Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ERAS Gene

protein-coding   GIFtS: 47
GCID: GC0XP048687

ES Cell Expressed Ras

(Previous name: v-Ha-ras Harvey rat sarcoma viral oncogene homolog pseudogene)
(Previous symbols: HRAS2, HRASP)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
ES Cell Expressed Ras1 2     E-Ras2 3
HRAS21 2 3 5     GTPase ERas2
HRASP1 2 3 5     Small GTPase Protein E-Ras2
V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog Pseudogene1 2     V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog 22
Embryonic Stem Cell-Expressed Ras2 3     

External Ids:    HGNC: 51741   Entrez Gene: 32662   Ensembl: ENSG000001876827   OMIM: 3004375   UniProtKB: Q7Z4443   

Export aliases for ERAS gene to outside databases

Previous GC identifers: GC0XU900451 GC0XP047733 GC0XP048443 GC0XP048572 GC0XP046346


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ERAS Gene:
This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein
activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is
not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance. (provided
by RefSeq, Dec 2012)

GeneCards Summary for ERAS Gene:
ERAS (ES cell expressed Ras) is a protein-coding gene. Diseases associated with ERAS include acquired immunodeficiency syndrome, and hypoplastic left heart syndrome. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is REM1.

UniProtKB/Swiss-Prot: RASE_HUMAN, Q7Z444
Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the
tumor-like growth properties of embryonic stem cells (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_079573.5  
Regulatory elements:
   Regulatory transcription factor binding sites in the ERAS gene promoter:
         AML1a   HNF-4alpha2   CUTL1   Cdc5   Roaz   HNF-4alpha1   Max   Cart-1   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidERAS promoter sequence
   Search Chromatin IP Primers for ERAS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ERAS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

ERAS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ERAS gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP048687:  view genomic region     (about GC identifiers)

Start:
48,687,283 bp from pter      End:
48,688,548 bp from pter
Size:
1,266 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RASE_HUMAN, Q7Z444 (See protein sequence)
Recommended Name: GTPase ERas precursor  
Size: 233 amino acids; 25287 Da
Subunit: Interacts with PIK3CD (By similarity)

Explore the universe of human proteins at neXtProt for ERAS: NX_Q7Z444

Explore proteomics data for ERAS at MOPED


See ERAS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_853510.1  
ENSEMBL proteins: 
 ENSP00000339136  

ERAS Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for ERAS
OriGene Protein Over-expression Lysate for ERAS
OriGene MassSpec for ERAS
OriGene Custom Protein Services for ERAS
GenScript Custom Purified and Recombinant Proteins Services for ERAS
Novus Biologicals ERAS Protein
Novus Biologicals ERAS Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

ERAS Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Cell Signaling Technology (CST) Antibodies for ERAS 
OriGene Antibodies for ERAS
OriGene Custom Antibody Services for ERAS
Novus Biologicals ERAS Antibodies
Abcam antibodies for ERAS
Browse Antibodies at Cloud-Clone Corp.
ThermoFisher Antibodies for ERAS
LSBio Antibodies in human, mouse, rat for ERAS

ERAS Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for ERAS
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for ERAS
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
4 InterPro protein domains:
 IPR005225 Small_GTP-bd_dom
 IPR001806 Small_GTPase
 IPR027417 P-loop_NTPase
 IPR020849 Small_GTPase_Ras

Graphical View of Domain Structure for InterPro Entry Q7Z444

ProtoNet protein and cluster: Q7Z444

2 Blocks protein domains:
IPB001806 Transforming protein P21 RAS signature
IPB003577 Ras small GTPase


UniProtKB/Swiss-Prot: RASE_HUMAN, Q7Z444
Similarity: Belongs to the small GTPase superfamily. Ras family


ERAS for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: RASE_HUMAN, Q7Z444
Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the
tumor-like growth properties of embryonic stem cells (By similarity)
Enzyme regulation: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by
a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003924GTPase activity ----
GO:0005525GTP binding IEA--
     
