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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

EPHB6 Gene

protein-coding GIFtS: 68
GCID: GC07P142552

EPH receptor B6

(Previous name: EphB6 )

Explore 22 diseases affiliated with
EPHB6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
EPH Receptor B6¹ ²
HEP¹ ² ³ ⁵
Tyrosine-Protein Kinase-Defective Receptor EPH-6² ³
EphB6¹
Ephrin Type-B Receptor 6²
EC 2.7.10.1⁸

External Ids:	HGNC: 3396¹	Entrez Gene: 2051²	Ensembl: ENSG00000106123⁷	OMIM: 602757⁵	UniProtKB: O15197³

ORGUL members:	fRNAdb¹⁰:FR333079
	H-InvDB:HIT000088716
	NCBI:BC015495
	NONCODE:n341347 n333433
	RNAdb:HIV2429

Export aliases for EPHB6 gene to outside databases

Previous GC identifers: GC07P140878 GC07P141946 GC07P142023 GC07P142069 GC07P142262 GC07P136891

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EPHB6:

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous

system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class,

which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are

transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their

extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make

up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks

the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: EPHB6_HUMAN, O15197

Function: Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates

cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits

JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2

Gene Wiki entry for EPHB6

fRNAdb sequence ontology for EPHB6:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for EPHB6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the EPHB6 gene promoter:
CREB NF-1/L NF-1 deltaCREB HNF-4alpha2 Gfi-1 HNF-4alpha1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): EPHB6 promoter sequence

Search SABiosciences Chromatin IP Primers for EPHB6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPHB6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q33-q35 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q33-q35

EPHB6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHB6 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P142552: view genomic region (about GC identifiers)

Start:	142,552,792 bp from pter	End:	142,568,847 bp from pter
Size:	16,056 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 141,954,656-141,970,711

ORGUL member locations:
Legend (see complete legend)

n341347
FR0333079
n333433

lncRNA
Full Legend

142552822 142560835 142568847 chr7

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: EPHB6_HUMAN, O15197 (See protein sequence)

Recommended Name: Ephrin type-B receptor 6 precursor

Size: 1021 amino acids; 110700 Da

Subunit: Interacts with CBL and EPHB1. Interacts with FYN; this interaction takes place in a ligand-independent manner

Subcellular location: Membrane; Single-pass type I membrane protein

Subcellular location: Isoform 3: Secreted (Probable)

Sequence caution: Sequence=AAD03058.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=AAI10608.2; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAP20939.1;

Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA21560.1; Type=Erroneous initiation;

Note=Translation N-terminally extended; Sequence=EAL23775.1; Type=Erroneous gene model prediction;

Sequence=EAW51902.1; Type=Erroneous gene model prediction;

Secondary accessions: A4D2I7 A8CDT5 D3DXD3 Q2TB23 Q2TB24

Alternative splicing: 3 isoforms: O15197-1 O15197-2 O15197-3

Explore the universe of human proteins at neXtProt for EPHB6: NX_O15197

Post-translational modifications:

Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by

transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the

receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O15197

4/6 DME Specific Peptides for EPHB6 (O15197) (see all 6)

DTIAADE

LDSFLRQ

GERPYWD

LEGVVTKS

EPHB6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004436.2

ENSEMBL proteins:

ENSP00000410789 ENSP00000411175 ENSP00000404786 ENSP00000376684 ENSP00000409061

Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for EPHB6

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005887	integral to plasma membrane	IEA	--

EPHB6 for ontologies About GeneDecksing

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Assay Products for EPHB6:

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	Uscn ELISAs and CLIAs for EPHB6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

EPHB6 for domains About GeneDecksing

5/13 InterPro domains/families (see all 13):

IPR003961 Fibronectin_type3

IPR011009 Kinase-like_dom

IPR013783 Ig-like_fold

IPR000719 Prot_kinase_cat_dom

IPR016257 Tyr_kinase_ephrin_rcpt

Graphical View of Domain Structure for InterPro Entry O15197

ProtoNet protein and cluster: O15197

5 Blocks protein families:

IPB001090 Ephrin receptor

IPB001426 Receptor tyrosine kinase

IPB001660 Sterile alpha motif SAM

IPB003962 Fibronectin type III repeat signature

IPB011510 Sterile alpha motif homology 2

UniProtKB/Swiss-Prot: EPHB6_HUMAN, O15197

Domain: The protein kinase domain is predicted to be catalytically inactive. Its extracellular domain is capable of

promoting cell adhesion and migration in response to low concentrations of ephrin-B2, but its cytoplasmic domain is

essential for cell repulsion and inhibition of migration induced by high concentrations of ephrin-B2

