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Aliases for EPX Gene

Aliases for EPX Gene

  • Eosinophil Peroxidase 2 3 5
  • EC 4 63
  • EPO 3 4
  • EPP 3 4
  • EC 1.11.1 63
  • EPX-PEN 3
  • EPXD 3
  • EPER 4

External Ids for EPX Gene

Previous GeneCards Identifiers for EPX Gene

  • GC17P056014
  • GC17P058751
  • GC17P056612
  • GC17P056744
  • GC17P053625
  • GC17P056270
  • GC17P051630

Summaries for EPX Gene

Entrez Gene Summary for EPX Gene

  • This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded preproprotein is proteolytically processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a gene cluster with other peroxidase genes on chromosome 17. Mutations in this gene result in eosinophil peroxidase deficiency. [provided by RefSeq, Feb 2016]

GeneCards Summary for EPX Gene

EPX (Eosinophil Peroxidase) is a Protein Coding gene. Diseases associated with EPX include eosinophil peroxidase deficiency and proctitis. Among its related pathways are Cellular Senescence and HIF-1-alpha transcription factor network. GO annotations related to this gene include heme binding and peroxidase activity. An important paralog of this gene is PXDN.

UniProtKB/Swiss-Prot for EPX Gene

  • Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.

Gene Wiki entry for EPX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPX Gene

Genomics for EPX Gene

Regulatory Elements for EPX Gene

Promoters for EPX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EPX on UCSC Golden Path with GeneCards custom track

Genomic Location for EPX Gene

58,192,728 bp from pter
58,205,174 bp from pter
12,447 bases
Plus strand

Genomic View for EPX Gene

Genes around EPX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPX Gene

Proteins for EPX Gene

  • Protein details for EPX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Eosinophil peroxidase
    Protein Accession:
    Secondary Accessions:
    • Q4TVP3

    Protein attributes for EPX Gene

    715 amino acids
    Molecular mass:
    81040 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Name=heme b; Xref=ChEBI:CHEBI:60344;
    Quaternary structure:
    • Tetramer of two light chains and two heavy chains.

neXtProt entry for EPX Gene

Proteomics data for EPX Gene at MOPED

Selected DME Specific Peptides for EPX Gene

Post-translational modifications for EPX Gene

  • Glycosylation at Asn 52, Asn 113, Asn 327, Asn 363, Asn 700, and Asn 708
  • Modification sites at PhosphoSitePlus

Other Protein References for EPX Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for EPX Gene

Suggested Antigen Peptide Sequences for EPX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peroxidase family. XPO subfamily.
  • Belongs to the peroxidase family. XPO subfamily.
genes like me logo Genes that share domains with EPX: view

No data available for Gene Families for EPX Gene

Function for EPX Gene

Molecular function for EPX Gene

GENATLAS Biochemistry:
eosinophil peroxidase
UniProtKB/Swiss-Prot CatalyticActivity:
2 phenolic donor + H(2)O(2) = 2 phenoxyl radical of the donor + 2 H(2)O.
UniProtKB/Swiss-Prot Function:
Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.

Enzyme Numbers (IUBMB) for EPX Gene

Gene Ontology (GO) - Molecular Function for EPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity IEA --
genes like me logo Genes that share ontologies with EPX: view
genes like me logo Genes that share phenotypes with EPX: view

Animal Models for EPX Gene

MGI Knock Outs for EPX:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EPX Gene

Localization for EPX Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPX Gene

Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils.

Subcellular locations from

Jensen Localization Image for EPX Gene COMPARTMENTS Subcellular localization image for EPX gene
Compartment Confidence
extracellular 5
vacuole 3
chloroplast 2
endoplasmic reticulum 2
lysosome 2
plasma membrane 2
cytosol 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for EPX Gene

Pathways & Interactions for EPX Gene

genes like me logo Genes that share pathways with EPX: view

Gene Ontology (GO) - Biological Process for EPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002215 defense response to nematode IEA --
GO:0006979 response to oxidative stress IEA --
GO:0032693 negative regulation of interleukin-10 production IEA --
GO:0032714 negative regulation of interleukin-5 production IEA --
GO:0032753 positive regulation of interleukin-4 production IEA --
genes like me logo Genes that share ontologies with EPX: view

No data available for SIGNOR curated interactions for EPX Gene

Drugs & Compounds for EPX Gene

(30) Drugs for EPX Gene - From: Novoseek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Melatonin Approved Nutra Antagonist, Target, inhibitor Melatonin receptors MT inhibitor 234
L-Phenylalanine Approved Nutra 0
4-hydroxycoumarin Experimental Pharma 0
Formaldehyde Experimental Pharma 73
calcium Nutra 0

(44) Additional Compounds for EPX Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (alpha-)2-Phenylacetamide
  • 2-Phenyl-Acetamide
  • alpha-Phenylacetamide
  • alpha-Toluamide
  • alpha-Toluimidic acid
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
  • Alcool methylique
  • Alcool metilico
  • Carbinol
  • CH3OH
  • Colonial spirit
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with EPX: view

Transcripts for EPX Gene

mRNA/cDNA for EPX Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EPX Gene

Eosinophil peroxidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EPX Gene

No ASD Table

Relevant External Links for EPX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EPX Gene

mRNA expression in normal human tissues for EPX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EPX Gene

This gene is overexpressed in Whole Blood (x28.7).

