Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

EPHX2 Gene

protein-coding GIFtS: 69
GCID: GC08P027348

epoxide hydrolase 2, cytoplasmic

Explore 50 diseases affiliated with
EPHX2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Epoxide Hydrolase 2, Cytoplasmic¹ ²		Epoxide Hydratase²
CEH²		Epoxide Hydrolase 2, Cytosolic²
SEH²		Epoxide Hydrolase, Soluble²
Bifunctional Epoxide Hydrolase 2²

External Ids:	HGNC: 3402¹	Entrez Gene: 2053²	Ensembl: ENSG00000120915⁷	OMIM: 132811⁵	UniProtKB: P34913³

Export aliases for EPHX2 gene to outside databases

Previous GC identifers: GC08P027131 GC08P027853 GC08P027370 GC08P027404 GC08P025893

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EPHX2:

This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes,

binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been

associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described.

(provided by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: HYES_HUMAN, P34913

Function: Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene

oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides.

Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity,

with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by

erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid,

12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate

Gene Wiki entry for EPHX2 (Epoxide hydrolase 2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_167187.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the EPHX2 gene promoter:
GR PPAR-alpha GR-beta GR-alpha NF-kappaB NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EPHX2 promoter sequence

Search SABiosciences Chromatin IP Primers for EPHX2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPHX2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21 Ensembl cytogenetic band: 8p21.2 HGNC cytogenetic band: 8p21

EPHX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHX2 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P027348: view genomic region (about GC identifiers)

Start:	27,348,296 bp from pter	End:	27,403,081 bp from pter
Size:	54,786 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HYES_HUMAN, P34913 (See protein sequence)

Recommended Name: Bifunctional epoxide hydrolase 2

Size: 555 amino acids; 62616 Da

Cofactor: Magnesium

Subunit: Homodimer

Subcellular location: Cytoplasm. Peroxisome

6/14 PDB 3D structures from and Proteopedia for EPHX2 (see all 14):

1S8O (3D)

1VJ5 (3D)

1ZD2 (3D)

1ZD3 (3D)

1ZD4 (3D)

1ZD5 (3D)

Secondary accessions: B2Z3B1 B3KTU8 B3KUA0 G3V134 J3KPH7 Q16764 Q9HBJ1 Q9HBJ2

Alternative splicing: 3 isoforms: P34913-1 P34913-2 P34913-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EPHX2: NX_P34913

Post-translational modifications:

The N-terminus is blocked¹

The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may

occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation (Probable)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P34913

EPHX2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001243411.1 NP_001243412.1 NP_001243413.1 NP_001970.2

ENSEMBL proteins:

ENSP00000430269 ENSP00000430779 ENSP00000428875 ENSP00000430302 ENSP00000369843

ENSP00000427956 ENSP00000428191

Reactome Protein details: P34913
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: EPHX2 OriGene Protein Over-expression Lysate: EPHX2 OriGene Custom Protein Services for EPHX2
	GenScript Custom Purified and Recombinant Proteins Services for EPHX2
	Novus Biologicals EPHX2 Proteins Novus Biologicals EPHX2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for EPHX2

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005730	nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005777	peroxisome	IDA	16314446
GO:0005794	Golgi apparatus	IDA	--
GO:0005829	cytosol	NAS	10862610

EPHX2 for ontologies About GeneDecksing

EPHX2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of EPHX2
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 5): EPHX2 OriGene Custom Antibody Services for EPHX2
	GenScript Custom Superior Antibodies Services for EPHX2
	Novus Biologicals EPHX2 Antibodies
	Abcam antibodies for EPHX2
	Uscn Antibodies for EPHX2
	Search ThermoFisher Antibodies for EPHX2

Assay Products for EPHX2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for EPHX2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for EPHX2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

EPHX2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR011945 HAD-SF_ppase_IA/epoxid_hydro_N

