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EPHB4 Gene

protein-coding   GIFtS: 73
GCID: GC07M100402

EPH Receptor B4

(Previous name: EphB4)
(Previous symbol: HTK)
  See EPHB4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
EPH Receptor B41 2     Ephrin Receptor EphB42
HTK1 2 3 5     Ephrin Type-B Receptor 42
MYK12 3 5     Soluble EPHB4 Variant 12
Hepatoma Transmembrane Kinase2 3     Soluble EPHB4 Variant 22
Tyrosine-Protein Kinase TYRO112 3     Soluble EPHB4 Variant 32
TYRO112 3     Tyrosine-Protein Kinase Receptor HTK2
EC 2.7.10.13 8     EC 2.7.108
EphB41     

External Ids:    HGNC: 33951   Entrez Gene: 20502   Ensembl: ENSG000001964117   OMIM: 6000115   UniProtKB: P547603   

Export aliases for EPHB4 gene to outside databases

Previous GC identifers: GC07M098934 GC07M099997 GC07M100011 GC07M100044 GC07M100238 GC07M095030


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EPHB4 Gene:
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the
nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A
(EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B
(EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on
the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B
ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein
encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. (provided by RefSeq,
Jul 2008)

GeneCards Summary for EPHB4 Gene:
EPHB4 (EPH receptor B4) is a protein-coding gene. Diseases associated with EPHB4 include prostate cancer. GO annotations related to this gene include ephrin receptor activity and transmembrane receptor protein tyrosine kinase activity. An important paralog of this gene is EPHB1.

UniProtKB/Swiss-Prot: EPHB4_HUMAN, P54760
Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on
adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2
plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell
migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing
cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus
important in the context of tumor angiogenesis

summary for EPHB4 Gene:
Ephrins are a family of receptor tyrosine kinases (RTKs) that influence cell migration. In conjunction with
the ephrin ligands, ephrin receptors are involved in a variety of developmental events. EphB4 is
overexpressed in many tumor types, including breast and prostate cancer.

Gene Wiki entry for EPHB4 (EPH receptor B4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the EPHB4 gene promoter:
         AP-2rep   AREB6   p53   AP-1   p300   Lmo2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEPHB4 promoter sequence
   Search Chromatin IP Primers for EPHB4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EPHB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22

EPHB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHB4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M100402:  view genomic region     (about GC identifiers)

Start:
100,400,187 bp from pter      End:
100,425,143 bp from pter
Size:
24,957 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 99,759,792-99,784,748     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: EPHB4_HUMAN, P54760 (See protein sequence)
Recommended Name: Ephrin type-B receptor 4 precursor  
Size: 987 amino acids; 108270 Da
Subunit: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a
receptor dimer. Oligomerization is probably required to induce biological responses (By similarity)
Developmental stage: Expressed in fetal heart, lung, liver and to a lower extent in brain. Not expressed in adult
brain
Selected PDB 3D structures from and Proteopedia for EPHB4 (see all 18):
2BBA (3D)        2E7H (3D)        2HLE (3D)        2QKQ (3D)        2VWU (3D)        2VWV (3D)    
Secondary accessions: Q9BTA5 Q9BXP0

Explore the universe of human proteins at neXtProt for EPHB4: NX_P54760

Explore proteomics data for EPHB4 at MOPED

Post-translational modifications: 

  • Phosphorylated; autophosphorylation is stimulated by EFNB21
  • Glycosylation2 at Asn203, Asn335, Asn426
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for EPHB4 (P54760) (see all 25)
     MSNQDVI  RDLAARN  SDPTYTS  QLMLDCW 


    See EPHB4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004435.3  
    ENSEMBL proteins: 
     ENSP00000353833   ENSP00000350896  

    EPHB4 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for EPHB4
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    Novus Biologicals EPHB4 Proteins
    Novus Biologicals EPHB4 Lysate
    Browse Sino Biological Recombinant Proteins
    Sino Biological Cell Lysate for EPHB4
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EPHB4

     
    Search eBioscience for Proteins for EPHB4 

     
    antibodies-online proteins for EPHB4 (7 products) 

     
    antibodies-online peptides for EPHB4

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    antibodies-online antibodies for EPHB4 (101 products) 

