Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ERAP2 Gene

Aliases for ERAP2 Gene

  • Endoplasmic Reticulum Aminopeptidase 2 2 3
  • Leukocyte-Derived Arginine Aminopeptidase 2 3 4
  • LRAP 3 4 6
  • L-RAP 3 4
  • EC 3.4.11.3 63
  • EC 3.4.11.- 4
  • EC 3.4.11 63

External Ids for ERAP2 Gene

Previous GeneCards Identifiers for ERAP2 Gene

  • GC05P096238
  • GC05P091401
  • GC05P096211

Summaries for ERAP2 Gene

Entrez Gene Summary for ERAP2 Gene

  • Aminopeptidases hydrolyze N-terminal amino acids of proteins or peptide substrates. Major histocompatibility complex (MHC) class I molecules rely on aminopeptidases such as ERAP1 (MIM 606832) and LRAP to trim precursors to antigenic peptides in the endoplasmic reticulum (ER) following cleavage in the cytoplasm by tripeptidyl peptidase II (TPP2; MIM 190470) (Tanioka et al., 2003 [PubMed 12799365]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ERAP2 Gene

ERAP2 (Endoplasmic Reticulum Aminopeptidase 2) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include metallopeptidase activity and aminopeptidase activity. An important paralog of this gene is ERAP1.

UniProtKB/Swiss-Prot for ERAP2 Gene

  • Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERAP2 Gene

Genomics for ERAP2 Gene

Regulatory Elements for ERAP2 Gene

Genomic Location for ERAP2 Gene

Start:
96,875,939 bp from pter
End:
96,919,716 bp from pter
Size:
43,778 bases
Orientation:
Plus strand

Genomic View for ERAP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ERAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERAP2 Gene

Proteins for ERAP2 Gene

  • Protein details for ERAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P179-ERAP2_HUMAN
    Recommended name:
    Endoplasmic reticulum aminopeptidase 2
    Protein Accession:
    Q6P179
    Secondary Accessions:
    • Q7Z5K1
    • Q8TD32
    • Q8WVJ4
    • Q9HBX2

    Protein attributes for ERAP2 Gene

    Size:
    960 amino acids
    Molecular mass:
    110462 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Heterodimer with ERAP1.
    Miscellaneous:
    • Defects in the expression of this gene may cause improper antigen processing, possibly leading to favor tumor escape from the immune surveillance

    Three dimensional structures from OCA and Proteopedia for ERAP2 Gene

    Alternative splice isoforms for ERAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERAP2 Gene

Proteomics data for ERAP2 Gene at MOPED

Selected DME Specific Peptides for ERAP2 Gene

Post-translational modifications for ERAP2 Gene

Other Protein References for ERAP2 Gene

Antibody Products

  • R&D Systems Antibodies for ERAP2 (Aminopeptidase LRAP/ERAP2)
  • Santa Cruz Biotechnology (SCBT) Antibodies for ERAP2

Domains for ERAP2 Gene

Gene Families for ERAP2 Gene

Protein Domains for ERAP2 Gene

Suggested Antigen Peptide Sequences for ERAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P179

UniProtKB/Swiss-Prot:

ERAP2_HUMAN :
  • Q6P179
Family:
  • Belongs to the peptidase M1 family.
genes like me logo Genes that share domains with ERAP2: view

Function for ERAP2 Gene

Molecular function for ERAP2 Gene

UniProtKB/Swiss-Prot Function: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.
UniProtKB/Swiss-Prot Induction: By IFNG/IFN-gamma.

Enzyme Numbers (IUBMB) for ERAP2 Gene

Gene Ontology (GO) - Molecular Function for ERAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity IDA 12799365
GO:0008237 metallopeptidase activity IDA 12799365
GO:0008270 zinc ion binding TAS 12799365
genes like me logo Genes that share ontologies with ERAP2: view
genes like me logo Genes that share phenotypes with ERAP2: view

Animal Model Products

CRISPR Products

miRNA for ERAP2 Gene

miRTarBase miRNAs that target ERAP2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ERAP2 Gene

Localization for ERAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERAP2 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ERAP2 Gene COMPARTMENTS Subcellular localization image for ERAP2 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 3
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ERAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen TAS 15691326
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ERAP2: view

Pathways for ERAP2 Gene

genes like me logo Genes that share pathways with ERAP2: view

Interacting Proteins for ERAP2 Gene

Gene Ontology (GO) - Biological Process for ERAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0006508 proteolysis IEA --
GO:0008217 regulation of blood pressure TAS 12799365
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I TAS 15691326
genes like me logo Genes that share ontologies with ERAP2: view

Compounds for ERAP2 Gene

(4) Novoseek inferred chemical compound relationships for ERAP2 Gene

Compound -log(P) Hits PubMed IDs
hydroxyapatite 56.2 4
leucine 41.1 4
arginine 36.9 8
proline 25.2 1
genes like me logo Genes that share compounds with ERAP2: view

Transcripts for ERAP2 Gene

Unigene Clusters for ERAP2 Gene

Endoplasmic reticulum aminopeptidase 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ERAP2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ERAP2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERAP2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^
SP1: - - - -
SP2: -
SP3: - -
SP4: - -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10: - - - -
SP11: -
SP12:
SP13:

ExUns: 16 ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8: -
SP9: - -
SP10:
SP11:
SP12:
SP13:

Relevant External Links for ERAP2 Gene

GeneLoc Exon Structure for
ERAP2
ECgene alternative splicing isoforms for
ERAP2

Expression for ERAP2 Gene

mRNA expression in normal human tissues for ERAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ERAP2 Gene

SOURCE GeneReport for Unigene cluster for ERAP2 Gene Hs.482910

mRNA Expression by UniProt/SwissProt for ERAP2 Gene

Q6P179-ERAP2_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in spleen and leukocytes.
genes like me logo Genes that share expressions with ERAP2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ERAP2 Gene

Orthologs for ERAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ERAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ERAP2 35
  • 99.55 (n)
  • 99.37 (a)
ERAP2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ERAP2 35
  • 86.5 (n)
  • 82.69 (a)
ERAP2 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ERAP2 35
  • 86.24 (n)
  • 81.93 (a)
ERAP2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ERAP2 36
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii erap2 35
  • 60.24 (n)
  • 58.81 (a)
erap2 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4467 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_F49B2.6 35
  • 45.13 (n)
  • 32.25 (a)
F49B2.6 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for ERAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ERAP2 Gene

ENSEMBL:
Gene Tree for ERAP2 (if available)
TreeFam:
Gene Tree for ERAP2 (if available)

Paralogs for ERAP2 Gene

Paralogs for ERAP2 Gene

Selected SIMAP similar genes for ERAP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ERAP2: view

Variants for ERAP2 Gene

Sequence variations from dbSNP and Humsavar for ERAP2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs171647 -- 96,901,709(+) TCTAG(C/T)TTACC intron-variant
rs187265 -- 96,901,410(+) CCAAG(C/G)CTTGT intron-variant
rs193993 -- 96,899,168(+) ACTGA(C/T)ACTAA intron-variant
rs251339 -- 96,899,334(+) AACTC(C/T)CTTCT intron-variant
rs251340 -- 96,900,708(+) GTCTC(A/G)CTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERAP2 Gene

Variant ID Type Subtype PubMed ID
nsv516293 CNV Gain+Loss 19592680
esv259416 OTHER Complex 20981092
esv259714 OTHER Complex 20981092
esv2658182 CNV Deletion 23128226
nsv823147 CNV Loss 20364138

Relevant External Links for ERAP2 Gene

HapMap Linkage Disequilibrium report
ERAP2
Human Gene Mutation Database (HGMD)
ERAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERAP2 Gene

Disorders for ERAP2 Gene

(1) Novoseek inferred disease relationships for ERAP2 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 3

Relevant External Links for ERAP2

Genetic Association Database (GAD)
ERAP2
Human Genome Epidemiology (HuGE) Navigator
ERAP2
genes like me logo Genes that share disorders with ERAP2: view

No data available for UniProtKB/Swiss-Prot for ERAP2 Gene

Publications for ERAP2 Gene

  1. Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases. (PMID: 12799365) Tanioka T. … Tsujimoto M. (J. Biol. Chem. 2003) 2 3 4 23
  2. Expression of endoplasmic reticulum aminopeptidases in EBV-B cell lines from healthy donors and in leukemia/lymphoma, carcinoma, and melanoma cell lines. (PMID: 16585582) Fruci D. … Giacomini P. (J. Immunol. 2006) 3 4 23
  3. Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis. (PMID: 19433412) Tsui F.W. … Inman R.D. (Ann. Rheum. Dis. 2010) 3 23 48
  4. The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations. (PMID: 19578876) Johnson M.P. … Moses E.K. (Hum. Genet. 2009) 3 23 48
  5. Regulation of the human leukocyte-derived arginine aminopeptidase/endoplasmic reticulum-aminopeptidase 2 gene by interferon-gamma. (PMID: 15691326) Tanioka T. … Tsujimoto M. (FEBS J. 2005) 3 4 23

Products for ERAP2 Gene

Sources for ERAP2 Gene

Back to Top

Content