 23523315)1 Chae A.W....Khatri V.P. (2013)
    591. Frequency of HER-2 positivity in rectal cancer and pro gnosis. (PubMed id 23282976)1 Conradi L.C....Liersch T. (2013)
    592. Activating HER2 mutations in HER2 gene amplification n egative breast cancer. (PubMed id 23220880)1 Bose R....Ellis M.J. (2013)
    593. 6 months versus 12 months of adjuvant trastuzumab for patients with HER2-positive early breast cancer (PHARE): a randomised phase 3 tr ial. (PubMed id 23764181)1 Pivot X....Kramar A. (2013)
    594. Clinical significance of nucleophosmin/B23 and human e pidermal growth factor receptor 2/neu expressions in gastric cancers. (PubMed id 23489260)1 Zhou F....Yue L. (2013)
    595. Prognostic significance of c-erbB2 overexpression in p atients with metastatic gastric cancer. (PubMed id 22911549)1 Bayrak M....Manavoglu O. (2013)
    596. Directed evolution of Her2/neu-binding IgG1-Fc for imp roved stability and resistance to aggregation by using yeast surface display. (PubMed id 23267121)1 Traxlmayr M.W....Obinger C. (2013)
    597. Early onset HER2-positive breast cancer is associated with germline TP53 mutations. (PubMed id 21761402)1 Melhem-Bertrandt A....Arun B.K. (2012)
    598. Protein interactions with HER-family receptors can hav e different characteristics depending on the hosting cell line. (PubMed id 22200885)1 Barta P....Andersson K. (2012)
    599. Simultaneous copy number gains of NUPR1 and ERBB2 pred icting poor prognosis in early-stage breast cancer. (PubMed id 22938721)1 Jung S.H....Chung Y.J. (2012)
    600. Reactive oxygen species regulate ERBB2 and ERBB3 expre ssion via miR-199a/125b and DNA methylation. (PubMed id 23146892)1 He J....Jiang B.H. (2012)
    601. NRF2 inhibition represses ErbB2 signaling in ovarian c arcinoma cells: implications for tumor growth retardation and docetaxel sensitiv ity. (PubMed id 22387177)1 Manandhar S....Kwak M.K. (2012)
    602. Expression levels of HER2/neu and those of collocated genes at 17q12-21, in breast cancer. (PubMed id 22552811)1 Glynn R.W....Kerin M.J. (2012)
    603. Intratumoral heterogeneity of HER2 gene amplification in breast cancer: its clinicopathological significance. (PubMed id 22388760)1 Seol H....Park S.Y. (2012)
    604. Seventeen-gene signature from enriched Her2/Neu mammar y tumor-initiating cells predicts clinical outcome for human HER2+:ERa- breast c ancer. (PubMed id 22460789)1 Liu J.C....Zacksenhaus E. (2012)
    605. A role of Rab7 in stabilizing EGFR-Her2 and in sustain ing Akt survival signal. (PubMed id 21928319)1 Wang T....Hong W. (2012)
    606. Polymorphism rs4919510:C>G in mature sequence of hu man microRNA-608 contributes to the risk of HER2-positive breast cancer but not other subtypes. (PubMed id 22586447)1 Huang A.J....Shao Z.M. (2012)
    607. HER2/neu expression in head and neck squamous cell car cinoma patients is not significantly elevated. (PubMed id 22938479)1 Sardari Y....Hamzavi M. (2012)
    608. Human epidermal growth factor receptor-2 gene amplific ation in gastric cancer using tissue microarray technology. (PubMed id 22253521)1 Tsapralis D....Karamitopoulou E. (2012)
    609. Leptin and HER-2 are associated with gastric cancer pr ogression and prognosis of patients. (PubMed id 22883999)1 Geng Y....Yin Y. (2012)
    610. Potential role of HER2-overexpressing exosomes in cou ntering trastuzumab-based therapy. (PubMed id 21465472)1 Ciravolo V....Pupa S.M. (2012)
    611. Prognostic significance of CD44 and c-erb-B2 protein o verexpression in patients with gastric cancer. (PubMed id 23435135)1 Doventas A....Doventas Y. (2012)
    612. Cross-talk between HER2 and MED1 regulates tamoxifen r esistance of human breast cancer cells. (PubMed id 22964581)1 Cui J....Zhang X. (2012)
    613. Trastuzumab combined with docetaxel-based regimens in previously treated metastatic gastric cancer patients with HER2 over-expression. (PubMed id 22534547)1 Dai G.H....Zhong M. (2012)
    614. Prognosis significance of HER-2/neu overexpression/amp lification in Chinese patients with curatively resected gastric cancer after the ToGA clinical trial. (PubMed id 23249720)1 Zhou F....Wang L. (2012)
    615. Cap-dependent mRNA translation and the ubiquitin-prote asome system cooperate to promote ERBB2-dependent esophageal cancer phenotype. (PubMed id 22767218)1 Issaenko O.A....Dahlberg P.S. (2012)
    616. HER2 status determination using RNA-ISH--a rapid and s imple technique showing high correlation with FISH and IHC in 141 cases of breas t cancer. (PubMed id 22763874)1 Alba J....Garcia-Caballero T. (2012)
    617. HER-2/neu overexpression is an independent prognostic factor for intestinal-type and early-stage gastric cancer patients. (PubMed id 22064554)1 Liu W....Yu Y. (2012)
    618. Factors influencing the hormone receptor and HER2 leve ls in breast cancer: a population-based analysis. (PubMed id 22414972)1 Tas F. (2012)
    619. HER-2/neu-mediated down-regulation of biglycan associa ted with altered growth properties. (PubMed id 22582394)1 Recktenwald C.V....Seliger B. (2012)
    620. Relationships between progesterone receptor isoforms a nd the HER/ErbB receptors and ligands network in 299 primary breast cancers. (PubMed id 22505232)1 Lindet C....Bonneterre J. (2012)
    621. HER2 expression in gastric and gastroesophageal juncti on adenocarcinoma in a US population: clinicopathologic analysis with proposed a pproach to HER2 assessment. (PubMed id 21617522)1 Kunz P.L....Pai R.K. (2012)
    622. Association of HER-2 copy number and HER-2/CEP-17 rati o with neoadjuvant taxane-containing chemotherapy sensitivity in locally advance d breast cancer. (PubMed id 22561335)1 Yu K.D....Shao Z.M. (2012)
    623. Gene expression profiles of phaeochromocytomas with ER BB2 overexpression reveal a new molecular mechanism tumourigenicity. (PubMed id 22429000)1 Qi Y....Ning G. (2012)
    624. A phase Ib study of preoperative lapatinib, paclitaxel , and gemcitabine combination therapy in women with HER2 positive early breast c ancer. (PubMed id 22006161)1 Park I.H....Ro J. (2012)
    625. A retrospective study investigating the rate of HER2 d iscordance between primary breast carcinoma and locoregional or metastatic disea se. (PubMed id 23176370)1 Chan A....Ingram D. (2012)
    626. Triple-negative phenotype is of adverse prognostic val ue in patients treated with dose-dense sequential adjuvant chemotherapy: a trans lational research analysis in the context of a Hellenic Cooperative Oncology Gro up (HeCOG) randomized phase III trial. (PubMed id 21901395)1 Skarlos P....Fountzilas G. (2012)
    627. Lapatinib plus capecitabine for brain metastases in pa tients with human epidermal growth factor receptor 2-positive advanced breast ca ncer: a review of the Anatolian Society of Medical Oncology (ASMO) experience. (PubMed id 23207619)1 Cetin B....Buyukberber S. (2012)
    628. Autophagy-related gene 12 (ATG12) is a novel determina nt of primary resistance to HER2-targeted therapies: utility of transcriptome an alysis of the autophagy interactome to guide breast cancer treatment. (PubMed id 23307622)1 Cufi S....Menendez J.A. (2012)
    629. Expression of EGFR, Her2 predict lymph node metastasis (LNM)-associated metastasis in colorectal cancer. (PubMed id 23220854)1 Lu Y....Cai S. (2012)
    630. HER2-negative (1+) breast cancer with unfavorable prog nostic features: to FISH or not to FISH? (PubMed id 22412042)1 Iorfida M....Colleoni M. (2012)
    631. Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasis. (PubMed id 22952421)1 Deng X....Yang X.H. (2012)
    632. Analysis of HER2 gene amplification and protein expres sion in esophageal squamous cell carcinoma. (PubMed id 21318736)1 Zhan N....Xiong C.L. (2012)
    633. [The search for protein overexpression and HER2 gene a mplification in gastric cancer by immunohistochemistry and in situ hybridization : experience of the CHU Hassan II of Fez]. (PubMed id 23397021)1 El Fatemi H....Mesbahi O. (2012)
    634. The EGF receptor and HER2 participate in TNF-a-depende nt MAPK activation and IL-8 secretion in intestinal epithelial cells. (PubMed id 22988345)1 Jijon H.B....Beck P.L. (2012)
    635. Coexpression of p53 and Ki 67 and lack of c-erbB2 expression in oral leukoplakias in India. (PubMed id 22641442)1 Kumar P....Rathod G.P. (2012)
    636. Frequency of driver mutations in lung adenocarcinoma f rom female never-smokers varies with histologic subtypes and age at diagnosis. (PubMed id 22317764)1 Zhang Y....Chen H. (2012)
