Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

EPYC Gene

protein-coding GIFtS: 53
GCID: GC12M091357

Epiphycan

(Previous names: dermatan sulphate proteoglycan 3, dermatan sulfate proteoglycan...)
(Previous symbol: DSPG3)

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
epiphycan¹ ²		SLRR3B² ³
DSPG3¹ ² ³ ⁵		Dermatan Sulphate Proteoglycan 3¹
Dermatan Sulfate Proteoglycan 3¹ ² ³		Pg-Lb²
Epiphycan Proteoglycan¹ ²		proteoglycan-lb²
Small Chondroitin/Dermatan Sulfate Proteoglycan² ³		PG-Lb³
PGLB² ³		Proteoglycan-Lb³

External Ids:	HGNC: 3053¹	Entrez Gene: 1833²	Ensembl: ENSG00000083782⁷	OMIM: 601657⁵	UniProtKB: Q99645³

Export aliases for EPYC gene to outside databases

Previous GC identifers: GC12M089881 GC12M088425

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for EPYC Gene:

Dermatan sulfate proteoglycan 3 is a member of the small leucine-rich repeat proteoglycan family. This gene is

composed of seven exons. It regulates fibrillogenesis by interacting with collagen fibrils and other

extracellular matrix proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for EPYC Gene:

EPYC (epiphycan) is a protein-coding gene. Diseases associated with EPYC include posterior amorphous corneal dystrophy, and corneal dystrophy. GO annotations related to this gene include glycosaminoglycan binding. An important paralog of this gene is OGN.

UniProtKB/Swiss-Prot: EPYC_HUMAN, Q99645

Function: May have a role in bone formation and also in establishing the ordered structure of cartilage through

matrix organization

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

RefSeq DNA sequence:

NC_000012.12 NC_018923.2 NT_029419.13

Regulatory elements:

Regulatory transcription factor binding sites in the EPYC gene promoter:
Nkx3-1 TBP Nkx3-1 v4 Nkx3-1 v1 CUTL1 Nkx3-1 v2 SRY S8 HFH-1 Nkx3-1 v3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EPYC promoter sequence

Search Chromatin IP Primers for EPYC

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EPYC

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21 Ensembl cytogenetic band: 12q21.33 HGNC cytogenetic band: 12q21

EPYC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPYC gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M091357: view genomic region (about GC identifiers)

Start:	91,357,456 bp from pter	End:	91,398,803 bp from pter
Size:	41,348 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: EPYC_HUMAN, Q99645 (See protein sequence)

Recommended Name: Epiphycan precursor

Size: 322 amino acids; 36637 Da

Secondary accessions: A8K3M7 Q8NEJ5

Explore the universe of human proteins at neXtProt for EPYC: NX_Q99645

Explore proteomics data for EPYC at MOPED

Post-translational modifications:

The O-linked polysaccharides on Thr-60 and Ser-96 are probably the mucin type linked to GalNAc. There is one

glycosaminoglycan chain, known to be dermatan sulfate, and it is probably the O-glycosylation at Ser-64 (By

similarity)¹

Glycosylation² at Thr60, Ser64, Ser96, Asn283, Asn302

Modification sites at PhosphoSitePlus

See EPYC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_004941.2

ENSEMBL proteins:

ENSP00000261172 ENSP00000448272

EPYC Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for EPYC (DSPG3)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for EPYC OriGene Protein Over-expression Lysate for EPYC OriGene MassSpec for EPYC OriGene Custom Protein Services for EPYC
	GenScript Custom Purified and Recombinant Proteins Services for EPYC
	Novus Biologicals EPYC Protein Novus Biologicals EPYC Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for EPYC

EPYC Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for EPYC (DSPG3)
	Browse OriGene Antibodies OriGene Custom Antibody Services for EPYC
	Novus Biologicals EPYC Antibodies
	Abcam antibodies for EPYC (Q99645, Q99645 )
	Cloud-Clone Corp. Antibodies for EPYC
	Search ThermoFisher Antibodies for EPYC
	LSBio Antibodies in human, mouse, rat for EPYC