ERAS for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ERAS
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ERAS

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ERAS
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ERAS

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat ERAS using miScript Target Protectors
4 qRT-PCR Assays for microRNAs that regulate ERAS:
hsa-miR-590-3p hsa-miR-578 hsa-miR-543 hsa-miR-507
SwitchGear 3'UTR luciferase reporter plasmidERAS 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for ERAS
Predesigned siRNA for gene silencing in human, mouse, rat ERAS

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for ERAS

Clone
Products:
     
OriGene clones in human, mouse for ERAS (see all 5)
OriGene ORF clones in mouse, rat for ERAS
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: ERAS (NM_181532)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERAS
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERAS

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for ERAS
Browse ESI BIO Cell Lines and PureStem Progenitors for ERAS 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERAS


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
RASE_HUMAN, Q7Z444: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5
cytosol3
extracellular2
chloroplast1
nucleus1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005886plasma membrane IEA--
GO:0016020membrane ----

ERAS for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for ERAS About                                                                                                See pathways by source

SuperPathContained pathways About
1PI3K / Akt Signaling
PI3K / Akt Signaling

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Cell Signaling Technology (CST) Pathway for ERAS
    PI3K / Akt Signaling



ERAS for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ERAS
Interactions:

    Search GeneGlobe Interaction Network for ERAS

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

Selected Interacting proteins for ERAS (Q7Z4443 ENSP000003391364) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
InteractantInteraction Details
GeneCardExternal ID(s)
PIK3CDO003293, ENSP000003665634I2D: score=1 STRING: ENSP00000366563
PIK3CGP487363, ENSP000003521214I2D: score=1 STRING: ENSP00000352121
PIK3R1P279863, ENSP000002743354I2D: score=1 STRING: ENSP00000274335
RAF1P040493, ENSP000002518494I2D: score=1 STRING: ENSP00000251849
EIF3DENSP000002161904STRING: ENSP00000216190
About this table

Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006184GTP catabolic process IEA--
GO:0007165signal transduction ----
GO:0007264small GTPase mediated signal transduction IEA--
GO:0015031protein transport ----

ERAS for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ERAS (RASE)

1 HMDB Compound for ERAS    About this table
CompoundSynonyms CAS #PubMed Ids
Guanosine triphosphate5'-GTP (see all 10)86-01-1--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for ERAS gene: 
NM_181532.3  

Unigene Cluster for ERAS:

ES cell expressed Ras
Hs.447330
Unigene Representative Sequence: NM_181532
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000338270(uc004dky.1)
Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat ERAS using miScript Target Protectors
4 qRT-PCR Assays for microRNAs that regulate ERAS:
hsa-miR-590-3p hsa-miR-578 hsa-miR-543 hsa-miR-507
SwitchGear 3'UTR luciferase reporter plasmidERAS 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for ERAS
Predesigned siRNA for gene silencing in human, mouse, rat ERAS
Clone
Products:
     
OriGene clones in human, mouse for ERAS (see all 5)
OriGene ORF clones in mouse, rat for ERAS
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: ERAS (NM_181532)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERAS
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERAS
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for ERAS
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ERAS
  QuantiTect SYBR Green Assays in human, mouse, rat ERAS
  QuantiFast Probe-based Assays in human, mouse, rat ERAS

Additional mRNA sequence: 

BC101642.1 BC101644.1 

1 DOTS entry:

DT.100738381 

2 AceView cDNA sequences:

AB093575 NM_181532 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

ERAS expression in normal human tissues (normalized intensities)      ERAS embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCGAGTGTTG
ERAS Expression
About this image


ERAS expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
         20D17
 
 Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
         Epiblast Cells Epiblast
         Epiblast Stem Cell line 5
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Muscle Progenitor Cells Mandibular Arch Muscles
ERAS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ERAS Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.447330
    Custom PCR Arrays for ERAS
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for ERAS
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ERAS
QuantiTect SYBR Green Assays in human, mouse, rat ERAS
QuantiFast Probe-based Assays in human, mouse, rat ERAS
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERAS

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals and fungi.

