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EPYC Gene

protein-coding   GIFtS: 53
GCID: GC12M091357

Epiphycan

(Previous names: dermatan sulphate proteoglycan 3, dermatan sulfate proteoglycan...)
(Previous symbol: DSPG3)
  See EPYC-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
epiphycan1 2     SLRR3B2 3
DSPG31 2 3 5     Dermatan Sulphate Proteoglycan 31
Dermatan Sulfate Proteoglycan 31 2 3     Pg-Lb2
Epiphycan Proteoglycan1 2     proteoglycan-lb2
Small Chondroitin/Dermatan Sulfate Proteoglycan2 3     PG-Lb3
PGLB2 3     Proteoglycan-Lb3

External Ids:    HGNC: 30531   Entrez Gene: 18332   Ensembl: ENSG000000837827   OMIM: 6016575   UniProtKB: Q996453   

Export aliases for EPYC gene to outside databases

Previous GC identifers: GC12M089881 GC12M088425


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EPYC Gene:
Dermatan sulfate proteoglycan 3 is a member of the small leucine-rich repeat proteoglycan family. This gene is
composed of seven exons. It regulates fibrillogenesis by interacting with collagen fibrils and other
extracellular matrix proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for EPYC Gene:
EPYC (epiphycan) is a protein-coding gene. Diseases associated with EPYC include posterior amorphous corneal dystrophy. GO annotations related to this gene include glycosaminoglycan binding. An important paralog of this gene is OGN.

UniProtKB/Swiss-Prot: EPYC_HUMAN, Q99645
Function: May have a role in bone formation and also in establishing the ordered structure of cartilage through
matrix organization




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the EPYC gene promoter:
         Nkx3-1   TBP   Nkx3-1 v4   Nkx3-1 v1   CUTL1   Nkx3-1 v2   SRY   S8   HFH-1   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEPYC promoter sequence
   Search Chromatin IP Primers for EPYC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EPYC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21   Ensembl cytogenetic band:  12q21.33   HGNC cytogenetic band: 12q21

EPYC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPYC gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M091357:  view genomic region     (about GC identifiers)

Start:
91,357,456 bp from pter      End:
91,398,803 bp from pter
Size:
41,348 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: EPYC_HUMAN, Q99645 (See protein sequence)
Recommended Name: Epiphycan precursor  
Size: 322 amino acids; 36637 Da
Secondary accessions: A8K3M7 Q8NEJ5

Explore the universe of human proteins at neXtProt for EPYC: NX_Q99645

Explore proteomics data for EPYC at MOPED

Post-translational modifications: 

  • The O-linked polysaccharides on Thr-60 and Ser-96 are probably the mucin type linked to GalNAc. There is one
    glycosaminoglycan chain, known to be dermatan sulfate, and it is probably the O-glycosylation at Ser-64 (By
    similarity)1
  • Glycosylation2 at Thr60, Ser64, Ser96, Asn283, Asn302
  • Modification sites at PhosphoSitePlus

  • See EPYC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004941.2  
    ENSEMBL proteins: 
     ENSP00000261172   ENSP00000448272  

    EPYC Human Recombinant Protein Products:

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    Novus Biologicals EPYC Protein
    Novus Biologicals EPYC Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EPYC

     
    Search eBioscience for Proteins for EPYC 

     
    antibodies-online proteins for EPYC (5 products) 

     
    antibodies-online peptides for EPYC

    EPYC Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for EPYC (Q99645, Q99645 )
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    Search ThermoFisher Antibodies for EPYC
    antibodies-online antibodies for EPYC (18 products) 

    EPYC Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EPYC
    Cloud-Clone Corp. CLIAs for EPYC
    Search eBioscience for ELISAs for EPYC 
    antibodies-online kits for EPYC (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLRR: Proteoglycans / Extracellular Matrix : Small leucine-rich repeats

    3 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR000372 LRR-contain_N
     IPR027217 Epiphycan

    Graphical View of Domain Structure for InterPro Entry Q99645

    ProtoNet protein and cluster: Q99645

    1 Blocks protein domain: IPB000372 Cysteine-rich flanking region

    UniProtKB/Swiss-Prot: EPYC_HUMAN, Q99645
    Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily
    Similarity: Contains 6 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRNT domain


