Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EPN3 Gene

protein-coding   GIFtS: 56
GCID: GC17P048610

Epsin 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Epsin 31 2
EPS-15-Interacting Protein 32 3
epsin-32

External Ids:    HGNC: 182351   Entrez Gene: 550402   Ensembl: ENSG000000492837   OMIM: 6072645   UniProtKB: Q9H2013   

Export aliases for EPN3 gene to outside databases

Previous GC identifers: GC17P048323 GC17P051091 GC17P048952 GC17P049084 GC17P045965 GC17P043978


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for EPN3 Gene: 
EPN3 (epsin 3) is a protein-coding gene. Diseases associated with EPN3 include basal cell carcinoma, and ulcerative colitis, and among its related super-pathways are Sertoli-Sertoli Cell Junction Dynamics and Retrograde neurotrophin signalling. GO annotations related to this gene include lipid binding. An important paralog of this gene is CLINT1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EPN3 gene promoter:
         SRF   ER-alpha   p53   Pax-5   STAT1beta   AREB6   PPAR-alpha   IRF-7A   ARP-1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): EPN3 promoter sequence
   Search SABiosciences Chromatin IP Primers for EPN3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.33   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.33

EPN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPN3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P048610:  view genomic region     (about GC identifiers)

Start:
48,609,904 bp from pter      End:
48,621,111 bp from pter
Size:
11,208 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EPN3_HUMAN, Q9H201 (See protein sequence)
Recommended Name: Epsin-3  
Size: 632 amino acids; 68222 Da
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle.
Nucleus (Probable). Note=Concentrated in the perinuclear region and associated with clathrin-coated vesicles
close to the cell periphery. May shuttle to the nucleus
Secondary accessions: A8K6J3 A8KAB2 Q9BVN6 Q9NWK2
Alternative splicing: 2 isoforms:  Q9H201-1   Q9H201-2   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for EPN3: NX_Q9H201

Explore proteomics data for EPN3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H201

  • EPN3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EPN3 Protein Expression
    REFSEQ proteins: NP_060427.2  
    ENSEMBL proteins: 
     ENSP00000268933   ENSP00000426762   ENSP00000424306   ENSP00000422682   ENSP00000421936  
     ENSP00000422201   ENSP00000421933   ENSP00000426676   ENSP00000422601   ENSP00000421515  
     ENSP00000460911   ENSP00000439512   ENSP00000440540  

    Human Recombinant Protein Products for EPN3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for EPN3
    OriGene Protein Over-expression Lysate for EPN3
    OriGene MassSpec for EPN3 
    OriGene Custom Protein Services for EPN3
    GenScript Custom Purified and Recombinant Proteins Services for EPN3
    Novus Biologicals EPN3 Proteins
    Novus Biologicals EPN3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EPN3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0030136clathrin-coated vesicle IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    EPN3 for ontologies           About GeneDecksing



    EPN3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for EPN3
    GenScript Custom Superior Antibodies Services for EPN3
    Novus Biologicals EPN3 Antibodies
    Abcam antibodies for EPN3
    Cloud-Clone Corp. Antibodies for EPN3 
    ThermoFisher Antibodies for EPN3
    LSBio Antibodies in human, mouse, rat for EPN3 

    Assay Products for EPN3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for EPN3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for EPN3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EPN3 
    Cloud-Clone Corp. CLIAs for EPN3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR027318 Epsin-3_metazoa
     IPR003903 Ubiquitin-int_motif
     IPR001026 Epsin_dom_N
     IPR008942 ENTH_VHS
     IPR013809 Epsin-like_N

    Graphical View of Domain Structure for InterPro Entry Q9H201

    ProtoNet protein and cluster: Q9H201

    3 Blocks protein domains:
    IPB001026 Epsin N-terminal homology
    IPB003903 Ubiquitin interacting motif
    IPB013809 Epsin-like


