Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EPPIN Gene

Aliases for EPPIN Gene

  • Epididymal Peptidase Inhibitor 2 3
  • Epididymal Protease Inhibitor 2 3 4
  • SPINLW1 3 4 6
  • WAP7 3 4 6
  • Serine Peptidase Inhibitor-Like, With Kunitz And WAP Domains 1 (Eppin) 2 3
  • WAP Four-Disulfide Core Domain Protein 7 3 4
  • Cancer/Testis Antigen 72 2 3
  • Cancer/Testis Antigen 71 3 4
  • Protease Inhibitor WAP7 3 4
  • WFDC7 3 4
  • CT71 3 4
  • Serine Protease Inhibitor-Like, With Kunitz And WAP Domains 1 (Eppin) 2
  • Serine Protease Inhibitor-Like With Kunitz And WAP Domains 1 4
  • DJ461P17.2 3
  • Eppin 3
  • CT72 3

External Ids for EPPIN Gene

Previous Symbols for EPPIN Gene

  • SPINLW1

Summaries for EPPIN Gene

Entrez Gene Summary for EPPIN Gene

  • This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. The protein can inhibit human sperm motility and exhibits antimicrobial activity against E. coli, and polymorphisms in this gene are associated with male infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP four-disulfide core domain 6) gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

GeneCards Summary for EPPIN Gene

EPPIN (Epididymal Peptidase Inhibitor) is a Protein Coding gene. Diseases associated with EPPIN include male infertility and infertility. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is WFDC6.

UniProtKB/Swiss-Prot for EPPIN Gene

  • Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility.

Gene Wiki entry for EPPIN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPPIN Gene

Genomics for EPPIN Gene

Genomic Location for EPPIN Gene

Start:
45,540,626 bp from pter
End:
45,547,752 bp from pter
Size:
7,127 bases
Orientation:
Minus strand

Genomic View for EPPIN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EPPIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPPIN Gene

No data available for Regulatory Elements for EPPIN Gene

Proteins for EPPIN Gene

  • Protein details for EPPIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95925-EPPI_HUMAN
    Recommended name:
    Eppin
    Protein Accession:
    O95925
    Secondary Accessions:
    • A6PVD6
    • Q86TP9
    • Q96SD7
    • Q9HD30

    Protein attributes for EPPIN Gene

    Size:
    133 amino acids
    Molecular mass:
    15284 Da
    Quaternary structure:
    • Monomer. Homodimer. Homomultimers. Interacts with SEMG1 (via 164-283 AA). Interacts with LTF. Found in a complex with LTF, CLU, EPPIN and SEMG1.
    Miscellaneous:
    • Might be used as a target for male contraception.

    Alternative splice isoforms for EPPIN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPPIN Gene

Proteomics data for EPPIN Gene at MOPED

Post-translational modifications for EPPIN Gene

No Post-translational modifications

Other Protein References for EPPIN Gene

No data available for DME Specific Peptides for EPPIN Gene

Domains for EPPIN Gene

Gene Families for EPPIN Gene

HGNC:
  • WFDC :WAP four-disulfide core domain containing

Graphical View of Domain Structure for InterPro Entry

O95925

UniProtKB/Swiss-Prot:

EPPI_HUMAN
Domain:
  • The BPTI/Kunitz inhibitor domain is required for elastase inhibitory activity. BPTI/Kunitz inhibitor and WAP domains are involved in the protein antibacterial activity.:
    • O95925
  • Contains 1 BPTI/Kunitz inhibitor domain.:
    • O95925
  • Contains 1 WAP domain.:
    • O95925
genes like me logo Genes that share domains with EPPIN: view

No data available for Suggested Antigen Peptide Sequences for EPPIN Gene

Function for EPPIN Gene

Molecular function for EPPIN Gene

UniProtKB/Swiss-Prot Function: Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility.

Gene Ontology (GO) - Molecular Function for EPPIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 15590901
GO:0030414 peptidase inhibitor activity --
genes like me logo Genes that share ontologies with EPPIN: view

miRNA for EPPIN Gene

miRTarBase miRNAs that target EPPIN

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for EPPIN Gene

Localization for EPPIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPPIN Gene

Isoform 1: Secreted. Cell surface. Note=Bound to the surface of testicular and on the head and tail of ejaculate spermatozoa.

