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ERBB2 Gene

protein-coding GIFtS: 79

GC17P037844

v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
(Previous name: v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: NGL)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases & Descriptions
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)¹ ²		TKR1²
HER2¹ ² ³ ⁵		c-erb B2/neu protein²
NEU¹ ² ³ ⁵		MLN19³
NGL² ³ ⁵		Tyrosine kinase-type cell surface receptor HER2³
CD340¹ ²		Metastatic lymph node gene 19 protein³
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)¹ ²		p185erbB2³
HER-2¹ ²		EC 2.7.10.1³
neuroblastoma/glioblastoma derived oncogene homolog²		MLN 19³
erbB-2²		Proto-oncogene c-ErbB-2³
herstatin²		CD340 antigen³
HER-2/neu²		Proto-oncogene Neu³

External Ids:	HGNC: 3430¹	Entrez Gene: 2064²	Ensembl: ENSG00000141736⁷	UniProtKB: P04626³

Search outside databases for aliases for ERBB2 gene

Previous GC identifers: GC17P037262 GC17P039854 GC17P037766 GC17P038231 GC17P035109

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ERBB2:

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This

protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind

tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and

enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated

protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a

(positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here.

Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian

tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and

others that have not been fully characterized. (provided by RefSeq)

UniProtKB/Swiss-Prot: ERBB2_HUMAN, P04626

Function: Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone.

GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin

summary for ERBB2:

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members of

the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4). EGFR

signaling is initiated by ligand binding to the extracellular ligand binding domain. This initiates receptor

homo-/hetero-dimerization and autophosphorylation by the intracellular kinase domain, resulting in receptor

activation. Following activation, phosphorylation of cytoplasmic substrates occurs and a signaling cascade

is initiated that drives many cellular responses, including changes in gene expression, cytoskeletal

rearrangement, anti-apoptosis and increased cell proliferation.

Gene Wiki entry for ERBB2 (HER2/neu)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
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Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ERBB2 gene upstream (promoter) region

:
STAT1beta STAT1 STAT1alpha ATF-2 HNF-4alpha2 Elk-1 c-Myb PPAR-gamma1 PPAR-gamma2 COUP-TF1

Epigenetics:

Search SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for ERBB2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2-q12|17q21.1 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q11.2-q12

ERBB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P037844: view genomic region (about GC identifiers)

Start:	37,844,393 bp from pter
End:	37,884,915 bp from pter
Size:	40,523 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.10 NT_010783.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: ERBB2_HUMAN, P04626 (See protein sequence)

Recommended Name: Receptor tyrosine-protein kinase erbB-2 precursor

Size: 1255 amino acids; 137910 Da

Subunit: Heterodimer with each of the other ERBB receptors (Potential). Interacts with PRKCABP and PLXNB1. Part of a

complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts

with MEMO when phosphorylated on Tyr-1248. Interacts with MUC1. Stimulation by heregulin (HRG) in breast cancer cell

lines induces binding of MUC1 with gamma-catenin

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structures from and Proteopedia :

1MFG (3D)

1MFL (3D)

1MW4 (3D)

1N8Z (3D)

1OVC (3D)

1QR1 (3D)

1S78 (3D)

2A91 (3D)

2JWA (3D)

3BE1 (3D)

Secondary accessions: B2RZG3 Q14256 Q6LDV1 Q9UMK4

Post-translational modifications:

Ligand-binding increases phosphorylation on tyrosine residues (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001005862.1 NP_004439.2

ENSEMBL proteins:

ENSP00000385185 ENSP00000269571 ENSP00000404047

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins and AQUA Peptides and CompoZr ZFN for ERBB2
	R&D Systems Recombinant & Natural Proteins for ERBB2 (ErbB2/Her2)
	Enzo Life Sciences proteins for ERBB2
	HuPro® and/or Recombinant Proteins from Abnova for ERBB2
	Origene Purified Recombinant Human Protein: ERBB2
	Novus Biologicals Protein for ERBB2
	Novus Biologicals Lysate for ERBB2
	Browse Sino Biological Recombinant Proteins

5/14 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 14 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	NAS	12000754
GO:0005902	microvillus	IEA	--
GO:0009925	basal plasma membrane	IEA	--

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ERBB2 for ontologies About GeneDecksing

Antibodies for ERBB2:

	Millipore Mono- and Polyclonal Antibodies for the study of ERBB2
	Sigma-Aldrich Antibody Arrays and Antibodies for ERBB2
	R&D Systems Antibodies for ERBB2 (ErbB2/Her2)
	Cell Signaling Technology (CST) Antibodies for ERBB2 (HER2/ErbB2)
	Monoclonal and Polyclonal Antibodies from Abnova (ERBB2)
	Origene Antibodies (see all 4): ERBB2
	Novus Biologicals Antibodies for ERBB2
	Epitomics antibodies for ERBB2

Assays for ERBB2:

	Millipore Kits and Assays for the Analysis of ERBB2
	Browse ELISAs at Sigma-Aldrich
	R&D Systems ELISAs for ERBB2 (ErbB2/Her2)
	Cell Signaling Technology (CST) Sandwich ELISA Kits for ERBB2 (HER2/ErbB2)
	Browse Enzo Life Sciences for kits & assays

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ERBB2 for domains About GeneDecksing

5/12 InterPro domains/families (see all 12 ):

IPR017441 Protein_kinase_ATP_BS

IPR006212 Furin_repeat

IPR011009 Kinase-like_dom

IPR000719 Prot_kinase_cat_dom

IPR020685 Tyr_prot_kinase

Graphical View of Domain Structure for InterPro Entry P04626

ProtoNet protein and cluster: P04626

5 Blocks protein families:

IPB000494 Epidermal growth-factor receptor (EGFR)

IPB004019 YLP motif

IPB006211 Furin-like cysteine rich region

IPB006212 Furin-like repeat

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: ERBB2_HUMAN, P04626

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily

Similarity: Contains 1 protein kinase domain

(According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
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Inhib. RNA:		Millipore RNAi Products for the Analysis of ERBB2 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (ERBB2)
		Origene 29mer shRNA kits in GFP-retroviral vector (see all 2): ERBB2 Origene shRNA RFP (see all 2): ERBB2 Origene basic RS shRNA (see all 2): ERBB2
		Applied Biosystems Silencer® siRNAs for ERBB2
		Sigma-Aldrich siRNA Panels and siRNA for ERBB2 Sigma-Aldrich shRNA Panels and shRNA for ERBB2 Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		Origene GFP tagged cDNA clones in CMV expression vector (see all 2): ERBB2 Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ERBB2 Origene untagged cDNA clones in CMV expression vector (see all 4): ERBB2
		Sino Biological Human cDNA Clone for ERBB2

UniProtKB/Swiss-Prot: ERBB2_HUMAN, P04626

Function: Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone.

GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.1

Genatlas biochemistry entry for ERBB2:

avian erythroblastic leukemia viral (v-erb-b) oncogene homolog 2,HERC2/neu receptor tyrosine kinase,neuroglioblastoma

derived,constitutively acting as a coreceptor for multiple stroma-derived growth factors i.e EGF-like ligands and

neuregulins after heterodimerization with other ERBBs,involved in androgen receptor transactivation of inducing

prostate-specific antigen (PSA) through the MAP kinase pathway,signal transducer,also presenting as a secreted

transcript herstatin,expressed in normal fetal kidney and liver,potential inhibitor of ERBB2,commonly amplified in

primary breast cancer and in endometrial cancer,coamplified with GRB7 in primary gastric cancer,and in prostate

carcinoma with metastasis and poor prognosis

5/21 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 21 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0001948	glycoprotein binding	IEA	--
GO:0004672	protein kinase activity	--	--
GO:0004674	protein serine/threonine kinase activity	--	--
GO:0004713	protein tyrosine kinase activity	IGI	7556068

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Animal Models: 15/19 MGI mutant phenotypes (inferred from 17 alleles) (MGI details for Erbb2) (see all 19 ):

behavior/neurological	cardiovascular system	craniofacial	digestive/alimentary	embryogenesis
endocrine/exocrine gland	growth/size	homeostasis/metabolism	lethality-postnatal	lethality-prenatal/perinatal
life span-post-weaning/aging	limbs/digits/tail	muscle	nervous system	normal

ERBB2 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
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ERBB2 for pathways About GeneDecksing

5/8 Millipore Pathways for ERBB2 (see all 8 )

	Apoptosis and survival Role of CDK5 in neuronal death and survival
	Development EGFR signaling pathway
	Development TGF-beta receptor signaling
	Translation Non-genomic (rapid) action of Androgen Receptor
	Development Ligand-independent activation of ESR1 and ESR2

5/8 Sigma-Aldrich "Your Favorite Gene" Pathways for ERBB2 (Your Favorite Gene powered by Ingenuity) (see all 8 )

	Pancreatic Adenocarcinoma Signaling
	Non-Small Cell Lung Cancer Signaling
	Axonal Guidance Signaling
	Bladder Cancer Signaling
	Endometrial Cancer Signaling

5/41 GeneAssist Pathways for ERBB2 (see all 41 )

	Nanog in Mammalian ESC Pluripotency
	ErbB4 Pathway
	Alzheimer's Disease Pathway
	ERK Signaling
	ErbB Family Pathway

2 Cell Signaling Technology (CST) Pathways for ERBB2:

	Translational Control: Regulation of eIF4E and p70 S6 Kinase
	Protein Acetylation

5/10 Kegg Pathways (Kegg details for ERBB2) (see all 10 ):

	hsa04012 ErbB signaling pathway
	hsa04020 Calcium signaling pathway
	hsa04510 Focal adhesion
	hsa04520 Adherens junction
	hsa05200 Pathways in cancer

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ERBB2

5/132 Interacting proteins for ERBB2 (ENSP00000269571³ P04626^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 132 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EGFR	P00533¹^,²	STRING: ENSP00000275493 EBI-641062,EBI-297353 MINT-1788719 EBI-641062,EBI-297353 MINT-1788719
SHC1	P29353²	STRING: ENSP00000357432 MINT-61510 MINT-61506 MINT-74737 MINT-61504 MINT-74734 MINT-74736 MINT-61508 MINT-74733 MINT-74735 MINT-61511
PIK3R3	Q92569²	STRING: ENSP00000262741 MINT-74664 MINT-74642 MINT-74650 MINT-74662 MINT-74660 MINT-74649 MINT-74663 MINT-74641 MINT-74661
ERBB3	P21860¹	STRING: ENSP00000267101 EBI-641062,EBI-720706
ERBB4	Q15303¹	STRING: ENSP00000342235 EBI-641062,EBI-80371

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5/37 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 37 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001889	liver development	IEA	--
GO:0006468	protein amino acid phosphorylation	TAS	10851066
GO:0007165	signal transduction	IDA	10572067
GO:0007166	cell surface receptor linked signaling pathway	IDA	9685399
GO:0007167	enzyme linked receptor protein signaling pathway	TAS	9590694

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ERBB2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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ERBB2 for compounds About GeneDecksing

Enzo Life Sciences drugs & compounds for ERBB2

Sigma-Aldrich Small Molecules for ERBB2:

Small Molecule - Inhibitor

Compounds for ERBB2 available from Tocris Bioscience

Compound	Action	CAS number
GW 583340 dihydrochloride	Potent dual EGFR/ErbB2 inhibitor; orally active	[388082-81-3]
HDS 029	Potent inhibitor of the ErbB receptor family
JNJ 28871063 hydrochloride	Potent ErbB receptor family inhibitor	[944341-54-2]
TAK 165	Potent and selective ErbB2 inhibitor	[366017-09-6]
PD 158780	Potent ErbB receptor family inhibitor	[171179-06-9]

