EPX Gene
protein-coding GIFtS: 60
GCID: GC17P056270
|
|
eosinophil peroxidase
| |
Aliases
for EPX gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Eosinophil Peroxidase1 2 | | EC 1.11.1.73 8 | | EPO1 2 3 | | EPER3 | | EPP1 2 3 | | EC 1.11.18 | | EPX-PEN1 2 | | |
Export aliases for EPX gene to outside databasesPrevious GC identifers: GC17P056014 GC17P058751 GC17P056612 GC17P056744 GC17P053625 GC17P051630 |
Summaries
for EPX gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for EPX:
This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded precursor protein isprocessed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant.The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa orparasitic worms. The gene is found in a cluster of three peroxidase genes at chromosome 17q23. Mutations in this generesult in eosinophil peroxidase deficiency. (provided by RefSeq, Sep 2009)
UniProtKB/Swiss-Prot: PERE_HUMAN, P11678Function: Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significantinhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis
Gene Wiki entry for EPX (Eosinophil peroxidase)
|
Genomic Views
for EPX gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EPX gene promoter:
NF-1/L E2F-1 E2F NRSF form 1 HNF-4alpha2 Nkx2-5 NRSF form 2 HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for EPX
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPX |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q23.1 Ensembl cytogenetic band: 17q22 HGNC cytogenetic band: 17q23.1EPX Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P056270: view genomic region
(about GC identifiers)
Start:
|
56,270,089 bp from pter |
End:
|
56,282,535 bp from pter |
Size:
|
12,447 bases |
Orientation:
|
plus strand |
|
Proteins
for EPX gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PERE_HUMAN, P11678 (See
protein sequence)Recommended Name: Eosinophil peroxidase precursor Size: 715 amino acids; 81040 Da
Cofactor: Binds 1 calcium ion per heterodimer (By similarity)
Cofactor: Binds 1 heme B (iron-protoporphyrin IX) covalently through ester linkages to hydroxylated methyl groupsformed auto-catalytically with hydrogen peroxide at the heme C-1 and C-5 positions. The ester linkage to Asp-232 wasobserved in 30% of the chains
Subunit: Tetramer of two light chains and two heavy chains
Subcellular location: Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils
Secondary accessions: Q4TVP3Explore the universe of human proteins at neXtProt for EPX: NX_P11678
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P11678
4/6 DME Specific Peptides for EPX (P11678) (see all 6)
EPX Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000493.1
ENSEMBL proteins: ENSP00000225371
Human Recombinant Protein Products:
EPX Antibody Products:
Assay Products for EPX: |
Protein
Domains /
Families
for EPX gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EPX for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P11678ProtoNet protein and cluster: P11678 2 Blocks protein families: IPB002007 Animal haem peroxidase signature IPB010255 Haem peroxidase
UniProtKB/Swiss-Prot: PERE_HUMAN, P11678Similarity: Belongs to the peroxidase family. XPO subfamily |
Function
for EPX gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PERE_HUMAN, P11678Function: Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significantinhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysisCatalytic activity: 2 phenolic donor + H(2)O(2) = 2 phenoxyl radical of the donor + 2 H(2)O Genatlas biochemistry entry for EPX:eosinophil peroxidase
Enzyme Numbers (IUBMB): EC 1.11.1.71 2 EC 1.11.12
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EPX (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EPX
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: EPX (NM_000502) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EPX | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPX |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPX |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
EPX for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Epxtm1Nal for EPX
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Epx):
EPX for phenotypes About GeneDecksing
|
Pathways & Interactions
for EPX gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Allograft rejection | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for EPX):
EPX for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EPX
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for EPX (P116783 ENSP000002253714) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002215 | defense response to nematode |
IEA | -- | | GO:0032693 | negative regulation of interleukin-10 production |
IEA | -- | | GO:0032714 | negative regulation of interleukin-5 production |
IEA | -- | | GO:0032753 | positive regulation of interleukin-4 production |
IEA | -- | | GO:0042744 | hydrogen peroxide catabolic process |
IEA | -- |
EPX for ontologies About GeneDecksing
|
Drugs & Compounds
for EPX gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
EPX for compounds About GeneDecksing
 Browse Tocris compounds for EPX
