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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EPX Gene

protein-coding   GIFtS: 62
GCID: GC17P056270

Eosinophil Peroxidase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Eosinophil Peroxidase1 2     EPX-PEN2
EPO2 3     EPER3
EPP2 3     EC 1.11.18
EC 1.11.1.73 8     

External Ids:    HGNC: 34231   Entrez Gene: 82882   Ensembl: ENSG000001210537   OMIM: 1313995   UniProtKB: P116783   

Export aliases for EPX gene to outside databases

Previous GC identifers: GC17P056014 GC17P058751 GC17P056612 GC17P056744 GC17P053625 GC17P051630


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EPX Gene:
This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded precursor protein
is processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an
oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of
protozoa or parasitic worms. The gene is found in a cluster of three peroxidase genes at chromosome 17q23.
Mutations in this gene result in eosinophil peroxidase deficiency. (provided by RefSeq, Sep 2009)

GeneCards Summary for EPX Gene: 
EPX (eosinophil peroxidase) is a protein-coding gene. Diseases associated with EPX include eosinophil peroxidase deficiency, and proctitis, and among its related super-pathways are Allograft rejection. GO annotations related to this gene include peroxidase activity and heme binding. An important paralog of this gene is LPO.

UniProtKB/Swiss-Prot: PERE_HUMAN, P11678
Function: Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows
significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and
lysis

Gene Wiki entry for EPX (Eosinophil peroxidase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EPX gene promoter:
         NF-1/L   E2F-1   E2F   NRSF form 1   HNF-4alpha2   Nkx2-5   NRSF form 2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEPX promoter sequence
   Search SABiosciences Chromatin IP Primers for EPX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.1   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q23.1

EPX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPX gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P056270:  view genomic region     (about GC identifiers)

Start:
56,270,089 bp from pter      End:
56,282,535 bp from pter
Size:
12,447 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PERE_HUMAN, P11678 (See protein sequence)
Recommended Name: Eosinophil peroxidase precursor  
Size: 715 amino acids; 81040 Da
Cofactor: Binds 1 calcium ion per heterodimer (By similarity)
Cofactor: Binds 1 heme B (iron-protoporphyrin IX) covalently through ester linkages to hydroxylated methyl groups
formed auto-catalytically with hydrogen peroxide at the heme C-1 and C-5 positions. The ester linkage to Asp-232
was observed in 30% of the chains
Subunit: Tetramer of two light chains and two heavy chains
Subcellular location: Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils
Secondary accessions: Q4TVP3

Explore the universe of human proteins at neXtProt for EPX: NX_P11678

Explore proteomics data for EPX at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P11678

  • 4/6 DME Specific Peptides for EPX (P11678) (see all 6)
     RDGDRFW  PCFLAGD  LMFMQWGQ  RFQDNGRAL 

    EPX Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EPX Protein Expression
    REFSEQ proteins: NP_000493.1  
    ENSEMBL proteins: 
     ENSP00000225371  

    Human Recombinant Protein Products for EPX: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for EPX
    GenScript Custom Purified and Recombinant Proteins Services for EPX
    Novus Biologicals EPX Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EPX 


    EPX Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of EPX
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for EPX
    GenScript Custom Superior Antibodies Services for EPX
    Novus Biologicals EPX Antibodies
    Abcam antibodies for EPX
    Cloud-Clone Corp. Antibodies for EPX 
    Search ThermoFisher Antibodies for EPX
    LSBio Antibodies in human, mouse, rat for EPX 

    Assay Products for EPX: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for EPX
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for EPX
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EPX 
    Cloud-Clone Corp. CLIAs for EPX


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR010255 Haem_peroxidase
     IPR019791 Haem_peroxidase_animal_subgr
     IPR002007 Haem_peroxidase_animal

    Graphical View of Domain Structure for InterPro Entry P11678

    ProtoNet protein and cluster: P11678

    2 Blocks protein domains:
    IPB002007 Animal haem peroxidase signature
    IPB010255 Haem peroxidase


    UniProtKB/Swiss-Prot: PERE_HUMAN, P11678
    Similarity: Belongs to the peroxidase family. XPO subfamily


    EPX for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PERE_HUMAN, P11678
    Function: Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows
    significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and
    lysis
    Catalytic activity: 2 phenolic donor + H(2)O(2) = 2 phenoxyl radical of the donor + 2 H(2)O

         Genatlas biochemistry entry for EPX:
    eosinophil peroxidase

         Enzyme Numbers (IUBMB): EC 1.11.1.71 2 EC 1.11.12

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004601peroxidase activity IEA--
    GO:0020037heme binding IEA--
    GO:0046872metal ion binding IEA--
         
