EPRS Gene
protein-coding GIFtS: 66
GCID: GC01M220141
|
|
glutamyl-prolyl-tRNA synthetase
(Previous symbols: QPRS, QARS)
| |
Aliases
for EPRS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Glutamyl-Prolyl-TRNA Synthetase1 2 | | Glutaminyl-TRNA Synthetase2 | | PARS1 2 3 5 | | Proliferation-Inducing Gene 32 Protein2 | | QARS1 2 3 | | Proliferation-Inducing Protein 322 | | QPRS1 2 3 | | Proline TRNA Ligase2 | | EARS1 2 | | Proline-TRNA Ligase2 | | GLUPRORS1 2 | | Prolyl-TRNA Synthetase2 | | Bifunctional Aminoacyl-TRNA Synthetase2 3 | | GLNS3 | | Cell Proliferation-Inducing Gene 32 Protein2 3 | | EC 6.1.18 | | Glutamatyl-Prolyl-TRNA Synthetase2 3 | | EC 6.1.1.158 | | Bifunctional Glutamate/Proline--TRNA Ligase2 | | EC 6.1.1.188 | | Glutamate TRNA Ligase2 | | |
Export aliases for EPRS gene to outside databasesPrevious GC identifers: GC01M218738 GC01M215985 GC01M216688 GC01M217198 GC01M216530 GC01M218208 GC01M190816 |
Summaries
for EPRS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for EPRS:
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encodedby this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid andproline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biologicalvalidity of the variant have not been determined. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SYEP_HUMAN, P07814Function: Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: theamino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptorend of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex whichmediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Uponinterferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assemblesinto the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs(such as ceruplasmin) and suppresses their translation
Gene Wiki entry for EPRS
|
Genomic Views
for EPRS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EPRS gene promoter:
STAT5B STAT1 STAT4 STAT2 STAT6 STAT3 STAT1beta STAT5A STAT1alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for EPRS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPRS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q41 Ensembl cytogenetic band: 1q41 HGNC cytogenetic band: 1q41EPRS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M220141: view genomic region
(about GC identifiers)
Start:
|
220,141,942 bp from pter |
End:
|
220,220,000 bp from pter |
Size:
|
78,059 bases |
Orientation:
|
minus strand |
|
Proteins
for EPRS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SYEP_HUMAN, P07814 (See
protein sequence)Recommended Name: Bifunctional glutamate/proline--tRNA ligase Size: 1512 amino acids; 170591 Da
Subunit: Component of the multisynthetase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthetase,the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA synthetases as well asthree auxiliary proteins, p18, p48 and p43. Interacts with DUS2L. Component of the GAIT complex; in humans the complexassembly seems to be a two-step process in which EPRS first associates with SYNCRIP to form a pre-GAIT complex whichis deficient in GAIT element binding
Subcellular location: Cytoplasm (Probable)
Caution: Was originally thought to be a glutaminyl-tRNA synthetase
Sequence caution: Sequence=AAH15494.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence; Sequence=AAH34797.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;Sequence=AAH46156.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;Sequence=AAH58921.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;Sequence=AAS72877.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA30354.1;Type=Miscellaneous discrepancy; Note=Sequencing errors; Sequence=CAA38224.1; Type=Erroneous initiation;Note=Translation N-terminally extended;
2 PDB 3D structures from  and Proteopedia  for EPRS:1FYJ (3D)
4HVC (3D)
Secondary accessions: A0AVA9 B9EGH3 Q05BP6 Q05DF8 Q5DSM1 Q5H9S5 Q6PD57 Q86X73Explore the universe of human proteins at neXtProt for EPRS: NX_P07814
Post-translational modifications:
Phosphorylated at Ser-886 by CDK5 and at Ser-999 by an unknown kinase in a IFN-gamma-dependent manner in monocytes;these sequential phosphorylations are causing release from the multisynthetase complex, association with the GAITcomplex and subsequent involvement in transcript-selective translation inhibition. Phosphorylation at Ser-999 isspecifically required for the interaction of GAIT complex-associated RPL13A with eIF4G1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P07814
4/8 DME Specific Peptides for EPRS (P07814) (see all 8)
EPRS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004437.2
ENSEMBL proteins: ENSP00000355890 Reactome Protein details: P07814
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
EPRS for ontologies About GeneDecksing
EPRS Antibody Products:
Assay Products for EPRS: |
Protein
Domains /
