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Aliases for EPHX3 Gene

Aliases for EPHX3 Gene

  • Epoxide Hydrolase 3 2 3 5
  • Abhydrolase Domain-Containing Protein 9 3 4
  • Abhydrolase Domain Containing 9 2 3
  • ABHD9 3 4
  • EH3 3 4
  • EC 3.3.2.10 4

External Ids for EPHX3 Gene

Previous HGNC Symbols for EPHX3 Gene

  • ABHD9

Previous GeneCards Identifiers for EPHX3 Gene

  • GC19M015199
  • GC19M015337
  • GC19M014905

Summaries for EPHX3 Gene

GeneCards Summary for EPHX3 Gene

EPHX3 (Epoxide Hydrolase 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is EPHX4.

UniProtKB/Swiss-Prot for EPHX3 Gene

  • Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against epoxyeicosatrienoic acids (EETs) including 8,9-EET, 9,10-EET, 11,12-EET and 14,15-EET and leukotoxin.

Additional gene information for EPHX3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHX3 Gene

Genomics for EPHX3 Gene

GeneHancer (GH) Regulatory Elements for EPHX3 Gene

Promoters and enhancers for EPHX3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I015232 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.8 +0.2 152 1.1 SP1 PKNOX1 POLR2A SCRT2 SIN3A DPF2 SPI1 EZH2 EPHX3 ENSG00000269635 GC19M015202
GH19I015231 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 550.8 +1.3 1274 1.1 CTCF POLR2A ZBTB48 ZNF143 SIN3A EZH2 EPHX3 ENSG00000269635 GC19M015202
GH19I015194 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.9 +35.3 35296 6.5 HDGF PKNOX1 ZNF133 NEUROD1 SIN3A ZNF2 ZBTB7B GLIS2 KLF7 FOS NOTCH3 AKAP8 BRD4 EPHX3 RNU6-782P ZNF333 TPM4 OR7C1 MIR6795 GC19M015202
GH19I015279 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 11.3 -48.9 -48925 6.1 PKNOX1 ATF1 FOXA2 YY1 ZNF121 FOS ATF7 RXRA REST NFIL3 BRD4 AKAP8 DDX39A EPHX3 AKAP8L RNU6-782P GC19P015278 GC19P015283 GC19P015284 GC19P015285
GH19I015295 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.6 -65.3 -65284 5.8 FOXA2 MLX ARNT ARID4B FEZF1 ZNF2 SLC30A9 ZNF766 SP5 ZHX2 AKAP8 ZNF333 BRD4 EPHX3 NOTCH3 RASAL3 ENSG00000268189 SNRPGP15 RNU6-782P CYP4F24P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EPHX3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EPHX3 gene promoter:

Genomic Locations for EPHX3 Gene

Genomic Locations for EPHX3 Gene
chr19:15,226,919-15,233,435
(GRCh38/hg38)
Size:
6,517 bases
Orientation:
Minus strand
chr19:15,337,730-15,344,246
(GRCh37/hg19)

Genomic View for EPHX3 Gene

Genes around EPHX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPHX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPHX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPHX3 Gene

Proteins for EPHX3 Gene

  • Protein details for EPHX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6B9-EPHX3_HUMAN
    Recommended name:
    Epoxide hydrolase 3
    Protein Accession:
    Q9H6B9
    Secondary Accessions:
    • A3KMR3

    Protein attributes for EPHX3 Gene

    Size:
    360 amino acids
    Molecular mass:
    40909 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EPHX3 Gene

Post-translational modifications for EPHX3 Gene

Other Protein References for EPHX3 Gene

No data available for DME Specific Peptides for EPHX3 Gene

Domains & Families for EPHX3 Gene

Gene Families for EPHX3 Gene

Suggested Antigen Peptide Sequences for EPHX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6B9

UniProtKB/Swiss-Prot:

EPHX3_HUMAN :
  • Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.
Family:
  • Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.
genes like me logo Genes that share domains with EPHX3: view

Function for EPHX3 Gene

Molecular function for EPHX3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=30 uM for 8,9-EET {ECO:0000269 PubMed:22798687}; KM=80 uM for 11,12-EET {ECO:0000269 PubMed:22798687}; KM=130 uM for 14,15-EET {ECO:0000269 PubMed:22798687}; KM=25 uM for leukotoxin {ECO:0000269 PubMed:22798687}; Vmax=12 umol/min/mg enzyme with 8,9-EET as substrate {ECO:0000269 PubMed:22798687}; Vmax=50 umol/min/mg enzyme with 11,12-EET as substrate {ECO:0000269 PubMed:22798687}; Vmax=60 umol/min/mg enzyme with 14,15-EET as substrate {ECO:0000269 PubMed:22798687}; Vmax=22 umol/min/mg enzyme with leukotoxin as substrate {ECO:0000269 PubMed:22798687};
UniProtKB/Swiss-Prot CatalyticActivity:
An epoxide + H(2)O = a glycol.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by 1-(1-acetylpiperidin-4-yl)-3-(4-(trifl uoromethoxy)phenyl)urea (TPAU), 1-cyclohexyl-3-dodecylurea (CDU), 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA), 1-((3S, 5S, 7S)-adamantan-1-yl)-3-(5-(2-(2-ethoxyethoxy) ethoxy)pentyl)urea (AEPU) and to a lesser extent by 8-(3-((3S, 5S, 7S)-adamantan-1-yl)ureido) octanoic acid (AUOA).
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against epoxyeicosatrienoic acids (EETs) including 8,9-EET, 9,10-EET, 11,12-EET and 14,15-EET and leukotoxin.