EPYC Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for EPYC
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for EPYC
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for EPYC Cloud-Clone Corp. CLIAs for EPYC

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

HGNC Gene Families:

SLRR: Proteoglycans / Extracellular Matrix : Small leucine-rich repeats

3 InterPro protein domains:

IPR001611 Leu-rich_rpt

IPR000372 LRR-contain_N

IPR027217 Epiphycan

Graphical View of Domain Structure for InterPro Entry Q99645

ProtoNet protein and cluster: Q99645

1 Blocks protein domain: IPB000372 Cysteine-rich flanking region

UniProtKB/Swiss-Prot: EPYC_HUMAN, Q99645

Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily

Similarity: Contains 6 LRR (leucine-rich) repeats

Similarity: Contains 1 LRRNT domain

EPYC for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

UniProtKB/Swiss-Prot Summary: EPYC_HUMAN, Q99645

Function: May have a role in bone formation and also in establishing the ordered structure of cartilage through

matrix organization

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--
GO:0005539	glycosaminoglycan binding	TAS	8975717

EPYC for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EPYC

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EPYC

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EPYC

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EPYC

miRNA Products:		Block miRNA regulation of human, mouse, rat EPYC using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate EPYC
		SwitchGear 3'UTR luciferase reporter plasmid: EPYC 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for EPYC
		Predesigned siRNA for gene silencing in human, mouse, rat EPYC

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for EPYC

Clone Products:		OriGene clones in human, mouse for EPYC (see all 7) OriGene ORF clones in mouse, rat for EPYC OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: EPYC (NM_004950)
		Sino Biological Human cDNA Clone for EPYC
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPYC
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPYC

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for EPYC
		Browse ESI BIO Cell Lines and PureStem Progenitors for EPYC

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPYC

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot

EPYC_HUMAN, Q99645: Secreted, extracellular space, extracellular matrix (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	3
cytosol	1
endoplasmic reticulum	1
nucleus	1

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	IEA	--

EPYC for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EPYC (see all 13)

	MAPK Signaling
	Molecular Mechanisms of Cancer
	PTEN Pathway
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for EPYC
Interactions:

Search GeneGlobe Interaction Network for EPYC

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

Selected Interacting proteins for EPYC (ENSP00000261172⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BOC	ENSP00000347546⁴	STRING: ENSP00000347546
LRRTM1	ENSP00000295057⁴	STRING: ENSP00000295057
PDGFRL	ENSP00000251630⁴	STRING: ENSP00000251630
FGFRL1	ENSP00000264748⁴	STRING: ENSP00000264748
CAB39	ENSP00000258418⁴	STRING: ENSP00000258418

About this table

Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007565	female pregnancy	TAS	8975717

EPYC for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for EPYC

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for EPYC gene:

NM_004950.4

Unigene Cluster for EPYC:

Epiphycan

Hs.435680 [show with all ESTs]

Unigene Representative Sequence: BC030958

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000261172(uc001tbk.3) ENST00000551767 ENST00000550203

miRNA Products:		Block miRNA regulation of human, mouse, rat EPYC using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate EPYC
		SwitchGear 3'UTR luciferase reporter plasmid: EPYC 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for EPYC
		Predesigned siRNA for gene silencing in human, mouse, rat EPYC

Clone Products:		OriGene clones in human, mouse for EPYC (see all 7) OriGene ORF clones in mouse, rat for EPYC OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: EPYC (NM_004950)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPYC
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPYC

Primer Products:		OriGene qPCR primer pairs and template standards for EPYC OriGene qSTAR qPCR primer pairs in human, mouse for EPYC
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat EPYC
		QuantiTect SYBR Green Assays in human, mouse, rat EPYC
		QuantiFast Probe-based Assays in human, mouse, rat EPYC

Additional mRNA sequence:

AK290642.1 BC030958.1 U59111.1

2 DOTS entries:

DT.409206 DT.75119242

Selected AceView cDNA sequences (see all 43):

