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Aliases & Descriptions for EPO
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EP 1, 2 | | Epoetin 3 | | MGC138142 2 | | MVCD2 2, 5 | | epoetin 2 | | erythropoietin 2 |
| | |
| | Search outside databases for aliases for EPO genePrevious GC identifers: GC07P098853 GC07P099916 GC07P099929 GC07P099963 |
Summaries for EPO(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for EPO: This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq] UniProtKB/Swiss-Prot: EPO_HUMAN, P01588Function: Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte massGene Wiki entry for EPO (Erythropoietin) |
Genomic Location for EPO
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the EPO gene 
Entrez Gene cytogenetic band: 7q22 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q21EPO Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P100156:
(about GC identifiers)
Start:
|
100,156,359 bp from pter |
End:
|
100,159,259 bp from pter |
Size:
|
2,901 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 99,678,028-99,680,928 |
RefSeq DNA sequence:- NC_000007.12 NT_007933.14 NT_079595.2
| Proteins for EPO
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: EPO_HUMAN, P01588 (See
protein sequence)Recommended Name: Erythropoietin precursor Size: 193 amino acids; 21307 Da
Subcellular location: Secreted
PDB structures from and Proteopedia :1BUY (3D)
 1CN4 (3D)
 1EER (3D)
 
Secondary accessions: Q2M2L6 Q549U2 Q9UDZ0 Q9UEZ5 Q9UHA0REFSEQ proteins: NP_000790.2
ENSEMBL proteins: ENSP00000252723
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for EPO: Assays for EPO: | Protein
Domains/ Families for EPO(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P01588
ProtoNet protein and cluster: P01588 1 Blocks protein family: IPB003013 Erythropoietin signature
UniProtKB/Swiss-Prot: EPO_HUMAN, P01588Similarity: Belongs to the EPO/TPO family | Gene Function for EPO
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000799
Applied Biosystems Silencer® siRNAs for EPO
Sigma-Aldrich siRNA and siRNA Panels for EPO  Sigma-Aldrich shRNA Panels and shRNA for EPO  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000799                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000799                                  untagged cDNA clone in CMV expression vector: NM_000799 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_000799
UniProtKB/Swiss-Prot: EPO_HUMAN, P01588Function: Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte massGenatlas biochemistry entry for EPO:erythropoietin,46kDa,expressed in liver and kidney,stimulating cellular differentiation of bone marrow cells at an early stage,activating a voltage independent calcium channel dependent on tyrosine phosphorylation6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Epo):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for EPO
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
3 Sigma-Aldrich "Your Favorite Gene" Pathways for EPO (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for EPO 
5/113 Interacting proteins for EPO (P015881 ENSP000002527233) via UniProtKB, MINT, and/or STRING (see all 113
)About this table
5/14 Gene Ontology (GO) biological process terms (links to tree view) (see all 14
): About this table
|