    Find genes that share domains with EPYC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EPYC_HUMAN, Q99645
    Function: May have a role in bone formation and also in establishing the ordered structure of cartilage through
    matrix organization

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005539glycosaminoglycan binding TAS8975717
         
    Find genes that share ontologies with EPYC           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for EPYC

    miRNA
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    Block miRNA regulation of human, mouse, rat EPYC using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate EPYC
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat EPYC

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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EPYC (NM_004950)
    Sino Biological Human cDNA Clone for EPYC
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPYC

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for EPYC 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPYC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EPYC_HUMAN, Q99645: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytosol1
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--

    Find genes that share ontologies with EPYC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EPYC (see all 13)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EPYC
    Interactions:

        Search GeneGlobe Interaction Network for EPYC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for EPYC (ENSP000002611724) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BOCENSP000003475464STRING: ENSP00000347546
    LRRTM1ENSP000002950574STRING: ENSP00000295057
    PDGFRLENSP000002516304STRING: ENSP00000251630
    FGFRL1ENSP000002647484STRING: ENSP00000264748
    CAB39ENSP000002584184STRING: ENSP00000258418
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007565female pregnancy TAS8975717

    Find genes that share ontologies with EPYC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EPYC



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EPYC gene: 
    NM_004950.4  

    Unigene Cluster for EPYC:

    Epiphycan
    Hs.435680  [show with all ESTs]
    Unigene Representative Sequence: BC030958
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261172(uc001tbk.3) ENST00000551767 ENST00000550203
    miRNA
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    Block miRNA regulation of human, mouse, rat EPYC using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate EPYC
    SwitchGear 3'UTR luciferase reporter plasmidEPYC 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for EPYC
    Predesigned siRNA for gene silencing in human, mouse, rat EPYC
    Clone
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    OriGene ORF clones in mouse, rat for EPYC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EPYC (NM_004950)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPYC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPYC
    Primer
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    OriGene qPCR primer pairs and template standards for EPYC
    OriGene qSTAR qPCR primer pairs in human, mouse for EPYC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EPYC
      QuantiTect SYBR Green Assays in human, mouse, rat EPYC
      QuantiFast Probe-based Assays in human, mouse, rat EPYC

    Additional mRNA sequence: 

    AK290642.1 BC030958.1 U59111.1 

    2 DOTS entries:

    DT.409206  DT.75119242 

    Selected AceView cDNA sequences (see all 43):

    BQ006809 BQ015670 AU118100 CR598976 CR612682 AU099648 BX365045 AU117240 
    AA456742 AI276878 AU118612 BX343971 AU119962 CA412703 BC030958 CF529374 
    AL549460 BQ448017 BQ007792 BQ002814 U59111 BX343970 BF062835 NM_004950 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for EPYC    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                                                
    SP2:                                                


    ECgene alternative splicing isoforms for EPYC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EPYC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAAAAGAA
    EPYC Expression
    About this image


    EPYC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 23 entries
             Chondrocytes Zeugopod Epiphyseal End
             Zeugopod Long Bone
             HyStem+BMP4-induced 4D20.8 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 15 entries
             Mesenchymal Condensate Cells Zeugopod
             HyStem+BMP4-induced 4D20.8 cells
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Pelvic Girdle
     
     Eye (Sensory Organs)
             Periocular Mesenchyme
    EPYC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EPYC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435680

    UniProtKB/Swiss-Prot: EPYC_HUMAN, Q99645
    Tissue specificity: Cartilage, ligament, and placenta

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPYC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for EPYC gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Epyc1 , 5 epiphycan1, 5 83.95(n)1
    82.3(a)1
      10 (50.35 cM)5
    135161  NM_007884.21  NP_031910.11 
     976440685 
    chicken
    (Gallus gallus)
    Aves EPYC1 epiphycan 70.48(n)
    67.94(a)
      417890  NM_001004382.1  NP_001004382.1 
    lizard
    (Anolis carolinensis)
    Reptilia EPYC6
    epiphycan
    72(a)
    1 ↔ 1
    5(32387315-32418960)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX739544.12   -- 74.89(n)    BX739544.1 
    zebrafish
    (Danio rerio)
    Actinopterygii epyc6
    epiphycan
    21(a)
    1 ↔ 1
    4(15388347-15402128) ENSDARG00000056950


