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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ERAP2 Gene

protein-coding GIFtS: 54
GCID: GC05P096238

endoplasmic reticulum aminopeptidase 2

Explore 10 diseases affiliated with
ERAP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Endoplasmic Reticulum Aminopeptidase 2¹ ²		EC 3.4.11.-³
LRAP¹ ² ³ ⁵		EC 3.4.11⁸
L-RAP¹ ² ³		EC 3.4.11.3⁸
Leukocyte-Derived Arginine Aminopeptidase² ³

External Ids:	HGNC: 29499¹	Entrez Gene: 64167²	Ensembl: ENSG00000164308⁷	OMIM: 609497⁵	UniProtKB: Q6P179³

Export aliases for ERAP2 gene to outside databases

Previous GC identifer: GC05P091401

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ERAP2:

Aminopeptidases hydrolyze N-terminal amino acids of proteins or peptide substrates. Major histocompatibility complex

(MHC) class I molecules rely on aminopeptidases such as ERAP1 (MIM 606832) and LRAP to trim precursors to antigenic

peptides in the endoplasmic reticulum (ER) following cleavage in the cytoplasm by tripeptidyl peptidase II (TPP2; MIM

190470) (Tanioka et al., 2003 (PubMed 12799365)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: ERAP2_HUMAN, Q6P179

Function: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA

class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the

correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg

and Lys

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_034772.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ERAP2 gene promoter:
Pbx1a Pax-2b FOXD3 Pax-2 Pax-2a POU6F1 (c2) Nkx5-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ERAP2 promoter sequence

Search SABiosciences Chromatin IP Primers for ERAP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ERAP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q15 Ensembl cytogenetic band: 5q15 HGNC cytogenetic band: 5q15

ERAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ERAP2 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P096238: view genomic region (about GC identifiers)

Start:	96,211,643 bp from pter	End:	96,255,420 bp from pter
Size:	43,778 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ERAP2_HUMAN, Q6P179 (See protein sequence)

Recommended Name: Endoplasmic reticulum aminopeptidase 2

Size: 960 amino acids; 110462 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Subunit: Heterodimer with ERAP1

Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein

Miscellaneous: Defects in the expression of this gene may cause improper antigen processing, possibly leading to favor

tumor escape from the immune surveillance

2 PDB 3D structures from and Proteopedia for ERAP2:

3SE6 (3D)

4E36 (3D)

Secondary accessions: Q7Z5K1 Q8TD32 Q8WVJ4 Q9HBX2

Alternative splicing: 4 isoforms: Q6P179-1 Q6P179-2 Q6P179-3 Q6P179-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ERAP2: NX_Q6P179

Post-translational modifications:

N-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6P179

4/6 DME Specific Peptides for ERAP2 (Q6P179) (see all 6)

TWTLQKG

GYYIVHY

WFGNLVT

GAMENWG

ERAP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001123612.1 NP_071745.1

ENSEMBL proteins:

ENSP00000400376 ENSP00000421175 ENSP00000421849 ENSP00000369235 ENSP00000425758

ENSP00000426655 ENSP00000427573 ENSP00000425415

Reactome Protein details: Q6P179
Human Recombinant Protein Products for ERAP2:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for ERAP2 (Aminopeptidase LRAP/ERAP2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for ERAP2
	GenScript Custom Purified and Recombinant Proteins Services for ERAP2
	Novus Biologicals ERAP2 Protein Novus Biologicals ERAP2 Lysates
	Sino Biological Recombinant Protein for ERAP2
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ERAP2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005788	endoplasmic reticulum lumen	TAS	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

ERAP2 for ontologies About GeneDecksing

ERAP2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	GenScript Custom Superior Antibodies Services for ERAP2
	Novus Biologicals ERAP2 Antibodies
	Abcam antibodies for ERAP2
	Uscn Antibodies for ERAP2
	ThermoFisher Antibodies for ERAP2

Assay Products for ERAP2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ERAP2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ERAP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ERAP2 for domains About GeneDecksing

