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Aliases for EPRS Gene

Aliases for EPRS Gene

  • Glutamyl-Prolyl-TRNA Synthetase 2 3 5
  • Cell Proliferation-Inducing Gene 32 Protein 3 4
  • Bifunctional Aminoacyl-TRNA Synthetase 3 4
  • Glutamatyl-Prolyl-TRNA Synthetase 3 4
  • Glutamate TRNA Ligase 2 3
  • Proline TRNA Ligase 2 3
  • QARS 3 4
  • QPRS 3 4
  • PARS 3 4
  • Proliferation-Inducing Gene 32 Protein 3
  • Proliferation-Inducing Protein 32 3
  • Glutaminyl-TRNA Synthetase 3
  • Prolyl-TRNA Synthetase 3
  • Proline-TRNA Ligase 3
  • EC 6.1.1.15 63
  • EC 6.1.1.18 63
  • GLUPRORS 3
  • EC 6.1.1 63
  • PIG32 3
  • EARS 3
  • GLNS 4

External Ids for EPRS Gene

Previous HGNC Symbols for EPRS Gene

  • QPRS
  • QARS

Previous GeneCards Identifiers for EPRS Gene

  • GC01M218738
  • GC01M215985
  • GC01M216688
  • GC01M217198
  • GC01M216530
  • GC01M218208
  • GC01M220141
  • GC01M190816

Summaries for EPRS Gene

Entrez Gene Summary for EPRS Gene

  • Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for EPRS Gene

EPRS (Glutamyl-Prolyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with EPRS include allergic encephalomyelitis and melkersson-rosenthal syndrome. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include nucleotide binding and GTPase binding.

UniProtKB/Swiss-Prot for EPRS Gene

  • Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.

Gene Wiki entry for EPRS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPRS Gene

Genomics for EPRS Gene

Regulatory Elements for EPRS Gene

Promoters for EPRS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EPRS on UCSC Golden Path with GeneCards custom track

Genomic Location for EPRS Gene

Chromosome:
1
Start:
219,968,600 bp from pter
End:
220,046,658 bp from pter
Size:
78,059 bases
Orientation:
Minus strand

Genomic View for EPRS Gene

Genes around EPRS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPRS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPRS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPRS Gene

Proteins for EPRS Gene

  • Protein details for EPRS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07814-SYEP_HUMAN
    Recommended name:
    Bifunctional glutamate/proline--tRNA ligase
    Protein Accession:
    P07814
    Secondary Accessions:
    • A0AVA9
    • B9EGH3
    • Q05BP6
    • Q05DF8
    • Q5DSM1
    • Q5H9S5
    • Q6PD57
    • Q86X73

    Protein attributes for EPRS Gene

    Size:
    1512 amino acids
    Molecular mass:
    170591 Da
    Quaternary structure:
    • Component of the multisynthetase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthetase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA synthetases as well as three auxiliary proteins, p18, p48 and p43. Interacts with DUS2L. Component of the GAIT complex; in humans the complex assembly seems to be a two-step process in which EPRS first associates with SYNCRIP to form a pre-GAIT complex which is deficient in GAIT element binding.
    SequenceCaution:
    • Sequence=AAH15494.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH34797.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH46156.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH58921.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAS72877.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA30354.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=CAA38224.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EPRS Gene

neXtProt entry for EPRS Gene

Proteomics data for EPRS Gene at MOPED

Selected DME Specific Peptides for EPRS Gene

Post-translational modifications for EPRS Gene

  • Phosphorylated at Ser-886 by CDK5 and at Ser-999 by an unknown kinase in a IFN-gamma-dependent manner in monocytes; these sequential phosphorylations are causing release from the multisynthetase complex, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition. Phosphorylation at Ser-999 is specifically required for the interaction of GAIT complex-associated RPL13A with eIF4G.
  • Ubiquitination at Lys 229, Lys 435, Lys 472, Lys 535, Lys 782, Lys 861, Lys 943, Lys 1132, Lys 1143, Lys 1375, Lys 1435, and Lys 1503
  • Modification sites at PhosphoSitePlus

Other Protein References for EPRS Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for EPRS Gene

Suggested Antigen Peptide Sequences for EPRS Gene

Graphical View of Domain Structure for InterPro Entry

P07814

UniProtKB/Swiss-Prot:

