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EPS15 Gene

protein-coding GIFtS: 62

GC01M051532

epidermal growth factor receptor pathway substrate 15
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AF-1P ^¹, ²
AF1P ^², ³
MLLT5 ^¹, ²
OTTHUMP00000009896 ^²

Descriptions
ALL1 fused gene from chromosome 1 ^²
Protein AF-1p ^³
Protein Eps15 ^³
epidermal growth factor receptor pathway substrate 15 ^²

External Ids
HGNC: 3419¹
Entrez Gene: 2060²
UniProtKB: P42566³
Ensembl: ENSG00000085832⁷

Search outside databases for aliases for EPS15 gene

Previous GC identifers: GC01M051447 GC01M050709 GC01M051179 GC01M051190

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for EPS15:

This gene encodes a protein that is part of the EGFR pathway. The protein is present at

clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene

is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing

results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq]

UniProtKB/Swiss-Prot: EPS15_HUMAN, P42566

Function: Involved in cell growth regulation. May be involved in the regulation of mitogenic

signals and control of cell proliferation. Involved in the internalization of ligand-inducible

receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the

assembly of clathrin-coated pits (By similarity)

Gene Wiki entry for EPS15

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the EPS15 gene

Entrez Gene cytogenetic band: 1p32 Ensembl cytogenetic band: 1p32.3 HGNC cytogenetic band: 1p32

EPS15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M051532: (about GC identifiers)

Start:	51,592,523 bp from pter
End:	51,757,583 bp from pter
Size:	165,061 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: EPS15_HUMAN, P42566 (See protein sequence)

Recommended Name: Epidermal growth factor receptor substrate 15

Size: 896 amino acids; 98656 Da

Subunit: Interacts with HGS; the interaction bridges the interaction of STAM or STAM2 with EPS15.

Isoform 2 interacts with HGS and AP2A2. Part of a complex at least composed of EPS15, HGS, and

either STAM1 or STAM2. Binds AP2A2 and AP2B1. Binds STON2 and EPN1. Interacts (via its SH3-binding

sites) with CRK. Interacts with SH3BP4/TTP

Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Note=Recruited to the plasma membrane upon EGFR activation and localizes to coated pits

Subcellular location: Isoform 2: Early endosome membrane; Peripheral membrane protein; Cytoplasmic

side. Note=Colocalizes with HGS on bilayered clathrin coats on endosomes

PDB structures from and Proteopedia :

1C07 (3D)

1EH2 (3D)

1F8H (3D)

1FF1 (3D)

2IV9 (3D)

2JXC (3D)

Secondary accessions: B2R8J7 Q5SRH4

Alternative splicing: 2 isoforms: P42566-1 P42566-2

Post-translational modifications:

Phosphorylation on Tyr-849 is involved in the internalization of EGFR. Not required for membrane

translocation after EGF treatment or for targeting to coated pits, but essential for a subsequent

step in EGFR endocytosis (By similarity). Phosphorylated on serine upon DNA damage, probably by

ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001153441.1 NP_001972.1

ENSEMBL proteins:

ENSP00000360798 ENSP00000379424 ENSP00000360792 ENSP00000360795 ENSP00000379428

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (EPS15)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005768	endosome	IEA	--
GO:0005829	cytosol	EXP	10567358 12218189 15962011
GO:0005886	plasma membrane	IDA	15465819
GO:0005905	coated pit	TAS	9762922

About this table

Antibodies for EPS15:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for EPS15
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (EPS15), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (EPS15)
	Novus Biologicals Antibodies for EPS15

Assays for EPS15:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P42566

ProtoNet protein and cluster: P42566

2 Blocks protein families:

IPB000261 EPS15 homology (EH)

IPB003903 Ubiquitin interacting motif

UniProtKB/Swiss-Prot: EPS15_HUMAN, P42566

Domain: The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins

Similarity: Contains 2 EF-hand domains

Similarity: Contains 3 EH domains

Similarity: Contains 2 UIM (ubiquitin-interacting motif) repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EPS15)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EPS15)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001981

