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EPO Gene

protein-coding   GIFtS: 65

GC07P100156
erythropoietin
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
EP 1, 2
Epoetin 3
MGC138142 2
MVCD2 2, 5
epoetin 2
erythropoietin 2
External Ids
HGNC: 34151
Entrez Gene: 20562
UniProtKB: P015883
Ensembl: ENSG000001304277
Search outside databases for aliases for EPO gene

Previous GC identifers: GC07P098853 GC07P099916 GC07P099929 GC07P099963

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for EPO:
This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed
of four alpha helical bundles. The protein is found in the plasma and regulates red cell
production by promoting erythroid differentiation and initiating hemoglobin synthesis. This
protein also has neuroprotective activity against a variety of potential brain injuries and
antiapoptotic functions in several tissue types. [provided by RefSeq]

UniProtKB/Swiss-Prot: EPO_HUMAN, P01588
Function: Erythropoietin is the principal hormone involved in the regulation of erythrocyte
differentiation and the maintenance of a physiological level of circulating erythrocyte mass

Gene Wiki entry for EPO (Erythropoietin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the EPO gene  

Entrez Gene cytogenetic band: 7q22   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q21

EPO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P100156:     (about GC identifiers)

Start:
100,156,359 bp from pter
End:
100,159,259 bp from pter
Size:
2,901 bases
Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 99,678,028-99,680,928     
RefSeq DNA sequence:
NC_000007.12  NT_007933.14  NT_079595.2  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: EPO_HUMAN, P01588 (See protein sequence)
Recommended Name: Erythropoietin precursor  
Size: 193 amino acids; 21307 Da
Subcellular location: Secreted
PDB structures from and Proteopedia :
1BUY (3D)    1CN4 (3D)    1EER (3D)    
Secondary accessions: Q2M2L6 Q549U2 Q9UDZ0 Q9UEZ5 Q9UHA0

REFSEQ proteins: NP_000790.2  

ENSEMBL proteins: 
ENSP00000252723 


Human Recombinant Proteins 
Invitrogen human recombinant proteins for EPO
Browse Purified and Recombinant Proteins at Millipore
Sigma-Aldrich Proteins and CompoZr ZFN for EPO  
R&D Systems Recombinant & Natural Proteins for EPO (Erythropoietin)
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (EPO)
Human Recombinant Proteins from Abnova (EPO)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
GO:0005615 extracellular space TAS3838366
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Antibodies for EPO: 
Browse Antibodies Central at Invitrogen
Millipore Mono- and Polyclonal Antibodies for the study of EPO
Sigma-Aldrich Antibodies for EPO
R&D Systems Antibodies for EPO (Erythropoietin)
Antibodies from Abcam (EPO), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (EPO)
Novus Biologicals Antibodies for EPO

Assays for EPO: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
R&D Systems Flow Cytometry Kits for EPO (Erythropoietin)         (see all)
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro domains/families:
 IPR012351 4_helix_cytokine_core
 IPR019767 EPO/TPO_CS
 IPR003013 Erythroptn
 IPR001323 EPO_TPO


   GeneDecks  EPO for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P01588

ProtoNet protein and cluster: P01588

1 Blocks protein family: IPB003013 Erythropoietin signature

UniProtKB/Swiss-Prot: EPO_HUMAN, P01588
Similarity: Belongs to the EPO/TPO family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (EPO)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (EPO)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000799

              Applied Biosystems Silencer® siRNAs for EPO

              Sigma-Aldrich siRNA and siRNA Panels for EPO  
                     Sigma-Aldrich shRNA Panels and shRNA for EPO  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for EPO
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000799
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000799
                                 untagged cDNA clone in CMV expression vector: NM_000799 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_000799

UniProtKB/Swiss-Prot: EPO_HUMAN, P01588
Function: Erythropoietin is the principal hormone involved in the regulation of erythrocyte
differentiation and the maintenance of a physiological level of circulating erythrocyte mass

Genatlas biochemistry entry for EPO:
erythropoietin,46kDa,expressed in liver and kidney,stimulating cellular differentiation of bone
marrow cells at an early stage,activating a voltage independent calcium channel dependent on
tyrosine phosphorylation

6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Epo):

embryogenesishematopoietic systemhomeostasis/metabolismlethality-prenatal/perinatal
liver/biliary system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005128 erythropoietin receptor binding IEA--
GO:0005179 hormone activity IEA--
GO:0005515 protein binding IPI17353931
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Invitrogen iPath™ Online BioAtlas - Pathways for EPO (Maps provided by GeneGo):
 Putative erythropoietin signaling pathway (part 2)
 Role of Akt in hypoxia induced HIF1 activation

   GeneDecks  EPO for the pathways selected above  
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3 Millipore Pathways for EPO
 G-protein signaling K-RAS regulation pathway
 Development EPO-induced Jak-STAT pathway
 Development EPO-induced MAPK pathway

   GeneDecks  EPO for the pathways selected above  
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for  EPO  (Your Favorite Gene powered by Ingenuity) 
 Hypoxia Signaling in the Cardiovascular System
 HIF1&alpha
 Erythropoietin Signaling

   GeneDecks  EPO for the pathways selected above  
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3 Kegg Pathways  (Kegg details for EPO):
 hsa04060 Cytokine-cytokine receptor interaction
 hsa04630 Jak-STAT signaling pathway
 hsa04640 Hematopoietic cell lineage

   GeneDecks  EPO for the pathways selected above  
About GeneDecksing
 Gene Network CentralTM Interacting Genes and Proteins Network for  EPO 


5/113 Interacting proteins for EPO (P015881 ENSP000002527233) via UniProtKB, MINT, and/or STRING (see all 113 )
InteractantInteraction Details
GeneCardExternal ID(s)
DOK2O604961EBI-1027362, EBI-1046024
EPORENSP000002221393STRING (score=.999)
HIF1AENSP000003380183STRING (score=.999)
JAK2ENSP000003710673STRING (score=.996)
ARNTENSP000003156373STRING (score=.99)
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5/14 Gene Ontology (GO) biological process terms (links to tree view) (see all 14 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0001666 response to hypoxia IEA--
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA--
GO:0006915 apoptosis IEA--
GO:0007165 signal transduction NAS3838366
GO:0007566 embryo implantation IEA--
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for EPO
UniProtKB/Swiss-Prot: EPO_HUMAN, P01588
Pharmaceutical: Used for the treatment of anemia. Available under the names Epogen (Amgen), Epogin
(Chugai), Epomax (Elanex), Eprex (Janssen-Cilag), NeoRecormon or Recormon (Roche), Dynepo (Shire
Pharmaceuticals) and Procrit (Ortho Biotech). Variations in the glycosylation pattern of EPO
distinguishes these products. Epogen, Epogin, Eprex and Procrit are generically known as epoetin
alfa, NeoRecormon and Recormon as epoetin beta, Dynepo as epoetin delta and Epomax as epoetin
omega. Epoetin zeta is the name used for some 'biosimilars' forms of epoetin alfa and is available
under the names Silapo (Stada) and Retacrit (Hospira). Darbepoetin alfa is a form created by 5
substitutions (Asn-57, Thr-59, Val-114, Asn-115 and Thr-117) that create 2 new N-glycosylation
sites. It has a longer circulating half-life in vivo. It is available under the name Aranesp
(Amgen). EPO is being much misused as a performance-enhancing drug in endurance athletes