    637. Trastuzumab-DM1: a clinical update of the novel antibo dy-drug conjugate for HER2-overexpressing breast cancer. (PubMed id 23196784)7 Barginear M.F....Budman D.R. (2012)
    638. Expression screening of 17q12-21 amplicon reveals GRB7 as an ERBB2-dependent oncogene. (PubMed id 22584052)1 Saito M....Watanabe S. (2012)
    639. A population-based study of Kurdish breast cancer in n orthern Iraq: hormone receptor and HER2 status. A comparison with Arabic women a nd United States SEER data. (PubMed id 22727195)1 Runnak M.A....Michael H.D. (2012)
    640. Expression of activated type I receptor tyrosine kinas es in early breast cancer. (PubMed id 22562124)1 Spears M....Bartlett J.M. (2012)
    641. ErbB2, EphrinB1, Src kinase and PTPN13 signaling compl ex regulates MAP kinase signaling in human cancers. (PubMed id 22279592)1 Vermeer P.D....Lee J.H. (2012)
    642. Charged linker sequence modulates eukaryotic heat shoc k protein 90 (Hsp90) chaperone activity. (PubMed id 22315411)1 Tsutsumi S....Neckers L.M. (2012)
    643. HER2 status in unusual histological variants of gastri c adenocarcinomas. (PubMed id 22067088)1 Giuffre G....Tuccari G. (2012)
    644. Sorafenib in combination with capecitabine: an oral re gimen for patients with HER2-negative locally advanced or metastatic breast canc er. (PubMed id 22412143)1 Baselga J....Costa F. (2012)
    645. Expression of HER2 and bradykinin B_1 receptors in pre cursor lesions of gallbladder carcinoma. (PubMed id 22468084)1 Toledo C....Poblete M.T. (2012)
    646. HER-2/neu gene amplification in carcinoma ex pleomorph ic adenoma in relation to progression and prognosis: a chromogenic in-situ hybri dization study. (PubMed id 22486195)1 Hashimoto K....Oda Y. (2012)
    647. Genetic heterogeneity of HER2 in breast cancer: impact on HER2 testing and its clinicopathologic significance. (PubMed id 22476857)1 Yang Y.L....Fu L. (2012)
    648. Activated HER-receptors in predicting outcome of ER-po sitive breast cancer patients treated with adjuvant endocrine therapy. (PubMed id 22854050)1 Larsen M.S....Rasmussen B.B. (2012)
    649. Chromogenic in situ hybridization (CISH) to detect HER 2 gene amplification in breast and gastric cancer: comparison with immunohistoch emistry (IHC) and fluorescence in situ hybridization (FISH). (PubMed id 23121603)1 Kiyose S....Sugimura H. (2012)
    650. Profiling signalling pathways in formalin-fixed and p araffin-embedded breast cancer tissues reveals cross-talk between EGFR, HER2, H ER3 and uPAR. (PubMed id 21391216)1 Berg D....Becker K.F. (2012)
    651. Correlation of HER2, p95HER2 and HER3 expression and t reatment outcome of lapatinib plus capecitabine in her2-positive metastatic brea st cancer. (PubMed id 22848366)1 Han S.W....Kim T.Y. (2012)
    652. Expression profiling during mammary epithelial cell th ree-dimensional morphogenesis identifies PTPRO as a novel regulator of morphogen esis and ErbB2-mediated transformation. (PubMed id 22851698)1 Yu M....Muthuswamy S.K. (2012)
    653. Down regulation of CD24 and HER-2/neu in breast carcin oma cells by activated human dendritic cell. Role of STAT3. (PubMed id 22480875)1 Hira S.K. and Manna P.P. (2012)
    654. MicroRNA-125b down-regulation mediates endometrial can cer invasion by targeting ERBB2. (PubMed id 22460089)1 Shang C....Meng L.R. (2012)
    655. Multiorgan metastasis of human HER-2+ breast cancer in Rag2-/-;Il2rg-/- mice and treatment with PI3K inhibitor. (PubMed id 22737248)1 Nanni P....Lollini P.L. (2012)
    656. PGC-1a promotes the growth of ErbB2/Neu-induced mammar y tumors by regulating nutrient supply. (PubMed id 22266114)1 Klimcakova E....St-Pierre J. (2012)
    657. Recycling of EGFR and ErbB2 is associated with impaire d Hrs tyrosine phosphorylation and decreased deubiquitination by AMSH. (PubMed id 22800866)1 Meijer I.M....van Leeuwen J.E. (2012)
    658. Intrinsic and acquired resistance to HER2-targeted the rapies in HER2 gene-amplified breast cancer: mechanisms and clinical implication s. (PubMed id 22471661)1 Rexer B.N. and Arteaga C.L. (2012)
    659. Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2. (PubMed id 22451678)1 Wang Y.N....Hung M.C. (2012)
    660. Negative/low HER2 expression alone or combined with E- cadherin positivity is predictive of better prognosis in patients with breast ca rcinoma. (PubMed id 22237715)1 Karray-Chouayekh S....Mokdad-Gargouri R. (2012)
    661. Comprehensive analysis of HER2 expression and gene amp lification in gastric cancers using immunohistochemistry and in situ hybridizati on: which scoring system should we use? (PubMed id 21855114)1 Park Y.S....Kang Y.K. (2012)
    662. Functional isolation of activated and unilaterally pho sphorylated heterodimers of ERBB2 and ERBB3 as scaffolds in ligand-dependent sig naling. (PubMed id 22733765)1 Zhang Q....Landgraf R. (2012)
    663. In situ detection of HER2:HER2 and HER2:HER3 protein-p rotein interactions demonstrates prognostic significance in early breast cancer. (PubMed id 21638049)1 Spears M....Bartlett J.M. (2012)
    664. Serum enterolactone and postmenopausal breast cancer r isk by estrogen, progesterone and herceptin 2 receptor status. (PubMed id 21544804)1 Zaineddin A.K....Chang-Claude J. (2012)
    665. Predictive value of HER2 serum levels in patients trea ted with lapatinib or trastuzumab -- a translational project in the neoadjuvant GeparQuinto trial. (PubMed id 22892393)1 Witzel I....Muller V. (2012)
    666. HER2/neu gene amplification and protein overexpression in gastric and gastroesophageal junction adenocarcinoma: a review of histopatho logy, diagnostic testing, and clinical implications. (PubMed id 22646280)1 Hechtman J.F. and Polydorides A.D. (2012)
    667. Impact of expression of human epidermal growth factor receptors EGFR and ERBB2 on survival in stage II/III gastric cancer. (PubMed id 22977193)1 Terashima M....Sasako M. (2012)
    668. An immunohistochemical study of HER2 expression in men ingioma and its correlation with tumor grade. (PubMed id 22420924)1 Mahzouni P. and Movahedipour M. (2012)
    669. The signaling and transformation potency of the overex pressed HER2 protein is dependent on the normally-expressed EGFR. (PubMed id 21911055)1 Zhou X. and Agazie Y.M. (2012)
    670. Phosphorylation of signal transducer and activator of transcription 3 (STAT3) correlates with Her-2 status, carbonic anhydrase 9 expre ssion and prognosis in esophageal cancer. (PubMed id 22484976)1 Schoppmann S.F....Birner P. (2012)
    671. Comparing of IRS and Her2 as immunohistochemical scori ng schemes in gastroenteropancreatic neuroendocrine tumors. (PubMed id 22558472)1 Kaemmerer D....Hommann M. (2012)
    672. L1CAM binds ErbB receptors through Ig-like domains cou pling cell adhesion and neuregulin signalling. (PubMed id 22815787)1 Donier E....Cabedo H. (2012)
    673. HER-2/neu gene amplification assessment in breast canc er patients in Isfahan province by real time PCR, differential PCR and immunohis tochemistry. (PubMed id 22326523)1 Hojati Z. and Orangi E. (2012)
    674. Expression and association of HER2 with prognosis in e arly-stage (T1-T2N0M0) non-small cell lung cancer. (PubMed id 22736332)1 Xia Q....Jang W. (2012)
    675. Discovery of novel 5-alkynyl-4-anilinopyrimidines as p otent, orally active dual inhibitors of EGFR and Her-2 tyrosine kinases. (PubMed id 22101132)1 Suzuki N....Wada T. (2012)
    676. Heterogeneity of ERBB2 amplification in adenocarcinoma , squamous cell carcinoma and large cell undifferentiated carcinoma of the lung. (PubMed id 22899293)1 Grob T.J....Wilczak W. (2012)
    677. Fluorescence in situ hybridization mapping of esophage ctomy specimens from patients with Barrett's esophagus with high-grade dysplasia or adenocarcinoma. (PubMed id 21820152)1 Brankley S.M....Halling K.C. (2012)
    678. Moderate immunohistochemical expression of HER-2 (2+) without HER-2 gene amplification is a negative prognostic factor in early breast cancer. (PubMed id 22951668)1 Rossi V....Montemurro F. (2012)
    679. Lung adenocarcinomas with HER2-activating mutations ar e associated with distinct clinical features and HER2/EGFR copy number gains. (PubMed id 22071781)1 Li C....Chen H. (2012)
    680. Efficacy and safety of neoadjuvant pertuzumab and tras tuzumab in women with locally advanced, inflammatory, or early HER2-positive bre ast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial. (PubMed id 22153890)1 Gianni L....Valagussa P. (2012)