    EPHB4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for EPHB4
    Cloud-Clone Corp. CLIAs for EPHB4
    Search eBioscience for ELISAs for EPHB4 
    antibodies-online kits for EPHB4 (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    EPH: EPH receptors
    SAMD: Sterile alpha motif (SAM) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: EPH receptor B4
    Ephrin receptor family
    Ephrin receptor family

    Selected InterPro protein domains (see all 18):
     IPR017441 Protein_kinase_ATP_BS
     IPR003961 Fibronectin_type3
     IPR021129 SAM_type1
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P54760

    ProtoNet protein and cluster: P54760

    5 Blocks protein domains:
    IPB001090 Ephrin receptor
    IPB001426 Receptor tyrosine kinase
    IPB001660 Sterile alpha motif SAM
    IPB003962 Fibronectin type III repeat signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EPHB4_HUMAN, P54760
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Find genes that share domains with EPHB4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EPHB4_HUMAN, P54760
    Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on
    adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
    pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
    the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2
    plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell
    migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing
    cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus
    important in the context of tumor angiogenesis
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for EPHB4:
    EPH-related tyrosine kinase receptor,binding ephrin B4,expressed in projecting neurons and their target
    fields,involved in short-range contact-mediated axonal guidance,also involved in angiogenesis by marking venous
    but not arterial endothelial cells

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity IDA8188704
    GO:0005003ephrin receptor activity IDA12734395
    GO:0005515protein binding IPI16867992
         
    Find genes that share ontologies with EPHB4           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for EPHB4:
     Decreased focal adhesion (FA)   Increased cell death in HCT116  Increased colony dispersion (i 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ephb4):
     cardiovascular system  embryogenesis  growth/size/body  mortality/aging  muscle 

    Find genes that share phenotypes with EPHB4           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EPHB4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EPHB4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EPHB4

    miRNA
    Products:
        
    miRTarBase miRNAs that target EPHB4:
    hsa-mir-20b-5p (MIRT006338), hsa-mir-1260b (MIRT052757), hsa-mir-93-3p (MIRT038783), hsa-mir-335-5p (MIRT017978)

    Block miRNA regulation of human, mouse, rat EPHB4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EPHB4 (see all 39):
    hsa-miR-300 hsa-miR-106a hsa-miR-3653 hsa-miR-624 hsa-miR-301a hsa-miR-519a hsa-miR-124 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidEPHB4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat EPHB4

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: EPHB4 (NM_004444)
    Sino Biological Human cDNA Clone for EPHB4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHB4
    Addgene plasmids for EPHB4 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHB4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EPHB4_HUMAN, P54760: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytoskeleton1
    cytosol1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane IDA8188704

    Find genes that share ontologies with EPHB4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EPHB4 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    Ephrin-Eph Signaling0.58
    2EPHB forward signaling
    EPHB forward signaling0.30
    EphrinB-EPHB pathway0.00
    Cell adhesion Ephrins signaling0.30
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48


    Find genes that share SuperPaths with EPHB4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EPHB4 (see all 31)
        MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Ephrin-Eph Signaling

    2 GeneGo (Thomson Reuters) Pathways for EPHB4
        Cytoskeleton remodeling Reverse signaling by ephrin B
    Cell adhesion Ephrins signaling

    3 BioSystems Pathways for EPHB4
        Ephrin B reverse signaling
    EPHB forward signaling
    EphrinB-EPHB pathway



    1 Kegg Pathway  (Kegg details for EPHB4):
        Axon guidance

        Pathway & Disease-focused RT2 Profiler PCR Array including EPHB4: 
              Angiogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for EPHB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for EPHB4 (P547603 ENSP000003508964) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRIN1Q055863, ENSP000003606164I2D: score=2 STRING: ENSP00000360616
    SDC3O750563, ENSP000003444684I2D: score=2 STRING: ENSP00000344468
    EFNB2P527993, ENSP000002453234I2D: score=1 STRING: ENSP00000245323
    JUNP054123, ENSP000003602664I2D: score=1 STRING: ENSP00000360266
    EGFRP005333, ENSP000002754934I2D: score=1 STRING: ENSP00000275493
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis ISS--
    GO:0002042cell migration involved in sprouting angiogenesis IDA12734395
    GO:0003007heart morphogenesis ISS--
    GO:0006468protein phosphorylation ----
    GO:0007155cell adhesion IDA12734395

