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Aliases for ERAL1 Gene

Aliases for ERAL1 Gene

  • Era-Like 12S Mitochondrial RRNA Chaperone 1 2 3
  • Era (E. Coli G-Protein Homolog)-Like 1 2 3
  • Conserved ERA-Like GTPase 3 4
  • ERA-Like Protein 1 3 4
  • ERA-W 3 4
  • H-ERA 3 4
  • CEGA 3 4
  • HERA 3 4
  • GTPase, Human Homolog Of E. Coli Essential Cell Cycle Protein Era 3
  • GTP-Binding Protein Era Homolog 3
  • Era G-Protein-Like 1 (E. Coli) 2
  • GTPase Era, Mitochondrial 3
  • Era G-Protein-Like 1 3
  • ERAL1A 3
  • HERA-A 3
  • HERA-B 3
  • ERA 3

External Ids for ERAL1 Gene

Summaries for ERAL1 Gene

GeneCards Summary for ERAL1 Gene

ERAL1 (Era-Like 12S Mitochondrial RRNA Chaperone 1) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway. GO annotations related to this gene include RNA binding and rRNA binding.

UniProtKB/Swiss-Prot for ERAL1 Gene

  • Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3 terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERAL1 Gene

Genomics for ERAL1 Gene

Genomic Location for ERAL1 Gene

Start:
28,854,938 bp from pter
End:
28,861,067 bp from pter
Size:
6,130 bases
Orientation:
Plus strand

Genomic View for ERAL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ERAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERAL1 Gene

Regulatory Elements for ERAL1 Gene

Proteins for ERAL1 Gene

  • Protein details for ERAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75616-ERAL1_HUMAN
    Recommended name:
    GTPase Era, mitochondrial
    Protein Accession:
    O75616
    Secondary Accessions:
    • B3KN21
    • C9JEC6
    • O75617
    • Q8WUY4
    • Q96LE2
    • Q96TC0

    Protein attributes for ERAL1 Gene

    Size:
    437 amino acids
    Molecular mass:
    48350 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG12978.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ERAL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERAL1 Gene

Proteomics data for ERAL1 Gene at MOPED

Post-translational modifications for ERAL1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys393 and Lys398

Other Protein References for ERAL1 Gene

No data available for DME Specific Peptides for ERAL1 Gene

Domains for ERAL1 Gene

UniProtKB/Swiss-Prot:

ERAL1_HUMAN
Domain:
  • Contains 1 Era-type G (guanine nucleotide-binding) domain.:
    • O75616
  • Contains 1 KH type-2 domain.:
    • O75616
Family:
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.:
    • O75616
genes like me logo Genes that share domains with ERAL1: view

No data available for Gene Families for ERAL1 Gene

Function for ERAL1 Gene

Molecular function for ERAL1 Gene

UniProtKB/Swiss-Prot Function: Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3 terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly.

Gene Ontology (GO) - Molecular Function for ERAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0003924 GTPase activity --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
GO:0015093 ferrous iron transmembrane transporter activity --
genes like me logo Genes that share ontologies with ERAL1: view
genes like me logo Genes that share phenotypes with ERAL1: view

miRNA for ERAL1 Gene

miRTarBase miRNAs that target ERAL1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ERAL1 Gene

Localization for ERAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERAL1 Gene

Mitochondrion matrix. Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes on the matrix side on the mitochondrial inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ERAL1 Gene COMPARTMENTS Subcellular localization image for ERAL1 gene
Compartment Confidence
mitochondrion 5
cytosol 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for ERAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005759 mitochondrial matrix IDA 20604745
genes like me logo Genes that share ontologies with ERAL1: view

Pathways for ERAL1 Gene

genes like me logo Genes that share pathways with ERAL1: view

Pathways by source for ERAL1 Gene

1 BioSystems pathway for ERAL1 Gene

Gene Ontology (GO) - Biological Process for ERAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000028 ribosomal small subunit assembly IMP 20604745
GO:0007264 small GTPase mediated signal transduction --
GO:0015684 ferrous iron transport --
genes like me logo Genes that share ontologies with ERAL1: view