    681. Her-2/neu assessment for gastric carcinoma: validation of scoring system. (PubMed id 22260838)1 Mrklic I....Tomic S. (2012)
    682. The relationship between the stromal mast cell number, microvessel density, c-erbB-2 staining and survival and prognostic factors in c olorectal carcinoma. (PubMed id 22627628)1 Elezoglu B. and Tolunay S. (2012)
    683. MEK inhibition leads to PI3K/AKT activation by relievi ng a negative feedback on ERBB receptors. (PubMed id 22552284)1 Turke A.B....Engelman J.A. (2012)
    684. Early HER2 dysregulation in gastric and oesophageal ca rcinogenesis. (PubMed id 22882541)1 Fassan M....Rugge M. (2012)
    685. Modeling invasive breast cancer: growth factors propel progression of HER2-positive premalignant lesions. (PubMed id 22139081)1 Pradeep C.R....Yarden Y. (2012)
    686. Clinical implications of pathophysiological and demogr aphic covariates on the population pharmacokinetics of trastuzumab emtansine, a HER2-targeted antibody-drug conjugate, in patients with HER2-positive metastatic breast cancer. (PubMed id 21953571)1 Gupta M....Girish S. (2012)
    687. ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression. (PubMed id 22464443)1 Rafn B....Kallunki T. (2012)
    688. Cross-regulation between FOXA1 and ErbB2 signaling in estrogen receptor-negative breast cancer. (PubMed id 22577344)1 Naderi A....Dowhan D.H. (2012)
    689. Decreased expression of C-erbB-2 and CXCR4 in breast c ancer after primary chemotherapy. (PubMed id 23046610)1 Yang S.X....Jiang J. (2012)
    690. Characterization of EGFR and ErbB2 expression in atopi c dermatitis patients. (PubMed id 22552355)1 Saaf A....Bradley M. (2012)
    691. Coordinated expression of oestrogen and androgen rece ptors in HER2-positive breast carcinomas: impact on proliferative activity. (PubMed id 22039288)1 Lin F.d.e. .M....Carvalho F.M. (2012)
    692. Prognostic role and HER2 expression of circulating tum or cells in peripheral blood of patients prior to radical cystectomy: a prospect ive study. (PubMed id 22277196)1 Rink M....Riethdorf S. (2012)
    693. Association of HER2/ErbB2 expression and gene amplific ation with pathologic features and prognosis in esophageal adenocarcinomas. (PubMed id 22252257)1 Yoon H.H....Sinicrope F.A. (2012)
    694. The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different si gnalling pathways. (PubMed id 22393391)1 Jonckheere N....Van Seuningen I. (2012)
    695. ERBB2 overexpression triggers transient high mechanoac tivity of breast tumor cells. (PubMed id 22407943)1 Martin M....Kas J.A. (2012)
    696. Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu. (PubMed id 22325357)1 De Greve J....Schallier D. (2012)
    697. PIK3CA mutations, PTEN, and pHER2 expression and impac t on outcome in HER2-positive early-stage breast cancer patients treated with ad juvant chemotherapy and trastuzumab. (PubMed id 22172323)1 Jensen J.D....Ewertz M. (2012)
    698. Observing the temperature dependent transition of the GP2 peptide using terahertz spectroscopy. (PubMed id 23209703)1 Sun Y....Pickwell-Macpherson E. (2012)
    699. Regulatory T cells increase in breast cancer and in st age IV breast cancer. (PubMed id 22116346)1 Wang Z.K....Jiao S.C. (2012)
    700. Immunohistochemical correlation of epidermal growth fa ctor receptor and c-erbB-2 with histopathologic grading of mucoepidermoid carcin oma. (PubMed id 23361279)1 Khiavi M.M....Halimi M. (2012)
    701. The interplay of HER2/HER3/PI3K and EGFR/HER2/PLC-g1 s ignalling in breast cancer cell migration and dissemination. (PubMed id 22262199)1 Balz L.M....Dittmar T. (2012)
    702. Increased concentrations of growth factors and activat ion of the EGFR system in breast cancer. (PubMed id 23089711)1 Olsen D.A....Brandslund I. (2012)
    703. The Na+/H+ exchanger NHE1, but not the Na+, HCO3(-) co transporter NBCn1, regulates motility of MCF7 breast cancer cells expressing con stitutively active ErbB2. (PubMed id 22120673)1 Lauritzen G....Pedersen S.F. (2012)
    704. HER-2 expression in immunohistochemistry has no progno stic significance in gastric cancer patients. (PubMed id 22645475)1 Halon A....Matkowski R. (2012)
    705. Efficacy of primed in situ labelling in determination of HER-2 gene amplification and CEN-17 status in breast cancer tissue. (PubMed id 22502695)1 Salimi M....Majidzadeh-A K. (2012)
    706. Prevalence, clinicopathologic associations, and molecu lar spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas. (PubMed id 22761469)1 Arcila M.E....Ladanyi M. (2012)
    707. Tumor necrosis factor a stimulates Her-2 cleavage by a ctivated caspase-8. (PubMed id 22922291)1 Li X....Ren H. (2012)
    708. A case of complete hydatidiform mole in a perimenopaus al woman with diagnostic usefulness of p57(kip2) immunohistochemistry and HER2 f luorescent in situ hybridization. (PubMed id 22197173)1 Hatanaka K....Tanimoto A. (2012)
    709. HER2 evaluation and its impact on breast cancer treatm ent decisions. (PubMed id 21540562)1 Goddard K.A....Wax C. (2012)
    710. HER2-associated radioresistance of breast cancer stem cells isolated from HER2-negative breast cancer cells. (PubMed id 23091114)1 Duru N....Li J.J. (2012)
    711. HER2/HER3 signaling regulates NK cell-mediated cytotox icity via MHC class I chain-related molecule A and B expression in human breast cancer cell lines. (PubMed id 22301547)1 Okita R....Kiessling R. (2012)
    712. Brain metastases in Asian HER2-positive breast cancer patients: anti-HER2 treatments and their impact on survival. (PubMed id 22918394)1 Yap Y.S....Ro J. (2012)
    713. Her2/neu small interfering RNA delivered in culture by a streptavidin nanoparticle. (PubMed id 22520071)1 Liu X....Hnatowich D.J. (2012)
    714. A-62176, a potent topoisomerase inhibitor, inhibits th e expression of human epidermal growth factor receptor 2. (PubMed id 22732416)1 Kim H.L....Kwon Y. (2012)
    715. Lack of independent prognostic and predictive value of centromere 17 copy number changes in breast cancer patients with known HER2 and TOP2A status. (PubMed id 22153616)1 Nielsen K.V....Mouridsen H.T. (2012)
    716. Modeling ductal carcinoma in situ: a HER2-Notch3 colla boration enables luminal filling. (PubMed id 21743488)1 Pradeep C.R....Yarden Y. (2012)
    717. Organotropism and prognostic marker discordance in dis tant metastases of breast carcinoma: fact or fiction? A clinicopathologic analys is. (PubMed id 21840040)1 St Romain P....Fan F. (2012)
    718. Primary human ovarian epithelial cancer cells broadly express HER2 at immunologically-detectable levels. (PubMed id 23189165)1 Lanitis E....Powell D.J. (2012)
    719. Model-based global sensitivity analysis as applied to identification of anti-cancer drug targets and biomarkers of drug resistance in the ErbB2/3 network. (PubMed id 22085636)1 Lebedeva G....Goryanin I. (2012)
    720. Polyclonal HER2-specific antibodies induced by vaccina tion mediate receptor internalization and degradation in tumor cells. (PubMed id 22676470)1 Ren X.R....Chen W. (2012)
    721. Involvement of CXCR4 chemokine receptor in metastastic HER2-positive esophageal cancer. (PubMed id 23082154)1 Gros S.J....Izbicki J.R. (2012)
    722. The atypical histone macroH2A1.2 interacts with HER-2 protein in cancer cells. (PubMed id 22589551)1 Li X....Kuwada S.K. (2012)
    723. A positive feedback loop between HER2 and ADAM12 in hu man head and neck cancer cells increases migration and invasion. (PubMed id 21986939)1 Rao V.H....Hansen L.A. (2012)
    724. MUC5AC, cytokeratin 20 and HER2 expression and K-RAS m utations within mucinogenic growth in congenital pulmonary airway malformations. (PubMed id 22348416)1 Rossi G....Rivasi F. (2012)
    725. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    726. Her-2/neu and topoisomerase IIa in advanced breast can cer: a comprehensive FISH analysis of 245 cases. (PubMed id 22555090)1 Engelstaedter V....Mayr D. (2012)
    727. C-Erb-b2 oncogene expression in intraductal proliferat ive lesions of the breast. (PubMed id 22364303)1 Eren F....Aydin O. (2012)
    728. Serum levels of epidermal growth factor, transforming growth factor, and c-erbB2 in ovarian cancer. (PubMed id 22914212)1 Balcan E....Cift T. (2012)
    729. Increased number of regulatory T cells (T-regs) in the peripheral blood of patients with Her-2/neu-positive early breast cancer. (PubMed id 22760213)1 Decker T....Gotze K. (2012)
