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EPS15L1 Gene

protein-coding   GIFtS: 51
GCID: GC19M016466

Epidermal Growth Factor Receptor Pathway Substrate 15-Like...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Epidermal Growth Factor Receptor Pathway Substrate 15-Like 11 2
Eps15-Related Protein2 3
EPS15R2 3
Epidermal Growth Factor Receptor Substrate 15-Like 12
Epidermal Growth Factor Receptor Substrate EPS15R2
Eps15R3

External Ids:    HGNC: 246341   Entrez Gene: 585132   Ensembl: ENSG000001275277   UniProtKB: Q9UBC23   

Export aliases for EPS15L1 gene to outside databases

Previous GC identifers: GC19M016333 GC19M016041


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for EPS15L1 Gene:
EPS15L1 (epidermal growth factor receptor pathway substrate 15-like 1) is a protein-coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is REPS1.

UniProtKB/Swiss-Prot: EP15R_HUMAN, Q9UBC2
Function: Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated
endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization
of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2

Gene Wiki entry for EPS15L1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the EPS15L1 gene promoter:
         SRF   AhR   SRF (504 AA)   HSF1 (long)   CUTL1   E47   Hand1   HSF1short   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEPS15L1 promoter sequence
   Search Chromatin IP Primers for EPS15L1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EPS15L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.12

EPS15L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPS15L1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M016466:  view genomic region     (about GC identifiers)

Start:
16,466,050 bp from pter      End:
16,582,896 bp from pter
Size:
116,847 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: EP15R_HUMAN, Q9UBC2 (See protein sequence)
Recommended Name: Epidermal growth factor receptor substrate 15-like 1  
Size: 864 amino acids; 94255 Da
Subunit: Interacts with EPS15, AGFG1/HRB and AGFG2/HRBL. Associates with the clathrin-associated adapter protein
complex 2 (AP-2) (By similarity). Interacts with FCHO1. Interacts with FCHO2. Interacts (via EH domains) with
DAB2
Caution: Studies in clathrin-mediated endocytosis used a siRNA mixture of EPS15 and EPS15L1 (PubMed:22648170)
Secondary accessions: A2RRF3 A5PL29 B4DKA3
Alternative splicing: 4 isoforms:  Q9UBC2-1   Q9UBC2-2   Q9UBC2-3   Q9UBC2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EPS15L1: NX_Q9UBC2

Explore proteomics data for EPS15L1 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues by EGFR (By similarity)1
  • Ubiquitination2 at Lys531, Lys534, Lys604, Lys632, Lys638, Lys683, Lys694, Lys701, Lys829, Lys838
  • Modification sites at PhosphoSitePlus

  • See EPS15L1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001245303.1  NP_001245304.1  NP_001245305.1  NP_067058.1  

    ENSEMBL proteins: 
     ENSP00000469495   ENSP00000471981   ENSP00000393313   ENSP00000465286   ENSP00000248070  
     ENSP00000440103   ENSP00000471662   ENSP00000473242   ENSP00000472771   ENSP00000472267  
     ENSP00000472958   ENSP00000472135   ENSP00000468866  
    Reactome Protein details: Q9UBC2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    4 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR000261 EPS15_homology
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q9UBC2

    ProtoNet protein and cluster: Q9UBC2

    1 Blocks protein domain: IPB000261 EPS15 homology (EH)

    UniProtKB/Swiss-Prot: EP15R_HUMAN, Q9UBC2
    Similarity: Contains 1 EF-hand domain
    Similarity: Contains 3 EH domains


    Find genes that share domains with EPS15L1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EP15R_HUMAN, Q9UBC2
    Function: Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated
    endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization
    of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI19262564
         
    Find genes that share ontologies with EPS15L1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for EPS15L1

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    1 qRT-PCR Assays for microRNA that regulate EPS15L1:
    hsa-miR-2276
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EP15R_HUMAN, Q9UBC2: Cell membrane; Peripheral membrane protein (By similarity). Nucleus (By similarity).
    Membrane, coated pit (By similarity). Note=Localized to plasma membrane coated pits (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus3
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane TAS--
    GO:0005905coated pit IEA--

