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Aliases for ERAS Gene

Aliases for ERAS Gene

  • ES Cell Expressed Ras 2 3 5
  • V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog Pseudogene 2 3
  • Embryonic Stem Cell-Expressed Ras 3 4
  • HRAS2 3 4
  • HRASP 3 4
  • E-Ras 3 4
  • V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog 2 3
  • Small GTPase Protein E-Ras 3

External Ids for ERAS Gene

Previous HGNC Symbols for ERAS Gene

  • HRAS2
  • HRASP

Previous GeneCards Identifiers for ERAS Gene

  • GC0XU900451
  • GC0XP047733
  • GC0XP048443
  • GC0XP048572
  • GC0XP048687
  • GC0XP046346

Summaries for ERAS Gene

Entrez Gene Summary for ERAS Gene

  • This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance. [provided by RefSeq, Dec 2012]

GeneCards Summary for ERAS Gene

ERAS (ES Cell Expressed Ras) is a Protein Coding gene. Diseases associated with ERAS include median neuropathy and intracranial abscess. GO annotations related to this gene include GTP binding. An important paralog of this gene is HRAS.

UniProtKB/Swiss-Prot for ERAS Gene

  • Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERAS Gene

Genomics for ERAS Gene

Regulatory Elements for ERAS Gene

Genomic Location for ERAS Gene

Chromosome:
X
Start:
48,826,513 bp from pter
End:
48,830,138 bp from pter
Size:
3,626 bases
Orientation:
Plus strand

Genomic View for ERAS Gene

Genes around ERAS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERAS Gene

Proteins for ERAS Gene

  • Protein details for ERAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z444-RASE_HUMAN
    Recommended name:
    GTPase ERas
    Protein Accession:
    Q7Z444

    Protein attributes for ERAS Gene

    Size:
    233 amino acids
    Molecular mass:
    25287 Da
    Quaternary structure:
    • Interacts with PIK3CD.

neXtProt entry for ERAS Gene

Proteomics data for ERAS Gene at MOPED

Post-translational modifications for ERAS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ERAS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ERAS Gene

Domains & Families for ERAS Gene

Gene Families for ERAS Gene

Suggested Antigen Peptide Sequences for ERAS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z444

UniProtKB/Swiss-Prot:

RASE_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with ERAS: view

Function for ERAS Gene

Molecular function for ERAS Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
UniProtKB/Swiss-Prot Function:
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells (By similarity).

Phenotypes for ERAS Gene

genes like me logo Genes that share phenotypes with ERAS: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ERAS Gene

Localization for ERAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERAS Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ERAS Gene COMPARTMENTS Subcellular localization image for ERAS gene
Compartment Confidence
cytosol 4
plasma membrane 3
extracellular 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ERAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with ERAS: view

Pathways & Interactions for ERAS Gene

SuperPathways for ERAS Gene

No Data Available

Gene Ontology (GO) - Biological Process for ERAS Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ERAS Gene

Drugs & Compounds for ERAS Gene

(49) Drugs for ERAS Gene - From: ClinicalTrials and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acetaminophen Approved Pharma 864
Bupivacaine Approved, Investigational Pharma Pore Blocker 964
Dexamethasone Approved, Investigational Pharma Agonist 1909
Droperidol Approved Pharma 21
Epinephrine Approved Pharma 834
genes like me logo Genes that share compounds with ERAS: view

Transcripts for ERAS Gene

mRNA/cDNA for ERAS Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ERAS Gene

ES cell expressed Ras:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERAS Gene

No ASD Table

Relevant External Links for ERAS Gene

GeneLoc Exon Structure for
ERAS
ECgene alternative splicing isoforms for
ERAS

Expression for ERAS Gene

mRNA expression in normal human tissues for ERAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ERAS Gene

This gene is overexpressed in Brain - Hypothalamus (x5.8), Brain - Cerebellum (x5.3), and Brain - Cerebellar Hemisphere (x5.1).

Protein differential expression in normal tissues from HIPED for ERAS Gene

This gene is overexpressed in NK cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ERAS Gene



SOURCE GeneReport for Unigene cluster for ERAS Gene Hs.447330

genes like me logo Genes that share expression patterns with ERAS: view

Protein tissue co-expression partners for ERAS Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ERAS Gene

Orthologs for ERAS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ERAS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ERAS 36
  • 77 (a)
OneToOne
ERAS 35
  • 84.12 (n)
  • 77.68 (a)
dog
(Canis familiaris)
Mammalia ERAS 35
  • 83.4 (n)
  • 79.4 (a)
ERAS 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eras 16
Eras 36
  • 76 (a)
OneToOne
Eras 35
  • 78.41 (n)
  • 75.77 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
OneToMany
-- 36
  • 38 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Eras 35
  • 77.68 (n)
  • 73.13 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:55558 36
  • 45 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Ras85D 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea let-60 36
  • 43 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAS1 36
  • 22 (a)
ManyToMany
RAS2 36
  • 23 (a)
ManyToMany
Species with no ortholog for ERAS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ERAS Gene

ENSEMBL:
Gene Tree for ERAS (if available)
TreeFam:
Gene Tree for ERAS (if available)

Paralogs for ERAS Gene

Paralogs for ERAS Gene

(20) SIMAP similar genes for ERAS Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ERAS: view

Variants for ERAS Gene

Sequence variations from dbSNP and Humsavar for ERAS Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs5906715 -- 48,828,708(+) ttttc(C/T)gggtg intron-variant
rs7053690 -- 48,828,832(+) tcaat(A/T)aagct intron-variant
rs34985470 -- 48,827,505(-) TCCCT(-/G)GGGAA intron-variant
rs67645424 -- 48,826,666(+) CTCGG(C/G)CCGGC intron-variant
rs61757377 -- 48,829,570(+) CTCGT(G/T)GGCAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ERAS Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV Gain+Loss 17666407
nsv528292 CNV Gain 19592680

Variation tolerance for ERAS Gene

Residual Variation Intolerance Score: 45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ERAS Gene

HapMap Linkage Disequilibrium report
ERAS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERAS Gene

Disorders for ERAS Gene

MalaCards: The human disease database

(4) MalaCards diseases for ERAS Gene - From: DISEASES

Disorder Aliases PubMed IDs
median neuropathy
intracranial abscess
bladder diverticulum
  • diverticulum - bladder
glanders
  • farcy pipes
- elite association - COSMIC cancer census association via MalaCards
Search ERAS in MalaCards View complete list of genes associated with diseases

Relevant External Links for ERAS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ERAS
genes like me logo Genes that share disorders with ERAS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ERAS Gene

Publications for ERAS Gene

  1. Role of Eras in promoting tumor-like properties in mouse embryonic stem cells. (PMID: 12774123) Takahashi K. … Yamanaka S. (Nature 2003) 2 3 4 67
  2. The Function of Embryonic Stem Cell-expressed RAS (E-RAS), a Unique RAS Family Member, Correlates with Its Additional Motifs and Its Structural Properties. (PMID: 25940089) Nakhaei-Rad S. … Ahmadian M.R. (J. Biol. Chem. 2015) 3
  3. BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model. (PMID: 25624498) Perna D. … Adams D.J. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3
  4. Role of the ERas gene in gastric cancer cells. (PMID: 23612786) Liu Y. … Wang H. (Oncol. Rep. 2013) 3
  5. Functional genomics identifies drivers of medulloblastoma dissemination. (PMID: 22875024) Mumert M. … Fults D.W. (Cancer Res. 2012) 3

Products for ERAS Gene

Sources for ERAS Gene

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