IPR000073 AB_hydrolase_1

IPR023214 HAD-like_dom

IPR000639 Epox_hydrolase-like

IPR006402 HAD-SF_hydro_IA_v3

Graphical View of Domain Structure for InterPro Entry P34913

ProtoNet protein and cluster: P34913

4 Blocks protein families:

IPB000073 Alpha/beta hydrolase fold

IPB000639 Epoxide hydrolase signature

IPB003089 Alpha/beta hydrolase fold signature

IPB005833 Haloacid dehalogenase/epoxide hydrolase family signature

UniProtKB/Swiss-Prot: HYES_HUMAN, P34913

Domain: The N-terminal domain has phosphatase activity. The C-terminal domain has epoxide hydrolase activity

Similarity: Belongs to the AB hydrolase superfamily. Epoxide hydrolase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HYES_HUMAN, P34913

Function: Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene

oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides.

Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity,

with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by

erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid,

12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate

Catalytic activity: An epoxide + H(2)O = a glycol

Catalytic activity: (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H(2)O = (9S,10S)-9,10-dihydroxyoctadecanoate +

phosphate

Biophysicochemical properties: Kinetic parameters: KM=21 uM for threo-9,10-phosphonooxy-hydroxy-octadecanoic acid;

KM=1.1 mM for p-nitrophenyl phosphate; Vmax=338 nmol/min/mg enzyme with threo-9,10-phosphonooxy- hydroxy-octadecanoic

acid; Vmax=5.8 nmol/min/mg enzyme with p-nitrophenyl phosphate;

Induction: By compounds that cause peroxisome proliferation such as clofibrate, tiadenol and fenofibrate

Genatlas biochemistry entry for EPHX2:

epoxyde hydrolase,soluble

miRNA Products:		OriGene 3'-UTR Clone: EPHX2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EPHX2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate EPHX2:
		hsa-miR-4311
		SwitchGear 3'UTR luciferase reporter plasmid: EPHX2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EPHX2 (see all 7) OriGene shRNA RFP: EPHX2 OriGene siRNA: EPHX2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPHX2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for EPHX2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EPHX2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EPHX2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: EPHX2 (NM_001979)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHX2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHX2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for EPHX2
		Search LifeMap BioReagents cell lines for EPHX2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHX2

Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IDA	12574510
GO:0003824	catalytic activity	--	--
GO:0003869	4-nitrophenylphosphatase activity	IDA	12574508
GO:0004301	epoxide hydrolase activity	IDA	8342951
GO:0005102	receptor binding	IPI	--

EPHX2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for EPHX2:

Increased G2M DNA content

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Ephx2^tm1Gonz for EPHX2
2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ephx2):

cardiovascular system

homeostasis/metabolism

EPHX2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Arachidonic acid metabolism

	Arachidonic acid metabolism	1.00			HETE and HPETE biosynthesis and metabolism	0.39
	Arachidonic acid metabolism	0.42			HETE and HPETE biosynthesis and metabolism	0.39

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

Naphthalene metabolism

Naphthalene metabolism

1.00

Naphthalene metabolism

1.00

ATP/ITP metabolism

ATP/ITP metabolism

1.00

ATP/ITP metabolism

0.98

Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

1.00

Arachidonate Epoxygenase / Epoxide Hydrolase

0.36

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for EPHX2

	Naphthalene metabolism
	HETE and HPETE biosynthesis and metabolism
	ATP/ITP metabolism

3 GeneGo (Thomson Reuters) Pathways for EPHX2

	HETE and HPETE biosynthesis and metabolism
	Naphthalene metabolism
	ATP/ITP metabolism

2 BioSystems Pathways for EPHX2

	Arachidonate Epoxygenase / Epoxide Hydrolase
	metapathway biotransformation

4 Reactome Pathways for EPHX2

	Metabolism
	Arachidonic acid metabolism
	Metabolism of lipids and lipoproteins
	Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