Enzyme Numbers (IUBMB) for EPHX3 Gene

Phenotypes From GWAS Catalog for EPHX3 Gene

Gene Ontology (GO) - Molecular Function for EPHX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004301 epoxide hydrolase activity IMP 22798687
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with EPHX3: view
genes like me logo Genes that share phenotypes with EPHX3: view

Animal Models for EPHX3 Gene

MGI Knock Outs for EPHX3:

Animal Model Products

CRISPR Products

miRNA for EPHX3 Gene

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EPHX3 Gene

Localization for EPHX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHX3 Gene

Microsome membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EPHX3 gene
Compartment Confidence
endoplasmic reticulum 3
mitochondrion 2
plasma membrane 1
extracellular 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for EPHX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0016020 membrane IDA 22798687
GO:0016021 integral component of membrane IEA --
GO:0031090 organelle membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA,IEA 22798687
genes like me logo Genes that share ontologies with EPHX3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for EPHX3 Gene

Pathways & Interactions for EPHX3 Gene

SuperPathways for EPHX3 Gene

No Data Available

Interacting Proteins for EPHX3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000221730%0d%0a9606.ENSP00000379865%0d%0a
Selected Interacting proteins: Q9H6B9-EPHX3_HUMAN ENSP00000221730 for EPHX3 Gene via IID STRING

Gene Ontology (GO) - Biological Process for EPHX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0097176 epoxide metabolic process IDA 22798687
genes like me logo Genes that share ontologies with EPHX3: view

No data available for Pathways by source and SIGNOR curated interactions for EPHX3 Gene

Drugs & Compounds for EPHX3 Gene

No Compound Related Data Available

Transcripts for EPHX3 Gene

Unigene Clusters for EPHX3 Gene

Epoxide hydrolase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for EPHX3 Gene

No ASD Table

Relevant External Links for EPHX3 Gene

GeneLoc Exon Structure for
EPHX3
ECgene alternative splicing isoforms for
EPHX3

Expression for EPHX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EPHX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EPHX3 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x13.1), Esophagus - Mucosa (x12.6), Skin - Not Sun Exposed (Suprapubic) (x11.7), and Vagina (x5.4).

Protein differential expression in normal tissues from HIPED for EPHX3 Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EPHX3 Gene



Protein tissue co-expression partners for EPHX3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EPHX3 Gene:

EPHX3

SOURCE GeneReport for Unigene cluster for EPHX3 Gene:

Hs.156457

Evidence on tissue expression from TISSUES for EPHX3 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with EPHX3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EPHX3 Gene

Orthologs for EPHX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for EPHX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EPHX3 33 34
  • 99.44 (n)
cow
(Bos Taurus)
Mammalia EPHX3 34 33
  • 86.3 (n)
OneToOne
dog
(Canis familiaris)
Mammalia EPHX3 34
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ephx3 33 16 34
  • 80.78 (n)
rat
(Rattus norvegicus)
Mammalia Ephx3 33
  • 80.07 (n)
oppossum
(Monodelphis domestica)
Mammalia EPHX3 34
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EPHX3 34
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EPHX3 34
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii AL954361.1 34
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ceeh-1 34
  • 29 (a)
ManyToMany
ceeh-2 34
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
OneToMany
Species where no ortholog for EPHX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for EPHX3 Gene

ENSEMBL:
Gene Tree for EPHX3 (if available)
TreeFam:
Gene Tree for EPHX3 (if available)

Paralogs for EPHX3 Gene

Paralogs for EPHX3 Gene

(1) SIMAP similar genes for EPHX3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with EPHX3: view

Variants for EPHX3 Gene

Sequence variations from dbSNP and Humsavar for EPHX3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000431304 -- 15,233,421(-) G/A upstream_transcript_variant
rs1000499144 -- 15,230,816(-) G/A intron_variant
rs1001268775 -- 15,232,931(-) G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001421351 -- 15,226,500(-) G/A downstream_transcript_variant
rs1001641633 -- 15,232,524(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for EPHX3 Gene

Variant ID Type Subtype PubMed ID
dgv3442n100 CNV loss 25217958
esv34154 CNV loss 18971310
nsv578717 CNV loss 21841781
nsv953983 CNV deletion 24416366

Variation tolerance for EPHX3 Gene

Residual Variation Intolerance Score: 83.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EPHX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EPHX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPHX3 Gene

Disorders for EPHX3 Gene

Additional Disease Information for EPHX3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for EPHX3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EPHX3 Gene

Publications for EPHX3 Gene

  1. EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. (PMID: 22798687) Decker M … Arand M (Journal of lipid research 2012) 3 4 58
  2. Oxidative damage to biological macromolecules in Prague bus drivers and garagemen: impact of air pollution and genetic polymorphisms. (PMID: 20723587) Bagryantseva Y … Sram RJ (Toxicology letters 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Validation study of genes with hypermethylated promoter regions associated with prostate cancer recurrence. (PMID: 24718283) Stott-Miller M … Stanford JL (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2014) 3 58

Products for EPHX3 Gene

Sources for EPHX3 Gene

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