Aliases for EPN1 Gene
External Ids for EPN1 Gene
Previous GeneCards Identifiers for EPN1 Gene
This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types. [provided by RefSeq, Mar 2016]
GeneCards Summary for EPN1 Gene
EPN1 (Epsin 1) is a Protein Coding gene. Diseases associated with EPN1 include Erythrocytosis, Somatic. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Notch signaling pathway (KEGG). GO annotations related to this gene include transcription factor binding and phospholipid binding. An important paralog of this gene is EPN2.
UniProtKB/Swiss-Prot for EPN1 Gene
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.