Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ERBB2 Gene

Aliases for ERBB2 Gene

  • Erb-B2 Receptor Tyrosine Kinase 2 2 3 5
  • V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 2 3
  • Tyrosine Kinase-Type Cell Surface Receptor HER2 3 4
  • Neuro/Glioblastoma Derived Oncogene Homolog 2 3
  • Human Epidermal Growth Factor Receptor 2 2 3
  • Metastatic Lymph Node Gene 19 Protein 3 4
  • Proto-Oncogene C-ErbB-2 3 4
  • Proto-Oncogene Neu 3 4
  • EC 2.7.10.1 4 61
  • P185erbB2 3 4
  • MLN 19 3 4
  • HER2 3 4
  • NGL 3 4
  • NEU 3 4
  • V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 (Neuro/Glioblastoma Derived Oncogene Homolog) 2
  • V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog 3
  • V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncoprotein 2 3
  • Neuroblastoma/Glioblastoma Derived Oncogene Homolog 3
  • Receptor Tyrosine-Protein Kinase ErbB-2 3
  • C-Erb B2/Neu Protein 3
  • CD340 Antigen 4
  • HER-2/Neu 3
  • Herstatin 3
  • EC 2.7.10 61
  • CD340 3
  • HER-2 3
  • MLN19 4
  • TKR1 3

External Ids for ERBB2 Gene

Previous HGNC Symbols for ERBB2 Gene

  • NGL

Previous GeneCards Identifiers for ERBB2 Gene

  • GC17P037262
  • GC17P039854
  • GC17P037766
  • GC17P038231
  • GC17P035109
  • GC17P037844
  • GC17P033638

Summaries for ERBB2 Gene

Entrez Gene Summary for ERBB2 Gene

  • This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for ERBB2 Gene

ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with ERBB2 include Glioma Susceptibility 1 and Ovarian Cancer, Somatic. Among its related pathways are RET signaling and Glioma. GO annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is EGFR.

UniProtKB/Swiss-Prot for ERBB2 Gene

  • Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

  • In the nucleus is involved in transcriptional regulation. Associates with the 5-TCAAATTC-3 sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.

Tocris Summary for ERBB2 Gene

  • The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4). EGFR signaling drives many cellular responses.

Gene Wiki entry for ERBB2 Gene

PharmGKB "VIP" Summary for ERBB2 Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for ERBB2 Gene

Genomics for ERBB2 Gene

Regulatory Elements for ERBB2 Gene

Enhancers for ERBB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F040088 1.8 FANTOM5 Ensembl ENCODE 10.9 +407.4 407434 14.4 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 MSL1 CDK12 IGFBP4 MED1 ENSG00000266469 MED24 GSDMA MIR6884 THRA ERBB2
GH17F039766 1.7 FANTOM5 Ensembl ENCODE 11.5 +87.0 86974 17.2 HDGF PKNOX1 WRNIP1 SIN3A FEZF1 ZNF2 CBX5 FOS SP3 JUNB CDK12 GSDMB ENSG00000266469 MED1 ORMDL3 SNORA21 GSDMA ERBB2 MIEN1 GRB7
GH17F039916 1.8 FANTOM5 Ensembl ENCODE 10.7 +235.5 235455 14.4 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ORMDL3 GSDMB IGFBP4 ENSG00000264968 MED1 ENSG00000266469 CDK12 ERBB2 GSDMA IKZF3
GH17F038850 1.5 FANTOM5 ENCODE 10.9 -834.4 -834416 5.2 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 RPL23 ENSG00000266469 CDK12 SNORA21 PCGF2 ERBB2 ENSG00000276170 ENSG00000275532 RPL19 MED1
GH17F040217 1.4 FANTOM5 ENCODE 10.9 +531.2 531207 2.8 HDGF PKNOX1 ARNT MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 MED1 ENSG00000266469 IGFBP4 CDK12 RAPGEFL1 LOC105371776 PGAP3 ERBB2 RPL23AP75 ENSG00000266208
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ERBB2 on UCSC Golden Path with GeneCards custom track

Promoters for ERBB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001345751 86 1601 PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 KLF13

Genomic Location for ERBB2 Gene

Chromosome:
17
Start:
39,687,914 bp from pter
End:
39,730,426 bp from pter
Size:
42,513 bases
Orientation:
Plus strand

Genomic View for ERBB2 Gene

Genes around ERBB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERBB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERBB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERBB2 Gene

Proteins for ERBB2 Gene

  • Protein details for ERBB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04626-ERBB2_HUMAN
    Recommended name:
    Receptor tyrosine-protein kinase erbB-2
    Protein Accession:
    P04626
    Secondary Accessions:
    • B2RZG3
    • B4DHN3
    • Q14256
    • Q6LDV1
    • Q9UMK4
    • X5D2V5

