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Aliases for EPHX4 Gene

Aliases for EPHX4 Gene

  • Epoxide Hydrolase 4 2 3 5
  • Abhydrolase Domain-Containing Protein 7 3 4
  • Epoxide Hydrolase-Related Protein 3 4
  • Abhydrolase Domain Containing 7 2 3
  • EPHXRP 3 4
  • ABHD7 3 4
  • EC 3.3.-.- 4
  • EH4 3

External Ids for EPHX4 Gene

Previous HGNC Symbols for EPHX4 Gene

  • ABHD7

Previous GeneCards Identifiers for EPHX4 Gene

  • GC01P092268
  • GC01P092495
  • GC01P090615

Summaries for EPHX4 Gene

GeneCards Summary for EPHX4 Gene

EPHX4 (Epoxide Hydrolase 4) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is EPHX3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHX4 Gene

Genomics for EPHX4 Gene

Regulatory Elements for EPHX4 Gene

Enhancers for EPHX4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EPHX4 on UCSC Golden Path with GeneCards custom track

Promoters for EPHX4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EPHX4 on UCSC Golden Path with GeneCards custom track

Genomic Location for EPHX4 Gene

92,029,976 bp from pter
92,063,536 bp from pter
33,561 bases
Plus strand

Genomic View for EPHX4 Gene

Genes around EPHX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPHX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPHX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPHX4 Gene

Proteins for EPHX4 Gene

  • Protein details for EPHX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Epoxide hydrolase 4
    Protein Accession:
    Secondary Accessions:
    • Q8NCC6

    Protein attributes for EPHX4 Gene

    362 amino acids
    Molecular mass:
    42324 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EPHX4 Gene

Proteomics data for EPHX4 Gene at MOPED

Post-translational modifications for EPHX4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EPHX4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EPHX4 Gene

Domains & Families for EPHX4 Gene

Gene Families for EPHX4 Gene

Suggested Antigen Peptide Sequences for EPHX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.
  • Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.
genes like me logo Genes that share domains with EPHX4: view

Function for EPHX4 Gene

Enzyme Numbers (IUBMB) for EPHX4 Gene

genes like me logo Genes that share phenotypes with EPHX4: view

Animal Model Products

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EPHX4 Gene

Localization for EPHX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHX4 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for EPHX4 Gene COMPARTMENTS Subcellular localization image for EPHX4 gene
Compartment Confidence
mitochondrion 3
cytosol 2
golgi apparatus 2
extracellular 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for EPHX4 Gene

Pathways & Interactions for EPHX4 Gene

SuperPathways for EPHX4 Gene

No Data Available

Interacting Proteins for EPHX4 Gene

Gene Ontology (GO) - Biological Process for EPHX4 Gene


No data available for Pathways by source and SIGNOR curated interactions for EPHX4 Gene

Drugs & Compounds for EPHX4 Gene

No Compound Related Data Available

Transcripts for EPHX4 Gene

mRNA/cDNA for EPHX4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EPHX4 Gene

Epoxide hydrolase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EPHX4 Gene

No ASD Table

Relevant External Links for EPHX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EPHX4 Gene

mRNA expression in normal human tissues for EPHX4 Gene

mRNA differential expression in normal tissues according to GTEx for EPHX4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x8.0), Brain - Cortex (x7.2), Brain - Putamen (basal ganglia) (x6.1), Brain - Nucleus accumbens (basal ganglia) (x5.9), Brain - Anterior cingulate cortex (BA24) (x5.7), and Brain - Caudate (basal ganglia) (x4.8).

Protein differential expression in normal tissues from HIPED for EPHX4 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for EPHX4 Gene

SOURCE GeneReport for Unigene cluster for EPHX4 Gene Hs.201555

genes like me logo Genes that share expression patterns with EPHX4: view

Protein tissue co-expression partners for EPHX4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for EPHX4 Gene

Orthologs for EPHX4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EPHX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EPHX4 35
  • 93.37 (n)
  • 92.82 (a)
ABHD7 36
  • 93 (a)
(Canis familiaris)
Mammalia EPHX4 35
  • 94.76 (n)
  • 95.1 (a)
EPHX4 36
  • 94 (a)
(Mus musculus)
Mammalia Ephx4 35
  • 87.12 (n)
  • 89.49 (a)
Ephx4 16
Ephx4 36
  • 88 (a)
(Pan troglodytes)
Mammalia EPHX4 35
  • 99.72 (n)
  • 99.45 (a)
EPHX4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ephx4 35
  • 85.41 (n)
  • 89.81 (a)
(Monodelphis domestica)
Mammalia EPHX4 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia EPHX4 36
  • 87 (a)
(Gallus gallus)
Aves EPHX4 35
  • 80.3 (n)
  • 83.24 (a)
EPHX4 36
  • 81 (a)
(Anolis carolinensis)
Reptilia EPHX4 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ephx4 35
  • 74.34 (n)
  • 75.51 (a)
(Danio rerio)
Actinopterygii ephx4 35
  • 67.14 (n)
  • 67.61 (a)
ephx4 36
  • 66 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011972 35
  • 47.01 (n)
  • 35.56 (a)
(Caenorhabditis elegans)
Secernentea ceeh-1 35
  • 52.46 (n)
  • 43.96 (a)
ceeh-1 36
  • 33 (a)
ceeh-2 36
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
Species with no ortholog for EPHX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EPHX4 Gene

Gene Tree for EPHX4 (if available)
Gene Tree for EPHX4 (if available)

Paralogs for EPHX4 Gene

Paralogs for EPHX4 Gene

(2) SIMAP similar genes for EPHX4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EPHX4: view

Variants for EPHX4 Gene

Sequence variations from dbSNP and Humsavar for EPHX4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs17854127 - 92,063,159(+) GATTT(A/T)TGTTA reference, missense
rs1014415 -- 92,036,503(+) GATGT(A/G)TCCAA intron-variant
rs1023038 -- 92,044,297(-) TAATT(A/G)TTCAA intron-variant
rs1023039 -- 92,044,209(-) TTTTT(C/T)TCCCC intron-variant
rs1023040 -- 92,043,856(-) GCTCA(A/C)CCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EPHX4 Gene

Variant ID Type Subtype PubMed ID
esv2714684 CNV Deletion 23290073
nsv462517 CNV Gain 19166990
nsv524845 CNV Gain 19592680
nsv830581 CNV Loss 17160897
dgv264n71 CNV Gain 21882294
esv2750842 CNV Gain 17911159
nsv871606 CNV Loss 21882294
nsv871508 CNV Gain 21882294
nsv1855 CNV Insertion 18451855

Variation tolerance for EPHX4 Gene

Residual Variation Intolerance Score: 34.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 18.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EPHX4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPHX4 Gene

Disorders for EPHX4 Gene

Relevant External Links for EPHX4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for EPHX4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EPHX4 Gene

Publications for EPHX4 Gene

  1. Oxidative damage to biological macromolecules in Prague bus drivers and garagemen: impact of air pollution and genetic polymorphisms. (PMID: 20723587) Bagryantseva Y. … Sram R.J. (Toxicol. Lett. 2010) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. (PMID: 22798687) Decker M. … Arand M. (J. Lipid Res. 2012) 3
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3

Products for EPHX4 Gene

Sources for EPHX4 Gene