Gene Ontology (GO) - Cellular Components for EPPIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with EPPIN: view

No data available for Subcellular locations from COMPARTMENTS for EPPIN Gene

Pathways for EPPIN Gene

SuperPathways for EPPIN Gene

No Data Available

Interacting Proteins for EPPIN Gene

Gene Ontology (GO) - Biological Process for EPPIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IDA 18331357
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0042742 defense response to bacterium IDA 18331357
genes like me logo Genes that share ontologies with EPPIN: view

No data available for Pathways by source for EPPIN Gene

Compounds for EPPIN Gene

(3) Novoseek inferred chemical compound relationships for EPPIN Gene

Compound -log(P) Hits PubMed IDs
whey 67 3
cysteine 21.3 2
serine 4.6 2
genes like me logo Genes that share compounds with EPPIN: view

Transcripts for EPPIN Gene

Unigene Clusters for EPPIN Gene

Epididymal peptidase inhibitor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EPPIN Gene

No ASD Table

Relevant External Links for EPPIN Gene

GeneLoc Exon Structure for
EPPIN
ECgene alternative splicing isoforms for
EPPIN

Expression for EPPIN Gene

mRNA expression in normal human tissues for EPPIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EPPIN Gene

This gene is overexpressed in Testis (49.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for EPPIN Gene

SOURCE GeneReport for Unigene cluster for EPPIN Gene Hs.121084

mRNA Expression by UniProt/SwissProt for EPPIN Gene

O95925-EPPI_HUMAN
Tissue specificity: In testis, expressed and secreted by Sertoli cells, appearing on the surface of testicular and ejaculate spermatozoa. Expressed in the spermatogonia and the earliest preleptotene spermatocytes. In the epididymis, is expressed and secreted by epithelial cells and covers the surface of epididymal spermatozoa and ciliated epithelial cells (at protein level). Expressed specifically in epididymis and testis. Isoform 2 is expressed only in the epididymis. Weak expression is detected in myoid cells as well as spermatogenic cells.
genes like me logo Genes that share expressions with EPPIN: view

Orthologs for EPPIN Gene

This gene was present in the common ancestor of animals.

Orthologs for EPPIN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SPINLW1 36
  • 63 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Eppin 16
Eppin 36
  • 61 (a)
OneToMany
Wfdc6a 35
  • 66.67 (n)
  • 52.17 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 31 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Wfdc6a 35
  • 66.08 (n)
  • 54.39 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3604 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R12A1.3 36
  • 18 (a)
OneToMany
Species with no ortholog for EPPIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for EPPIN Gene

ENSEMBL:
Gene Tree for EPPIN (if available)
TreeFam:
Gene Tree for EPPIN (if available)

Paralogs for EPPIN Gene

Paralogs for EPPIN Gene

Selected SIMAP similar genes for EPPIN Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with EPPIN: view

Variants for EPPIN Gene

Sequence variations from dbSNP and Humsavar for EPPIN Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
VAR_024696 -
VAR_052950 -

Relevant External Links for EPPIN Gene

HapMap Linkage Disequilibrium report
EPPIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EPPIN Gene

Disorders for EPPIN Gene

(1) Novoseek inferred disease relationships for EPPIN Gene

Disease -log(P) Hits PubMed IDs
infertility 39.6 3
genes like me logo Genes that share disorders with EPPIN: view

No data available for UniProtKB/Swiss-Prot for EPPIN Gene

Publications for EPPIN Gene

  1. Cloning and sequencing of human eppin: a novel family of protease inhibitors expressed in the epididymis and testis. (PMID: 11404006) Richardson R.T. … O'Rand M.G. (Gene 2001) 2 3 4 23
  2. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PMID: 12206714) Clauss A. … Lundwall A. (Biochem. J. 2002) 2 3 23
  3. Antimicrobial activity of human EPPIN, an androgen-regulated, sperm- bound protein with a whey acidic protein motif. (PMID: 15229136) Yenugu S. … Hall S.H. (Biol. Reprod. 2004) 3 4 23
  4. Characterization of an eppin protein complex from human semen and spermatozoa. (PMID: 17567961) Wang Z. … O'Rand M.G. (Biol. Reprod. 2007) 3 4 23
  5. Eppin: a molecular strategy for male contraception. (PMID: 17644992) Wang Z. … Orand M.G. (Soc. Reprod. Fertil. Suppl. 2007) 3 4 23

Products for EPPIN Gene

Sources for EPPIN Gene

Back to Top

Content