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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EPHX2 Gene

protein-coding   GIFtS: 70
GCID: GC08P027348

Epoxide Hydrolase 2, Cytoplasmic

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Epoxide Hydrolase 2, Cytoplasmic1 2     Epoxide Hydratase2
CEH2     Epoxide Hydrolase 2, Cytosolic2
SEH2     Epoxide Hydrolase, Soluble2
Bifunctional Epoxide Hydrolase 22     

External Ids:    HGNC: 34021   Entrez Gene: 20532   Ensembl: ENSG000001209157   OMIM: 1328115   UniProtKB: P349133   

Export aliases for EPHX2 gene to outside databases

Previous GC identifers: GC08P027131 GC08P027853 GC08P027370 GC08P027404 GC08P025893


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EPHX2 Gene:
This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and
peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this
gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been
described. (provided by RefSeq, Feb 2012)

GeneCards Summary for EPHX2 Gene: 
EPHX2 (epoxide hydrolase 2, cytoplasmic) is a protein-coding gene. Diseases associated with EPHX2 include hypercholesterolemia, familial, due to ldlr defect, modifier of, and fetal hydantoin syndrome, and among its related super-pathways are Arachidonic acid metabolism and Metabolic pathways. GO annotations related to this gene include magnesium ion binding and protein homodimerization activity. An important paralog of this gene is EPHX4.

UniProtKB/Swiss-Prot: HYES_HUMAN, P34913
Function: Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene
oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic
epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid
phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid,
followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid,
12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate

Gene Wiki entry for EPHX2 (Epoxide hydrolase 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EPHX2 gene promoter:
         GR   PPAR-alpha   GR-beta   GR-alpha   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEPHX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for EPHX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPHX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21   Ensembl cytogenetic band:  8p21.2   HGNC cytogenetic band: 8p21

EPHX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHX2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P027348:  view genomic region     (about GC identifiers)

Start:
27,348,296 bp from pter      End:
27,403,081 bp from pter
Size:
54,786 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HYES_HUMAN, P34913 (See protein sequence)
Recommended Name: Bifunctional epoxide hydrolase 2  
Size: 555 amino acids; 62616 Da
Cofactor: Magnesium
Subunit: Homodimer
Subcellular location: Cytoplasm. Peroxisome
6/16 PDB 3D structures from and Proteopedia for EPHX2 (see all 16):
1S8O (3D)        1VJ5 (3D)        1ZD2 (3D)        1ZD3 (3D)        1ZD4 (3D)        1ZD5 (3D)    
Secondary accessions: B2Z3B1 B3KTU8 B3KUA0 G3V134 J3KPH7 Q16764 Q9HBJ1 Q9HBJ2
Alternative splicing: 3 isoforms:  P34913-1   P34913-2   P34913-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EPHX2: NX_P34913

Explore proteomics data for EPHX2 at MOPED 

Post-translational modifications:

  • UniProtKB: The N-terminus is blocked
  • UniProtKB: The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It
    may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation
    (Probable)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P34913

  • EPHX2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EPHX2 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001243411.1  NP_001243412.1  NP_001243413.1  NP_001970.2  

    ENSEMBL proteins: 
     ENSP00000430269   ENSP00000430779   ENSP00000428875   ENSP00000430302   ENSP00000369843  
     ENSP00000427956   ENSP00000428191  
    Reactome Protein details: P34913
    Human Recombinant Protein Products for EPHX2: 
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    Novus Biologicals EPHX2 Proteins
    Novus Biologicals EPHX2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EPHX2 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005777peroxisome IDA16314446
    GO:0005794Golgi apparatus IDA--
    GO:0005829cytosol TAS--

    EPHX2 for ontologies           About GeneDecksing



    EPHX2 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for EPHX2 

    Assay Products for EPHX2: 
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    Cloud-Clone Corp. ELISAs for EPHX2 
    Cloud-Clone Corp. CLIAs for EPHX2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR011945 HAD-SF_ppase_IA/epoxid_hydro_N
     IPR000073 AB_hydrolase_1
     IPR023214 HAD-like_dom
     IPR000639 Epox_hydrolase-like
     IPR006402 HAD-SF_hydro_IA_v3

    Graphical View of Domain Structure for InterPro Entry P34913

    ProtoNet protein and cluster: P34913

    4 Blocks protein domains:
    IPB000073 Alpha/beta hydrolase fold
    IPB000639 Epoxide hydrolase signature
    IPB003089 Alpha/beta hydrolase fold signature
    IPB005833 Haloacid dehalogenase/epoxide hydrolase family signature


