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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EPPIN Gene

protein-coding   GIFtS: 37
GCID: GC20M044184

Epididymal Peptidase Inhibitor

(Previous names: serine protease inhibitor-like, with Kunitz and WAP domains...)
(Previous symbol: SPINLW1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Epididymal Peptidase Inhibitor1 2     WAP72 3
SPINLW11 2 3     WFDC72 3
Epididymal Protease Inhibitor1 2 3     WAP Four-Disulfide Core Domain Protein 72 3
Serine Peptidase Inhibitor-Like, With Kunitz And WAP Domains 1 (Eppin)1 2     Serine Protease Inhibitor-Like, With Kunitz And WAP Domains 1 (Eppin)1
Cancer/Testis Antigen 721 2     CT722
Cancer/Testis Antigen 712 3     dJ461P17.22
Protease Inhibitor WAP72 3     eppin2
CT712 3     Serine Protease Inhibitor-Like With Kunitz And WAP Domains 13

External Ids:    HGNC: 159321   Entrez Gene: 571192   Ensembl: ENSG000001014487   OMIM: 6090315   UniProtKB: O959253   

Export aliases for EPPIN gene to outside databases

Previous GC identifer: GC20M044176


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EPPIN Gene:
This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide
core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two
clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric
cluster. The protein can inhibit human sperm motility, and polymorphisms in this gene are associated with male
infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP
four-disulfide core domain 6) gene. (provided by RefSeq, Nov 2010)

GeneCards Summary for EPPIN Gene: 
EPPIN (epididymal peptidase inhibitor) is a protein-coding gene. Diseases associated with EPPIN include epididymitis, and infertility. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and protein binding. An important paralog of this gene is WFDC6.

UniProtKB/Swiss-Prot: EPPI_HUMAN, O95925
Function: Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the
hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the
ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility

Gene Wiki entry for EPPIN (SPINLW1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for EPPIN
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEPPIN promoter sequence
   Search SABiosciences Chromatin IP Primers for EPPIN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPPIN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

EPPIN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPPIN gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M044184:  view genomic region     (about GC identifiers)

Start:
44,165,625 bp from pter      End:
44,176,391 bp from pter
Size:
10,767 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EPPI_HUMAN, O95925 (See protein sequence)
Recommended Name: Eppin precursor  
Size: 133 amino acids; 15284 Da
Subunit: Monomer. Homodimer. Homomultimers. Interacts with SEMG1 (via 164-283 AA). Interacts with LTF. Found in a
complex with LTF, CLU, EPPIN and SEMG1
Subcellular location: Isoform 1: Secreted. Cell surface. Note=Bound to the surface of testicular and on the head
and tail of ejaculate spermatozoa
Miscellaneous: Might be used as a target for male contraception (PubMed:22699487)
Secondary accessions: A6PVD6 Q86TP9 Q96SD7 Q9HD30
Alternative splicing: 3 isoforms:  O95925-1   O95925-2   O95925-3   (Based on a readthrough transcript which may produce a EPPIN-WFDC6 fusion protein. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EPPIN: NX_O95925

Explore proteomics data for EPPIN at MOPED 

EPPIN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

EPPIN Protein Expression

REFSEQ proteins: NP_065131.1  
ENSEMBL proteins: 
 ENSP00000361746   ENSP00000387153   ENSP00000338114   ENSP00000452085  

Human Recombinant Protein Products for EPPIN: 
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Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--
GO:0009986cell surface IEA--

EPPIN for ontologies           About GeneDecksing



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Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
WFDC: WAP four-disulfide core domain containing