Orthologs for ERAS gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Eras1 , 5 ES cell-expressed Ras1, 5 78.41(n)1
75.77(a)1
  X (3.58 cM)5
3532831  NM_181548.21  NP_853526.11 
 79242765 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
44(a)
many ↔ many
GL344156.1(49897-86450)
zebrafish
(Danio rerio)
Actinopterygii zgc:555586
zgc:55558
45(a)
many ↔ many
3(16283354-16299952) ENSDARG00000013161
fruit fly
(Drosophila melanogaster)
Insecta Ras85D6
Ras oncogene at 85D
41(a)
1 → many
3R(5336283-5338809)
worm
(Caenorhabditis elegans)
Secernentea let-606
Protein LET-60 (let-60) mRNA, complete cds
43(a)
1 → many
IV(11688227-11691088) WBGene00002335
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAS26
RAS16
GTP-binding protein that regulates the nitrogen st...
GTPase involved in G-protein signaling in the aden...
23(a)
22(a)
many ↔ many
many ↔ many
XIV(439602-440570) YNL098C
XV(515244-516173) YOR101W


ENSEMBL Gene Tree for ERAS (if available)
TreeFam Gene Tree for ERAS (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for ERAS gene
REM12  RALA2  RRAS2  RALB2  RRAD2  NRAS2  REM22  KRAS2  
GEM2  RRAS22  HRAS2  MRAS2  
Selected SIMAP similar genes for ERAS using alignment to 1 protein entry:     RASE_HUMAN(see all similar genes):
HRAS    KRAS    NRAS    DKFZp547A0616    RALA    RAP1B
RAP1A    RAP2B    MRAS    RAP2A    RHEB    RIT2
RAP2C    RRAS    RALB    DIRAS2    RIT1    RHEBL1

ERAS for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for ERAS (see all 72)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1810729841,2
--48683884(+) GGAGTC/TGGATC 1 -- us2k10--------
rs1854853741,2
--48683929(+) ATGATA/CCCAAG 1 -- us2k10--------
rs1903400671,2
--48684065(+) TGGCAA/CGATCT 1 -- us2k10--------
rs1828617811,2
--48684066(+) GGCACC/GATCTC 1 -- us2k10--------
rs1885676801,2
--48684071(+) GATCTC/TGGCTC 1 -- us2k10--------
rs1922063821,2
--48684108(+) AGTGAC/TTCTCC 1 -- us2k10--------
rs1840454991,2
--48684130(+) CCTGAA/GTAGCT 1 -- us2k10--------
rs1877485501,2
C--48684243(+) TGATCC/TGCTGG 1 -- us2k10--------
rs1464636121,2
--48684297(+) CTCCCA/GGGCCA 1 -- us2k10--------
rs1413368431,2
--48684350(+) GCTGCC/TCTCTC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for ERAS (48687283 - 48688548 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for ERAS:    About this table    
Variant IDTypeSubtypePubMed ID
nsv528292CNV Gain19592680
esv32909CNV Gain+Loss17666407

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ERAS
DNA2.0 Custom Variant and Variant Library Synthesis for ERAS

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 300437    OMIM disorders: --

10 diseases for ERAS:    About MalaCards
acquired immunodeficiency syndrome    hypoplastic left heart syndrome    human immunodeficiency virus infectious disease    sarcoma
hiv-1    neuroblastoma    endotheliitis    medulloblastoma
hypertension    esophagitis

4 diseases from the University of Copenhagen DISEASES database for ERAS:
Hypoplastic left heart syndrome     Acquired immunodeficiency syndrome     Heart disease     Hypertension