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily

Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain

Similarity: Contains 2 fibronectin type-III domains

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 SAM (sterile alpha motif) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: EPHB6_HUMAN, O15197

Function: Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates

cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits

JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2

Genatlas biochemistry entry for EPHB6:

EPH-related tyrosine kinase receptor,135kDa,binding ephrin B6,expressed in projecting neurons and their target

fields,involved in short-range contact-mediated axonal guidance

Enzyme Number (IUBMB): EC 2.7.10.1²

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		hsa-miR-623 hsa-miR-204 hsa-miR-1248 hsa-miR-211
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHB6

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	TAS	9207182
GO:0005003	ephrin receptor activity	IEA	--
GO:0005524	ATP binding	IEA	--

EPHB6 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for EPHB6:

Decreased focal adhesion (FA)

Decreased influenza A H1N1 (A/

Decreased influenza A/WSN/33 r

High actin ratio cells

Animal Models:
Mouse knock-outs for EPHB6: Ephb6/Trpv6^{Ephb6/tm1.2Mfre} Ephb6^tm1Tom Ephb6/Trpv6^{Ephb6/tm1Mhed} Ephb6^tm2Tom Ephb6/Trpv6^{Ephb6/tm2.1Mfre}
14 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Ephb6):

behavior/neurological	cellular	digestive/alimentary	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	immune system	integument	normal
renal/urinary system	reproductive system	skeleton	tumorigenesis

EPHB6 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58	P2Y Receptor Signaling	0.38

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Nanog in Mammalian ESC Pluripotency

	Nanog in Mammalian ESC Pluripotency	1.00			14-3-3 Induced Intracellular Signaling	0.59
	GSK3 Signaling	0.61			eNOS Signaling	0.48

Actin Nucleation by ARP-WASP Complex

	Actin Nucleation by ARP-WASP Complex	1.00			CDC42 Pathway	0.34
	Actin Nucleation and Branching	0.66

Cytoskeleton remodeling_Reverse signaling by ephrin B

Cytoskeleton remodeling_Reverse signaling by ephrin B

1.00

Cytoskeleton remodeling Reverse signaling by ephrin B

0.94

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for EPHB6

	Cytoskeleton remodeling Reverse signaling by ephrin B
	Cell adhesion Ephrins signaling

5/30 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EPHB6 (see all 30)

	MAPK Signaling
	Paxillin Interactions
	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Ephrin-Eph Signaling

2 GeneGo (Thomson Reuters) Pathways for EPHB6

	Cytoskeleton remodeling Reverse signaling by ephrin B
	Cell adhesion Ephrins signaling

1 Kegg Pathway (Kegg details for EPHB6):

Axon guidance

EPHB6 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for EPHB6

STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

5/25 Interacting proteins for EPHB6 (O15197^{2, 3} ENSP00000376684⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 25)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SAT1	P21673²^,³	MINT-63555 I2D: score=5
MLLT4	P55196²^,³, ENSP00000383623⁴	MINT-58217 I2D: score=4 STRING: ENSP00000383623
CRK	P46108³, ENSP00000300574⁴	I2D: score=2 STRING: ENSP00000300574
CRKL	P46109³, ENSP00000346300⁴	I2D: score=2 STRING: ENSP00000346300
EFNB2	P52799³, ENSP00000245323⁴	I2D: score=1 STRING: ENSP00000245323

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0035898	parathyroid hormone secretion	IEA	--
GO:0048013	ephrin receptor signaling pathway	--	--
GO:0055074	calcium ion homeostasis	IEA	--

EPHB6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EPHB6 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for EPHB6

2 HMDB Compounds for EPHB6 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--

1 Novoseek chemical compound relationship for EPHB6 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	44	6	15955811 (3), 11466354 (2), 19513565 (1)

