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Aliases & Descriptions for NR2F6
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EAR-2 1, 2 | | EAR2 2, 3, 5 | | ERBAL2 2, 3, 5 |
| | | Descriptions |
|---|
| ERBA-related gene-2 2 | | Orphan nuclear receptor EAR-2 3 | | V-erbA-related protein EAR-2 3 | | nuclear receptor subfamily 2, group F, member 6 2 | v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 2 2 |
|
| | Search outside databases for aliases for NR2F6 genePrevious GC identifers: GC19M017836 GC19M017734 GC19M017187 |
Summaries for NR2F6(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Gene Wiki entry for NR2F6 (V-erbA-related_gene) |
Genomic Location for NR2F6
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the NR2F6 gene 
Entrez Gene cytogenetic band: 19p13.1 Ensembl cytogenetic band: 19p13.11 HGNC chromosome: 19NR2F6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M017203:
(about GC identifiers)
Start:
|
17,203,694 bp from pter |
End:
|
17,217,151 bp from pter |
Size:
|
13,458 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011295.10
| Proteins for NR2F6
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: NR2F6_HUMAN, P10588 (See
protein sequence)Recommended Name: Nuclear receptor subfamily 2 group F member 6 Size: 404 amino acids; 42979 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q5XGA0 Q6P586 Q9BUE8Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005225.2
ENSEMBL proteins: ENSP00000291442
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: NR2F6 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for NR2F6: Assays for NR2F6: | Protein
Domains/ Families for NR2F6(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P10588
ProtoNet protein and cluster: P10588 3 Blocks protein families: IPB001723 Steroid hormone receptor signature IPB003068 COUP transcription factor (2F nuclear receptor) family signature IPB013629 Zinc finger
UniProtKB/Swiss-Prot: NR2F6_HUMAN, P10588Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamilySimilarity: Contains 1 nuclear receptor DNA-binding domain | Gene Function for NR2F6
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005234
Applied Biosystems Silencer® siRNAs for NR2F6
Sigma-Aldrich siRNA and siRNA Panels for NR2F6  Sigma-Aldrich shRNA Panels and shRNA for NR2F6  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005234                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005234                                  untagged cDNA clone in CMV expression vector: NM_005234 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005234
Genatlas biochemistry entry for NR2F6:nuclear receptor subfamily 2,group F,member 6,steroid/thyroid receptor superfamily3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Nr2f6):
5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): About this table | Pathways & Interactions for NR2F6
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for NR2F6 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for NR2F6 
5/32 Interacting proteins for NR2F6 (ENSP000002914423) via UniProtKB, MINT, and/or STRING (see all 32
)About this table
5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
): About this table
|
Drugs & Compounds for NR2F6(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for NR2F6
|
Transcripts for NR2F6(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005234
Sigma-Aldrich siRNA and siRNA Panels for NR2F6  Sigma-Aldrich shRNA Panels and shRNA for NR2F6  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005234 REFSEQ mRNAs for NR2F6 gene: NM_005234.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005234               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005234                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005234                                  untagged cDNA clone in CMV expression vector: NM_005234  Additional cDNA sequence: AB307712.1 AK298764.1 AK314961.1 BC002669.2 BC063018.1 BC084544.1 CR597276.1 10 DOTS entries: DT.97857739 DT.85102327 DT.100814198 DT.91761109 DT.95270826 DT.121502634 DT.121502680 DT.121502720 DT.121502725 DT.95249903 24/286 AceView cDNA sequences (see all 286
):AI523767 BE857117 AI369183 AA186362 BF515310 BM683296 AW006013 BQ581683 AA971961 AI910998 BF115666 BM915376 AI146583 AI675498 BM683601 T19367 CA391292 BX107591 BE222650 T19366 BQ961681 AW044448 AI609042 AI523309
highest scoring ESTs for NR2F6:AI146583 AI283138 AI334646 AI420770 AI467895 AI609042 AI675205 AI682355 AI769667 AI830334 Unigene Cluster for NR2F6: Nuclear receptor subfamily 2, group F, member 6 Hs.466148 [show with all ESTs]Unigene Representative Sequence: BC002669
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000291442
|
Expression for NR2F6
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| NR2F6 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for NR2F6
1 / 2 / 3 7 probe-sets matching NR2F6 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ATGACTCAAG
SOURCE GeneReport for Unigene cluster: Hs.466148
Expression variation in blood from EXPOLDB for NR2F6 |
Orthologs for NR2F6
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NR2F6 gene from 5/9 species (see all 9
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
NR2F61 |
-- |
nuclear receptor subfamily 2, group F, member 6 |
95.2(n) 99.5(a) |
609720 XM_860601.1 XP_865694.1 |
chimpanzee (Pan troglodytes) |
NR2F61 |
-- |
nuclear receptor subfamily 2, group F, member 6 |
99.01(n) 99.75(a) |
748739 XM_001173294.1 XP_001173294.1 |
cow (Bos taurus) |
NR2F61 |
-- |
nuclear receptor subfamily 2, group F, member 6 |
93.03(n) 98.76(a) |
528188 XM_606600.3 XP_606600.2 |
rat (Rattus norvegicus) |
Nr2f61 |
-- |
nuclear receptor subfamily 2, group F, member 6 |
88.17(n) 94.34(a) |
245980 NM_139113.1 NP_620813.1 |
mouse (Mus musculus) |
Nr2f61, 5 |
8 (33.50 cM)5
|
nuclear receptor subfamily 2, group F, member 61, 5 |
88.26(n)1 95.89(a)1 |
138641 NM_010150.21 NP_034280.21 AK1319415 AK1444755 (see all 16) |
About this table Species with no ortholog for NR2F6
ENSEMBL Gene Tree for NR2F6 | Paralogs for NR2F6(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for NR2F6 gene
- NR2F12 NR2F22
|
SNPs/Variants for NR2F6(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for NR2F6 (up to first 250kb)
|
Disorders & Mutations for NR2F6
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 132880
|
Medical News for NR2F6(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for NR2F6 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/15 PubMed articles for NR2F6 gene (see all 15
):- Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other. (PubMed id 2905047)2, 3, 4 Miyajima N.... Yamamoto T. (1988)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)3, 4 Beausoleil S.A....Gygi S.P. (2004)
- The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function. (PubMed id 10713182)1, 3 Zhu X.G....Cheng S.Y. (2000)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription. (PubMed id 12690040)3 Liu X....Sigmund C.D. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. (PubMed id 10644740)3 Zhang Y. and Dufau M.L. (2000)
- Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2. (PubMed id 10318855)3 Avram D....Leid M. (1999)
- Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1. (PubMed id 9226381)3 Bahler M....Olsen A.S. (1997)
|
Search for NR2F6
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NR2F6
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing NR2F6
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NR2F6(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for NR2F6(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for NR2F6:

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