    ENSEMBL Gene Tree for EPYC (if available)
    TreeFam Gene Tree for EPYC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EPYC gene
    OGN2  OPTC2  
    2 SIMAP similar genes for EPYC using alignment to 2 protein entries:     EPYC_HUMAN (see all proteins):
    OGN    OPTC

    Find genes that share paralogs with EPYC           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EPYC (see all 945)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1388570921,2
    Cuntested191358079(+) ATCTTC/TGTGCA 2 K E mis11Minor allele frequency- T:0.00NA 4538
    rs1828403781,2
    --91357152(+) TTCAGC/TTTTGA 1 -- ds50010--------
    rs1469086011,2
    --91357200(+) AAAGAC/TGAACT 1 -- ds50010--------
    rs111058861,2
    C,F,A,H--91357349(+) TCAGCG/TCTTTA 1 -- ds500124Minor allele frequency- T:0.41NA NS EA WA CSA 2488
    rs784931581,2
    C,F--91357369(+) AAAGTT/CATAAT 1 -- ds50011Minor allele frequency- C:0.18WA 118
    rs1884129091,2
    --91357590(+) CTAAAC/GTGTTC 1 -- ut310--------
    rs779607541,2
    C,F--91357599(+) TCATTT/CCAAAA 1 -- ut311Minor allele frequency- C:0.01NA 120
    rs1177597171,2
    C,F--91357658(+) CTAAAA/GCTTGC 1 -- ut311Minor allele frequency- G:0.02NA 120
    rs30470731,2
    C--91357787(+) TTATA-/ATTA  
     T
    /TTATA
    ACATT
    2 -- ut311NA 2
    rs2020194801,2
    --91357907(+) TAGCCA/GTCGTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for EPYC (91357456 - 91398803 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for EPYC:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832483CNV Gain17160897
    nsv899425CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EPYC
    DNA2.0 Custom Variant and Variant Library Synthesis for EPYC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601657    OMIM disorders: --

    1 disease for EPYC:    
    About MalaCards
    posterior amorphous corneal dystrophy

    1 disease from the University of Copenhagen DISEASES database for EPYC:
    Myopia

    Find genes that share disorders with EPYC           About GenesLikeMe

    Genetic Association Database (GAD): EPYC
    Human Genome Epidemiology (HuGE) Navigator: EPYC (3 documents)

    Export disorders for EPYC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EPYC gene integrated from 10 sources (see top 10):
    (articles sorted by number of sources associating them with EPYC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of human DSPG3, a small dermatan sulfate proteoglycan. (PubMed id 8975717)1, 2, 3 Deere M.... Hecht J.T. (Genomics 1996)
    2. An evaluation of OPTC and EPYC as candidate genes for high myopia. (PubMed id 19844586)1, 4 Wang P....Zhang Q. (Mol. Vis. 2009)
    3. The association of haplotype at the lumican gene with high myopia susceptibility in Taiwanese patients. (PubMed id 19616852)1, 4 Chen Z.T....Lin L.L. (Ophthalmology 2009)
    4. The association of single nucleotide polymorphisms in the 5'-regulatory region of the lumican gene with susceptibility to high myopia in Taiwan. (PubMed id 16902402)1, 4 Wang I.J....Lin L.L. (Mol. Vis. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Linkage of posterior amorphous corneal dystrophy to chromosome 12q21.33 and exclusion of coding region mutations in KERA, LUM, DCN, and EPYC. (PubMed id 20357198)1 Aldave A.J....Gorin M.B. (amp 2010)
    7. Autosomal dominant cornea plana is not associated with pathogenic mutations in DCN, DSPG3, FOXC1, KERA, LUM, or PITX2. (PubMed id 17558846)1 Aldave A.J....Yellore V.S. (Ophthalmic Genet. 2007)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Genomic characterization of human DSPG3. (PubMed id 10330124)1 Deere M....Hecht J.T. (Genome Res. 1999)
    11. Molecular cloning and expression of two small leucine-rich proteoglycan (SLRP) genes, dspg3l and optcl, in zebrafish. (PubMed id 16458084)9 Zhou W....Kuwada J.Y. (Gene Expr. Patterns 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1833 HGNC: 3053 AceView: DSPG3 Ensembl:ENSG00000083782 euGenes: HUgn1833
    ECgene: EPYC H-InvDB: EPYC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EPYC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EPYC gene:
    Search GeneIP for patents involving EPYC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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