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Aliases for EPN3 Gene

Aliases for EPN3 Gene

  • Epsin 3 2 3
  • EPS-15-Interacting Protein 3 3 4
  • Epsin-3 3

External Ids for EPN3 Gene

Previous GeneCards Identifiers for EPN3 Gene

  • GC17P048323
  • GC17P051091
  • GC17P048952
  • GC17P049084
  • GC17P045965
  • GC17P048610
  • GC17P043978

Summaries for EPN3 Gene

GeneCards Summary for EPN3 Gene

EPN3 (Epsin 3) is a Protein Coding gene. Among its related pathways are PAK Pathway and Endocytosis. GO annotations related to this gene include lipid binding. An important paralog of this gene is ENTHD1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPN3 Gene

Genomics for EPN3 Gene

Regulatory Elements for EPN3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EPN3 Gene

50,532,543 bp from pter
50,543,750 bp from pter
11,208 bases
Plus strand

Genomic View for EPN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EPN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPN3 Gene

Proteins for EPN3 Gene

  • Protein details for EPN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K6J3
    • A8KAB2
    • Q9BVN6
    • Q9NWK2

    Protein attributes for EPN3 Gene

    632 amino acids
    Molecular mass:
    68222 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EPN3 Gene


neXtProt entry for EPN3 Gene

Proteomics data for EPN3 Gene at MOPED

Post-translational modifications for EPN3 Gene

  • Ubiquitination at Lys23
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for EPN3 Gene

Domains for EPN3 Gene

Suggested Antigen Peptide Sequences for EPN3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 ENTH (epsin N-terminal homology) domain.
  • Belongs to the epsin family.
  • Contains 1 ENTH (epsin N-terminal homology) domain.
  • Contains 2 UIM (ubiquitin-interacting motif) domains.
  • Belongs to the epsin family.
genes like me logo Genes that share domains with EPN3: view

No data available for Gene Families for EPN3 Gene

Function for EPN3 Gene

Molecular function for EPN3 Gene

UniProtKB/Swiss-Prot Induction:
In keratinocytes, by wounding or contact with collagen.

Gene Ontology (GO) - Molecular Function for EPN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20709745
GO:0005543 phospholipid binding --
GO:0008289 lipid binding IEA --
GO:1990175 EH domain binding IEA --
genes like me logo Genes that share ontologies with EPN3: view

Phenotypes for EPN3 Gene

MGI mutant phenotypes for EPN3:
inferred from 1 alleles
GenomeRNAi human phenotypes for EPN3:
genes like me logo Genes that share phenotypes with EPN3: view

Animal Models for EPN3 Gene

MGI Knock Outs for EPN3:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EPN3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for EPN3 Gene

Localization for EPN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPN3 Gene

Cytoplasm. Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Note=Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the cell periphery. May shuttle to the nucleus.

Subcellular locations from

Jensen Localization Image for EPN3 Gene COMPARTMENTS Subcellular localization image for EPN3 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for EPN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11359770
GO:0005905 coated pit IEA --
GO:0019897 extrinsic component of plasma membrane IDA 20709745
GO:0030136 clathrin-coated vesicle IDA 11359770
GO:0048471 perinuclear region of cytoplasm IDA 11359770
genes like me logo Genes that share ontologies with EPN3: view

Pathways for EPN3 Gene

genes like me logo Genes that share pathways with EPN3: view

Pathways by source for EPN3 Gene

Interacting Proteins for EPN3 Gene

Gene Ontology (GO) - Biological Process for EPN3 Gene


Transcripts for EPN3 Gene

Unigene Clusters for EPN3 Gene

Epsin 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EPN3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EPN3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - - - - -
SP8: - - - - - - -
SP9: -
SP10: - -
SP11: - - - - - - - -
SP12: -

ExUns: 13

Relevant External Links for EPN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EPN3 Gene

mRNA expression in normal human tissues for EPN3 Gene

mRNA differential expression in normal tissues according to GTEx for EPN3 Gene

This gene is overexpressed in Esophagus - Mucosa (7.7), Stomach (7.4), and Skin - Sun Exposed (Lower leg) (4.4).

