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Aliases for EQTN Gene

Aliases for EQTN Gene

  • Equatorin 2 3 5
  • Acrosome Formation Associated Factor 2 3
  • Equatorin, Sperm Acrosome Associated 2 3
  • Acrosome Formation-Associated Factor 3 4
  • Sperm Acrosome Associated 8 2 3
  • C9orf11 3 4
  • AFAF 3 4
  • Chromosome 9 Open Reading Frame 11 2
  • Acr Formation Associated Factor 2
  • SPACA8 3

External Ids for EQTN Gene

Previous HGNC Symbols for EQTN Gene

  • C9orf11

Summaries for EQTN Gene

GeneCards Summary for EQTN Gene

EQTN (Equatorin) is a Protein Coding gene.

UniProtKB/Swiss-Prot for EQTN Gene

  • Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EQTN Gene

Genomics for EQTN Gene

Regulatory Elements for EQTN Gene

Enhancers for EQTN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EQTN on UCSC Golden Path with GeneCards custom track

Genomic Location for EQTN Gene

Chromosome:
9
Start:
27,284,654 bp from pter
End:
27,297,139 bp from pter
Size:
12,486 bases
Orientation:
Minus strand

Genomic View for EQTN Gene

Genes around EQTN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EQTN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EQTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EQTN Gene

Proteins for EQTN Gene

  • Protein details for EQTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ60-EQTN_HUMAN
    Recommended name:
    Equatorin
    Protein Accession:
    Q9NQ60
    Secondary Accessions:
    • B2RPB3
    • B7ZMK1
    • Q5TCU1
    • Q96L22

    Protein attributes for EQTN Gene

    Size:
    294 amino acids
    Molecular mass:
    32840 Da
    Quaternary structure:
    • Interacts with SNAP25.

    Alternative splice isoforms for EQTN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EQTN Gene

Proteomics data for EQTN Gene at MOPED

Post-translational modifications for EQTN Gene

  • Highly N- and O-glycosylated; contains sialic acid.
  • Glycosylation at Asn 76 and Asn 143
  • Modification sites at PhosphoSitePlus

Other Protein References for EQTN Gene

No data available for DME Specific Peptides for EQTN Gene

Domains & Families for EQTN Gene

Protein Domains for EQTN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EQTN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with EQTN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for EQTN Gene

Function for EQTN Gene

Molecular function for EQTN Gene

UniProtKB/Swiss-Prot Function:
Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis.
genes like me logo Genes that share phenotypes with EQTN: view

Animal Models for EQTN Gene

MGI Knock Outs for EQTN:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for EQTN Gene

Localization for EQTN Gene

Subcellular locations from UniProtKB/Swiss-Prot for EQTN Gene

Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane; Single-pass type I membrane protein. Note=In the anterior acrosome region, enriched on the inner acrosomal membrane but minimal on the outer acrosomal membrane; in contrast in the posterior acrosome region enriched on both the inner and outer acrosomal membranes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EQTN Gene COMPARTMENTS Subcellular localization image for EQTN gene
Compartment Confidence
plasma membrane 3
endosome 2
nucleus 2

Gene Ontology (GO) - Cellular Components for EQTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002079 inner acrosomal membrane ISS --
GO:0002080 acrosomal membrane IEA --
GO:0005737 cytoplasm IEA --
GO:0005769 early endosome IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EQTN: view

Pathways & Interactions for EQTN Gene

SuperPathways for EQTN Gene

No Data Available

Interacting Proteins for EQTN Gene

Gene Ontology (GO) - Biological Process for EQTN Gene

None

No data available for Pathways by source and SIGNOR curated interactions for EQTN Gene

Drugs & Compounds for EQTN Gene

No Compound Related Data Available

Transcripts for EQTN Gene

mRNA/cDNA for EQTN Gene

Unigene Clusters for EQTN Gene

Equatorin, sperm acrosome associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EQTN Gene

No ASD Table

Relevant External Links for EQTN Gene

GeneLoc Exon Structure for
EQTN
ECgene alternative splicing isoforms for
EQTN

Expression for EQTN Gene

mRNA expression in normal human tissues for EQTN Gene

mRNA differential expression in normal tissues according to GTEx for EQTN Gene

This gene is overexpressed in Testis (x41.3).

Protein differential expression in normal tissues from HIPED for EQTN Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for EQTN Gene



SOURCE GeneReport for Unigene cluster for EQTN Gene Hs.163070

mRNA Expression by UniProt/SwissProt for EQTN Gene

Q9NQ60-EQTN_HUMAN
Tissue specificity: Isoform 1 is highly expressed in testis. Isoform 2 is expressed at low levels in skin and blood.
genes like me logo Genes that share expression patterns with EQTN: view

Protein tissue co-expression partners for EQTN Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for EQTN Gene

Orthologs for EQTN Gene

This gene was present in the common ancestor of mammals.

Orthologs for EQTN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EQTN 35
  • 75.12 (n)
  • 64.18 (a)
EQTN 36
  • 55 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EQTN 35
  • 72.66 (n)
  • 58.63 (a)
EQTN 36
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eqtn 35
  • 70.96 (n)
  • 57.95 (a)
Eqtn 16
Eqtn 36
  • 47 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EQTN 35
  • 99.21 (n)
  • 98.3 (a)
EQTN 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eqtn 35
  • 73.42 (n)
  • 59.92 (a)
oppossum
(Monodelphis domestica)
Mammalia EQTN 36
  • 24 (a)
OneToOne
Species with no ortholog for EQTN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for EQTN Gene

ENSEMBL:
Gene Tree for EQTN (if available)
TreeFam:
Gene Tree for EQTN (if available)

Paralogs for EQTN Gene

No data available for Paralogs for EQTN Gene

Variants for EQTN Gene

Sequence variations from dbSNP and Humsavar for EQTN Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs12337286 - 27,292,476(+) TGCAT(C/T)GACAG intron-variant, upstream-variant-2KB, reference, missense
VAR_032137 -
rs12341576 - 27,292,448(+) CTTCA(A/G)TGGTG intron-variant, upstream-variant-2KB, reference, missense
rs911602 -- 27,290,727(-) TTGTA(G/T)TTGGA intron-variant
rs112983015 -- 27,295,311(+) GAGTT(A/T)TGAAA intron-variant

Variation tolerance for EQTN Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.93% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for EQTN Gene

Disorders for EQTN Gene

Relevant External Links for EQTN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EQTN

No disorders were found for EQTN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EQTN Gene

Publications for EQTN Gene

  1. Isolation and characterisation of a novel human gene (C9orf11) on chromosome 9p21, a region frequently deleted in human cancer. (PMID: 11118625) Ruiz A. … Estivill X. (Biochim. Biophys. Acta 2000) 3 4 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study. (PMID: 20801718) Laaksovirta H. … Traynor B.J. (Lancet Neurol 2010) 3
  4. Afaf, a novel vesicle membrane protein, is related to acrosome formation in murine testis. (PMID: 16831425) Li Y.C. … Liu Y.X. (FEBS Lett. 2006) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for EQTN Gene

Sources for EQTN Gene

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