3 InterPro protein domains:
 IPR002223 Prot_inh_Kunz-m
 IPR008197 WAP-type_4-diS_core
 IPR020901 Prtase_inh_Kunz-CS

Graphical View of Domain Structure for InterPro Entry O95925

ProtoNet protein and cluster: O95925

2 Blocks protein domains:
IPB002223 Pancreatic trypsin inhibitor (Kunitz)
IPB008197 4-disulphide core signature


UniProtKB/Swiss-Prot: EPPI_HUMAN, O95925
Domain: The BPTI/Kunitz inhibitor domain is required for elastase inhibitory activity. BPTI/Kunitz inhibitor and
WAP domains are involved in the protein antibacterial activity
Similarity: Contains 1 BPTI/Kunitz inhibitor domain
Similarity: Contains 1 WAP domain


EPPIN for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: EPPI_HUMAN, O95925
Function: Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the
hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the
ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004867serine-type endopeptidase inhibitor activity IEA--
GO:0005515protein binding IPI15590901
GO:0030414peptidase inhibitor activity ----
     
EPPIN for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for EPPIN 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EPPIN

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EPPIN 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EPPIN 

miRNA
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Inhib. RNA
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Clone
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Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPPIN


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EPPIN

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0010466negative regulation of peptidase activity IDA18331357
GO:0042742defense response to bacterium IDA18331357

EPPIN for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EPPIN for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for EPPIN (EPPI)

3 Novoseek inferred chemical compound relationships for EPPIN gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
whey 67 4 17044815 (1), 15229136 (1), 16423450 (1)
cysteine 21.3 3 15590901 (2)
serine 4.6 6 17644992 (1), 17566290 (1)

Search CenterWatch for drugs/clinical trials and news about EPPIN / EPPI

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for EPPIN gene (2 alternative transcripts): 
NM_020398.3  NM_181502.1  

Unigene Cluster for EPPIN:

Epididymal peptidase inhibitor
Hs.121084  [show with all ESTs]
Unigene Representative Sequence: NM_020398
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000354280(uc002xou.3) ENST00000409554 ENST00000336443 ENST00000496898(uc002xov.2)
ENST00000555685
miRNA
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Search QIAGEN for miScript miRNA Assays for microRNAs that regulate EPPIN
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Inhib. RNA
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Primer
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OriGene qPCR primer pairs and template standards for EPPIN
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPPIN
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPPIN

Additional mRNA sequence: 

AF286368.1 AF286369.1 AF286370.2 AK311906.1 AL118493.1 BC003675.1 BC044829.1 BC053369.1 

6 DOTS entries:

DT.100743157  DT.107690  DT.95366079  DT.95090034  DT.100739455  DT.120812006 

24/54 AceView cDNA sequences (see all 54):

NM_181502 AF411861 AF286370 AL118493 AF286369 AI633364 AF286368 AK126022 
NM_080827 NM_020398 AI648695 AI222418 AL449631 AL449632 AA452055 AI039400 
AW449129 AI023486 BI519942 BX094264 BI828181 AI374968 BC044829 AA451856 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

EPPIN expression in normal human tissues (normalized intensities)      EPPIN embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
EPPIN Expression
About this image


EPPIN expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/4 selected tissues (see all 4) fully expand
 
 Testis (Reproductive System)    fully expand to see all 3 entries
         XY Germ Cells Testis Cord
         Seminiferous Tubules
 
 Epithelium (Respiratory System)    fully expand to see all 3 entries
         bronchial epithelia   
 
 Ovary (Reproductive System)    fully expand to see all 2 entries
         Pre-Granulosa Cells Primordial Follicle
 
 Gonad
         XY Germ Cells Testis Cord

See EPPIN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EPPIN

SOURCE GeneReport for Unigene cluster: Hs.121084

UniProtKB/Swiss-Prot: EPPI_HUMAN, O95925
Tissue specificity: In testis, expressed and secreted by Sertoli cells, appearing on the surface of testicular and
ejaculate spermatozoa. Expressed in the spermatogonia and the earliest preleptotene spermatocytes. In the
epididymis, is expressed and secreted by epithelial cells and covers the surface of epididymal spermatozoa and
ciliated epithelial cells (at protein level). Expressed specifically in epididymis and testis. Isoform 2 is
expressed only in the epididymis. Weak expression is detected in myoid cells as well as spermatogenic cells

    SABiosciences Custom PCR Arrays for EPPIN
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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPPIN

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for EPPIN gene from 3/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Eppin5 serine protease inhibitor-like, with Kunitz and WAP more   --   2 (85.21 cM) 164588343 
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 5)
Uncharacterized protein
(see all 5)
9(a)
9(a)
(see all 5)
many ↔ many
many ↔ many
(see all 5)
GL343322.1(935358-945110)
GL343322.1(968113-982172)
zebrafish
(Danio rerio)
Actinopterygii spint26
serine peptidase inhibitor, Kunitz type, 2
6(a)
possible ortholog
15(19200783-19212158)


ENSEMBL Gene Tree for EPPIN (if available)
TreeFam Gene Tree for EPPIN (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for EPPIN gene
WFDC62  WFDC82  EPPIN-WFDC62  
13 SIMAP similar genes for EPPIN using alignment to 2 protein entries:     EPPI_HUMAN (see all proteins):
SPINLW1    COL6A3    DKFZp686D23123    WFDC6    SPINT2    TFPI2
SPINT3    APP    APLP2    WFIKKN2    WFDC3    TFPI
WFDC8

EPPIN for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

2 SNPs in EPPIN are shown    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0529504
----see VAR_0529502 K T mis40--------
VAR_0246964
----see VAR_0246962 H R mis40--------

HapMap Linkage Disequilibrium report for EPPIN (44165625 - 44176391 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for EPPIN: --
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing EPPIN
DNA2.0 Custom Variant and Variant Library Synthesis for EPPIN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 609031    OMIM disorders: --

7 diseases for EPPIN:    About MalaCards
epididymitis    infertility    male infertility    azoospermia
prostate cancer    prostatitis    pancreatitis


EPPIN for disorders           About GeneDecksing

1 Novoseek inferred disease relationship for EPPIN gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
infertility 39.6 3 18466682 (1), 17345778 (1), 20158997 (1)


Export disorders for EPPIN gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for EPPIN gene, integrated from 9 sources (see all 38):
(articles sorted by number of sources associating them with EPPIN)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and sequencing of human eppin: a novel family of protease inhibitors expressed in the epididymis and testis. (PubMed id 11404006)1, 2, 3, 9 Richardson R.T.... O'Rand M.G. (2001)
  2. Association of eppin with semenogelin on human spermatozoa. (PubMed id 15590901)1, 2, 9 Wang Z....Richardson R.T. (2005)
  3. Eppin: a molecular strategy for male contraception. (PubMed id 17644992)1, 2, 9 Wang Z....Orand M.G. (2007)
  4. Antimicrobial activity of human EPPIN, an androgen-regulated, sperm-bound protein with a whey acidic protein motif. (PubMed id 15229136)1, 2, 9 Yenugu S....Hall S.H. (2004)
  5. Functional domains of the human epididymal protease inhibitor, eppin. (PubMed id 18331357)1, 2, 9 McCrudden M.T....Timson D.J. (2008)
  6. Characterization of an eppin protein complex from human semen and spermatozoa. (PubMed id 17567961)1, 2, 9 Wang Z....O'Rand M.G. (2007)
  7. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PubMed id 12206714)1, 3, 9 Clauss A.... Lundwall A. (2002)
  8. Characterization of EPPIN's semenogelin I binding Site: a contraceptive drug target. (PubMed id 22699487)1, 2 Silva E.J.... O'Rand M.G. (2012)
  9. Distribution of Eppin in mouse and human testis. (PubMed id 21461566)1, 2 Long Y....Wang X. (2011)
  10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 57119 HGNC: 15932 AceView: SPINLW1andWFDC6 Ensembl:ENSG00000101448 euGenes: HUgn57119
ECgene: EPPIN H-InvDB: EPPIN

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for EPPIN Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for EPPIN gene:
Search GeneIP for patents involving EPPIN

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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