    730. [Immunohistochemical study of adhesive molecules Her-2 /neu in nonendometrial carcinoma of corpus uteri]. (PubMed id 22712297)1 abdulaeva G.M....Gadzhieva S.M. (2012)
    731. Transcriptional regulation of the protocadherin b clus ter during Her-2 protein-induced mammary tumorigenesis results from altered N-gl ycan branching. (PubMed id 22665489)1 Guo H....Pierce M. (2012)
    732. Successful treatment of HER-2-positive metastatic apoc rine carcinoma of the skin with lapatinib and capecitabine. (PubMed id 22504780)1 Hidaka T....Aiba S. (2012)
    733. Assessment of human epidermal growth factor receptor 2 status in urothelial carcinoma of the upper urinary tract: a study using dual-c olor in situ hybridization and immunohistochemistry. (PubMed id 22495372)1 Vershasselt-Crinquette M....Leroy X. (2012)
    734. [Different Her-2 status in infiltrative and intraducta l components of the breast cancer]. (PubMed id 22880416)1 Povilaitite P.E....Petrov A.V. (2012)
    735. Association between growth factor heregulin1a and rece ptors in growth of ovarian cancer cell line with high potentiality of peritoneal dissemination. (PubMed id 22790889)1 Nishiyama H....Fujimori K. (2012)
    736. Expression of Wnt3 activates Wnt/b-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells. (PubMed id 23071104)1 Wu Y....Vadgama J.V. (2012)
    737. HER2 induces expression of leptin in human breast epit helial cells. (PubMed id 23261058)1 Cha Y....Moon A. (2012)
    738. Gene expression profiling identifies sST2 as an effect or of ErbB2-driven breast carcinoma cell motility, associated with metastasis. (PubMed id 22105364)1 Gillibert-Duplantier J....Badache A. (2012)
    739. HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-s ite EGFRT790M mutation. (PubMed id 22956644)1 Takezawa K....Pao W. (2012)
    740. HER2 and TOP2A in high-risk early breast cancer patien ts treated with adjuvant epirubicin-based dose-dense sequential chemotherapy. (PubMed id 22240029)1 Fountzilas G....Arapantoni P. (2012)
    741. Therapeutic strategies and mechanisms of tumorigenesis of HER2-overexpressing breast cancer. (PubMed id 20951604)1 Emde A....Yarden Y. (2012)
    742. EGFR overexpression relates to triple negative profile and poor prognosis in breast cancer patients in Tunisia. (PubMed id 22394363)1 Kallel I....Rebai A. (2012)
    743. Lymph node ratio: a new feature for defining risk cate gory of node-positive breast cancer patients. (PubMed id 22736300)1 Yang C....Fu L. (2012)
    744. Receptor tyrosine kinase ErbB2 translocates into mitoc hondria and regulates cellular metabolism. (PubMed id 23232401)1 Ding Y....Tan M. (2012)
    745. Human epidermal growth factor receptor 2 overexpressio n in breast cancer of patients with anti-Yo--associated paraneoplastic cerebella r degeneration. (PubMed id 22351748)1 Rojas-Marcos I....Graus F. (2012)
    746. Quantification of HER expression and dimerization in p atients' tumor samples using time-resolved Forster resonance energy transfer. (PubMed id 22829865)1 Ho-Pun-Cheung A....Lopez-Crapez E. (2012)
    747. MMP-9 increases HER2/neu expression and alters apoptos is levels in human mammary epithelial cells (HMEC). (PubMed id 22878890)1 Fatunmbi M....Aronica S.M. (2012)
    748. ErbB-2 signals through Plexin-B1 to promote breast can cer metastasis. (PubMed id 22378040)1 Worzfeld T....Offermanns S. (2012)
    749. Direct and immune mediated antibody targeting of ERBB receptors in a colorectal cancer cell-line panel. (PubMed id 23213241)1 Ashraf S.Q....Bodmer W.F. (2012)
    750. The hormone receptor, human epidermal growth factor r eceptor 2, and molecular subtype status of individual tumor foci in multifocal/ multicentric invasive ductal carcinoma of breast. (PubMed id 21733550)1 Choi Y....Park S.Y. (2012)
    751. MET activation mediates resistance to lapatinib inhibi tion of HER2-amplified gastric cancer cells. (PubMed id 22238368)1 Chen C.T....Weiser M.R. (2012)
    752. Comparison of two nomograms to predict pathologic comp lete responses to neoadjuvant chemotherapy for breast cancer: evidence that HER2 -positive tumors need specific predictors. (PubMed id 22160638)1 Frati A....Rouzier R. (2012)
    753. HER2/neu testing for anti-HER2-based therapies in pati ents with unresectable and/or metastatic gastric cancer. (PubMed id 22569536)1 Gomez-Martin C....Lopez-Rios F. (2012)
    754. Gene expression pattern of the epidermal growth factor receptor family and LRIG1 in renal cell carcinoma. (PubMed id 22554477)1 Thomasson M....Henriksson R. (2012)
    755. HER3 intracellular domains play a crucial role in HER3 /HER2 dimerization and activation of downstream signaling pathways. (PubMed id 22983903)1 Choi B.K....An Z. (2012)
    756. [Biological behaviour of colon cancer cells transfecte d with C-erbB2 shRNA plasmid]. (PubMed id 22482406)1 Zhao D.L....Sui Y.X. (2012)
    757. HER2/neu gene amplification heterogeneity: the signifi cance of cells with a 3:1 HER2/CEP17 ratio. (PubMed id 22495367)1 Layfield L.J. and Schmidt R.L. (2012)
    758. Human epidermal growth factor receptor 2 status and in terval breast cancer in a population-based cancer registry study. (PubMed id 22585698)1 Musolino A....Ardizzoni A. (2012)
    759. Establishment and characterization of a novel ovarian serous adenocarcinoma cell line, TU-OS-4, that overexpresses EGFR and HER2. (PubMed id 23274876)1 Itamochi H....Harada T. (2012)
    760. Hormone status and demographics in early onset breast cancer patients. (PubMed id 22748546)1 Friend K.E....Feliberti E.C. (2012)
    761. Is obesity always a risk factor for all breast cancer patients? c-erbB2 expression is significantly lower in obese patients with early stage breast cancer. (PubMed id 22855166)1 Mousa U....Utkan G. (2012)
    762. HER2 blockade in metastatic collecting duct carcinoma (CDC) of the kidney: a case report. (PubMed id 23207624)1 Bronchud M.H....Andreu X. (2012)
    763. Role of C-erbB2 expression in gallbladder cancer. (PubMed id 22499306)1 Kumari N....Baitha D.K. (2012)
    764. A gene-protein assay for human epidermal growth factor receptor 2 (HER2): brightfield tricolor visualization of HER2 protein, the HER2 gene, and chromosome 17 centromere (CEN17) in formalin-fixed, paraffin-embedded breast cancer tissue sections. (PubMed id 22647525)1 Nitta H....Grogan T.M. (2012)
    765. Epithelial-mesenchymal transition and stem cell marker s in patients with HER2-positive metastatic breast cancer. (PubMed id 22973057)1 Giordano A....Reuben J.M. (2012)
    766. A single ligand is sufficient to activate EGFR dimers. (PubMed id 22699492)1 Liu P....Leahy D.J. (2012)
    767. [HER-2/neu-testing in breast cancer: is the immunocyto chemistry competent?]. (PubMed id 22880415)1 Matsionis A.E....Povilaitite P.E. (2012)
    768. Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin-induced activatio n of ErbB3. (PubMed id 22248472)1 McDonagh C.F....Nielsen U.B. (2012)
    769. Comparison of four immunohistochemical tests and FISH for measuring HER2 expression in gastric carcinomas. (PubMed id 22437741)1 Cho E.Y....Kim S. (2012)
    770. The expression of PCNA, c-erbB-2, p53, ER and PR as we ll as atypical hyperplasia in tissues nearby the breast cancer. (PubMed id 22057681)1 Jia Z....Sheng W. (2012)
    771. Novel anti-HER2 monoclonal antibodies: synergy and ant agonism with tumor necrosis factor-a. (PubMed id 23033967)1 Ceran C....Yagci T. (2012)
    772. HER2 expression in breast cancer with nonamplified HER 2 and gains of chromosome 17 centromere. (PubMed id 22417858)1 Panvichian R....Leelaudomlipi S. (2012)
    773. ErbB2/Her-2 regulates the expression of Akt2 in prosta te cancer cells. (PubMed id 21932427)1 Le Page C....Mes-Masson A.M. (2012)
    774. Expression of epidermal growth factors, erbBs, in the nasal mucosa of patients with chronic hypertrophic rhinitis. (PubMed id 22327010)1 Nguyen K.H....Shibata M. (2012)
    775. HER2/neu and Ki-67 expression predict non-invasive rec urrence following breast-conserving therapy for ductal carcinoma in situ. (PubMed id 22361634)1 Rakovitch E....Paszat L. (2012)
    776. [Expression and significance of HER-2/neu mRNA and REC K mRNA in breast carcinoma tissue]. (PubMed id 23189844)1 Shen B....Feng J.F. (2012)
    777. Quantitation of HER2/neu expression in primary gastroe sophageal adenocarcinomas using conventional light microscopy and quantitative i mage analysis. (PubMed id 22646266)1 Jeung J....Liu C. (2012)