ERAS for disorders           About GeneDecksing


Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

Export disorders for ERAS gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for ERAS gene, integrated from 10 sources (see all 20):
(articles sorted by number of sources associating them with ERAS)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Role of Eras in promoting tumor-like properties in mouse embryonic stem cells. (PubMed id 12774123)1, 2, 3 Takahashi K.... Yamanaka S. (Nature 2003)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Role of the ERas gene in gastric cancer cells. (PubMed id 23612786)1 Liu Y....Wang H. (Oncol. Rep. 2013)
  4. Functional genomics identifies drivers of medulloblastoma dissemination. (PubMed id 22875024)1 Mumert M....Fults D.W. (Cancer Res. 2012)
  5. Identification of HLA-A*2402-restricted epitope peptide derived from ERas oncogene expressed in human scirrhous gastric cancer. (PubMed id 21205089)1 Iwauchi T....Hirakawa K. (Cancer Sci. 2011)
  6. ERas enhances resistance to CPT-11 in gastric cancer. (PubMed id 21965746)1 Kubota E....Joh T. (Anticancer Res. 2011)
  7. Resistance to chemotherapeutic agents and promotion of transforming activity mediated by embryonic stem cell-expressed Ras (ERas) signal in neuroblastoma cells. (PubMed id 20811723)1 Aoyama M....Asai K. (Int. J. Oncol. 2010)
  8. Role of ES cell-expressed Ras (ERas) in tumorigenicity of gastric cancer. (PubMed id 20566745)1 Kubota E....Joh T. (Am. J. Pathol. 2010)
  9. Detection of I^-catenin, gastrokine-2 and embryonic stem cell expressed ras in gastric cancers. (PubMed id 21151392)1 Zhang F....Yan Z.W. (Int J Clin Exp Pathol 2010)
  10. Epigenetic regulation of the embryonic oncogene ERas in gastric cancer cells. (PubMed id 19787253)1 Yashiro M....Hirakawa K. (Int. J. Oncol. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 3266 HGNC: 5174 AceView: ERAS Ensembl:ENSG00000187682 euGenes: HUgn3266
ECgene: ERAS H-InvDB: ERAS

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for ERAS Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for ERAS gene:
Search GeneIP for patents involving ERAS

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for ERAS   OriGene RNAi products in human, mouse, rat for ERAS  
 Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ERAS  
 OriGene MassSpec something-or-other for ERAS   OriGene clones in human, mouse for ERAS  
 OriGene qSTAR qPCR primer pairs in human, mouse for ERAS   OriGene Purified Protein for ERAS  
 OriGene ORF clones in mouse, rat for ERAS   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for ERAS   OriGene Custom Protein Services for ERAS  

 
 
 Block miRNA regulation of human, mouse, rat ERAS using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ERAS
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ERAS Predesigned siRNA for gene silencing in human, mouse, rat ERAS
 QuantiFast Probe-based Assays in human, mouse, rat ERAS QuantiTect SYBR Green Assays in human, mouse, rat ERAS
 Custom PCR Arrays for ERAS Search Chromatin IP Primers for ERAS
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ERAS  Search GeneGlobe Interaction Network for ERAS
 Regulatory tfbs in ERAS promoter
 GenScript Custom Purified and Recombinant Proteins Services for ERAS GenScript cDNA clones with any tag delivered in your preferred vector for ERAS
 GenScript Custom Assay Services for ERAS GenScript Custom overexpressing Cell Line Services for ERAS
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Antibodies & Assays for ERAS 

 Search Tocris compounds for ERAS (RASE)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 ERAS antibodies
 ERAS proteins
 ERAS lysates
 Antibodies for ERAS
 See all of Abcam's Antibodies, Kits and Proteins for ERAS
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.



 Browse ESI BIO Cell Lines and PureStem Progenitors for ERAS
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERAS
 SwitchGear 3'UTR luciferase reporter plasmids for ERAS
 SwitchGear Promoter luciferase reporter plasmids for ERAS
 ThermoFisher Antibodies for ERAS
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERAS
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ERAS
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ERAS
 LSBio Antibodies in human, mouse, rat for ERAS
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      ERAS gene at Home site.
Version: 3.12.136 22 July 2014
hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4