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Aliases for EPYC Gene

Aliases for EPYC Gene

  • Epiphycan 2 3
  • Dermatan Sulfate Proteoglycan 3 2 3 4
  • DSPG3 3 4 6
  • Small Chondroitin/Dermatan Sulfate Proteoglycan 3 4
  • Epiphycan Proteoglycan 2 3
  • Proteoglycan-Lb 3 4
  • SLRR3B 3 4
  • Pg-Lb 3 4
  • PGLB 3 4
  • Dermatan Sulphate Proteoglycan 3 2

External Ids for EPYC Gene

Previous HGNC Symbols for EPYC Gene

  • DSPG3

Previous GeneCards Identifiers for EPYC Gene

  • GC12M089881
  • GC12M091357
  • GC12M088425

Summaries for EPYC Gene

Entrez Gene Summary for EPYC Gene

  • Dermatan sulfate proteoglycan 3 is a member of the small leucine-rich repeat proteoglycan family. This gene is composed of seven exons. It regulates fibrillogenesis by interacting with collagen fibrils and other extracellular matrix proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for EPYC Gene

EPYC (Epiphycan) is a Protein Coding gene. Diseases associated with EPYC include posterior amorphous corneal dystrophy and cornea plana. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include glycosaminoglycan binding. An important paralog of this gene is OGN.

UniProtKB/Swiss-Prot for EPYC Gene

  • May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPYC Gene

Genomics for EPYC Gene

Regulatory Elements for EPYC Gene

Genomic Location for EPYC Gene

Start:
90,963,679 bp from pter
End:
91,005,026 bp from pter
Size:
41,348 bases
Orientation:
Minus strand

Genomic View for EPYC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EPYC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPYC Gene

Proteins for EPYC Gene

  • Protein details for EPYC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99645-EPYC_HUMAN
    Recommended name:
    Epiphycan
    Protein Accession:
    Q99645
    Secondary Accessions:
    • A8K3M7
    • Q8NEJ5

    Protein attributes for EPYC Gene

    Size:
    322 amino acids
    Molecular mass:
    36637 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EPYC Gene

Proteomics data for EPYC Gene at MOPED

Post-translational modifications for EPYC Gene

  • The O-linked polysaccharides on Thr-60 and Ser-96 are probably the mucin type linked to GalNAc. There is one glycosaminoglycan chain, known to be dermatan sulfate, and it is probably the O-glycosylation at Ser-64 (By similarity).
  • Glycosylation at Thr60, Ser64, Ser96, Asn283, and Asn302
  • Modification sites at PhosphoSitePlus

Other Protein References for EPYC Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for EPYC Gene

Domains for EPYC Gene

Gene Families for EPYC Gene

HGNC:
  • SLRR :Proteoglycans / Extracellular Matrix : Small leucine-rich repeats

Protein Domains for EPYC Gene

Suggested Antigen Peptide Sequences for EPYC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99645

UniProtKB/Swiss-Prot:

EPYC_HUMAN :
  • Q99645
Domain:
  • Contains 1 LRRNT domain.
Family:
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
Similarity:
  • Contains 6 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with EPYC: view

Function for EPYC Gene

Molecular function for EPYC Gene

UniProtKB/Swiss-Prot Function:
May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization

Gene Ontology (GO) - Molecular Function for EPYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005539 glycosaminoglycan binding TAS 8975717
genes like me logo Genes that share ontologies with EPYC: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EPYC

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for EPYC Gene

Localization for EPYC Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPYC Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPYC Gene COMPARTMENTS Subcellular localization image for EPYC gene
Compartment Confidence
extracellular 3
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for EPYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
genes like me logo Genes that share ontologies with EPYC: view

Pathways for EPYC Gene

genes like me logo Genes that share pathways with EPYC: view

Pathways by source for EPYC Gene

Interacting Proteins for EPYC Gene

Gene Ontology (GO) - Biological Process for EPYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007565 female pregnancy TAS 8975717
genes like me logo Genes that share ontologies with EPYC: view

Transcripts for EPYC Gene

mRNA/cDNA for EPYC Gene

Unigene Clusters for EPYC Gene

Epiphycan:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EPYC

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EPYC Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2:

Relevant External Links for EPYC Gene

GeneLoc Exon Structure for
EPYC
ECgene alternative splicing isoforms for
EPYC

Expression for EPYC Gene

mRNA expression in normal human tissues for EPYC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EPYC Gene

This gene is overexpressed in Ovary (6.4), Adipose - Visceral (Omentum) (5.7), and Prostate (5.5).

Protein differential expression in normal tissues for EPYC Gene

This gene is overexpressed in Fetal heart (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for EPYC Gene

SOURCE GeneReport for Unigene cluster for EPYC Gene Hs.435680

mRNA Expression by UniProt/SwissProt for EPYC Gene

Q99645-EPYC_HUMAN
Tissue specificity: Cartilage, ligament, and placenta.
genes like me logo Genes that share expressions with EPYC: view

Expression partners for EPYC Gene

In Situ Assay Products

Orthologs for EPYC Gene

This gene was present in the common ancestor of chordates.

Orthologs for EPYC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EPYC 35
  • 90.65 (n)
  • 93.15 (a)
EPYC 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EPYC 35
  • 89.79 (n)
  • 94.06 (a)
EPYC 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Epyc 35
  • 83.95 (n)
  • 82.3 (a)
Epyc 16
Epyc 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EPYC 35
  • 99.59 (n)
  • 99.38 (a)
EPYC 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Epyc 35
  • 83.95 (n)
  • 82.3 (a)
oppossum
(Monodelphis domestica)
Mammalia EPYC 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EPYC 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves EPYC 35
  • 70.48 (n)
  • 67.94 (a)
EPYC 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EPYC 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia epyc 35
  • 68.99 (n)
  • 67.41 (a)
zebrafish
(Danio rerio)
Actinopterygii epyc 36
  • 21 (a)
OneToOne
Species with no ortholog for EPYC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EPYC Gene

ENSEMBL:
Gene Tree for EPYC (if available)
TreeFam:
Gene Tree for EPYC (if available)

Paralogs for EPYC Gene

Paralogs for EPYC Gene

Selected SIMAP similar genes for EPYC Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with EPYC: view

Variants for EPYC Gene

Sequence variations from dbSNP and Humsavar for EPYC Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1135866 -- 90,971,864(-) CACTT(C/T)GACAT missense, reference
rs1135867 -- 90,964,283(-) CAATG(G/T)TAAAA missense, reference
rs1135869 -- 90,964,204(-) ACTCC(A/T)CAAGC synonymous-codon, reference
rs1882143 -- 90,987,104(-) TGATA(C/T)TCCTG intron-variant
rs1882145 -- 90,969,742(-) TTCAC(C/G)TGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EPYC Gene

Variant ID Type Subtype PubMed ID
nsv899425 CNV Gain 21882294
nsv832483 CNV Gain 17160897

Relevant External Links for EPYC Gene

HapMap Linkage Disequilibrium report
EPYC
Human Gene Mutation Database (HGMD)
EPYC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPYC Gene

Disorders for EPYC Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for EPYC Gene in MalaCards »

(2) Diseases for EPYC Gene including...

(1) University of Copenhagen DISEASES for EPYC Gene

Relevant External Links for EPYC

Genetic Association Database (GAD)
EPYC
Human Genome Epidemiology (HuGE) Navigator
EPYC
genes like me logo Genes that share disorders with EPYC: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for EPYC Gene

Publications for EPYC Gene

  1. Characterization of human DSPG3, a small dermatan sulfate proteoglycan. (PMID: 8975717) Deere M. … Hecht J.T. (Genomics 1996) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The association of single nucleotide polymorphisms in the 5'-regulatory region of the lumican gene with susceptibility to high myopia in Taiwan. (PMID: 16902402) Wang I.J. … Lin L.L. (Mol. Vis. 2006) 3 48
  4. The association of haplotype at the lumican gene with high myopia susceptibility in Taiwanese patients. (PMID: 19616852) Chen Z.T. … Lin L.L. (Ophthalmology 2009) 3 48
  5. An evaluation of OPTC and EPYC as candidate genes for high myopia. (PMID: 19844586) Wang P. … Zhang Q. (Mol. Vis. 2009) 3 48

Products for EPYC Gene

Sources for EPYC Gene

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