    778. Phase II trial of preoperative paclitaxel, gemcitabine , and trastuzumab combination therapy in HER2 positive stage II/III breast cance r: the Korean Cancer Study Group BR 07-01. (PubMed id 22094934)1 Im S.A....Ha S.W. (2012)
    779. HER-2/neu and TOPIIa expression in gastric cancer refl ect disease severity. (PubMed id 22281973)1 Liu H.Q....Song S. (2012)
    780. High serum HER2 extracellular domain levels: correlati on with a worse disease-free survival and overall survival in primary operable b reast cancer patients. (PubMed id 22116318)1 Kong Y....Xie X. (2012)
    781. ER, HER2, and TOP2A expression in primary tumor, synch ronous axillary nodes, and asynchronous metastases in breast cancer. (PubMed id 21667123)1 Jensen J.D....Laenkholm A.V. (2012)
    782. Target-specific, histology-independent, randomized dis continuation study of lapatinib in patients with HER2-amplified solid tumors. (PubMed id 20857170)1 Galsky M.D....Zaks T.Z. (2012)
    783. Her-2/neu gene amplification and over-expression in st omach and esophageal adenocarcinoma: from pathology to treatment. (PubMed id 21783379)1 Maresch J....Hejna M. (2012)
    784. Alterations in epidermal growth factor receptors 1 and 2 in esophageal squamous cell carcinomas. (PubMed id 23207070)1 Gonzaga I.M....Pinto L.F. (2012)
    785. EGFR, HER2, survivin, and loss of pSTAT3 characterize high-grade malignancy in salivary gland cancer with impact on prognosis. (PubMed id 22154363)1 Ettl T....Schwarz S. (2012)
    786. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    787. Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing. (PubMed id 21097718)2 Zang Z.J.... Tan P. (2011)
    788. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    789. IQGAP1 protein binds human epidermal growth factor re ceptor 2 (HER2) and modulates trastuzumab resistance. (PubMed id 21724847)1 White C.D....Sacks D.B. (2011)
    790. Molecular dynamics analysis of conserved hydrophobic and hydrophilic bond-interaction networks in ErbB family kinases. (PubMed id 21426301)1 Shih A.J....Radhakrishnan R. (2011)
    791. Function of erbB receptors and DNA-PKcs on phosphoryla tion of cytoplasmic and nuclear Akt at S473 induced by erbB1 ligand and ionizing radiation. (PubMed id 21723633)1 Toulany M....Rodemann H.P. (2011)
    792. Heterogeneous amplification of ERBB2 in primary lesion s is responsible for the discordant ERBB2 status of primary and metastatic lesio ns in gastric carcinoma. (PubMed id 22092393)1 Kim M.A....Kim W.H. (2011)
    793. Inactivation of Rac1 reduces Trastuzumab resistance i n PTEN deficient and insulin-like growth factor I receptor overexpressing human breast cancer SKBR3 cells. (PubMed id 21943825)1 Zhao Y....Yang C. (2011)
    794. Expression of activated HER2 in human testes. (PubMed id 21550039)1 Shin I....Park H.Y. (2011)
    795. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    796. HER2 overcomes PTEN (loss)-induced senescence to caus e aggressive prostate cancer. (PubMed id 21930937)1 Ahmad I....Leung H.Y. (2011)
    797. [Association of HER2 protein expression with clinicop athologic features and prognosis in Chinese patients with gastric carcinoma]. (PubMed id 21756821)1 Wu H.M....Lin X.T. (2011)
    798. HER2 and TOP2A as predictive markers for anthracyclin e-containing chemotherapy regimens as adjuvant treatment of breast cancer: a me ta-analysis of individual patient data. (PubMed id 21917518)1 Di Leo A....Buyse M. (2011)
    799. Human epidermal growth factor receptor 2 (HER2) in sa livary gland carcinomas. (PubMed id 21670724)1 Clauditz T.S....Wilczak W. (2011)
    800. Serum HER2/ECD value in stage I and II early breast ca ncer: need of a lower cut-off? (PubMed id 22113445)1 Badzek S....Mihaljevic Z. (2011)
    801. The ErbB3 binding protein EBP1 regulates ErbB2 protei n levels and tamoxifen sensitivity in breast cancer cells. (PubMed id 20379846)1 Lu Y....Hamburger A.W. (2011)
    802. EGFR, HER2 and HER3 expression in primary colorectal carcinomas and corresponding metastases: Implications for targeted radionuclide therapy. (PubMed id 21109951)1 Wei Q....Carlsson J. (2011)
    803. Simultaneous measurement of ERa, HER2, and phosphoERK1 /2 in breast cancer cell lines by flow cytometry. (PubMed id 21607585)1 Bayraktar U.D....Komanduri K.V. (2011)
    804. Evaluation of HER2 protein expression in gastric carc inomas: comparative analysis of 1,414 cases of whole-tissue sections and 595 ca ses of tissue microarrays. (PubMed id 21468783)1 Kim K.C....Park Y.S. (2011)
    805. ErbB2 down-regulates microRNA-205 in breast cancer. (PubMed id 21787752)1 Adachi R....Sakamaki T. (2011)
    806. Time-resolved fluorescence resonance energy transfer (TR-FRET) to analyze the disruption of EGFR/HER2 dimers: a new method to evalua te the efficiency of targeted therapy using monoclonal antibodies. (PubMed id 21282108)1 Gaborit N....PA"legrin A. (2011)
    807. Immunohistochemical detection of Her-2/neu overexpress ion in breast carcinoma in Nigerians: a 5-year retrospective study. (PubMed id 22037080)1 Ugiagbe E.E....Obaseki D.E. (2011)
    808. Detection of erbB2 copy number variations in plasma o f patients with esophageal carcinoma. (PubMed id 21481261)1 Andolfo I....Zollo M. (2011)
    809. Young age is associated with ipsilateral breast tumor recurrence after breast conserving surgery and radiation therapy in patients w ith HER2-positive/ER-negative subtype. (PubMed id 21853352)1 Kim H.J....Noh D.Y. (2011)
    810. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    811. Detection of HER2 amplification in circulating free D NA in patients with breast cancer. (PubMed id 21427727)1 Page K....Shaw J.A. (2011)
    812. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    813. A mathematical model for the effects of HER2 over-expression on cell cycle progression in breast cancer. (PubMed id 21814880)1 Eladdadi A. and Isaacson D. (2011)
    814. I^-catenin and Her2/neu expression in rectal cancer: a ssociation with histomorphological response to neoadjuvant therapy and prognosi s. (PubMed id 21538055)1 Drebber U....VallbAPhmer D. (2011)
    815. Many a mickle makes a muckle. Translating a gastric ca ncer phenotype into a bigger thing. (PubMed id 21985847)1 Blum M.A. and Ajani J.A. (2011)
    816. Survivin regulation by HER2 through NF-I_B and c-myc i n irradiated breast cancer cells. (PubMed id 20716114)1 Papanikolaou V....Tsezou A. (2011)
    817. Lactate dehydrogenase, Gleason score and HER-2 overex pression are significant prognostic factors for M1b prostate cancer. (PubMed id 21249322)1 Yamada Y....Honda N. (2011)
    818. Lipid-rich carcinoma of the breast clinicopathologic analysis of 17 cases. (PubMed id 21396871)1 Guan B....Zhou X. (2011)
    819. HER2 protein and gene variation between primary and m etastatic breast cancer: significance and impact on patient care. (PubMed id 21307144)1 Fabi A....Mottolese M. (2011)
    820. Comparison of hormonal receptor and HER-2 status betw een breast primary tumours and relapsing tumours: clinical implications of prog esterone receptor loss. (PubMed id 21643691)1 Bogina G....Zamboni G. (2011)
    821. Protein secretion in human mammary epithelial cells f ollowing HER1 receptor activation: influence of HER2 and HER3 expression. (PubMed id 21320340)1 Zhang Y....Zangar R.C. (2011)
    822. Assessment of ErbB2 (Her2) in oesophageal adenocarcin omas: summary of a revised immunohistochemical evaluation system, bright field double in situ hybridisation and fluorescence in situ hybridisation. (PubMed id 21516080)1 Langer R....Walch A. (2011)
    823. Truncated ErbB2 expressed in tumor cell nuclei contri butes to acquired therapeutic resistance to ErbB2 kinase inhibitors. (PubMed id 21673090)1 Xia W....Spector N.L. (2011)
    824. Her2 amplification is significantly more frequent in lymph node metastases from urothelial bladder cancer than in the primary tumour s. (PubMed id 21640482)1 Fleischmann A....Thalmann G.N. (2011)
    825. Significance of epidermal growth factor receptor expre ssion in breast cancer. (PubMed id 21104342)1 Badovinac-Crnjevic T....Vrbanec D. (2011)
    826. RIBBON-1: randomized, double-blind, placebo-controlle d, phase III trial of chemotherapy with or without bevacizumab for first-line t reatment of human epidermal growth factor receptor 2-negative, locally recurren t or metastatic breast cancer. (PubMed id 21383283)1 Robert N.J....O'Shaughnessy J. (2011)