    UniProtKB/Swiss-Prot: EPN3_HUMAN, Q9H201
    Similarity: Belongs to the epsin family
    Similarity: Contains 1 ENTH (epsin N-terminal homology) domain
    Similarity: Contains 2 UIM (ubiquitin-interacting motif) repeats


    EPN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EPN3_HUMAN, Q9H201
    Induction: In keratinocytes, by wounding or contact with collagen

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005543phospholipid binding ----
    GO:0008289lipid binding IEA--
         
    EPN3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for EPN3:
     Increased cell death HMECs cel  Increased cell number in G2M,  

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Epn3):
     normal 

    EPN3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Epn3tm1.1Pdc for EPN3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for EPN3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EPN3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EPN3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EPN3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EPN3
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate EPN3 (see all 9):
    hsa-miR-345 hsa-miR-3164 hsa-miR-16-2* hsa-miR-888 hsa-miR-1224-5p hsa-miR-3160-3p hsa-miR-145 hsa-miR-195*
    SwitchGear 3'UTR luciferase reporter plasmidEPN3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for EPN3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPN3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EPN3
    Sirion Biotech Customized adenovirus for overexpression of EPN3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for EPN3 (see all 7)
    OriGene ORF clones in mouse, rat for EPN3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EPN3 (NM_017957)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPN3
    Sirion Biotech Customized lentivirus for stable overexpression of EPN3 
                         Customized lentivirus expression plasmids for stable overexpression of EPN3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for EPN3
    Search LifeMap BioReagents cell lines for EPN3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPN3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EPN3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Germ Cell-Sertoli Cell Junction Dynamics0.38
    2Endocytic Trafficking of EGFR
    Endocytic Trafficking of EGFR0.36
    3PAK Pathway
    Epithelial Adherens Junctions0.36
    4Notch Signaling Pathways
    Notch Signaling Pathways
    5Endocytosis
    Endocytosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for EPN3
        Notch Signaling Pathways

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EPN3
        Endocytic Trafficking of EGFR
    Sertoli-Sertoli Cell Junction Dynamics
    Germ Cell-Sertoli Cell Junction Dynamics
    Epithelial Adherens Junctions


    1         Kegg Pathway  (Kegg details for EPN3):
        Endocytosis


    EPN3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EPN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/22 Interacting proteins for EPN3 (Q9H2012, 3 ENSP000002689334) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LAPTM5Q135712, 3MINT-62175 I2D: score=3 
    RNF11Q9Y3C52, 3MINT-60881 I2D: score=3 
    CSF1RENSP000002863014STRING: ENSP00000286301
    EGFRENSP000002754934STRING: ENSP00000275493
    ERBB4ENSP000003422354STRING: ENSP00000342235
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EPN3

    Search CenterWatch for drugs/clinical trials and news about EPN3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EPN3 gene: 
    NM_017957.2  

    Unigene Cluster for EPN3:

    Epsin 3
    Hs.670090  [show with all ESTs]
    Unigene Representative Sequence: NM_017957
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000268933(uc002ira.4 uc010wms.2 uc010wmt.2 uc010wmu.2)
    ENST00000503246 ENST00000503690 ENST00000514874 ENST00000510462 ENST00000515028
    ENST00000571402 ENST00000507998 ENST00000512291 ENST00000512379 ENST00000510045
    ENST00000504857 ENST00000507709 ENST00000511414 ENST00000515126 ENST00000507467
    ENST00000574464 ENST00000537145
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EPN3
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate EPN3 (see all 9):
    hsa-miR-345 hsa-miR-3164 hsa-miR-16-2* hsa-miR-888 hsa-miR-1224-5p hsa-miR-3160-3p hsa-miR-145 hsa-miR-195*
    SwitchGear 3'UTR luciferase reporter plasmidEPN3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for EPN3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPN3
    Clone
    Products:
         
    OriGene clones in human, mouse for EPN3 (see all 7)
    OriGene ORF clones in mouse, rat for EPN3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EPN3 (NM_017957)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPN3
    Sirion Biotech Customized lentivirus for stable overexpression of EPN3 
                         Customized lentivirus expression plasmids for stable overexpression of EPN3 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for EPN3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EPN3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPN3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPN3