    Find genes that share ontologies with EPHB4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for EPHB4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GTP 14564Class III receptor tyrosine kinase (RTK) inhibitor[34823-86-4]
    NVP BHG 712Potent EphB4 kinase inhibitor[940310-85-0]
    Ki 20227c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation[623142-96-1]

    2 HMDB Compounds for EPHB4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    8 DrugBank Compounds for EPHB4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3-({4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZAMIDE-- --target--10592235
    3-({4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzenesulfonamide-- --target--10592235
    N'-(3-CHLORO-4-METHOXY-PHENYL)-N-(3,4,5-TRIMETHOXYPHENYL)-1,3,5-TRIAZINE-2,4-DIAMINE-- --target--10592235
    N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3,4,5- TRIMETHOXYPHENYL)PYRIMIDINE-2,4-DIAMINE-- --target--10592235
    N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3-MORPHOLIN-4-YLPHENYL)PYRIMIDINE-2,4-DIAMINE-- --target--10592235
    N'-(5-chloro-1,3-benzodioxol-4-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine-- --target--10592235
    N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine-- --target--10592235
    N-[3-[[4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL]AMINO]PHENYL]METHANESULFONAMIDE-- --target--10592235

    3 Novoseek inferred chemical compound relationships for EPHB4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 66 35 8188704 (4), 10221518 (3), 15358160 (2), 16816380 (2) (see all 16)
    vegf 40.8 10 20338920 (3), 19950560 (1), 19923070 (1), 15471957 (1) (see all 6)
    thymidine 38.9 9 7593001 (2), 7969135 (1), 10502302 (1), 10639574 (1) (see all 6)



    Find genes that share compounds with EPHB4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EPHB4 gene: 
    NM_004444.4  

    Unigene Cluster for EPHB4:

    EPH receptor B4
    Hs.437008  [show with all ESTs]
    Unigene Representative Sequence: AB209644
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360620 ENST00000358173(uc003uwn.1 uc010lhj.1 uc011kkf.1 uc011kkg.1 uc011kkh.1)
    ENST00000487222(uc003uwm.1) ENST00000492403 ENST00000478459 ENST00000467515
    ENST00000477446 ENST00000489808 ENST00000492878
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate EPHB4 (see all 39):
    hsa-miR-300 hsa-miR-106a hsa-miR-3653 hsa-miR-624 hsa-miR-301a hsa-miR-519a hsa-miR-124 hsa-miR-9
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    GenScript: all cDNA clones in your preferred vector: EPHB4 (NM_004444)
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    Addgene plasmids for EPHB4 
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      QuantiTect SYBR Green Assays in human, mouse, rat EPHB4
      QuantiFast Probe-based Assays in human, mouse, rat EPHB4

    Additional mRNA sequence: 

    AB209644.1 AK301224.1 AY056048.1 BC004264.1 BC052804.1 EU826608.1 EU826609.1 EU826610.1 
    U07695.1 

    12 DOTS entries:

    DT.100689231  DT.100818782  DT.444136  DT.121068866  DT.100818780  DT.121068891  DT.95282899  DT.121068837 
    DT.97845932  DT.91914735  DT.95081702  DT.95282873 

    Selected AceView cDNA sequences (see all 188):

    BM929429 BM790755 BE466828 BM830054 AV708776 AW083751 BM823021 H89196 
    BM766839 AY056048 BM742052 AW276575 BM766176 BM756028 AA369508 BM757081 
    BM974102 BM857398 AA659141 BM852162 AA299650 BU683397 BM795543 AI270622 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EPHB4 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17
    SP1:              -                                               -                 -                                                               
    SP2:              -                                               -                 -                                                     -         
    SP3:                                                              -                 -                                                               
    SP4:                                                                                -                                                               
    SP5:                                                                                                  -                                             


    ECgene alternative splicing isoforms for EPHB4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    EPHB4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGTTTCCA
    EPHB4 Expression
    About this image


    EPHB4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 4 entries
             Venous Endothelial Cells Pulmonary Capillary Plexus
             Endothelial-like cells
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Venous Endothelial Cells Pulmonary Capillary Plexus
     
     Heart (Cardiovascular System)
             Venous Endothelial Cells Cardinal Veins
     
     NULL (Uncategorized)
             Endothelial-like cells
    EPHB4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EPHB4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437008