3 InterPro domains/families:

IPR014782 Peptidase_M1_N

IPR024571 DUF3358

IPR001930 Peptidase_M1

Graphical View of Domain Structure for InterPro Entry Q6P179

ProtoNet protein and cluster: Q6P179

UniProtKB/Swiss-Prot: ERAP2_HUMAN, Q6P179

Similarity: Belongs to the peptidase M1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ERAP2_HUMAN, Q6P179

Function: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA

class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the

correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg

and Lys

Induction: By IFNG/IFN-gamma

Enzyme Numbers (IUBMB): EC 3.4.11.-¹ EC 3.4.11.3² EC 3.4.11²

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004177	aminopeptidase activity	IDA	12799365
GO:0004222	metalloendopeptidase activity	IEA	--
GO:0008237	metallopeptidase activity	IDA	12799365
GO:0008270	zinc ion binding	TAS	12799365

ERAP2 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for ERAP2:

Decreased BPV1 E2 protein expr

Increased HPV18 LCR reporter a

Increased Salmonella enterica

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ERAP2

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ERAP2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ERAP2
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate ERAP2:
		hsa-miR-548a-3p hsa-miR-92a-1* hsa-miR-526b hsa-miR-548e
		SwitchGear 3'UTR luciferase reporter plasmid: ERAP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ERAP2 OriGene shRNA RFP: ERAP2 OriGene siRNA: ERAP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ERAP2
		Sirion Biotech Custom design and validation of potent shRNA sequences against ERAP2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ERAP2
			Sirion Biotech Customized adenovirus for overexpression of ERAP2 Sirion Biotech Customized adenovirus for potent knockdown of ERAP2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ERAP2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ERAP2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ERAP2 (NM_022350)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERAP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERAP2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ERAP2
		Search LifeMap BioReagents cell lines for ERAP2
		Sirion Biotech Customized stable knockdown cell line services for ERAP2 Sirion Biotech Customized inducible knockdown cell line services for ERAP2 Sirion Biotech Customized stable overexpressing cell line services for ERAP2 Sirion Biotech Customized inducible overexpressing cell line services for ERAP2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERAP2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Trimming of peptides in ER

Trimming of peptides in ER

1.00

Antigen processing: Ubiquitination & Proteasome degradation

Class I MHC mediated antigen processing & presentation

0.83

Translocation of peptide bound MHC class I complex to cell surface

Antigen Presentation: Folding, assembly and peptide loading of class I MHC

0.28

Pathway sources
See GeneCards unified pathways
Show all pathways

5 Reactome Pathways for ERAP2

	Antigen Presentation: Folding, assembly and peptide loading of class I MHC
	Adaptive Immune System
	Class I MHC mediated antigen processing & presentation
	Immune System
	Trimming of peptides in ER

ERAP2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ERAP2

1 Interacting protein for ERAP2 (Q6P179³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ERAP1	Q9NZ08³	I2D: score=1

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	TAS	--
GO:0006508	proteolysis	IEA	--
GO:0008217	regulation of blood pressure	TAS	12799365
GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I	TAS	15691326

ERAP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ERAP2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ERAP2
4 Novoseek chemical compound relationships for ERAP2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hydroxyapatite	56.2	5	15299015 (2), 16674706 (1), 16674705 (1)
leucine	41.1	7	19850130 (1), 15691326 (1), 12799365 (1), 16054015 (1)
arginine	36.9	12	12799365 (3), 15691326 (2), 18466591 (1), 17129607 (1) (see all 5)
proline	25.2	1	9715666 (1)

Search CenterWatch for drugs/clinical trials and news about ERAP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ERAP2 gene (2 alternative transcripts):

NM_001130140.1 NM_022350.3

Unigene Cluster for ERAP2:

Endoplasmic reticulum aminopeptidase 2

Hs.482910 [show with all ESTs]

Unigene Representative Sequence: NM_022350

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000437043(uc003kmq.3 uc003kmt.3 uc003kmr.3 uc003kms.3 uc003kmu.3)