    Additional mRNA sequence: 

    AF324241.1 AK000785.1 AK291658.1 AK292977.1 AK295730.1 AK296346.1 AK300642.1 BC110602.2 

    7 DOTS entries:

    DT.75169965  DT.100748087  DT.120939480  DT.40251845  DT.120939484  DT.100692809  DT.120939482 

    24/368 AceView cDNA sequences (see all 368):

    BM844988 BU629958 BI520463 BM754702 BQ000242 AI352313 BG912187 BE502447 
    AF324241 CB155619 BQ428017 BG287870 CF145280 CA503343 BU731005 NM_022827 
    BU539570 BQ003399 BM691701 CK000096 AA429592 BX343408 CA391562 AL045098 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for EPN3 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                          -     -     -     -           -     -     -                                                                                       
    SP4:                                      -     -           -     -     -                                                                                       
    SP5:                                      -     -                 -     -                                                                                       

    ExUns: 13
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for EPN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EPN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCACTGGGG
    EPN3 Expression
    About this image


    See EPN3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EPN3

    SOURCE GeneReport for Unigene cluster: Hs.670090

    UniProtKB/Swiss-Prot: EPN3_HUMAN, Q9H201
    Tissue specificity: Detected in migrating keratinocytes from wounded skin, but not in differentiating
    keratinocytes or in normal skin. Detected in chronic wounds, basal cell carcinoma and ulcerative colitis

        SABiosciences Custom PCR Arrays for EPN3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for EPN3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EPN3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPN3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPN3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for EPN3 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Epn31 , 5 epsin 31, 5 85.61(n)1
    88.28(a)1
      11 (58.90 cM)5
    718891  NM_027984.31  NP_082260.11 
     944895995 
    chicken
    (Gallus gallus)
    Aves LOC1008592901 epsin-3-like 70.99(n)
    68.23(a)
      100859290  XM_003642365.1  XP_003642413.1 
    lizard
    (Anolis carolinensis)
    Reptilia EPN36
    Uncharacterized protein
    65(a)
    1 ↔ 1
    2(116438937-116471400)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5714531 epsin-3-like 65.84(n)
    65.09(a)
      571453  XM_695043.4  XP_700135.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta lqf3 neurotransmitter secretion 36(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea T04C10.2b3 Yeast hypothetical protein L8167.6 like 39(a)
    (best of 2)
      X(14851850-14853718)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ENT36
    Protein containing an N-terminal epsin-like domain...
    23(a)
    1 → many
    X(654737-655963)


    ENSEMBL Gene Tree for EPN3 (if available)
    TreeFam Gene Tree for EPN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EPN3 gene
    CLINT12  EPN12  EPN22  ENTHD12  
    2 SIMAP similar genes for EPN3 using alignment to 12 protein entries:     EPN3_HUMAN (see all proteins):
    EPN2    EPN1

    EPN3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/371 SNPs in EPN3 are shown (see all 371)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1881319691,2
    --48609372(+) AAACTA/GTCTGG 1 -- us2k10--------
    rs1820017671,2
    C--48609422(+) TTCATA/GCTACC 1 -- us2k10--------
    rs1862800911,2
    --48609425(+) ATGCTA/TCCTCC 1 -- us2k10--------
    rs1433653291,2
    C--48609457(+) CAGGCC/TAGAAA 1 -- us2k10--------
    rs47941571,2
    C,F,H--48609558(+) GTGAAC/GAGCAC 1 -- us2k121Minor allele frequency- G:0.15NA NS EA WA CSA 909
    rs99007471,2
    C,A,H--48609789(+) GGAATA/GTCCCT 1 -- us2k1 tfbs316Minor allele frequency- G:0.17MN EA NA WA CSA 737
    rs1907075501,2
    --48609817(+) CCTCCA/CGGCCC 1 -- us2k10--------
    rs1816056241,2
    --48609851(+) GTGGGA/GGTGTT 1 -- us2k10--------
    rs129530661,2
    C,F,H--48609962(+) GGCGGT/CCAACA 1 -- us2k115Minor allele frequency- C:0.12NS EA NA WA CSA 759
    rs126012861,2
    C,H--48610033(+) CCTGCG/ACTTCC 1 -- us2k113Minor allele frequency- A:0.15NA WA CSA EA 377

