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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EPN2 Gene

protein-coding   GIFtS: 55
GCID: GC17P019140

epsin 2
  Search for EPN2
in
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 Human Malady Compendium 
Biological research products
for EPN2    

Aliases
for EPN2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Epsin 21 2
KIAA10651 3 5
EHB211 2
EPS-15-Interacting Protein 22 3
Eps15 Binding Protein2
Epsin-21

External Ids:    HGNC: 186391   Entrez Gene: 229052   Ensembl: ENSG000000721347   OMIM: 6072635   UniProtKB: O952083   

Export aliases for EPN2 gene to outside databases

Previous GC identifers: GC17P019198 GC17P020612 GC17P019045 GC17P019302 GC17P019081 GC17P018522


Summaries
for EPN2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for EPN2:
This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The
protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the
cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this
gene results in multiple transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: EPN2_HUMAN, O95208
Function: Plays a role in the formation of clathrin-coated invaginations and endocytosis

Gene Wiki entry for EPN2


Genomic Views
for EPN2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EPN2 gene promoter:
         Sp1   Bach2   Egr-1   E47   Egr-4   N-Myc   Egr-2   CP2   Hand1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EPN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for EPN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

EPN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPN2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P019140:  view genomic region     (about GC identifiers)

Start:
 19,118,928 bp from pter      End:
 19,240,028 bp from pter
Size:
 121,101 bases      Orientation:
 plus strand

Proteins
for EPN2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: EPN2_HUMAN, O95208 (See protein sequence)
Recommended Name: Epsin-2  
Size: 641 amino acids; 68482 Da
Subunit: Binds EPS15 (By similarity). Binds AP-2 and clathrin
Subcellular location: Cytoplasm. Cytoplasmic vesicle, clathrin-coated vesicle. Note=In punctate structures throughout
the cell, associated with clathrin-coated vesicles, and particularly concentrated in the region of the Golgi complex
Sequence caution: Sequence=BAA83017.2; Type=Erroneous initiation;
Secondary accessions: O95207 Q9H7Z2 Q9UPT7
Alternative splicing: 3 isoforms:  O95208-1   O95208-2   O95208-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EPN2: NX_O95208

Post-translational modifications:

  • Ubiquitinated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95208

    • EPN2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001096134.1  NP_055779.2  NP_683723.2  

    ENSEMBL proteins: 
     ENSP00000462465   ENSP00000464206   ENSP00000462426   ENSP00000320543   ENSP00000463141  
     ENSP00000463627   ENSP00000463769   ENSP00000378980   ENSP00000378990   ENSP00000460193  
     ENSP00000459678   ENSP00000462958   ENSP00000462606   ENSP00000462392   ENSP00000378982  
     ENSP00000378988   ENSP00000459542   ENSP00000261495  

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    OriGene Purified Proteins (see all 2): EPN2
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    Novus Biologicals EPN2 Protein
    Novus Biologicals EPN2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for EPN2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030128clathrin coat of endocytic vesicle ----
    GO:0030136clathrin-coated vesicle IEA--


    EPN2 for ontologies           About GeneDecksing



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    Uscn Antibodies for EPN2
    ThermoFisher Antibody for EPN2

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    Uscn ELISAs and CLIAs for EPN2

    Protein Domains /
    Families
    for EPN2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    EPN2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR003903 Ubiquitin-int_motif
     IPR001026 Epsin_dom_N
     IPR008942 ENTH_VHS
     IPR013809 Epsin-like_N

    Graphical View of Domain Structure for InterPro Entry O95208

    ProtoNet protein and cluster: O95208

    3 Blocks protein families:
    IPB001026 Epsin N-terminal homology
    IPB003903 Ubiquitin interacting motif
    IPB013809 Epsin-like


    UniProtKB/Swiss-Prot: EPN2_HUMAN, O95208
    Domain: The NPF repeat domain is involved in EPS15 binding
    Domain: The DPW repeat domain is involved in AP-2 and clathrin binding
    Similarity: Belongs to the epsin family
    Similarity: Contains 1 ENTH (epsin N-terminal homology) domain
    Similarity: Contains 2 UIM (ubiquitin-interacting motif) repeats


    Function
    for EPN2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: EPN2_HUMAN, O95208
    Function: Plays a role in the formation of clathrin-coated invaginations and endocytosis

    miRNA
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    hsa-miR-323-3p hsa-miR-631 hsa-miR-485-3p hsa-miR-4305 hsa-miR-30d hsa-miR-342-3p hsa-miR-3161 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: EPN2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EPN2 (see all 7)
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for EPN2