    827. Multiple cancer/testis antigens are preferentially ex pressed in hormone-receptor negative and high-grade breast cancers. (PubMed id 21437249)1 Chen Y.T....Neville A.M. (2011)
    828. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    829. HER2-positive circulating tumor cells in breast cance r. (PubMed id 21264346)1 Ignatiadis M....Sotiriou C. (2011)
    830. ADAM 10 is associated with gastric cancer progression and prognosis of patients. (PubMed id 21259244)1 Wang Y.Y....Tao H.Q. (2011)
    831. Tumor escape and progression of HER-2/neu negative br east cancer under immune pressure. (PubMed id 21453513)1 Kmieciak M....Manjili M.H. (2011)
    832. Involvement of HER-2/neu and metastasis-related prote ins in the development of ileal neuroendocrine tumors. (PubMed id 21445634)1 Azzoni C....Bordi C. (2011)
    833. Genetic alterations and protein expression of HER2 an d chromosome 17 polysomy in breast cancer. (PubMed id 21676436)1 Zhu X....Zhou X. (2011)
    834. [Correlation of expression of Survivin, BCRP and HER-2 genes with therapeutic response of TE regimen neoadjuvant chemotherapy in breas t cancer patients]. (PubMed id 22340101)1 Li X....Hu X. (2011)
    835. Expression and clinical significance of leptin, the f unctional receptor of leptin (OB-Rb) and HER-2 in non-small-cell lung cancer: a retrospective analysis. (PubMed id 21927908)1 Xu Y.J....Yin Y.M. (2011)
    836. Clinical outcome of adjuvant endocrine treatment acco rding to Her-2/neu status in breast cancer. (PubMed id 21321422)1 James R....Ramaswamy G. (2011)
    837. p130Cas promotes invasiveness of three-dimensional Er bB2-transformed mammary acinar structures by enhanced activation of mTOR/p70S6K and Rac1. (PubMed id 20961652)1 Tornillo G....Cabodi S. (2011)
    838. Thrombospondin-1 opens the paracellular pathway in pu lmonary microvascular endothelia through EGFR/ErbB2 activation. (PubMed id 21531776)1 Garg P....Goldblum S.E. (2011)
    839. Different HER2 protein expression profiles aid in the histologic differential diagnosis between urothelial carcinoma in situ (CIS) a nd non-CIS conditions (dysplasia and reactive atypia) of the urinary bladder mu cosa. (PubMed id 22095373)1 Gunia S....Erbersdobler A. (2011)
    840. Hunk is required for HER2/neu-induced mammary tumorig enesis. (PubMed id 21393859)1 Yeh E.S....Chodosh L.A. (2011)
    841. Presence of Foxp3 expression in tumor cells predicts better survival in HER2-overexpressing breast cancer patients treated with neoa djuvant chemotherapy. (PubMed id 20229175)1 Ladoire S....Ghiringhelli F. (2011)
    842. [Expression of human epidermal growth factor receptor 2 in gastroesophageal cancer with different scoring systems and its relationship with clinicopathological features]. (PubMed id 21614691)1 Ji X....Ji J.F. (2011)
    843. Phase II study of the antibody drug conjugate trastuz umab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-p ositive breast cancer after prior HER2-directed therapy. (PubMed id 21172893)1 Burris H.A....O'Shaughnessy J.A. (2011)
    844. Expression patterns of ER, HER2, and NM23-H1 in breas t cancer patients with different menopausal status: correlations with metastasi s. (PubMed id 21913743)1 Dong S.W....Song X. (2011)
    845. Assessing the impact of polysomy-17 on HER2 status an d the correlations of HER2 status with prognostic variables (ER, PR, p53, Ki-67 ) in epithelial ovarian cancer: a tissue microarray study using immunohistochem istry and fluorescent in situ hybridization. (PubMed id 21623202)1 Lin C.K....Han C.P. (2011)
    846. High serum TGF-I+ predicts poor response to lapatinib and capecitabine in HER2-positive breast cancer. (PubMed id 20936340)1 Rhee J....Kim T.Y. (2011)
    847. Clinicopathologic significance of HER-2/neu protein e xpression and gene amplification in gastric carcinoma. (PubMed id 21472111)1 Yan S.Y....Du Y.Q. (2011)
    848. Lack of association between HER2 codon 655 polymorphi sm and breast cancer susceptibility was not credible: appraisal of a recent met a-analysis. (PubMed id 20882402)1 Lu P.H. and Huang X.F. (2011)
    849. Estrogen receptor positive operable breast cancer: doe s menopausal status impact on HER2 and progesterone receptor status? (PubMed id 21700456)1 Wang N....Hu J. (2011)
    850. Prognostic and predictive implications of HER2/ERBB2/ neu gene mutations in lung cancers. (PubMed id 21353324)1 Tomizawa K....Mitsudomi T. (2011)
    851. Prognostic implications of altered human epidermal gr owth factor receptors (HERs) in gastric carcinomas: HER2 and HER3 are predictor s of poor outcome. (PubMed id 21709195)1 Begnami M.D....Soares F.A. (2011)
    852. Her-2/neu gene amplification in esophageal adenocarci noma and its influence on survival. (PubMed id 21267790)1 Thompson S.K....Ruszkiewicz A.R. (2011)
    853. Influence of affinity and antigen internalization on the uptake and penetration of Anti-HER2 antibodies in solid tumors. (PubMed id 21406401)1 Rudnick S.I....Adams G.P. (2011)
    854. Growth differentiation factor 15 (GDF15)-mediated HER 2 phosphorylation reduces trastuzumab sensitivity of HER2-overexpressing breast cancer cells. (PubMed id 21803025)1 Joshi J.P....Nahta R. (2011)
    855. Antisense oligodeoxynucleotide targeting HER2 mRNA sen sitized docetaxel in breast cancer treatment. (PubMed id 22014264)1 Sun J....Duan H. (2011)
    856. Tid1, CHIP and ErbB2 interactions and their prognosti c implications for breast cancer patients. (PubMed id 21710689)1 Jan C.I....Lo J.F. (2011)
    857. c-erbB-2 protein expression in astrocytic tumors of t he brain. (PubMed id 21804458)1 ReszeA8 J....Mariak Z. (2011)
    858. TOP2A amplification in the absence of that of HER-2/n eu: toward individualization of chemotherapeutic practice in breast cancer. (PubMed id 21705665)1 Glynn R.W....Kerin M.J. (2011)
    859. HER2 gene amplification in patients with breast cance r with equivocal IHC results. (PubMed id 21836036)1 Meijer S.L....van de Vijver M.J. (2011)
    860. HER-2 protein overexpressing breast cancer without ge ne amplification shows higher hormone receptor expression than HER-2 protein ov erexpressing breast cancer with gene amplification. (PubMed id 19666946)1 Koo J.S....Yang W.I. (2011)
    861. Heterogeneous HER2 gene amplification: impact on pati ent outcome and a clinically relevant definition. (PubMed id 21757600)1 Bartlett A.I....Bartlett J.M. (2011)
    862. Observer prediction of HER2 amplification in HercepTe st 2+ breast cancers as a potential audit instrument. (PubMed id 21884213)1 Going J.J. (2011)
    863. HER2/ErbB2 receptor signaling in rat and human prolac tinoma cells: strategy for targeted prolactinoma therapy. (PubMed id 21106881)1 Fukuoka H....Melmed S. (2011)
    864. Eosinophil peroxidase signals via epidermal growth fa ctor-2 to induce cell proliferation. (PubMed id 21454806)1 Walsh M.T....Costello R.W. (2011)
    865. P16, c-erbB2 and Ki67 immunoexpression in urothelial carcinomas of the bladder. (PubMed id 21655657)1 Stepan A....Ciurea R. (2011)
    866. The prognostic significance of HER2 overexpression in non-small cell lung cancer. (PubMed id 22199341)1 Takenaka M....Tanaka F. (2011)
    867. Carbamazepine promotes Her-2 protein degradation in b reast cancer cells by modulating HDAC6 activity and acetylation of Hsp90. (PubMed id 21082217)1 Meng Q....Cai L. (2011)
    868. Glycoengineered Pichia produced anti-HER2 is comparab le to trastuzumab in preclinical study. (PubMed id 21487242)1 Zhang N....Zha D. (2011)
    869. Determination of her-2/neu by chromogenic in situ hybr idization on borderline (2+) immunohistochemistry cases in carcinoma breast. (PubMed id 21517259)1 Asif M....Ali Z. (2011)
    870. Overexpression of c-erbB-2 and loss of p16 have molec ular diagnostic relevance but no prognostic value in lung cancer. (PubMed id 20237870)1 Feng X.L....Cheng S.J. (2011)
    871. HER-2/neu gene codon 655 (Ile/Val) polymorphism in br east carcinoma patients. (PubMed id 21204706)1 Sezgin E....Demirhan B. (2011)
    872. Tyrosine phosphatases in the HER2-directed motility o f ovarian cancer cells: Involvement of PTPN12, ERK5 and FAK. (PubMed id 21483099)1 Villa-Moruzzi E. (2011)
    873. HER2 status in operable breast cancers from Vietnames e women: Analysis by immunohistochemistry (IHC) and automated silver enhanced i n situ hybridization (SISH). (PubMed id 21338271)1 Thang V.H....Skoog L. (2011)