3 Kegg Pathways (Kegg details for EPHX2):

	Arachidonic acid metabolism
	Metabolic pathways
	Peroxisome

EPHX2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for EPHX2

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/11 Interacting proteins for EPHX2 (P34913^{2, 3} ENSP00000369843⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NIPSNAP3A	Q9UFN0²^,³, ENSP00000363899⁴	MINT-63686 I2D: score=4 STRING: ENSP00000363899
CYP2B6	ENSP00000324648⁴	STRING: ENSP00000324648
CYP2C18	ENSP00000285979⁴	STRING: ENSP00000285979
CYP2C19	ENSP00000360372⁴	STRING: ENSP00000360372
CYP2C8	ENSP00000360317⁴	STRING: ENSP00000360317

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006805	xenobiotic metabolic process	NAS	10862610
GO:0006874	cellular calcium ion homeostasis	NAS	10862610
GO:0006954	inflammatory response	NAS	10862610
GO:0008217	regulation of blood pressure	NAS	10862610
GO:0009636	response to toxin	NAS	10862610

EPHX2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EPHX2 for compounds About GeneDecksing

EMD Millipore small molecules for EPHX2:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for EPHX2

Browse Tocris compounds for EPHX2

10/12 HMDB Compounds for EPHX2 (see all 12) About this table

Compound	Synonyms	CAS #	PubMed Ids
11,12-DiHETrE	11,12-Dihydroxyeicosatrienoic acid (see all 13)	192461-95-3	--
11,12-Epoxyeicosatrienoic acid	10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)	81276-02-0	--
14,15-DiHETrE	14,15-dihydroxy-5Z,8Z,11Z-eicosatrienoic acid (see all 10)	77667-09-5	--
14,15-Epoxy-5,8,11-eicosatrienoic acid	(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)	81276-03-1	--
15-Epi-lipoxin A4	15-epi-LXA(,4) (see all 7)	--	--
15-Epi-lipoxin B5	5(S),14(R),15(S)-trihydroxy-6E,8Z,10E,12E,17Z-eicosapentaenoic acid anion (see all 3)	--	--
5,6-DHET	5,6-DiHETrE (see all 9)	213382-49-1	--
5,6-Epoxy-8,11,14-eicosatrienoic acid	5,6-epoxy-8Z,11Z,14Z-eicosatrienoic acid (see all 9)	81246-84-6	--
8,9-DiHETrE	(5Z,11Z,14Z)-8,9-Dihydroxyicosa-5,11,14-trienoic acid (see all 10)	192461-96-4	--
8,9-Epoxyeicosatrienoic acid	8,9-epoxy-5Z,11Z,14Z-eicosatrienoic acid (see all 10)	81246-85-7	--

7 DrugBank Compounds for EPHX2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
N-Cyclohexyl-N'-(4-Iodophenyl)Urea	--	--	target	--	17139284 17016423 10592235
4-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}BUTANOIC ACID	--	--	target	--	10592235
6-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEXANOIC ACID	--	--	target	--	10592235
7-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEPTANOIC ACID	--	--	target	--	10592235
N-Cyclohexyl-N'-(Propyl)Phenyl Urea	--	--	target	--	10592235
N-Cyclohexyl-N'-Decylurea	--	--	target	--	10592235
N-[(CYCLOHEXYLAMINO)CARBONYL]GLYCINE	--	--	target	--	10592235

10/82 Novoseek chemical compound relationships for EPHX2 gene (see all 82) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
epoxide	98.7	1098	14665429 (9), 9635886 (8), 1958232 (7), 19671760 (7) (see all 99)
cis-stilbene oxide	85	2	2272333 (1), 1936901 (1)
tcpo	80.9	8	8240407 (1), 8961944 (1), 10426800 (1), 11397396 (1) (see all 6)
3-butene-1,2-diol	80.8	1	9280411 (1)
styrene oxide	80.1	19	8452475 (2), 7818768 (2), 8314768 (1), 7694107 (1) (see all 12)
benzo(a)pyrene 4,5-oxide	79.6	1	8314768 (1)
butadiene monoxide	78	16	9280411 (3), 1638680 (2), 9016811 (1), 8070886 (1) (see all 8)
(2,3-epoxypropyl)benzene	77.2	1	8886614 (1)
benzeneoxide	73.8	1	8723729 (1)
valpromide	73.5	4	8877250 (1), 1352988 (1), 8156045 (1), 8453849 (1)

