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Aliases for EPN2 Gene

Aliases for EPN2 Gene

  • Epsin 2 2 3
  • EPS-15-Interacting Protein 2 3 4
  • Eps15 Binding Protein 2 3
  • KIAA1065 4 6
  • Epsin-2 3
  • EHB21 3

External Ids for EPN2 Gene

Summaries for EPN2 Gene

Entrez Gene Summary for EPN2 Gene

  • This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for EPN2 Gene

EPN2 (Epsin 2) is a Protein Coding gene. Among its related pathways are PAK Pathway and Endocytosis. GO annotations related to this gene include lipid binding. An important paralog of this gene is EPN3.

UniProtKB/Swiss-Prot for EPN2 Gene

  • Plays a role in the formation of clathrin-coated invaginations and endocytosis.

Gene Wiki entry for EPN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPN2 Gene

Genomics for EPN2 Gene

Genomic Location for EPN2 Gene

19,215,615 bp from pter
19,336,715 bp from pter
121,101 bases
Plus strand

Genomic View for EPN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EPN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPN2 Gene

Regulatory Elements for EPN2 Gene

Proteins for EPN2 Gene

  • Protein details for EPN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8MTV8
    • B3KRX8
    • E9PBC2
    • O95207
    • Q52LD0
    • Q9H7Z2
    • Q9UPT7

    Protein attributes for EPN2 Gene

    641 amino acids
    Molecular mass:
    68482 Da
    Quaternary structure:
    • Binds EPS15 (By similarity). Binds AP-2 and clathrin.
    • Sequence=BAA83017.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG52540.1; Type=Erroneous termination; Positions=324; Note=Translated as Glu.; Evidence={ECO:0000305};

    Alternative splice isoforms for EPN2 Gene


neXtProt entry for EPN2 Gene

Proteomics data for EPN2 Gene at MOPED

Post-translational modifications for EPN2 Gene

No data available for DME Specific Peptides for EPN2 Gene

Domains for EPN2 Gene


  • The NPF repeat domain is involved in EPS15 binding:
    • O95208
  • The DPW repeat domain is involved in AP-2 and clathrin binding:
    • O95208
  • Contains 1 ENTH (epsin N-terminal homology) domain.:
    • O95208
  • Contains 2 UIM (ubiquitin-interacting motif) domains.:
    • O95208
  • Belongs to the epsin family.:
    • O95208
genes like me logo Genes that share domains with EPN2: view

No data available for Gene Families for EPN2 Gene

Function for EPN2 Gene

Molecular function for EPN2 Gene

UniProtKB/Swiss-Prot Function: Plays a role in the formation of clathrin-coated invaginations and endocytosis.

Gene Ontology (GO) - Molecular Function for EPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005543 phospholipid binding --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with EPN2: view
genes like me logo Genes that share phenotypes with EPN2: view

Animal Models for EPN2 Gene

MGI Knock Outs for EPN2:

miRNA for EPN2 Gene

miRTarBase miRNAs that target EPN2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for EPN2 Gene

Localization for EPN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPN2 Gene

Cytoplasm. Cytoplasmic vesicle, clathrin-coated vesicle. Note=In punctate structures throughout the cell, associated with clathrin-coated vesicles, and particularly concentrated in the region of the Golgi complex.

Subcellular locations from

Jensen Localization Image for EPN2 Gene COMPARTMENTS Subcellular localization image for EPN2 gene
Compartment Confidence
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for EPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0030128 clathrin coat of endocytic vesicle IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with EPN2: view

Pathways for EPN2 Gene

genes like me logo Genes that share pathways with EPN2: view

Pathways by source for EPN2 Gene

Gene Ontology (GO) - Biological Process for EPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006897 endocytosis IEA --
GO:0007219 Notch signaling pathway IEA --
GO:0048568 embryonic organ development IEA --
genes like me logo Genes that share ontologies with EPN2: view

Transcripts for EPN2 Gene

Unigene Clusters for EPN2 Gene

Epsin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EPN2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^ 18a ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - - - - - - - - -
SP5: - - -
SP6: - -
SP7: - - -
SP8: - - -
SP9: - -
SP10: - - -
SP11: - - - - - - - - - - - - - - -
SP12: - - -

ExUns: 18b ^ 19a · 19b
SP11: -

Relevant External Links for EPN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EPN2 Gene

mRNA expression in normal human tissues for EPN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for EPN2 Gene

SOURCE GeneReport for Unigene cluster for EPN2 Gene Hs.743983

mRNA Expression by UniProt/SwissProt for EPN2 Gene

Tissue specificity: Highest expression is found in brain. Detected at lower levels in lung and liver.
genes like me logo Genes that share expressions with EPN2: view

Orthologs for EPN2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EPN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EPN2 36
  • 99.17 (n)
  • 99.69 (a)
EPN2 37
  • 100 (a)
(Bos Taurus)
Mammalia EPN2 36
  • 85.06 (n)
  • 87.15 (a)
EPN2 37
  • 87 (a)
(Canis familiaris)
Mammalia EPN2 36
  • 88.65 (n)
  • 91.72 (a)
EPN2 37
  • 92 (a)
(Mus musculus)
Mammalia Epn2 36
  • 86.75 (n)
  • 89.75 (a)
Epn2 16
Epn2 37
  • 89 (a)
(Monodelphis domestica)
Mammalia EPN2 37
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia EPN2 37
  • 79 (a)
(Rattus norvegicus)
Mammalia Epn2 36
  • 86.7 (n)
  • 89.91 (a)
(Anolis carolinensis)
Reptilia EPN2 37
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5290 36
(Danio rerio)
Actinopterygii epn2 37
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta lqf 37
  • 30 (a)
(Caenorhabditis elegans)
Secernentea epn-1 37
  • 45 (a)
T04C10.2b 38
  • 37 (a)
T04C10.2a 38
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENT3 37
  • 27 (a)
ENT3 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 42 (a)
Species with no ortholog for EPN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EPN2 Gene

Gene Tree for EPN2 (if available)
Gene Tree for EPN2 (if available)

Paralogs for EPN2 Gene

Paralogs for EPN2 Gene Pseudogenes for EPN2 Gene

genes like me logo Genes that share paralogs with EPN2: view

Variants for EPN2 Gene

Sequence variations from dbSNP and Humsavar for EPN2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs754450 -- 19,312,505(+) GTCAG(C/T)CCTGT intron-variant
rs754451 -- 19,312,616(+) GGCCC(C/T)GGGGC intron-variant
rs868698 -- 19,281,898(+) ACTGT(G/T)GCCTT intron-variant, upstream-variant-2KB
rs950953 -- 19,252,466(+) AGCTT(C/T)AACAG intron-variant
rs950954 -- 19,252,535(+) ATTGG(A/C)AAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EPN2 Gene

Variant ID Type Subtype PubMed ID
nsv9504 CNV Gain+Loss 18304495
nsv833391 CNV Loss 17160897
esv33572 CNV Gain 17666407
nsv428336 CNV Gain+Loss 18775914
dgv933e1 CNV Complex 17122850
esv25927 CNV Gain+Loss 19812545
nsv2001 CNV Loss 18451855
dgv3095n71 CNV Gain 21882294
nsv833393 CNV Gain+Loss 17160897
esv2665186 CNV Deletion 23128226
esv2715728 CNV Deletion 23290073
esv2715730 CNV Deletion 23290073
esv271226 CNV Insertion 20981092

Relevant External Links for EPN2 Gene

HapMap Linkage Disequilibrium report

Disorders for EPN2 Gene

Relevant External Links for EPN2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with EPN2: view

No data available for UniProtKB/Swiss-Prot for EPN2 Gene

Publications for EPN2 Gene

  1. The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module. (PMID: 10567358) Rosenthal J.A. … De Camilli P. (J. Biol. Chem. 1999) 2 3 4 23
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for EPN2 Gene

  • Addgene plasmids for EPN2

Sources for EPN2 Gene

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