    UniProtKB/Swiss-Prot: EPHB4_HUMAN, P54760
    Tissue specificity: Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal
    muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in
    cell lines derived from liver, breast, colon, lung, melanocyte and cervix

        Pathway & Disease-focused RT2 Profiler PCR Array including EPHB4: 
              Angiogenesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for EPHB4
    OriGene qSTAR qPCR primer pairs in human, mouse for EPHB4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EPHB4
    QuantiTect SYBR Green Assays in human, mouse, rat EPHB4
    QuantiFast Probe-based Assays in human, mouse, rat EPHB4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHB4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for EPHB4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ephb41 , 5 Eph receptor B41, 5 86.47(n)1
    93.11(a)1
      5 (76.38 cM)5
    138461  NM_001159571.11  NP_001153043.11 
     1373501095 
    African clawed frog
    (Xenopus laevis)
    Amphibia ephB4a2 eph receptor tyrosine kinase 75.82(n)    AJ236867.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AJ005026.22   -- 78.6(n)   30688  AJ005026.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Eph3 protein amino acid phosphorylation
    transmembrane more
    38(a)
    (best of 2)
      102C2   --


    ENSEMBL Gene Tree for EPHB4 (if available)
    TreeFam Gene Tree for EPHB4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for EPHB4 gene
    EPHB12  EPHA22  EPHB32  EPHA42  EPHA52  EPHB62  EPHA62  EPHA12  
    EPHB22  EPHA82  EPHA32  EPHA72  EPHA102  
    Selected SIMAP similar genes for EPHB4 using alignment to 7 protein entries:     EPHB4_HUMAN (see all proteins) (see all similar genes):
    EPHB3    EPHB1    EPHB2 variant protein    EPHA2    EPHA3    EPHA4
    EPHA7    EPHB2    EPHA6    EPHA8    FRK    EPHA5
    HCK    YES1    EPHA10    EPHB6    LCK    LYN

