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Aliases for EPHX3 Gene

Aliases for EPHX3 Gene

  • Epoxide Hydrolase 3 2 3 5
  • Abhydrolase Domain-Containing Protein 9 3 4
  • Abhydrolase Domain Containing 9 2 3
  • ABHD9 3 4
  • EC 3.3.-.- 4
  • EH3 3

External Ids for EPHX3 Gene

Previous HGNC Symbols for EPHX3 Gene

  • ABHD9

Previous GeneCards Identifiers for EPHX3 Gene

  • GC19M015199
  • GC19M015337
  • GC19M014905

Summaries for EPHX3 Gene

GeneCards Summary for EPHX3 Gene

EPHX3 (Epoxide Hydrolase 3) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is EPHX4.

Additional gene information for EPHX3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHX3 Gene

Genomics for EPHX3 Gene

Regulatory Elements for EPHX3 Gene

Enhancers for EPHX3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H015295 1.6 Ensembl ENCODE dbSUPER 11.5 -65.3 -65285 5.8 FOXA2 MLX ARNT ARID4B FEZF1 ZNF2 SLC30A9 ZNF766 SP5 ZHX2 AKAP8 ZNF333 BRD4 EPHX3 NOTCH3 RASAL3 ENSG00000268189 SNRPGP15 RNU6-782P CYP4F24P
GH19H015194 1.5 Ensembl ENCODE dbSUPER 12.2 +35.3 35340 6.4 HDGF PKNOX1 ZNF133 SIN3A ZNF2 ZBTB7B GLIS2 FOS KLF7 SP3 AKAP8 BRD4 EPHX3 RNU6-782P ZNF333 TPM4 NOTCH3 MIR6795
GH19H015279 1.5 Ensembl ENCODE dbSUPER 11.3 -48.9 -48925 6.1 PKNOX1 ATF1 FOXA2 YY1 ZNF121 FOS ATF7 REST NFIL3 SSRP1 AKAP8 DDX39A BRD4 EPHX3 AKAP8L RNU6-782P GC19P015285 GC19M015286
GH19H015316 1.4 Ensembl ENCODE dbSUPER 11.3 -86.0 -85956 6.4 HDAC1 HDGF NFRKB ZEB1 ZNF121 ZNF366 SCRT2 RCOR1 ATF7 RUNX3 AKAP8 DDX39A BRD4 NOTCH3 EPHX3 AKAP8L RAB8A GC19P015309
GH19H015285 1.3 Ensembl ENCODE dbSUPER 11.2 -54.6 -54592 4.7 HDGF MAX ZIC2 ZFHX2 POLR2A EED PATZ1 ZNF600 PRDM10 RUNX3 BRD4 AKAP8 EPHX3 AKAP8L RNU6-782P GC19M015286 GC19P015285
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EPHX3 on UCSC Golden Path with GeneCards custom track

Promoters for EPHX3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107620 35 401 PKNOX1 POLR2A SCRT2 DPF2 SPI1

Genomic Locations for EPHX3 Gene

Genomic Locations for EPHX3 Gene
6,517 bases
Minus strand

Genomic View for EPHX3 Gene

Genes around EPHX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPHX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPHX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPHX3 Gene

Proteins for EPHX3 Gene

  • Protein details for EPHX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Epoxide hydrolase 3
    Protein Accession:
    Secondary Accessions:
    • A3KMR3

    Protein attributes for EPHX3 Gene

    360 amino acids
    Molecular mass:
    40909 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EPHX3 Gene

Post-translational modifications for EPHX3 Gene

  • Glycosylation at isoforms=267
  • Modification sites at PhosphoSitePlus

Other Protein References for EPHX3 Gene

No data available for DME Specific Peptides for EPHX3 Gene

Domains & Families for EPHX3 Gene

Gene Families for EPHX3 Gene

Suggested Antigen Peptide Sequences for EPHX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.
  • Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.
genes like me logo Genes that share domains with EPHX3: view

Function for EPHX3 Gene

Enzyme Numbers (IUBMB) for EPHX3 Gene

Phenotypes From GWAS Catalog for EPHX3 Gene

Gene Ontology (GO) - Molecular Function for EPHX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004301 epoxide hydrolase activity IMP 22798687
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with EPHX3: view
genes like me logo Genes that share phenotypes with EPHX3: view