    874. Positive response to trastuzumab in a case of HER2-ove rexpressing metastatic gastric cancer that presented as severe thrombocytopenia. (PubMed id 22104159)1 Choi J.H....Kim S.T. (2011)
    875. Human epidermal growth factor receptor 2 (HER2/neu) su praexpression in the mammary tumors. (PubMed id 22119832)1 Moise M....Niculescu M. (2011)
    876. HER2 genetic heterogeneity in breast carcinoma. (PubMed id 22011446)1 Ohlschlegel C....Jochum W. (2011)
    877. The I^2-adrenergic receptor and Her2 comprise a positi ve feedback loop in human breast cancer cells. (PubMed id 20237834)1 Shi M....Guo N. (2011)
    878. Immunohistochemical COX-2 overexpression correlates w ith HER-2/neu overexpression in invasive breast carcinomas: a pilot study. (PubMed id 21371829)1 A8iriA9 I.M....KapucuoA9lu F.N. (2011)
    879. [Correlation of CerbB-2 to Ki-67 and P53 expressions in hormone-independent breast cancer]. (PubMed id 21354936)1 Fang Q. and Wang X.F. (2011)
    880. A different immunologic profile characterizes patients with HER-2-overexpressing and HER-2-negative locally advanced breast cancer: im plications for immune-based therapies. (PubMed id 22112244)1 Muraro E....Dolcetti R. (2011)
    881. T cell recognition of HLA-A2 restricted tumor antigen s is impaired by the oncogene HER2. (PubMed id 20715101)1 Mimura K....Kiessling R. (2011)
    882. Astrocyte elevated gene-1 induces breast cancer prolif eration and invasion through upregulating HER2/neu expression. (PubMed id 22340175)1 Zhang X....Zhang M.X. (2011)
    883. Preclinical screening of anti-HER2 nanobodies for mol ecular imaging of breast cancer. (PubMed id 21478264)1 Vaneycken I....Caveliers V. (2011)
    884. Prognostic significance of HER2/neu expression in gast ric cancer. (PubMed id 21739203)1 Ananiev J....Tchernev G. (2011)
    885. Target therapy in HER2-overexpressing breast cancer p atients. (PubMed id 21568729)1 Amodio R....Romano N. (2011)
    886. Expression and significance of HER family receptors i n neuroblastic tumors. (PubMed id 21203803)1 Izycka-Swieszewska E....Limon J. (2011)
    887. Calmodulin binds HER2 and modulates HER2 signaling. (PubMed id 21185879)1 White C.D....Sacks D.B. (2011)
    888. YB-1 evokes susceptibility to cancer through cytokine sis failure, mitotic dysfunction and HER2 amplification. (PubMed id 21423216)1 Davies A.H....Dunn S.E. (2011)
    889. Trastuzumab plus chemotherapy in gastric cancer overe xpressing HER-2 and EGFR: a case report. (PubMed id 21346384)1 Al-Batran S.E....JAoger E. (2011)
    890. ERBB2 gene amplification in oral squamous cell malign ancies: a correlation with tumor progression and gene expression. (PubMed id 21531597)1 Chu F....Shen G. (2011)
    891. Familial and sporadic breast cancers: differences in c linical, histopathological, and immunohistochemical features. (PubMed id 20308044)1 D'Eredita' G....Berardi T. (2011)
    892. The human splice variant I916HER2 induces rapid tumor onset in a reporter transgenic mouse. (PubMed id 21559085)1 Marchini C....Amici A. (2011)
    893. SLP-2 overexpression could serve as a prognostic facto r in node positive and HER2 negative breast cancer. (PubMed id 22081131)1 Cao W....Sun B. (2011)
    894. Expression of survivin, CD117, and C-erbB-2 in neuroe ndocrine carcinoma of the uterine cervix. (PubMed id 21633298)1 Sukpan K....Siriaunkgul S. (2011)
    895. Reduced dose and intermittent treatment with lapatini b and trastuzumab for potent blockade of the HER pathway in HER2/neu-overexpres sing breast tumor xenografts. (PubMed id 21138857)1 Rimawi M.F....Schiff R. (2011)
    896. Poly (A)+ transcriptome assessment of ERBB2-induced a lterations in breast cell lines. (PubMed id 21731642)1 Carraro D.M....Brentani R.R. (2011)
    897. A UK NEQAS ISH multicenter ring study using the Venta na HER2 dual-color ISH assay. (PubMed id 21173138)1 Bartlett J.M....Miller K. (2011)
    898. Distinct distribution and prognostic significance of molecular subtypes of breast cancer in Chinese women: a population-based cohort study. (PubMed id 21749714)1 Su Y....Shu X.O. (2011)
    899. Ubiquitination and downregulation of ErbB2 and estrog en receptor-alpha by kinase inhibitor MP-412 in human breast cancer cells. (PubMed id 21503962)1 Suzuki T....Nakamura H. (2011)
    900. Correlation of HER 2/neu gene amplification with immu nohistochemistry and other prognostic factors in breast carcinoma. (PubMed id 21935868)1 Ramadan S.S....CakmakAsi M. (2011)
    901. [Evaluation of HER2 protein overexpression in non-mus cle-invasive bladder cancer with emphasis on tumour grade and recurrence]. (PubMed id 21419519)1 Janane A....Bouzidi A. (2011)
    902. Polymalic acid-based nanobiopolymer provides efficien t systemic breast cancer treatment by inhibiting both HER2/neu receptor synthes is and activity. (PubMed id 21303974)1 Inoue S....Ljubimova J.Y. (2011)
    903. p185, an immunodominant epitope, is an autoantigen mi motope. (PubMed id 21566138)1 Kumar S....Isenberg D.A. (2011)
    904. Alternative HER/PTEN/Akt pathway activation in HPV po sitive and negative penile carcinomas. (PubMed id 21407808)1 Stankiewicz E....Berney D.M. (2011)
    905. Clinicopathological and prognostic significance of HE R-2/neu and VEGF expression in colon carcinomas. (PubMed id 21708009)1 Li Q....Chen P. (2011)
    906. A positive cross-regulation of HER2 and ER-I+36 contro ls ALDH1 positive breast cancer cells. (PubMed id 21907803)1 Kang L....Wang Z.Y. (2011)
    907. [Expression of HER-2 and leptin in gastric cancer and their clinical significance]. (PubMed id 22335909)1 Geng Y.T....Yin Y.M. (2011)
    908. Overexpressed HER2 in NSCLC is a possible therapeutic target of EGFR inhibitors. (PubMed id 22199274)1 Ise N....Goishi K. (2011)
    909. Relation between transforming growth factor-b1 express ion, its receptor and clinicopathological factors and survival in HER2-negative gastric cancers. (PubMed id 22015652)1 Ananiev J....Manolova I. (2011)
    910. Bacterial cytoplasm production of an EGFP-labeled sing le-chain Fv antibody specific for the HER2 human receptor. (PubMed id 22066531)1 Lombardi A....Sperandei M. (2011)
    911. Her2 amplification status in Iranian breast cancer pat ients: comparison of immunohistochemistry (IHC) and fluorescence in situ hybridi sation (FISH). (PubMed id 21790246)1 Ghaffari S.R....Moossavi S. (2011)
    912. HER2 status in gastro-oesophageal adenocarcinomas ass essed by two rabbit monoclonal antibodies (SP3 and 4B5) and two in situ hybridi zation methods (FISH and SISH). (PubMed id 21323962)1 Boers J.E....Methorst N. (2011)
    913. Impact of protein tyrosine kinase 6 (PTK6) on human e pidermal growth factor receptor (HER) signalling in breast cancer. (PubMed id 21380407)1 Ludyga N....Aubele M. (2011)
    914. Transcriptional and posttranslational up-regulation o f HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase. (PubMed id 21385943)1 Garrett J.T....Arteaga C.L. (2011)
    915. ErbB2 and NFkB overexpression as predictors of chemora diation resistance and putative targets to overcome resistance in muscle-invasiv e bladder cancer. (PubMed id 22102915)1 Koga F....Kihara K. (2011)
    916. The RNA-binding protein HuR opposes the repression of ERBB-2 gene expression by microRNA miR-331-3p in prostate cancer cells. (PubMed id 21971048)1 Epis M.R....Leedman P.J. (2011)
    917. Dual-colour HER2/chromosome 17 chromogenic in situ hy bridisation assay enables accurate assessment of HER2 genomic status in gastric cancer and has potential utility in HER2 testing of biopsy samples. (PubMed id 21757431)1 Yan B....Salto-Tellez M. (2011)
    918. Multicenter phase III randomized trial comparing doce taxel and trastuzumab with docetaxel, carboplatin, and trastuzumab as first-lin e chemotherapy for patients with HER2-gene-amplified metastatic breast cancer ( BCIRG 007 study): two highly active therapeutic regimens. (PubMed id 21115860)1 Valero V....Slamon D.J. (2011)
    919. Successful treatment of a patient with HER2-positive m etastatic gastric cancer with third-line combination therapy with irinotecan, 5- fluorouracil, leucovorin and trastuzumab (FOLFIRI-T). (PubMed id 21985855)1 Weissinger F....Kruger M. (2011)
    920. Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. (PubMed id 21852536)1 Grassian A.R....Brugge J.S. (2011)
    921. ERBB2 is a target for USP8-mediated deubiquitination. (PubMed id 21044682)1 Meijer I.M. and van Leeuwen J.E. (2011)