    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008289lipid binding IEA--


    EPN2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Epn2tm1Ocr for EPN2
         8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Epn2):
     cardiovascular system  cellular  embryogenesis  growth/size  mortality/aging 
     nervous system  normal  reproductive system 

    EPN2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for EPN2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Sertoli-Sertoli Cell Junction Dynamics
    		Sertoli-Sertoli Cell Junction Dynamics1.00
    		Germ Cell-Sertoli Cell Junction Dynamics0.38
    2Endocytosis
    		Endocytosis1.00
    3PAK Pathway
    		Epithelial Adherens Junctions0.36
    4Transport of MHC II:Ii complex along Golgi to TGN
    		Endocytic Trafficking of EGFR0.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EPN2
        Endocytic Trafficking of EGFR
    Sertoli-Sertoli Cell Junction Dynamics
    Germ Cell-Sertoli Cell Junction Dynamics
    Epithelial Adherens Junctions


    1         Kegg Pathway  (Kegg details for EPN2):
        Endocytosis


    EPN2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EPN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/83 Interacting proteins for EPN2 (O952083 ENSP000003205434) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLTCQ006103, ENSP000002691224I2D: score=3 STRING: ENSP00000269122
    YWHAGP619813, ENSP000003063304I2D: score=1 STRING: ENSP00000306330
    EPS15P425663, ENSP000003607984I2D: score=3 STRING: ENSP00000360798
    TFAP2AP055493, ENSP000003689244I2D: score=1 STRING: ENSP00000368924
    TUBA1BP683633, ENSP000003367994I2D: score=2 STRING: ENSP00000336799
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0006897endocytosis IEA--
    GO:0007219Notch signaling pathway IEA--
    GO:0030100regulation of endocytosis ----
    GO:0048568embryonic organ development IEA--


    EPN2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for EPN2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EPN2
    Search CenterWatch for drugs/clinical trials and news about EPN2 

    Transcripts
    for EPN2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for EPN2 gene (3 alternative transcripts): 
    NM_001102664.1  NM_014964.4  NM_148921.3  

    Unigene Cluster for EPN2:

    Epsin 2
    Hs.743983  [show with all ESTs]
    Unigene Representative Sequence: NM_014964
    18/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):
    ENST00000582015 ENST00000399085 ENST00000399086 ENST00000584707 ENST00000584633
    ENST00000441293 ENST00000314728(uc002gvd.4 uc002gvh.1) ENST00000582659
    ENST00000583197 ENST00000577692 ENST00000580579 ENST00000395618 ENST00000395628
    ENST00000582234 ENST00000494192 ENST00000575595 ENST00000581024 ENST00000577244


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EPN2
    8/79 QIAGEN miScript miRNA Assays for microRNAs that regulate EPN2 (see all 79):
    hsa-miR-323-3p hsa-miR-631 hsa-miR-485-3p hsa-miR-4305 hsa-miR-30d hsa-miR-342-3p hsa-miR-3161 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: EPN2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EPN2 (see all 7)
    OriGene shRNA RFP: EPN2
    OriGene siRNA: EPN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPN2
    Clone
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    Primer
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    Additional cDNA sequence: 

    AB028988.1 AF062084.1 AF062085.1 AK001491.1 AK001996.1 AK024115.1 AK092366.1 AK295652.1 
    AK298006.1 AK307455.1 BC015488.1 BC070036.1 BC093972.1 BC093974.1 BC143263.1 BC143264.1 

    12 DOTS entries:

    DT.95178212  DT.410574  DT.97796441  DT.100728205  DT.99934337  DT.100785108  DT.86857752  DT.91859993 
    DT.92044037  DT.99949166  DT.120962142  DT.99972911 

    24/195 AceView cDNA sequences (see all 195):

    AK001996 NM_148921 AB028988 BF525989 BM674323 AI953933 BU956699 Z41748 
    BX334545 BF915866 N53895 NM_014964 BU608533 BQ718886 BU172684 CR592872 
    BM993032 CR621978 BQ189257 BM694815 BQ636510 AI880055 AI652231 CA421459 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for EPN2 (see all 13)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^ 18a ·
    SP1:                    -     -     -     -                                                     -                 -                             -               
    SP2:                    -     -     -     -                                   -                 -                 -                                             
    SP3:                                                                          -                 -                 -                             -               
    SP4:                    -     -     -     -     -     -     -     -     -     -                 -                 -                                             
    SP5:                    -     -     -                                                                                                                           

    ExUns: 18b ^ 19a · 19b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for EPN2

    Expression
    for EPN2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EPN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See EPN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EPN2

    SOURCE GeneReport for Unigene cluster: Hs.743983

    UniProtKB/Swiss-Prot: EPN2_HUMAN, O95208
    Tissue specificity: Highest expression is found in brain. Detected at lower levels in lung and liver

