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Aliases for EPOP Gene

Aliases for EPOP Gene

  • Elongin BC And Polycomb Repressive Complex 2 Associated Protein 2 3
  • C17orf96 3 4 5
  • Chromosome 17 Open Reading Frame 96 2 5
  • Proline Rich 28 2 3
  • Uncharacterized Protein C17orf96 3
  • PRR28 3

External Ids for EPOP Gene

Previous HGNC Symbols for EPOP Gene

  • C17orf96

Summaries for EPOP Gene

GeneCards Summary for EPOP Gene

EPOP (Elongin BC And Polycomb Repressive Complex 2 Associated Protein) is a Protein Coding gene. An important paralog of this gene is SKIDA1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPOP Gene

Genomics for EPOP Gene

Regulatory Elements for EPOP Gene

Enhancers for EPOP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F038657 0.9 FANTOM5 ENCODE 2 +17.6 17647 1.3 MLX ARID4B DMAP1 SP5 MXD4 PPARG KAT8 SREBF1 MIER3 GLIS1 EPOP ARHGAP23 SRCIN1 GC17M038673 GC17M038636
GH17F038414 1.4 FANTOM5 Ensembl ENCODE 1.7 +259.5 259463 3.3 PKNOX1 ARNT ARID4B FEZF1 DMAP1 ZNF2 ZNF302 ZNF416 ZNF143 FOS ENSG00000266469 ENSG00000275665 LINC02079 ENSG00000275532 ENSG00000277501 GPR179 RPL19 ENSG00000276170 EPOP GC17M038417
GH17F038677 1.1 Ensembl ENCODE 0.8 -1.7 -1681 1.0 ATF1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 GATA2 ZNF143 ZNF207 MLLT6 PCGF2 CISD3 PIP4K2B PSMB3 CWC25 EPOP GC17M038684
GH17F038676 0.7 ENCODE 0.8 -0.9 -895 0.1 ZNF366 MTA2 IKZF1 JUNB ZNF24 TBX21 MLLT6 PCGF2 CISD3 PIP4K2B PSMB3 CWC25 EPOP GC17M038684
GH17F038674 1 ENCODE 0.8 +0.7 699 1.7 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 KLF13 SP3 PCGF2 CDK12 ENSG00000275665 ENSG00000266469 MED1 PIP4K2B MLLT6 CISD3 ENSG00000275532 SNORA21
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around EPOP on UCSC Golden Path with GeneCards custom track

Promoters for EPOP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001345463 921 1801 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 KLF13 SP3

Genomic Location for EPOP Gene

Chromosome:
17
Start:
38,671,703 bp from pter
End:
38,675,421 bp from pter
Size:
3,719 bases
Orientation:
Minus strand

Genomic View for EPOP Gene

Genes around EPOP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPOP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPOP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPOP Gene

Proteins for EPOP Gene

  • Protein details for EPOP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NHQ4-CQ096_HUMAN
    Recommended name:
    Uncharacterized protein C17orf96
    Protein Accession:
    A6NHQ4

    Protein attributes for EPOP Gene

    Size:
    379 amino acids
    Molecular mass:
    39322 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EPOP Gene

Post-translational modifications for EPOP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EPOP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EPOP Gene

Domains & Families for EPOP Gene

Protein Domains for EPOP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with EPOP: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for EPOP Gene

Function for EPOP Gene

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EPOP Gene

Localization for EPOP Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for EPOP Gene

Pathways & Interactions for EPOP Gene

SuperPathways for EPOP Gene

No Data Available

Interacting Proteins for EPOP Gene

Gene Ontology (GO) - Biological Process for EPOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048663 neuron fate commitment IBA --
genes like me logo Genes that share ontologies with EPOP: view

No data available for Pathways by source and SIGNOR curated interactions for EPOP Gene

Transcripts for EPOP Gene

mRNA/cDNA for EPOP Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EPOP Gene

Chromosome 17 open reading frame 96:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EPOP Gene

No ASD Table

Relevant External Links for EPOP Gene

GeneLoc Exon Structure for
EPOP
ECgene alternative splicing isoforms for
EPOP

Expression for EPOP Gene

NURSA nuclear receptor signaling pathways regulating expression of EPOP Gene:

EPOP

SOURCE GeneReport for Unigene cluster for EPOP Gene:

Hs.445574
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for EPOP Gene

Orthologs for EPOP Gene

This gene was present in the common ancestor of mammals.

Orthologs for EPOP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C17H17orf96 34
  • 98.94 (n)
dog
(Canis familiaris)
Mammalia C9H17orf96 34
  • 88.01 (n)
cow
(Bos Taurus)
Mammalia C19H17orf96 34
  • 86.6 (n)
rat
(Rattus norvegicus)
Mammalia LOC691153 34
  • 81.17 (n)
mouse
(Mus musculus)
Mammalia E130012A19Rik 34 16
  • 80.8 (n)
Species where no ortholog for EPOP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for EPOP Gene

ENSEMBL:
Gene Tree for EPOP (if available)
TreeFam:
Gene Tree for EPOP (if available)

Paralogs for EPOP Gene

Paralogs for EPOP Gene

genes like me logo Genes that share paralogs with EPOP: view

Variants for EPOP Gene

Sequence variations from dbSNP and Humsavar for EPOP Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111357541 -- 38,673,137(+) CCTTC(A/T)CCCGA utr-variant-3-prime
rs111565436 -- 38,674,206(+) CGCCG(A/G)GCCGC reference, missense
rs111725439 -- 38,674,427(+) GGCGT(A/G)GGGGA reference, synonymous-codon
rs112645800 -- 38,676,562(+) CCTCT(-/ACACACACAC)ACACA upstream-variant-2KB
rs11299743 -- 38,675,505(+) TGAAC(-/A)AAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for EPOP Gene

Variant ID Type Subtype PubMed ID
nsv1070830 CNV deletion 25765185
nsv1146669 OTHER inversion 26484159
nsv833438 CNV loss 17160897

Variation tolerance for EPOP Gene

Gene Damage Index Score: 9.54; 88.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EPOP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EPOP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPOP Gene

Disorders for EPOP Gene

Relevant External Links for EPOP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EPOP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EPOP

No disorders were found for EPOP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EPOP Gene

Publications for EPOP Gene

  1. EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem Cells. (PMID: 27863225) Beringer M. … Di Croce L. (Mol. Cell 2016) 2 3 64
  2. EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape. (PMID: 27863226) Liefke R. … Shi Y. (Mol. Cell 2016) 2 3 64
  3. Reciprocal interactions of human C10orf12 and C17orf96 with PRC2 revealed by BioTAP-XL cross-linking and affinity purification. (PMID: 24550272) Alekseyenko A.A. … Kuroda M.I. (Proc. Natl. Acad. Sci. U.S.A. 2014) 2 3 64
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for EPOP Gene

Sources for EPOP Gene

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