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Aliases for ERAL1 Gene

Aliases for ERAL1 Gene

  • Era Like 12S Mitochondrial RRNA Chaperone 1 2 3
  • Era-Like 12S Mitochondrial RRNA Chaperone 1 2 3 5
  • Era (E. Coli G-Protein Homolog)-Like 1 2 3
  • Conserved ERA-Like GTPase 3 4
  • ERA-Like Protein 1 3 4
  • ERA-W 3 4
  • H-ERA 3 4
  • CEGA 3 4
  • GTPase, Human Homolog Of E. Coli Essential Cell Cycle Protein Era 3
  • GTP-Binding Protein Era Homolog 3
  • Era G-Protein-Like 1 (E. Coli) 2
  • Era G-Protein-Like 1 3
  • ERAL1A 3
  • HERA-A 3
  • HERA-B 3
  • HERA 4
  • ERA 3

External Ids for ERAL1 Gene

Previous GeneCards Identifiers for ERAL1 Gene

  • GC17P027027
  • GC17P029081
  • GC17P027327
  • GC17P024206
  • GC17P027182
  • GC17P023390

Summaries for ERAL1 Gene

Entrez Gene Summary for ERAL1 Gene

  • The protein encoded by this gene is a GTPase that localizes to the mitochondrion. The encoded protein binds to the 3' terminal stem loop of 12S mitochondrial rRNA and is required for proper assembly of the 28S small mitochondrial ribosomal subunit. Deletion of this gene has been shown to cause mitochondrial dysfunction, growth retardation, and apoptosis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for ERAL1 Gene

ERAL1 (Era Like 12S Mitochondrial RRNA Chaperone 1) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway. GO annotations related to this gene include poly(A) RNA binding and GTP binding.

UniProtKB/Swiss-Prot for ERAL1 Gene

  • Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3 terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERAL1 Gene

Genomics for ERAL1 Gene

Regulatory Elements for ERAL1 Gene

Promoters for ERAL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ERAL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ERAL1 Gene

Chromosome:
17
Start:
28,854,938 bp from pter
End:
28,861,067 bp from pter
Size:
6,130 bases
Orientation:
Plus strand

Genomic View for ERAL1 Gene

Genes around ERAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERAL1 Gene

Proteins for ERAL1 Gene

  • Protein details for ERAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75616-ERAL1_HUMAN
    Recommended name:
    GTPase Era, mitochondrial
    Protein Accession:
    O75616
    Secondary Accessions:
    • B3KN21
    • C9JEC6
    • O75617
    • Q8WUY4
    • Q96LE2
    • Q96TC0

    Protein attributes for ERAL1 Gene

    Size:
    437 amino acids
    Molecular mass:
    48350 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG12978.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ERAL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERAL1 Gene

Proteomics data for ERAL1 Gene at MOPED

Post-translational modifications for ERAL1 Gene

  • Ubiquitination at Lys 393 and Lys 398
  • Modification sites at PhosphoSitePlus

Other Protein References for ERAL1 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ERAL1

No data available for DME Specific Peptides for ERAL1 Gene

Domains & Families for ERAL1 Gene

Suggested Antigen Peptide Sequences for ERAL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75616

UniProtKB/Swiss-Prot:

ERAL1_HUMAN :
  • Contains 1 Era-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
Domain:
  • Contains 1 Era-type G (guanine nucleotide-binding) domain.
  • Contains 1 KH type-2 domain.
Family:
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
genes like me logo Genes that share domains with ERAL1: view

No data available for Gene Families for ERAL1 Gene

Function for ERAL1 Gene

Molecular function for ERAL1 Gene

UniProtKB/Swiss-Prot Function:
Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3 terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.

Gene Ontology (GO) - Molecular Function for ERAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ERAL1: view
genes like me logo Genes that share phenotypes with ERAL1: view

Animal Model Products

miRNA for ERAL1 Gene

miRTarBase miRNAs that target ERAL1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ERAL1 Gene

Localization for ERAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERAL1 Gene

Mitochondrion matrix. Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes on the matrix side on the mitochondrial inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ERAL1 Gene COMPARTMENTS Subcellular localization image for ERAL1 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
cytosol 3
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for ERAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
GO:0005759 mitochondrial matrix IDA 20604745
genes like me logo Genes that share ontologies with ERAL1: view

Pathways & Interactions for ERAL1 Gene

genes like me logo Genes that share pathways with ERAL1: view

Pathways by source for ERAL1 Gene

1 BioSystems pathway for ERAL1 Gene

Gene Ontology (GO) - Biological Process for ERAL1 Gene

None

No data available for SIGNOR curated interactions for ERAL1 Gene

Drugs & Compounds for ERAL1 Gene

(1) Drugs for ERAL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ERAL1: view

Transcripts for ERAL1 Gene

Unigene Clusters for ERAL1 Gene

Era G-protein-like 1 (E. coli):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERAL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10
SP1: - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5:
SP6:
SP7:

Relevant External Links for ERAL1 Gene

GeneLoc Exon Structure for
ERAL1
ECgene alternative splicing isoforms for
ERAL1

Expression for ERAL1 Gene

mRNA expression in normal human tissues for ERAL1 Gene

Protein differential expression in normal tissues from HIPED for ERAL1 Gene

This gene is overexpressed in Lung (30.4), Breast (25.5), and Bone (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ERAL1 Gene



SOURCE GeneReport for Unigene cluster for ERAL1 Gene Hs.3426

genes like me logo Genes that share expression patterns with ERAL1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ERAL1 Gene

Orthologs for ERAL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ERAL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ERAL1 35
  • 84.44 (n)
  • 81.24 (a)
ERAL1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ERAL1 35
  • 85.51 (n)
  • 80.55 (a)
cfa-mir-451 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eral1 35
  • 82.91 (n)
  • 78.26 (a)
Eral1 16
Eral1 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ERAL1 35
  • 99.31 (n)
  • 99.08 (a)
ERAL1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eral1 35
  • 83.06 (n)
  • 78.42 (a)
oppossum
(Monodelphis domestica)
Mammalia ERAL1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ERAL1 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves ERAL1 35
  • 61.58 (n)
  • 58.62 (a)
ERAL1 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ERAL1 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495069 35
  • 60.25 (n)
  • 60.43 (a)
Str.11903 35
zebrafish
(Danio rerio)
Actinopterygii eral1 35
  • 56.78 (n)
  • 54.18 (a)
eral1 36
  • 45 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010622 35
  • 49.22 (n)
  • 36.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7488 35
  • 45.7 (n)
  • 32.58 (a)
CG7488 36
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea E02H1.2 35
  • 41.15 (n)
  • 30 (a)
E02H1.2 36
  • 26 (a)
OneToOne
Species with no ortholog for ERAL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ERAL1 Gene

ENSEMBL:
Gene Tree for ERAL1 (if available)
TreeFam:
Gene Tree for ERAL1 (if available)

Paralogs for ERAL1 Gene

No data available for Paralogs for ERAL1 Gene

Variants for ERAL1 Gene

Sequence variations from dbSNP and Humsavar for ERAL1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2242345 -- 28,858,809(-) TTCAC(A/G)TCCTC reference, synonymous-codon
rs4795468 -- 28,857,264(+) CACCA(C/T)GCCCG intron-variant
rs11867794 -- 28,857,661(+) gtggt(A/G)cacgc intron-variant
rs34393976 -- 28,859,348(+) AGCTT(-/G)GGAGC intron-variant
rs34484905 -- 28,857,877(+) TCTCT(-/C)CTGAC intron-variant

Variation tolerance for ERAL1 Gene

Residual Variation Intolerance Score: 47.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ERAL1 Gene

HapMap Linkage Disequilibrium report
ERAL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ERAL1 Gene

Disorders for ERAL1 Gene

Relevant External Links for ERAL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ERAL1

No disorders were found for ERAL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERAL1 Gene

Publications for ERAL1 Gene

  1. Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit. (PMID: 20604745) Dennerlein S. … Lightowlers R.N. (Biochem. J. 2010) 2 3 4 67
  2. Mammalian homologue of E. coli Ras-like GTPase (ERA) is a possible apoptosis regulator with RNA binding activity. (PMID: 11733036) Akiyama T. … Inoue J. (Genes Cells 2001) 3 23
  3. Isolation and preliminary characterization of the human and mouse homologues of the bacterial cell cycle gene era. (PMID: 10945472) Britton R.A. … Lupski J.R. (Genomics 2000) 2 3
  4. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ERAL1 Gene

Sources for ERAL1 Gene

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