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10/507 Novoseek chemical compound relationships for ERBB2 gene (see all 507 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cb 11	100.00	81	17158643 (4), 16373062 (4), 12669615 (3), 11759828 (3) (see all 60)
tyrosine	100.00	1173	1352772 (8), 1706346 (7), 8637714 (6), 16287490 (6) (see all 100)
pertuzumab	100.00	78	19920829 (6), 20124183 (4), 20124182 (4), 17635517 (4) (see all 37)
lapatinib	100.00	287	14751502 (7), 20179222 (6), 19858400 (6), 19060928 (6) (see all 100)
progesterone	100.00	1055	15743737 (7), 19629680 (5), 1345772 (5), 8758245 (4) (see all 100)
trastuzumab	100.00	1997	16865596 (10), 18769124 (8), 15780499 (8), 12384528 (8) (see all 100)
gefitinib	97.68	167	15899817 (7), 17347776 (6), 12684395 (6), 17638894 (5) (see all 90)
geldanamycin	71.51	90	11071886 (10), 11018093 (7), 9009164 (5), 18765569 (5) (see all 30)
tamoxifen	68.96	304	11032587 (8), 11774281 (7), 18245484 (6), 17636399 (6) (see all 100)
ag 825	68.20	36	8640763 (6), 11606371 (3), 19513620 (2), 17138652 (2) (see all 27)

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8 PharmGKB drug compound relationships for ERBB2 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
5-fluorouracil	CO FA	12973835
GW2016	FA	12467226
canertinib	FA	12006493
cyclophosphamide	CO FA	12973835
docetaxel	FA	14578462
gemcitabine	FA	14578462
methotrexate	CO FA	12973835
trastuzumab	FA	14578462

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Millipore RNAi Products for the Analysis of ERBB2 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (ERBB2)
		Applied Biosystems Silencer® siRNAs: NM_001005862 NM_004448
		Origene 29mer shRNA kits in GFP-retroviral vector (see all 2): ERBB2 Origene shRNA RFP (see all 2): ERBB2 Origene basic RS shRNA (see all 2): ERBB2
		Sigma-Aldrich siRNA Panels and siRNA for ERBB2 Sigma-Aldrich shRNA Panels and shRNA for ERBB2 Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:

Search SABiosciences for microRNAs that regulate ERBB2:

Assays:

Applied Biosystems TaqMan® Gene Expression Assays:

NM_001005862 NM_004448

Clones:

Origene GFP tagged cDNA clones in CMV expression vector (see all 2): ERBB2
Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ERBB2
Origene untagged cDNA clones in CMV expression vector (see all 4): ERBB2

Primers:		Origene genome-wide validated SYBR primer pairs: ERBB2
		SABiosciences RT2 qPCR Primer Assay for ERBB2: PPH00209A

REFSEQ mRNAs for ERBB2 gene (2 alternative transcripts):

NM_001005862.1 NM_004448.2

Additional cDNA sequence:

AB025286.1 AF177761.2 AK295195.1 AK296908.1 AK300321.1 AK309029.1 AK313683.1 BC080193.1

BC110392.1 BC167147.1 CR591377.1 CR592336.1 M11730.1 S57296.1 X03363.1

24/27 DOTS entries (see all 27 ):

DT.100824047 DT.95088838 DT.120977168 DT.215753 DT.75117810 DT.97759791 DT.120977079 DT.95261294

DT.100824051 DT.100824052 DT.70100272 DT.75191397 DT.100824048 DT.75167343 DT.95256387 DT.91699968

DT.91727209 DT.92025980 DT.95090252 DT.100731961 DT.100738418 DT.120664712 DT.120977138 DT.120977177

24/323 AceView cDNA sequences (see all 323 ):

CA455141 CA445529 CA487981 CA488343 CA454131 AA765693 BM789286 CB129403

CB305806 BU632568 BQ717097 AA025156 BM672297 BM758528 BM829991 AA508596

BU845391 BX479682 BQ213570 CA495357 AW264076 BE349874 AA613049 AW175631

highest scoring ESTs for ERBB2:

M11730 X03363 AA025141 AA025156 AA156513 AA293095 AA293749 AA446928 AA480116 AA481939

Unigene Cluster for ERBB2:

V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)

Hs.446352 [show with all ESTs]

Unigene Representative Sequence: NM_001005862

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ERBB2 (see all 6 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	·	15c	^	16	^	17	^	18	^	19	^	20	^	21	^
SP1:							-																												-
SP2:																																			-
SP3:							-
SP4:																																									-
SP5:

ExUns:	22	^	23a	·	23b	^	24	^	25	^	26	^	27a	·	27b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ERBB2

3 Ensembl transcripts including schematic representations:

ENST00000406381 ENST00000269571 ENST00000445658

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
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ERBB2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ERBB2

¹ / ² / ³

9 probe-sets matching ERBB2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1802_s_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.72	X03363	1.00	1.00	1.00	1
33218_at²^{, 3}	U95-A	1	1.00	1.00	0.95	1.31	M11730	1.00	1.00	1.00	1
1901_s_at²^{, 3}	U95-A	1	1.00	1.00	0.68	1.04	M12036	0.20	1.00	0.72	1
210930_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF177761	0.60	1.00	0.82	1
216836_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	X03363	1.00	1.00	1.00	1
234354_x_at²^{, 3}	U133-B	1	0.46	1.00	--	--	S57296	0.40	1.00	0.76	1
210930_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216836_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
234354_x_at²	U133Plus2	1	0.46	1.00	--	--	--	--	--	--	--

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ERBB2 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