BQ006809 BQ015670 AU118100 CR598976 CR612682 AU099648 BX365045 AU117240

AA456742 AI276878 AU118612 BX343971 AU119962 CA412703 BC030958 CF529374

AL549460 BQ448017 BQ007792 BQ002814 U59111 BX343970 BF062835 NM_004950

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for EPYC About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7
SP1:
SP2:

ECgene alternative splicing isoforms for EPYC

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

EPYC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAAAAAAGAA

About this image

EPYC expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 9) fully expand


Bone (Muscoskeletal System) fully expand to see all 23 entries
Chondrocytes Zeugopod Epiphyseal End
Zeugopod Long Bone
HyStem+BMP4-induced 4D20.8 cells

Cartilage (Muscoskeletal System) fully expand to see all 15 entries
Mesenchymal Condensate Cells Zeugopod
HyStem+BMP4-induced 4D20.8 cells

Neural Tube (Nervous System) fully expand to see all 3 entries
Telencephalon

Limb (Muscoskeletal System) fully expand to see all 2 entries
Mesenchymal Condensate Cells Zeugopod
Pelvic Girdle

Eye (Sensory Organs)
Periocular Mesenchyme

EPYC Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

EPYC Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.435680

UniProtKB/Swiss-Prot: EPYC_HUMAN, Q99645

Tissue specificity: Cartilage, ligament, and placenta

Custom PCR Arrays for EPYC

Primer Products:		OriGene qPCR primer pairs and template standards for EPYC OriGene qSTAR qPCR primer pairs in human, mouse for EPYC
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat EPYC
		QuantiTect SYBR Green Assays in human, mouse, rat EPYC
		QuantiFast Probe-based Assays in human, mouse, rat EPYC

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPYC

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of chordates.

Orthologs for EPYC gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Epyc^{1 , 5}	epiphycan^{1, 5}	83.95(n)¹ 82.3(a)¹		10 (50.35 cM)⁵ 13516¹ NM_007884.2¹ NP_031910.1¹ 97644068⁵
chicken (Gallus gallus)	Aves	EPYC¹	epiphycan	70.48(n) 67.94(a)		417890 NM_001004382.1 NP_001004382.1
lizard (Anolis carolinensis)	Reptilia	EPYC⁶	epiphycan	72(a)	1 ↔ 1	5(32387315-32418960)
tropical clawed frog (Xenopus tropicalis)	Amphibia	BX739544.1²	--	74.89(n)		BX739544.1
zebrafish (Danio rerio)	Actinopterygii	epyc⁶	epiphycan	21(a)	1 ↔ 1	4(15388347-15402128) ENSDARG00000056950

ENSEMBL Gene Tree for EPYC (if available)
TreeFam Gene Tree for EPYC (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for EPYC gene

OGN² OPTC²

2 SIMAP similar genes for EPYC using alignment to 2 protein entries: EPYC_HUMAN (see all proteins):

OGN OPTC

EPYC for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs138857092^1,2	C	untested¹	91358079(+)	`ATCTTC/TGTGCA`	2	K E	mis¹		1		NA	4538
rs182840378^1,2		--	91357152(+)	`TTCAGC/TTTTGA`	1	--	ds500¹		0	--	--	--	--
rs146908601^1,2		--	91357200(+)	`AAAGAC/TGAACT`	1	--	ds500¹		0	--	--	--	--
rs11105886^1,2	C,F,A,H	--	91357349(+)	`TCAGCG/TCTTTA`	1	--	ds500¹		24		NA NS EA WA CSA	2488
rs78493158^1,2	C,F	--	91357369(+)	`AAAGTT/CATAAT`	1	--	ds500¹		1		WA	118
rs188412909^1,2		--	91357590(+)	`CTAAAC/GTGTTC`	1	--	ut3¹		0	--	--	--	--
rs77960754^1,2	C,F	--	91357599(+)	`TCATTT/CCAAAA`	1	--	ut3¹		1		NA	120
rs117759717^1,2	C,F	--	91357658(+)	`CTAAAA/GCTTGC`	1	--	ut3¹		1		NA	120
rs3047073^1,2	C	--	91357787(+)	`TTATA-/ATTA T/TTATAACATT`	2	--	ut3¹		1		NA	2
rs202019480^1,2		--	91357907(+)	`TAGCCA/GTCGTA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for EPYC (91357456 - 91398803 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for EPYC: About this table

