Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ERAP1 Gene

protein-coding   GIFtS: 65
GCID: GC05M096124

Endoplasmic Reticulum Aminopeptidase 1

  See ERAP1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Endoplasmic Reticulum Aminopeptidase 11 2     PILS-AP2 3
Adipocyte-Derived Leucine Aminopeptidase1 2 3     ALAP2 5
Puromycin-Insensitive Leucyl-Specific Aminopeptidase1 2 3     PILSAP2 5
ARTS12 3 5     KIAA05253 5
Aminopeptidase Regulator Of TNFR1 Shedding1 2     ERAAP2
Aminopeptidase PILS2 3     ERAAP12
Type 1 Tumor Necrosis Factor Receptor Shedding Aminopeptidase Regulator2 3     Endoplasmic Reticulum Aminopeptidase Associated With Antigen Processing2
A-LAP2 3     EC 3.4.11.-3
APPILS2 3     EC 3.4.118
ARTS-12 3     EC 3.4.11.38

External Ids:    HGNC: 181731   Entrez Gene: 517522   Ensembl: ENSG000001643077   OMIM: 6068325   UniProtKB: Q9NZ083   

Export aliases for ERAP1 gene to outside databases

Previous GC identifer: GC05M091286


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ERAP1 Gene:
The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that
they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with
ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three
transcript variants encoding two different isoforms have been found for this gene.(provided by RefSeq, Oct 2010)

GeneCards Summary for ERAP1 Gene:
ERAP1 (endoplasmic reticulum aminopeptidase 1) is a protein-coding gene. Diseases associated with ERAP1 include juvenile psoriatic arthritis, and ankylosing spondylitis. GO annotations related to this gene include interleukin-6 receptor binding and aminopeptidase activity. An important paralog of this gene is LNPEP.

UniProtKB/Swiss-Prot: ERAP1_HUMAN, Q9NZ08
Function: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most
HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to
the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues
long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides
with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a
role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the
inactivation of angiotensin II and/or the generation of bradykinin in the kidney

Gene Wiki entry for ERAP1 (ARTS-1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the ERAP1 gene promoter:
         Nkx2-5   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   HNF-1A   E47   HOXA5   HNF-1   POU2F1c   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ERAP1 promoter sequence
   Search Chromatin IP Primers for ERAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ERAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q15   Ensembl cytogenetic band:  5q15   HGNC cytogenetic band: 5q15

ERAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ERAP1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M096124:  view genomic region     (about GC identifiers)

Start:
96,096,514 bp from pter      End:
96,149,848 bp from pter
Size:
53,335 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ERAP1_HUMAN, Q9NZ08 (See protein sequence)
Recommended Name: Endoplasmic reticulum aminopeptidase 1  
Size: 941 amino acids; 107235 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Monomer. May also exist as a heterodimer; with ERAP2. Interacts with RBMX
Caution: It is uncertain whether Met-1 or Met-13 is the initiator
Sequence caution: Sequence=BAA25451.2; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for ERAP1:
2YD0 (3D)        3MDJ (3D)        3QNF (3D)        3RJO (3D)    
Secondary accessions: O60278 Q6UWY6 Q8NEL4 Q8TAD0 Q9UHF8 Q9UKY2
Alternative splicing: 2 isoforms:  Q9NZ08-1   Q9NZ08-2   

Explore the universe of human proteins at neXtProt for ERAP1: NX_Q9NZ08

Explore proteomics data for ERAP1 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn70, Asn154, Asn414, Asn760, Asn901
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ERAP1 (Q9NZ08) (see all 9)
     GYYIVHY  STYLVAF  WFGNLVT  WLNEGFA 


    See ERAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001035548.1  NP_001185470.1  NP_057526.3  

    ENSEMBL proteins: 
     ENSP00000296754   ENSP00000406304   ENSP00000425381   ENSP00000427025   ENSP00000422631  
     ENSP00000421697  
    Reactome Protein details: Q9NZ08

    ERAP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ERAP1 (Aminopeptidase PILS/ARTS1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for ERAP1
    OriGene Protein Over-expression Lysate for ERAP1
    OriGene MassSpec for ERAP1
    OriGene Custom Protein Services for ERAP1
    GenScript Custom Purified and Recombinant Proteins Services for ERAP1
    Novus Biologicals ERAP1 Protein
    Novus Biologicals ERAP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ERAP1