    Protein attributes for ERBB2 Gene

    Size:
    1255 amino acids
    Molecular mass:
    137910 Da
    Quaternary structure:
    • Homodimer. Heterodimer with EGFR, ERBB3 and ERBB4. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with PRKCABP and PLXNB1. Interacts (when phosphorylated on Tyr-1248) with MEMO1. Interacts with MUC1; the interaction is enhanced by heregulin (HRG). Interacts (when phosphorylated on Tyr-1139) with GRB7 (via SH2 domain). Interacts (when phosphorylated on Tyr-1248) with ERBIN. Interacts with KPNB1, RANBP2, EEA1, CRM1, CLTC, PTK6, RPA94 and ACTB. Interacts with SRC and MYOC (By similarity). Interacts (preferentially with the tyrosine phosphorylated form) with CPNE3; this interaction occurs at the cell membrane and is increased in a growth factor heregulin-dependent manner (PubMed:20010870).

    Three dimensional structures from OCA and Proteopedia for ERBB2 Gene

    Alternative splice isoforms for ERBB2 Gene

neXtProt entry for ERBB2 Gene

Selected DME Specific Peptides for ERBB2 Gene

P04626:
  • GGKVPIKW
  • KPYDGIP
  • SPLQRYSEDPT
  • RPRFRELV
  • LQVFETLEEITGYLYISAWP
  • QCAAGCTGP
  • FLRGQECV
  • RDLAARN
  • LDEAYVMA
  • CPYNYLST
  • AENPEYL
  • RLLGICLTS
  • MVKCWMID
  • TYNTDTFESM
  • RPAGATLERPKTLSP
  • LVDAEEYLVPQQGFF
  • MARDPQR
  • YALAVLDN
  • PLQRLRIVRGTQLFED
  • VKIPVAIK
  • GERLPQP
  • DSTFYRSLLEDDDMG
  • RLVHRDLAARNVLVKSPNHVKITDFGLARLL
  • SDVWSYGVT
  • CQPCPINCTHSC
  • YGVTVWE
  • KETELRK
  • RGRLGSQDLLNWC
  • GERLPQPPICTI
  • TQLMPYGCLLD
  • ETDGYVAPL
  • GLRELQLRSLTEILKGGVLI
  • GCPAEQRASP
  • ELVEPLTPSG
  • AARNVLV

Post-translational modifications for ERBB2 Gene

  • Autophosphorylated. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit (Probable). Ligand-binding increases phosphorylation on tyrosine residues (PubMed:27134172). Signaling via SEMA4C promotes phosphorylation at Tyr-1248 (PubMed:17554007). Dephosphorylated by PTPN12 (PubMed:27134172).
  • Ubiquitination at Lys 736, Lys 747, and Lys 753
  • Glycosylation at Asn 68, Asn 124, Asn 187, Asn 259, Asn 530, Asn 571, and Asn 629
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ERBB2 (HER2)

Protein Products

Domains & Families for ERBB2 Gene

Graphical View of Domain Structure for InterPro Entry

P04626

UniProtKB/Swiss-Prot:

ERBB2_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
genes like me logo Genes that share domains with ERBB2: view

Function for ERBB2 Gene

Molecular function for ERBB2 Gene

GENATLAS Biochemistry:
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog 2,HERC2/neu receptor tyrosine kinase,neuroglioblastoma derived,constitutively acting as a coreceptor for multiple stroma-derived growth factors i.e EGF-like ligands and neuregulins after heterodimerization with other ERBBs,involved in androgen receptor transactivation of inducing prostate-specific antigen (PSA) through the MAP kinase pathway,signal transducer,also presenting as a secreted transcript herstatin,expressed in normal fetal kidney and liver,potential inhibitor of ERBB2,commonly amplified in primary breast cancer and in endometrial cancer,coamplified with GRB7 in primary gastric cancer,and in prostate carcinoma with metastasis and poor prognosis
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by dimerization. Not activated by EGF, TGF-alpha and amphiregulin. Interaction with PTK6 increases its intrinsic kinase activity.
UniProtKB/Swiss-Prot Function:
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
UniProtKB/Swiss-Prot Function:
In the nucleus is involved in transcriptional regulation. Associates with the 5-TCAAATTC-3 sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.