10/35 Novoseek chemical compound relationships for EPO gene (see all 35 )
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
iron 89.51 2380 10850644 (10), 8671972 (9), 9590194 (7), 8350509 (7) (see all 99)
ferric gluconate 72.80 18 18216316 (5), 19260610 (2), 12778887 (1), 18578008 (1) (see all 7)
cilag 72.60 6 1415368 (1), 1361846 (1), 1948755 (1), 9156931 (1) (see all 6)
oxygen 55.21 479 9350435 (6), 9777287 (6), 7757199 (5), 18973793 (4) (see all 99)
pixy321 51.22 6 10344557 (1), 10706891 (1), 12595310 (1), 7579445 (1) (see all 5)
23-diphosphoglycerate 50.94 33 2195935 (3), 11569479 (2), 15248067 (2), 8001533 (2) (see all 14)
ferric sulfate 49.52 11 8851333 (2), 10982248 (1), 7677965 (1), 8473781 (1) (see all 8)
tyrosine 46.10 294 8068943 (5), 8276859 (5), 8639815 (4), 7535525 (4) (see all 99)
cuprophan 45.92 24 9790077 (5), 9360100 (1), 9093890 (1), 1296348 (1) (see all 5)
aluminium 45.81 25 1775251 (4), 1967718 (3), 9156931 (2), 1870750 (1) (see all 19)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (EPO)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (EPO)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000799

              Sigma-Aldrich siRNA and siRNA Panels for EPO  
                     Sigma-Aldrich shRNA Panels and shRNA for EPO  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_000799  

REFSEQ mRNAs for EPO gene: 

NM_000799.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_000799  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000799
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000799
                                 untagged cDNA clone in CMV expression vector: NM_000799 

Additional cDNA sequence: 

BC093628.1 BC111937.1 BC143225.1 S65458.1 X02157.1 

1 DOTS entry:

DT.452249 

12 AceView cDNA sequences:

BM931641 NM_000799 X02157 T29272 AI620493 BX094354 BQ185758 AI400428 
BM931504 W93118 AW951227 AA662379 

highest scoring ESTs for EPO:

AI400428 AI620493 AW951227 BM931504 BM931641 BQ185758 BX094354 T29272 W93118 X02157 

Unigene Cluster for EPO:

Erythropoietin
Hs.2303  [show with all ESTs]
Unigene Representative Sequence: X02157


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000252723  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

EPO expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for EPO

1 / 2 / 3

5 probe-sets matching EPO gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

1023_at2, 3 U95-A 1 0.88 1.00 1.00 1.00 X02158 0.20 1.00 0.72 1

207257_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000799 0.60 1.00 0.82 1

217254_s_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

207257_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

217254_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GGGTCCAAGT

SOURCE GeneReport for Unigene cluster: Hs.2303

Expression variation in blood from EXPOLDB for EPO

UniProtKB/Swiss-Prot: EPO_HUMAN, P01588
Tissue specificity: Produced by kidney or liver of adult mammals and by liver of fetal or neonatal
mammals

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for EPO gene from 5/6 species (see all 6 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
EPO1   -- erythropoietin 86.52(n)
82.45(a)
404002  NM_001006646.1  NP_001006647.1 
chimpanzee
(Pan troglodytes)
EPO1   -- erythropoietin 99.48(n)
99.48(a)
463609  XM_519268.2  XP_519268.2 
cow
(Bos taurus)
EPO1   -- erythropoietin 85.69(n)
80.1(a)
280784  NM_173909.2  NP_776334.1 
rat
(Rattus norvegicus)
Epo1   -- erythropoietin 79.69(n)
81.25(a)
24335  NM_017001.1  NP_058697.1 
mouse
(Mus musculus)
Epo1, 5 5 (78.00 cM)5
erythropoietin1, 5 80.03(n)1
79.17(a)1
138561  NM_007942.21  NP_031968.11 
 AF3120335  BC1192655  (see all 15)
About this table        Species with no ortholog for EPO