Drugs & Compounds for EPO(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for EPO UniProtKB/Swiss-Prot: EPO_HUMAN, P01588Pharmaceutical: Used for the treatment of anemia. Available under the names Epogen (Amgen), Epogin (Chugai), Epomax (Elanex), Eprex (Janssen-Cilag), NeoRecormon or Recormon (Roche), Dynepo (Shire Pharmaceuticals) and Procrit (Ortho Biotech). Variations in the glycosylation pattern of EPO distinguishes these products. Epogen, Epogin, Eprex and Procrit are generically known as epoetin alfa, NeoRecormon and Recormon as epoetin beta, Dynepo as epoetin delta and Epomax as epoetin omega. Epoetin zeta is the name used for some 'biosimilars' forms of epoetin alfa and is available under the names Silapo (Stada) and Retacrit (Hospira). Darbepoetin alfa is a form created by 5 substitutions (Asn-57, Thr-59, Val-114, Asn-115 and Thr-117) that create 2 new N-glycosylation sites. It has a longer circulating half-life in vivo. It is available under the name Aranesp (Amgen). EPO is being much misused as a performance-enhancing drug in endurance athletes 10/35 Novoseek chemical compound relationships for EPO gene (see all 35
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| iron |
89.51 |
2380 |
10850644 (10), 8671972 (9), 9590194 (7), 8350509 (7) (see all 99) |
| ferric gluconate |
72.80 |
18 |
18216316 (5), 19260610 (2), 12778887 (1), 18578008 (1) (see all 7) |
| cilag |
72.60 |
6 |
1415368 (1), 1361846 (1), 1948755 (1), 9156931 (1) (see all 6) |
| oxygen |
55.21 |
479 |
9350435 (6), 9777287 (6), 7757199 (5), 18973793 (4) (see all 99) |
| pixy321 |
51.22 |
6 |
10344557 (1), 10706891 (1), 12595310 (1), 7579445 (1) (see all 5) |
| 23-diphosphoglycerate |
50.94 |
33 |
2195935 (3), 11569479 (2), 15248067 (2), 8001533 (2) (see all 14) |
| ferric sulfate |
49.52 |
11 |
8851333 (2), 10982248 (1), 7677965 (1), 8473781 (1) (see all 8) |
| tyrosine |
46.10 |
294 |
8068943 (5), 8276859 (5), 8639815 (4), 7535525 (4) (see all 99) |
| cuprophan |
45.92 |
24 |
9790077 (5), 9360100 (1), 9093890 (1), 1296348 (1) (see all 5) |
| aluminium |
45.81 |
25 |
1775251 (4), 1967718 (3), 9156931 (2), 1870750 (1) (see all 19) |
About this table
|
Transcripts for EPO(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000799
Sigma-Aldrich siRNA and siRNA Panels for EPO  Sigma-Aldrich shRNA Panels and shRNA for EPO  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_000799 REFSEQ mRNAs for EPO gene: NM_000799.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_000799               OriGene GFP tagged cDNA clone in CMV expression vector: NM_000799                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000799                                  untagged cDNA clone in CMV expression vector: NM_000799  Additional cDNA sequence: BC093628.1 BC111937.1 BC143225.1 S65458.1 X02157.1 1 DOTS entry: DT.452249 12 AceView cDNA sequences:BM931641 NM_000799 X02157 T29272 AI620493 BX094354 BQ185758 AI400428 BM931504 W93118 AW951227 AA662379
highest scoring ESTs for EPO:AI400428 AI620493 AW951227 BM931504 BM931641 BQ185758 BX094354 T29272 W93118 X02157 Unigene Cluster for EPO: Erythropoietin Hs.2303 [show with all ESTs]Unigene Representative Sequence: X02157
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000252723
|
Expression for EPO
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| EPO expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for EPO
1 / 2 / 3 5 probe-sets matching EPO gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGGTCCAAGT
SOURCE GeneReport for Unigene cluster: Hs.2303
Expression variation in blood from EXPOLDB for EPO UniProtKB/Swiss-Prot: EPO_HUMAN, P01588Tissue specificity: Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals |
Orthologs for EPO
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for EPO gene from 5/6 species (see all 6
)
About this table Species with no ortholog for EPO
ENSEMBL Gene Tree for EPO | Paralogs for EPO(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for EPO(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for EPO (up to first 250kb)