    Find genes that share paralogs with EPHB4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for EPHB4 (see all 754)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0421884
    A gastric adenocarcinoma sample4--see VAR_0421882 R W mis40--------
    VAR_0421834
    A metastatic melanoma sample4--see VAR_0421832 P L mis40--------
    rs2004882591,2
    C--95055009(+) CCCCC-/CGCAAGG 1 -- int10--------
    rs1149419421,2
    C--100399695(+) CACACA/GTGGGG 1 -- ds50010--------
    rs746262601,2
    C,F--100399697(+) CACGTG/TGGGGG 1 -- ds50011Minor allele frequency- T:0.10WA 118
    rs117732811,2
    H--100399704(+) GGGGGG/TCCCTT 1 -- ds50010--------
    rs559822651,2
    C,F--100399802(+) TCCATC/TCACGG 1 -- ds50013Minor allele frequency- T:0.08WA NA EA 358
    rs1489635661,2
    --100399805(+) ATCCAC/TGGAAC 1 -- ds50010--------
    rs1909626041,2
    --100400105(+) TCCAGA/CCCTCT 1 -- ds50010--------
    rs559455031,2
    C--100400124(+) TCGGTA/C/GAGCCA 1 -- ds50015WA CSA NA EA 362
    rs1823823421,2
    --100400277(+) ACCGGC/TGTCCG 1 -- ut310--------
    rs1877509731,2
    --100400294(+) GGTTCC/TACCAC 1 -- ut310--------
    rs1436431191,2
    C--100400297(+) TCCACC/TACCAA 1 -- ut310--------
    rs1927413901,2
    --100400341(+) CTTCAC/TAGGAC 1 -- ut310--------
    rs1383159051,2
    --100400419(+) ATGATC/GATGGG 1 -- ut310--------
    rs37356931,2
    C,F,H--100400455(+) GGCCAT/CAGTGA 1 -- ut31 ese38Minor allele frequency- C:0.01EA NS NA 2164
    rs766008401,2
    C,F--100400516(+) ACGAAG/AAAACA 1 -- ut311Minor allele frequency- A:0.11WA 118
    rs1440575221,2
    --100400642(+) TGACAA/GCAGCA 1 -- ut310--------
    rs563263271,2
    C,F--100400654(+) GTTGGG/CACTAC 1 -- ut313Minor allele frequency- C:0.08WA NA EA 358
    rs1847302141,2
    --100400722(+) CCCCCA/CACTCT 1 -- ut310--------
    rs1469069331,2
    --100400731(+) CTGGAA/GCTGGC 1 -- ut310--------
    rs1883960011,2
    --100400769(+) GGGAAC/TGCACC 1 -- ut310--------
    rs1135761311,2
    C--100400944(+) GTCTC-/TCCAAAT 1 -- ut311Minor allele frequency- TC:0.00CSA 2
    rs1998725331,2
    --100401052(+) GGAGGC/TGGTGT 1 -- ut310--------
    rs1922943241,2
    --100401067(+) GGGGTA/GGGGAG 1 -- ut310--------
    rs560869101,2
    C--100401092(+) TACTGC/TGGGGC 2 P syn11Minor allele frequency- T:0.00NA 3362
    rs1128039971,2
    C,F--100401098(+) GGGGCC/AGGTCC 2 /P syn13Minor allele frequency- A:0.03CSA WA NA 3521
    rs1391960731,2
    C,F--100401183(+) GTCCCG/ACCAGA 2 /A /V mis11Minor allele frequency- A:0.00NA 4496
    rs3143481,2
    C,F,H--100401270(-) CCAAGC/AGAGGA 1 -- int1 trp320Minor allele frequency- A:0.07NS NA WA CSA EA 1398
    rs780697301,2
    C,F--100401408(+) CAGAAG/CGGGGT 1 -- int12Minor allele frequency- C:0.10CSA WA 119
    rs1894636721,2
    --100401409(+) AGAAGA/GGGGTA 1 -- int10--------
    rs2210051,2
    C,F,H--100401433(-) GGCCCT/CGCCTC 1 -- int113Minor allele frequency- C:0.18NS EA NA CSA WA 670
    rs24371011,2
    C,F,H--100401449(+) CTTGGG/ATGCCA 1 -- int15Minor allele frequency- A:0.02NS EA NA 520
    rs1924081061,2
    --100401554(+) AAGGCC/GGAAGT 1 -- int10--------
    rs1415202681,2
    --100401648(+) CCCCTA/GGGTCA 1 -- int10--------
    rs770938701,2
    C,F--100401650(+) CCTGGG/ATCAGA 1 -- int11Minor allele frequency- A:0.09WA 118
    rs1508889661,2
    --100401778(+) CATGCC/TCAGCT 1 -- int10--------
    rs3143491,2
    C,F,A--100401825(-) gccaaA/Catagc 1 -- int17Minor allele frequency- C:0.26NA WA EA 366
    rs25530221,2
    C,F,A,H--100401862(-) ACCGAT/CTGCTT 1 -- int15Minor allele frequency- C:0.21NA WA EA 362
    rs117716421,2
    C,H--100401878(+) tgagcC/Ttccca 1 -- int10--------
    rs113382931,2
    C--100401931(+) TTTTT-/TTTTTT 1 -- int1 trp32Minor allele frequency- T:0.25NA 4
    rs3143501,2
    C,F,A--100402000(-) gagatT/Cgcacc 1 -- int14Minor allele frequency- C:0.25NA 8
