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EPHB6 Gene

protein-coding   GIFtS: 69
GCID: GC07P142552

EPH Receptor B6

(Previous name: EphB6)
  See EPHB6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
EPH Receptor B61 2     Ephrin Type-B Receptor 62
HEP2 3 5     Human Kinase-Defective Eph-Family Receptor Protein2
Tyrosine-Protein Kinase-Defective Receptor EPH-62 3     EC 2.7.10.18
EphB61     

External Ids:    HGNC: 33961   Entrez Gene: 20512   Ensembl: ENSG000001061237   OMIM: 6027575   UniProtKB: O151973   

Export aliases for EPHB6 gene to outside databases

Previous GC identifers: GC07P140878 GC07P141946 GC07P142023 GC07P142069 GC07P142262 GC07P136891


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EPHB6 Gene:
This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family
proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain.
Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated
during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for EPHB6 Gene:
EPHB6 (EPH receptor B6) is a protein-coding gene. Diseases associated with EPHB6 include familial colorectal cancer, and gliosarcoma. GO annotations related to this gene include ephrin receptor activity and receptor activity. An important paralog of this gene is EPHB1.

UniProtKB/Swiss-Prot: EPHB6_HUMAN, O15197
Function: Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2.
Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with
ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation
with ephrin-B2

Gene Wiki entry for EPHB6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  NT_187562.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the EPHB6 gene promoter:
         CREB   NF-1/L   NF-1   deltaCREB   HNF-4alpha2   Gfi-1   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): EPHB6 promoter sequence
   Search Chromatin IP Primers for EPHB6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EPHB6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q33-q35   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q33-q35

EPHB6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHB6 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P142552:  view genomic region     (about GC identifiers)

Start:
142,552,792 bp from pter      End:
142,568,847 bp from pter
Size:
16,056 bases      Orientation:
plus strand

2 alternative locations:
Chr7+,CRA_TCAG 141,954,656-141,970,711      Chr7+,NW_003571040 1,058,157-1,074,207     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EPHB6_HUMAN, O15197 (See protein sequence)
Recommended Name: Ephrin type-B receptor 6 precursor  
Size: 1021 amino acids; 110700 Da
Subunit: Interacts with CBL and EPHB1. Interacts with FYN; this interaction takes place in a ligand-independent
manner
Sequence caution: Sequence=AAD03058.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI10608.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAP20939.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA21560.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=EAL23775.1; Type=Erroneous gene model prediction;
Sequence=EAW51902.1; Type=Erroneous gene model prediction;
Secondary accessions: A4D2I7 A8CDT5 D3DXD3 Q2TB23 Q2TB24
Alternative splicing: 3 isoforms:  O15197-1   O15197-2   O15197-3   

Explore the universe of human proteins at neXtProt for EPHB6: NX_O15197

Explore proteomics data for EPHB6 at MOPED

Post-translational modifications: 

  • Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by
    transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation
    of the receptor may act as a switch on the functional transition from cell adhesion/attraction to
    de-adhesion/repulsion1
  • Glycosylation2 at Asn480
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for EPHB6 (O15197) (see all 6)
     DTIAADE  LDSFLRQ  GERPYWD  LEGVVTKS 


    See EPHB6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001267723.1  NP_001267724.1  NP_004436.3  

    ENSEMBL proteins: 
     ENSP00000410789   ENSP00000411175   ENSP00000404786   ENSP00000376684   ENSP00000409061  

    EPHB6 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    EPH: EPH receptors
    SAMD: Sterile alpha motif (SAM) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: EPH receptor B6
    Ephrin receptor family
    Ephrin receptor family

    Selected InterPro protein domains (see all 15):
     IPR003961 Fibronectin_type3
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold
     IPR000719 Prot_kinase_dom
     IPR016257 Tyr_kinase_ephrin_rcpt

    Graphical View of Domain Structure for InterPro Entry O15197

    ProtoNet protein and cluster: O15197

    5 Blocks protein domains:
    IPB001090 Ephrin receptor
    IPB001426 Receptor tyrosine kinase
    IPB001660 Sterile alpha motif SAM
    IPB003962 Fibronectin type III repeat signature
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: EPHB6_HUMAN, O15197
    Domain: The protein kinase domain is predicted to be catalytically inactive. Its extracellular domain is capable
    of promoting cell adhesion and migration in response to low concentrations of ephrin-B2, but its cytoplasmic
    domain is essential for cell repulsion and inhibition of migration induced by high concentrations of ephrin-B2
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Find genes that share domains with EPHB6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EPHB6_HUMAN, O15197
    Function: Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2.
    Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with
    ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation
    with ephrin-B2

         Genatlas biochemistry entry for EPHB6:
    EPH-related tyrosine kinase receptor,135kDa,binding ephrin B6,expressed in projecting neurons and their target
    fields,involved in short-range contact-mediated axonal guidance

         Enzyme Number (IUBMB): EC 2.7.10.12

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004872receptor activity TAS9207182
    GO:0005003ephrin receptor activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with EPHB6           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for EPHB6:
     Decreased focal adhesion (FA)   Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  High actin ratio cells 