|
Disorders & Mutations for EPO
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 133170 disorders: 612623 UniProtKB/Swiss-Prot: EPO_HUMAN, P01588
Genetic variation in EPO is associated with susceptbility to microvascular complications of diabetes type 2 (MVCD2) [MIM:612623]; also called susceptibility to proliferative diabetic retinopathy (PDR) or susceptbility to diabetic end-stage renal disease (ESRD). Significant morbidity and mortality among patients with diabetes mellitus result largely from a greatly increased incidence of microvascular complications. PDR and ESRD are two of the most common and severe microvascular complications of diabetes. A high concordance exists in the development of PDR and ESRD in diabetic patients, as well as strong familial aggregation of these complications, suggesting a common underlying genetic mechanism. EPO is a potent angiogenic factor observed in the diabetic human and mouse eye10/95 Novoseek disease relationships for EPO gene (see all 95
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| anemia |
96.86 |
5770 |
7557862 (7), 10827238 (7), 12713065 (7), 1421381 (6) (see all 99) |
| erythrocytosis |
89.56 |
249 |
14564105 (7), 15712191 (5), 15477203 (4), 7518732 (4) (see all 99) |
| renal failure chronic |
89.17 |
1008 |
1339766 (4), 8552143 (4), 10850644 (3), 2220877 (3) (see all 99) |
| iron deficiency |
89.10 |
290 |
12647284 (4), 15784734 (4), 9352960 (3), 8524494 (3) (see all 99) |
| polycythemia |
85.26 |
189 |
16231451 (4), 12393546 (4), 15217714 (3), 16769575 (3) (see all 99) |
| red cell aplasia |
82.65 |
109 |
15172775 (4), 16449549 (3), 8596164 (2), 8488547 (2) (see all 77) |
| anemia severe |
82.56 |
97 |
15792921 (2), 12234311 (2), 8938689 (2), 7933664 (2) (see all 76) |
| polycythemia vera |
80.49 |
67 |
9475763 (4), 17980427 (2), 9731054 (2), 9292543 (2) (see all 44) |
| myelodysplastic syndromes |
80.17 |
277 |
1961041 (3), 7505147 (3), 8398823 (2), 8411647 (2) (see all 99) |
| renal disease |
79.10 |
463 |
16099877 (4), 15498082 (3), 16889570 (3), 15792912 (3) (see all 99) |
About this table
Human Gene Mutation Database: EPO Human Genome Epidemiology Navigator: EPO (39 documents)
|
Medical News for EPO(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications for EPO (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 100/3497 PubMed articles for EPO gene (see all 3497
):- Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PubMed id 9799793)2, 3, 4 Glockner G....Rosenthal A. (1998)
- Isolation and characterization of genomic and cDNA clones of human erythropoietin. (PubMed id 3838366)2, 3, 4 Jacobs K....Fritsch E.F. (1985)
- Gene expression of mutant erythropoietin in hepatocellular carcinoma. (PubMed id 8396923)1, 3, 4 Funakoshi A.... Shimizu S. (1993)
- Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications. (PubMed id 18458324)3, 4 Tong Z....Zhang K. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)3, 4 Hillier L.W.... Wilson R.K. (2003)
- Efficiency of signalling through cytokine receptors depends critically on receptor orientation. (PubMed id 9774108)3, 4 Syed R.S.... Stroud R.M. (1998)
- Structures and functional roles of the sugar chains of human erythropoietins. (PubMed id 1820196)3, 4 Takeuchi M. and Kobata A. (1991)
- Comparative study of the asparagine-linked sugar chains of human erythropoietins purified from urine and the culture medium of recombinant Chinese hamster ovary cells. (PubMed id 3346214)3, 4 Takeuchi M....Kobata A. (1988)
- Site-specific glycosylation of human recombinant erythropoietin: analysis of glycopeptides or peptides at each glycosylation site by fast atom bombardment mass spectrometry. (PubMed id 3219367)3, 4 Sasaki H.... Fukuda M. (1988)
