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EPHB6 Gene

protein-coding GIFtS: 65

GC07P142262

EPH receptor B6
(Previous name: EphB6 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
EphB6 ^¹
HEP ^¹, ², ³, ⁵
MGC129910 ^²
MGC129911 ^²

Descriptions
EPH receptor B6 ^²
Tyrosine-protein kinase-defective receptor EPH-6 ^³
ephrin receptor EphB6 ^²

External Ids
HGNC: 3396¹
Entrez Gene: 2051²
UniProtKB: O15197³
Ensembl: ENSG00000106123⁷

Search outside databases for aliases for EPHB6 gene

Previous GC identifers: GC07P140878 GC07P141946 GC07P142023 GC07P142069

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for EPHB6:

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes,

particularly in the nervous system. Based on their structures and sequence relationships, ephrins

are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a

glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane

proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their

extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.

Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The

ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases

and binds to ephrin-B ligands. [provided by RefSeq]

UniProtKB/Swiss-Prot: EPHB6_HUMAN, O15197

Function: Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and

ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects

upon stimulation with ephrin-B2. Inhibits JNK activation, T cell receptor-induced IL-2 secretion

and CD25 expression upon stimulation with ephrin-B2

Gene Wiki entry for EPHB6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the EPHB6 gene

Entrez Gene cytogenetic band: 7q33-q35 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q33-q35

EPHB6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P142262: (about GC identifiers)

Start:	142,262,914 bp from pter
End:	142,278,969 bp from pter
Size:	16,056 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 141,954,656-141,970,711

RefSeq DNA sequence:

NC_000007.12 NT_007914.14 NT_079596.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: EPHB6_HUMAN, O15197 (See protein sequence)

Recommended Name: Ephrin type-B receptor 6 precursor

Size: 1006 amino acids; 109273 Da

Subunit: Interacts with CBL and EPHB1. Interacts with FYN; this interaction takes place in a

ligand-independent manner

Subcellular location: Membrane; Single-pass type I membrane protein

Subcellular location: Isoform 3: Secreted (Probable)

Secondary accessions: A4D2I7 A8CDT5 Q2TB23 Q2TB24

Alternative splicing: 3 isoforms: O15197-1 O15197-2 O15197-3

Post-translational modifications:

Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues

is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent

manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition

from cell adhesion/attraction to de-adhesion/repulsion¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004436.2

ENSEMBL proteins:

ENSP00000376684 ENSP00000222847

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for EPHB6
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Eph receptor B6)
	Human Recombinant Proteins from Abnova (EPHB6)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for EPHB6:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for EPHB6
	R&D Systems Antibodies for EPHB6
	Antibodies from Abcam (Eph receptor B6), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (EPHB6)
	Novus Biologicals Antibodies for EPHB6

Assays for EPHB6:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O15197

ProtoNet protein and cluster: O15197

5 Blocks protein families:

IPB001090 Ephrin receptor

IPB001426 Receptor tyrosine kinase

IPB001660 Sterile alpha motif SAM

IPB003962 Fibronectin type III repeat signature

IPB011510 Sterile alpha motif homology 2

UniProtKB/Swiss-Prot: EPHB6_HUMAN, O15197

Domain: The protein kinase domain is predicted to be catalytically inactive. Its extracellular

domain is capable of promoting cell adhesion and migration in response to low concentrations of

ephrin-B2, but its cytoplasmic domain is essential for cell repulsion and inhibition of migration

induced by high concentrations of ephrin-B2

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor

subfamily

Similarity: Contains 2 fibronectin type-III domains

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 SAM (sterile alpha motif) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EPHB6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EPHB6)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004445

Applied Biosystems Silencer® siRNAs for EPHB6

Sigma-Aldrich siRNA and siRNA Panels for EPHB6

Sigma-Aldrich shRNA Panels and shRNA for EPHB6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004445
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004445
untagged cDNA clones in CMV expression vector (see all 2): NM_004445

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004445

UniProtKB/Swiss-Prot: EPHB6_HUMAN, O15197

Function: Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and

ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects

upon stimulation with ephrin-B2. Inhibits JNK activation, T cell receptor-induced IL-2 secretion

and CD25 expression upon stimulation with ephrin-B2

Genatlas biochemistry entry for EPHB6:

EPH-related tyrosine kinase receptor,135kDa,binding ephrin B6,expressed in projecting neurons and

their target fields,involved in short-range contact-mediated axonal guidance

12 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Ephb6):

behavior/neurological	digestive/alimentary	growth/size	hematopoietic system	homeostasis/metabolism
immune system	normal	renal/urinary system	reproductive system	skeleton
skin/coat/nails	tumorigenesis

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004713	protein tyrosine kinase activity	IEA	--
GO:0004872	receptor activity	TAS	9207182
GO:0005003	ephrin receptor activity	TAS	10984508
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for EPHB6 (Your Favorite Gene powered by Ingenuity)