10/11 HMDB Compounds for EPX (see all 11) About this table
1 DrugBank Compound for EPX About this table
10/64 Novoseek chemical compound relationships for EPX gene (see all 64) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hobr |
88.2 |
23 |
2002037 (4), 1985118 (3), 16166591 (1), 8860070 (1) (see all 10) |
| lte4 |
72.7 |
24 |
11106196 (5), 11551254 (3), 9761018 (2), 9824404 (2) (see all 8) |
| fml |
72.5 |
6 |
8301549 (3), 7752089 (1) |
| hocl |
66 |
9 |
16166591 (1), 1985118 (1), 19708016 (1), 10464338 (1) (see all 5) |
| bromide |
65.1 |
27 |
8860070 (2), 2154520 (2), 18516076 (2), 8825615 (1) (see all 11) |
| ltc4 |
62.6 |
16 |
8387540 (4), 7887808 (3), 8301549 (3), 1334102 (2) (see all 7) |
| cytochalasin b |
62.4 |
36 |
8301549 (4), 8049081 (3), 7752089 (2), 8498524 (2) (see all 12) |
| fmlp |
62.1 |
30 |
9425641 (3), 8049081 (3), 9482706 (3), 17206716 (2) (see all 14) |
| thiocyanate |
62 |
8 |
2154520 (2), 8825615 (1), 15894800 (1), 11112545 (1) (see all 5) |
| histamine |
55.9 |
34 |
10380774 (4), 9186539 (3), 7514197 (3), 11015298 (3) (see all 18) |
Search CenterWatch for drugs/clinical trials and news about EPX / PERE
|
Transcripts
for EPX gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EPX gene: NM_000502.4 Unigene Cluster for EPX: Eosinophil peroxidase Hs.279259 [show with all ESTs]Unigene Representative Sequence: NM_0005021 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000225371(uc002ivq.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EPX (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EPX
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: EPX (NM_000502) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EPX | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPX |
Additional cDNA sequence: X14346.1 2 DOTS entries: DT.106307 DT.100742357 16 AceView cDNA sequences: BX953021 BX280635 BF901945 AL597635 NM_000502 AW950277 BX644277 X14346 T28019 AJ705406 W92864 AJ706023 AJ706564 AW468162 W92863 AW027066
GeneLoc Exon Structure
|
Expression
for EPX gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EPX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTGCTTCT
About this image
See EPX Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EPX
SOURCE GeneReport for Unigene cluster: Hs.279259
SABiosciences Expression via Pathway-Focused PCR Arrays including EPX:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EPX
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EPX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPX | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPX |
Orthologs
for EPX gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for EPX gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MPO6 |
Uncharacterized protein |
61(a) |
1 → many |
19(414171-424206) |
lizard
(Anolis carolinensis) |
Reptilia |
--LPO6 |
-- |
61(a)48(a) |
1 ↔ manypossible ortholog |
AAWZ02037755(870-14726) GL344475.1(242-2089) |
African clawed frog
(Xenopus laevis) |
Amphibia |
PMR-12 |
polysomal ribonuclease 1 |
74.17(n) |
|
U68724.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
mpx1 |
myeloid-specific peroxidase |
53.41(n)
51.09(a) |
|
337514 NM_212779.1 NP_997944.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
F32A5.2a3 |
Peroxidase |
38(a)
(best of 7) |
|
II(7245851-7249911) -- |
ENSEMBL Gene Tree for EPX (if available)
TreeFam Gene Tree for EPX (if available) |
Paralogs
for EPX gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for EPX gene
- LPO2 TPO2 PXDNL2 PXDN2 MPO2
5 SIMAP similar genes for EPX using alignment to 1 protein entry: PERE_HUMAN:MPO LPO TPO PXDN PXDNL
EPX for paralogs About GeneDecksing
|
Genomic Variants
for EPX gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: PERE_HUMAN, P11678Polymorphism: Allelic variant in EPX is associated with Japanese cedar pollinosis which is a type I allergic diseasewith ocular and nasal symptoms that develop paroxysmally on contact with Japanese cedar pollen. These symptoms, whichoccur seasonally each year, are typical features of allergic rhinitis, such as sneezing, excessive nasal secretion,nasal congestion, and conjunctival itching
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EPX (56270089 - 56282535 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for EPX: --
Human Gene Mutation Database (HGMD): EPX
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EPX |
|
Disorders
/ Diseases
for EPX gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EPX for disorders About GeneDecksing
OMIM gene information: 131399
OMIM disorders: 261500
UniProtKB/Swiss-Prot: PERE_HUMAN, P11678
Defects in EPX are the cause of eosinophil peroxidase deficiency (EPD) [MIM:261500]. EPD is an autosomalrecessive defect where anomalous eosinophils are characterized by nuclear hypersegmentation, hypogranulation, andnegative peroxidase and phospholipid staining
20/59  diseases for EPX (see all 59): About MalaCardseosinophil peroxidase deficiency erythropoietic protoporphyria hodgkin's lymphoma, nodular sclerosis malignant pleural mesothelioma