- Structural characterization of human erythropoietin. (PubMed id 3949763)3, 4 Lai P.H.... Goldwasser E. (1986)
- Cloning and expression of the human erythropoietin gene. (PubMed id 3865178)3, 4 Lin F.-K....Goldwasser E. (1985)
- Isolation of human erythropoietin with monoclonal antibodies. (PubMed id 6698989)3, 4 Yanagawa S....Goto M. (1984)
- Cellular trafficking and degradation of erythropoietin and novel erythropoiesis stimulating protein (NESP). (PubMed id 16286456)1, 3 Gross A.W. and Lodish H.F. (2006)
- Erythropoietin and erythropoietin receptor expression in normal and disturbed pregnancy. (PubMed id 18479804)1, 3 Toth B....Jeschke U. (2008)
- A "classical" homodimeric erythropoietin receptor is essential for the antiapoptotic effects of erythropoietin on differentiated neuroblastoma SH-SY5Y and pheochromocytoma PC-12 cells. (PubMed id 17045782)1, 3 Um M....Lodish H.F. (2007)
- Functional erythropoietin autocrine loop in melanoma. (PubMed id 15743794)1, 3 Kumar S.M....Xu X. (2005)
- [Relationship between tumor necrosis factor alpha, interleukin-6 and erythropoietin in children's with chronic anemia and influence of recombinant human tumor necrosis factor alpha on erythropoietin gene expression] (PubMed id 14990112)1, 3 Zhai X.W....Lu F.J. (2004)
- Prognostic significance of erythropoietin expression in human endometrial carcinoma. (PubMed id 15160341)1, 3 Acs G....Verma A. (2004)
- Relation of erythropoietin and erythropoietin receptor expression to hypoxia and anemia in head and neck squamous cell carcinoma. (PubMed id 16278379)1, 3 Winter S.C....Harris A.L. (2005)
- Expression of erythropoietin and erythropoietin receptor in non-small cell lung carcinomas. (PubMed id 15709164)1, 3 Dagnon K....Callard P. (2005)
- Expression of erythropoietin and erythropoietin receptor in cervical cancer and relationship to survival, hypoxia, and apoptosis. (PubMed id 17145806)1, 3 Leo C....Hockel M. (2006)
- Expression of erythropoietin and its receptor in neuroblastomas. (PubMed id 17647284)1, 3 Sartelet H....Vassal G. (2007)
- Erythropoietin in thyroid cancer. (PubMed id 16699298)1, 3 Yates C.M....Francis G.L. (2006)
- Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia, and oligodendrocytes grown in culture. (PubMed id 11305874)1, 3 Nagai A....Kim S.U. (2001)
- Characterization of erythropoietin receptor and erythropoietin expression and function in human ovarian cancer cells. (PubMed id 17893874)1, 3 Jeong J.Y....Sytkowski A.J. (2008)
- Erythropoietin and erythropoietin receptor expression in human prostate cancer. (PubMed id 15467711)1, 3 Arcasoy M.O....Haroon Z.A. (2005)
- The distinct erythropoietin functions that promote cell survival and proliferation are affected by aluminum exposure through mechanisms involving erythropoietin receptor. (PubMed id 15777837)1, 3 Vittori D....Nesse A. (2005)
- Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma. (PubMed id 15856028)1, 3 Lai S.Y....Grandis J.R. (2005)
- Differential expression of erythropoietin and its receptor in von hippel-lindau-associated and multiple endocrine neoplasia type 2-associated pheochromocytomas. (PubMed id 15769989)1, 3 Vogel T.W....Zhuang Z. (2005)
- Stem cell factor enhances erythropoietin-mediated transactivation of signal transducer and activator of transcription 5 (STAT5) via the PKA/CREB pathway. (PubMed id 12829027)1, 3 Boer A.K....Vellenga E. (2003)
- Expression of erythropoietin and erythropoietin receptor in peritoneal endometriosis. (PubMed id 12525458)1, 3 Matsuzaki S....Okamura K. (2003)