Search CenterWatch for drugs/clinical trials and news about EPHX2 / HYES

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for EPHX2 gene (4 alternative transcripts):

NM_001256482.1 NM_001256483.1 NM_001256484.1 NM_001979.5

Unigene Cluster for EPHX2:

Epoxide hydrolase 2, cytoplasmic

Hs.212088 [show with all ESTs]

Unigene Representative Sequence: NM_001979

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000521400(uc003xfu.3 uc010luv.3 uc003xfv.3 uc010luw.3)

ENST00000518328 ENST00000520623(uc011lam.1 uc010lut.1) ENST00000517536

ENST00000521780 ENST00000380476 ENST00000518379 ENST00000520666 ENST00000521684

ENST00000523827 ENST00000521924 ENST00000523326

miRNA Products:		OriGene 3'-UTR Clone: EPHX2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EPHX2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate EPHX2:
		hsa-miR-4311
		SwitchGear 3'UTR luciferase reporter plasmid: EPHX2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EPHX2 (see all 7) OriGene shRNA RFP: EPHX2 OriGene siRNA: EPHX2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPHX2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EPHX2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EPHX2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: EPHX2 (NM_001979)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHX2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHX2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EPHX2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat EPHX2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPHX2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPHX2

Additional cDNA sequence:

AF233334.1 AF233335.1 AF233336.1 AK096089.1 AK096770.1 AK294065.1 AK303904.1 AK308041.1

AK310507.1 BC007708.2 BC011628.2 BC013874.2 BT006885.1 L05779.1

17 DOTS entries:

DT.75103390 DT.100809993 DT.315914 DT.100806588 DT.100809998 DT.100809988 DT.101978938 DT.100809987

DT.315917 DT.120636852 DT.91744851 DT.100765345 DT.100809991 DT.120636795 DT.120636851 DT.91744853

DT.75132055

24/279 AceView cDNA sequences (see all 279):

CR590835 R01942 BT006885 AK096089 BM756809 AW271666 AF233334 AW173361

BF330315 AU122049 N26807 AW665862 BM702969 CA394497 BQ267755 BX642653

BC011628 CB121777 NM_001979 AI245624 BI771523 AA300747 CB137687 BU729448

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for EPHX2 (see all 11) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^
SP1:											-												-										-
SP2:											-		-		-								-										-
SP3:											-		-										-										-
SP4:											-												-										-		-
SP5:			-		-						-

ExUns:	18	^	19	^	20	^	21
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for EPHX2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

EPHX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGCATCGT

About this image

EPHX2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Left Ventricle

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See EPHX2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EPHX2

SOURCE GeneReport for Unigene cluster: Hs.212088

SABiosciences Expression via Pathway-Focused PCR Arrays including EPHX2 (see all 6):

Hypertension in human mouse rat

Oxidative Stress in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Drug Metabolism: Phase II Enzymes in human mouse rat

Cellular Stress Responses in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EPHX2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat EPHX2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPHX2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPHX2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHX2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for EPHX2 gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	EPHX2¹	epoxide hydrolase 2, cytoplasmic	63.04(n) 57.46(a)		421999 NM_001033645.1 NP_001028817.1
lizard (Anolis carolinensis)	Reptilia	EPHX2⁶	--	49(a)	1 ↔ 1	GL343696.1(30401-100207)
African clawed frog (Xenopus laevis)	Amphibia	Xl.18049²	Xenopus laevis transcribed sequence with weak similarity more	74.27(n)		BG884818.1
zebrafish (Danio rerio)	Actinopterygii	ephx2¹	epoxide hydrolase 2, cytoplasmic	56.22(n) 50.75(a)		494099 NM_001008642.1 NP_001008642.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G51000¹	putative epoxide hydrolase	46.86(n) 37.01(a)		824264 NM_114960.3 NP_190669.1
rice (Oryza sativa)	Liliopsida	Os12g0636400¹	hypothetical protein	46.94(n) 35.64(a)		4352891 NM_001073896.1 NP_001067364.1

