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EPO Gene

protein-coding GIFtS: 65

GC07P100156

erythropoietin
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EP ^¹, ²
Epoetin ^³
MGC138142 ^²
MVCD2 ^², ⁵
epoetin ^²
erythropoietin ^²

External Ids
HGNC: 3415¹
Entrez Gene: 2056²
UniProtKB: P01588³
Ensembl: ENSG00000130427⁷

Search outside databases for aliases for EPO gene

Previous GC identifers: GC07P098853 GC07P099916 GC07P099929 GC07P099963

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for EPO:

This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed

of four alpha helical bundles. The protein is found in the plasma and regulates red cell

production by promoting erythroid differentiation and initiating hemoglobin synthesis. This

protein also has neuroprotective activity against a variety of potential brain injuries and

antiapoptotic functions in several tissue types. [provided by RefSeq]

UniProtKB/Swiss-Prot: EPO_HUMAN, P01588

Function: Erythropoietin is the principal hormone involved in the regulation of erythrocyte

differentiation and the maintenance of a physiological level of circulating erythrocyte mass

Gene Wiki entry for EPO (Erythropoietin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the EPO gene

Entrez Gene cytogenetic band: 7q22 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q21

EPO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P100156: (about GC identifiers)

Start:	100,156,359 bp from pter
End:	100,159,259 bp from pter
Size:	2,901 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 99,678,028-99,680,928

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079595.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: EPO_HUMAN, P01588 (See protein sequence)

Recommended Name: Erythropoietin precursor

Size: 193 amino acids; 21307 Da

Subcellular location: Secreted

PDB structures from and Proteopedia :

1BUY (3D)

1CN4 (3D)

1EER (3D)

Secondary accessions: Q2M2L6 Q549U2 Q9UDZ0 Q9UEZ5 Q9UHA0

REFSEQ proteins: NP_000790.2

ENSEMBL proteins:

ENSP00000252723

Human Recombinant Proteins

	Invitrogen human recombinant proteins for EPO
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins and CompoZr ZFN for EPO
	R&D Systems Recombinant & Natural Proteins for EPO (Erythropoietin)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (EPO)
	Human Recombinant Proteins from Abnova (EPO)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	TAS	3838366

About this table

Antibodies for EPO:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of EPO
	Sigma-Aldrich Antibodies for EPO
	R&D Systems Antibodies for EPO (Erythropoietin)
	Antibodies from Abcam (EPO), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (EPO)
	Novus Biologicals Antibodies for EPO

Assays for EPO:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems Flow Cytometry Kits for EPO (Erythropoietin) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P01588

ProtoNet protein and cluster: P01588

1 Blocks protein family: IPB003013 Erythropoietin signature

UniProtKB/Swiss-Prot: EPO_HUMAN, P01588

Similarity: Belongs to the EPO/TPO family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EPO)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EPO)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000799

Applied Biosystems Silencer® siRNAs for EPO

Sigma-Aldrich siRNA and siRNA Panels for EPO

Sigma-Aldrich shRNA Panels and shRNA for EPO

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for EPO
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000799
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000799
untagged cDNA clone in CMV expression vector: NM_000799

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000799

UniProtKB/Swiss-Prot: EPO_HUMAN, P01588

Function: Erythropoietin is the principal hormone involved in the regulation of erythrocyte

differentiation and the maintenance of a physiological level of circulating erythrocyte mass

Genatlas biochemistry entry for EPO:

erythropoietin,46kDa,expressed in liver and kidney,stimulating cellular differentiation of bone

marrow cells at an early stage,activating a voltage independent calcium channel dependent on

tyrosine phosphorylation

6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Epo):

	embryogenesis	hematopoietic system	homeostasis/metabolism	lethality-prenatal/perinatal
liver/biliary system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005128	erythropoietin receptor binding	IEA	--
GO:0005179	hormone activity	IEA	--
GO:0005515	protein binding	IPI	17353931

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for EPO (Your Favorite Gene powered by Ingenuity)

Hypoxia Signaling in the Cardiovascular System
HIF1&alpha
Erythropoietin Signaling

GeneDecks EPO for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for EPO

5/113 Interacting proteins for EPO (P01588¹ ENSP00000252723³) via UniProtKB, MINT, and/or STRING (see all 113 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DOK2	O60496¹	EBI-1027362, EBI-1046024
EPOR	ENSP00000222139³	STRING (score=.999)
HIF1A	ENSP00000338018³	STRING (score=.999)
JAK2	ENSP00000371067³	STRING (score=.996)
ARNT	ENSP00000315637³	STRING (score=.99)