    EPX for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Epx):
     hematopoietic system  immune system 

    EPX for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Epxtm1Nal for EPX

       inGenious Targeting Laboratory - Custom generated mouse model solutions for EPX 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EPX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EPX 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EPX 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EPX
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate EPX:
    hsa-miR-379 hsa-miR-520f hsa-miR-298 hsa-miR-1976
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for EPX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPX

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of EPX

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for EPX (see all 5)
    OriGene ORF clones in mouse, rat for EPX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EPX (NM_000502)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPX
    Sirion Biotech Customized lentivirus for stable overexpression of EPX 
                         Customized lentivirus expression plasmids for stable overexpression of EPX 

    Cell Line
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    Search LifeMap BioReagents cell lines for EPX
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPX


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EPX About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Allograft rejection
    Asthma0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for EPX):
        Asthma


    EPX for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EPX

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for EPX (P116783 ENSP000002253714) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279863, ENSP000002743354I2D: score=1 STRING: ENSP00000274335
    PLCG1P191743, ENSP000002440074I2D: score=1 STRING: ENSP00000244007
    NCK1P163333, ENSP000002889864I2D: score=1 STRING: ENSP00000288986
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002215defense response to nematode IEA--
    GO:0006979response to oxidative stress ----
    GO:0032693negative regulation of interleukin-10 production IEA--
    GO:0032714negative regulation of interleukin-5 production IEA--
    GO:0032753positive regulation of interleukin-4 production IEA--

    EPX for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EPX for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EPX (PERE)

    10/11 HMDB Compounds for EPX (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-PhenylacetamideBenzeneacetamide (see all 10)103-81-1--
    4-Coumaryl alcohol3-(4-Hydroxyphenyl)-1-propane (see all 12)1076-38-6--
    CalciumCa (see all 2)7440-70-2--
    Cyanosulfurous acid anionCNSu;cyanosulfurous acid ----
    FormaldehydeAldeide formica (see all 16)50-00-0--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    IronArmco iron (see all 19)7439-89-6--
    L-Phenylalanine(-)-beta-Phenylalanine (see all 28)63-91-2--
    MethanolAlcool methylique (see all 23)67-56-1--

    1 DrugBank Compound for EPX    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MelatoninMEL (see all 4)73-31-4targetinhibitor18516076

    10/64 Novoseek inferred chemical compound relationships for EPX gene (see all 64)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hobr 88.2 23 2002037 (4), 1985118 (3), 16166591 (1), 8860070 (1) (see all 10)
    lte4 72.7 24 11106196 (5), 11551254 (3), 9761018 (2), 9824404 (2) (see all 8)
    fml 72.5 6 8301549 (3), 7752089 (1)
    hocl 66 9 16166591 (1), 1985118 (1), 19708016 (1), 10464338 (1) (see all 5)
    bromide 65.1 27 8860070 (2), 2154520 (2), 18516076 (2), 8825615 (1) (see all 11)
    ltc4 62.6 16 8387540 (4), 7887808 (3), 8301549 (3), 1334102 (2) (see all 7)
    cytochalasin b 62.4 36 8301549 (4), 8049081 (3), 7752089 (2), 8498524 (2) (see all 12)
    fmlp 62.1 30 9425641 (3), 8049081 (3), 9482706 (3), 17206716 (2) (see all 14)
    thiocyanate 62 8 2154520 (2), 8825615 (1), 15894800 (1), 11112545 (1) (see all 5)
    histamine 55.9 34 10380774 (4), 9186539 (3), 7514197 (3), 11015298 (3) (see all 18)

    Search CenterWatch for drugs/clinical trials and news about EPX / PERE

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EPX gene: 
    NM_000502.4  

    Unigene Cluster for EPX:

    Eosinophil peroxidase
    Hs.279259  [show with all ESTs]
    Unigene Representative Sequence: NM_000502
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000225371(uc002ivq.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EPX
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate EPX:
    hsa-miR-379 hsa-miR-520f hsa-miR-298 hsa-miR-1976
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for EPX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPX
    Clone
    Products:
         
    OriGene clones in human, mouse for EPX (see all 5)
    OriGene ORF clones in mouse, rat for EPX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EPX (NM_000502)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPX
    Sirion Biotech Customized lentivirus for stable overexpression of EPX 
                         Customized lentivirus expression plasmids for stable overexpression of EPX 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for EPX
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EPX
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPX
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPX

    Additional mRNA sequence: X14346.1 

    2 DOTS entries:

    DT.106307  DT.100742357 

    16 AceView cDNA sequences:

    BF901945 AW950277 BX953021 BX644277 NM_000502 BX280635 AL597635 AJ705406 
    T28019 X14346 W92864 AJ706023 AJ706564 AW468162 W92863 AW027066 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EPX expression in normal human tissues (normalized intensities)      EPX embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTGCTTCT
    EPX Expression
    About this image


    EPX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow
             bone marrow   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Eosinophils Peripheral Blood
             bone marrow   
     
     Thymus (Hematopoietic System)

    See EPX Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EPX

    SOURCE GeneReport for Unigene cluster: Hs.279259
        SABiosciences Expression via Pathway-Focused PCR Arrays including EPX: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Allergy & Asthma in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for EPX
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EPX
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPX
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPX
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for EPX gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Epx1 , 5 eosinophil peroxidase1, 5 85.71(n)1
    89.5(a)1
      11 (52.25 cM)5
    138611  NM_007946.21  NP_031972.21 
     878640005 
    chicken
    (Gallus gallus)
    Aves MPO6
    Uncharacterized protein
    59(a)
    1 → many
    19(410358-421656)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    61(a)
    possible ortholog
    AAWZ02037755(870-14726)
    African clawed frog
    (Xenopus laevis)
    Amphibia PMR-12 polysomal ribonuclease 1 74.17(n)    U68724.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mpx1 myeloid-specific peroxidase 53.41(n)
    51.09(a)
      337514  NM_212779.1  NP_997944.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG102113 peroxidase 37(a)
    (best of 6)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea F32A5.2a3 Peroxidase 38(a)
    (best of 7)
      II(7245851-7249911)   --


    ENSEMBL Gene Tree for EPX (if available)
    TreeFam Gene Tree for EPX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EPX gene
    LPO2  TPO2  PXDNL2  PXDN2  MPO2  
    5 SIMAP similar genes for EPX using alignment to 1 protein entry:     PERE_HUMAN:
    MPO    LPO    TPO    PXDN    PXDNL

    EPX for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: PERE_HUMAN, P11678
    Polymorphism: Allelic variant in EPX is associated with Japanese cedar pollinosis which is a type I allergic
    disease with ocular and nasal symptoms that develop paroxysmally on contact with Japanese cedar pollen. These
    symptoms, which occur seasonally each year, are typical features of allergic rhinitis, such as sneezing,
    excessive nasal secretion, nasal congestion, and conjunctival itching


    10/478 SNPs in EPX are shown (see all 478)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1214345661,2,4
    CEosinophil peroxidase deficiency (EPD)4 pathogenic157289856(+) CTTCCG/ACTCGG 2 /H /R mis11Minor allele frequency- A:0.00NA 4552
    VAR_0601984
    ----see VAR_0601982 R L mis40--------
    rs353520021,2
    C,F--56273060(+) CACAC-/ACGTGCA 1 -- int15Minor allele frequency- AC:0.05NS 180
    rs339545891,2
    C,F--56273301(+) CCTTC-/CTTC  
            
    TTCCT
    1 -- int15Minor allele frequency- CTTC:0.33NS 146
    rs344152231,2
    C,F--56274781(+) CGTTG-/GAGTCC 1 -- int17Minor allele frequency- G:0.39NS CSA 180
    rs352097041,2
    C,F--56280870(+) AAGGCC/GCATAT 1 -- int16Minor allele frequency- G:0.05NS WA 288
    rs80774261,2
    C,F,A,H--56280957(+) CATGGG/ACAGAA 1 -- int123Minor allele frequency- A:0.22NS EA NA WA CSA 2510
    rs1123573711,2
    C,F--56280975(+) AATCTG/AGTTTC 1 -- int12Minor allele frequency- A:0.05CSA WA 120
    rs1127091721,2
    C--56281177(+) AGTCCC/TGGCTA 1 -- int11Minor allele frequency- T:0.50NA 2
    rs80787071,2
    C,F--56281249(+) GATCCT/CGCCAC 1 -- int14Minor allele frequency- C:0.25NA WA 8

    HapMap Linkage Disequilibrium report for EPX (56270089 - 56282535 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for EPX:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv457858CNV Loss19166990
    nsv517229CNV Gain+Loss19592680


