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Aliases for ERAS Gene

Aliases for ERAS Gene

  • ES Cell Expressed Ras 2 3
  • HRAS2 3 4 6
  • HRASP 3 4 6
  • V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog Pseudogene 2 3
  • Embryonic Stem Cell-Expressed Ras 3 4
  • E-Ras 3 4
  • V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog 2 3
  • Small GTPase Protein E-Ras 3
  • GTPase ERas 3

External Ids for ERAS Gene

Previous HGNC Symbols for ERAS Gene

  • HRAS2
  • HRASP

Previous GeneCards Identifiers for ERAS Gene

  • GC0XU900451
  • GC0XP047733
  • GC0XP048443
  • GC0XP048572
  • GC0XP048687
  • GC0XP046346

Summaries for ERAS Gene

Entrez Gene Summary for ERAS Gene

  • This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance. [provided by RefSeq, Dec 2012]

GeneCards Summary for ERAS Gene

ERAS (ES Cell Expressed Ras) is a Protein Coding gene. Diseases associated with ERAS include hypoplastic left heart syndrome and acquired immunodeficiency syndrome. Among its related pathways are PI3K / Akt Signaling. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is HRAS.

UniProtKB/Swiss-Prot for ERAS Gene

  • Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERAS Gene

Genomics for ERAS Gene

Regulatory Elements for ERAS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ERAS Gene

Start:
48,826,513 bp from pter
End:
48,830,138 bp from pter
Size:
3,626 bases
Orientation:
Plus strand

Genomic View for ERAS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ERAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERAS Gene

Proteins for ERAS Gene

  • Protein details for ERAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z444-RASE_HUMAN
    Recommended name:
    GTPase ERas
    Protein Accession:
    Q7Z444
    Secondary Accessions:

    Protein attributes for ERAS Gene

    Size:
    233 amino acids
    Molecular mass:
    25287 Da
    Quaternary structure:
    • Interacts with PIK3CD.

neXtProt entry for ERAS Gene

Proteomics data for ERAS Gene at MOPED

Post-translational modifications for ERAS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ERAS Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ERAS (ERas)

No data available for DME Specific Peptides for ERAS Gene

Domains for ERAS Gene

Suggested Antigen Peptide Sequences for ERAS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z444

UniProtKB/Swiss-Prot:

RASE_HUMAN :
  • Q7Z444
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with ERAS: view

No data available for Gene Families for ERAS Gene

Function for ERAS Gene

Molecular function for ERAS Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP)
UniProtKB/Swiss-Prot Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells (By similarity).

Gene Ontology (GO) - Molecular Function for ERAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ERAS: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ERAS

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ERAS Gene

Localization for ERAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERAS Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ERAS Gene COMPARTMENTS Subcellular localization image for ERAS gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 2
chloroplast 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ERAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with ERAS: view

Pathways for ERAS Gene

SuperPathways for ERAS Gene

Superpath Contained pathways
1 PI3K / Akt Signaling
genes like me logo Genes that share pathways with ERAS: view

Pathways by source for ERAS Gene

1 Cell Signaling Technology pathway for ERAS Gene

Gene Ontology (GO) - Biological Process for ERAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with ERAS: view

Compounds for ERAS Gene

(1) HMDB Compounds for ERAS Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with ERAS: view

Transcripts for ERAS Gene

mRNA/cDNA for ERAS Gene

(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ERAS Gene

ES cell expressed Ras:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ERAS

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ERAS

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERAS Gene

No ASD Table

Relevant External Links for ERAS Gene

GeneLoc Exon Structure for
ERAS
ECgene alternative splicing isoforms for
ERAS

Expression for ERAS Gene

mRNA expression in normal human tissues for ERAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ERAS Gene

This gene is overexpressed in Brain - Hypothalamus (5.8), Brain - Cerebellum (5.3), and Brain - Cerebellar Hemisphere (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ERAS Gene

SOURCE GeneReport for Unigene cluster for ERAS Gene Hs.447330

genes like me logo Genes that share expressions with ERAS: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ERAS Gene

Orthologs for ERAS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ERAS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ERAS 35
  • 84.12 (n)
  • 77.68 (a)
ERAS 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ERAS 35
  • 83.4 (n)
  • 79.4 (a)
ERAS 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eras 35
  • 78.41 (n)
  • 75.77 (a)
Eras 16
Eras 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
OneToMany
-- 36
  • 38 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Eras 35
  • 77.68 (n)
  • 73.13 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:55558 36
  • 45 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Ras85D 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea let-60 36
  • 43 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAS1 36
  • 22 (a)
ManyToMany
RAS2 36
  • 23 (a)
ManyToMany
Species with no ortholog for ERAS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ERAS Gene

ENSEMBL:
Gene Tree for ERAS (if available)
TreeFam:
Gene Tree for ERAS (if available)

Paralogs for ERAS Gene

Paralogs for ERAS Gene

Selected SIMAP similar genes for ERAS Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ERAS: view

Variants for ERAS Gene

Sequence variations from dbSNP and Humsavar for ERAS Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs5906714 -- 48,826,236(+) GAGGC(A/G)CCACA upstream-variant-2KB
rs5906715 -- 48,828,708(+) ttttc(C/T)gggtg intron-variant
rs7053690 -- 48,828,832(+) tcaat(A/T)aagct intron-variant
rs34985470 -- 48,827,505(-) TCCCT(-/G)GGGAA intron-variant
rs60195465 -- 48,826,665(+) CACTC(-/G)GGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERAS Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV Gain+Loss 17666407
nsv528292 CNV Gain 19592680

Relevant External Links for ERAS Gene

HapMap Linkage Disequilibrium report
ERAS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERAS Gene

Disorders for ERAS Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ERAS Gene including...

Search for ERAS Gene in MalaCards »
genes like me logo Genes that share disorders with ERAS: view

No data available for UniProtKB/Swiss-Prot for ERAS Gene

Publications for ERAS Gene

  1. Role of Eras in promoting tumor-like properties in mouse embryonic stem cells. (PMID: 12774123) Takahashi K. … Yamanaka S. (Nature 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Human ERas gene has an upstream premature polyadenylation signal that results in a truncated, noncoding transcript. (PMID: 16081664) Kameda T. … Thomson J.A. (Stem Cells 2005) 3
  4. HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway. (PMID: 16436505) Toschi E. … Ensoli B. (Mol. Biol. Cell 2006) 3
  5. HIV-1 Tat activates dual Nox pathways leading to independent activation of ERK and JNK MAP kinases. (PMID: 17940286) Wu R.F. … Terada L.S. (J. Biol. Chem. 2007) 3

Products for ERAS Gene

  • Addgene plasmids for ERAS

Sources for ERAS Gene

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