allergic rhinitis food allergy hypereosinophilic syndrome inflammatory bowel disease
pulmonary eosinophilia proctitis rhinitis urinary schistosomiasis
onchocerciasis irritable bowel syndrome chronic obstructive pulmonary disease eosinophilia
collagenous colitis bronchopulmonary dysplasia benign mesothelioma aplastic anemia
4 diseases from the University of Copenhagen DISEASES database for EPX:Asthma Eosinophilia Hypersensitivity reaction type I disease Allergic rhinitis 10/40 Novoseek disease relationships for EPX gene (see all 40) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| asthma |
69.2 |
67 |
10520077 (5), 9556008 (4), 10212854 (3), 11106196 (3) (see all 26) |
| eosinophilia |
66.7 |
7 |
7534262 (2), 2217619 (1), 1847158 (1), 11169280 (1) |
| asthma childhood |
57.1 |
5 |
8221257 (1), 10383593 (1), 10336595 (1), 10445617 (1) (see all 5) |
| inflammation |
56.7 |
35 |
10520078 (2), 10520077 (2), 15257469 (2), 11106196 (2) (see all 27) |
| hypereosinophilic syndrome |
53.8 |
1 |
9785914 (1) |
| asthma allergic |
51.8 |
6 |
8648010 (2), 10090740 (1), 11106196 (1), 9510666 (1) (see all 5) |
| allergy food |
48.7 |
3 |
10520078 (2), 9052525 (1) |
| allergy |
47.8 |
6 |
8492464 (1), 11340681 (1), 18516076 (1), 11551254 (1) (see all 6) |
| pulmonary eosinophilia |
46.1 |
1 |
8818342 (1) |
| allergic rhinitis |
45.5 |
4 |
19439985 (2), 19133919 (1), 11520718 (1) |
Human Genome Epidemiology (HuGE) Navigator: EPX (2 documents)
Export disorders for EPX gene to outside databases
|
Publications
for EPX gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EPX gene, integrated from 9 sources (see all 286):
(articles sorted by number of sources associating them with EPX) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of the human eosinophil peroxidase. Evidence for the existence of a peroxidase multigene family. (PubMed id 2541222)1, 2, 3 Ten R.M....Gleich G.J. (1989)
- Molecular cloning and characterization of a chromosomal gene for human eosinophil peroxidase. (PubMed id 2550461)1, 2, 3 Sakamaki K.... Nagata S. (1989)
- Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase. (PubMed id 18694936)1, 2, 9 Ulrich M....Doering G. (2008)
- Human eosinophil peroxidase induces surface alteration, killing, and lysis of Mycobacterium tuberculosis. (PubMed id 12540536)1, 2, 9 Borelli V.... Zabucchi G. (2003)
- High contribution contrast between the genes of eosinophil peroxidase and IL-4 receptor alpha-chain in Japanese cedar pollinosis. (PubMed id 14657871)1, 2, 9 Nakamura H.... Eboshida A. (2003)
- Biochemical evidence for heme linkage through esters with Asp-93 and Glu-241 in human eosinophil peroxidase. The ester with Asp-93 is only partially formed in vivo. (PubMed id 10358043)1, 2, 9 Oxvig C.... Sottrup-Jensen L. (1999)
- Hereditary eosinophil peroxidase deficiency: immunochemical and spectroscopic studies and evidence for a compound heterozygosity of the defect. (PubMed id 7809065)1, 2, 9 Romano M.... Dri P. (1994)
- Analysis of the mechanism by which melatonin inhibits human eosinophil peroxidase. (PubMed id 18516076)7, 9 Lu T....Abu-Soud H.M. (2008)
- Association of single nucleotide polymorphisms in the eosinophil peroxidase gene with allergic rhinitis in the Czech population. (PubMed id 19439985)1, 9 Hrdlickova B. and Izakovicova-Holla L. (2009)
- Association of single nucleotide polymorphisms in the eosinophil peroxidase gene with Japanese cedar pollinosis. (PubMed id 15316147)1, 9 Nakamura H....Eboshida A. (2004)
|
External Searches for EPX gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing EPX gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing EPX gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EPX gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for EPX | Pharmacogenomics, SNPs, Pathways | | NIEHS-SNPs | http://egp.gs.washington.edu/data/epx/ |
|
| | |
About This Section
| Patent Information for EPX gene:
Search GeneIP for patents involving EPX
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for EPX gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for EPX | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EPX | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EPX | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for EPX | | OriGene 3'-UTR Clone for EPX | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EPX | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EPX | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for EPX | | OriGene Custom Protein Services for EPX | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EPX | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EPX | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPX | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPX |
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| | | | Search Tocris compounds for EPX |
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 | | | EPX Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPX |
|  |  |  | | | | Search ThermoFisher Antibodies for EPX |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPX |
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