    Find genes that share ontologies with EPS15L1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EPS15L1 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR
    Signaling by EGFR0.83
    Signaling by EGFR in Cancer0.82
    2Signaling by GPCR
    Signal Transduction0.58
    3EGFR downregulation
    EGFR downregulation
    4EGFR1 Signaling Pathway
    EGFR1 Signaling Pathway
    5Disease
    Disease


    Find genes that share SuperPaths with EPS15L1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for EPS15L1
        EGFR1 Signaling Pathway

    1 Reactome Pathway for EPS15L1
        EGFR downregulation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EPS15L1
    Interactions:

        GeneGlobe Interaction Network for EPS15L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EPS15L1 (Q9UBC21, 2, 3 ENSP000002480704) via UniProtKB, MINT, STRING, and/or I2D (see all 217)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0042059negative regulation of epidermal growth factor receptor signaling pathway TAS--

    Find genes that share ontologies with EPS15L1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EPS15L1 (EP15R)

    1 Novoseek inferred chemical compound relationship for EPS15L1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 31.1 4 9446614 (3), 7797522 (1)



    Find genes that share compounds with EPS15L1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EPS15L1 gene (4 alternative transcripts): 
    NM_001258374.1  NM_001258375.1  NM_001258376.1  NM_021235.2  

    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000594851 ENST00000602022 ENST00000455140(uc002ndx.3 uc002ndy.3)
    ENST00000592031 ENST00000248070(uc010xpe.1 uc002ndz.1 uc010xpf.1 uc002nea.1 uc010eah.1 uc002nec.1)
    ENST00000535753(uc002neb.1) ENST00000594975 ENST00000599790 ENST00000602009
    ENST00000597937 ENST00000596151 ENST00000593760 ENST00000596037 ENST00000597559
    ENST00000602151 ENST00000595845
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate EPS15L1:
    hsa-miR-2276
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    Inhib. RNA
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    Selected AceView cDNA sequences (see all 189):

    BM452807 CA446537 BX471508 BI754269 BX102709 AL520086 BM920961 T05110 
    BM466296 AB015346 BQ883878 BM917198 BG203298 BE795352 AV710549 AA886803 
    AL110270 NM_021235 BU541120 BM970257 BE791563 BC037558 BQ711645 BU174868 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for EPS15L1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
    SP1:                                            -                                                                 -                                             
    SP2:                                            -                                                                 -                                   -         
    SP3:                                            -                                                                                                               
    SP4:                                                                                                                                                            


    ECgene alternative splicing isoforms for EPS15L1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EPS15L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGCCGCCT
    EPS15L1 Expression
    About this image

    EPS15L1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EPS15L1 Protein Expression
        Custom PCR Arrays for EPS15L1
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for EPS15L1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Eps15l11 , 5 epidermal growth factor receptor pathway substrate more1, 5 86.99(n)1
    92.83(a)1
      8 (35.02 cM)5
    138591  NM_007944.31  NP_031970.21 
     723410015 
    chicken
    (Gallus gallus)
    Aves EPS15L11 epidermal growth factor receptor pathway substrate more 78.29(n)
    85.05(a)
      420147  XM_004948937.1  XP_004948994.1 
    lizard
    (Anolis carolinensis)
    Reptilia EPS15L16
    epidermal growth factor receptor pathway substrate...
    55(a)
    1 ↔ 1
    AAWZ02037942(4219-13551)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia eps15l11 epidermal growth factor receptor pathway substrate more 70.78(n)
    77.55(a)
      100158630  NM_001128041.1  NP_001121513.1 
    zebrafish
    (Danio rerio)
    Actinopterygii eps15l1a1 epidermal growth factor receptor pathway substrate more 70.54(n)
    74.38(a)
      568170  XM_691483.5  XP_696575.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta Eps-151 Epidermal growth factor receptor pathway substrate more 50.85(n)
    44.58(a)
      37961  NM_001259573.1  NP_001246502.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ehs-11 ehs-1 41.14(n)
    34.51(a)
      173985  NM_001027328.4  NP_001022499.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes EDE16
    Key endocytic protein involved in a network of int...
    14(a)
    1 → many
    II(127895-132040) YBL047C


    ENSEMBL Gene Tree for EPS15L1 (if available)
    TreeFam Gene Tree for EPS15L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EPS15L1 gene
    REPS12  EHD32  REPS22  EHD22  EHD12  EHD42  ITSN12  EPS152  
    ITSN22  SRL2  
    4 SIMAP similar genes for EPS15L1 using alignment to 10 protein entries:     EP15R_HUMAN (see all proteins):
    DKFZp586A0524    EPS15    ITSN1    REPS1

    Find genes that share paralogs with EPS15L1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EPS15L1 (see all 2332)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs124601831,2
    C,H--16151793(+) GGGGCC/TGTAGA 6 -- int10--------
    rs28857061,2
    C,A--16151854(+) GCCGCA/CCACAC 6 -- ut51 nc-transcript-variant7Minor allele frequency- C:0.40NA WA EA 366
    rs1178663841,2
    C,F--16151859(+) CCACAC/AGCAGC 6 -- ut51 nc-transcript-variant1Minor allele frequency- A:0.03NA 120
    rs1460604871,2
    --16153799(+) ATTGCA/GAAAGT 6 -- int10--------
    rs1900709371,2
    --16465950(+) TTTTTA/TAAAGT 2 -- int10--------
    rs1827224551,2
    C--16466034(+) GTTTAC/TAGAGA 2 -- int10--------
    rs1866764691,2
    --16466038(+) ACAGAG/TATTAA 2 -- int10--------
    rs1118707771,2
    C--16466045(+) TTAAAG/TAAGCT 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs104035551,2
    C--16466159(+) GCGGGC/TGGGGA 2 -- ut31 nc-transcript-variant8Minor allele frequency- T:0.00NA WA CSA 133
    rs557129491,2
    C,F--16466444(+) TGTGTA/GTATAT 2 -- ut31 nc-transcript-variant1Minor allele frequency- G:0.07NA 120

    HapMap Linkage Disequilibrium report for EPS15L1 (16466050 - 16582896 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for EPS15L1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667853CNV Deletion23128226
    nsv911166CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EPS15L1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease from the University of Copenhagen DISEASES database for EPS15L1:
    Tetralogy of Fallot

    Find genes that share disorders with EPS15L1           About GenesLikeMe

    Genetic Association Database (GAD): EPS15L1

    Export disorders for EPS15L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EPS15L1 gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with EPS15L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. (PubMed id 22190364)1, 4 Patsopoulos N.A....de Bakker P.I. (Ann. Neurol. 2011)
    2. FCHo proteins are nucleators of clathrin-mediated endocytosis. (PubMed id 20448150)1, 2 Henne W.M.... McMahon H.T. (Science 2010)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    4. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Selection system for genes encoding nuclear-targeted proteins. (PubMed id 9853615)1, 2 Ueki N.... Muramatsu M.-A. (Nat. Biotechnol. 1998)
    7. eps15 and eps15R are essential components of the endocytic pathway. (PubMed id 9407958)1, 2 Carbone R.... Di Fiore P.P. (Cancer Res. 1997)
    8. Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization. (PubMed id 9446614)1, 9 Coda L....Di Fiore P.P. (J. Biol. Chem. 1998)
    9. A ubiquitin-interacting motif (UIM) is essential for Eps15 and Eps15R ubiquitination. (PubMed id 12072436)1, 9 Klapisz E....van Bergen en Henegouwen P.M. (J. Biol. Chem. 2002)
    10. Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery. (PubMed id 11381094)1, 9 Martina J.A.... Bonifacino J.S. (J. Cell Biol. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 58513 HGNC: 24634 AceView: EPS15L1 Ensembl:ENSG00000127527 euGenes: HUgn58513
    ECgene: EPS15L1 H-InvDB: EPS15L1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EPS15L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EPS15L1 gene:
    Search GeneIP for patents involving EPS15L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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