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Aliases for EPRS Gene

Aliases for EPRS Gene

  • Glutamyl-Prolyl-TRNA Synthetase 2 3
  • PARS 3 4 6
  • Cell Proliferation-Inducing Gene 32 Protein 3 4
  • Bifunctional Aminoacyl-TRNA Synthetase 3 4
  • Glutamatyl-Prolyl-TRNA Synthetase 3 4
  • Glutamate TRNA Ligase 2 3
  • Proline TRNA Ligase 2 3
  • QARS 3 4
  • QPRS 3 4
  • Bifunctional Glutamate/Proline--TRNA Ligase 3
  • Proliferation-Inducing Gene 32 Protein 3
  • Proliferation-Inducing Protein 32 3
  • Glutaminyl-TRNA Synthetase 3
  • Prolyl-TRNA Synthetase 3
  • Proline-TRNA Ligase 3
  • EC 6.1.1.15 63
  • EC 6.1.1.18 63
  • GLUPRORS 3
  • EC 6.1.1 63
  • PIG32 3
  • GLNS 4
  • EARS 3

External Ids for EPRS Gene

Previous HGNC Symbols for EPRS Gene

  • QPRS
  • QARS

Previous GeneCards Identifiers for EPRS Gene

  • GC01M218738
  • GC01M215985
  • GC01M216688
  • GC01M217198
  • GC01M216530
  • GC01M218208
  • GC01M220141
  • GC01M190816

Summaries for EPRS Gene

Entrez Gene Summary for EPRS Gene

  • Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for EPRS Gene

EPRS (Glutamyl-Prolyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with EPRS include hemorrhagic cystitis. Among its related pathways are Metabolism and Gene Expression. GO annotations related to this gene include RNA stem-loop binding and proline-tRNA ligase activity.

UniProtKB/Swiss-Prot for EPRS Gene

  • Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.

Gene Wiki entry for EPRS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPRS Gene

Genomics for EPRS Gene

Regulatory Elements for EPRS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EPRS Gene

Start:
219,968,600 bp from pter
End:
220,046,658 bp from pter
Size:
78,059 bases
Orientation:
Minus strand

Genomic View for EPRS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EPRS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPRS Gene

Proteins for EPRS Gene

  • Protein details for EPRS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07814-SYEP_HUMAN
    Recommended name:
    Bifunctional glutamate/proline--tRNA ligase
    Protein Accession:
    P07814
    Secondary Accessions:
    • A0AVA9
    • B9EGH3
    • Q05BP6
    • Q05DF8
    • Q5DSM1
    • Q5H9S5
    • Q6PD57
    • Q86X73

    Protein attributes for EPRS Gene

    Size:
    1512 amino acids
    Molecular mass:
    170591 Da
    Quaternary structure:
    • Component of the multisynthetase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthetase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA synthetases as well as three auxiliary proteins, p18, p48 and p43. Interacts with DUS2L. Component of the GAIT complex; in humans the complex assembly seems to be a two-step process in which EPRS first associates with SYNCRIP to form a pre-GAIT complex which is deficient in GAIT element binding.
    SequenceCaution:
    • Sequence=AAH15494.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH34797.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH46156.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH58921.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAS72877.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA30354.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=CAA38224.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EPRS Gene

neXtProt entry for EPRS Gene

Proteomics data for EPRS Gene at MOPED

Selected DME Specific Peptides for EPRS Gene

Post-translational modifications for EPRS Gene

  • Phosphorylated at Ser-886 by CDK5 and at Ser-999 by an unknown kinase in a IFN-gamma-dependent manner in monocytes; these sequential phosphorylations are causing release from the multisynthetase complex, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition. Phosphorylation at Ser-999 is specifically required for the interaction of GAIT complex-associated RPL13A with eIF4G.
  • Ubiquitination at Lys229, Lys435, Lys472, Lys535, Lys782, Lys861, Lys943, Lys1132, Lys1143, Lys1375, Lys1435, and Lys1503
  • Modification sites at PhosphoSitePlus

Other Protein References for EPRS Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for EPRS Gene

Gene Families for EPRS Gene

HGNC:
  • aaRS1 :Aminoacyl tRNA synthetases / Class I
  • aaRS2 :Aminoacyl tRNA synthetases / Class II

Suggested Antigen Peptide Sequences for EPRS Gene

Graphical View of Domain Structure for InterPro Entry

P07814

UniProtKB/Swiss-Prot:

SYEP_HUMAN :
  • P07814
Domain:
  • The WHEP-TRS domain is involved in RNA binding
  • Contains 3 WHEP-TRS domains.
Family:
  • In the N-terminal section; belongs to the class-I aminoacyl-tRNA synthetase family.
  • In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with EPRS: view

Function for EPRS Gene

Molecular function for EPRS Gene

GENATLAS Biochemistry: glutamyl-prolyl-tRNA synthetase
UniProtKB/Swiss-Prot CatalyticActivity: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)
UniProtKB/Swiss-Prot CatalyticActivity: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)
UniProtKB/Swiss-Prot Function: Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.

Enzyme Numbers (IUBMB) for EPRS Gene

Gene Ontology (GO) - Molecular Function for EPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0004812 aminoacyl-tRNA ligase activity --
GO:0004818 glutamate-tRNA ligase activity TAS --
GO:0004827 proline-tRNA ligase activity TAS --
GO:0005515 protein binding IPI 10913161
genes like me logo Genes that share ontologies with EPRS: view
genes like me logo Genes that share phenotypes with EPRS: view

Animal Model Products

CRISPR Products

miRNA for EPRS Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EPRS

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for EPRS Gene

Localization for EPRS Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPRS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPRS Gene COMPARTMENTS Subcellular localization image for EPRS gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for EPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 8188258
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0017101 aminoacyl-tRNA synthetase multienzyme complex IEA --
GO:0030529 ribonucleoprotein complex IDA 15479637
genes like me logo Genes that share ontologies with EPRS: view

Pathways for EPRS Gene

genes like me logo Genes that share pathways with EPRS: view

Pathways by source for EPRS Gene

Gene Ontology (GO) - Biological Process for EPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation --
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006424 glutamyl-tRNA aminoacylation IEA --
GO:0006433 prolyl-tRNA aminoacylation IEA --
GO:0006461 protein complex assembly TAS 8188258
genes like me logo Genes that share ontologies with EPRS: view

Compounds for EPRS Gene

(7) HMDB Compounds for EPRS Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Famotidine
  • Amfamox
76824-35-6
L-Glutamic acid
  • (2S)-2-Aminopentanedioate
56-86-0
L-Proline
  • (-)-(S)-Proline
147-85-3

(5) Drugbank Compounds for EPRS Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
'5'-O-(N-(L-Alanyl)-Sulfamoyl)Adenosine
target
5'-O-(N-(L-Cysteinyl)-Sulfamoyl)Adenosine
target
'5'-O-(N-(L-Prolyl)-Sulfamoyl)Adenosine
target
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target
L-Proline
  • (-)-2-Pyrrolidinecarboxylic acid
147-85-3 target

(37) Novoseek inferred chemical compound relationships for EPRS Gene

Compound -log(P) Hits PubMed IDs
5-iodo-6-amino-1,2-benzopyrone 87.3 5
3-aminobenzamide 74.5 16
adpribose 73.6 18
peroxynitrite 71.2 47
aminoacyl-trna 70.9 5
genes like me logo Genes that share compounds with EPRS: view

Transcripts for EPRS Gene

Unigene Clusters for EPRS Gene

Glutamyl-prolyl-tRNA synthetase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EPRS

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for EPRS

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EPRS Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a ·
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9: - - -
SP10: -
SP11:
SP12:
SP13:
SP14: -
SP15:
SP16: -
SP17:

ExUns: 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35a ·
SP1:
SP2:
SP3:
SP4: -
SP5: -
SP6: -
SP7:
SP8: -
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

ExUns: 35b ^ 36a · 36b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for EPRS Gene

GeneLoc Exon Structure for
EPRS
ECgene alternative splicing isoforms for
EPRS

Expression for EPRS Gene

mRNA expression in normal human tissues for EPRS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EPRS Gene

SOURCE GeneReport for Unigene cluster for EPRS Gene Hs.497788

genes like me logo Genes that share expressions with EPRS: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EPRS Gene

Orthologs for EPRS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EPRS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EPRS 35
  • 99.6 (n)
  • 99.6 (a)
EPRS 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EPRS 35
  • 90.49 (n)
  • 92.39 (a)
EPRS 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EPRS 35
  • 91.92 (n)
  • 93.44 (a)
EPRS 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eprs 35
  • 86.16 (n)
  • 89.42 (a)
Eprs 16
Eprs 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EPRS 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Eprs 35
  • 85.1 (n)
  • 87.87 (a)
chicken
(Gallus gallus)
Aves EPRS 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EPRS 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21378 35
tropical clawed frog
(Silurana tropicalis)
Amphibia eprs 35
  • 71.24 (n)
  • 76.89 (a)
Str.1851 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14111 35
zebrafish
(Danio rerio)
Actinopterygii eprs 35
  • 68.23 (n)
  • 74.15 (a)
eprs 36
  • 66 (a)
OneToOne
wufb06c03 35
fruit fly
(Drosophila melanogaster)
Insecta Aats-glupro 37
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea ears-1 36
  • 43 (a)
OneToOne
ers-2 37
  • 49 (a)
prs-1 37
  • 53 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR264W 35
  • 52.55 (n)
  • 47.94 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 38
GUS1 35
  • 54.66 (n)
  • 48.45 (a)
GUS1 36
  • 42 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A00682g 35
  • 54.61 (n)
  • 49.18 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5281 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G26710 35
  • 52.18 (n)
  • 43.9 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.4312 35
corn
(Zea mays)
Liliopsida Zm.3156 35
rice
(Oryza sativa)
Liliopsida Os.6059 35
Os01g0271200 35
  • 53.75 (n)
  • 45.18 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08894 35
  • 49.64 (n)
  • 43.95 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC17A5.15c 35
  • 53.49 (n)
  • 48.69 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14752 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11263 36
  • 55 (a)
OneToOne
Species with no ortholog for EPRS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EPRS Gene

ENSEMBL:
Gene Tree for EPRS (if available)
TreeFam:
Gene Tree for EPRS (if available)

Paralogs for EPRS Gene

Selected SIMAP similar genes for EPRS Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with EPRS: view

No data available for Paralogs for EPRS Gene

Variants for EPRS Gene

Sequence variations from dbSNP and Humsavar for EPRS Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs10987 -- 220,032,506(-) AAGAA(C/T)AGTTG reference, stop-gained
rs949866 -- 219,973,001(+) ACCCA(A/C)ATTAG intron-variant
rs953756 -- 219,973,073(+) TAACC(A/G)TAATA intron-variant
rs1061160 -- 219,981,426(-) GTACA(A/G)TCACA synonymous-codon, reference
rs1061242 -- 219,968,728(-) AGACC(A/G/T)TTTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for EPRS Gene

Variant ID Type Subtype PubMed ID
nsv832636 CNV Loss 17160897
nsv819514 CNV Loss 19587683
esv9238 CNV Gain 19470904
esv1351321 CNV Insertion 17803354
esv5550 CNV Gain 19470904
nsv4632 CNV Insertion 18451855

Relevant External Links for EPRS Gene

HapMap Linkage Disequilibrium report
EPRS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPRS Gene

Disorders for EPRS Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for EPRS Gene including...

Search for EPRS Gene in MalaCards »

(44) Novoseek inferred disease relationships for EPRS Gene

Disease -log(P) Hits PubMed IDs
inflammation 59.6 51
vascular ring 47.1 1
thrombosis 44.2 8
airways disease 36.5 4
neurodegeneration 28.5 3

Relevant External Links for EPRS

Genetic Association Database (GAD)
EPRS
Human Genome Epidemiology (HuGE) Navigator
EPRS
genes like me logo Genes that share disorders with EPRS: view

No data available for UniProtKB/Swiss-Prot for EPRS Gene

Publications for EPRS Gene

  1. Structural analysis of multifunctional peptide motifs in human bifunctional tRNA synthetase: identification of RNA-binding residues and functional implications for tandem repeats. (PMID: 11123902) Jeong E.-J. … Kim K.-S. (Biochemistry 2000) 3 4 23
  2. Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene- specific silencing of translation. (PMID: 15479637) Sampath P. … Fox P.L. (Cell 2004) 3 4 23
  3. A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis. (PMID: 15994936) Kato T. … Nakamura Y. (Cancer Res. 2005) 3 4 23
  4. Two-site phosphorylation of EPRS coordinates multimodal regulation of noncanonical translational control activity. (PMID: 19647514) Arif A. … Fox P.L. (Mol. Cell 2009) 3 4 23
  5. The primary structure of human glutaminyl-tRNA synthetase. A highly conserved core, amino acid repeat regions, and homologies with translation elongation factors. (PMID: 1988429) Fett R. … Knippers R. (J. Biol. Chem. 1991) 2 3 4

Products for EPRS Gene

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