Search CenterWatch for drugs/clinical trials and news about EPHB6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

1 fRNAdb Secondary structure:

REFSEQ mRNAs for EPHB6 gene:

NM_004445.3

Unigene Cluster for EPHB6:

EPH receptor B6

Hs.380089 [show with all ESTs]

Unigene Representative Sequence: BC051028

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000442129(uc003wbu.3) ENST00000497095 ENST00000466783 ENST00000425995

ENST00000422643 ENST00000486511(uc003wbv.3) ENST00000471581 ENST00000476059

ENST00000392957(uc010lot.1 uc011kst.2 uc011ksu.2 uc003wbs.3 uc003wbt.3)

ENST00000411471

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Additional cDNA sequence:

BC015495.1 BC047892.1 BC051028.1 BC056159.1 BC110606.1 BC110607.1 D83492.1 EU054308.1

12 DOTS entries:

DT.313090 DT.91679781 DT.75106766 DT.99959485 DT.100678843 DT.95108033 DT.100019851 DT.102821285

DT.121076990 DT.100022150 DT.100816445 DT.121076810

7 AceView cDNA sequences:

AL832533 BC051028 BC056159 BC047892 D83492 BC015495 NM_004445

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for EPHB6 (see all 7) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b	·	11c	^	12	^	13	^	14a	·	14b	^	15	^	16a	·	16b	^	17	^	18	^	19
SP1:
SP2:
SP3:																							-
SP4:																							-
SP5:

ECgene alternative splicing isoforms for EPHB6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

EPHB6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGGACGTGA

About this image

EPHB6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See EPHB6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EPHB6

SOURCE GeneReport for Unigene cluster: Hs.380089

UniProtKB/Swiss-Prot: EPHB6_HUMAN, O15197

Tissue specificity: Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level).

Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver,

skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is

expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not

detected in normal tissues

SABiosciences Custom PCR Arrays for EPHB6

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for EPHB6 gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	EPHB6¹	EPH receptor B6	62.43(n) 60.51(a)		418308 NM_001004387.1 NP_001004387.1
lizard (Anolis carolinensis)	Reptilia	EPHB6⁶	--	55(a)	1 ↔ 1	GL343499.1(174954-235855)
zebrafish (Danio rerio)	Actinopterygii	si:dkey-26c10.6⁶ CABZ01084877.1⁶ (see all 3)	--	45(a) 27(a) (see all 3)	1 ↔ 1 possible ortholog (see all 3)	16(14081915-14220460) Zv9_NA779(312-23840)
fruit fly (Drosophila melanogaster)	Insecta	Eph⁶	Eph receptor tyrosine kinase	28(a)	1 → many	4(631310-643096)
worm (Caenorhabditis elegans)	Secernentea	vab-1⁶ W03A5.1⁶ (see all 6)	--	24(a) 13(a) (see all 6)	possible ortholog possible ortholog (see all 6)	II(4571997-4591357) III(5408047-5413138)

ENSEMBL Gene Tree for EPHB6 (if available)
TreeFam Gene Tree for EPHB6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for EPHB6 gene

EPHB1² EPHA2² EPHB3² EPHA4² EPHA5² EPHA6² EPHB2² EPHA1²

EPHA8² EPHA3² EPHA7² EPHB4² EPHA10²

18/27 SIMAP similar genes for EPHB6 using alignment to 4 protein entries: EPHB6_HUMAN (see all proteins) (see all similar genes):