SYEP_HUMAN :
  • The WHEP-TRS domain is involved in RNA binding.
  • In the N-terminal section; belongs to the class-I aminoacyl-tRNA synthetase family.
Domain:
  • The WHEP-TRS domain is involved in RNA binding.
  • Contains 3 WHEP-TRS domains.
Family:
  • In the N-terminal section; belongs to the class-I aminoacyl-tRNA synthetase family.
  • In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with EPRS: view

Function for EPRS Gene

Molecular function for EPRS Gene

GENATLAS Biochemistry:
glutamyl-prolyl-tRNA synthetase
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).
UniProtKB/Swiss-Prot Function:
Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.

Enzyme Numbers (IUBMB) for EPRS Gene

Gene Ontology (GO) - Molecular Function for EPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004812 aminoacyl-tRNA ligase activity IEA --
GO:0051020 GTPase binding IPI 24337748
genes like me logo Genes that share ontologies with EPRS: view
genes like me logo Genes that share phenotypes with EPRS: view

Animal Models for EPRS Gene

MGI Knock Outs for EPRS:
  • Eprs tm1b(EUCOMM)Hmgu

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EPRS Gene

Localization for EPRS Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPRS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPRS Gene COMPARTMENTS Subcellular localization image for EPRS gene
Compartment Confidence
cytosol 5
extracellular 2
mitochondrion 2
nucleus 2
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for EPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with EPRS: view

Pathways & Interactions for EPRS Gene

genes like me logo Genes that share pathways with EPRS: view

Pathways by source for EPRS Gene

SIGNOR curated interactions for EPRS Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for EPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly TAS 8188258
GO:0010467 gene expression TAS --
GO:0043039 tRNA aminoacylation IEA --
genes like me logo Genes that share ontologies with EPRS: view

Drugs & Compounds for EPRS Gene

(22) Drugs for EPRS Gene - From: Novoseek, HMDB, DrugBank, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Proline Approved Nutra Target 0
Famotidine Approved Pharma Histamine H2-receptor antagonist 57
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
'5'-O-(N-(L-Alanyl)-Sulfamoyl)Adenosine Experimental Pharma Target 0

(26) Additional Compounds for EPRS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with EPRS: view

Transcripts for EPRS Gene

Unigene Clusters for EPRS Gene

Glutamyl-prolyl-tRNA synthetase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EPRS Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a ·
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9: - - -
SP10: -
SP11:
SP12:
SP13:
SP14: -
SP15:
SP16: -
SP17:

ExUns: 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35a ·
SP1:
SP2:
SP3:
SP4: -
SP5: -
SP6: -
SP7:
SP8: -
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

ExUns: 35b ^ 36a · 36b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for EPRS Gene

GeneLoc Exon Structure for
EPRS
ECgene alternative splicing isoforms for
EPRS

Expression for EPRS Gene

mRNA expression in normal human tissues for EPRS Gene

Protein differential expression in normal tissues from HIPED for EPRS Gene

This gene is overexpressed in Lymph node (9.0) and Salivary gland (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EPRS Gene



SOURCE GeneReport for Unigene cluster for EPRS Gene Hs.497788

genes like me logo Genes that share expression patterns with EPRS: view

Protein tissue co-expression partners for EPRS Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EPRS Gene