Compounds for ERAL1 Gene

(1) HMDB Compounds for ERAL1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with ERAL1: view

Transcripts for ERAL1 Gene

Unigene Clusters for ERAL1 Gene

Era G-protein-like 1 (E. coli):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ERAL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10
SP1: - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5:
SP6:
SP7:

Relevant External Links for ERAL1 Gene

GeneLoc Exon Structure for
ERAL1
ECgene alternative splicing isoforms for
ERAL1

Expression for ERAL1 Gene

mRNA expression in normal human tissues for ERAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ERAL1 Gene

SOURCE GeneReport for Unigene cluster for ERAL1 Gene Hs.3426

genes like me logo Genes that share expressions with ERAL1: view

Orthologs for ERAL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ERAL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ERAL1 36
  • 99.31 (n)
  • 99.08 (a)
ERAL1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ERAL1 36
  • 84.44 (n)
  • 81.24 (a)
ERAL1 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-451 37
  • 81 (a)
OneToOne
ERAL1 36
  • 85.51 (n)
  • 80.55 (a)
mouse
(Mus musculus)
Mammalia Eral1 36
  • 82.91 (n)
  • 78.26 (a)
Eral1 16
Eral1 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ERAL1 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ERAL1 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eral1 36
  • 83.06 (n)
  • 78.42 (a)
chicken
(Gallus gallus)
Aves ERAL1 36
  • 61.58 (n)
  • 58.62 (a)
ERAL1 37
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ERAL1 37
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495069 36
  • 60.25 (n)
  • 60.43 (a)
Str.11903 36
zebrafish
(Danio rerio)
Actinopterygii eral1 36
  • 56.78 (n)
  • 54.18 (a)
eral1 37
  • 45 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010622 36
  • 49.22 (n)
  • 36.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7488 36
  • 45.7 (n)
  • 32.58 (a)
CG7488 37
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea E02H1.2 36
  • 41.15 (n)
  • 30 (a)
E02H1.2 37
  • 26 (a)
OneToOne
Species with no ortholog for ERAL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ERAL1 Gene

ENSEMBL:
Gene Tree for ERAL1 (if available)
TreeFam:
Gene Tree for ERAL1 (if available)

Paralogs for ERAL1 Gene

No data available for Paralogs for ERAL1 Gene

Variants for ERAL1 Gene

Sequence variations from dbSNP and Humsavar for ERAL1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1042900 -- 28,855,078(+) ATCGG(C/T)GTTAA missense, reference
rs2242345 -- 28,858,809(-) TTCAC(A/G)TCCTC reference, synonymous-codon
rs2291486 -- 28,856,470(+) GGGAT(C/G)TGGGA intron-variant
rs4795467 -- 28,853,766(+) tgtgc(C/T)tgtag upstream-variant-2KB
rs4795468 -- 28,857,264(+) CACCA(C/T)GCCCG intron-variant

Relevant External Links for ERAL1 Gene

HapMap Linkage Disequilibrium report
ERAL1

No data available for Structural Variations from Database of Genomic Variants (DGV) for ERAL1 Gene

Disorders for ERAL1 Gene

No disorders were found for ERAL1 Gene.

No data available for UniProtKB/Swiss-Prot for ERAL1 Gene

Publications for ERAL1 Gene

  1. Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit. (PMID: 20604745) Dennerlein S. … Lightowlers R.N. (Biochem. J. 2010) 2 3 4
  2. Mammalian homologue of E. coli Ras-like GTPase (ERA) is a possible apoptosis regulator with RNA binding activity. (PMID: 11733036) Akiyama T. … Inoue J. (Genes Cells 2001) 3 4 23
  3. Isolation and preliminary characterization of the human and mouse homologues of the bacterial cell cycle gene era. (PMID: 10945472) Britton R.A. … Lupski J.R. (Genomics 2000) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman R.T. … Brenner S.E. (Genome Biol. 2004) 3 4

Products for ERAL1 Gene

Sources for ERAL1 Gene

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