- Evaluation of tumor necrosis factor-alpha and erythropoietin serum levels in B-cell chronic lymphocytic leukemia patients with anemia. (PubMed id 12187026)1, 3 Capalbo S....Liso V. (2002)
- Erythropoietin and erythropoietin receptor expression in human endometrium throughout the menstrual cycle. (PubMed id 11994541)1, 3 Yokomizo R....Okamura K. (2002)
- Interaction between the glucocorticoid and erythropoietin receptors in human erythroid cells. (PubMed id 19375647)1, 3 Stellacci E....Migliaccio A.R. (2009)
- Expression of erythropoietin and its receptor in the human retina: a comparative study of diabetic and nondiabetic subjects. (PubMed id 18332162)1, 3 Garcia-Ramirez M....Simo R. (2008)
- Does erythropoietin have a dark side? Epo signaling and cancer cells. (PubMed id 17636183)1, 3 Sytkowski A.J. (2007)
- Human hair follicles are an extrarenal source and a nonhematopoietic target of erythropoietin. (PubMed id 17540710)1, 3 Bodo E....Paus R. (2007)
- Coexpression of erythropoietin and erythropoietin receptor in von Hippel-Lindau disease-associated renal cysts and renal cell carcinoma. (PubMed id 15709172)1, 3 Lee Y.S....Zhuang Z. (2005)
- Erythropoietin and the erythropoietin receptor are expressed by papillary thyroid carcinoma from children and adolescents. Expression of erythropoietin receptor might be a favorable prognostic indicator. (PubMed id 14584755)1, 3 Eccles T.G....Francis G.L. (2003)
- Recombinant human erythropoietin administration protects cortical neurons from traumatic brain injury in rats. (PubMed id 18093155)1, 3 Liao Z.B....He Z.H. (2008)
- Increased levels of erythropoietin in nipple aspirate fluid and in ductal cells from breast cancer patients. (PubMed id 18219110)1, 3 Mannello F....Tonti G.A. (2008)
- Induction of signalling in non-erythroid cells by pharmacological levels of erythropoietin. (PubMed id 16909043)1, 3 Dunlop E.A....Lappin T.R. (2006)
- Association between nucleated red blood cells in blood and the levels of erythropoietin, interleukin 3, interleukin 6, and interleukin 12p70. (PubMed id 15988318)1, 3 Stachon A....Krieg M. (2005)
- Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression. (PubMed id 15142852)1, 3 Fandrey J. (2004)
- Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells. (PubMed id 15205261)1, 3 Beleslin-Cokic B.B....Noguchi C.T. (2004)
- Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progression. (PubMed id 12759237)1, 3 Acs G....Verma A. (2003)
- Shared and unique determinants of the erythropoietin (EPO) receptor are important for binding EPO and EPO mimetic peptide. (PubMed id 10318834)1, 3 Middleton S.A....Jolliffe L.K. (1999)
- Amniotic fluid S100B protein and erythropoietin in pregnancies at risk for fetal hypoxia. (PubMed id 19042077)1, 3 Loukovaara M....Andersson S. (2009)
- Erythropoietin and erythropoietin receptor expression in head and neck cancer: relationship to tumor hypoxia. (PubMed id 15671524)1, 3 Arcasoy M.O....Raleigh J.A. (2005)
- Brain and cancer: the protective role of erythropoietin. (PubMed id 15389732)1, 3 Buemi M....Grasso G. (2005)
- Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene. (PubMed id 15347669)1, 3 Wang F....Hankinson O. (2004)
- Does angiotensin II modulate erythropoietin production in HepG2 cells? (PubMed id 15627795)1, 3 Benohr P....Gleiter C.H. (2004)
- From erythropoietin to oxygen: hypoxia-inducible factor hydroxylases and the hypoxia signal pathway. (PubMed id 12207089)1, 3 Ratcliffe P.J. (2002)
- Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells. (PubMed id 12239177)1, 3 Stolze I....Fandrey J. (2002)
- Erythropoietin production by a hepatic adenoma in a patient with severe erythrocytosis. (PubMed id 19339771)1, 3 Vik A....Hansen J.B. (2009)
