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NR2F6 Gene

protein-coding   GIFtS: 60

GC19M017203
nuclear receptor subfamily 2, group F, member 6
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ERBAL2)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
EAR-2 1, 2
EAR2 2, 3, 5
ERBAL2 2, 3, 5
Descriptions
ERBA-related gene-2 2
Orphan nuclear receptor EAR-2 3
V-erbA-related protein EAR-2 3
nuclear receptor subfamily 2, group F, member 6 2
v-erb-a avian erythroblastic leukemia viral oncogene
homolog-like 2 2
External Ids
HGNC: 79771
Entrez Gene: 20632
UniProtKB: P105883
Ensembl: ENSG000001601137
Search outside databases for aliases for NR2F6 gene

Previous GC identifers: GC19M017836 GC19M017734 GC19M017187

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for NR2F6 (V-erbA-related_gene)
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the NR2F6 gene  

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.11   HGNC chromosome: 19

NR2F6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M017203:     (about GC identifiers)

Start:
17,203,694 bp from pter
End:
17,217,151 bp from pter
Size:
13,458 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000019.8  NT_011295.10  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NR2F6_HUMAN, P10588 (See protein sequence)
Recommended Name: Nuclear receptor subfamily 2 group F member 6  
Size: 404 amino acids; 42979 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q5XGA0 Q6P586 Q9BUE8

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_005225.2  

    ENSEMBL proteins: 
    ENSP00000291442 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (NR2F6)
    Human Recombinant Proteins from Abnova (NR2F6)
                  OriGene Purified Recombinant Human Protein: NR2F6 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for NR2F6: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for NR2F6
    R&D Systems Antibodies for NR2F6 (EAR2/NR2F6)
    Antibodies from Abcam (NR2F6), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (NR2F6)
    Novus Biologicals Antibodies for NR2F6

    Assays for NR2F6: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/7 InterPro domains/families (see all 7 ):
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR003068 COUP_TF


       GeneDecks  NR2F6 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P10588

    ProtoNet protein and cluster: P10588

    3 Blocks protein families:
    IPB001723 Steroid hormone receptor signature
    IPB003068 COUP transcription factor (2F nuclear receptor) family signature
    IPB013629 Zinc finger


    UniProtKB/Swiss-Prot: NR2F6_HUMAN, P10588
    Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (NR2F6)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (NR2F6)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005234

                  Applied Biosystems Silencer® siRNAs for NR2F6

                  Sigma-Aldrich siRNA and siRNA Panels for NR2F6  
                         Sigma-Aldrich shRNA Panels and shRNA for NR2F6  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005234
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005234
                                     untagged cDNA clone in CMV expression vector: NM_005234 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_005234

    Genatlas biochemistry entry for NR2F6:
    nuclear receptor subfamily 2,group F,member 6,steroid/thyroid receptor superfamily

    3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nr2f6):

    behavior/neurologicalnervous systemtouch/vibrissae

    5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700 transcription factor activity IEA--
    GO:0003707 steroid hormone receptor activity TAS2905047
    GO:0004887 thyroid hormone receptor activity TAS2905047
    GO:0008270 zinc ion binding IEA--
    GO:0043565 sequence-specific DNA binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    2 Sigma-Aldrich "Your Favorite Gene" Pathways for  NR2F6  (Your Favorite Gene powered by Ingenuity) 
     Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency
     RAR Activation

       GeneDecks  NR2F6 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  NR2F6 


    5/32 Interacting proteins for NR2F6 (ENSP000002914423) via UniProtKB, MINT, and/or STRING (see all 32 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR3C1ENSP000002315093STRING (score=.963)
    NR1D1ENSP000002466723STRING (score=.916)
    NCOR2ENSP000003485513STRING (score=.915)
    NCOR1ENSP000002687123STRING (score=.914)
    NR2C2ENSP000003204473STRING (score=.912)
    About this table

    5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0007165 signal transduction TAS2905047
    GO:0043153 entrainment of circadian clock by photoperiod IEA--
    GO:0048666 neuron development IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for NR2F6

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (NR2F6)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (NR2F6)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005234

                  Sigma-Aldrich siRNA and siRNA Panels for NR2F6  
                         Sigma-Aldrich shRNA Panels and shRNA for NR2F6  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_005234  

    REFSEQ mRNAs for NR2F6 gene: 

    NM_005234.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_005234  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005234
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005234
                                     untagged cDNA clone in CMV expression vector: NM_005234 

    Additional cDNA sequence: 

    AB307712.1 AK298764.1 AK314961.1 BC002669.2 BC063018.1 BC084544.1 CR597276.1 

    10 DOTS entries:

    DT.97857739  DT.85102327  DT.100814198  DT.91761109  DT.95270826  DT.121502634  DT.121502680  DT.121502720 
    DT.121502725  DT.95249903 

    24/286 AceView cDNA sequences (see all 286 ):