Variant ID	Type	Subtype	PubMed ID
nsv832483	CNV	Gain	17160897
nsv899425	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing EPYC

DNA2.0 Custom Variant and Variant Library Synthesis for EPYC

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

OMIM gene information: 601657 OMIM disorders: --

7 diseases for EPYC:
About MalaCards

posterior amorphous corneal dystrophy corneal dystrophy gastroenteritis myopia

meningitis cervicitis cerebritis

1 disease from the University of Copenhagen DISEASES database for EPYC:

Myopia

EPYC for disorders About GeneDecksing

Genetic Association Database (GAD): EPYC
Human Genome Epidemiology (HuGE) Navigator: EPYC (3 documents)

Export disorders for EPYC gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for EPYC gene, integrated from 10 sources (see all 11):
(articles sorted by number of sources associating them with EPYC)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of human DSPG3, a small dermatan sulfate proteoglycan. (PubMed id 8975717)^{1, 2, 3} Deere M.... Hecht J.T. (Genomics 1996)
An evaluation of OPTC and EPYC as candidate genes for high myopia. (PubMed id 19844586)^{1, 4} Wang P....Zhang Q. (Mol. Vis. 2009)
The association of haplotype at the lumican gene with high myopia susceptibility in Taiwanese patients. (PubMed id 19616852)^{1, 4} Chen Z.T....Lin L.L. (Ophthalmology 2009)
The association of single nucleotide polymorphisms in the 5'-regulatory region of the lumican gene with susceptibility to high myopia in Taiwan. (PubMed id 16902402)^{1, 4} Wang I.J....Lin L.L. (Mol. Vis. 2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Linkage of posterior amorphous corneal dystrophy to chromosome 12q21.33 and exclusion of coding region mutations in KERA, LUM, DCN, and EPYC. (PubMed id 20357198)¹ Aldave A.J....Gorin M.B. (amp 2010)
Autosomal dominant cornea plana is not associated with pathogenic mutations in DCN, DSPG3, FOXC1, KERA, LUM, or PITX2. (PubMed id 17558846)¹ Aldave A.J....Yellore V.S. (Ophthalmic Genet. 2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (Nat. Genet. 2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
Genomic characterization of human DSPG3. (PubMed id 10330124)¹ Deere M....Hecht J.T. (Genome Res. 1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 1833	HGNC: 3053	AceView: DSPG3	Ensembl:ENSG00000083782	euGenes: HUgn1833
ECgene: EPYC	H-InvDB: EPYC

(According to HUGE)
About This Section

TryGeneCards Plus

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for EPYC	Pharmacogenomics, SNPs, Pathways

Intellectual Property for EPYC gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for EPYC gene:
Search GeneIP for patents involving EPYC

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus


	EMD Millipore genomic analysis products

	Antibodies for EPYC (DSPG3)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Recombinant/Natural Proteins for EPYC (DSPG3)		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for EPYC
	OriGene qPCR primer pairs and template standards for EPYC		OriGene Protein Over-expression Lysate for EPYC
	OriGene MassSpec something-or-other for EPYC		OriGene clones in human, mouse for EPYC
	OriGene qSTAR qPCR primer pairs in human, mouse for EPYC		OriGene Purified Protein for EPYC
	OriGene ORF clones in mouse, rat for EPYC		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for EPYC		OriGene Custom Protein Services for EPYC

	Block miRNA regulation of human, mouse, rat EPYC using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing EPYC
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EPYC		Predesigned siRNA for gene silencing in human, mouse, rat EPYC
	QuantiFast Probe-based Assays in human, mouse, rat EPYC		QuantiTect SYBR Green Assays in human, mouse, rat EPYC
	Custom PCR Arrays for EPYC		Search Chromatin IP Primers for EPYC
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat EPYC		Search GeneGlobe Interaction Network for EPYC
	Regulatory tfbs in EPYC promoter