     
    Search eBioscience for Proteins for ERAP1 

    ERAP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for ERAP1 (Aminopeptidase PILS/ARTS1)
    OriGene Antibodies for ERAP1
    OriGene Custom Antibody Services for ERAP1
    Novus Biologicals ERAP1 Antibodies
    Abcam antibodies for ERAP1
    Cloud-Clone Corp. Antibodies for ERAP1
    ThermoFisher Antibodies for ERAP1
    LSBio Antibodies in human, mouse, rat for ERAP1

    ERAP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ERAP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ERAP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ERAP1
    Cloud-Clone Corp. CLIAs for ERAP1
    Search eBioscience for ELISAs for ERAP1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: Endoplasmic reticulum aminopeptidase 1
    Aminopeptidases

    3 InterPro protein domains:
     IPR014782 Peptidase_M1_N
     IPR024571 ERAP1-like_C_dom
     IPR001930 Peptidase_M1

    Graphical View of Domain Structure for InterPro Entry Q9NZ08

    ProtoNet protein and cluster: Q9NZ08

    1 Blocks protein domain: IPB001930 Membrane alanyl dipeptidase (M1) family signature

    UniProtKB/Swiss-Prot: ERAP1_HUMAN, Q9NZ08
    Similarity: Belongs to the peptidase M1 family


    Find genes that share domains with ERAP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ERAP1_HUMAN, Q9NZ08
    Function: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most
    HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to
    the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues
    long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides
    with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a
    role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the
    inactivation of angiotensin II and/or the generation of bradykinin in the kidney
    Catalytic activity: Release of an N-terminal amino acid, Xaa- -Xbb-, in which Xaa is preferably Leu, but may be
    other amino acids including Met, Cys and Phe
    Induction: By IFNG/IFN-gamma

         Enzyme Numbers (IUBMB): EC 3.4.11.-1 EC 3.4.11.32 EC 3.4.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity IDA10220586
    GO:0005138interleukin-6 receptor binding IPI12748171
    GO:0005151interleukin-1, Type II receptor binding TAS15691326
    GO:0005515protein binding IPI18445477
    GO:0008235metalloexopeptidase activity IDA10220586
         
    Find genes that share ontologies with ERAP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ERAP1:
     Decreased melanin production 

         4 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Erap1):
     hematopoietic system  immune system  no phenotypic analysis  renal/urinary system 

    Find genes that share phenotypes with ERAP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ERAP1: Erap1tm1Luc Erap1tm1.1Gnie Erap1tm1Iay Erap1tm1Nsha Erap1tm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ERAP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ERAP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ERAP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ERAP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ERAP1:
    hsa-mir-92a-3p (MIRT049298), hsa-mir-26b-5p (MIRT030332), hsa-mir-335-5p (MIRT019189)

    Block miRNA regulation of human, mouse, rat ERAP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ERAP1 (see all 30):
    hsa-miR-323-3p hsa-miR-30c hsa-miR-502-5p hsa-miR-16-2* hsa-miR-125a-3p hsa-miR-30d hsa-miR-944 hsa-miR-3171
    SwitchGear 3'UTR luciferase reporter plasmidERAP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ERAP1
    Predesigned siRNA for gene silencing in human, mouse, rat ERAP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ERAP1

    Clone
    Products:
         
    OriGene clones in human, mouse for ERAP1 (see all 15)
    OriGene ORF clones in mouse, rat for ERAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ERAP1 (NM_001198541)
    Sino Biological Human cDNA Clone for ERAP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERAP1
    Addgene plasmids for ERAP1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ERAP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ERAP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERAP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ERAP1_HUMAN, Q9NZ08: Endoplasmic reticulum membrane; Single-pass type II membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endoplasmic reticulum5
    extracellular5
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA11056387
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum NAS12748171
    GO:0005788endoplasmic reticulum lumen TAS15691326
    GO:0005789endoplasmic reticulum membrane IEA--

    Find genes that share ontologies with ERAP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ERAP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    2TWEAK Pathway
    Apoptosis and survival TNFR1 signaling pathway0.52
    3ER to Golgi Transport
    Antigen Presentation- Folding, assembly and peptide loading of class I MHC0.32


    Find genes that share SuperPaths with ERAP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ERAP1
        Apoptosis and survival TNFR1 signaling pathway