ENSEMBL Gene Tree for EPHX2 (if available)
TreeFam Gene Tree for EPHX2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for EPHX2 gene

EPHX4² EPHX3²

2 SIMAP similar genes for EPHX2 using alignment to 5 protein entries: HYES_HUMAN (see all proteins):

ACAD10 EPHX4

EPHX2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs62504266^1,2	C,	--	25891600(+)	`TCAGCA/GGGCCA`	3	--	us2k¹		4	WA CSA NA	241
rs74412457^1,2		--	25891607(+)	`GCCACC/TGCTAG`	3	--	us2k¹		1	EA	120
rs6994778^1,2	C,F,A,	--	25891644(+)	`agccaA/Gggatc`	3	--	us2k¹ tfbs³		7	NA WA CSA	248
rs7003532^1,2	C,	--	25892152(+)	`actccC/Tggcct`	4	--	us2k¹		1	WA	2
rs7003694^1,2	C,F,A,H,	--	25892248(+)	`TACTAT/CATAGG`	4	--	us2k¹		22	NS EA NA WA	1970
rs11995542^1,2	C,F,H,	--	25892425(+)	`AACATC/TCGGTG`	4	--	us2k¹		28	NA NS EA WA	2338
rs72473918^1,2	C,F,	--	25892666(+)	`AGATCC/GAGAGA`	4	--	us2k¹		5	NS	190
rs7017595^1,2	C,F,H,	--	25892677(+)	`CTGTTG/TTAGAC`	4	--	us2k¹		15	NS EA NA WA	1070
rs72473919^1,2	C,	--	25892788(+)	`AAATTC/ATCCAC`	4	--	us2k¹		5	NS	188
rs72473921^1,2	C,F,	--	25892897(+)	`TTTAGT/CTTTTC`	4	--	us2k¹		7	NS CSA WA	308

HapMap Linkage Disequilibrium report for EPHX2 (27348296 - 27403081 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for EPHX2
1 CNV: 70327
Human Gene Mutation Database (HGMD): EPHX2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EPHX2

DNA2.0 Custom Variant and Variant Library Synthesis for EPHX2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

EPHX2 for disorders           About GeneDecksing

OMIM gene information: 132811
OMIM disorders: 143890
20/50 diseases for EPHX2 (see all 50):    About MalaCards

hypercholesterolemia, familial, due to ldlr defect, modifier of hypercholesterolemia familial hypercholesterolemia fetal hydantoin syndrome

pre-eclampsia non-hodgkin lymphoma hellp syndrome spontaneous abortion

orolaryngeal cancer toxic shock syndrome arterial calcification staphyloenterotoxemia

hodgkin's lymphoma coronary heart disease bronchial asthma chronic lymphocytic leukemia

lymphocytic leukemia insulin resistance mastitis eclampsia

3 diseases from the University of Copenhagen DISEASES database for EPHX2:

Staphyloenterotoxemia Toxic shock syndrome Mastitis

10/27 Novoseek disease relationships for EPHX2 gene (see all 27) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fetal hydantoin syndrome	71.5	1	8711731 (1)
inflammation	32.8	34	19519461 (2), 16962614 (2), 15196990 (1), 15963942 (1) (see all 21)
nasal epithelium	21.9	1	11551533 (1)
hellp syndrome	13.3	1	11283205 (1)
cancer lung	12.2	4	1538419 (1), 19721221 (1), 12935919 (1), 7728947 (1)
hepatocellular carcinoma	12	6	8380119 (3), 7892276 (1), 8851825 (1), 1339049 (1)
acute respiratory distress	11.4	1	17435320 (1)
cardiovascular diseases	10.2	12	16961727 (2), 18537101 (2), 16729954 (1), 20425256 (1) (see all 8)
lymphoma	4.91	2	11406608 (1), 12397416 (1)
respiratory distress syndrome	3.46	1	17435320 (1)

