Aliases for EPS15 Gene
Aliases for EPS15 Gene
External Ids for EPS15 Gene
- HGNC: 3419
- Entrez Gene: 2060
- Ensembl: ENSG00000085832
- OMIM: 600051
- UniProtKB: P42566
Previous GeneCards Identifiers for EPS15 Gene
- GC01M050709
- GC01M051179
- GC01M051190
- GC01M051532
- GC01M051819
- GC01M049937
Summaries for EPS15 Gene
-
This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009]
GeneCards Summary for EPS15 Gene
EPS15 (Epidermal Growth Factor Receptor Pathway Substrate 15) is a Protein Coding gene. Diseases associated with EPS15 include Vaccinia. Among its related pathways are Notch signaling pathway (KEGG) and HIV Life Cycle. GO annotations related to this gene include calcium ion binding and SH3 domain binding. An important paralog of this gene is EPS15L1.
UniProtKB/Swiss-Prot for EPS15 Gene
-
Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPS15 Gene
Genomics for EPS15 Gene
Regulatory Elements for EPS15 Gene
Enhancers for EPS15 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around EPS15 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the EPS15 gene promoter:
Regulatory Element Products
Genomic Location for EPS15 Gene
- Chromosome:
- 1
- Start:
- 51,354,263 bp from pter
- End:
- 51,519,354 bp from pter
- Size:
- 165,092 bases
- Orientation:
- Minus strand
Genomic View for EPS15 Gene
Genes around EPS15 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p32.3 by Ensembl
- 1p32.3 by Entrez Gene
- 1p32.3 by HGNC
EPS15 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EPS15 Gene
Proteins for EPS15 Gene
-
Protein details for EPS15 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P42566-EPS15_HUMAN
- Recommended name:
- Epidermal growth factor receptor substrate 15
- Protein Accession:
- P42566
- B2R8J7
- D3DPJ2
- Q5SRH4
Protein attributes for EPS15 Gene
- Size:
- 896 amino acids
- Molecular mass:
- 98656 Da
- Quaternary structure:
-
- Interacts with SGIP1 (PubMed:26822536). Interacts with HGS; the interaction bridges the interaction of STAM or STAM2 with EPS15. Isoform 2 interacts with HGS and AP2A2. Part of a complex at least composed of EPS15, HGS, and either STAM or STAM2. Binds AP2A2. Interacts with AP2B1; clathrin competes with EPS15. Binds STON2 and EPN1. Interacts (via its SH3-binding sites) with CRK. Interacts with SH3BP4/TTP. Interacts with ERBB2. Interacts with FCHO1. Interacts with FCHO2. Interacts (via EH domains) with DAB2. Interacts (via UIM repeats) with CORO7 (when ubiquitinated at Lys-472). Interacts (via UIM domains) with UBQLN1 (via ubiquitin-like domain) and can interact with both the ubiquitinated and the non-ubiquitinated forms of UBQLN1. Interacts with UBQLN2 (By similarity) (PubMed:10757979, PubMed:11062555, PubMed:12551915, PubMed:16159959, PubMed:16314522, PubMed:16325581, PubMed:16903783, PubMed:18199683, PubMed:18200045, PubMed:18362181, PubMed:20448150, PubMed:21762413, PubMed:22484487, PubMed:22648170, PubMed:24768539, PubMed:8662907, PubMed:9721102, PubMed:9723620). Interacts with vaccinia virus protein A36 (PubMed:27670116).
- (Microbial infection) Interacts with vaccinia virus protein A36 (PubMed:27670116).
Three dimensional structures from OCA and Proteopedia for EPS15 Gene
Protein Expression for EPS15 Gene
Post-translational modifications for EPS15 Gene
- Phosphorylation on Tyr-849 is involved in the internalization of EGFR. Not required for membrane translocation after EGF treatment or for targeting to coated pits, but essential for a subsequent step in EGFR endocytosis (By similarity). Phosphorylated on serine upon DNA damage, probably by ATM or ATR.
- Ubiquitinated.
- Ubiquitination at isoforms=2413, Lys495, isoforms=2638, Lys754, isoforms=2801, isoforms=2818, isoforms=2860, and Lys890
- Modification sites at PhosphoSitePlus
Other Protein References for EPS15 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for EPS15 (Eps15)
- Cell Signaling Technology (CST) Antibodies for EPS15 (EPS15)
-
Custom Antibody ServicesOriGene Antibodies for EPS15
- Novus Biologicals Antibodies for EPS15
-
Abcam antibodies for EPS15
- Invitrogen Antibodies for EPS15
- antibodies-online Antibodies for EPS15: See all 59
- GeneTex EPS15 antibody for EPS15
-
Santa Cruz Biotechnology (SCBT) Antibodies for EPS15
Protein Products
-
OriGene Purified Proteins for EPS15
- Search Origene for MassSpec and Protein Over-expression Lysates for EPS15
- Origene Custom Protein Services for EPS15
- Search GeneTex for Proteins for EPS15
Assay Products
- antibodies-online Kits for EPS15: See all 2
No data available for DME Specific Peptides for EPS15 Gene
Domains & Families for EPS15 Gene
Gene Families for EPS15 Gene
Protein Domains for EPS15 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for EPS15 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P42566UniProtKB/Swiss-Prot:
EPS15_HUMAN :- The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins.