    UniProtKB/Swiss-Prot: HYES_HUMAN, P34913
    Domain: The N-terminal domain has phosphatase activity. The C-terminal domain has epoxide hydrolase activity
    Similarity: Belongs to the AB hydrolase superfamily. Epoxide hydrolase family


    EPHX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HYES_HUMAN, P34913
    Function: Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene
    oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic
    epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid
    phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid,
    followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid,
    12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate
    Catalytic activity: An epoxide + H(2)O = a glycol
    Catalytic activity: (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H(2)O =
    (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate
    Biophysicochemical properties: Kinetic parameters: KM=21 uM for threo-9,10-phosphonooxy-hydroxy-octadecanoic acid;
    KM=1.1 mM for p-nitrophenyl phosphate; Vmax=338 nmol/min/mg enzyme with threo-9,10-phosphonooxy-
    hydroxy-octadecanoic acid; Vmax=5.8 nmol/min/mg enzyme with p-nitrophenyl phosphate;
    Induction: By compounds that cause peroxisome proliferation such as clofibrate, tiadenol and fenofibrate

         Genatlas biochemistry entry for EPHX2:
    epoxyde hydrolase,soluble

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA12574510
    GO:0003824catalytic activity ----
    GO:00038694-nitrophenylphosphatase activity IDA12574508
    GO:0004301epoxide hydrolase activity TAS--
    GO:0005102receptor binding IPI--
         
    EPHX2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for EPHX2:
     Increased G2M DNA content  Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ephx2):
     cardiovascular system  homeostasis/metabolism 

    EPHX2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ephx2tm1Gonz for EPHX2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for EPHX2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EPHX2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EPHX2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EPHX2 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate EPHX2:
    hsa-miR-4311
    SwitchGear 3'UTR luciferase reporter plasmidEPHX2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for EPHX2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EPHX2 (NM_001979)
    Sino Biological Human cDNA Clone for EPHX2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHX2
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHX2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EPHX2 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Arachidonic acid metabolism
    Arachidonic acid metabolism0.44
    HETE and HPETE biosynthesis and metabolism0.35
    Arachidonic acid metabolism0.44
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    3Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
    Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)0.55
    Arachidonate Epoxygenase / Epoxide Hydrolase0.36
    4Biological oxidations
    metapathway biotransformation0.41
    5Naphthalene metabolism
    Naphthalene metabolism0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for EPHX2
        Naphthalene metabolism
    HETE and HPETE biosynthesis and metabolism
    ATP/ITP metabolism


    3 GeneGo (Thomson Reuters) Pathways for EPHX2
        HETE and HPETE biosynthesis and metabolism
    Naphthalene metabolism
    ATP/ITP metabolism

    2 BioSystems Pathways for EPHX2
        Arachidonate Epoxygenase / Epoxide Hydrolase
    metapathway biotransformation


    4        Reactome Pathways for EPHX2
        Metabolism
    Arachidonic acid metabolism
    Metabolism of lipids and lipoproteins
    Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)


    3         Kegg Pathways  (Kegg details for EPHX2):
        Arachidonic acid metabolism
    Metabolic pathways
    Peroxisome


    EPHX2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EPHX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for EPHX2 (P349132, 3 ENSP000003698434) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NIPSNAP3AQ9UFN02, 3, ENSP000003638994MINT-63686 I2D: score=4 STRING: ENSP00000363899
    CYP2B6ENSP000003246484STRING: ENSP00000324648
    CYP2C18ENSP000002859794STRING: ENSP00000285979
    CYP2C19ENSP000003603724STRING: ENSP00000360372
    CYP2C8ENSP000003603174STRING: ENSP00000360317
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process NAS10862610
    GO:0006874cellular calcium ion homeostasis NAS10862610
    GO:0006954inflammatory response NAS10862610
    GO:0008217regulation of blood pressure NAS10862610
    GO:0009636response to toxic substance NAS10862610

    EPHX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EPHX2 for compounds           About GeneDecksing

    EMD Millipore small molecules for EPHX2:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for EPHX2

    Browse Tocris compounds for EPHX2 (HYES)