EPHB2 variant protein EPHA6 EPHB3 EPHB2 EPHA4 EPHB1

EPHA7 EPHA3 EPHA2 FGR EPHB4 EPHA8

TXK EPHA5 FES tec EPHA10 BTK kinase deficient isoform 2

EPHB6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191431540^1,2		--	142550888(+)	`AATTAA/GGATGC`	1	--	us2k¹		0	--	--	--	--
rs8177090^1,2	C,F,H,	--	142551004(+)	`TTACAC/TAAGCC`	1	--	us2k¹		18		NS EA NA WA	1828
rs8177167^1,2	C,	--	142551031(+)	`TCATTT/ACATAT`	1	--	us2k¹		3		NS NA	94
rs187032368^1,2		--	142551080(+)	`AGAAGA/GCAGAT`	1	--	us2k¹		0	--	--	--	--
rs190392552^1,2		--	142551115(+)	`GATACA/GTTGCA`	1	--	us2k¹		0	--	--	--	--
rs8177091^1,2	C,F,	--	142551211(+)	`TGTGTC/ATTTTT`	1	--	us2k¹ trp³		3		NS WA	210
rs148939240^1,2		--	142551277(+)	`GTTACA/GTAATT`	1	--	us2k¹		0	--	--	--	--
rs75316911^1,2	C	--	142551363(+)	`CCTCCA/TCCACT`	1	--	us2k¹		0	--	--	--	--
rs8177092^1,2	C,F,H,	--	142551398(+)	`CAAGAT/AAAAGT`	1	--	us2k¹ tfbs³		7		NS EA WA	620
rs8177093^1,2	C,H	--	142551422(+)	`CAAGTG/AGAATT`	1	--	us2k¹ tfbs³		8		NS EA NA	508

HapMap Linkage Disequilibrium report for EPHB6 (142552792 - 142568847 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for EPHB6
1 CNV: 52134
Human Gene Mutation Database (HGMD): EPHB6

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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EPHB6 for disorders           About GeneDecksing

OMIM gene information: 602757 141400 605635
20/22 diseases for EPHB6 (see all 22):    About MalaCards

anaplastic astrocytoma gliosarcoma chronic lymphocytic leukemia lymphocytic leukemia

familial colorectal cancer malignant glioma colorectal cancer astrocytoma

lung adenocarcinoma melanoma breast carcinoma prostate carcinoma

leukemia lung cancer adenocarcinoma breast cancer

glioblastoma carcinoma neuroblastoma prostatitis

1 disease from the University of Copenhagen DISEASES database for EPHB6:

Neuroblastoma

4 Novoseek disease relationships for EPHB6 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
melanoma	29.2	10	14612926 (5), 20181626 (1), 15147954 (1)
metastasis	27.2	6	14612926 (4), 19513565 (1)
cancer	11.4	4	20181626 (1), 14612926 (1), 15147954 (1)
tumors	10.6	4	10984508 (1), 20181626 (1), 14612926 (1)

Human Genome Epidemiology (HuGE) Navigator: EPHB6 (2 documents)

Export disorders for EPHB6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for EPHB6 gene, integrated from 9 sources (see all 51):
(articles sorted by number of sources associating them with EPHB6)

Utopia: connect your pdf to the dynamic
world of online information

Biphasic functions of the kinase-defective Ephb6 receptor in cell adhesion and migration. (PubMed id 15955811)^{1, 2, 9} Matsuoka H.... Nakamoto M. (2005)
Expression of a kinase-defective Eph-like receptor in the normal human brain. (PubMed id 9207182)^{1, 2, 9} Matsuoka H.... Matsui T. (1997)
EphB6 receptor significantly alters invasiveness and other phenotypic characteristics of human breast carcinoma cells. (PubMed id 19234485)^{1, 2} Fox B.P. and Kandpal R.P. (2009)
Erythropoietin-producing hepatocyte B6 variant-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in human leukocyte antigen-A2+ glioma patients. (PubMed id 18754880)^{1, 2} Jin M....Yamada A. (2008)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2} Scherer S.W.... Tsui L.-C. (2003)
The EphB6 receptor inhibits JNK activation in T lymphocytes and modulates T cell receptor-mediated responses. (PubMed id 12517763)^{1, 2} Freywald A.... Roifman C.M. (2003)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1. (PubMed id 11713248)^{1, 2} Freywald A....Roifman C.M. (2002)
Loss of EphB6 expression in metastatic melanoma. (PubMed id 14612926)^{1, 9} Hafner C....Vogt T. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2051	HGNC: 3396	AceView: EPHB6	Ensembl:ENSG00000106123	euGenes: HUgn2051
ECgene: EPHB6	Kegg: 2051	H-InvDB: EPHB6

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for EPHB6	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for EPHB6	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/ephb6/

Intellectual Property for EPHB6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for EPHB6 gene:
Search GeneIP for patents involving EPHB6

GeneCards and IP:
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