About these images

CGAP SAGE TAG: AGGAAGGAAC

SOURCE GeneReport for Unigene cluster: Hs.446352

Expression variation in blood from EXPOLDB for ERBB2

Primers:		Origene genome-wide validated SYBR primer pairs: ERBB2
		SABiosciences RT2 qPCR Primer Assay for ERBB2: PPH00209A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ERBB2 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ERBB2¹	--	v-erb-b2 erythroblastic leukemia viral oncogene homolog more	90.78(n) 92.66(a)	403883 NM_001003217.1 NP_001003217.1
rat (Rattus norvegicus)	Erbb2¹	--	v-erb-b2 erythroblastic leukemia viral oncogene homolog more	85.9(n) 88.13(a)	24337 NM_017003.2 NP_058699.2
mouse (Mus musculus)	Erbb2^{1, 5}	11 (57.00 cM)⁵	v-erb-b2 erythroblastic leukemia viral oncogene homolog more^{1, 5}	85.6(n)¹ 87.73(a)¹	13866¹ NM_001003817.1¹ NP_001003817.1¹ AK031099⁵ AK031542⁵ (see all 24)
chicken (Gallus gallus)	ERBB2¹	--	v-erb-b2 erythroblastic leukemia viral oncogene homolog more	73.11(n) 71.83(a)	426130 NM_001044661.1 NP_001038126.1
zebrafish (Danio rerio)	erbb2¹	--	v-erb-b2 erythroblastic leukemia viral oncogene homolog more	60.69(n) 59.08(a)	386966 NM_200119.2 NP_956413.2

About this table Species with no ortholog for ERBB2

ENSEMBL Gene Tree for ERBB2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ERBB2 gene

EPHB1² SYK² EPHB3² EPHA2² EPHA5² EPHA4² EPHB6² ENSG00000183317²

ERBB4² EPHA7² PTK2² ZAP70² EGFR² EPHB4² TNK1² EPHA6²

TNK2² EPHA1² EPHB2² ERBB3² EPHA8² EPHA3² PTK2B² EPHA10²

ERBB2 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
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UniProtKB/Swiss-Prot: ERBB2_HUMAN, P04626

Polymorphism: There are fours alleles due to the variations in positions 654 and 655. Allele B1 (Ile-654/Ile-655) has a

frequency of 0.782; allele B2 (Ile-654/Val-655) has a frequency of 0.206; allele B3 (Val-654/Val-655) has a frequency

of 0.012

10/102 NCBI SNPs in ERBB2 are shown (see all 102 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 68)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Related Data				Allele Frequencies
				--	--	--		--	--			--
--	rs2934971^1,2	C,F,A,H	33648334(+)	`atagaT/Gtcaag`	2	--	int¹ ng5¹		7	NS EA NA	308
--	rs4252596^1,2	C,F	33649661(+)	`GGAAGC/ACACAA`	2	--	int¹ ng5¹		11	NS EA NA	1022
--	rs4252661^1,2	C,F	37884888(+)	`GTCCAT/CTTGCA`	2	--	ut3¹		2	NS WA	170
--	rs1801201^1,2	C,F	37879585(+)	`CGTCCA/GTCATC`	4	I V	ref¹ mis¹		5	MN	404
--	rs4252658^1,2	C,F	37884363(+)	`TTCTGC/TTGGCA`	2	--	ut3¹ ese³		5	NS EA	554
--	rs4252599^1,2	C,F	33649945(+)	`CGTCCC/TGGCGC`	2	--	ng5¹ int¹		1	NS	172
	rs1136201^1,2	C,F	37879588(+)	`CCATCA/GTCTCT`	4	I V	ref¹ mis¹		37	MN EA NS NA	4720
	rs2230700^1,2	H	37884302(+)	`AACCAG/TAAGGC`	2	--	ut3¹ ese³		5	MN NS EA	462
	rs4252633^1,2	C	37872035(+)	`AGCTGG/TCTGGG`	4	W C	ref¹ mis¹ ese³		1	NS	172
--	rs4252659^1,2	C	37884372(+)	`CATCAA/-GAGGT`	2	--	ut3¹		1	NS	150

About this table

HapMap Linkage Disequilibrium images for ERBB2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ERBB2
1 CNV: 77592

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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ERBB2 for disorders About GeneDecksing

OMIM: 164870

UniProtKB/Swiss-Prot: ERBB2_HUMAN, P04626

Defects in ERBB2 are associated with gastric cancer [MIM:137215]; also known as hereditary familial diffuse

gastric cancer (HDGC)

Defects in ERBB2 are associated with familial glioma of brain [MIM:137800]; also called glioblastoma

multiforme. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas,

glioblastoma multiforme, oligodendrogliomas, and ependymomas

Defects in ERBB2 are associated with ovarian cancer [MIM:167000]. Ovarian cancer is the leading cause of death

from gynecologic malignancy. It is characterized by advanced presentation with loco-regional dissemination in the

peritoneal cavity and the rare incidence of visceral metastases. These typical features relate to the biology of the

disease, which is a principal determinant of outcome

Defects in ERBB2 are associated with lung cancer [MIM:211980]; also called adenocarcinoma of lung

10/878 Novoseek disease relationships for ERBB2 gene (see all 878 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	100.00	6151	11489825 (9), 19077306 (8), 17786307 (8), 12698536 (8) (see all 100)
ovarian cancer	100.00	628	8094034 (7), 7906607 (6), 7904177 (6), 7835782 (6) (see all 100)
breast cancer metastatic	100.00	512	19620495 (7), 20178580 (5), 19885560 (5), 19729798 (5) (see all 100)
invasive breast cancer	100.00	281	18971621 (5), 8543395 (3), 19764994 (3), 19732720 (3) (see all 100)
invasive ductal carcinoma	100.00	189	16681686 (5), 20108215 (4), 16169726 (4), 18681318 (3) (see all 100)
dcis	100.00	313	7955870 (9), 15696127 (8), 2170971 (7), 19383888 (7) (see all 100)
breast tumor	100.00	639	8816486 (5), 19148488 (5), 9188464 (4), 8723884 (4) (see all 100)
her-2 gene amplification	100.00	221	10921034 (8), 7615357 (6), 7591299 (6), 15217943 (6) (see all 100)
polysomy 17	100.00	84	18794552 (9), 18681318 (5), 19214111 (4), 17761736 (4) (see all 43)
primary tumor	80.37	283	15786420 (7), 11489824 (6), 18836203 (5), 18097576 (5) (see all 100)