Orthologs for EPRS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EPRS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EPRS 35
  • 99.6 (n)
  • 99.6 (a)
EPRS 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EPRS 36
  • 92 (a)
OneToOne
EPRS 35
  • 90.49 (n)
  • 92.39 (a)
dog
(Canis familiaris)
Mammalia EPRS 35
  • 91.92 (n)
  • 93.44 (a)
EPRS 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eprs 16
Eprs 35
  • 86.16 (n)
  • 89.42 (a)
Eprs 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EPRS 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Eprs 35
  • 85.1 (n)
  • 87.87 (a)
chicken
(Gallus gallus)
Aves EPRS 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EPRS 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21378 35
tropical clawed frog
(Silurana tropicalis)
Amphibia eprs 35
  • 71.24 (n)
  • 76.89 (a)
Str.1851 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14111 35
zebrafish
(Danio rerio)
Actinopterygii eprs 36
  • 66 (a)
OneToOne
eprs 35
  • 68.23 (n)
  • 74.15 (a)
wufb06c03 35
fruit fly
(Drosophila melanogaster)
Insecta Aats-glupro 37
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea ers-2 37
  • 49 (a)
prs-1 37
  • 53 (a)
ears-1 36
  • 43 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR264W 35
  • 52.55 (n)
  • 47.94 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GUS1 35
  • 54.66 (n)
  • 48.45 (a)
GUS1 36
  • 42 (a)
OneToOne
-- 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A00682g 35
  • 54.61 (n)
  • 49.18 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5281 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G26710 35
  • 52.18 (n)
  • 43.9 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.4312 35
corn
(Zea mays)
Liliopsida Zm.3156 35
rice
(Oryza sativa)
Liliopsida Os.6059 35
Os01g0271200 35
  • 53.75 (n)
  • 45.18 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08894 35
  • 49.64 (n)
  • 43.95 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC17A5.15c 35
  • 53.49 (n)
  • 48.69 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14752 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11263 36
  • 55 (a)
OneToOne
Species with no ortholog for EPRS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EPRS Gene

ENSEMBL:
Gene Tree for EPRS (if available)
TreeFam:
Gene Tree for EPRS (if available)

Paralogs for EPRS Gene

(1) SIMAP similar genes for EPRS Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with EPRS: view

No data available for Paralogs for EPRS Gene

Variants for EPRS Gene

Sequence variations from dbSNP and Humsavar for EPRS Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs35999099 - 220,024,321(-) CTCCT(C/G)CTGAA reference, missense
rs2230301 - 220,024,283(-) ATAGA(A/C)TCTAA reference, missense
rs1063236 - 220,022,460(-) GGTCA(C/G)TCCTG reference, missense
rs5030751 - 219,988,687(-) TGAAC(A/C)TGCTG reference, missense
rs5030752 - 219,983,362(-) ATGAC(A/G)TAAGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for EPRS Gene

Variant ID Type Subtype PubMed ID
nsv832636 CNV Loss 17160897
nsv819514 CNV Loss 19587683
esv9238 CNV Gain 19470904
esv1351321 CNV Insertion 17803354
esv5550 CNV Gain 19470904
nsv4632 CNV Insertion 18451855

Variation tolerance for EPRS Gene

Residual Variation Intolerance Score: 2.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.75; 73.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EPRS Gene

HapMap Linkage Disequilibrium report
EPRS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPRS Gene

Disorders for EPRS Gene

MalaCards: The human disease database

(3) MalaCards diseases for EPRS Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
allergic encephalomyelitis
  • experimental autoimmune encephalomyelitis
melkersson-rosenthal syndrome
  • cheilitis granulomatosa of mescher-melkersson-rosenthal
separation anxiety disorder
  • separation anxiety disorder of childhood
- elite association - COSMIC cancer census association via MalaCards
Search EPRS in MalaCards View complete list of genes associated with diseases

Relevant External Links for EPRS

Genetic Association Database (GAD)
EPRS
Human Genome Epidemiology (HuGE) Navigator
EPRS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EPRS
genes like me logo Genes that share disorders with EPRS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EPRS Gene

Publications for EPRS Gene

  1. The primary structure of human glutaminyl-tRNA synthetase. A highly conserved core, amino acid repeat regions, and homologies with translation elongation factors. (PMID: 1988429) Fett R. … Knippers R. (J. Biol. Chem. 1991) 2 3 4 67
  2. Evolution of the aminoacyl-tRNA synthetase family and the organization of the Drosophila glutamyl-prolyl-tRNA synthetase gene. Intron/exon structure of the gene, control of expression of the two mRNAs, selective advantage of the multienzyme complex. (PMID: 9063462) Cerini C. … Gratecos D. (Eur. J. Biochem. 1997) 23 25 26
  3. Two-site phosphorylation of EPRS coordinates multimodal regulation of noncanonical translational control activity. (PMID: 19647514) Arif A. … Fox P.L. (Mol. Cell 2009) 3 23
  4. WHEP domains direct noncanonical function of glutamyl-Prolyl tRNA synthetase in translational control of gene expression. (PMID: 18374644) Jia J. … Fox P.L. (Mol. Cell 2008) 3 23
  5. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26

Products for EPRS Gene

Sources for EPRS Gene

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