ENST00000510373 ENST00000513084 ENST00000379904 ENST00000510309 ENST00000507346

ENST00000508077 ENST00000515095 ENST00000515387 ENST00000513368 ENST00000512869

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ERAP2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ERAP2
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate ERAP2:
		hsa-miR-548a-3p hsa-miR-92a-1* hsa-miR-526b hsa-miR-548e
		SwitchGear 3'UTR luciferase reporter plasmid: ERAP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ERAP2 OriGene shRNA RFP: ERAP2 OriGene siRNA: ERAP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ERAP2
		Sirion Biotech Custom design and validation of potent shRNA sequences against ERAP2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ERAP2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ERAP2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ERAP2 (NM_022350)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERAP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERAP2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ERAP2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat ERAP2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ERAP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ERAP2

Additional cDNA sequence:

AB109031.1 AF191545.1 AK074213.1 AK074281.1 AK074387.1 AK312864.1 BC017927.2 BC065240.1

11 DOTS entries:

DT.95150093 DT.410977 DT.70105296 DT.97762073 DT.100779286 DT.101964618 DT.100779288 DT.99929679

DT.95132452 DT.100773436 DT.75137702

24/142 AceView cDNA sequences (see all 142):

AI367512 AI147163 CB112167 BU155655 AA744752 BQ053677 AI276287 NM_022350

AI335035 BC065240 CB124945 BQ943632 BE467049 BQ690102 BC017927 AA565542

BE646306 BU620539 AI539156 AF191545 CR610687 AW471324 BM916969 BG030257

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for ERAP2 (see all 13) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	^	10a	·	10b	^	11a	·	11b	^	12	^	13a	·	13b	^	14	^	15a	·	15b	^
SP1:			-																-																				-								-
SP2:																																							-
SP3:																																							-								-
SP4:													-						-
SP5:																																															-

ExUns:	16	^	17	^	18a	·	18b	·	18c	^	19	^	20a	·	20b	·	20c	^	21a	·	21b	^	22
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ERAP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ERAP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ERAP2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ERAP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ERAP2

SOURCE GeneReport for Unigene cluster: Hs.482910

UniProtKB/Swiss-Prot: ERAP2_HUMAN, Q6P179

Tissue specificity: Ubiquitously expressed. Highly expressed in spleen and leukocytes

SABiosciences Custom PCR Arrays for ERAP2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ERAP2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat ERAP2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ERAP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ERAP2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERAP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ERAP2 gene from 3/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	erap2¹	endoplasmic reticulum aminopeptidase 2	60.24(n) 58.81(a)		100144556 NM_001123052.1 NP_001116524.1
honey bee (Apis mellifera)	Insecta	-- --	--	33(a) 28(a)	possible ortholog possible ortholog	GroupUn.6298(9080-17993) Group4.16(111874-116967)
worm (Caenorhabditis elegans)	Secernentea	CELE_F49B2.6¹	Protein F49B2.6	45.07(n) 32.27(a)		173297 NM_061102.2 NP_493503.2

ENSEMBL Gene Tree for ERAP2 (if available)
TreeFam Gene Tree for ERAP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ERAP2 gene

ENPEP² TRHDE² AQPEP² NPEPPS² ENSG00000174093² LNPEP² ANPEP² ERAP1²

11 SIMAP similar genes for ERAP2 using alignment to 5 protein entries: ERAP2_HUMAN (see all proteins):

CD13 ERAP1 LNPEP ANPEP NPEPPSL1 TRHDE

TBC1D3 ENPEP NPEPPS AQPEP FLJ90650

ERAP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192023619^1,2		--	96209682(+)	`CCAACA/GAGGAG`	2	--	us2k¹		0	--	--	--	--
rs74511542^1,2	F	--	96209774(+)	`CAAAGC/TTTATC`	2	--	us2k¹		1		NA	120
rs142509426^1,2	C	--	96209821(+)	`GGAAG-/GAAA GAAAG`	2	--	us2k¹		0	--	--	--	--
rs13169652^1,2	C	--	96209831(+)	`aaagaG/Aagaga`	2	--	us2k¹ trp³		1		NA	2
rs13186840^1,2	C	--	96209839(+)	`agagaA/Gagaaa`	2	--	us2k¹ trp³		1		NA	2
rs184626457^1,2		--	96209862(+)	`GAAAGA/GAAGAA`	2	--	us2k¹		0	--	--	--	--
rs138542039^1,2		--	96209874(+)	`GAAAG-/AAAG AAAGAAAGAGA`	2	--	us2k¹		0	--	--	--	--
rs150352848^1,2	C	--	96209882(+)	`GAAAG-/AAAGAGA`	2	--	us2k¹		0	--	--	--	--
rs13186863^1,2		--	96209887(+)	`AAAGAA/GAGAGA`	2	--	us2k¹ trp³		0	--	--	--	--
rs114228336^1,2	F	--	96209904(+)	`AGAAAG/TAAAAG`	2	--	us2k¹		1		NA	120

HapMap Linkage Disequilibrium report for ERAP2 (96211643 - 96255420 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ERAP2: --
Human Gene Mutation Database (HGMD): ERAP2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ERAP2 for disorders           About GeneDecksing

OMIM gene information: 609497    OMIM disorders: --

10 diseases for ERAP2:    About MalaCards

ankylosing spondylitis mantle cell lymphoma leukemia/lymphoma spondylitis

crohn's disease hepatocellular carcinoma leukemia neuroblastoma

melanoma carcinoma

1 Novoseek disease relationship for ERAP2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	4	16585582 (3)

Human Genome Epidemiology (HuGE) Navigator: ERAP2 (7 documents)

Export disorders for ERAP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ERAP2 gene, integrated from 9 sources (see all 48):
(articles sorted by number of sources associating them with ERAP2)

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Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases. (PubMed id 12799365)^{1, 2, 3, 9} Tanioka T.... Tsujimoto M. (2003)
Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum. (PubMed id 15908954)^{1, 2, 3} Saveanu L....van Endert P.M. (2005)
Regulation of the human leukocyte-derived arginine aminopeptidase/endoplasmic reticulum-aminopeptidase 2 gene by interferon-gamma. (PubMed id 15691326)^{1, 2, 9} Tanioka T.... Tsujimoto M. (2005)
Expression of endoplasmic reticulum aminopeptidases in EBV-B cell lines from healthy donors and in leukemia/lymphoma, carcinoma, and melanoma cell lines. (PubMed id 16585582)^{1, 2, 9} Fruci D....Giacomini P. (2006)
The crystal structure of human endoplasmic reticulum a minopeptidase 2 reveals the atomic basis for distinct roles in antigen processin g. (PubMed id 22106953)^{1, 2} Birtley J.R....Mavridis I.M. (2012)
The ERAP2 gene is associated with preeclampsia in Aus tralian and Norwegian populations. (PubMed id 19578876)^{1, 9} Johnson M.P....Moses E.K. (2009)
Altered expression of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in transformed non-lymphoid human tissues. (PubMed id 18393273)^{1, 9} Fruci D....Natali P.G. (2008)
No association of type 1 diabetes with a functional polymorphism of the LRAP gene. (PubMed id 17129607)^{1, 9} Qu H.Q....Polychronakos C. (2007)
Distinct molecular mechanisms leading to deficient ex pression of ER-resident aminopeptidases in melanoma. (PubMed id 20419298)^{1, 9} Kamphausen E....Seliger B. (2010)
Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis. (PubMed id 19433412)^{1, 9} Tsui F.W....Inman R.D. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 64167	HGNC: 29499	AceView: LRAP	Ensembl:ENSG00000164308	euGenes: HUgn64167
ECgene: ERAP2	H-InvDB: ERAP2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ERAP2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ERAP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ERAP2 gene:
Search GeneIP for patents involving ERAP2

GeneCards and IP:
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endoplasmic reticulum aminopeptidase 2

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endoplasmic reticulum aminopeptidase 2

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