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    In Situ
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    Orthologs
    for EPN2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EPN2 gene from 8/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves EPN21 epsin 2 77.27(n)
    84.31(a)    		   416524  NM_001012788.1  NP_001012806.1 
    lizard
    (Anolis carolinensis)    		 Reptilia EPN26
    		 --
    		 74(a)
    		 1 ↔ 1
    		 GL343618.1(384652-397302)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.52902 Transcribed sequence with weak similarity to protein more 78.22(n)    141991236 
    zebrafish
    (Danio rerio)    		 Actinopterygii epn21 epsin 2 67.64(n)
    71.48(a)    		   560542  XM_681373.4  XP_686465.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta lqf6
    		 liquid facets
    		 29(a)
    		 1 → many
    		 3L(7521880-7533112)
    worm
    (Caenorhabditis elegans)    		 Secernentea T04C10.2b3
    epn-11    		 Yeast hypothetical protein L8167.6 like3
    Protein EPN-11    		 37(a)
    (best of 2)3
    52.49(n)1
    49(a)1    		   X(14851850-14853718)3
    1815771  NM_078058.21  NP_510459.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G592901 clathrin interactor EPSIN 3 46.93(n)
    41.26(a)    		   825098  NM_115791.2  NP_567079.1 
    rice
    (Oryza sativa)    		 Liliopsida Os02g08066001 hypothetical protein 41.09(n)
    32.56(a)    		   9268417  NM_001186265.1  NP_001173194.1 


    ENSEMBL Gene Tree for EPN2 (if available)
    TreeFam Gene Tree for EPN2 (if available) 

    Paralogs
    for EPN2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EPN2 gene
    CLINT12  EPN12  EPN32  ENTHD12  
    2 SIMAP similar genes for EPN2 using alignment to 20 protein entries:     EPN2_HUMAN (see all proteins):
    EPN3    EPN1

    EPN2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for EPN2
    PGOHUM00000235037


    Genomic Variants
    for EPN2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1524 NCBI SNPs in EPN2 are shown (see all 1524)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1919826181,2
    		--19140648(+) CTCGGG/TGCCTC 3 -- us2k10--------
    rs42688161,2
    		C--19140683(+) CACGCG/CTCCGG 3 -- us2k11Minor allele frequency- C:0.50NA 2
    rs1839057391,2
    		--19140753(+) GGCGGG/TGGCGG 3 -- ut510--------
    rs1878463861,2
    		--19141214(+) CCGCCC/TCCTCC 3 -- int10--------
    rs1176782711,2
    		F,--19141236(+) TCCTCC/TTCTCC 3 -- int11Minor allele frequency- T:0.12EA 120
    rs287064271,2
    		C,--19141277(+) AGCCTG/AGTCTC 3 -- int13Minor allele frequency- A:0.20WA NA 122
    rs1923290931,2
    		--19141306(+) AGCCCA/GGTCCG 3 -- int10--------
    rs1844415411,2
    		--19141318(+) GCGCCC/TTCCGG 3 -- int10--------
    rs1134188381,2
    		C--19141330(-) CTCCCC/TCGATT 3 -- int10--------
    rs1380838681,2
    		C,--19141345(+) CCTTA-/TCTCTGT 3 -- int10--------

    HapMap Linkage Disequilibrium report for EPN2 (19118928 - 19240028 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for EPN2
         9 CNVs: 30808 4994 4025 72814 35442 7145 88374 35443 77543

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    Disorders / Diseases
    for EPN2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    EPN2 for disorders           About MalaCards

    EPN2 for disorders           About GeneDecksing

    OMIM gene information: 607263    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: EPN2 (1 document)

    Export disorders for EPN2 gene to outside databases

    Publications
    for EPN2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EPN2 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with EPN2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module. (PubMed id 10567358)1, 2, 3, 9 Rosenthal J.A.... De Camilli P. (1999)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
    4. Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)
    5. Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (2012)
    6. Interactome mapping suggests new mechanistic details u nderlying Alzheimer's disease. (PubMed id 21163940)1 Soler-Lopez M....Aloy P. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    10. Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays. (PubMed id 19285159)1 Fenner B.J....Prehn J.H. (2009)

    External Searches for EPN2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing EPN2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22905 HGNC: 18639 AceView: EPN2 Ensembl:ENSG00000072134 euGenes: HUgn22905
    ECgene: EPN2 Kegg: 22905 H-InvDB: EPN2

    Other Databases showing EPN2 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1065

    Specialized Databases showing EPN2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EPN2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for EPN2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for EPN2 gene:
    Search GeneIP for patents involving EPN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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