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5/14 Gene Ontology (GO) biological process terms (links to tree view) (see all 14 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IEA	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0006915	apoptosis	IEA	--
GO:0007165	signal transduction	NAS	3838366
GO:0007566	embryo implantation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for EPO
UniProtKB/Swiss-Prot: EPO_HUMAN, P01588

Pharmaceutical: Used for the treatment of anemia. Available under the names Epogen (Amgen), Epogin

(Chugai), Epomax (Elanex), Eprex (Janssen-Cilag), NeoRecormon or Recormon (Roche), Dynepo (Shire

Pharmaceuticals) and Procrit (Ortho Biotech). Variations in the glycosylation pattern of EPO

distinguishes these products. Epogen, Epogin, Eprex and Procrit are generically known as epoetin

alfa, NeoRecormon and Recormon as epoetin beta, Dynepo as epoetin delta and Epomax as epoetin

omega. Epoetin zeta is the name used for some 'biosimilars' forms of epoetin alfa and is available

under the names Silapo (Stada) and Retacrit (Hospira). Darbepoetin alfa is a form created by 5

substitutions (Asn-57, Thr-59, Val-114, Asn-115 and Thr-117) that create 2 new N-glycosylation

sites. It has a longer circulating half-life in vivo. It is available under the name Aranesp

(Amgen). EPO is being much misused as a performance-enhancing drug in endurance athletes

10/35 Novoseek chemical compound relationships for EPO gene (see all 35 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
iron	89.51	2380	10850644 (10), 8671972 (9), 9590194 (7), 8350509 (7) (see all 99)
ferric gluconate	72.80	18	18216316 (5), 19260610 (2), 12778887 (1), 18578008 (1) (see all 7)
cilag	72.60	6	1415368 (1), 1361846 (1), 1948755 (1), 9156931 (1) (see all 6)
oxygen	55.21	479	9350435 (6), 9777287 (6), 7757199 (5), 18973793 (4) (see all 99)
pixy321	51.22	6	10344557 (1), 10706891 (1), 12595310 (1), 7579445 (1) (see all 5)
23-diphosphoglycerate	50.94	33	2195935 (3), 11569479 (2), 15248067 (2), 8001533 (2) (see all 14)
ferric sulfate	49.52	11	8851333 (2), 10982248 (1), 7677965 (1), 8473781 (1) (see all 8)
tyrosine	46.10	294	8068943 (5), 8276859 (5), 8639815 (4), 7535525 (4) (see all 99)
cuprophan	45.92	24	9790077 (5), 9360100 (1), 9093890 (1), 1296348 (1) (see all 5)
aluminium	45.81	25	1775251 (4), 1967718 (3), 9156931 (2), 1870750 (1) (see all 19)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EPO)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EPO)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000799

Sigma-Aldrich siRNA and siRNA Panels for EPO

Sigma-Aldrich shRNA Panels and shRNA for EPO

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000799

REFSEQ mRNAs for EPO gene:

NM_000799.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000799

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000799
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000799
                                 untagged cDNA clone in CMV expression vector: NM_000799

Additional cDNA sequence:

BC093628.1 BC111937.1 BC143225.1 S65458.1 X02157.1

1 DOTS entry:

DT.452249

12 AceView cDNA sequences:

BM931641 NM_000799 X02157 T29272 AI620493 BX094354 BQ185758 AI400428

BM931504 W93118 AW951227 AA662379

highest scoring ESTs for EPO:

AI400428 AI620493 AW951227 BM931504 BM931641 BQ185758 BX094354 T29272 W93118 X02157

Unigene Cluster for EPO:

Erythropoietin

Hs.2303 [show with all ESTs]

Unigene Representative Sequence: X02157

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000252723

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

EPO expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EPO

¹ / ² / ³

5 probe-sets matching EPO gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1023_at²^{, 3}	U95-A	1	0.88	1.00	1.00	1.00	X02158	0.20	1.00	0.72	1
207257_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000799	0.60	1.00	0.82	1
217254_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
207257_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217254_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGGTCCAAGT

SOURCE GeneReport for Unigene cluster: Hs.2303
Expression variation in blood from EXPOLDB for EPO
UniProtKB/Swiss-Prot: EPO_HUMAN, P01588
Tissue specificity: Produced by kidney or liver of adult mammals and by liver of fetal or neonatal
mammals