About this table

2 PharmGKB disease relationships for ERBB2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Breast Neoplasms	CO FA	12973835 14578462
Neoplasms	FA	12006493 12467226

About this table

Human Gene Mutation Database: ERBB2
Genetic Association Database: ERBB2
Human Genome Epidemiology Navigator: ERBB2 (128 documents)
Tumor Gene Database: ERBB2
Breast Cancer Gene Database: ERBB2

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/4845 PubMed articles for ERBB2 gene (see all 4845 ):

A single nucleotide polymorphism in the transmembrane domain coding region of HER-2 is associated with development and malignant phenotype of gastric cancer. (PubMed id 14520697)^{1, 3, 6} Kuraoka K....Yasui W. (2003)
The influence of HER2 genotypes as molecular markers in ovarian cancer outcome. (PubMed id 16112085)^{1, 3, 6} Pinto D....Medeiros R. (2005)
EGFR and erbB2 mutation status in Japanese lung cancer patients. (PubMed id 16003726)^{1, 3, 6} Sasaki H....Fujii Y. (2006)
Her2 genotype and breast cancer progression in Korean women. (PubMed id 15693849)^{1, 3, 6} An H.J....Lee K.S. (2005)
The association of p53 mutations and p53 codon 72, Her 2 codon 655 and MTHFR C677T polymorphisms with breast cancer in Northern Greece. (PubMed id 15837541)^{1, 3, 6} Kalemi T.G....Kotsis A. (2005)
Vitamin D receptor, HER-2 polymorphisms and risk of prostate cancer in men with benign prostate hyperplasia. (PubMed id 15083213)^{1, 3, 6} Tayeb M.T....McLeod H.L. (2004)
Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2. (PubMed id 15210733)^{1, 3, 4} Swiercz J.M.... Offermanns S. (2004)
Memo mediates ErbB2-driven cell motility. (PubMed id 15156151)^{1, 3, 4} Marone R.... Badache A. (2004)
No association between HER-2 gene polymorphism at codon 655 and a risk of bladder cancer. (PubMed id 11857355)^{1, 3, 6} Wang L....Kato T. (2002)
Association of HER-2 polymorphism with Japanese sporadic prostate cancer susceptibility. (PubMed id 15389808)^{1, 3, 6} Yokomizo A....Naito S. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2064	HGNC: 3430	AceView: ERBB2	Ensembl:ENSG00000141736	euGenes: HUgn2064
ECgene: ERBB2	Kegg: 2064	H-InvDB: ERBB2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for ERBB2	Genetics and Cytogenetics in Oncology and Haematology
Mammary Transgene Database entry for ERBB2	More genetic and clinical information
NIEHS-SNPs	http://egp.gs.washington.edu/data/erbb2/
Wikipedia	http://en.wikipedia.org/wiki/ERBB2

Intellectual Property for ERBB2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for ERBB2 gene:

Search GeneIP for patents involving ERBB2

Licensable Technologies for ERBB2 gene:

Weizmann Institute:

Combination of Anti-ErbB-2 monoclonal Ab for treating cancer

(see all 2)

GeneCards and IP:

Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ERBB2:

TaqMan ® Gene Expression Assays

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Free SNP selection tool

	Millipore Custom Antibody & Bulk Services
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ERBB2 (Gene Symbol)
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
HER2
NEU
NGL
CD340
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
HER-2
neuroblastoma/glioblastoma derived oncogene homolog
erbB-2
herstatin
HER-2/neu
TKR1
c-erb B2/neu protein
MLN19
Tyrosine kinase-type cell surface receptor HER2
Metastatic lymph node gene 19 protein
p185erbB2
EC 2.7.10.1
MLN 19
Proto-oncogene c-ErbB-2
CD340 antigen
Proto-oncogene Neu