Protein differential expression in normal tissues from HIPED for EPX Gene

This gene is overexpressed in Neutrophil (54.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EPX Gene

SOURCE GeneReport for Unigene cluster for EPX Gene Hs.279259

genes like me logo Genes that share expression patterns with EPX: view

Protein tissue co-expression partners for EPX Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for EPX Gene

Orthologs for EPX Gene

This gene was present in the common ancestor of animals.

Orthologs for EPX Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia EPX 35
  • 86.15 (n)
  • 85.5 (a)
(Mus musculus)
Mammalia Epx 35
  • 85.71 (n)
  • 89.5 (a)
Epx 16
Epx 36
  • 89 (a)
(Pan troglodytes)
Mammalia EPX 35
  • 99.44 (n)
  • 99.58 (a)
EPX 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Epx 35
  • 85.01 (n)
  • 88.66 (a)
(Monodelphis domestica)
Mammalia EPX 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia EPX 36
  • 79 (a)
(Gallus gallus)
Aves -- 36
  • 59 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12335 35
African clawed frog
(Xenopus laevis)
Amphibia PMR-1 35
(Danio rerio)
Actinopterygii mpx 35
  • 53.6 (n)
  • 51.09 (a)
CU184832.2 36
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10211 37
  • 37 (a)
CG5873 37
  • 34 (a)
CG6879 37
  • 35 (a)
CG6969 37
  • 34 (a)
CG8913 37
  • 25 (a)
pxt 37
  • 29 (a)
Pxt 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea C46A5.4 37
  • 34 (a)
F09F3.5 37
  • 31 (a)
F32A5.2a 37
  • 38 (a)
F32A5.2b 37
  • 38 (a)
K10B4.1 37
  • 33 (a)
R08F11.7 37
  • 30 (a)
ZK430.8 37
  • 35 (a)
K10B4.1 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for EPX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EPX Gene

Gene Tree for EPX (if available)
Gene Tree for EPX (if available)

Paralogs for EPX Gene

Paralogs for EPX Gene

(5) SIMAP similar genes for EPX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EPX: view

Variants for EPX Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for EPX Gene

Allelic variant in EPX is associated with Japanese cedar pollinosis which is a type I allergic disease with ocular and nasal symptoms that develop paroxysmally on contact with Japanese cedar pollen. These symptoms, which occur seasonally each year, are typical features of allergic rhinitis, such as sneezing, excessive nasal secretion, nasal congestion, and conjunctival itching.

Sequence variations from dbSNP and Humsavar for EPX Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs121434566 Eosinophil peroxidase deficiency (EPXD) 58,196,994(+) CTTCC(A/G)CTCGG reference, missense
rs2302311 - 58,203,086(+) GGTAC(A/T)ATGCT reference, missense
rs11079339 - 58,193,081(+) TGCAT(A/G)GCAGA reference, missense
rs11652709 - 58,193,733(+) CCACA(C/G)CTGCG reference, missense
rs35896669 - 58,195,115(+) CACTG(A/C)AGGCG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for EPX Gene

Variant ID Type Subtype PubMed ID
nsv517229 CNV Gain+Loss 19592680
nsv457858 CNV Loss 19166990

Variation tolerance for EPX Gene

Residual Variation Intolerance Score: 97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.42; 92.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EPX Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for EPX Gene

MalaCards: The human disease database

(23) MalaCards diseases for EPX Gene - From: Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
eosinophil peroxidase deficiency
  • eosinophil peroxidase deficiency, partial
  • proctitis nos
  • runny nose
conjunctival nevus
  • nevus of conjunctiva
- elite association - COSMIC cancer census association via MalaCards
Search EPX in MalaCards View complete list of genes associated with diseases


  • Eosinophil peroxidase deficiency (EPXD) [MIM:261500]: A rare abnormality without clinical symptoms characterized by decreased or absent peroxidase activity and decreased volume of the granule matrix in eosinophils. {ECO:0000269 PubMed:7809065}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for EPX

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with EPX: view

No data available for Genatlas for EPX Gene

Publications for EPX Gene

  1. Molecular cloning of the human eosinophil peroxidase. Evidence for the existence of a peroxidase multigene family. (PMID: 2541222) Ten R.M. … Gleich G.J. (J. Exp. Med. 1989) 2 3 4 67
  2. Analysis of the mechanism by which melatonin inhibits human eosinophil peroxidase. (PMID: 18516076) Lu T. … Abu-Soud H.M. (Br. J. Pharmacol. 2008) 23 25 26
  3. Association of single nucleotide polymorphisms in the eosinophil peroxidase gene with allergic rhinitis in the Czech population. (PMID: 19439985) Hrdlickova B. … Izakovicova-Holla L. (Int. Arch. Allergy Immunol. 2009) 3 23
  4. Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase. (PMID: 18694936) Ulrich M. … Doering G. (J. Biol. Chem. 2008) 3 23
  5. Thiocyanate modulates the catalytic activity of mammalian peroxidases. (PMID: 15894800) Tahboub Y.R. … Abu-Soud H.M. (J. Biol. Chem. 2005) 3 23

Products for EPX Gene

Sources for EPX Gene

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