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for EPO gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	EPO¹	--	erythropoietin	86.52(n) 82.45(a)	404002 NM_001006646.1 NP_001006647.1
chimpanzee (Pan troglodytes)	EPO¹	--	erythropoietin	99.48(n) 99.48(a)	463609 XM_519268.2 XP_519268.2
cow (Bos taurus)	EPO¹	--	erythropoietin	85.69(n) 80.1(a)	280784 NM_173909.2 NP_776334.1
rat (Rattus norvegicus)	Epo¹	--	erythropoietin	79.69(n) 81.25(a)	24335 NM_017001.1 NP_058697.1
mouse (Mus musculus)	Epo^{1, 5}	5 (78.00 cM)⁵	erythropoietin^{1, 5}	80.03(n)¹ 79.17(a)¹	13856¹ NM_007942.2¹ NP_031968.1¹ AF312033⁵ BC119265⁵ (see all 15)

About this table Species with no ortholog for EPO

ENSEMBL Gene Tree for EPO

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/30 NCBI SNPs in EPO are shown (see all 30 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 13)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1617640^1,2	A,C,F,H,O	100155234(-)	`CCAGAT/GGAGTG`	1	--	ng5¹		5		MN EU EA WA	602
--	rs4729606^1,2	A,C,F,H	100159726(+)	`TCCTTT/CACTCA`	1	--	ng3¹		4		EU EA WA	412
	rs551238^1,2	A,C,F,H	100159464(-)	`TGGAGA/CCACCT`	1	--	ng3¹		10		EA NA EU WA	818
	rs564449^1,2	C,F,H	100159074(+)	`CTGGAG/TAACTT`	1	--	ut3¹		10		NA EU EA WA	874
--	rs576236^1,2	A,C	100154911(+)	`gactaC/Taggcg`	1	--	ng5¹		0	--	--	--	--
	rs11976235^1,2	C	100158317(+)	`CCAGCC/TGTGGG`	1	P/L	mis¹ ese³		0	--	--	--	--
--	rs10249669^1,2	H	100154982(+)	`tgccaT/Agttgt`	1	--	ng5¹		4		EU EA WA	388
--	rs507392^1,2	A,C	100157872(-)	`accacC/Ttcacc`	1	--	int¹		0	--	--	--	--
--	rs34371939^1,2	--	100154880(+)	`ATCCTC/GCTGCC`	1	--	ng5¹		0	--	--	--	--
--	rs6977067^1,2	--	100154581(+)	`gcgggC/Ttgctg`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for EPO (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 133170 disorders: 612623

UniProtKB/Swiss-Prot: EPO_HUMAN, P01588

Genetic variation in EPO is associated with susceptbility to microvascular complications

of diabetes type 2 (MVCD2) [MIM:612623]; also called susceptibility to proliferative diabetic

retinopathy (PDR) or susceptbility to diabetic end-stage renal disease (ESRD). Significant

morbidity and mortality among patients with diabetes mellitus result largely from a greatly

increased incidence of microvascular complications. PDR and ESRD are two of the most common and

severe microvascular complications of diabetes. A high concordance exists in the development of

PDR and ESRD in diabetic patients, as well as strong familial aggregation of these complications,

suggesting a common underlying genetic mechanism. EPO is a potent angiogenic factor observed in

the diabetic human and mouse eye

10/95 Novoseek disease relationships for EPO gene (see all 95 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
anemia	96.86	5770	7557862 (7), 10827238 (7), 12713065 (7), 1421381 (6) (see all 99)
erythrocytosis	89.56	249	14564105 (7), 15712191 (5), 15477203 (4), 7518732 (4) (see all 99)
renal failure chronic	89.17	1008	1339766 (4), 8552143 (4), 10850644 (3), 2220877 (3) (see all 99)
iron deficiency	89.10	290	12647284 (4), 15784734 (4), 9352960 (3), 8524494 (3) (see all 99)
polycythemia	85.26	189	16231451 (4), 12393546 (4), 15217714 (3), 16769575 (3) (see all 99)
red cell aplasia	82.65	109	15172775 (4), 16449549 (3), 8596164 (2), 8488547 (2) (see all 77)
anemia severe	82.56	97	15792921 (2), 12234311 (2), 8938689 (2), 7933664 (2) (see all 76)
polycythemia vera	80.49	67	9475763 (4), 17980427 (2), 9731054 (2), 9292543 (2) (see all 44)
myelodysplastic syndromes	80.17	277	1961041 (3), 7505147 (3), 8398823 (2), 8411647 (2) (see all 99)
renal disease	79.10	463	16099877 (4), 15498082 (3), 16889570 (3), 15792912 (3) (see all 99)