    10/12 HMDB Compounds for EPHX2 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    11,12-DiHETrE11,12-Dihydroxyeicosatrienoic acid (see all 13)192461-95-3--
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    14,15-DiHETrE14,15-dihydroxy-5Z,8Z,11Z-eicosatrienoic acid (see all 10)77667-09-5--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
    15-Epi-lipoxin A415-epi-LXA(,4) (see all 7)----
    15-Epi-lipoxin B55(S),14(R),15(S)-trihydroxy-6E,8Z,10E,12E,17Z-eicosapentaenoic acid anion (see all 3)----
    5,6-DHET5,6-DiHETrE (see all 9)213382-49-1--
    5,6-Epoxy-8,11,14-eicosatrienoic acid5,6-epoxy-8Z,11Z,14Z-eicosatrienoic acid (see all 9)81246-84-6--
    8,9-DiHETrE(5Z,11Z,14Z)-8,9-Dihydroxyicosa-5,11,14-trienoic acid (see all 10)192461-96-4--
    8,9-Epoxyeicosatrienoic acid8,9-epoxy-5Z,11Z,14Z-eicosatrienoic acid (see all 10)81246-85-7--

    7 DrugBank Compounds for EPHX2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-Cyclohexyl-N'-(4-Iodophenyl)Urea-- --target--17139284 17016423 10592235
    4-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}BUTANOIC ACID-- --target--10592235
    6-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEXANOIC ACID-- --target--10592235
    7-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEPTANOIC ACID-- --target--10592235
    N-Cyclohexyl-N'-(Propyl)Phenyl Urea-- --target--10592235
    N-Cyclohexyl-N'-Decylurea-- --target--10592235
    N-[(CYCLOHEXYLAMINO)CARBONYL]GLYCINE-- --target--10592235

    10/82 Novoseek inferred chemical compound relationships for EPHX2 gene (see all 82)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    epoxide 98.7 1098 14665429 (9), 9635886 (8), 1958232 (7), 19671760 (7) (see all 99)
    cis-stilbene oxide 85 2 2272333 (1), 1936901 (1)
    tcpo 80.9 8 8240407 (1), 8961944 (1), 10426800 (1), 11397396 (1) (see all 6)
    3-butene-1,2-diol 80.8 1 9280411 (1)
    styrene oxide 80.1 19 8452475 (2), 7818768 (2), 8314768 (1), 7694107 (1) (see all 12)
    benzo(a)pyrene 4,5-oxide 79.6 1 8314768 (1)
    butadiene monoxide 78 16 9280411 (3), 1638680 (2), 9016811 (1), 8070886 (1) (see all 8)
    (2,3-epoxypropyl)benzene 77.2 1 8886614 (1)
    benzeneoxide 73.8 1 8723729 (1)
    valpromide 73.5 4 8877250 (1), 1352988 (1), 8156045 (1), 8453849 (1)

    Search CenterWatch for drugs/clinical trials and news about EPHX2 / HYES

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EPHX2 gene (4 alternative transcripts): 
    NM_001256482.1  NM_001256483.1  NM_001256484.1  NM_001979.5  

    Unigene Cluster for EPHX2:

    Epoxide hydrolase 2, cytoplasmic
    Hs.212088  [show with all ESTs]
    Unigene Representative Sequence: NM_001979
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521400(uc003xfu.3 uc010luv.3 uc003xfv.3 uc010luw.3)
    ENST00000518328 ENST00000520623(uc011lam.1 uc010lut.1) ENST00000517536
    ENST00000521780 ENST00000380476 ENST00000518379 ENST00000520666 ENST00000521684
    ENST00000523827 ENST00000521924 ENST00000523326
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    GenScript: all cDNA clones in your preferred vector: EPHX2 (NM_001979)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHX2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPHX2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPHX2

    Additional mRNA sequence: 

    AF233334.1 AF233335.1 AF233336.1 AK096089.1 AK096770.1 AK294065.1 AK303904.1 AK308041.1 
    AK310507.1 BC007708.2 BC011628.2 BC013874.2 BT006885.1 L05779.1 

    17 DOTS entries:

    DT.75103390  DT.100809993  DT.315914  DT.100806588  DT.100809998  DT.100809988  DT.101978938  DT.100809987 
    DT.315917  DT.120636852  DT.91744851  DT.100765345  DT.100809991  DT.120636795  DT.120636851  DT.91744853 
    DT.75132055 

    24/279 AceView cDNA sequences (see all 279):