cystic hypersecretory carcinoma
breast mouse
high-grade squamous intraepithelial lesion
malformation
salivary gland carcinoma
lung tumor
malignant pleural effusion
relapse
skin ulcer
h pylori infection
neurofibrosarcoma
papillary adenocarcinoma
cecal carcinoma
gastrinoma
cystic fibrosis
thymoma
polysomy
breast cancer stage iiia
actinic keratosis
braf gene mutation
extramammary paget disease
metaplasia
colorectal adenocarcinoma
nasal polyp
endometrial cancer, stage
invasive; mole
neuroblastoma
human mammary carcinoma
hidradenoma
pituitary carcinoma
skin metastases
volume overload
malignant rhabdoid tumor
failure heart
ovarian clear cell adenocarcinoma
adenoviral infection
pancreatic endocrine tumor
lymphoma
cholecystitis chronic
atypical fibrocystic disease
heterotopia
pancreatitis
intestinal metaplasia
adpkd
malignant skin adnexal tumor
spindle cell tumor
scirrhous carcinoma
stage iiia nsclc
androgen independent prostate cancer
low-grade glioma
ovarian serous carcinoma
gastric cancer stage iii
pelvic endometriosis
cns malignancy
metastasis
skeletal ewings sarcoma
adenocarcinoma endometrial
clear cell chondrosarcoma
necrosis
primary glioblastoma
pkhd1
NF2
endometrial cancer metastatic
stage i nsclc
prostate tumor
glioblastoma multiforme
testis cancer
chondrosarcoma
graves ophthalmopathy
oral mucosal disorder
ascites malignant
pin-1
colorectal cancer dukes c
pyometra
epithelial tumor
metastatic carcinoma
b-cell lymphoma
low-grade dcis
osteosarcoma
diffuse hyperplasia
head cancer
prostate cancer stage
scirrhous breast carcinoma
tumor initiation
non-invasive breast carcinoma
desmoid tumor
tubular adenocarcinoma
esophageal adenocarcinoma
intraductal papillary adenocarcinoma
granulosa cell tumor
pituitary tumor
atypical medullary carcinoma
viral leukemia
immune dysfunction
colon cancer stage ii
benign schwannoma
ewing sarcoma
benign tumor
nbccs
traumatic neuroma
gene abnormality
pediatric solid tumor
ovarian granulosa cell tumor
accreta; placenta
EPs
benign colorectal neoplasm
primary mucinous carcinoma
active chronic hepatitis
invasive breast cancer
ovarian cancer stage
escc
ovarian epithelial tumor
invasive micropapillary breast carcinoma
bone sarcoma
skin appendage tumour
medullary thyroid carcinoma
papilloma
bone disease
chronic heart failure
fatty liver
hepatocarcinogenesis
breast-ovarian cancer
atypical hyperplasia
growth suppression
cystic disease
benign prostatic hypertrophy
dermatofibrosarcoma
wallerian degeneration
NF1
sarcoma, endometrial stromal, low-grade
inflammatory disease
adenocarcinoma lung
atypical carcinoid tumor
stromal tumor
laryngeal papilloma
extensive disease
autoimmune disease
malignant myoepithelioma
cervical cancer stage
barrett epithelium
breast cancer
increased requirement
infarction; myocardial
breast metastasis
refractory cancer
induration
carcinoma transitional cell
tumor promotion
cervical intraepithelial neoplasia
chromosomal aberration
glassy cell carcinoma
cancer occult
carcinoma; lipid-rich
childhood medulloblastoma
colonic adenoma
carcinoma; nasopharyngeal
vascular proliferation
ebv infection
effusion
sweat gland carcinoma
nonfunctioning pituitary adenoma
burkitt lymphoma
CHF
intraepithelial carcinoma
cervical cancer
anemia
cancer other
asbestosis
mdm2 gene amplification
parotid gland adenocarcinoma
pelvic cancer
8 trisomy
prostatic adenocarcinoma
apocrine tumor
neuroendocrine tumor
CLL
breast cancer metastatic
colon; lesion
mpnst
crouzon syndrome
hepatoblastoma
lichen planus
dlbcl
metastatic pancreatic adenocarcinoma
minor salivary gland mucoepidermoid carcinoma
transgenic model
atypical adenomatous hyperplasia
gynecologic cancer
c-met gene amplification
replication error
medulloblastoma
ocular sebaceous carcinoma
2 trisomy
glioma
adenosis
hormone-refractory prostate cancer
tripe palms
adenoma; basal cell
acute myeloid leukemia
parotid tumor
carcinoma; renal cell
brain lesion
complete mole
cholangioma
papillary serous carcinoma
uterine tumor
NPC
neurofibroma
cardiac carcinoma
hidradenocarcinoma
sebaceous adenoma
metastatic renal cell carcinoma
schistosomiasis
follicular carcinoma
derivative chromosome
neoplastic process
paraneoplastic syndrome
enzyme inhibition
metastatic gastric cancer
synchronous bilateral breast carcinoma
immature teratoma
early gastric cancer
borderline ovarian tumor
refractory tumor
biliary tract cancer
delay; developmental
serous carcinoma
hyperplastic nodule
trophoblastic tumor
metastatic ovarian carcinoma
c-cell hyperplasia
von willebrand
eccrine neoplasm
endometrial cancer
gallbladder adenocarcinoma
vulvar pagets disease
adenosis sclerosing
brca1 mutation
biliary disease
intrahepatic cholangiocarcinoma
adenoid cystic carcinoma
egfr protein overexpression
papillomavirus infection
pancreatic ductal adenocarcinoma
dysplasia
tumor growth
anaplastic astrocytoma
fgfr1 gene amplification
salivary gland tumor
borderline ovarian mucinous tumor
extra-adrenal pheochromocytoma
gastrointestinal cancer
insertion mutation
cancer
fallopian tube carcinoma
embryonal carcinoma
cutaneous melanoma
inverted nasal papilloma
dupuytrens disease
basal cell carcinoma
growth arrest
cystadenoma serous
low-grade squamous intraepithelial lesion
ductal hyperplasia
diffuse type carcinoma
invasive lobular carcinoma
cell transformation
vascular tumor
precancerous lesions
physiological stress
pnets
colorectal adenoma
intestinal type adenocarcinoma
breast cancer stage ii
inflammatory cell infiltration
lobular carcinoma
gynecomastia
brain tumor
carcinoma; thymic
prostate cancer recurrent
monosomies
chronic gastritis
pheochromocytoma
breast cancer, familial
papillary carcinoma
fibrosarcoma
hashimoto thyroiditis
sinonasal undifferentiated carcinoma
vulvar squamous cell carcinoma
testicular germ cell tumor
malignant glioma