Genetic Association Database (GAD): EPHX2
Human Genome Epidemiology (HuGE) Navigator: EPHX2 (39 documents)

Export disorders for EPHX2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for EPHX2 gene, integrated from 9 sources (see all 408):
(articles sorted by number of sources associating them with EPHX2)

Utopia: connect your pdf to the dynamic
world of online information

Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study. (PubMed id 16595607)^{1, 4, 9} Lee C.R....Zeldin D.C. (2006)
Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis. (PubMed id 15096040)^{1, 2, 9} Gomez G.A.... Christianson D.W. (2004)
Genetic polymorphisms of microsomal and soluble epoxide hydrolase and the risk of Parkinson's disease. (PubMed id 11692079)^{1, 4, 9} Farin F.M....Checkoway H. (2001)
Identification and functional characterization of human soluble epoxide hydrolase genetic polymorphisms. (PubMed id 10862610)^{1, 2, 9} Sandberg M.... Omiecinski C.J. (2000)
Association of soluble epoxide hydrolase gene polymorphism with insulin resistance in type 2 diabetic patients. (PubMed id 15845398)^{1, 4, 9} Ohtoshi K....Yamasaki Y. (2005)
Polymorphism of the soluble epoxide hydrolase is associated with coronary artery calcification in African-American subjects: The Coronary Artery Risk Development in Young Adults (CARDIA) study. (PubMed id 14732757)^{1, 4, 9} Fornage M....Wong N.D. (2004)
Structural characterization of the human soluble epoxide hydrolase gene (EPHX2). (PubMed id 8619856)^{1, 2, 9} Sandberg M. and Meijer J. (1996)
cDNA cloning and expression of a soluble epoxide hydrolase from human liver. (PubMed id 8342951)^{1, 2, 9} Beetham J.K.... Hammock B.D. (1993)
The soluble epoxide hydrolase gene harbors sequence variation associated with susceptibility to and protection from incident ischemic stroke. (PubMed id 16115816)^{1, 4, 9} Fornage M....Boerwinkle E. (2005)
The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. (PubMed id 12574510)^{1, 2, 9} Newman J.W....Hammock B.D. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2053	HGNC: 3402	AceView: EPHX2	Ensembl:ENSG00000120915	euGenes: HUgn2053
ECgene: EPHX2	Kegg: 2053	H-InvDB: EPHX2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for EPHX2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for EPHX2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/ephx2/

Intellectual Property for EPHX2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for EPHX2 gene:
Search GeneIP for patents involving EPHX2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Purified and Recombinant Proteins at EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of EPHX2
	EMD Millipore small molecules (inhibitor) for EPHX2
	Browse Kits and Assays available from EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for EPHX2		OriGene shRNA RFP for EPHX2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EPHX2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EPHX2
	OriGene Protein Over-expression Lysate for EPHX2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for EPHX2		OriGene 3'-UTR Clone for EPHX2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EPHX2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EPHX2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for EPHX2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for EPHX2		OriGene Custom Protein Services for EPHX2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EPHX2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EPHX2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPHX2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPHX2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPHX2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPHX2

	GenScript Custom Purified and Recombinant Proteins Services for EPHX2		GenScript cDNA clones with any tag delivered in your preferred vector for EPHX2
	GenScript Custom Assay Services for EPHX2		GenScript Custom Superior Antibodies Services for EPHX2
	GenScript Custom overexpressing Cell Line Services for EPHX2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in EPHX2 promoter
	Search Chromatin IP Primers for EPHX2
	RT² qPCR Primer Assay in human, mouse, rat EPHX2
	Search GNC Networks for EPHX2
	SABiosciences PCR Arrays including human, mouse, rat EPHX2

