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Aliases for ERAS Gene

Aliases for ERAS Gene

  • ES Cell Expressed Ras 2 3 5
  • V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog Pseudogene 2 3
  • Embryonic Stem Cell-Expressed Ras 3 4
  • HRAS2 3 4
  • HRASP 3 4
  • E-Ras 3 4
  • V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog 2 3
  • Small GTPase Protein E-Ras 3
  • GTPase ERas 3

External Ids for ERAS Gene

Previous HGNC Symbols for ERAS Gene

  • HRAS2
  • HRASP

Previous GeneCards Identifiers for ERAS Gene

  • GC0XU900451
  • GC0XP047733
  • GC0XP048443
  • GC0XP048572
  • GC0XP048687
  • GC0XP046346

Summaries for ERAS Gene

Entrez Gene Summary for ERAS Gene

  • This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance. [provided by RefSeq, Dec 2012]

GeneCards Summary for ERAS Gene

ERAS (ES Cell Expressed Ras) is a Protein Coding gene. Diseases associated with ERAS include Orbital Tenonitis and Median Neuropathy. Among its related pathways are PI3K / Akt Signaling. GO annotations related to this gene include GTP binding. An important paralog of this gene is NRAS.

UniProtKB/Swiss-Prot for ERAS Gene

  • Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERAS Gene

Genomics for ERAS Gene

Regulatory Elements for ERAS Gene

Enhancers for ERAS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG048799 1.4 ENCODE dbSUPER 13.9 -25.0 -25004 4.0 HDGF PKNOX1 CREB3L1 ARNT SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 PRICKLE3 ERAS PLP2 ENSG00000204620 HDAC6 PIR34696
GH0XG048890 1.2 Ensembl ENCODE 11.6 +64.9 64902 2.0 AGO1 ARID4B SIN3A ZNF48 GLIS2 SP3 REST ZNF579 SMARCA4 GLIS1 SLC35A2 PIM2 ERAS GLOD5 GRIPAP1 PQBP1 PCSK1N
GH0XG048867 1 ENCODE 12.3 +41.5 41544 0.3 PKNOX1 FOXA2 ATF1 ARNT BRCA1 TCF12 FOS REST ZNF592 MEF2D ERAS ENSG00000270012 GLOD5 ZNF182 ZNF630 ENSG00000204620 PQBP1 PCSK1N
GH0XG048776 0.7 dbSUPER 12.1 -49.4 -49414 1.3 PKNOX1 L3MBTL2 NRF1 MAFG DPF2 ZNF592 FOSL1 JUND ZNF316 IKZF1 ERAS HDAC6 RNU6-29P GC0XM048777 GATA1
GH0XG048834 1 ENCODE 0.4 +8.7 8668 2.3 ZNF133 ARID4B GLI4 ZNF2 KLF7 SP3 SP5 YY2 MIER2 REST ZNF81 ENSG00000204620 ENSG00000270012 ZNF182 CCDC120 PCSK1N PRAF2 SYP GRIPAP1 ERAS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ERAS on UCSC Golden Path with GeneCards custom track

Genomic Location for ERAS Gene

Chromosome:
X
Start:
48,826,513 bp from pter
End:
48,830,138 bp from pter
Size:
3,626 bases
Orientation:
Plus strand

Genomic View for ERAS Gene

Genes around ERAS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERAS Gene

Proteins for ERAS Gene

  • Protein details for ERAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z444-RASE_HUMAN
    Recommended name:
    GTPase ERas
    Protein Accession:
    Q7Z444

    Protein attributes for ERAS Gene

    Size:
    233 amino acids
    Molecular mass:
    25287 Da
    Quaternary structure:
    • Interacts with PIK3CD.

neXtProt entry for ERAS Gene

Post-translational modifications for ERAS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ERAS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ERAS Gene

Domains & Families for ERAS Gene

Gene Families for ERAS Gene

Suggested Antigen Peptide Sequences for ERAS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z444

UniProtKB/Swiss-Prot:

RASE_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with ERAS: view

Function for ERAS Gene

Molecular function for ERAS Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
UniProtKB/Swiss-Prot Function:
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells (By similarity).