Applied Biosystems Silencer® siRNAs for EPS15

Sigma-Aldrich siRNA and siRNA Panels for EPS15

Sigma-Aldrich shRNA for EPS15

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001981
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001981
untagged cDNA clone in CMV expression vector: NM_001981

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001981

UniProtKB/Swiss-Prot: EPS15_HUMAN, P42566

Function: Involved in cell growth regulation. May be involved in the regulation of mitogenic

signals and control of cell proliferation. Involved in the internalization of ligand-inducible

receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the

assembly of clathrin-coated pits (By similarity)

Genatlas biochemistry entry for EPS15:

EGFR pathway substrate,mouse eps15 homolog,likely involved in cell growth regulation

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	10613896 17474147
GO:0017124	SH3 domain binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for EPS15 (Your Favorite Gene powered by Ingenuity)

Clathrin-mediated Endocytosis

GeneDecks EPS15 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for EPS15

5/73 Interacting proteins for EPS15 (P42566^{1, 2} ENSP00000360798³) via UniProtKB, MINT, and/or STRING (see all 73 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STON2	Q8WXE9², ENSP00000267540³	MINT-6180038 MINT-6180111 MINT-6180129 MINT-6180018 MINT-6179779 MINT-6179905 MINT-6180093 MINT-6179941 MINT-6180075 MINT-6179996 MINT-6179890 MINT-6179923 MINT-6179875 MINT-6179857 MINT-6179977 MINT-6180056 STRING (score=.999)
UBQLN1	Q9UMX0², ENSP00000365576³	MINT-4300195 MINT-4300120 MINT-4302859 MINT-4302787 MINT-4302826 STRING (score=.773)
NUMB	P49757², ENSP00000347169³	MINT-17946 MINT-17947 STRING (score=.996)
EPN1	Q9Y6I3², ENSP00000270460³	MINT-6179958 STRING (score=.999)
GRB2	P62993¹, ENSP00000339007³	EBI-396684, EBI-401755 STRING (score=.994)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007173	epidermal growth factor receptor signaling pathway	TAS	8183552
GO:0008283	cell proliferation	TAS	8183552
GO:0015031	protein transport	IEA	--
GO:0016050	vesicle organization	TAS	9762922

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for EPS15
5 Novoseek chemical compound relationships for EPS15 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	44.63	27	10953014 (5), 19109251 (3), 7689153 (2), 9162018 (2) (see all 14)
phosphotyrosine	39.52	6	15465819 (1), 10953014 (1), 15155807 (1)
cholesterol	0.00	2	16919152 (1), 17919781 (1)
lipid	0.00	1	16887992 (1)
phosphatidylinositol	0.00	2	17412695 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EPS15)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EPS15)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001981

Sigma-Aldrich siRNA and siRNA Panels for EPS15

Sigma-Aldrich shRNA for EPS15

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001981

REFSEQ mRNAs for EPS15 gene (2 alternative transcripts):

NM_001159969.1 NM_001981.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001981

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001981
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001981
                                 untagged cDNA clone in CMV expression vector: NM_001981

Additional cDNA sequence:

AF052132.1 AK090936.1 AK129853.1 AK294297.1 AK308128.1 AK313396.1 BC054006.1 BX647676.1

DQ367924.1 U07707.1 Z29064.1 Z29070.1

11 DOTS entries:

DT.100777918 DT.447690 DT.95290133 DT.95290139 DT.100008201 DT.99946098 DT.95290125 DT.95290138

DT.100737445 DT.91771128 DT.97779149

24/287 AceView cDNA sequences (see all 287 ):

BM907204 AI003407 AA331589 CR599353 BU742017 BQ224263 AA195277 AA490223

AI472645 AI652123 BF795094 AW473360 BM725122 BM681433 AI208237 BF059527

D87737 AK129853 AA258562 BM765791 BE550950 F10989 AF052132 BX340738

highest scoring ESTs for EPS15:

AA832056 AA837424 AI138998 AI936583 AW340591 BC054006 BM149425 BU155626 U07707 Z29064

Unigene Cluster for EPS15:

Epidermal growth factor receptor pathway substrate 15

Hs.83722 [show with all ESTs]