    922. HER2 amplification, overexpression and score criteria in esophageal adenocarcinoma. (PubMed id 21460800)1 Hu Y....Zhou Z. (2011)
    923. Prognostic molecular markers in women aged 35 years o r younger with breast cancer: is there a difference from the older patients? (PubMed id 21642658)1 Lin C.H....Cheng A.L. (2011)
    924. Identification of the coexisting HER2 gene amplificat ion and novel mutations in the HER2 protein-overexpressed mucinous epithelial o varian cancer. (PubMed id 21347793)1 Lin W.L....Han C.P. (2011)
    925. Sarcosine induces increase in HER2/neu expression in androgen-dependent prostate cancer cells. (PubMed id 21755295)1 Dahl M....Bouchelouche K. (2011)
    926. HER2 status in a population-derived breast cancer coh ort: discordances during tumor progression. (PubMed id 20628810)1 Wilking U....Bergh J. (2011)
    927. Blood type, hormone receptor status, HER2/neu status, and survival in breast cancer: a retrospective study exploring relationships in a phenotypically well-defined cohort. (PubMed id 21263059)1 Klimant E....Onitilo A.A. (2011)
    928. Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma. (PubMed id 21966491)1 Menju T....Sabe H. (2011)
    929. Specific inhibition of a pathogenic receptor tyrosine kinase by its transmembrane domain. (PubMed id 20713021)1 He L....Hristova K. (2011)
    930. Modular anti-EGFR and anti-Her2 targeting of SK-BR-3 and BT474 breast cancer cell lines in the presence of ErbB receptor-specific gr owth factors. (PubMed id 21786419)1 Diermeier-Daucher S....Brockhoff G. (2011)
    931. hTERT regulation by NF-I_B and c-myc in irradiated HER 2-positive breast cancer cells. (PubMed id 21627565)1 Papanikolaou V....Tsezou A. (2011)
    932. A molecularly annotated platform of patient-derived xe nografts ('xenopatients') identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer. (PubMed id 22586653)1 Bertotti A....Trusolino L. (2011)
    933. Cyclin D3 compensates for the loss of cyclin D1 during ErbB2-induced mammary tumor initiation and progression. (PubMed id 22037875)1 Zhang Q....Wagner K.U. (2011)
    934. Discovery of new molecular subtypes in oesophageal ade nocarcinoma. (PubMed id 21966358)1 Berg D....Becker K.F. (2011)
    935. Neuregulin-1-human epidermal receptor-2 signaling is a central regulator of pulmonary epithelial permeability and acute lung injury. (PubMed id 21247898)1 Finigan J.H....Kern J.A. (2011)
    936. HER-2 positive and p53 negative breast cancers are as sociated with poor prognosis. (PubMed id 21599513)1 Al-azawi D....Young L. (2011)
    937. Threonine 22 phosphorylation attenuates Hsp90 interac tion with cochaperones and affects its chaperone activity. (PubMed id 21419342)1 Mollapour M....Neckers L. (2011)
    938. HER2-positive status is an independent predictor for coexisting invasion of ductal carcinoma in situ of the breast presenting extens ive DCIS component. (PubMed id 21095069)1 Liao N....Wu Y.L. (2011)
    939. [Expression of C-erbB-2 and EGFR expression and its r elationship with cell proliferation in nasopharyngeal carcinoma]. (PubMed id 21473138)1 Zhang Y....Liu Z. (2011)
    940. Quantum dots-based double-color imaging of HER2 posit ive breast cancer invasion. (PubMed id 21609713)1 Liu X.L....Li Y. (2011)
    941. Hormone receptor and ERBB2 status in gene expression profiles of human breast tumor samples. (PubMed id 22022496)1 Dvorkin-Gheva A. and Hassell J.A. (2011)
    942. Potent anti-proliferative effects of metformin on tras tuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor int eractions. (PubMed id 21862872)1 Liu B....Thor A.D. (2011)
    943. Ductal invasive mammary carcinoma--clinicopathological prognostic factors related to immunohistochemical expression of hormonal recept ors and Her2/neu oncoprotein. (PubMed id 22119825)1 Recareanu F....Pirici E. (2011)
    944. Nottingham Prognostic Index in triple-negative breast cancer: a reliable prognostic tool? (PubMed id 21762477)1 Albergaria A....Schmitt F. (2011)
    945. Dual-color silver-enhanced in situ hybridization for assessing HER2 gene amplification in breast cancer. (PubMed id 21317877)1 Koh Y.W....Gong G. (2011)
    946. Lack of replication for the association between HER2 I 655V polymorphism and breast cancer risk: a systematic review and meta-analysis. (PubMed id 21474413)1 Dahabreh I.J. and Murray S. (2011)
    947. HER2 codon 655 G-allele is associated with reductions in plasma high-density lipoprotein levels in breast cancer patients treated with tamoxifen. (PubMed id 21997313)1 Chang N.W....Wu C.T. (2011)
    948. Expression of endoplasmic reticulum stress proteins is a candidate marker of brain metastasis in both ErbB-2+ and ErbB-2- primary brea st tumors. (PubMed id 21708117)1 Sanz-Pamplona R....Sierra A. (2011)
    949. Highly efficient production of anti-HER2 scFv antibod y variant for targeting breast cancer cells. (PubMed id 21538107)1 Sommaruga S....Prosperi D. (2011)
    950. Her-2/neu amplification determined by real-time quanti tative PCR and its association with clinical outcome of breast cancer in Thailan d. (PubMed id 22126548)1 Chariyalertsak S....Vinyuvat S. (2011)
    951. Aberrant expression of the human epidermal growth fac tor receptor 2 oncogene is not a common feature in osteosarcoma. (PubMed id 21292304)1 Baumhoer D....Nathrath M. (2011)
    952. Immunohistochemical (IHC) HER-2/neu and fluorescent-in situ hybridization (FISH) gene amplification of breast cancer in Indian women. (PubMed id 21517254)1 Singhai R....Patil A. (2011)
    953. ERBB2 juxtamembrane domain (trastuzumab binding site) gene mutation is a rare event in invasive breast cancers overexpressing the ER BB2 gene. (PubMed id 21499233)1 Khoury T....Cheney R.T. (2011)
    954. Low frequency of HER2 amplification and overexpressio n in early onset gastric cancer. (PubMed id 21394646)1 Moelans C.B....van Diest P.J. (2011)
    955. HER2 gene amplification occurs frequently in the micr opapillary variant of urothelial carcinoma: analysis by dual-color in situ hybr idization. (PubMed id 21516078)1 Ching C.B....Hansel D.E. (2011)
    956. Targeting trastuzumab-resistant breast cancer cells w ith a lentivirus engineered to bind antibodies that recognize HER-2. (PubMed id 20232140)1 Zhang K.X....Rennie P.S. (2011)
    957. [Detection of human epidermal growth factor receptor 2 gene in invasive breast cancer by fluorescence in situ hybridization and resear ch of its association with tumor characteristics]. (PubMed id 21503112)1 Su J....Zheng J. (2011)
    958. Overexpression of HER2 signaling to WAVE2-Arp2/3 comp lex activates MMP-independent migration in breast cancer. (PubMed id 20419393)1 Yokotsuka M....Mukai K. (2011)
    959. TOPOIIalpha and HER-2/neu overexpression/amplificatio n in Barrett's oesophagus, dysplasia and adenocarcinoma. (PubMed id 20557373)1 Rossi E....Cestari R. (2010)
    960. A pilot study of adjuvant nanoparticle albumin-bound (nab) paclitaxel and cyclophosphamide, with trastuzumab in HER2-positive patien ts, in the treatment of early-stage breast cancer. (PubMed id 20658263)1 Yardley D....Hainsworth J. (2010)
    961. Endocrine resistance associated with activated ErbB s ystem in breast cancer cells is reversed by inhibiting MAPK or PI3K/Akt signali ng pathways. (PubMed id 19609946)1 Ghayad S.E....Cohen P.A. (2010)
    962. HER2 silences tumor suppression in breast cancer cell s by switching expression of C/EBPA9 isoforms. (PubMed id 21098707)1 Arnal-EstapAc A....Gomis R.R. (2010)
    963. Increased HER2/neu expression in recurrent hormone re ceptor-positive breast cancer. (PubMed id 19839717)1 Kaklamani V.G....O'Regan R.M. (2010)
    964. [Expression of HER-2/neu oncogene in hepatocellular c arcinoma and the clinical implications]. (PubMed id 20159713)1 Zhang J.K....Peng J.W. (2010)
    965. Comparison of microarray-based RNA expression with EL ISA-based protein determination of HER2, uPA and PAI-1 in tumour tissue of pati ents with breast cancer and relation to outcome. (PubMed id 20204407)1 Witzel I.D....MA1ller V. (2010)
    966. Genome profiling of ERBB2-amplified breast cancers. (PubMed id 20932292)1 Sircoulomb F....Chaffanet M. (2010)
    967. Expression of ErbB-1 and ErbB-2 in meningioma. (PubMed id 20547458)1 Wickremesekera A....Kaye A.H. (2010)
    968. The oncotype DX recurrence score is correlated with a composite index including routinely reported pathobiologic features. (PubMed id 20873988)1 Geradts J..