Gene Ontology (GO) - Molecular Function for ERAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ERAS: view
genes like me logo Genes that share phenotypes with ERAS: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ERAS

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ERAS

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ERAS Gene

Localization for ERAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERAS Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERAS gene
Compartment Confidence
cytosol 4
plasma membrane 3
extracellular 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ERAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ERAS: view

Pathways & Interactions for ERAS Gene

SuperPathway Contained pathways
1 PI3K / Akt Signaling
genes like me logo Genes that share pathways with ERAS: view

Pathways by source for ERAS Gene

1 Cell Signaling Technology pathway for ERAS Gene

Gene Ontology (GO) - Biological Process for ERAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with ERAS: view

No data available for SIGNOR curated interactions for ERAS Gene

Drugs & Compounds for ERAS Gene

(53) Drugs for ERAS Gene - From: ClinicalTrials and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acetaminophen Approved Pharma Cyclooxygenase inhibitor; may be selective for COX-3 1026
Bupivacaine Approved, Investigational Pharma Pore Blocker 1233
Cyclizine Approved Pharma 4
Dexamethasone Approved, Investigational, Vet_approved Pharma Agonist 2171
Droperidol Approved, Vet_approved Pharma 23
genes like me logo Genes that share compounds with ERAS: view

Transcripts for ERAS Gene

mRNA/cDNA for ERAS Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ERAS Gene

ES cell expressed Ras:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ERAS

Alternative Splicing Database (ASD) splice patterns (SP) for ERAS Gene

No ASD Table

Relevant External Links for ERAS Gene

GeneLoc Exon Structure for
ERAS
ECgene alternative splicing isoforms for
ERAS

Expression for ERAS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ERAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ERAS Gene

This gene is overexpressed in Brain - Hypothalamus (x5.8), Brain - Cerebellum (x5.3), and Brain - Cerebellar Hemisphere (x5.1).

Protein differential expression in normal tissues from HIPED for ERAS Gene

This gene is overexpressed in NK cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ERAS Gene



Protein tissue co-expression partners for ERAS Gene

NURSA nuclear receptor signaling pathways regulating expression of ERAS Gene:

ERAS

SOURCE GeneReport for Unigene cluster for ERAS Gene:

Hs.447330

Evidence on tissue expression from TISSUES for ERAS Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ERAS: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERAS Gene

Orthologs for ERAS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ERAS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ERAS 34 35
  • 84.12 (n)
dog
(Canis familiaris)
Mammalia ERAS 34 35
  • 83.4 (n)
mouse
(Mus musculus)
Mammalia Eras 34 16 35
  • 78.41 (n)
rat
(Rattus norvegicus)
Mammalia LOC100911243 34
  • 77.68 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 38 (a)
OneToMany
-- 35
  • 37 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 44 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:55558 35
  • 45 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Ras85D 35
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea let-60 35
  • 43 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAS2 35
  • 23 (a)
ManyToMany
RAS1 35
  • 22 (a)
ManyToMany
Species where no ortholog for ERAS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ERAS Gene

ENSEMBL:
Gene Tree for ERAS (if available)
TreeFam:
Gene Tree for ERAS (if available)

Paralogs for ERAS Gene

Paralogs for ERAS Gene

(20) SIMAP similar genes for ERAS Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ERAS: view

Variants for ERAS Gene

Sequence variations from dbSNP and Humsavar for ERAS Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs398122390 Pathogenic 48,824,894(+) ATATC(A/T)TGAGG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000010574 -- 48,827,180(+) AGCTG(A/C)GCTCC intron-variant
rs1002558535 -- 48,824,625(+) AATAC(A/G)GTCCC nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1003481965 -- 48,826,803(+) CTTCC(A/G)CACTC intron-variant
rs1004120579 -- 48,826,450(+) GCATG(C/T)CCACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ERAS Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV gain+loss 17666407
esv3576862 CNV gain 25503493
nsv528292 CNV gain 19592680

Variation tolerance for ERAS Gene

Residual Variation Intolerance Score: 45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ERAS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ERAS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERAS Gene

Disorders for ERAS Gene

MalaCards: The human disease database

(4) MalaCards diseases for ERAS Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
orbital tenonitis
  • tenonitis
median neuropathy
intracranial abscess
pseudohypoaldosteronism type i, autosomal dominant
  • pseudohypoaldosteronism, type i, autosomal dominant
- elite association - COSMIC cancer census association via MalaCards
Search ERAS in MalaCards View complete list of genes associated with diseases

Relevant External Links for ERAS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ERAS
genes like me logo Genes that share disorders with ERAS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ERAS Gene

Publications for ERAS Gene

  1. Role of Eras in promoting tumor-like properties in mouse embryonic stem cells. (PMID: 12774123) Takahashi K. … Yamanaka S. (Nature 2003) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model. (PMID: 25624498) Perna D. … Adams D.J. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3 64
  4. The Function of Embryonic Stem Cell-expressed RAS (E-RAS), a Unique RAS Family Member, Correlates with Its Additional Motifs and Its Structural Properties. (PMID: 25940089) Nakhaei-Rad S. … Ahmadian M.R. (J. Biol. Chem. 2015) 3 64
  5. Role of the ERas gene in gastric cancer cells. (PMID: 23612786) Liu Y. … Wang H. (Oncol. Rep. 2013) 3 64

Products for ERAS Gene

  • Addgene plasmids for ERAS

Sources for ERAS Gene

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