    1 Reactome Pathway for ERAP1
        Antigen Presentation: Folding, assembly and peptide loading of class I MHC


        Pathway & Disease-focused RT2 Profiler PCR Arrays including ERAP1: 
              Growth Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ERAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for ERAP1 (Q9NZ081, 3 ENSP000002967544) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL6RP088871, 3, ENSP000003574704EBI-299412,EBI-299383 I2D: score=2 STRING: ENSP00000357470
    TNFRSF1AP194383, ENSP000001627494I2D: score=4 STRING: ENSP00000162749
    ARFGEF2Q9Y6D53I2D: score=1 
    ERAP2Q6P1793I2D: score=1 
    NUCB2P803033I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis TAS15691326
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0006508proteolysis ----
    GO:0006509membrane protein ectodomain proteolysis IDA12748171
    GO:0008217regulation of blood pressure TAS15691326

    Find genes that share ontologies with ERAP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ERAP1

    1 HMDB Compound for ERAP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    BradykininCallidin I (see all 5)58-82-2--

    4 Novoseek inferred chemical compound relationships for ERAP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kallidin 73.1 1 14691298 (1)
    leucine 70.5 34 11481040 (3), 15314084 (2), 10220586 (2), 11857741 (2) (see all 15)
    ang ii 52.4 4 14654715 (2), 15741767 (1)
    vegf 20.7 5 14695154 (2), 15741767 (2), 16769060 (1)



    Find genes that share compounds with ERAP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ERAP1 gene (3 alternative transcripts): 
    NM_001040458.1  NM_001198541.1  NM_016442.3  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296754(uc003kml.3) ENST00000443439(uc003kmm.3 uc003kmn.3)
    ENST00000512852 ENST00000514604 ENST00000507859 ENST00000503311 ENST00000503921
    ENST00000508227 ENST00000507154
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ERAP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ERAP1 (see all 30):
    hsa-miR-323-3p hsa-miR-30c hsa-miR-502-5p hsa-miR-16-2* hsa-miR-125a-3p hsa-miR-30d hsa-miR-944 hsa-miR-3171
    SwitchGear 3'UTR luciferase reporter plasmidERAP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ERAP1
    Predesigned siRNA for gene silencing in human, mouse, rat ERAP1
    Clone
    Products:
         
    OriGene clones in human, mouse for ERAP1 (see all 15)
    OriGene ORF clones in mouse, rat for ERAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ERAP1 (NM_001198541)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ERAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERAP1
    Addgene plasmids for ERAP1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ERAP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ERAP1
      QuantiTect SYBR Green Assays in human, mouse, rat ERAP1
      QuantiFast Probe-based Assays in human, mouse, rat ERAP1

    Selected AceView cDNA sequences (see all 198):

    BU624113 AA579916 CD515426 AA491080 AL702989 AK094985 CF138097 BX395862 
    AA251904 BC019347 CB108940 Z98524 CA395050 AA765630 AA490894 CA313060 
    BQ016692 AI632045 R50175 AL553834 BG057181 AL601936 AW274499 AI634860 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ERAP1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^
    SP1:                    -                                                                                   -                                                   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                    -                       -     -     -     -     -     -     -                                                                           
    SP5:                                                                                                                                                            

    ExUns: 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21
    SP1:        -                                                         
    SP2:                                                                  
    SP3:                                                        -         
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for ERAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ERAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATATTGA
    ERAP1 Expression
    About this image


    ERAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ERAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ERAP1 Protein Expression

    UniProtKB/Swiss-Prot: ERAP1_HUMAN, Q9NZ08
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ERAP1: 
              Growth Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ERAP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ERAP1
    QuantiTect SYBR Green Assays in human, mouse, rat ERAP1
    QuantiFast Probe-based Assays in human, mouse, rat ERAP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ERAP1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Erap11 , 5 endoplasmic reticulum aminopeptidase 11, 5 86.3(n)1
    86.23(a)1
      13 (40.48 cM)5
    808981  NM_030711.41  NP_109636.11 
     746398725 
    chicken
    (Gallus gallus)
    Aves ERAP11 endoplasmic reticulum aminopeptidase 1 70.82(n)
    69.24(a)
      427122  XM_001232417.3  XP_001232418.2 
    lizard
    (Anolis carolinensis)
    Reptilia ERAP16
    endoplasmic reticulum aminopeptidase 1
    66(a)
    1 ↔ 1
    2(26484998-26512846)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia erap11 endoplasmic reticulum aminopeptidase 1 67.64(n)
    66.93(a)
      100496768  XM_002933429.2  XP_002933475.2 
    zebrafish
    (Danio rerio)
    Actinopterygii BC045983.12   -- 77.2(n)   393175  BC045983.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG44676
    --
    21(a)
    1 → many
    3R(19053439-19074623)
    worm
    (Caenorhabditis elegans)
    Secernentea F49B2.66
    Protein F49B2.6 (F49B2.6) mRNA, complete cds
    24(a)
    1 → many
    I(14331085-14339839) WBGene00009865