- Domain:
-
- The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins.
- The UIM (ubiquitin-interacting motif) repeats specifically bind Lys-33-linked ubiquitin.
Function for EPS15 Gene
Molecular function for EPS15 Gene
- GENATLAS Biochemistry:
- EGFR pathway substrate,mouse eps15 homolog,likely involved in cell growth regulation
- UniProtKB/Swiss-Prot Function:
- Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 10064583 |
| GO:0017124 | SH3 domain binding | IEA | -- |
| GO:0031593 | polyubiquitin binding | IDA | 24768539 |
| GO:0042802 | identical protein binding | IEA | -- |
Phenotypes for EPS15 Gene
- MGI mutant phenotypes for EPS15:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for EPS15:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for EPS15
-
-
ViGene Biosciences lentiviral particle packaged cDNA for EPS15 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EPS15 gene
- Search ViGene Biosciences for EPS15
CRISPR Products
-
OriGene CRISPR knockouts for EPS15
-
Santa Cruz Biotechnology (SCBT) CRISPR for EPS15
- GenScript: Design CRISPR guide RNA sequences for EPS15
miRNA for EPS15 Gene
- miRTarBase miRNAs that target EPS15
miRNA Products
- Search ViGene Biosciences for EPS15
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for EPS15
- Browse OriGene Inhibitory RNA Products For EPS15
-
ViGene Biosciences ready-to-package AAV shRNAs for EPS15 gene
Clone Products
- Sino Biological Human cDNA Clone for EPS15
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for EPS15
- VectorBuilder custom plasmid, inducible vectors for EPS15
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EPS15
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for EPS15
-
ViGene Biosciences adenoviral particle packaged cDNA for EPS15 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for EPS15 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EPS15 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EPS15 Gene
Localization for EPS15 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EPS15 Gene
- Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic juxtanuclear structures called aggresomes. {ECO:0000269 PubMed:16159959}.
- Isoform 2: Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with HGS on bilayered clathrin coats on endosomes.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| endosome | 4 |
| nucleus | 3 |
| cytoskeleton | 2 |
| lysosome | 2 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005768 | endosome | IEA | -- |
| GO:0005769 | early endosome | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IDA | 15465819 |
Pathways & Interactions for EPS15 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Listeria monocytogenes entry into host cells | ||
| 2 | Clathrin-mediated endocytosis | ||
| 3 | HIV Life Cycle |
.45
|
|
| 4 | Vesicle-mediated transport | ||
| 5 | Delta508-CFTR traffic / ER-to-Golgi in CF | ||
Pathways by source for EPS15 Gene
1 Cell Signaling Technology pathway for EPS15 Gene
4 BioSystems pathways for EPS15 Gene
13 Reactome pathways for EPS15 Gene
1 KEGG pathway for EPS15 Gene
2 GeneGo (Thomson Reuters) pathways for EPS15 Gene
1 Qiagen pathway for EPS15 Gene
Interacting Proteins for EPS15 Gene
Selected Interacting proteins:
ENSP00000360798
P42566-EPS15_HUMAN
for EPS15 Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001921 | positive regulation of receptor recycling | IEA | -- |
| GO:0006810 | transport | IEA | -- |
| GO:0006895 | Golgi to endosome transport | IMP | 24768539 |
| GO:0006897 | endocytosis | IEA | -- |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | 8183552 |
Transcripts for EPS15 Gene
mRNA/cDNA for EPS15 Gene
- (9) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (287) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for EPS15 Gene
CRISPR Products
-
OriGene CRISPR knockouts for EPS15
-
Santa Cruz Biotechnology (SCBT) CRISPR for EPS15
- GenScript: Design CRISPR guide RNA sequences for EPS15
miRNA Products
- Search ViGene Biosciences for EPS15
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for EPS15
- Browse OriGene Inhibitory RNA Products For EPS15
-
ViGene Biosciences ready-to-package AAV shRNAs for EPS15 gene
Clone Products
- Sino Biological Human cDNA Clone for EPS15
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for EPS15
- VectorBuilder custom plasmid, inducible vectors for EPS15
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EPS15
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: |
| ExUns: | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | |||||||||||
| SP3: | |||||||||||
| SP4: | |||||||||||
| SP5: |
Expression for EPS15 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (26.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EPS15 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of EPS15 Gene:
EPS15SOURCE GeneReport for Unigene cluster for EPS15 Gene:
Hs.83722mRNA Expression by UniProt/SwissProt for EPS15 Gene:
P42566-EPS15_HUMAN
Tissue specificity:
Ubiquitously expressed.