Search Tocris compounds for EPHX2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Drugs for EPHX2
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	EPHX2 antibodies
	EPHX2 proteins
	EPHX2 lysates

	Antibodies for EPHX2
	See all of Abcam's Antibodies, Kits and Proteins for EPHX2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

EPHX2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for EPHX2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHX2

	SwitchGear 3'UTR luciferase reporter plasmids for EPHX2
	SwitchGear Promoter luciferase reporter plasmids for EPHX2

Search ThermoFisher Antibodies for EPHX2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHX2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes EPHX2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

EPHX2 Gene

epoxide hydrolase 2, cytoplasmic

Aliases
for EPHX2 gene

Summaries
for EPHX2 gene

Genomic Views
for EPHX2 gene

Proteins
for EPHX2 gene

Protein Domains /
Families
for EPHX2 gene

Function
for EPHX2 gene

Pathways & Interactions
for EPHX2 gene

Drugs & Compounds
for EPHX2 gene

Transcripts
for EPHX2 gene

Expression
for EPHX2 gene

Orthologs
for EPHX2 gene

Paralogs
for EPHX2 gene

Genomic Variants
for EPHX2 gene

Disorders / Diseases
for EPHX2 gene

Publications
for EPHX2 gene

External Searches for EPHX2 gene

Genome Databases showing EPHX2 gene

Other Databases showing EPHX2 gene

Specialized Databases showing EPHX2 gene

Intellectual Property
for EPHX2 gene

Products
for EPHX2 gene

View Random Gene

Lymphoma
LUNG TUMOR
COLON ADENOCARCINOMA
Hyperplasia
Colorectal Cancer
Adenoma
Inflammation
Carcinoma
Hepatitis
Acute respiratory distress
Atherosclerosis
Nasal Epithelium
STROKE
Liver diseases
Breast Cancer
Respiratory Distress Syndrome
Chromosomal Aberrations
Cardiovascular Diseases
HELLP Syndrome
Tumors
Fetal hydantoin syndrome
HEPATOCELLULAR CARCINOMA
Adenocarcinoma
Necrosis
Cancer
Cancer Lung
Preeclampsia

Advanced Search

Export list of displayed genes

EPHX2 Gene

epoxide hydrolase 2, cytoplasmic

Aliasesfor EPHX2 gene

Summariesfor EPHX2 gene

Genomic Viewsfor EPHX2 gene

Proteinsfor EPHX2 gene

Protein Domains /Familiesfor EPHX2 gene

Functionfor EPHX2 gene

Pathways & Interactionsfor EPHX2 gene

Drugs & Compoundsfor EPHX2 gene

Transcriptsfor EPHX2 gene

Expression for EPHX2 gene

Orthologsfor EPHX2 gene

Paralogsfor EPHX2 gene

Genomic Variantsfor EPHX2 gene

Disorders / Diseasesfor EPHX2 gene

Publicationsfor EPHX2 gene

External Searches for EPHX2 gene

Genome Databases showing EPHX2 gene

Other Databases showing EPHX2 gene

Specialized Databases showing EPHX2 gene

Intellectual Propertyfor EPHX2 gene

Productsfor EPHX2 gene

View Random Gene

Aliases
for EPHX2 gene

Summaries
for EPHX2 gene

Genomic Views
for EPHX2 gene

Proteins
for EPHX2 gene

Protein Domains /
Families
for EPHX2 gene

Function
for EPHX2 gene

Pathways & Interactions
for EPHX2 gene

Drugs & Compounds
for EPHX2 gene

Transcripts
for EPHX2 gene

Expression
for EPHX2 gene

Orthologs
for EPHX2 gene

Paralogs
for EPHX2 gene

Genomic Variants
for EPHX2 gene

Disorders / Diseases
for EPHX2 gene

Publications
for EPHX2 gene

Intellectual Property
for EPHX2 gene

Products
for EPHX2 gene