Enzyme Numbers (IUBMB) for ERBB2 Gene

Gene Ontology (GO) - Molecular Function for ERBB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001042 RNA polymerase I core binding IDA 21555369
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA,TAS --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IEA,IDA 7514177
genes like me logo Genes that share ontologies with ERBB2: view
genes like me logo Genes that share phenotypes with ERBB2: view

Human Phenotype Ontology for ERBB2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ERBB2 Gene

MGI Knock Outs for ERBB2:

Animal Model Products

miRNA for ERBB2 Gene

miRTarBase miRNAs that target ERBB2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for ERBB2 Gene

Localization for ERBB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERBB2 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1.
Isoform 2: Cytoplasm. Nucleus.
Isoform 3: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERBB2 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
endosome 5
extracellular 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ERBB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 16314522
GO:0005737 cytoplasm IEA,IDA --
GO:0005886 plasma membrane NAS,TAS --
GO:0010008 endosome membrane IDA 16314522
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ERBB2: view

Pathways & Interactions for ERBB2 Gene

SuperPathways for ERBB2 Gene

SuperPathway Contained pathways
1 RET signaling
2 GPCR Pathway
3 GAB1 signalosome
4 Signaling by ERBB2
5 Glioma
genes like me logo Genes that share pathways with ERBB2: view

SIGNOR curated interactions for ERBB2 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ERBB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001934 positive regulation of protein phosphorylation ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006468 protein phosphorylation IEA,TAS 10851066
genes like me logo Genes that share ontologies with ERBB2: view

Drugs & Compounds for ERBB2 Gene

(154) Drugs for ERBB2 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lapatinib Approved March 2007, Investigational Pharma Inhibition, inhibitor, Biomarker, Target, antagonist EGFR/HER2 inhibitor,potent,selective and reversible, HER2 and EGFR kinase inhibitor, HER2 Inhibitors, Kinase Inhibitors, Epidermal growth factor receptor (EGFR) inhibitors 296
Pertuzumab Approved Pharma Biomarker, antibody, inhibitor, Target HER2 Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors, HER2 Dimerization Inhibitor 118
Trastuzumab Approved, Investigational Pharma antagonist, Biomarker, antibody, inhibitor, Target HER2 antagonist, HER2 Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 766
trastuzumab emtansine Approved Pharma Target, antibody 0
afatinib Approved Pharma inhibitor, Target Kinase Inhibitors, Epidermal growth factor receptor (EGFR) inhibitors 0

(51) Additional Compounds for ERBB2 Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
AG 490
133550-30-8
AV 412
451492-95-8
CP 724714
383432-38-0
PF 6274484
1035638-91-5

(5) Tocris Compounds for ERBB2 Gene

Compound Action Cas Number
AG 490 EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor 133550-30-8
AV 412 Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases 451492-95-8
CP 724714 Potent and selective ErbB2 inhibitor 383432-38-0
Iressa Orally active, selective EGFR inhibitor 184475-35-2
PF 6274484 High affinity and potent covalent EGFR kinase inhibitor 1035638-91-5

(26) ApexBio Compounds for ERBB2 Gene

Compound Action Cas Number
AC480 (BMS-599626) HER1/2 inhibitor,selective and efficacious 714971-09-2
AEE788 (NVP-AEE788) EGFR/HER-2/VEGFR inhibitor 497839-62-0
Afatinib (BIBW2992) Irreversible EGFR/HER2 inhibitor 439081-18-2
Afatinib dimaleate 850140-73-7
AG 825 Selective ErbB2 inhibitor 149092-50-2
AG-1478 EGFR inhibitor,potent and selective 153436-53-4
ARRY-380 Tyrosine kinase HER2 and p95-HER2 inhibitor 937265-83-3
AST-1306 EGFR/HER2 inhibitor 897383-62-9
AST-1306 TsOH ErbB2 and EGFR inhibitor 1050500-29-2
AV-412 EGFR/ErbB2 kinase inhibitor 451493-31-5
AV-412 free base EGFR/ErbB2 kinase inhibitor 451492-95-8
AZD8931 (Sapitinib) ErbB inhibitor 848942-61-0
BMS 599626 dihydrochloride EGFR and ErbB2 inhibitor,potent and selective
BMS-599626 Hydrochloride EGFR/HER2 inhibitor,potent and selective 873837-23-1
Canertinib (CI-1033) HER family tyrosine kinase inhibitor 267243-28-7
Canertinib dihydrochloride Pan-ErbB inhibitor, potent and selective 289499-45-2
CP-724714 HER2 inhibitor,potent and selective 537705-08-1
Dacomitinib (PF299804, PF299) HER inhibitor 1110813-31-4
erbB-2 Tyrosine kinase (TK) receptor
Lapatinib EGFR/HER2 inhibitor,potent,selective and reversible 231277-92-2
Mubritinib (TAK 165) 366017-09-6
Neratinib (HKI-272) HER2/EGFR inhibitor,potent and irreversible 698387-09-6
Poziotinib irreversible pan-HER inhibitor 1092364-38-9
TAK-285 HER2/EGFR(HER1) inhibitor 871026-44-7
Tyrphostin AG 879 148741-30-4
Varlitinib (ARRY334543) ErbB inhibitor 845272-21-1
genes like me logo Genes that share compounds with ERBB2: view

Drug Products

Transcripts for ERBB2 Gene

Unigene Clusters for ERBB2 Gene

V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian):
Representative Sequences: