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Aliases for ERAP2 Gene

Aliases for ERAP2 Gene

  • Endoplasmic Reticulum Aminopeptidase 2 2 3 5
  • Leukocyte-Derived Arginine Aminopeptidase 2 3 4
  • L-RAP 3 4
  • LRAP 3 4
  • EC 3.4.11.3 61
  • EC 3.4.11.- 4
  • EC 3.4.11 61

External Ids for ERAP2 Gene

Previous GeneCards Identifiers for ERAP2 Gene

  • GC05P096238
  • GC05P091401
  • GC05P096211

Summaries for ERAP2 Gene

Entrez Gene Summary for ERAP2 Gene

  • This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic epitopes for presentation by major histocompatibility complex (MHC) class I molecules. Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia. This gene is located adjacent to a closely related aminopeptidase gene on chromosome 5. [provided by RefSeq, Jul 2016]

GeneCards Summary for ERAP2 Gene

ERAP2 (Endoplasmic Reticulum Aminopeptidase 2) is a Protein Coding gene. Diseases associated with ERAP2 include Spondylitis and Birdshot Chorioretinopathy. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include metallopeptidase activity and aminopeptidase activity. An important paralog of this gene is ERAP1.

UniProtKB/Swiss-Prot for ERAP2 Gene

  • Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERAP2 Gene

Genomics for ERAP2 Gene

Regulatory Elements for ERAP2 Gene

Enhancers for ERAP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F096932 0.2 ENCODE 113.2 +58.7 58679 6.6 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ERAP2 RIOK2 ERAP1 ENSG00000251054 ENSG00000250955 LOC391813 ENSG00000248734 LNPEP
GH05F096894 0.6 ENCODE 103.3 +20.2 20154 2.9 TBP CTCF PKNOX1 EBF1 RAD21 CBX5 EED ETV6 CREM HOMEZ ERAP2 ENSG00000247121 LNPEP RPS20P16 ERAP1 ENSG00000248734
GH05F096960 0.6 ENCODE 103.2 +86.2 86246 3.8 PKNOX1 MLX ZFP64 SIN3A ARID4B DMAP1 FEZF1 YY1 CBX5 FOS ERAP2 LNPEP ENSG00000247121 ERAP1 CAST ENSG00000200884 GC05M096963 RPS20P16
GH05F096941 0.5 Ensembl 102.9 +64.9 64862 0.4 ERAP2 LOC101929747 RPS20P16
GH05F096952 0.7 Ensembl ENCODE 102.8 +77.2 77162 1.8 ELF3 SOX13 CEBPG ZNF644 YY1 RARA HOMEZ THAP11 MIXL1 GATAD2A ERAP2 ENSG00000200884 GC05M096963 RPS20P16
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ERAP2 on UCSC Golden Path with GeneCards custom track

Promoters for ERAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001286005 761 1801 HDGF TBP HDAC1 PKNOX1 TBL1XR1 SIN3A ARID4B ZBTB40 GATA2 ZNF366

Genomic Location for ERAP2 Gene

Chromosome:
5
Start:
96,875,939 bp from pter
End:
96,919,716 bp from pter
Size:
43,778 bases
Orientation:
Plus strand

Genomic View for ERAP2 Gene

Genes around ERAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERAP2 Gene

Proteins for ERAP2 Gene

  • Protein details for ERAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P179-ERAP2_HUMAN
    Recommended name:
    Endoplasmic reticulum aminopeptidase 2
    Protein Accession:
    Q6P179
    Secondary Accessions:
    • Q7Z5K1
    • Q8TD32
    • Q8WVJ4
    • Q9HBX2

    Protein attributes for ERAP2 Gene

    Size:
    960 amino acids
    Molecular mass:
    110462 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Heterodimer with ERAP1.
    Miscellaneous:
    • Defects in the expression of this gene may cause improper antigen processing, possibly leading to favor tumor escape from the immune surveillance.

    Three dimensional structures from OCA and Proteopedia for ERAP2 Gene

    Alternative splice isoforms for ERAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERAP2 Gene

Selected DME Specific Peptides for ERAP2 Gene

Post-translational modifications for ERAP2 Gene

Antibody Products

  • R&D Systems Antibodies for ERAP2 (Aminopeptidase LRAP/ERAP2)
  • Abcam antibodies for ERAP2
  • Cloud-Clone Corp. Antibodies for ERAP2

Domains & Families for ERAP2 Gene

Gene Families for ERAP2 Gene

Protein Domains for ERAP2 Gene

Suggested Antigen Peptide Sequences for ERAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P179

UniProtKB/Swiss-Prot:

ERAP2_HUMAN :
  • Belongs to the peptidase M1 family.
Family:
  • Belongs to the peptidase M1 family.
genes like me logo Genes that share domains with ERAP2: view

Function for ERAP2 Gene

Molecular function for ERAP2 Gene

UniProtKB/Swiss-Prot Function:
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma.

Enzyme Numbers (IUBMB) for ERAP2 Gene

Gene Ontology (GO) - Molecular Function for ERAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity EXP 12436109
GO:0004177 aminopeptidase activity IDA 12799365
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA,IDA 12799365
GO:0008270 zinc ion binding IEA,TAS 12799365
genes like me logo Genes that share ontologies with ERAP2: view
genes like me logo Genes that share phenotypes with ERAP2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ERAP2 Gene

Localization for ERAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERAP2 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ERAP2 Gene COMPARTMENTS Subcellular localization image for ERAP2 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 4
plasma membrane 3
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ERAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen TAS 15691326
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ERAP2: view

Pathways & Interactions for ERAP2 Gene

genes like me logo Genes that share pathways with ERAP2: view

Interacting Proteins for ERAP2 Gene

Gene Ontology (GO) - Biological Process for ERAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0006508 proteolysis IEA --
GO:0008217 regulation of blood pressure TAS 12799365
genes like me logo Genes that share ontologies with ERAP2: view

No data available for SIGNOR curated interactions for ERAP2 Gene

Drugs & Compounds for ERAP2 Gene

(3) Drugs for ERAP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ERAP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ERAP2: view

Transcripts for ERAP2 Gene

Unigene Clusters for ERAP2 Gene

Endoplasmic reticulum aminopeptidase 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERAP2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^
SP1: - - - -
SP2: -
SP3: - -
SP4: - -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10: - - - -
SP11: -
SP12:
SP13:

ExUns: 16 ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8: -
SP9: - -
SP10:
SP11:
SP12:
SP13:

Relevant External Links for ERAP2 Gene

GeneLoc Exon Structure for
ERAP2
ECgene alternative splicing isoforms for
ERAP2

Expression for ERAP2 Gene

mRNA expression in normal human tissues for ERAP2 Gene

Protein differential expression in normal tissues from HIPED for ERAP2 Gene

This gene is overexpressed in Ovary (12.8), Lymph node (11.4), and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ERAP2 Gene



NURSA nuclear receptor signaling pathways regulating expression of ERAP2 Gene:

ERAP2

SOURCE GeneReport for Unigene cluster for ERAP2 Gene:

Hs.482910

mRNA Expression by UniProt/SwissProt for ERAP2 Gene:

Q6P179-ERAP2_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in spleen and leukocytes.
genes like me logo Genes that share expression patterns with ERAP2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ERAP2 Gene

Orthologs for ERAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ERAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ERAP2 34 35
  • 99.55 (n)
cow
(Bos Taurus)
Mammalia ERAP2 34 35
  • 86.5 (n)
dog
(Canis familiaris)
Mammalia ERAP2 34 35
  • 86.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ERAP2 35
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii erap2 34 35
  • 60.24 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4467 35
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_F49B2.6 34
  • 45.13 (n)
F49B2.6 35
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for ERAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ERAP2 Gene

ENSEMBL:
Gene Tree for ERAP2 (if available)
TreeFam:
Gene Tree for ERAP2 (if available)

Paralogs for ERAP2 Gene

Paralogs for ERAP2 Gene

(9) SIMAP similar genes for ERAP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ERAP2: view

Variants for ERAP2 Gene

Sequence variations from dbSNP and Humsavar for ERAP2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs34261036 Benign 96,895,352(+) AGAGC(G/T)GCAAT intron-variant, nc-transcript-variant, reference, missense
rs1019503 -- 96,919,113(+) AGGAA(A/G)ACTTG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10434708 -- 96,889,818(+) TTTCC(A/T)TTAAA intron-variant
rs10434709 -- 96,890,070(+) ATCAT(C/T)TGGTT intron-variant
rs10434710 -- 96,890,434(+) CTCAC(C/T)TCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERAP2 Gene

Variant ID Type Subtype PubMed ID
dgv3349e59 CNV tandem duplication 20981092
esv2658182 CNV deletion 23128226
esv3379222 CNV duplication 20981092
esv3605868 CNV loss 21293372
nsv1021263 CNV loss 25217958
nsv1028741 CNV gain 25217958
nsv1119530 CNV insertion 24896259
nsv1142441 CNV tandem duplication 24896259
nsv516293 CNV gain+loss 19592680
nsv598962 CNV gain 21841781
nsv598963 CNV gain 21841781
nsv823147 CNV loss 20364138

Variation tolerance for ERAP2 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.86; 74.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ERAP2 Gene

Human Gene Mutation Database (HGMD)
ERAP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ERAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERAP2 Gene

Disorders for ERAP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ERAP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
spondylitis
birdshot chorioretinopathy
  • birdshot chorioretinitis
- elite association - COSMIC cancer census association via MalaCards
Search ERAP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ERAP2

Genetic Association Database (GAD)
ERAP2
Human Genome Epidemiology (HuGE) Navigator
ERAP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ERAP2
genes like me logo Genes that share disorders with ERAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ERAP2 Gene

Publications for ERAP2 Gene

  1. Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases. (PMID: 12799365) Tanioka T. … Tsujimoto M. (J. Biol. Chem. 2003) 2 3 4 22 64
  2. Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis. (PMID: 19433412) Tsui F.W. … Inman R.D. (Ann. Rheum. Dis. 2010) 3 22 46 64
  3. The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations. (PMID: 19578876) Johnson M.P. … Moses E.K. (Hum. Genet. 2009) 3 22 46 64
  4. Expression of endoplasmic reticulum aminopeptidases in EBV-B cell lines from healthy donors and in leukemia/lymphoma, carcinoma, and melanoma cell lines. (PMID: 16585582) Fruci D. … Giacomini P. (J. Immunol. 2006) 3 4 22 64
  5. Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum. (PMID: 15908954) Saveanu L. … van Endert P.M. (Nat. Immunol. 2005) 2 3 4 64

Products for ERAP2 Gene

Sources for ERAP2 Gene

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