Evidence on tissue expression from TISSUES for EPS15 Gene
- Blood(4.4)
- Liver(4.4)
- Nervous system(4.4)
- Kidney(2.4)
- Heart(2.1)
- Muscle(2.1)
Primer Products
-
OriGene qPCR primer pairs for EPS15
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EPS15 Gene
Orthologs for EPS15 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | EPS15 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | EPS15 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | EPS15 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Eps15 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Eps15 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | EPS15 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | EPS15 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | EPS15 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | EPS15 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | eps15 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | eps15 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Eps-15 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | ehs-1 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | EDE1 35 37 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for EPS15 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for EPS15 Gene
Variants for EPS15 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000030446 | -- | 51,366,182(+) | CCCAC(A/C)TCAGC | intron-variant | |
| rs1000048607 | -- | 51,390,386(+) | TCACC(A/G)TTCAG | intron-variant | |
| rs1000074831 | -- | 51,512,423(+) | GCTCT(-/AAGAG)AAAAG | intron-variant | |
| rs1000084386 | -- | 51,437,223(+) | CAAAG(A/G)ACATT | intron-variant | |
| rs1000092260 | -- | 51,366,405(+) | ATCAC(A/G)TTCAG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv25434 | CNV | loss | 19812545 |
| esv2659806 | CNV | deletion | 23128226 |
| esv3307818 | CNV | mobile element insertion | 20981092 |
| esv3308869 | CNV | mobile element insertion | 20981092 |
| esv3363534 | CNV | insertion | 20981092 |
| esv3367601 | CNV | duplication | 20981092 |
| esv3422673 | CNV | insertion | 20981092 |
| esv3577854 | CNV | loss | 25503493 |
| esv3577855 | CNV | loss | 25503493 |
| esv3586035 | CNV | loss | 21293372 |
| esv3586036 | CNV | loss | 21293372 |
| nsv1077820 | CNV | deletion | 25765185 |
| nsv478230 | CNV | novel sequence insertion | 20440878 |
Residual Variation Intolerance Score:
43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.45;
88.65% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for EPS15 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPS15 Gene
Disorders for EPS15 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| vaccinia |
|
|
Search EPS15 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
EPS15_HUMAN- Note=A chromosomal aberration involving EPS15 is found in acute leukemias. Translocation t(1;11)(p32;q23) with KMT2A/MLL1. The result is a rogue activator protein.
Relevant External Links for EPS15
No data available for Genatlas for EPS15 Gene
Publications for EPS15 Gene
- The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31-p32. (PMID: 8183552) Wong W.T. … di Fiore P.P. (Oncogene 1994) 2 3 4 22 64
- An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor. (PMID: 18362181) Roxrud I. … Stenmark H. (J. Cell Biol. 2008) 3 4 22 64
- STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. (PMID: 12551915) Bache K.G. … Stenmark H. (J. Biol. Chem. 2003) 3 4 22 64
- Solution structure of Eps15's third EH domain reveals coincident Phe- Trp and Asn-Pro-Phe binding sites. (PMID: 10757979) Enmon J.L. … Overduin M. (Biochemistry 2000) 3 4 22 64
- Molecular mechanism of NPF recognition by EH domains. (PMID: 11062555) de Beer T. … Overduin M. (Nat. Struct. Biol. 2000) 3 4 22 64
Products for EPS15 Gene
- R&D Systems Antibodies for EPS15 (Eps15)
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- Custom Antibody ServicesOriGene Antibodies for EPS15
- Browse OriGene ELISA Kits
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for EPS15
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- GenScript: Next-day shipping cDNA ORF clone for EPS15 in any vector
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- GenScript: Design CRISPR guide RNA sequences for EPS15
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- Cell Signaling Technology (CST) Antibodies for EPS15 (EPS15)
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- Sino Biological Human cDNA Clone for EPS15
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- Novus Biologicals proteins and lysates for EPS15
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for EPS15
- Find your target
- Search knockout validated antibodies
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- Invitrogen Antibodies for EPS15
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for EPS15
- antibodies-online Antibodies for EPS15: See all 59
- antibodies-online Kits for EPS15: See all 2
- Search antibodies-online for proteins
- Search antibodies-online for peptides
- GeneTex EPS15 antibody for EPS15
- Search GeneTex for Proteins for EPS15
- ViGene Biosciences adenoviral particle packaged cDNA for EPS15 gene
- ViGene Biosciences lentiviral particle packaged cDNA for EPS15 gene
- ViGene Biosciences ready-to-package AAV shRNAs for EPS15 gene
- Search ViGene Biosciences for EPS15
- Santa Cruz Biotechnology (SCBT) Antibodies for EPS15
- Search Santa Cruz Biotechnology (SCBT) for EPS15 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EPS15
- Horizon Cell Lines for EPS15
- Cyagen custom Knockout/knockin (KOKI) mouse models for EPS15
- VectorBuilder custom plasmid, inducible vectors for EPS15
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EPS15
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for EPS15 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
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- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
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- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
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- (37) SGD
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- (40) Pseudogene
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- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
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- (60) miRBase
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- (62) NCBI
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- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
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- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
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- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
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- (140) FANTOM5
- (141) ENCODE
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- (143) Horizon
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- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer