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ERAL1 Gene

protein-coding   GIFtS: 55
GCID: GC17P027182

Era-Like 12S Mitochondrial RRNA Chaperone 1

(Previous names: Era (E. coli G-protein homolog)-like 1, Era G-protein-like...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Era-Like 12S Mitochondrial RRNA Chaperone 11 2     ERA2
Era (E. Coli G-Protein Homolog)-Like 11 2     ERAL1A2
Conserved ERA-Like GTPase2 3     HERA-A2
CEGA2 3     HERA-B2
ERA-W2 3     Era G-Protein-Like 12
H-ERA2 3     GTP-Binding Protein Era Homolog2
ERA-Like Protein 12 3     GTPase Era, Mitochondrial2
hERA2 3     GTPase, Human Homolog Of E. Coli Essential Cell Cycle Protein Era2
Era G-Protein-Like 1 (E. Coli)1     HERA3

External Ids:    HGNC: 34241   Entrez Gene: 262842   Ensembl: ENSG000001325917   OMIM: 6074355   UniProtKB: O756163   

Export aliases for ERAL1 gene to outside databases

Previous GC identifers: GC17P027027 GC17P029081 GC17P027327 GC17P024206 GC17P023390


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ERAL1 Gene:
ERAL1 (Era-like 12S mitochondrial rRNA chaperone 1) is a protein-coding gene. GO annotations related to this gene include RNA binding and rRNA binding.

UniProtKB/Swiss-Prot: ERAL1_HUMAN, O75616
Function: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically
binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop
region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal
small subunit assembly




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ERAL1 gene promoter:
         ER-alpha   AREB6   C/EBPbeta   p53   AML1a   CUTL1   ZIC2/Zic2   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidERAL1 promoter sequence
   Search Chromatin IP Primers for ERAL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ERAL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

ERAL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ERAL1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P027182:  view genomic region     (about GC identifiers)

Start:
27,181,956 bp from pter      End:
27,188,085 bp from pter
Size:
6,130 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ERAL1_HUMAN, O75616 (See protein sequence)
Recommended Name: GTPase Era, mitochondrial precursor  
Size: 437 amino acids; 48350 Da
Sequence caution: Sequence=AAG12978.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KN21 C9JEC6 O75617 Q8WUY4 Q96LE2 Q96TC0
Alternative splicing: 2 isoforms:  O75616-1   O75616-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ERAL1: NX_O75616

Explore proteomics data for ERAL1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys393, Lys398
  • Modification sites at PhosphoSitePlus

  • See ERAL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005693.1  
    ENSEMBL proteins: 
     ENSP00000254928   ENSP00000396125   ENSP00000464607   ENSP00000464402   ENSP00000467860  

    ERAL1 Human Recombinant Protein Products:

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    Novus Biologicals ERAL1 Lysates
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    Cloud-Clone Corp. Proteins for ERAL1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR009019 KH_prok-type
     IPR005662 GTP-bd_Era
     IPR005225 Small_GTP-bd_dom
     IPR027417 P-loop_NTPase
     IPR006073 GTP_binding_domain

    Graphical View of Domain Structure for InterPro Entry O75616

    ProtoNet protein and cluster: O75616

    2 Blocks protein domains:
    IPB002917 GTP-binding protein
    IPB006073 GTP1/OBG GTP-binding protein family signature


    UniProtKB/Swiss-Prot: ERAL1_HUMAN, O75616
    Similarity: Belongs to the Era/MnmE GTP-binding protein family. Era subfamily
    Similarity: Contains 1 G (guanine nucleotide-binding) domain
    Similarity: Contains 1 KH type-2 domain


    Find genes that share domains with ERAL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ERAL1_HUMAN, O75616
    Function: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically
    binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop
    region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal
    small subunit assembly

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0003924GTPase activity ----
    GO:0005525GTP binding IEA--
    GO:0015093ferrous iron transmembrane transporter activity ----
    GO:0019843rRNA binding IDA--
         
    Find genes that share ontologies with ERAL1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ERAL1:
     Decreased cilium length  Decreased cilium length after   Increased gamma-H2AX phosphory 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target ERAL1:
    hsa-mir-361-5p (MIRT044074), hsa-mir-149-5p (MIRT045561)

    Block miRNA regulation of human, mouse, rat ERAL1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate ERAL1:
    hsa-miR-1266 hsa-miR-610 hsa-miR-3125 hsa-miR-3916 hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidERAL1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ERAL1

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    GenScript: all cDNA clones in your preferred vector: ERAL1 (NM_005702)
    Sino Biological Human cDNA Clone for ERAL1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ERAL1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERAL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ERAL1_HUMAN, O75616: Mitochondrion matrix. Mitochondrion inner membrane; Peripheral membrane protein.
    Note=Localizes on the matrix side on the mitochondrial inner membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    peroxisome2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005759mitochondrial matrix IDA--

    Find genes that share ontologies with ERAL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ERAL1 About    
    See pathways by source

    SuperPathContained pathways About
    1Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway


    1 BioSystems Pathway for ERAL1
        Integrated Breast Cancer Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ERAL1
    Interactions:

        Search GeneGlobe Interaction Network for ERAL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for ERAL1 (O756162, 3 ENSP000002549284) via UniProtKB, MINT, STRING, and/or I2D (see all 809)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    LONP1P367762, ENSP000003538264MINT-8079030 STRING: ENSP00000353826
    MRPS2Q9Y3992, ENSP000002416004MINT-8079030 STRING: ENSP00000241600
    HSPD1P108092MINT-8079030 MINT-7947479
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000028ribosomal small subunit assembly IMP--
    GO:0007264small GTPase mediated signal transduction ----
    GO:0015684ferrous iron transport ----

    Find genes that share ontologies with ERAL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ERAL1

    1 HMDB Compound for ERAL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ERAL1 gene: 
    NM_005702.2  

    Unigene Cluster for ERAL1:

    Era G-protein-like 1 (E. coli)
    Hs.3426  [show with all ESTs]
    Unigene Representative Sequence: BX537542
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254928(uc002hcy.1 uc002hcz.1) ENST00000412138(uc002hcx.1)
    ENST00000578001 ENST00000461894 ENST00000580917 ENST00000577942 ENST00000471992(uc002hda.1)
    ENST00000583487
    miRNA
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    Block miRNA regulation of human, mouse, rat ERAL1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate ERAL1:
    hsa-miR-1266 hsa-miR-610 hsa-miR-3125 hsa-miR-3916 hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidERAL1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ERAL1
    Predesigned siRNA for gene silencing in human, mouse, rat ERAL1
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    GenScript: all cDNA clones in your preferred vector: ERAL1 (NM_005702)
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    Primer
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    OriGene qPCR primer pairs and template standards for ERAL1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ERAL1
      QuantiTect SYBR Green Assays in human, mouse, rat ERAL1
      QuantiFast Probe-based Assays in human, mouse, rat ERAL1

    Additional mRNA sequence: 

    AB049388.1 AF082657.1 AF082658.1 AK023342.1 AY007435.1 BC019094.2 BX537542.1 

    14 DOTS entries:

    DT.95262445  DT.453317  DT.100757764  DT.97847786  DT.120891892  DT.100885111  DT.100029293  DT.100885106 
    DT.86854990  DT.100727289  DT.120891874  DT.120891915  DT.91760690  DT.91760692 

    Selected AceView cDNA sequences (see all 401):

    CR611953 T34378 BU520775 BE791193 BM693280 CR609444 BM842728 CR605279 
    T32992 BM717345 BU956992 BU553826 D79048 AI720327 AA352585 BG325844 
    BQ706315 BM044451 BP350163 CR614207 AA349546 BM843949 R19122 BQ648204 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ERAL1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10
    SP1:                          -           -     -                                                   
    SP2:                          -           -     -                       -     -                     
    SP3:                          -           -     -                                                   
    SP4:                          -     -     -     -                                                   
    SP5:                                                                                                


    ECgene alternative splicing isoforms for ERAL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ERAL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACACTGACT
    ERAL1 Expression
    About this image


    ERAL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ERAL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ERAL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.3426
        Custom PCR Arrays for ERAL1
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    QuantiFast Probe-based Assays in human, mouse, rat ERAL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ERAL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ERAL1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eral11 , 5 Era (G-protein)-like 1 (E. coli)1, 5 82.91(n)1
    78.26(a)1
      11 (46.74 cM)5
    578371  NM_022313.21  NP_071708.21 
     780733765 
    chicken
    (Gallus gallus)
    Aves ERAL11 Era G-protein-like 1 (E. coli) 61.58(n)
    58.62(a)
      374084  NM_204239.1  NP_989570.1 
    lizard
    (Anolis carolinensis)
    Reptilia ERAL16
    Era-like 12S mitochondrial rRNA chaperone 1
    70(a)
    1 ↔ 1
    GL344494.1(30310-32155)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.119032 Transcribed sequence with weak similarity to protein more 74.58(n)    CF222733.1 
    zebrafish
    (Danio rerio)
    Actinopterygii eral11 Era G-protein-like 1 (E. coli) 56.78(n)
    54.18(a)
      569087  NM_001128747.1  NP_001122219.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74881 CG7488 45.7(n)
    32.58(a)
      41597  NM_141991.3  NP_650248.1 
    worm
    (Caenorhabditis elegans)
    Secernentea E02H1.21 E02H1.2 41.15(n)
    30(a)
      174508  NM_063659.1  NP_496060.1 


    ENSEMBL Gene Tree for ERAL1 (if available)
    TreeFam Gene Tree for ERAL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ERAL1 (see all 160)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3715426401,2
    C--27180212(+) TGTCT-/AAAAAAA 1 -- us2k10--------
    rs1485257311,2
    C--27180320(+) GAGGCC/TGTAGT 1 -- us2k10--------
    rs604499321,2
    C--27180343(+) CACCAA/CTGCAC 1 -- us2k10--------
    rs1893034091,2
    --27180376(+) GACCCC/TGTCTC 1 -- us2k10--------
    rs99150531,2
    C,F,H--27180615(+) tactgT/Cattgt 1 -- us2k19Minor allele frequency- C:0.02NS EA NA WA 1190
    rs1169000051,2
    F--27180653(+) TAGAGA/GTGGGG 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs47954671,2
    C,F,A,H--27180784(+) tgtgcC/Ttgtag 1 -- us2k121Minor allele frequency- T:0.19NS EA NA WA 2328
    rs343932471,2
    C--27180960(+) GTTTC-/TTTTTT 1 -- us2k12Minor allele frequency- T:0.25NA 4
    rs1156294131,2
    --27180964(+) CTTTTC/TTTTTT 1 -- us2k10--------
    rs1817243141,2
    --27181151(+) AGAGAA/CCGGGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ERAL1 (27181956 - 27188085 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ERAL1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ERAL1
    DNA2.0 Custom Variant and Variant Library Synthesis for ERAL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607435    OMIM disorders: --


    Find genes that share disorders with ERAL1           About GenesLikeMe


    Export disorders for ERAL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ERAL1 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with ERAL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit. (PubMed id 20604745)1, 2, 3 Dennerlein S....Lightowlers R.N. (Biochem. J. 2010)
    2. Isolation and preliminary characterization of the human and mouse homologues of the bacterial cell cycle gene era. (PubMed id 10945472)1, 2, 3 Britton R.A....Lupski J.R. (Genomics 2000)
    3. Mammalian homologue of E. coli Ras-like GTPase (ERA) is a possible apoptosis regulator with RNA binding activity. (PubMed id 11733036)1, 2, 9 Akiyama T.... Inoue J. (Genes Cells 2001)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    7. p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability. (PubMed id 22904065)1 Yagi M....Kang D. (Nucleic Acids Res. 2012)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    10. Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47. (PubMed id 22354994)1 Teachenor R....Murre C. (Mol. Cell. Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26284 HGNC: 3424 AceView: ERAL1 Ensembl:ENSG00000132591 euGenes: HUgn26284
    ECgene: ERAL1 H-InvDB: ERAL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ERAL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ERAL1 gene:
    Search GeneIP for patents involving ERAL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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