Axonal Guidance Signaling
Ephrin Receptor Signaling

GeneDecks EPHB6 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for EPHB6

5/20 Interacting proteins for EPHB6 (O15197² ENSP00000222847³) via UniProtKB, MINT, and/or STRING (see all 20 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MLLT4	P55196², ENSP00000252692³	MINT-58217 STRING (score=.732)
SAT1	P21673²	MINT-63555
EFNB2	ENSP00000245323³	STRING (score=.989)
EFNB3	ENSP00000226091³	STRING (score=.977)
EFNB1	ENSP00000204961³	STRING (score=.946)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	IEA	--
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for EPHB6
1 Novoseek chemical compound relationship for EPHB6 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	41.68	5	15955811 (3), 11466354 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (EPHB6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (EPHB6)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004445

Sigma-Aldrich siRNA and siRNA Panels for EPHB6

Sigma-Aldrich shRNA Panels and shRNA for EPHB6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004445

REFSEQ mRNAs for EPHB6 gene:

NM_004445.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004445

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004445
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004445
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004445

Additional cDNA sequence:

BC015495.1 BC047892.1 BC051028.1 BC056159.1 BC110606.1 BC110607.1 D83492.1 EU054308.1

12 DOTS entries:

DT.313090 DT.91679781 DT.75106766 DT.99959485 DT.100678843 DT.95108033 DT.100019851 DT.102821285

DT.121076990 DT.100022150 DT.100816445 DT.121076810

7 AceView cDNA sequences:

BC056159 AL832533 BC051028 NM_004445 D83492 BC047892 BC015495

highest scoring ESTs for EPHB6:

D83492 BC047892 BC051028 BC056159 BX415689 AA351300 AA609284 AA815237 AA913460 AA984196

Unigene Cluster for EPHB6:

EPH receptor B6

Hs.380089 [show with all ESTs]

Unigene Representative Sequence: BC051028

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for EPHB6 (see all 7 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b	·	11c	^	12	^	13	^	14a	·	14b	^	15	^	16a	·	16b	^	17	^	18	^	19
SP1:
SP2:
SP3:																							-
SP4:																							-
SP5:

About this scheme

ECgene alternative splicing isoforms for EPHB6

2 Ensembl transcripts including schematic representations:

ENST00000392957 ENST00000222847

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

EPHB6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for EPHB6

¹ / ² / ³

3 probe-sets matching EPHB6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39930_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	D83492	1.00	1.00	1.00	1
204718_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004445	0.60	1.00	0.82	1
204718_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks EPHB6 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGGGACGTGA

SOURCE GeneReport for Unigene cluster: Hs.380089
Expression variation in blood from EXPOLDB for EPHB6
UniProtKB/Swiss-Prot: EPHB6_HUMAN, O15197
Tissue specificity: Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at
protein level). Strong expression in brain and pancreas, and weak expression in other tissues,
such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive
tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas,
anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal
tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for EPHB6 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	EPHB6¹	--	EPH receptor B6	88.9(n) 93.38(a)	475519 XM_532743.2 XP_532743.2
chimpanzee (Pan troglodytes)	EPHB6¹	--	EPH receptor B6	99.57(n) 99.5(a)	463799 XM_519443.2 XP_519443.2
cow (Bos taurus)	EPHB6¹	--	EPH receptor B6	87.43(n) 92.94(a)	529800 XM_608259.3 XP_608259.3
rat (Rattus norvegicus)	Ephb6¹	--	Eph receptor B6	86.57(n) 92.79(a)	312275 XM_231650.4 XP_231650.3
mouse (Mus musculus)	Ephb6^{1, 5}	6⁵	Eph receptor B6^{1, 5}	86.97(n)¹ 93.09(a)¹	13848¹ NM_007680.3¹ NP_031706.2¹ AF336378⁵ AK076442⁵ (see all 15)

About this table Species with no ortholog for EPHB6

ENSEMBL Gene Tree for EPHB6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for EPHB6 gene

TNK1² EPHB4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/182 NCBI SNPs in EPHB6 are shown (see all 182 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 98)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs7789029^1,2	A,C,F,H	142262495(+)	`AGTTCA/CAAGCT`	1	--	ng5¹		6	NS EU EA WA	486
	rs8177146^1,2	C,F,H	142273375(+)	`ATAAGT/GCTTCT`	1	A/S	mis¹ ese³		12	NS EU EA WA	1162
	rs8177090^1,2	C,F,H	142261126(+)	`TTACAC/TAAGCC`	1	--	ng5¹		10	NS EU EA WA	926
--	rs8177098^1,2	C,F	142262455(+)	`CTTTTC/TCTTCC`	1	--	ng5¹ tfbs³ trp³		8	NS	728
	rs8177095^1,2	F,H	142261957(+)	`CAAGGC/GCCCAG`	1	--	ng5¹ tfbs³		4	NS EU WA	330
--	rs8177094^1,2	C,F	142261721(+)	`ACTCTTACT/- GAGTT`	1	--	ng5¹		2	NS	86
--	rs8177125^1,2	C,F	142269013(+)	`CTCTAG/AATCAA`	1	--	ut5¹		2	NS	86
	rs8177092^1,2	F,H	142261520(+)	`CAAGAT/AAAAGT`	1	--	ng5¹ tfbs³		6	NS EU EA WA	502
--	rs7789303^1,2	C,F	142262669(+)	`GCAGGA/GGCTTT`	1	--	ng5¹		8	NS	722
--	rs8177175^1,2	H	142274394(+)	`GAGCCG/AGGCAT`	1	Q/R	mis¹ ese³		6	NS EU EA WA	492