- Non-erythroid activities of erythropoietin: Functional effects on murine dendritic cells. (PubMed id 19027957)1, 3 Lifshitz L....Neumann D. (2009)
- Antibody-based enzyme-linked lectin assay (ABELLA) for the sialylated recombinant human erythropoietin present in culture supernatant. (PubMed id 18722069)1, 3 Kim H.J....Kim H.J. (2008)
- Acute and chronic exposure to hypoxia alters ventilatory pattern but not minute ventilation of mice overexpressing erythropoietin. (PubMed id 17652365)1, 3 Soliz J....Gassmann M. (2007)
- Human telomerase is regulated by erythropoietin and transforming growth factor-beta in human erythroid progenitor cells. (PubMed id 17713555)1, 3 Prade-Houdellier N....Beyne-Rauzy O. (2007)
- Dynamic control of oligosaccharide modification in the mammary gland: linking recombinant human erythropoietin functional analysis of transgenic mouse milk-derived hEPO. (PubMed id 16475009)1, 3 Kwon D.N....Kim J.H. (2006)
- Erythropoietin production: Molecular mechanisms of the antagonistic actions of cyclic adenosine monophosphate and interleukin-1. (PubMed id 16684536)1, 3 Batmunkh C....Hellwig-Burgel T. (2006)
- Vascular endothelial growth factor and its soluble receptor, Flt-1, are not correlated to erythropoietin in diabetics with normal or reduced renal function. (PubMed id 15705187)1, 3 Lenz T....Gossmann J. (2005)
- Association between erythropoietin in cord blood of twins and size at birth: does it relate to gestational factors or to factors during labor or delivery? (PubMed id 15718359)1, 3 Morley R....Carlin J.B. (2005)
- Erythropoietin signaling promotes invasiveness of human head and neck squamous cell carcinoma. (PubMed id 15967106)1, 3 Mohyeldin A....Verma A. (2005)
- Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells. (PubMed id 15240563)1, 3 Warnecke C....Eckardt K.U. (2004)
- Erythropoietin protects cerebrocortical neurons from HIV-1/gp120-induced damage. (PubMed id 15073510)1, 3 Digicaylioglu M....Lipton S.A. (2004)
- Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis. (PubMed id 12975460)1, 3 Villa P....Ghezzi P. (2003)
- The signaling pathways of erythropoietin and interferon-gamma differ in preventing the apoptosis of mature erythroid progenitor cells. (PubMed id 14704034)1, 3 Paiboonsukwong K....Muta K. (2003)
- NF-kappaB plays a key role in hypoxia-inducible factor-1-regulated erythropoietin gene expression. (PubMed id 12482504)1, 3 Figueroa Y.G....Beckman B.S. (2002)
- Glycosylation of erythropoietin affects receptor binding kinetics: role of electrostatic interactions. (PubMed id 12463751)1, 3 Darling R.J....Beals J.M. (2002)
- Influence of controlled hypoxia and radical scavenging agents on erythropoietin and malondialdehyde concentrations in humans. (PubMed id 11906322)1, 3 Freudenthaler S.M....Gleiter C.H. (2002)
- Erythropoietin response to hypoxia in patients with diabetic autonomic neuropathy and non-diabetic chronic renal failure. (PubMed id 11869305)1, 3 Bosman D.R....Watkins P.J. (2002)
- Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades. (PubMed id 11493922)1, 3 Digicaylioglu M. and Lipton S.A. (2001)
- Insulin-like growth factor-I augments erythropoietin-induced proliferation through enhanced tyrosine phosphorylation of STAT5. (PubMed id 9722506)1, 3 Okajima Y....Matsuzawa Y. (1998)
- TRPC3 activation by erythropoietin is modulated by TRPC6. (PubMed id 19074769)3 Hirschler-Laszkiewicz I....Miller B.A. (2009)
- Elevated erythropoietin mRNA and protein concentrations in the developing human eye. (PubMed id 18356745)3 Patel S....Ohls R.K. (2008)
- Decreased DMT1 and increased ferroportin 1 expression is the mechanisms of reduced iron retention in macrophages by erythropoietin in rats. (PubMed id 18189270)3 Kong W.N....Chang Y.Z. (2008)