Protein differential expression in normal tissues for EPN3 Gene

This gene is overexpressed in Urinary Bladder (55.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EPN3 Gene

SOURCE GeneReport for Unigene cluster for EPN3 Gene Hs.670090

mRNA Expression by UniProt/SwissProt for EPN3 Gene

Tissue specificity: Detected in migrating keratinocytes from wounded skin, but not in differentiating keratinocytes or in normal skin. Detected in chronic wounds, basal cell carcinoma and ulcerative colitis.
genes like me logo Genes that share expressions with EPN3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Expression partners for EPN3 Gene

Orthologs for EPN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EPN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EPN3 35
  • 83.98 (n)
  • 83.19 (a)
EPN3 36
  • 83 (a)
(Canis familiaris)
Mammalia EPN3 35
  • 89.74 (n)
  • 91.51 (a)
EPN3 36
  • 90 (a)
(Mus musculus)
Mammalia Epn3 35
  • 85.66 (n)
  • 88.28 (a)
Epn3 16
Epn3 36
  • 86 (a)
(Pan troglodytes)
Mammalia EPN3 35
  • 96.51 (n)
  • 95.4 (a)
(Rattus norvegicus)
Mammalia Epn3 35
  • 84.23 (n)
  • 87.75 (a)
(Monodelphis domestica)
Mammalia EPN3 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia EPN3 36
  • 68 (a)
(Gallus gallus)
Aves EPN3 35
  • 70.22 (n)
  • 67.85 (a)
EPN3 36
  • 66 (a)
(Anolis carolinensis)
Reptilia EPN3 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia epn3 35
  • 54.65 (n)
  • 52.47 (a)
(Danio rerio)
Actinopterygii LOC571453 35
  • 63.35 (n)
  • 60.54 (a)
EPN3 (1 of 2) 36
  • 53 (a)
EPN3 (2 of 2) 36
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta lqf 37
  • 36 (a)
lqf 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea T04C10.2a 37
  • 39 (a)
T04C10.2b 37
  • 39 (a)
epn-1 36
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENT3 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
Species with no ortholog for EPN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EPN3 Gene

Gene Tree for EPN3 (if available)
Gene Tree for EPN3 (if available)

Paralogs for EPN3 Gene

Paralogs for EPN3 Gene

genes like me logo Genes that share paralogs with EPN3: view

Variants for EPN3 Gene

Sequence variations from dbSNP and Humsavar for EPN3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs532982612 -- 50,536,461(+) AACAC(A/G)GCAGC utr-variant-5-prime
rs533127056 -- 50,541,752(+) CCTCC(A/G)CCGGA intron-variant
rs532973862 -- 50,541,112(+) CCAGG(A/C)AGGGC intron-variant
rs532668112 -- 50,535,776(+) ATAGG(C/T)GTTGA intron-variant
rs532533264 -- 50,535,042(+) TTCTG(A/C)AAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EPN3 Gene

Variant ID Type Subtype PubMed ID
nsv908600 CNV Gain 21882294
dgv3229n71 CNV Loss 21882294
nsv833477 CNV Loss 17160897
dgv3230n71 CNV Loss 21882294
esv2716034 CNV Deletion 23290073
dgv465e201 CNV Deletion 23290073
esv2716036 CNV Deletion 23290073
nsv908605 CNV Loss 21882294

Relevant External Links for EPN3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPN3 Gene

Disorders for EPN3 Gene

No disorders were found for EPN3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for EPN3 Gene

Publications for EPN3 Gene

  1. Epsin 3 is a novel extracellular matrix-induced transcript specific to wounded epithelia. (PMID: 11359770) Spradling K.D. … Pilcher B.K. (J. Biol. Chem. 2001) 2 3 4 23
  2. Cloning and initial characterization of human epsin 3, a novel matrix-induced keratinocyte specific transcript (PMID: 10951261) Spradling K.D. … Pilcher B.K. (J. Invest. Dermatol. 2000) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for EPN3 Gene

Sources for EPN3 Gene

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