Unigene Representative Sequence: NM_001981

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for EPS15

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18a	·	18b	^	19	^	20	^	21	^	22	^	23	^
SP1:					-		-		-																-										-
SP2:					-		-		-																-										-								-		-
SP3:																																									-		-
SP4:					-		-		-
SP5:

ExUns:	24	^	25	^	26	^	27	^	28	^	29
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for EPS15

5 Ensembl transcripts including schematic representations:

ENST00000371733 ENST00000396118 ENST00000371727 ENST00000371730 ENST00000396122

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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EPS15 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EPS15

¹ / ² / ³

7 probe-sets matching EPS15 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37731_at²^{, 3}	U95-A	1	1.00	1.00	0.59	1.14	Z29064	0.80	1.00	0.91	1
78641_at²^{, 3}	U95-E	1	1.00	1.00	0.91	1.21	AI138998	0.80	1.00	0.91	1
68123_at²^{, 3}	U95-E	1	0.56	1.00	0.48	0.66	R76875	0.60	1.00	0.82	1
217886_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF213575	0.60	1.00	0.82	1
217887_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001981	0.60	1.00	0.82	1
217886_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217887_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGTGTCCAA

SOURCE GeneReport for Unigene cluster: Hs.83722
Expression variation in blood from EXPOLDB for EPS15
UniProtKB/Swiss-Prot: EPS15_HUMAN, P42566
Tissue specificity: Ubiquitously expressed

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for EPS15 gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	EPS15¹	--	epidermal growth factor receptor pathway substrate more	93.23(n) 93.69(a)	475356 XM_532580.2 XP_532580.2
chimpanzee (Pan troglodytes)	EPS15¹	--	epidermal growth factor receptor pathway substrate more	99.55(n) 99.55(a)	456850 XM_001139238.1 XP_001139238.1
cow (Bos taurus)	EPS15¹	--	epidermal growth factor receptor pathway substrate more	93.35(n) 93.85(a)	535998 XM_616116.3 XP_616116.3
rat (Rattus norvegicus)	Eps15¹	--	epidermal growth factor receptor pathway substrate more	89(n) 89.3(a)	313474 NM_001009424.1 NP_001009424.1
mouse (Mus musculus)	Eps15^{1, 5}	4⁵	epidermal growth factor receptor pathway substrate more^{1, 5}	89.45(n)¹ 89.6(a)¹	13858¹ NM_007943.2¹ NP_031969.1¹ AK010764⁵ AK083176⁵ (see all 17)

About this table Species with no ortholog for EPS15

ENSEMBL Gene Tree for EPS15

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for EPS15 gene

ITSN1² EPS15L1² ITSN2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/876 NCBI SNPs in EPS15 are shown (see all 876 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 157)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7308^1,2	A,C,F,H,O	51593578(-)	`GGTCAA/CCAAGT`	1	--	ut3¹ ese³		6		MN EU EA WA	790
	rs17567^1,2	A,C,F,H	51599509(+)	`CAAAAT/CATTTC`	1	M/I	mis¹		15		MN EU EA WA NA	1386
	rs12088459^1,2	F,H	51759268(+)	`TACTTT/CATATT`	1	--	ng3¹ tfbs³		4		EU EA WA	416
--	rs4291542^1,2	H	51758515(+)	`AAGGCC/TTTCGT`	1	--	ng3¹		4		EU EA WA	410
	rs4926893^1,2	H	51709956(+)	`TGTTTG/TTTCAG`	1	N/K	mis¹		4		EU EA WA	418
	rs12130^1,2	C	51593001(+)	`GTCCAC/TGGGGT`	1	--	ut3¹		0	--	--	--	--
	rs1065754^1,2	A,C,F,H,O	51646539(-)	`ACTTAT/CGAAGA`	1	Y/Y	syn¹ ese³		9		MN NA EU EA WA	784
	rs34704431^1,2	C,F	51685348(-)	`CCTGCA/CGAAAA`	1	A/A	syn¹		1		NA	76
	rs35371705^1,2	C	51685282(-)	`TCTGGA/GTTGGA`	1	G/G	syn¹		1		NA	76
	rs12121478^1,2	H	51595083(+)	`CATTCG/AATCAT`	1	I/I	syn¹ ese³		4		EU EA WA	412