adenoma; hepatocellular
ataxia telangiectasia
acute pancreatitis recurrent
epithelial hyperplasia
hyperdiploidy
skin tumor
hyperplasia
large cell neuroendocrine carcinoma
locally advanced cancer
RA
ppnet
breast cancer stage iii
brca2 mutation
gliosis
ampullary carcinoma
leukemia
conventional chondrosarcoma
hydatidiform mole
mixed germ cell tumor
parotid cancer
oropharyngeal squamous cell carcinoma
acinic cell carcinoma
pancreatic cancer
hematologic malignancies
axillary metastases
nonseminomatous germ cell tumor
nuclear alteration
cutaneous squamous cell carcinoma
vestibular schwannoma
barrett adenocarcinoma
SCC
localized disease
carcinoma gallbladder
syndrome, wiskott-aldrich
disease graves
radiation-induced dna damage
chronic hyperplastic candidosis
xenograft model
autoimmune
invasive growth
cardiomyopathies
egfr gene amplification
medullary breast carcinoma
breast cancer stage
familial cancer
inflammatory response
tumor angiogenesis
infection viral
adenomatous polyp
microsatellite instability
proliferative breast disease
retinoblastoma
adult t-cell leukemia
thymic neoplasia
gynecologic tumor
urological cancer
ovarian mucinous carcinoma
gynecologic disease
teratocarcinoma
melanoma metastatic
autoimmunities
gastric adenoma
inflammatory neuropathy
carcinoma poorly differentiated
cervical lesion
ganglioneuroblastoma
asthma
advanced cancer
seminoma
tumor vasculature
basal cell hyperplasia
jaundice
adenocarcinoma gastric
disease; hodgkin
papillary serous endometrial carcinoma
oligoastrocytoma
immunodeficiency
ovarian cystadenocarcinoma
atypical endometrial hyperplasia
hepatitis b
endometrial endometrioid adenocarcinoma
effusion pleural
clear cell carcinoma
cancer recurrence
multicore
malignant mesothelioma
pediatric osteosarcoma
death neonatal
soft tissue tumor
sarcoma
microglandular adenosis
hypersensitivities
skin hyperplasia
recurrent tumor
genomic instabilities
adrenocortical tumor
mammary adenocarcinoma
invasive carcinoma
her-2 positive breast cancer
unilateral breast cancer
serous effusion
gastric lesion
uterine carcinosarcoma
lead line
liposarcoma
lobular neoplasia
ovarian endometrioid carcinoma
typical carcinoid
calcification
carcinoid
laryngeal squamous cell carcinoma
aberrant dna methylation
squamous cell carcinoma differentiated
gestational choriocarcinoma
atypical intraductal hyperplasia
erythroblastosis
tumorigenicity
adenomatous hyperplasia
skin cancer
malignant pheochromocytoma
chondrosarcoma mesenchymal
AD
lymph node cancer
adenocarcinoma metastatic
atypical alveolar hyperplasia
extensive stage small cell lung cancer
pediatric brain tumor
prostate cancer metastatic bone
benign pheochromocytoma
allelic imbalance
cancer differentiated poorly
infectious
trisomies
liver metastases
apocrine carcinoma
secretory carcinoma
peripheral nerve tumor
chronic liver disease
ovarian tumor
measle
hot spots
ovarian adenocarcinoma
ovarian lymphoma
bone metastases
pregnancy loss
hepatic necrosis
cartilaginous tumor
renal tumor
synovial sarcoma
monosomy 3
cystitis
comedo
benign ovarian tumor
cancer relapse
gastric intestinal type adenocarcinoma
lymphocytic infiltrate
herpes simplex
germline mutation
endometrioma
breast papillomatosis
fallopian tube adenocarcinoma
hepatic insufficiency
tumor morphology
hidrocystoma
aneuploid
bronchioloalveolar carcinoma
neurodegenerative disease
squamous cell carcinoma tongue
multiple tumors
CJD
COPD
bladder adenocarcinoma
cardiac defect
premalignant lesion
inflammatory myofibroblastic tumor
gene fusion
epithelioid sarcoma
malignant disease
estrogenic effect
metaplastic carcinoma
charcot-marie-tooth disease type 1
disease; liver
lesion; primary
chromosomal duplication
desmoplastic small round cell tumor
sebaceous hyperplasia
parotid pleomorphic adenoma
ovarian cancer
prion disease
cirrhosis (liver)
esophageal dysplasia
epithelial proliferation
extrahepatic bile duct carcinoma
cervical cancer stage iii
pterygium
large cell carcinoma
reflux
solid carcinoma
cervical squamous cell carcinoma
insulinoma
homogeneously staining region
endometrial tumor
carcinoma ex pleomorphic adenoma
endometrioid tumor
sebaceous carcinoma
papillary urothelial neoplasm
dupuytren
sclc
immunosuppression
aortic stenosis
colorectal cancer metastatic
adenomatous polyposis coli
ovarian cystadenoma
piles
lymph node metastasis
hepatitis c
growth delay
neoplastic transformation
fibrocystic change
adenoma tubular
salivary gland mucoepidermoid carcinoma
colon cancer
desmoplasia
parotid mucoepidermoid carcinoma
hyperprolactinemia
papillomatosis
tetanus
ACBCC
noninvasive ductal carcinoma
astrocytoma
contralateral breast cancer
salivary gland adenocarcinoma
thyroid cancer
gastrointestinal tumor
chemoradiation
venezuelan equine encephalomyelitis
cerebellar degeneration
acute lymphoblastic leukemia
endometrial stromal sarcoma
aromatase activity, increased
breast disease fibrocystic
keratoacanthoma
breast cancer recurrent
clear cell tumor
trisomy 17
adrenocortical carcinoma
myocardial necrosis
liver dysfunction
undifferentiated carcinoma
uveal melanoma
cholangiocarcinoma
teratoma
senile plaque
warthin tumor
lymphoma (non-hodgkins)
chronic hepatitis b
central osteosarcoma
type ii endometrial carcinoma
multiple myeloma
metastatic pancreatic cancer
brcax
papillary hyperplasia
sebaceoma
leiomyosarcoma
stomatitis
abdominal tumor
vascular disease
cholecystitis
choriocarcinoma
epispadia
mammary paget disease
immune tolerance
peritoneal carcinomatosis
erbb2 protein overexpression
non-small cell carcinoma
periampullary carcinoma
erythroleukemia
polycystic liver disease
postoperative infection
cns lesion
differentiated thyroid carcinoma
endometrium; postmenopausal
lung cancer
cystic neoplasm
systemic disease
role playing
lymphatic metastasis
intraductal proliferative lesion
isochromosome 17q