    Human Gene Mutation Database (HGMD): EPX
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing EPX
    DNA2.0 Custom Variant and Variant Library Synthesis for EPX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 131399   
    OMIM disorders: 261500  
    UniProtKB/Swiss-Prot: PERE_HUMAN, P11678
  • Eosinophil peroxidase deficiency (EPD) [MIM:261500]: Autosomal recessive defect where anomalous
    eosinophils are characterized by nuclear hypersegmentation, hypogranulation, and negative peroxidase and
    phospholipid staining. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/52 diseases for EPX (see all 52):    About MalaCards
    eosinophil peroxidase deficiency    proctitis    urinary schistosomiasis    hodgkin's lymphoma, nodular sclerosis
    benign mesothelioma    chronic rhinitis    onchocerciasis    collagenous colitis
    endocarditis    pulmonary eosinophilia    eosinophilia    hypereosinophilic syndrome
    food allergy    allergic rhinitis    schistosomiasis    erythropoietic protoporphyria
    rhinitis    atopy    irritable bowel syndrome    aplastic anemia

    4 diseases from the University of Copenhagen DISEASES database for EPX:
    Asthma     Eosinophilia     Allergic rhinitis     Hypersensitivity reaction type I disease

    EPX for disorders           About GeneDecksing

    10/40 Novoseek inferred disease relationships for EPX gene (see all 40)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma 69.2 67 10520077 (5), 9556008 (4), 10212854 (3), 11106196 (3) (see all 26)
    eosinophilia 66.7 7 7534262 (2), 2217619 (1), 1847158 (1), 11169280 (1)
    asthma childhood 57.1 5 8221257 (1), 10383593 (1), 10336595 (1), 10445617 (1) (see all 5)
    inflammation 56.7 35 10520078 (2), 10520077 (2), 15257469 (2), 11106196 (2) (see all 27)
    hypereosinophilic syndrome 53.8 1 9785914 (1)
    asthma allergic 51.8 6 8648010 (2), 10090740 (1), 11106196 (1), 9510666 (1) (see all 5)
    allergy food 48.7 3 10520078 (2), 9052525 (1)
    allergy 47.8 6 8492464 (1), 11340681 (1), 18516076 (1), 11551254 (1) (see all 6)
    pulmonary eosinophilia 46.1 1 8818342 (1)
    allergic rhinitis 45.5 4 19439985 (2), 19133919 (1), 11520718 (1)

    Genetic Association Database (GAD): EPX
    Human Genome Epidemiology (HuGE) Navigator: EPX (2 documents)

    Export disorders for EPX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EPX gene, integrated from 9 sources (see all 286):
    (articles sorted by number of sources associating them with EPX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human eosinophil peroxidase. Evidence for the existence of a peroxidase multigene family. (PubMed id 2541222)1, 2, 3 Ten R.M....Gleich G.J. (1989)
    2. Molecular cloning and characterization of a chromosomal gene for human eosinophil peroxidase. (PubMed id 2550461)1, 2, 3 Sakamaki K.... Nagata S. (1989)
    3. Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase. (PubMed id 18694936)1, 2, 9 Ulrich M....Doering G. (2008)
    4. Human eosinophil peroxidase induces surface alteration, killing, and lysis of Mycobacterium tuberculosis. (PubMed id 12540536)1, 2, 9 Borelli V.... Zabucchi G. (2003)
    5. High contribution contrast between the genes of eosinophil peroxidase and IL-4 receptor alpha-chain in Japanese cedar pollinosis. (PubMed id 14657871)1, 2, 9 Nakamura H.... Eboshida A. (2003)
    6. Biochemical evidence for heme linkage through esters with Asp-93 and Glu-241 in human eosinophil peroxidase. The ester with Asp-93 is only partially formed in vivo. (PubMed id 10358043)1, 2, 9 Oxvig C.... Sottrup-Jensen L. (1999)
    7. Hereditary eosinophil peroxidase deficiency: immunochemical and spectroscopic studies and evidence for a compound heterozygosity of the defect. (PubMed id 7809065)1, 2, 9 Romano M.... Dri P. (1994)
    8. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    9. Analysis of the mechanism by which melatonin inhibits human eosinophil peroxidase. (PubMed id 18516076)7, 9 Lu T....Abu-Soud H.M. (2008)
    10. Association of single nucleotide polymorphisms in the eosinophil peroxidase gene with allergic rhinitis in the Czech population. (PubMed id 19439985)1, 9 Hrdlickova B. and Izakovicova-Holla L. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8288 HGNC: 3423 AceView: EPX Ensembl:ENSG00000121053 euGenes: HUgn8288
    ECgene: EPX Kegg: 8288 H-InvDB: EPX

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EPX Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/epx/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EPX gene:
    Search GeneIP for patents involving EPX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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