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HapMap Linkage Disequilibrium images for EPS15 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600051

UniProtKB/Swiss-Prot: EPS15_HUMAN, P42566

A chromosomal aberration involving EPS15 is found in acute leukemias. Translocation

t(1;11)(p32;q23) with MLL/HRX. The result is a rogue activator protein

2 Novoseek disease relationships for EPS15 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
down syndrome	13.87	1	14525795 (1)
tumors	0.00	2	7791787 (1), 10481267 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/157 PubMed articles for EPS15 gene (see all 157 ):

The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31-p32. (PubMed id 8183552)^{1, 2, 3, 4} Wong W.T.... di Fiore P.P. (1994)
An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor. (PubMed id 18362181)^{1, 3, 4} Roxrud I....Stenmark H. (2008)
STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. (PubMed id 12551915)^{1, 3, 4} Bache K.G....Stenmark H. (2003)
Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis. (PubMed id 9723620)^{1, 3, 4} Chen H.... De Camilli P. (1998)
Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain. (PubMed id 9721102)^{1, 3, 4} de Beer T.... Overduin M. (1998)
Solution structure of Eps15's third EH domain reveals coincident Phe- Trp and Asn-Pro-Phe binding sites. (PubMed id 10757979)^{1, 3, 4} Enmon J.L.... Overduin M. (2000)
Molecular mechanism of NPF recognition by EH domains. (PubMed id 11062555)^{1, 3, 4} de Beer T.... Overduin M. (2000)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2060	HGNC: 3419	AceView: EPS15	Ensembl:ENSG00000085832	euGenes: HUgn2060
ECgene: EPS15	H-InvDB: EPS15

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for EPS15	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for EPS15
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for EPS15:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for EPS15-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for EPS15		Antibodies for EPS15
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for EPS15		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
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	Antibodies (EPS15)

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Antibodies for EPS15

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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EPS15 Gene at Home site.
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EPS15 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for EPS15

Summaries
for EPS15

Genomic Location
for EPS15

Proteins
for EPS15

Protein Domains/
Families
for EPS15

Gene Function
for EPS15

Pathways & Interactions
for EPS15

Drugs & Compounds
for EPS15

Transcripts
for EPS15

Expression
for EPS15

Orthologs
for EPS15

Paralogs
for EPS15

SNPs/Variants
for EPS15

Disorders & Mutations
for EPS15

Medical News
for EPS15

Publications
for EPS15

Search for EPS15

Genome Databases showing EPS15

Other Databases showing EPS15

Specialized Databases showing EPS15

Licensable Technologies
for EPS15

Services
for EPS15

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EPS15 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor EPS15

Summariesfor EPS15

Genomic Locationfor EPS15

Proteinsfor EPS15

Protein Domains/Familiesfor EPS15

Gene Functionfor EPS15

Pathways & Interactionsfor EPS15

Drugs & Compoundsfor EPS15

Transcriptsfor EPS15

Expression for EPS15

Orthologsfor EPS15

Paralogsfor EPS15

SNPs/Variantsfor EPS15

Disorders & Mutationsfor EPS15

Medical Newsfor EPS15

Publicationsfor EPS15

Search for EPS15

Genome Databases showing EPS15

Other Databases showing EPS15

Specialized Databases showing EPS15

Licensable Technologiesfor EPS15

Servicesfor EPS15

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EPS15

Summaries
for EPS15

Genomic Location
for EPS15

Proteins
for EPS15

Protein Domains/
Families
for EPS15

Gene Function
for EPS15

Pathways & Interactions
for EPS15

Drugs & Compounds
for EPS15

Transcripts
for EPS15

Expression
for EPS15

Orthologs
for EPS15

Paralogs
for EPS15

SNPs/Variants
for EPS15

Disorders & Mutations
for EPS15

Medical News
for EPS15

Publications
for EPS15

Licensable Technologies
for EPS15

Services
for EPS15