About this table

Human Gene Mutation Database: EPO
Human Genome Epidemiology Navigator: EPO (39 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/3497 PubMed articles for EPO gene (see all 3497 ):

Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. (PubMed id 9799793)^{2, 3, 4} Glockner G....Rosenthal A. (1998)
Isolation and characterization of genomic and cDNA clones of human erythropoietin. (PubMed id 3838366)^{2, 3, 4} Jacobs K....Fritsch E.F. (1985)
Gene expression of mutant erythropoietin in hepatocellular carcinoma. (PubMed id 8396923)^{1, 3, 4} Funakoshi A.... Shimizu S. (1993)
Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications. (PubMed id 18458324)^{3, 4} Tong Z....Zhang K. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{3, 4} Hillier L.W.... Wilson R.K. (2003)
Efficiency of signalling through cytokine receptors depends critically on receptor orientation. (PubMed id 9774108)^{3, 4} Syed R.S.... Stroud R.M. (1998)
Structures and functional roles of the sugar chains of human erythropoietins. (PubMed id 1820196)^{3, 4} Takeuchi M. and Kobata A. (1991)
Comparative study of the asparagine-linked sugar chains of human erythropoietins purified from urine and the culture medium of recombinant Chinese hamster ovary cells. (PubMed id 3346214)^{3, 4} Takeuchi M....Kobata A. (1988)
Site-specific glycosylation of human recombinant erythropoietin: analysis of glycopeptides or peptides at each glycosylation site by fast atom bombardment mass spectrometry. (PubMed id 3219367)^{3, 4} Sasaki H.... Fukuda M. (1988)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2056	HGNC: 3415	AceView: EPO	Ensembl:ENSG00000130427	euGenes: HUgn2056
ECgene: EPO	H-InvDB: EPO

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for EPO	Genetics and Cytogenetics in Oncology and Haematology
R&D Systems' cytokine source book: Erythropoietin	http://www.rndsystems.com/molecule_detail.aspx?m=1405
Wikipedia	http://en.wikipedia.org/wiki/Erythropoietin

Licensable Technologies for EPO
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for EPO:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for EPO-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for EPO		Antibodies for EPO
	Explore super-pooled esiRNAs		Proteins for EPO
	Lentivirus-delivered shRNAs for EPO		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
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Antibodies for EPO

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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EPO Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for EPO

Summaries
for EPO

Genomic Location
for EPO

Proteins
for EPO

Protein Domains/
Families
for EPO

Gene Function
for EPO

Pathways & Interactions
for EPO

Drugs & Compounds
for EPO

Transcripts
for EPO

Expression
for EPO

Orthologs
for EPO

Paralogs
for EPO

SNPs/Variants
for EPO

Disorders & Mutations
for EPO

Medical News
for EPO

Publications
for EPO

Search for EPO

Genome Databases showing EPO

Other Databases showing EPO

Specialized Databases showing EPO

Licensable Technologies
for EPO

Services
for EPO

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EPO Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor EPO

Summariesfor EPO

Genomic Locationfor EPO

Proteinsfor EPO

Protein Domains/Familiesfor EPO

Gene Functionfor EPO

Pathways & Interactionsfor EPO

Drugs & Compoundsfor EPO

Transcriptsfor EPO

Expression for EPO

Orthologsfor EPO

Paralogsfor EPO

SNPs/Variantsfor EPO

Disorders & Mutationsfor EPO

Medical Newsfor EPO

Publicationsfor EPO

Search for EPO

Genome Databases showing EPO

Other Databases showing EPO

Specialized Databases showing EPO

Licensable Technologiesfor EPO

Servicesfor EPO

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EPO

Summaries
for EPO

Genomic Location
for EPO

Proteins
for EPO

Protein Domains/
Families
for EPO

Gene Function
for EPO

Pathways & Interactions
for EPO

Drugs & Compounds
for EPO

Transcripts
for EPO

Expression
for EPO

Orthologs
for EPO

Paralogs
for EPO

SNPs/Variants
for EPO

Disorders & Mutations
for EPO

Medical News
for EPO

Publications
for EPO

Licensable Technologies
for EPO

Services
for EPO