    AI523767 BE857117 AI369183 AA186362 BF515310 BM683296 AW006013 BQ581683 
    AA971961 AI910998 BF115666 BM915376 AI146583 AI675498 BM683601 T19367 
    CA391292 BX107591 BE222650 T19366 BQ961681 AW044448 AI609042 AI523309 

    highest scoring ESTs for NR2F6:

    AI146583 AI283138 AI334646 AI420770 AI467895 AI609042 AI675205 AI682355 AI769667 AI830334 

    Unigene Cluster for NR2F6:

    Nuclear receptor subfamily 2, group F, member 6
    Hs.466148  [show with all ESTs]
    Unigene Representative Sequence: BC002669


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000291442  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    NR2F6 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for NR2F6

    1 / 2 / 3

    7 probe-sets matching NR2F6 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    41310_f_at2, 3 U95-A 1 1.00 1.00 0.94 0.89 X12794 0.40 1.00 0.76 1
    1218_at2, 3 U95-A 1 1.00 1.00 0.98 0.92 X12794 0.40 1.00 0.76 1
    57829_s_at2, 3 U95-B 1 1.00 1.00 0.97 1.19 AI874405 0.80 1.00 0.91 1

    209261_s_at2, 3 U133-A 1 1.00 1.00 -- -- BF000629 0.80 1.00 0.91 1

    209262_s_at2, 3 U133-A 1 1.00 1.00 -- -- BC002669 0.80 1.00 0.91 1

    209261_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    209262_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  NR2F6 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: ATGACTCAAG

    SOURCE GeneReport for Unigene cluster: Hs.466148

    Expression variation in blood from EXPOLDB for NR2F6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for NR2F6 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    NR2F61   -- nuclear receptor subfamily 2, group F, member 6 95.2(n)
    99.5(a)
    609720  XM_860601.1  XP_865694.1 
    chimpanzee
    (Pan troglodytes)
    NR2F61   -- nuclear receptor subfamily 2, group F, member 6 99.01(n)
    99.75(a)
    748739  XM_001173294.1  XP_001173294.1 
    cow
    (Bos taurus)
    NR2F61   -- nuclear receptor subfamily 2, group F, member 6 93.03(n)
    98.76(a)
    528188  XM_606600.3  XP_606600.2 
    rat
    (Rattus norvegicus)
    Nr2f61   -- nuclear receptor subfamily 2, group F, member 6 88.17(n)
    94.34(a)
    245980  NM_139113.1  NP_620813.1 
    mouse
    (Mus musculus)
    Nr2f61, 5 8 (33.50 cM)5
    nuclear receptor subfamily 2, group F, member 61, 5 88.26(n)1
    95.89(a)1
    138641  NM_010150.21  NP_034280.21 
     AK1319415  AK1444755  (see all 16)
    About this table        Species with no ortholog for NR2F6

    ENSEMBL Gene Tree for NR2F6
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for NR2F6 gene
    NR2F12  NR2F22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/98 NCBI SNPs in NR2F6 are shown (see all 98 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 42)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs38267291,2
    A,C,F,H17219133(+) AACACA/GAAAAG 1 -- ng313Minor allele frequency- G:0.40EU EA 298
    --
    rs7510101,2
    A,C17203316(+) acagcA/Gaaact 1 -- ng510--------
    --
    rs20146861,2
    C17203664(+) aaaatA/Gaaaaa 1 -- ng510--------
    --
    rs10781271,2
    A17203315(+) aacagC/Tgaaac 1 -- ng510--------
    rs22885391,2
    C,F,H17212535(-) CGGAAC/TCAGTG 1 N/N syn1 ese35Minor allele frequency- T:0.19EA EU WA 1888
    rs48086101,2
    A,C,F,H17210306(+) aaaggC/Acccga 1 -- int14Minor allele frequency- A:0.01EU EA WA 416
    rs80998961,2
    A,C,F,H17214366(+) TCCCCT/CGTACC 1 -- int11Minor allele frequency- C:0.41EU 120
    rs8912051,2
    A,C,F,H17215586(-) GAGTGT/GCCCCA 1 -- int16Minor allele frequency- G:0.25EU EA WA NA 598
    rs48086111,2
    C,F,H17215825(+) GCTCGC/TCCGGG 1 -- int14Minor allele frequency- T:0.09EU EA WA 420
    rs81026671,2
    C,F,H17206675(+) aaaatA/Ggaaat 1 -- int14Minor allele frequency- G:0.01EU EA WA 416
    About this table

    HapMap Linkage Disequilibrium images for NR2F6 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 132880

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/15 PubMed articles for NR2F6 gene (see all 15 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 2063 HGNC: 7977 AceView: NR2F6 Ensembl:ENSG00000160113 euGenes: HUgn2063
    ECgene: NR2F6 H-InvDB: NR2F6
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for NR2F6 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for NR2F6:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for NR2F6 Antibodies for NR2F6
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for NR2F6 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant Proteins
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     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for NR2F6




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for NR2F6

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