         14 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Ephb6):
     behavior/neurological  digestive/alimentary  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  no phenotypic analysis  normal 
     renal/urinary system  reproductive system  skeleton  tumorigenesis 

    Find genes that share phenotypes with EPHB6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for EPHB6: Ephb6/Trpv6Ephb6/tm1.2Mfre Ephb6tm1Tom Ephb6/Trpv6Ephb6/tm1Mhed Ephb6tm2Tom Ephb6/Trpv6Ephb6/tm2.1Mfre

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    hsa-miR-623 hsa-miR-204 hsa-miR-1248 hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidEPHB6 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for EPHB6 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EPHB6_HUMAN, O15197: Membrane; Single-pass type I membrane protein
    EPHB6_HUMAN, O15197: Isoform 3: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    plasma membrane3
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005887integral component of plasma membrane IEA--
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with EPHB6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EPHB6 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    Ephrin-Eph Signaling0.58
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.41
    Actin Nucleation by ARP-WASP Complex0.66


    Find genes that share SuperPaths with EPHB6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EPHB6 (see all 30)
        MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Ephrin-Eph Signaling

    1 Cell Signaling Technology (CST) Pathway for EPHB6
        Tyrosine Kinases / Adaptors

    2 GeneGo (Thomson Reuters) Pathways for EPHB6
        Cytoskeleton remodeling Reverse signaling by ephrin B
    Cell adhesion Ephrins signaling



    1 Kegg Pathway  (Kegg details for EPHB6):
        Axon guidance

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EPHB6
    Interactions:

        GeneGlobe Interaction Network for EPHB6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for EPHB6 (O151972, 3 ENSP000003766844) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SAT1P216732, 3MINT-63555 I2D: score=5 
    MLLT4P551962, 3, ENSP000003836234MINT-58217 I2D: score=4 STRING: ENSP00000383623
    CRKP461083, ENSP000003005744I2D: score=2 STRING: ENSP00000300574
    CRKLP461093, ENSP000003463004I2D: score=2 STRING: ENSP00000346300
    EFNB2P527993, ENSP000002453234I2D: score=1 STRING: ENSP00000245323
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway ----
    GO:0035898parathyroid hormone secretion IEA--
    GO:0048013ephrin receptor signaling pathway ----
    GO:0055074calcium ion homeostasis IEA--

    Find genes that share ontologies with EPHB6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EPHB6

    2 HMDB Compounds for EPHB6    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 Novoseek inferred chemical compound relationship for EPHB6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 44 6 15955811 (3), 11466354 (2), 19513565 (1)



    Find genes that share compounds with EPHB6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EPHB6 gene (3 alternative transcripts): 
    NM_001280794.1  NM_001280795.1  NM_004445.4  

    Unigene Cluster for EPHB6:

    EPH receptor B6
    Hs.380089  [show with all ESTs]
    Unigene Representative Sequence: BC051028
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000442129(uc003wbu.3) ENST00000497095 ENST00000466783 ENST00000425995
    ENST00000422643 ENST00000486511(uc003wbv.3) ENST00000471581 ENST00000476059
    ENST00000392957(uc010lot.1 uc011kst.2 uc011ksu.2 uc003wbs.3 uc003wbt.3)
    ENST00000411471
    miRNA
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    Additional mRNA sequence: 

    BC015495.1 BC047892.1 BC051028.1 BC056159.1 BC110606.1 BC110607.1 D83492.1 EU054308.1 

    12 DOTS entries:

    DT.313090  DT.91679781  DT.75106766  DT.99959485  DT.100678843  DT.95108033  DT.100019851  DT.102821285 
    DT.121076990  DT.100022150  DT.100816445  DT.121076810 

    7 AceView cDNA sequences:

    AL832533 BC056159 BC051028 BC015495 D83492 NM_004445 BC047892 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EPHB6 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19
    SP1:                                                                                                                                                
    SP2:                                                                                                                                                
    SP3:                                                                    -                                                                           
    SP4:                                                                    -                                                                           
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for EPHB6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EPHB6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGACGTGA
    EPHB6 Expression
    About this image


    EPHB6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
    EPHB6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EPHB6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.380089

    UniProtKB/Swiss-Prot: EPHB6_HUMAN, O15197
    Tissue specificity: Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level).
    Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung,
    liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform
    3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3
    is not detected in normal tissues

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for EPHB6 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ephb61 , 5 Eph receptor B61, 5 86.74(n)1
    92.6(a)1
      6 (19.77 cM)5
    138481  NM_001146351.11  NP_001139823.11 
     416054825 
    chicken
    (Gallus gallus)
    Aves EPHB66
    ephrin type-B receptor 5 precursor
    58(a)
    1 ↔ 1
    1(77460198-77533109)
    lizard
    (Anolis carolinensis)
    Reptilia EPHB66
    EPH receptor B6
    60(a)
    1 ↔ 1
    GL343499.1(174954-367930)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-26c10.61 si:dkey-26c10.6 55.76(n)
    51.06(a)
      572411  XM_005173518.1  XP_005173575.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Eph6
    Eph receptor tyrosine kinase
    31(a)
    1 → many
    4(631310-643096)