    ENSEMBL Gene Tree for ERAP1 (if available)
    TreeFam Gene Tree for ERAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ERAP1 gene
    LNPEP2  ENPEP2  TRHDE2  ANPEP2  LOC1010602122  NPEPPS2  AQPEP2  ERAP22  
    8 SIMAP similar genes for ERAP1 using alignment to 3 protein entries:     ERAP1_HUMAN (see all proteins):
    ERAP2    LNPEP    ENPEP    ANPEP    AQPEP    FLJ90650
    TRHDE    NPEPPS

    Find genes that share paralogs with ERAP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ERAP1 (see all 1173)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs727739241,2
    --91307966(+) TTACAA/CTTTTT 3 -- int10--------
    rs2008636861,2
    C--91309785(+) CACAC-/ACACACA
    CACACACAT
    ACACA
    3 -- int10--------
    rs1134457761,2
    C,F--91341548(+) GGGGTC/TTCTTC 1 -- us2k11Minor allele frequency- T:0.00CSA 1
    rs38393001,2
    C--96110969(-) TCTTTCTTT/-  
            
    TGTGA
    5 -- ut31 cds1 int1 trp31Minor allele frequency- -:0.50CSA 2
    rs1469250651,2
    C--96110969(+) TCACA-/AAAG  
            
    AAAGA
    3 -- ut31 int10--------
    rs615012161,2
    C--96110970(+) AAAGA-/AAGA  
            
    CTTCA
    3 -- ut31 int11Minor allele frequency- AAGA:0.00NA 2
    rs2017726241,2
    C--96110972(+) CAAAAA/GAAAGA 3 -- ut31 int10--------
    rs1929485171,2
    --96111004(+) GTCCTA/GTTTGC 3 -- ut31 int10--------
    rs340233491,2
    C--96111043(+) GTACT-/ATCA  
            
    ATCAT
    3 -- ut31 int10--------
    rs719028341,2
    C--96111044(+) TACTA-/ATCA  
            
    TCATT
    3 -- ut31 int10--------

    HapMap Linkage Disequilibrium report for ERAP1 (96096514 - 96149848 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ERAP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830411CNV Loss17160897
    nsv436983CNV Loss16327808
    nsv516293CNV Gain+Loss19592680

    Human Gene Mutation Database (HGMD): ERAP1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ERAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for ERAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606832    OMIM disorders: --

    4 diseases for ERAP1:    
    About MalaCards
    juvenile psoriatic arthritis    ankylosing spondylitis    psoriatic arthritis    endometrial carcinoma

    2 diseases from the University of Copenhagen DISEASES database for ERAP1:
    Ankylosing spondylitis     Psoriasis

    Find genes that share disorders with ERAP1           About GenesLikeMe

    4 Novoseek inferred disease relationships for ERAP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    essential hypertension 40.9 3 13678427 (2), 19578876 (1)
    endometrial carcinoma 31.5 7 14695154 (3), 15741767 (2)
    tumors 3.79 8 16585582 (3), 14654715 (1), 20367925 (1), 14695154 (1) (see all 5)
    adenocarcinoma 0 4 15741767 (3), 14654715 (1)

    Genetic Association Database (GAD): ERAP1
    Human Genome Epidemiology (HuGE) Navigator: ERAP1 (30 documents)