	GenScript Custom Purified and Recombinant Proteins Services for EPYC		GenScript cDNA clones with any tag delivered in your preferred vector for EPYC
	GenScript Custom Assay Services for EPYC		GenScript Custom overexpressing Cell Line Services for EPYC
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for EPYC

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	cDNA Clones for EPYC
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	EPYC antibodies
	EPYC proteins
	EPYC lysates

	Antibodies for EPYC
	See all of Abcam's Antibodies, Kits and Proteins for EPYC
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for EPYC
	Antibodies for EPYC
	ELISAs for EPYC
	CLIAs for EPYC

Browse ESI BIO Cell Lines and PureStem Progenitors for EPYC

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPYC

	SwitchGear 3'UTR luciferase reporter plasmids for EPYC
	SwitchGear Promoter luciferase reporter plasmids for EPYC

Search ThermoFisher Antibodies for EPYC

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPYC

	inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EPYC
	inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EPYC

LSBio Antibodies in human, mouse, rat for EPYC

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

Browse compounds at ApexBio

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes EPYC gene at Home site.

Version: 3.12.142 28 July 2014
hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

EPYC Gene

Epiphycan

Aliases
for EPYC gene

Summaries
for EPYC gene

Genomic Views
for EPYC gene

Proteins
for EPYC gene

EPYC Human Recombinant Protein Products:

EPYC Antibody Products:

EPYC Assay Products:

Domains /
Families
for EPYC gene

Function
for EPYC gene

Localization
for EPYC gene

Pathways & Interactions
for EPYC gene

Drugs & Compounds
for EPYC gene

Transcripts
for EPYC gene

Expression
for EPYC gene

Orthologs
for EPYC gene

Paralogs
for EPYC gene

Genomic Variants
for EPYC gene

Disorders / Diseases
for EPYC gene

Publications
for EPYC gene

External Searches for EPYC gene

Genome Databases showing EPYC gene

Other Databases showing EPYC gene

Specialized Databases showing EPYC gene

Intellectual Property
for EPYC gene

Products
for EPYC gene

View Random Gene

GeneCards Plus

Advanced Search

Export list of displayed genes

EPYC Gene

Epiphycan

Aliasesfor EPYC gene

Summariesfor EPYC gene

Genomic Viewsfor EPYC gene

Proteinsfor EPYC gene

EPYC Human Recombinant Protein Products:

EPYC Antibody Products:

EPYC Assay Products:

Domains /Familiesfor EPYC gene

Functionfor EPYC gene

Localizationfor EPYC gene

Pathways & Interactionsfor EPYC gene

Drugs & Compoundsfor EPYC gene

Transcriptsfor EPYC gene

Expression for EPYC gene

Orthologsfor EPYC gene

Paralogsfor EPYC gene

Genomic Variantsfor EPYC gene

Disorders / Diseasesfor EPYC gene

Publicationsfor EPYC gene

External Searches for EPYC gene

Genome Databases showing EPYC gene

Other Databases showing EPYC gene

Specialized Databases showing EPYC gene

Intellectual Propertyfor EPYC gene

Productsfor EPYC gene

View Random Gene

Aliases
for EPYC gene

Summaries
for EPYC gene

Genomic Views
for EPYC gene

Proteins
for EPYC gene

Domains /
Families
for EPYC gene

Function
for EPYC gene

Localization
for EPYC gene

Pathways & Interactions
for EPYC gene

Drugs & Compounds
for EPYC gene

Transcripts
for EPYC gene

Expression
for EPYC gene

Orthologs
for EPYC gene

Paralogs
for EPYC gene

Genomic Variants
for EPYC gene

Disorders / Diseases
for EPYC gene

Publications
for EPYC gene

Intellectual Property
for EPYC gene

Products
for EPYC gene