    AI245624 R01942 BX334055 AU122049 BT006885 AI399683 BP343698 BF330315 
    AF233334 CB121777 NM_001979 N26807 BX379396 BX642653 AA300747 CR590101 
    BC011628 BI771523 BC007708 BU729448 AU104142 R29243 CB137687 BC013874 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for EPHX2 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
    SP1:                                -                                   -                             -                                                         
    SP2:                                -     -     -                       -                             -                                                         
    SP3:                                -     -                             -                             -                                                         
    SP4:                                -                                   -                             -     -                                                   
    SP5:        -     -                 -                                                                                                                           

    ExUns: 18 ^ 19 ^ 20 ^ 21
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for EPHX2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EPHX2 expression in normal human tissues (normalized intensities)      EPHX2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGCATCGT
    EPHX2 Expression
    About this image


    EPHX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/atrium   
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Lower Urinary Tract (Urinary System)
             visceral organ   
     
     Neural Tube (Nervous System)
             Rhombencephalon
     
     Breast (Uncategorized)
             MAMMARY GLAND   

    See EPHX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EPHX2

    SOURCE GeneReport for Unigene cluster: Hs.212088
        SABiosciences Expression via Pathway-Focused PCR Arrays including EPHX2 (see all 6): 
              Hypertension in human mouse rat
              Oxidative Stress in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for EPHX2 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ephx21 , 5 epoxide hydrolase 2, cytoplasmic1, 5 79.08(n)1
    73.42(a)1
      14 (34.36 cM)5
    138501  NM_007940.31  NP_031966.21 
     660843775 
    chicken
    (Gallus gallus)
    Aves EPHX21 epoxide hydrolase 2, cytoplasmic 63.04(n)
    57.46(a)
      421999  NM_001033645.1  NP_001028817.1 
    lizard
    (Anolis carolinensis)
    Reptilia EPHX26
    Uncharacterized protein
    48(a)
    1 ↔ 1
    GL343696.1(30401-115717)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.180492 Xenopus laevis transcribed sequence with weak similarity more 74.27(n)    BG884818.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ephx21 epoxide hydrolase 2, cytoplasmic 56.22(n)
    50.75(a)
      494099  NM_001008642.1  NP_001008642.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ceeh-16
    ceeh-26
    Protein CEEH-2, isoform a
    22(a)
    21(a)
    many ↔ many
    many ↔ many
    III(828590-832277)
    V(10356282-10357903)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G510001 putative epoxide hydrolase 46.86(n)
    37.01(a)
      824264  NM_114960.3  NP_190669.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g06364001 hypothetical protein 46.94(n)
    35.64(a)
      4352891  NM_001073896.1  NP_001067364.1 


    ENSEMBL Gene Tree for EPHX2 (if available)
    TreeFam Gene Tree for EPHX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EPHX2 gene
    EPHX42  EPHX32  
    2 SIMAP similar genes for EPHX2 using alignment to 5 protein entries:     HYES_HUMAN (see all proteins):
    ACAD10    EPHX4

    EPHX2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1511 SNPs in EPHX2 are shown (see all 1511)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs7511411,2,4
    C,F,O,A,Hpathogenic127611511(-) GGACCC/TGGTAA 8 Q R mis1 ese357Minor allele frequency- T:0.12MN NS EA NA WA CSA EU 12359
    VAR_0553924
    ----see VAR_0553922 G A mis40--------
    VAR_0553954
    ----see VAR_0553952 P L mis40--------
    rs712205971,2
    C--27348256(+) ACACA-/CAC   
       ACACA
    CACAC
    4 -- us2k11Minor allele frequency- CACACACA:0.00NA 2
    rs101126391,2
    C,F,H--27350564(+) tcctcG/Agtaga 4 -- int18Minor allele frequency- A:0.08EA NS NA CSA WA 530
    rs344768811,2
    C,F--27350981(+) TTTATT/CTATTG 4 -- int14Minor allele frequency- C:0.08NA 126
    rs625042691,2
    C,F--27351165(+) TTCCTG/CTGGCA 4 -- int13Minor allele frequency- C:0.15WA NA 240
    rs591628741,2
    C--27351219(+) GTGGG-/GAGGCA 4 -- int10--------
    rs732273151,2
    C--27351674(+) TTACTA/GTGATC 4 -- int10--------
    rs101104051,2
    C,F--27352150(+) tttgtT/Cccccc 4 -- int11Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for EPHX2 (27348296 - 27403081 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for EPHX2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv437612CNV Loss16327808
    esv28788CNV Loss19812545
    nsv890697CNV Loss21882294
    nsv831275CNV Loss17160897
    nsv890696CNV Gain21882294