myelodysplastic syndrome
neuroblastoma stage
brain metastases
SCID
malignant lacrimal gland tumor
paget disease
carcinosarcoma
somatic mutation
squamous intraepithelial lesion
panin
colon adenocarcinoma
shock
polysomy 17
dominant-negative mutant
colorectal cancer
delayed-type hypersensitivity
hnscc
rectal cancer
papillary transitional cell carcinoma
cyst; inclusion
embryonal rhabdomyosarcoma
cysts
oral cancer
hepatitis
pleomorphic adenoma
colonic disease
adnexal carcinoma
serous neoplasm
malignant conversion
extravasation
atrophic gastritis
childhood cancer
colon tumor
exstrophy
gastric cancer
barrett esophagus
melanoma
tumor progression
chromosomal gain
lobular hyperplasia
adenosquamous carcinoma
ovarian cancer recurrent
uterine sarcoma
bone tumor
nodular hidradenoma
severe dysplasia
carcinoma endometrial recurrent
high-grade prostatic intraepithelial neoplasia
adenocarcinoma differentiated poorly
botryoid sarcoma
obese
tongue cancer
reactive hyperplasia
eruption
ventricular dysfunction
neuroendocrine carcinoma
leydig cell tumor
microcystic adnexal carcinoma
apocrine metaplasia
neurofibromatosis
aggressive behavior
alveolar rhabdomyosarcoma
neuroblastic tumor
lymphoepithelioma-like carcinoma
bronchial dysplasia
meningioma
anaplastic meningioma
basal cell carcinoma sclerosing type
mature teratoma
desmoplastic trichoepithelioma
pancreatic tumor
disease; lung
breast disease
pelvic tumor
metastatic prostate cancer
cyst; ovarian
solid tumor
microcalcification
chronic myeloid leukemia
partial mole
plaques; pleural
mucinous cystadenocarcinoma
primary disease
leukoplakia oral
schwannoma
clear cell endometrial carcinoma
oncogene activation
metaplastic breast carcinoma
skin toxicity
fibrosis progressive massive
intestinal cancer
endometrial hyperplasia
cervical carcinoma, invasive
fatal outcome
brain tumor malignant
residual tumor
endometriosis
residual cancer
anaplasia
lung metastases
phyllodes tumor
c-kit mutation
cyclin d1 gene amplification
nsclc
primary tumor
carcinoma endometrial stage i
hereditary gingival fibromatosis
renal cell carcinoma 2
disease characteristic
tumor necrosis
rhabdomyosarcoma
break, double-strand dna
ovarian cancer stage i
cervical cancer recurrent
oncogenesis
SMS
intraepithelial prostatic neoplasia
malignant primary brain tumor
acute promyelocytic leukemia
cervical adenocarcinoma
lung neuroendocrine tumor
polyp
ulcer
gallbladder adenoma
primary peritoneal carcinoma
MS
cardiomyopathy dilated
breast cancer stage i
colorectal cancer stage ii
fibrous histiocytoma malignant
SARS
metastatic squamous cell carcinoma
mucinous tumor
bladder transitional cell carcinoma
embryonal tumor
peritoneal metastases
thyroid follicular cell tumor
lymphocytic infiltration
atrioventricular canal
carcinoma papillary thyroid
bladder; lung
urothelial dysplasia
myoepithelioma
oesophageal
bile duct carcinoma
stage iii nsclc
adult soft tissue sarcoma
primary sclerosing cholangitis
angiosarcoma
endocrine tumor
desmoplastic
papillary tumor
multiple cancer
vulvar carcinoma
multiple endocrine neoplasia
benign prostate hyperplasia
cystadenoma
minimal residual disease
squamous cell carcinoma
metastatic malignant melanoma
atypical lobular hyperplasia
mammary ductal carcinoma
endometrioid carcinoma
tumor escape
comedo carcinoma
chromosomal instabilities
pterygia
trigeminal schwannoma
chromosome 8 trisomy
hypocellular
adenofibroma
charcot-marie-tooth disease type 1a
hypertrophies
pneumoconiosis
ureteral cancer
colorectal tumor
adnexal tumor
stasis
adenoma
salivary duct carcinoma
atypical meningioma
mesothelioma
polysomy 3
lung cancer non-small cell recurrent
GISTs
bilateral breast cancer
sporadic breast cancer
cholesteatoma middle ear
respiratory papillomatosis
monosomy 17
signet-ring cell carcinoma
neurologic diseases
malignant transformation
dcis
skin carcinogenesis
who grade i meningioma
kaposi sarcoma
apocrine breast carcinoma
metastatic bladder cancer
gastric tumor
squamous cell carcinoma lung
hypoxic
cellular stress
increased drug resistance
inflammatory breast cancer
colloid goiter
cancer cell growth
adenocarcinoma
germ cell tumor
tumor; wilms
neck cancer
mucoepidermoid carcinoma
lacrimal gland tumor
ureter tumor
endometrial polyp
adenoma villous
leukoplakia
benign breast tumor
acute pancreatitis
neck cancer squamous cell
neck tumor
inflammation
keratocyst
cirrhosis; postnecrotic
malignant mixed tumor
trichilemmal carcinoma
failure liver
intestinal obstruction
tetrasomy
prostate cancer
mammary tumorigenesis
carcinoma hepatocellular
pancreatic adenocarcinoma
glioblastoma
fibroadenoma
lymphoid tumor
glomerulonephritis proliferative
dysplasia; epithelial
gastric dysplasia
adenosarcoma
intermediate-grade dcis
intraductal papilloma
tumor immunity
lung cancer stage i
primary brain tumor
bladder cancer
chromosome 7 trisomy
demyelination
adenocarcinoma lung stage i
uterine leiomyosarcoma
cholesteatoma
increased growth
osteoarthritis
double minutes
ethmoid sinus adenocarcinoma
uterine cancer
laryngeal carcinoma
invasive bladder cancer
haemophilus
epidermal hyperplasia
mucinous carcinoma
single tumor
telomere shortening
chordoma
breast tumor
gastric polyp
nuclear accumulation
invasive ductal carcinoma
paraganglioma
goiter
atypical cell
influenza
barrett metaplasia
class i; histocompatibility complex
neural tumor
her-2 gene amplification
precancerous condition
involvement, cns
c-myc gene amplification
gestational trophoblastic disease
cardia
retroviral infection
anaplastic thyroid carcinoma
angiofibroma
preneoplastic change
metastatic osteosarcoma
large breast
anal cancer
esophageal cancer
warburg effect
cholera
triton tumor
arthritis

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ERBB2 Gene

protein-coding GIFtS: 79

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