Animal Model Products

CRISPR Products

miRNA for EPHX3 Gene

Inhibitory RNA Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EPHX3 Gene

Localization for EPHX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHX3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EPHX3 gene
Compartment Confidence
extracellular 4
mitochondrion 2
plasma membrane 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for EPHX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0016020 membrane IDA,IEA 22798687
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA 22798687
genes like me logo Genes that share ontologies with EPHX3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for EPHX3 Gene

Pathways & Interactions for EPHX3 Gene

SuperPathways for EPHX3 Gene

No Data Available

Interacting Proteins for EPHX3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9H6B9-EPHX3_HUMAN ENSP00000221730 for EPHX3 Gene via IID STRING

Gene Ontology (GO) - Biological Process for EPHX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0097176 epoxide metabolic process IDA 22798687
genes like me logo Genes that share ontologies with EPHX3: view

No data available for Pathways by source and SIGNOR curated interactions for EPHX3 Gene

Drugs & Compounds for EPHX3 Gene

No Compound Related Data Available

Transcripts for EPHX3 Gene

Unigene Clusters for EPHX3 Gene

Epoxide hydrolase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for EPHX3 Gene

No ASD Table

Relevant External Links for EPHX3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EPHX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EPHX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EPHX3 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x13.1), Esophagus - Mucosa (x12.6), Skin - Not Sun Exposed (Suprapubic) (x11.7), and Vagina (x5.4).

Protein differential expression in normal tissues from HIPED for EPHX3 Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EPHX3 Gene

Protein tissue co-expression partners for EPHX3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EPHX3 Gene:


SOURCE GeneReport for Unigene cluster for EPHX3 Gene:


Evidence on tissue expression from TISSUES for EPHX3 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with EPHX3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EPHX3 Gene

Orthologs for EPHX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for EPHX3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EPHX3 33 34
  • 99.44 (n)
(Bos Taurus)
Mammalia EPHX3 33 34
  • 86.3 (n)
(Canis familiaris)
Mammalia EPHX3 34
  • 82 (a)
(Mus musculus)
Mammalia Ephx3 33 16 34
  • 80.78 (n)
(Rattus norvegicus)
Mammalia Ephx3 33
  • 80.07 (n)
(Monodelphis domestica)
Mammalia EPHX3 34
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia EPHX3 34
  • 61 (a)
(Anolis carolinensis)
Reptilia EPHX3 34
  • 43 (a)
(Danio rerio)
Actinopterygii AL954361.1 34
  • 40 (a)
(Caenorhabditis elegans)
Secernentea ceeh-1 34
  • 29 (a)
ceeh-2 34
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
Species where no ortholog for EPHX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for EPHX3 Gene

Gene Tree for EPHX3 (if available)
Gene Tree for EPHX3 (if available)

Paralogs for EPHX3 Gene

Paralogs for EPHX3 Gene

(1) SIMAP similar genes for EPHX3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with EPHX3: view

Variants for EPHX3 Gene

Sequence variations from dbSNP and Humsavar for EPHX3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000431304 -- 15,233,421(+) CTGTG(A/G)TTCCA upstream-variant-2KB
rs1000499144 -- 15,230,816(+) GAGGA(A/G)TTCCA intron-variant
rs1001268775 -- 15,232,931(+) GAGGG(G/T)ATCCT upstream-variant-2KB, utr-variant-5-prime
rs1001421351 -- 15,226,500(+) ACTGT(A/G)GTCGG downstream-variant-500B
rs1001641633 -- 15,232,524(+) TGCGG(A/G)GCTTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for EPHX3 Gene

Variant ID Type Subtype PubMed ID
nsv953983 CNV deletion 24416366
nsv578717 CNV loss 21841781
esv34154 CNV loss 18971310
dgv3442n100 CNV loss 25217958

Variation tolerance for EPHX3 Gene

Residual Variation Intolerance Score: 83.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EPHX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPHX3 Gene

Disorders for EPHX3 Gene

Relevant External Links for EPHX3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for EPHX3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EPHX3 Gene

Publications for EPHX3 Gene

  1. Oxidative damage to biological macromolecules in Prague bus drivers and garagemen: impact of air pollution and genetic polymorphisms. (PMID: 20723587) Bagryantseva Y … Sram RJ (Toxicology letters 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Validation study of genes with hypermethylated promoter regions associated with prostate cancer recurrence. (PMID: 24718283) Stott-Miller M … Stanford JL (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2014) 3 60
  5. EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. (PMID: 22798687) Decker M … Arand M (Journal of lipid research 2012) 3 60

Products for EPHX3 Gene

Sources for EPHX3 Gene

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