Families
for EPRS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EPRS for domains About GeneDecksing
5/18 InterPro domains/families (see all 18):Graphical View of Domain Structure for InterPro Entry P07814ProtoNet protein and cluster: P07814 4 Blocks protein families: IPB000738 WHEP-TRS domain IPB000924 Glutamyl-tRNA synthetase signature IPB002316 Prolyl-tRNA synthetase signature IPB004154 Anticodon binding domain
UniProtKB/Swiss-Prot: SYEP_HUMAN, P07814Domain: The WHEP-TRS domain is involved in RNA bindingSimilarity: In the N-terminal section; belongs to the class-I aminoacyl-tRNA synthetase familySimilarity: In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase familySimilarity: Contains 3 WHEP-TRS domains |
Function
for EPRS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SYEP_HUMAN, P07814Function: Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: theamino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptorend of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex whichmediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Uponinterferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assemblesinto the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs(such as ceruplasmin) and suppresses their translationCatalytic activity: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)Catalytic activity: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro) Genatlas biochemistry entry for EPRS:glutamyl-prolyl-tRNA synthetase
Enzyme Numbers (IUBMB): EC 6.1.1.182 EC 6.1.12 EC 6.1.1.152
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EPRS (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EPRS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: EPRS (NM_004446) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EPRS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPRS |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPRS |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
EPRS for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for EPRS:
|
Pathways & Interactions
for EPRS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | tRNA Aminoacylation | | | 2 | Glutamic acid signaling | | | 3 | Parkinsons Disease Pathway | | | 4 | Generic Transcription Pathway | | | 5 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for EPRS
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for EPRS
1  BioSystems Pathway for EPRS
3 
Reactome Pathways for EPRS
3 
Kegg Pathways (Kegg details for EPRS):
EPRS for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EPRS
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/237 Interacting proteins for EPRS (P078141, 2, 3 ENSP000003558904) via UniProtKB, MINT, STRING, and/or I2D (see all 237)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| IARS | P412521, 2, 3, ENSP000003647944 | EBI-355315,EBI-355303 MINT-15365 MINT-15364 I2D:
score=5 STRING: ENSP00000364794 | | NELFCD | Q8IXH72, 3, ENSP000003423004 | MINT-64854 I2D:
score=5 STRING: ENSP00000342300 | | IKBKB | O149202, 3, ENSP000003391514 | MINT-48073 I2D:
score=2 STRING: ENSP00000339151 | | NFKB2 | Q006532, 3, ENSP000001894444 | MINT-48714 I2D:
score=2 STRING: ENSP00000189444 | | RELB | Q012012, 3, ENSP000002214524 | MINT-48989 I2D:
score=2 STRING: ENSP00000221452 |
About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
EPRS for ontologies About GeneDecksing
|
Drugs & Compounds
for EPRS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
EPRS for compounds About GeneDecksing
 Browse Tocris compounds for EPRS
7 HMDB Compounds for EPRS About this table
5 DrugBank Compounds for EPRS About this table
10/37 Novoseek chemical compound relationships for EPRS gene (see all 37) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| 5-iodo-6-amino-1,2-benzopyrone |
87.3 |
8 |
9759901 (1), 9496941 (1), 9520459 (1), 11431007 (1) (see all 5) |
| 3-aminobenzamide |
74.5 |
32 |
9832385 (3), 9032115 (2), 9463632 (2), 9670921 (1) (see all 12) |
| adpribose |
73.6 |
20 |
9670921 (1), 10638671 (1), 15134512 (1), 11525764 (1) (see all 18) |
| peroxynitrite |
71.2 |
50 |
12412622 (6), 9239421 (5), 10188990 (5), 9520459 (4) (see all 23) |
| aminoacyl-trna |
70.9 |
6 |
17161369 (1), 8188258 (1), 9063462 (1), 9878398 (1) (see all 5) |
| gln-trna(gln) |
69.2 |
2 |
7783222 (1), 8078941 (1) |
| serine |
67.3 |
37 |
11448145 (2), 12645829 (1), 16951492 (1), 16903872 (1) (see all 32) |
| trna(gln) |
65.1 |
3 |
8078941 (1) |
| maba |
64.9 |
1 |
9832385 (1) |
| trna |
62.2 |
63 |
9556618 (3), 10913161 (3), 9283975 (3), 19647514 (2) (see all 17) |
Search CenterWatch for drugs/clinical trials and news about EPRS / SYEP
|
Transcripts
for EPRS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EPRS gene: NM_004446.2 Unigene Cluster for EPRS: Glutamyl-prolyl-tRNA synthetase Hs.497788 [show with all ESTs]Unigene Representative Sequence: NM_0044465 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000366923(uc001hly.1 uc010puf.1 uc001hlz.1 uc009xdt.1)
ENST00000468487 ENST00000485821 ENST00000464052 ENST00000477030
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EPRS (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EPRS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: EPRS (NM_004446) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EPRS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPRS |
Additional cDNA sequence: AK296755.1 AK298192.1 AK307534.1 AY493416.1 BC015494.1 BC034797.1 BC046156.1 BC058921.1 BC067841.1 BC105983.1 BC126275.1 BC136465.1 CR933648.1 JQ080075.1 X07466.1 X54326.1 20 DOTS entries: DT.92455592 DT.100881512 DT.95246333 DT.121404221 DT.319485 DT.100881516 DT.100881518 DT.95246331 DT.102832961 DT.121404223 DT.95246403 DT.95246408 DT.100734078 DT.100881515 DT.100881517 DT.121404199 DT.40207472 DT.92455590 DT.102832959 DT.121404201 24/564 AceView cDNA sequences (see all 564): BG325924 CA395324 AA330468 CB134641 BC034797 AA418438 H89225 AA232865 AI951332 AA968511 BM457833 BU542002 AU123220 NM_004446 BF062459 AI916204 CA425873 BQ423830 BU164198 CR622328 CB215419 CA418882 BQ006104 BM746163
GeneLoc Exon Structure
5/17 Alternative Splicing Database (ASD) splice patterns (SP) for EPRS (see all 17) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · |
|---|
|
| SP1: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | |
| SP4: | | | | | | | | | | | - | | | | - | | | | | | | | | | - | | - | | | | | | | | - | | | | - | | - | | - | | | | - | | - | | - | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 18b | ^ | 19 | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26a | · | 26b | ^ | 27a | · | 27b | ^ | 28a | · | 28b | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32a | · | 32b | ^ | 33 | ^ | 34 | ^ | 35a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 35b | ^ | 36a | · | 36b |
|---|
|
| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for EPRS
|
Expression
for EPRS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EPRS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACTAAAAAA
About this image
See EPRS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EPRS
SOURCE GeneReport for Unigene cluster: Hs.497788
SABiosciences Custom PCR Arrays for EPRS
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EPRS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EPRS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPRS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPRS | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPRS |
Orthologs
for EPRS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for EPRS gene from 11/44 species (see all 44) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Eprs1 , 5 |
glutamyl-prolyl-tRNA synthetase1, 5 |
86.16(n)1
89.42(a)1 |
|
1 (89.50 cM)5
1075081 NM_029735.11 NP_084011.11
1853630955 |
chicken
(Gallus gallus) |
Aves |
EPRS1 |
glutamyl-prolyl-tRNA synthetase |
77.4(n)
81.79(a) |
|
421348 NM_001006398.1 NP_001006398.1 |
lizard
(Anolis carolinensis) |
Reptilia |
EPRS6PARS26 |
-- |
77(a)15(a) |
1 ↔ 1possible ortholog |
1(243199593-243250983) 4(104460292-104461710) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.213782 |
Xenopus laevis transcribed sequence with strong similarity more |
76.15(n) |
|
BU909251.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb06c032 |
Transcribed sequence with moderate similarity to protein more |
77.4(n) |
|
CK236183.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Aats-glupro3 |
glutamyl-tRNA aminoacylation proline-tRNA
ligase |
52(a) |
|
95D1 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
prs-13 |
Prolyl-tRNA synthetase region |
53(a)
(best of 2) |
|
III(7310784-7312847) -- |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
(YHR020W)4
GUS11 |
Protein of unknown function that may interact with more4
Gus1p1 |
54.09(n)1
47.67(a)1 |
|
8(143996-146062)4
8526061 NP_011269.21 8564134
NP_011884.14 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G267101 |
glutamyl-tRNA synthetase |
52.46(n)
44.36(a) |
|
832718 NM_180543.2 NP_850874.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.60592 |
Rice mRNA for glutaminyl-tRNA synthetase, partial sequence |
73.8(n) |
|
AK104881.1 |
ENSEMBL Gene Tree for EPRS (if available)
TreeFam Gene Tree for EPRS (if available) |
Paralogs
for EPRS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for EPRS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EPRS (220141942 - 220220000 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for EPRS
3 Indels: 59984 58362 59983 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EPRS |
|
Disorders
/ Diseases
for EPRS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EPRS for disorders About GeneDecksing
OMIM gene information: 138295
OMIM disorders: --
20/48  diseases for EPRS (see all 48): About MalaCardsspinal cord injury q fever allergic encephalomyelitis encephalomyelitis
gastric ulcer arteriosclerosis brain injury rheumatoid arthritis
multiple sclerosis neurodegenerative disease antiphospholipid syndrome gaucher's disease
pleurisy appendicitis ischemia thrombosis
cystitis hepatocellular carcinoma prostate cancer neurodegeneration
10/44 Novoseek disease relationships for EPRS gene (see all 44) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| inflammation |
59.6 |
58 |
15051630 (3), 17397548 (3), 9683009 (3), 11239578 (2) (see all 41) |
| vascular ring |
47.1 |
1 |
12412622 (1) |
| thrombosis |
44.2 |
8 |
12161502 (1), 15707890 (1), 20131237 (1), 16332977 (1) (see all 8) |
| airways disease |
36.5 |
6 |
11448145 (2), 14633513 (2) |
| neurodegeneration |
28.5 |
3 |
16476770 (1), 17191106 (1), 17915333 (1) |
| shock |
23.8 |
4 |
12412622 (2), 9670921 (1), 10638671 (1) |
| cell damage |
20.7 |
14 |
9756394 (4), 9832385 (3), 10638671 (1), 10567849 (1) |
| neurodegenerative diseases |
15.8 |
5 |
17915333 (3), 17911636 (1) |
| restenosis |
14.8 |
1 |
10535908 (1) |
| asthma |
11.6 |
2 |
11448145 (1), 19845685 (1) |
Human Genome Epidemiology (HuGE) Navigator: EPRS (1 document)
Export disorders for EPRS gene to outside databases
|
Publications
for EPRS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EPRS gene, integrated from 9 sources (see all 324):
(articles sorted by number of sources associating them with EPRS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The primary structure of human glutaminyl-tRNA synthetase. A highly conserved core, amino acid repeat regions, and homologies with translation elongation factors. (PubMed id 1988429)1, 2, 3 Fett R. and Knippers R. (1991)
- Two-site phosphorylation of EPRS coordinates multimod al regulation of noncanonical translational control activity. (PubMed id 19647514)1, 2, 9 Arif A....Fox P.L. (2009)
- Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation. (PubMed id 15479637)1, 2, 9 Sampath P....Fox P.L. (2004)
- Structural analysis of multifunctional peptide motifs in human bifunctional tRNA synthetase: identification of RNA-binding residues and functional implications for tandem repeats. (PubMed id 11123902)1, 2, 9 Jeong E.-J.... Kim K.-S. (2000)
- A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis. (PubMed id 15994936)1, 2, 9 Kato T.... Nakamura Y. (2005)
- Phosphorylation of glutamyl-prolyl tRNA synthetase by cyclin-dependent kinase 5 dictates transcript-selective translational control. (PubMed id 21220307)1, 2 Arif A....Fox P.L. (2011)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Exons encoding the highly conserved part of human glutaminyl-tRNA synthetase. (PubMed id 1556743)1, 2 Kaiser E.... Knippers R. (1992)
- A component of the multisynthetase complex is a multifunctional aminoacyl-tRNA synthetase. (PubMed id 1756734)1, 2 Cerini C.... Semeriva M. (1991)
- The core region of human glutaminyl-tRNA synthetase homologies with the Escherichia coli and yeast enzymes. (PubMed id 3290852)1, 2 Thoemmes P.... Knippers R. (1988)
|
External Searches for EPRS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing EPRS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing EPRS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EPRS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for EPRS | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for EPRS gene:
Search GeneIP for patents involving EPRS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for EPRS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for EPRS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EPRS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EPRS | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for EPRS | | OriGene 3'-UTR Clone for EPRS | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EPRS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EPRS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for EPRS | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for EPRS | | OriGene Custom Protein Services for EPRS | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EPRS | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EPRS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPRS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPRS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPRS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPRS |
| |
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| | | | Search Tocris compounds for EPRS |
| |  |  |  |  | | | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPRS |
|  |  |  | | | | ThermoFisher Antibodies for EPRS |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPRS |
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