ENSEMBL Gene Tree for EPO
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/30 NCBI SNPs in EPO are shown (see all 30 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 13)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 7 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs16176401,2
A,C,F,H,O100155234(-) CCAGAT/GGAGTG 1 -- ng515Minor allele frequency- G:0.33MN EU EA WA 602
--
rs47296061,2
A,C,F,H100159726(+) TCCTTT/CACTCA 1 -- ng314Minor allele frequency- C:0.15EU EA WA 412
rs5512381,2
A,C,F,H100159464(-) TGGAGA/CCACCT 1 -- ng3110Minor allele frequency- C:0.31EA NA EU WA 818
rs5644491,2
C,F,H100159074(+) CTGGAG/TAACTT 1 -- ut3110Minor allele frequency- T:0.08NA EU EA WA 874
--
rs5762361,2
A,C100154911(+) gactaC/Taggcg 1 -- ng510--------
rs119762351,2
C100158317(+) CCAGCC/TGTGGG 1 P/L mis1 ese30--------
--
rs102496691,2
H100154982(+) tgccaT/Agttgt 1 -- ng514Minor allele frequency- A:0.00EU EA WA 388
--
rs5073921,2
A,C100157872(-) accacC/Ttcacc 1 -- int10--------
--
rs343719391,2
--100154880(+) ATCCTC/GCTGCC 1 -- ng510--------
--
rs69770671,2
--100154581(+) gcgggC/Ttgctg 1 -- ng510--------
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HapMap Linkage Disequilibrium images for EPO (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 133170   disorders: 612623  

UniProtKB/Swiss-Prot: EPO_HUMAN, P01588

  • Genetic variation in EPO is associated with susceptbility to microvascular complications
    of diabetes type 2 (MVCD2) [MIM:612623]; also called susceptibility to proliferative diabetic
    retinopathy (PDR) or susceptbility to diabetic end-stage renal disease (ESRD). Significant
    morbidity and mortality among patients with diabetes mellitus result largely from a greatly
    increased incidence of microvascular complications. PDR and ESRD are two of the most common and
    severe microvascular complications of diabetes. A high concordance exists in the development of
    PDR and ESRD in diabetic patients, as well as strong familial aggregation of these complications,
    suggesting a common underlying genetic mechanism. EPO is a potent angiogenic factor observed in
    the diabetic human and mouse eye
  • 10/95 Novoseek disease relationships for EPO gene (see all 95 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    anemia 96.86 5770 7557862 (7), 10827238 (7), 12713065 (7), 1421381 (6) (see all 99)
    erythrocytosis 89.56 249 14564105 (7), 15712191 (5), 15477203 (4), 7518732 (4) (see all 99)
    renal failure chronic 89.17 1008 1339766 (4), 8552143 (4), 10850644 (3), 2220877 (3) (see all 99)
    iron deficiency 89.10 290 12647284 (4), 15784734 (4), 9352960 (3), 8524494 (3) (see all 99)
    polycythemia 85.26 189 16231451 (4), 12393546 (4), 15217714 (3), 16769575 (3) (see all 99)
    red cell aplasia 82.65 109 15172775 (4), 16449549 (3), 8596164 (2), 8488547 (2) (see all 77)
    anemia severe 82.56 97 15792921 (2), 12234311 (2), 8938689 (2), 7933664 (2) (see all 76)
    polycythemia vera 80.49 67 9475763 (4), 17980427 (2), 9731054 (2), 9292543 (2) (see all 44)
    myelodysplastic syndromes 80.17 277 1961041 (3), 7505147 (3), 8398823 (2), 8411647 (2) (see all 99)
    renal disease 79.10 463 16099877 (4), 15498082 (3), 16889570 (3), 15792912 (3) (see all 99)
    About this table

    Human Gene Mutation Database: EPO
    Human Genome Epidemiology Navigator: EPO (39 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    100/3497 PubMed articles for EPO gene (see all 3497 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Search String
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 2056 HGNC: 3415 AceView: EPO Ensembl:ENSG00000130427 euGenes: HUgn2056
    ECgene: EPO H-InvDB: EPO
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for EPO Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine source book: Erythropoietinhttp://www.rndsystems.com/molecule_detail.aspx?m=1405
    Wikipedia http://en.wikipedia.org/wiki/Erythropoietin
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for EPO:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for EPO-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for EPO Antibodies for EPO
     Explore super-pooled esiRNAs Proteins for EPO
     Lentivirus-delivered shRNAs for EPO Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for EPO

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