    Export disorders for ERAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ERAP1 gene, integrated from 10 sources (see all 112):
    (articles sorted by number of sources associating them with ERAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a 'molecular ruler' mechanism. (PubMed id 16286653)1, 2, 3, 9 Chang S.-C.... Goldberg A.L. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    2. Molecular cloning of adipocyte-derived leucine aminopeptidase highly related to placental leucine aminopeptidase/oxytocinase. (PubMed id 10220586)1, 2, 3, 9 Hattori A.... Tsujimoto M. (J. Biochem. 1999)
    3. Identification of ARTS-1 as a novel TNFR1-binding protein that promotes TNFR1 ectodomain shedding. (PubMed id 12189246)1, 3, 9 Cui X....Levine S.J. (J. Clin. Invest. 2002)
    4. Association of ARTS1 gene polymorphisms with ankylosing spondylitis in the Hungarian population: the rs27044 variant is associated with HLA-B*2705 subtype in Hungarian patients with ankylosing spondylitis. (PubMed id 20032103)1, 4, 9 PazA!r B....PoA^r G. (J. Rheumatol. 2010)
    5. Association of a specific ERAP1/ARTS1 haplotype with disease susceptibility in ankylosing spondylitis. (PubMed id 19404951)1, 4, 9 Maksymowych W.P....Rahman P. (Arthritis Rheum. 2009)
    6. Genomic organization of the human adipocyte-derived leucine aminopeptidase gene and its relationship to the placental leucine aminopeptidase/oxytocinase gene. (PubMed id 11481040)1, 2, 9 Hattori A.... Tsujimoto M. (J. Biochem. 2001)
    7. Characterization of recombinant human adipocyte-derived leucine aminopeptidase expressed in Chinese hamster ovary cells. (PubMed id 11056387)1, 2, 9 Hattori A.... Tsujimoto M. (J. Biochem. 2000)
    8. An association between RBMX, a heterogeneous nuclear ribonucleoprotein, and ARTS-1 regulates extracellular TNFR1 release. (PubMed id 18445477)1, 2, 9 Adamik B.... Levine S.J. (Biochem. Biophys. Res. Commun. 2008)
    9. Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis. (PubMed id 19433412)1, 4, 9 Tsui F.W....Inman R.D. (Ann. Rheum. Dis. 2010)
    10. The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations. (PubMed id 19578876)1, 4, 9 Johnson M.P....Moses E.K. (Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 51752 HGNC: 18173 AceView: ARTS-1 Ensembl:ENSG00000164307 euGenes: HUgn51752
    ECgene: ERAP1 H-InvDB: ERAP1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0525

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ERAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ERAP1 gene:
    Search GeneIP for patents involving ERAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for ERAP1 (Aminopeptidase PILS/ARTS1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for ERAP1 (Aminopeptidase PILS/ARTS1)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ERAP1   OriGene RNAi products in human, mouse, rat for ERAP1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ERAP1  
     OriGene MassSpec something-or-other for ERAP1   OriGene clones in human, mouse for ERAP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ERAP1   OriGene Purified Protein for ERAP1  
     OriGene ORF clones in mouse, rat for ERAP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ERAP1   OriGene Custom Protein Services for ERAP1  

     
     
     Block miRNA regulation of human, mouse, rat ERAP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ERAP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ERAP1 Predesigned siRNA for gene silencing in human, mouse, rat ERAP1
     QuantiFast Probe-based Assays in human, mouse, rat ERAP1 QuantiTect SYBR Green Assays in human, mouse, rat ERAP1
     PCR Arrays including human, mouse, rat ERAP1 Search Chromatin IP Primers for ERAP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ERAP1  GeneGlobe Interaction Network for ERAP1
     Regulatory tfbs in ERAP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ERAP1 GenScript cDNA clones with any tag delivered in your preferred vector for ERAP1
     GenScript Custom Assay Services for ERAP1 GenScript Custom overexpressing Cell Line Services for ERAP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ERAP1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ERAP1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ERAP1 antibodies
     ERAP1 proteins
     ERAP1 lysates
     Antibodies for ERAP1
     See all of Abcam's Antibodies, Kits and Proteins for ERAP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ERAP1
     Antibodies for ERAP1
     ELISAs for ERAP1
     CLIAs for ERAP1



     Browse ESI BIO Cell Lines and PureStem Progenitors for ERAP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERAP1
     SwitchGear 3'UTR luciferase reporter plasmids for ERAP1
     SwitchGear Promoter luciferase reporter plasmids for ERAP1
     ThermoFisher Antibodies for ERAP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERAP1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ERAP1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ERAP1
     LSBio Antibodies in human, mouse, rat for ERAP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for ERAP1
      Search eBioscience for proteins for ERAP1
      Search eBioscience for elisas for ERAP1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ERAP1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4