EPYC Gene

Aliases
for EPYC gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC12M089881 GC12M088425

Summaries
for EPYC gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for EPYC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000012.11  NC_018923.2  NT_029419.13  

SwitchGear Promoter luciferase reporter plasmid: EPYC promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EPYC

EPYC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M091357:  view genomic region     (about GC identifiers)

Proteins
for EPYC gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for EPYC: NX_Q99645

Explore proteomics data for EPYC at MOPED

Post-translational modifications: 

EPYC Human Recombinant Protein Products:

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	R&D Systems Recombinant & Natural Proteins for EPYC (DSPG3)
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	OriGene Purified Protein for EPYC OriGene Protein Over-expression Lysate for EPYC OriGene MassSpec for EPYC OriGene Custom Protein Services for EPYC
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	Novus Biologicals EPYC Protein Novus Biologicals EPYC Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for EPYC
	Search eBioscience for Proteins for EPYC
	Search GeneTex for Proteins for EPYC
	antibodies-online proteins for EPYC (5 products)
	antibodies-online peptides for EPYC

EPYC Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Novus Biologicals EPYC Antibodies
	Abcam antibodies for EPYC (Q99645, Q99645 )
	Cloud-Clone Corp. Antibodies for EPYC
	Search ThermoFisher Antibodies for EPYC
	antibodies-online antibodies for EPYC (18 products)

EPYC Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for EPYC Cloud-Clone Corp. CLIAs for EPYC
	Search eBioscience for ELISAs for EPYC
	antibodies-online kits for EPYC (16 products)

Domains /
Families
for EPYC gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q99645

Find genes that share domains with EPYC           About GenesLikeMe

Function
for EPYC gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for EPYC

miRNA Products:		Block miRNA regulation of human, mouse, rat EPYC using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate EPYC
		SwitchGear 3'UTR luciferase reporter plasmid: EPYC 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for EPYC
		Predesigned siRNA for gene silencing in human, mouse, rat EPYC

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for EPYC

Clone Products:		OriGene clones in human, mouse for EPYC (see all 7) OriGene ORF clones in mouse, rat for EPYC OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: EPYC (NM_004950)
		Sino Biological Human cDNA Clone for EPYC
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPYC
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPYC

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for EPYC
		Browse ESI BIO Cell Lines and PureStem Progenitors for EPYC

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPYC

Localization
for EPYC gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
extracellular	3
cytosol	1
endoplasmic reticulum	1
nucleus	1

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for EPYC gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EPYC

	MAPK Signaling
	Molecular Mechanisms of Cancer
	PTEN Pathway
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway

Gene Ontology (GO): 1 biological process term:    About this table

Drugs & Compounds
for EPYC gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for EPYC gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for EPYC gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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EPYC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAAAAAAGAA

About this image

Bone (Muscoskeletal System)    fully expand to see all 23 entries
Chondrocytes Zeugopod Epiphyseal End
Zeugopod Long Bone
HyStem+BMP4-induced 4D20.8 cells
Cartilage (Muscoskeletal System)    fully expand to see all 15 entries
Mesenchymal Condensate Cells Zeugopod
HyStem+BMP4-induced 4D20.8 cells
Neural Tube (Nervous System)    fully expand to see all 3 entries
Telencephalon
Limb (Muscoskeletal System)    fully expand to see all 2 entries
Mesenchymal Condensate Cells Zeugopod
Pelvic Girdle
Eye (Sensory Organs)
Periocular Mesenchyme

Primer Products:		OriGene qPCR primer pairs and template standards for EPYC OriGene qSTAR qPCR primer pairs in human, mouse for EPYC
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EPYC
		QuantiTect SYBR Green Assays in human, mouse, rat EPYC
		QuantiFast Probe-based Assays in human, mouse, rat EPYC

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPYC

Orthologs
for EPYC gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for EPYC gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for EPYC gene

OGN²  OPTC²  

2 SIMAP similar genes for EPYC using alignment to 2 protein entries:     EPYC_HUMAN (see all proteins):

OGN    OPTC

Find genes that share paralogs with EPYC           About GenesLikeMe

Genomic Variants
for EPYC gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for EPYC (see all 945)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1388570921,2	C	untested1	91358079(+)	ATCTTC/TGTGCA	2	K E	mis1		1		NA	4538
rs1828403781,2		--	91357152(+)	TTCAGC/TTTTGA	1	--	ds5001		0	--	--	--	--
rs1469086011,2		--	91357200(+)	AAAGAC/TGAACT	1	--	ds5001		0	--	--	--	--
rs111058861,2	C,F,A,H	--	91357349(+)	TCAGCG/TCTTTA	1	--	ds5001		24		NA NS EA WA CSA	2488
rs784931581,2	C,F	--	91357369(+)	AAAGTT/CATAAT	1	--	ds5001		1		WA	118
rs1884129091,2		--	91357590(+)	CTAAAC/GTGTTC	1	--	ut31		0	--	--	--	--
rs779607541,2	C,F	--	91357599(+)	TCATTT/CCAAAA	1	--	ut31		1		NA	120
rs1177597171,2	C,F	--	91357658(+)	CTAAAA/GCTTGC	1	--	ut31		1		NA	120
rs30470731,2	C	--	91357787(+)	TTATA-/ATTA    T/TTATAACATT	2	--	ut31		1		NA	2
rs2020194801,2		--	91357907(+)	TAGCCA/GTCGTA	1	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for EPYC (91357456 - 91398803 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for EPYC:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv832483	CNV	Gain	17160897
nsv899425	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing EPYC

DNA2.0 Custom Variant and Variant Library Synthesis for EPYC

Disorders / Diseases
for EPYC gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for EPYC gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Characterization of human DSPG3, a small dermatan sulfate proteoglycan. (PubMed id 8975717)^{1, 2, 3} Deere M.... Hecht J.T. (Genomics 1996)
2. An evaluation of OPTC and EPYC as candidate genes for high myopia. (PubMed id 19844586)^{1, 4} Wang P....Zhang Q. (Mol. Vis. 2009)
3. The association of haplotype at the lumican gene with high myopia susceptibility in Taiwanese patients. (PubMed id 19616852)^{1, 4} Chen Z.T....Lin L.L. (Ophthalmology 2009)
4. The association of single nucleotide polymorphisms in the 5'-regulatory region of the lumican gene with susceptibility to high myopia in Taiwan. (PubMed id 16902402)^{1, 4} Wang I.J....Lin L.L. (Mol. Vis. 2006)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
6. Linkage of posterior amorphous corneal dystrophy to chromosome 12q21.33 and exclusion of coding region mutations in KERA, LUM, DCN, and EPYC. (PubMed id 20357198)¹ Aldave A.J....Gorin M.B. (amp 2010)
7. Autosomal dominant cornea plana is not associated with pathogenic mutations in DCN, DSPG3, FOXC1, KERA, LUM, or PITX2. (PubMed id 17558846)¹ Aldave A.J....Yellore V.S. (Ophthalmic Genet. 2007)
8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (Nat. Genet. 2004)
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
10. Genomic characterization of human DSPG3. (PubMed id 10330124)¹ Deere M....Hecht J.T. (Genome Res. 1999)

External Searches for EPYC gene

Genome Databases showing EPYC gene

Other Databases showing EPYC gene

Specialized Databases showing EPYC gene

Products
for EPYC gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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