    ENSEMBL Gene Tree for EPHB6 (if available)
    TreeFam Gene Tree for EPHB6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EPHB6 gene
    EPHB12  EPHA22  EPHB32  EPHA42  EPHA52  EPHA62  EPHA12  EPHB22  
    EPHA82  EPHA32  EPHA72  EPHA102  EPHB42  
    Selected SIMAP similar genes for EPHB6 using alignment to 4 protein entries:     EPHB6_HUMAN (see all proteins) (see all similar genes):
    EPHB2 variant protein    EPHA6    EPHB3    EPHB2    EPHA4    EPHB1
    EPHA7    EPHA3    EPHA2    FGR    EPHB4    EPHA8
    TXK    EPHA5    FES    tec    EPHA10    BTK kinase deficient isoform 2

    Find genes that share paralogs with EPHB6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EPHB6 (see all 570)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360924
    A colorectal cancer sample4--see VAR_0360922 A P mis40--------
    VAR_0360944
    A colorectal cancer sample4--see VAR_0360942 D G mis40--------
    VAR_0421984
    A glioblastoma multiforme sample4--see VAR_0421982 E K mis40--------
    VAR_0421964
    An ovarian mucinous carcinoma sample4--see VAR_0421962 P S mis40--------
    VAR_0360934
    A colorectal cancer sample4--see VAR_0360932 R Q mis40--------
    VAR_0360914
    A colorectal cancer sample4--see VAR_0360912 D N mis40--------
    rs1914315401,2
    --142550888(+) AATTAA/GGATGC 1 -- us2k10--------
    rs81770901,2
    C,F,H--142551004(+) TTACAC/TAAGCC 1 -- us2k118Minor allele frequency- T:0.07NS EA NA WA 1828
    rs81771671,2
    C--142551031(+) TCATTT/ACATAT 1 -- us2k13Minor allele frequency- A:0.01NS NA 94
    rs1870323681,2
    --142551080(+) AGAAGA/GCAGAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for EPHB6 (142552792 - 142568847 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for EPHB6:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv7504n71CNV Loss21882294
    nsv428187CNV Loss18775914
    nsv520735CNV Loss19592680
    nsv889274CNV Loss21882294
    nsv526015CNV Gain19592680
    nsv831168CNV Gain17160897
    dgv2145e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): EPHB6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EPHB6
    DNA2.0 Custom Variant and Variant Library Synthesis for EPHB6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602757    OMIM disorders: --

    3 diseases for EPHB6:    
    About MalaCards
    familial colorectal cancer    gliosarcoma    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for EPHB6:
    Neuroblastoma

    Find genes that share disorders with EPHB6           About GenesLikeMe

    4 Novoseek inferred disease relationships for EPHB6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 29.2 10 14612926 (5), 20181626 (1), 15147954 (1)
    metastasis 27.2 6 14612926 (4), 19513565 (1)
    cancer 11.4 4 20181626 (1), 14612926 (1), 15147954 (1)
    tumors 10.6 4 10984508 (1), 20181626 (1), 14612926 (1)

    Human Genome Epidemiology (HuGE) Navigator: EPHB6 (2 documents)

    Export disorders for EPHB6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EPHB6 gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with EPHB6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Biphasic functions of the kinase-defective Ephb6 receptor in cell adhesion and migration. (PubMed id 15955811)1, 2, 9 Matsuoka H.... Nakamoto M. (J. Biol. Chem. 2005)
    2. Expression of a kinase-defective Eph-like receptor in the normal human brain. (PubMed id 9207182)1, 2, 9 Matsuoka H.... Matsui T. (Biochem. Biophys. Res. Commun. 1997)
    3. EphB6 receptor significantly alters invasiveness and other phenotypic characteristics of human breast carcinoma cells. (PubMed id 19234485)1, 2 Fox B.P. and Kandpal R.P. (Oncogene 2009)
    4. Erythropoietin-producing hepatocyte B6 variant-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in human leukocyte antigen-A2+ glioma patients. (PubMed id 18754880)1, 2 Jin M....Yamada A. (Cancer Sci. 2008)
    5. Identification of EphB6 variant-derived epitope peptides recognized by cytotoxic T-lymphocytes from HLA-A24+ malignant glioma patients. (PubMed id 18425388)1, 2 Jin M.... Yamada A. (Oncol. Rep. 2008)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    7. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    8. The EphB6 receptor inhibits JNK activation in T lymphocytes and modulates T cell receptor-mediated responses. (PubMed id 12517763)1, 2 Freywald A.... Roifman C.M. (J. Biol. Chem. 2003)
    9. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    10. The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1. (PubMed id 11713248)1, 2 Freywald A.... Roifman C.M. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2051 HGNC: 3396 AceView: EPHB6 Ensembl:ENSG00000106123 euGenes: HUgn2051
    ECgene: EPHB6 Kegg: 2051 H-InvDB: EPHB6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EPHB6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EPHB6 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/ephb6/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EPHB6 gene:
    Search GeneIP for patents involving EPHB6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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