- Erythropoietin promotes hepatic regeneration after extended liver resection in rats. (PubMed id 18086112)3 Schmeding M....Neumann U.P. (2008)
- Erythropoietin treatment of human ovarian cancer cells results in enhanced signaling and a paclitaxel-resistant phenotype. (PubMed id 17893875)3 Solar P....Sytkowski A.J. (2008)
- Erythropoietin effects on dendritic cells: potential mediators in its function as an immunomodulator? (PubMed id 18922618)3 Prutchi Sagiv S....Neumann D. (2008)
- Essential role for Stat5 in the neurotrophic but not in the neuroprotective effect of erythropoietin. (PubMed id 18259195)3 Byts N....Siren A.L. (2008)
- Erythropoietin promotes axonal growth in a model of neuronal polarization. (PubMed id 18586515)3 Ransome M.I. and Turnley A.M. (2008)
- Novel red cell indices indicating reduced availability of iron are associated with high erythropoietin concentration and low ph level in the venous cord blood of newborns. (PubMed id 18414140)3 Ervasti M....Punnonen K. (2008)
- TRPC3 is the erythropoietin-regulated calcium channel in human erythroid cells. (PubMed id 18276585)3 Tong Q....Miller B.A. (2008)
- A pilot study on cord blood levels of erythropoietin and its relationship to periventricular leukomalacia in preterm infants. (PubMed id 18160550)3 Okumura A....Watanabe K. (2008)
- Production of human erythropoietin by chimeric chickens. (PubMed id 18201556)3 Kodama D....Iijima S. (2008)
- Inverse relationship between serum erythropoietin and blood lead concentrations in Kathmandu tricycle taxi drivers. (PubMed id 16838166)3 Sakata S....Mori I. (2007)
- Is erythropoietin gene a modifier factor in amyotrophic lateral sclerosis? (PubMed id 17888545)3 Ghezzi S....Comi G.P. (2007)
- Erythropoietin regulations in humans under different environmental and experimental conditions. (PubMed id 17467346)3 Gunga H.C....Schobersberger W. (2007)
- Erythropoietin inhibits basal and stimulated corticotropin-releasing hormone release from the rat hypothalamus via a nontranscriptional mechanism. (PubMed id 17615151)3 Tringali G....Navarra P. (2007)
- Neuroprotective potential of erythropoietin and darbepoetin alfa in an experimental model of sciatic nerve injury. Laboratory investigation. (PubMed id 18074690)3 Grasso G....Iacopino D.G. (2007)
- Enhanced erythro-phagocytosis in polycythemic mice overexpressing erythropoietin. (PubMed id 17395782)3 Bogdanova A....Vogel J. (2007)
- Novel role of erythropoietin in proliferative diabetic retinopathy. (PubMed id 17481772)3 Takagi H....Murakami T. (2007)
- Erythropoietin decreases renal fibrosis in mice with ureteral obstruction: role of inhibiting TGF-beta-induced epithelial-to-mesenchymal transition. (PubMed id 17389738)3 Park S.H....Kim Y.L. (2007)
- Suggestive evidence of erythropoietin level abnormality in patients with sporadic and familial cases of the restless legs syndrome. (PubMed id 17984928)3 Kemlink D....Benakova H. (2007)
- Erythropoietin protects the intestine against ischemia/ reperfusion injury in rats. (PubMed id 17873970)3 Guneli E....Gokmen N. (2007)
- Erythropoietin enhances angiogenesis in an experimental cyclosporine A-induced nephrotoxicity model in the rat. (PubMed id 17645631)3 Efthimiadou A....Nikolettos N.K. (2007)
- Erythropoietin enhances hippocampal response during memory retrieval in humans. (PubMed id 17360900)3 Miskowiak K....Harmer C.J. (2007)
- Essential role of endothelial nitric oxide synthase in vascular effects of erythropoietin. (PubMed id 17372034)3 d'Uscio L.V....Katusic Z.S. (2007)
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