    Human Gene Mutation Database (HGMD): EPHX2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 132811   
    OMIM disorders: 143890  
    20/42 diseases for EPHX2 (see all 42):    About MalaCards
    hypercholesterolemia, familial, due to ldlr defect, modifier of    fetal hydantoin syndrome    familial hypercholesterolemia    staphyloenterotoxemia
    hypercholesterolemia    hellp syndrome    toxic shock syndrome    mastitis
    pre-eclampsia    ichthyosis    eclampsia    albinism
    cytochrome p450    atherosclerosis    choroiditis    colon adenocarcinoma
    coronary heart disease    hepatocellular carcinoma    non-hodgkin lymphoma    hodgkin's lymphoma

    1 disease from the University of Copenhagen DISEASES database for EPHX2:
    Hypertension

    EPHX2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/27 Novoseek inferred disease relationships for EPHX2 gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fetal hydantoin syndrome 71.5 1 8711731 (1)
    inflammation 32.8 34 19519461 (2), 16962614 (2), 15196990 (1), 15963942 (1) (see all 21)
    nasal epithelium 21.9 1 11551533 (1)
    hellp syndrome 13.3 1 11283205 (1)
    cancer lung 12.2 4 1538419 (1), 19721221 (1), 12935919 (1), 7728947 (1)
    hepatocellular carcinoma 12 6 8380119 (3), 7892276 (1), 8851825 (1), 1339049 (1)
    acute respiratory distress 11.4 1 17435320 (1)
    cardiovascular diseases 10.2 12 16961727 (2), 18537101 (2), 16729954 (1), 20425256 (1) (see all 8)
    lymphoma 4.91 2 11406608 (1), 12397416 (1)
    respiratory distress syndrome 3.46 1 17435320 (1)

    Genetic Association Database (GAD): EPHX2
    Human Genome Epidemiology (HuGE) Navigator: EPHX2 (39 documents)

    Export disorders for EPHX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EPHX2 gene, integrated from 9 sources (see all 417):
    (articles sorted by number of sources associating them with EPHX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study. (PubMed id 16595607)1, 4, 9 Lee C.R....Zeldin D.C. (2006)
    2. Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study. (PubMed id 18537101)1, 4, 9 Burdon K.P....Bowden D.W. (2008)
    3. Genetic variation in soluble epoxide hydrolase (EPHX2) is associated with an increased risk of ischemic stroke in white Europeans. (PubMed id 18323494)1, 4, 9 Gschwendtner A....Dichgans M. (2008)
    4. Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis. (PubMed id 15096040)1, 2, 9 Gomez G.A.... Christianson D.W. (2004)
    5. Genetic polymorphisms of microsomal and soluble epoxide hydrolase and the risk of Parkinson's disease. (PubMed id 11692079)1, 4, 9 Farin F.M....Checkoway H. (2001)
    6. Identification and functional characterization of human soluble epoxide hydrolase genetic polymorphisms. (PubMed id 10862610)1, 2, 9 Sandberg M.... Omiecinski C.J. (2000)
    7. Genetic variations in soluble epoxide hydrolase and graft function in kidney transplantation. (PubMed id 18589104)1, 4, 9 Lee S.H....Kim Y.S. (2008)
    8. Association of soluble epoxide hydrolase gene polymorphism with insulin resistance in type 2 diabetic patients. (PubMed id 15845398)1, 4, 9 Ohtoshi K....Yamasaki Y. (2005)
    9. Polymorphism of the soluble epoxide hydrolase is associated with coronary artery calcification in African-American subjects: The Coronary Artery Risk Development in Young Adults (CARDIA) study. (PubMed id 14732757)1, 4, 9 Fornage M....Wong N.D. (2004)
    10. Structural characterization of the human soluble epoxide hydrolase gene (EPHX2). (PubMed id 8619856)1, 2, 9 Sandberg M. and Meijer J. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2053 HGNC: 3402 AceView: EPHX2 Ensembl:ENSG00000120915 euGenes: HUgn2053
    ECgene: EPHX2 Kegg: 2053 H-InvDB: EPHX2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EPHX2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EPHX2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ephx2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EPHX2 gene:
    Search GeneIP for patents involving EPHX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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