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HapMap Linkage Disequilibrium images for EPHB6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602757

4 Novoseek disease relationships for EPHB6 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
melanoma	19.14	9	14612926 (5), 15147954 (1)
tumors	6.97	3	10984508 (1), 14612926 (1)
cancer	6.85	3	14612926 (1), 15147954 (1)
metastasis	0.26	5	14612926 (4)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/37 PubMed articles for EPHB6 gene (see all 37 ):

Biphasic functions of the kinase-defective Ephb6 receptor in cell adhesion and migration. (PubMed id 15955811)^{1, 3, 4} Matsuoka H....Nakamoto M. (2005)
Expression of a kinase-defective Eph-like receptor in the normal human brain. (PubMed id 9207182)^{1, 3, 4} Matsuoka H.... Matsui T. (1997)
EphB6 receptor significantly alters invasiveness and other phenotypic characteristics of human breast carcinoma cells. (PubMed id 19234485)^{3, 4} Fox B.P. and Kandpal R.P. (2009)
Erythropoietin-producing hepatocyte B6 variant-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in human leukocyte antigen-A2+ glioma patients. (PubMed id 18754880)^{3, 4} Jin M....Yamada A. (2008)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{3, 4} Zhang Z. and Henzel W.J. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{3, 4} Scherer S.W....Tsui L.C. (2003)
The EphB6 receptor inhibits JNK activation in T lymphocytes and modulates T cell receptor-mediated responses. (PubMed id 12517763)^{3, 4} Freywald A....Roifman C.M. (2003)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{3, 4} Hillier L.W.... Wilson R.K. (2003)
The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1. (PubMed id 11713248)^{3, 4} Freywald A....Roifman C.M. (2002)
Loss of EphB6 expression in metastatic melanoma. (PubMed id 14612926)^{1, 3} Hafner C....Vogt T. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2051	HGNC: 3396	AceView: EPHB6	Ensembl:ENSG00000106123	euGenes: HUgn2051
ECgene: EPHB6	H-InvDB: EPHB6

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for EPHB6	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/ephb6/

Licensable Technologies for EPHB6
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for EPHB6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for EPHB6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for EPHB6		Antibodies for EPHB6
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for EPHB6		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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EPHB6 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for EPHB6

Summaries
for EPHB6

Genomic Location
for EPHB6

Proteins
for EPHB6

Protein Domains/
Families
for EPHB6

Gene Function
for EPHB6

Pathways & Interactions
for EPHB6

Drugs & Compounds
for EPHB6

Transcripts
for EPHB6

Expression
for EPHB6

Orthologs
for EPHB6

Paralogs
for EPHB6

SNPs/Variants
for EPHB6

Disorders & Mutations
for EPHB6

Medical News
for EPHB6

Publications
for EPHB6

Search for EPHB6

Genome Databases showing EPHB6

Other Databases showing EPHB6

Specialized Databases showing EPHB6

Licensable Technologies
for EPHB6

Services
for EPHB6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

EPHB6 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor EPHB6

Summariesfor EPHB6

Genomic Locationfor EPHB6

Proteinsfor EPHB6

Protein Domains/Familiesfor EPHB6

Gene Functionfor EPHB6

Pathways & Interactionsfor EPHB6

Drugs & Compoundsfor EPHB6

Transcriptsfor EPHB6

Expression for EPHB6

Orthologsfor EPHB6

Paralogsfor EPHB6

SNPs/Variantsfor EPHB6

Disorders & Mutationsfor EPHB6

Medical Newsfor EPHB6

Publicationsfor EPHB6

Search for EPHB6

Genome Databases showing EPHB6

Other Databases showing EPHB6

Specialized Databases showing EPHB6

Licensable Technologiesfor EPHB6

Servicesfor EPHB6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for EPHB6

Summaries
for EPHB6

Genomic Location
for EPHB6

Proteins
for EPHB6

Protein Domains/
Families
for EPHB6

Gene Function
for EPHB6

Pathways & Interactions
for EPHB6

Drugs & Compounds
for EPHB6

Transcripts
for EPHB6

Expression
for EPHB6

Orthologs
for EPHB6

Paralogs
for EPHB6

SNPs/Variants
for EPHB6

Disorders & Mutations
for EPHB6

Medical News
for EPHB6

Publications
for EPHB6

Licensable Technologies
for EPHB6

Services
for EPHB6