Aliases for EPN1 Gene
External Ids for EPN1 Gene
Previous GeneCards Identifiers for EPN1 Gene
This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types. [provided by RefSeq, Mar 2016]
GeneCards Summary for EPN1 Gene
EPN1 (Epsin 1) is a Protein Coding gene. Among its related pathways are Endocytosis and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. GO annotations related to this gene include transcription factor binding and phospholipid binding. An important paralog of this gene is EPN3.
UniProtKB/Swiss-Prot for EPN1 Gene
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.