    HapMap Linkage Disequilibrium report for EPN3 (48609904 - 48621111 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for EPN3:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv465e201CNV Deletion23290073
    esv2716036CNV Deletion23290073
    esv2716034CNV Deletion23290073
    nsv908605CNV Loss21882294
    dgv3230n71CNV Loss21882294
    dgv3229n71CNV Loss21882294
    nsv833477CNV Loss17160897
    nsv908600CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing EPN3
    DNA2.0 Custom Variant and Variant Library Synthesis for EPN3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607264    OMIM disorders: --

    2 diseases for EPN3:    About MalaCards
    basal cell carcinoma    ulcerative colitis


    EPN3 for disorders           About GeneDecksing


    Export disorders for EPN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EPN3 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with EPN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Epsin 3 is a novel extracellular matrix-induced transcript specific to wounded epithelia. (PubMed id 11359770)1, 2, 3, 9 Spradling K.D.... Pilcher B.K. (2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Cloning and initial characterization of human epsin 3, a novel matrix-induced keratinocyte specific transcript (PubMed id 10951261)1, 3 Spradling K.D....Pilcher B.K. (2000)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Selective high-level expression of epsin 3 in gastric parietal cells, where it is localized at endocytic sites of apical canaliculi. (PubMed id 21115825)1 Ko G....De Camilli P. (2010)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55040 HGNC: 18235 AceView: EPN3andSSP411 Ensembl:ENSG00000049283 euGenes: HUgn55040
    ECgene: EPN3 Kegg: 55040 H-InvDB: EPN3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EPN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EPN3 gene:
    Search GeneIP for patents involving EPN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for EPN3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for EPN3  
     OriGene MassSpec something-or-other for EPN3   OriGene clones in human, mouse for EPN3  
     OriGene qSTAR qPCR primer pairs in human, mouse for EPN3   OriGene Purified Protein for EPN3  
     OriGene ORF clones in mouse, rat for EPN3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for EPN3   OriGene Custom Protein Services for EPN3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EPN3
     QIAGEN SeqTarget long-range PCR primers for resequencing EPN3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPN3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPN3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPN3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPN3
     GenScript Custom Purified and Recombinant Proteins Services for EPN3 GenScript cDNA clones with any tag delivered in your preferred vector for EPN3
     GenScript Custom Assay Services for EPN3 GenScript Custom Superior Antibodies Services for EPN3
     GenScript Custom overexpressing Cell Line Services for EPN3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in EPN3 promoter
     Search Chromatin IP Primers for EPN3
     RT2 qPCR Primer Assay in human, mouse, rat EPN3
     Search GNC Networks for EPN3
     SABiosciences PCR Arrays including human, mouse, rat EPN3
     Search Tocris compounds for EPN3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     EPN3 antibodies
     EPN3 proteins
     EPN3 lysates
     Antibodies for EPN3
     See all of Abcam's Antibodies, Kits and Proteins for EPN3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for EPN3
     Antibodies for EPN3
     ELISAs for EPN3
     CLIAs for EPN3
     Search LifeMap BioReagents cell lines for EPN3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPN3
     SwitchGear 3'UTR luciferase reporter plasmids for EPN3
     SwitchGear Promoter luciferase reporter plasmids for EPN3
     ThermoFisher Antibodies for EPN3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPN3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for EPN3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EPN3
    Customized:
     lentivirus for stable overexpression of EPN3
     lentivirus expression plasmids for stable overexpression of EPN3
     adenovirus for overexpression of EPN3
     LSBio Antibodies in human, mouse, rat for EPN3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      EPN3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4