    rs584897771,2
    C,F--100402005(+) GATCTC/TGGCTC 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1844382171,2
    --100402022(+) ACCTCC/TACCTC 1 -- int10--------
    rs1892921731,2
    --100402040(+) CAAGCA/GATTCT 1 -- int10--------
    rs1812875541,2
    C--100402056(+) CTCAGC/TCTCCT 1 -- int10--------
    rs1867443051,2
    C--100402071(+) AGCTGA/GTATTA 1 -- int10--------
    rs558679081,2
    C--100402134(+) GTTTCA/CCCAAG 1 -- int10--------
    rs1886365211,2
    --100402202(+) AAAGTC/GCTGGC 1 -- int10--------
    rs1441298331,2
    --100402320(+) AAGGGC/GGAGTA 1 -- int10--------
    rs1460320571,2
    --100402405(+) AAGAGC/GATCTC 1 -- int10--------
    rs3143511,2
    C,F,H--100402442(+) TATGGG/TTGGAA 1 -- int124Minor allele frequency- T:0.05MN NS EA NA WA CSA 1761
    rs1817014991,2
    --100402467(+) TTGACA/GCATTG 1 -- int10--------
    rs25530211,2
    C,F,H--100402542(-) CCATCG/ACGCTT 1 -- int113Minor allele frequency- A:0.10NS EA NA 1062
    rs2014625171,2
    --100402740(+) GACTCC/TAGCTG 1 -- int10--------
    rs1138300851,2
    C--100402759(+) TCCCAT/GCCCCA 1 -- int11Minor allele frequency- G:0.33CSA 3
    rs2006882951,2
    C--100402838(+) GCTGCG/AAAACT 2 /F syn11Minor allele frequency- A:0.00EU 811
    rs1996742771,2
    C--100402842(+) CGAAAC/TTTTCT 2 N S mis10--------
    rs2009530301,2
    --100402918(+) CTGCCA/GCTGGT 2 R W mis10--------
    rs2007959961,2
    C--100402924(+) CTGGTC/GCAGGA 2 H D mis10--------
    rs1999812071,2
    C--100402961(+) GATGGA/GGAGGA 1 -- int10--------
    rs1467681921,2
    C--100403123(+) CTCACC/ACGCCA 2 /G /V mis11Minor allele frequency- A:0.00NA 4076
    rs1403322221,2
    C,F--100403124(+) TCACCC/TGCCAT 2 R G mis11Minor allele frequency- T:0.00NA 4074
    rs356383781,2,,4
    C,F--100403131(+) CCATTC/ATCCCG 2 /E /D mis14Minor allele frequency- A:0.01NA EU 5305
    rs1490618891,2
    C,F--100403143(+) GCCACG/AATTTT 2 /I syn11Minor allele frequency- A:0.01NA 4124
    rs349182251,2,,4
    C,F--100403157(+) GCTGGC/TGGGGT 2 T A mis14Minor allele frequency- T:0.01NA WA 4226
    rs2018424191,2
    --100403184(+) CAGGGC/TGCTGA 2 T A mis10--------
    rs1401358381,2
    C,F--100403286(+) GGGCAG/ACCGGT 2 /L syn11Minor allele frequency- A:0.00NA 4160
    rs1124108461,2
    C--100403317(+) ATCACG/CTGGAA 1 -- spa11Minor allele frequency- C:0.00CSA 1
    rs1129109341,2
    C--100403319(+) CACCTC/GGAAAG 1 -- int11Minor allele frequency- G:0.00CSA 1
    rs2001741841,2
    C--100403331(+) GGGGAA/CGAAGC 1 -- int11Minor allele frequency- C:0.00EU 1141
    rs2000172781,2
    --100403341(+) CTCTGC/GGTGAG 1 -- int10--------
    rs38470601,2
    C,F,H--100403429(-) ATTTTT/CTGGGG 1 -- int119Minor allele frequency- C:0.09NA NS EA WA 2478
    rs1911085821,2
    --100403439(+) TAACAC/GATCCA 1 -- int10--------
    rs1839074211,2
    --100403460(+) TAGCCA/GGAGTT 1 -- int10--------
    rs1133788471,2
    C,F--100403642(+) AATGGC/TGTGAT 1 -- int12Minor allele frequency- T:0.10CSA WA 120
    rs1860029981,2
    --100403708(+) CCTGAC/GTAGCT 1 -- int10--------
    rs1908593041,2
    --100403742(+) ATGCTA/GGGCTA 1 -- int10--------
    rs1825692891,2
    C--100403770(+) AGAGAA/CGGGGT 1 -- int10--------
    rs1512025941,2
    --100403781(+) TTCACC/TATGTT 1 -- int10--------
    rs3143521,2
    C,F,A--100403862(-) GCTCAA/TGCCTG 1 -- int16Minor allele frequency- T:0.09NA EA 130
    rs1159013971,2
    C,F--100403864(+) GGCTTG/AAGCCA 1 -- int11Minor allele frequency- A:0.09WA 118
    rs1404826901,2
    --100403982(+) CTTCAC/TCCCAA 1 -- int10--------
    rs2014324411,2
    C--100404031(+) ACCACG/AGGACA 1 -- int11Minor allele frequency- A:0.00EU 1321
    rs1884308941,2
    C--100404034(+) ACGGGA/GCACTT 1 -- int10--------
    rs1471107491,2
    C--100404052(+) GATTGC/TTCATG 2 N S mis11Minor allele frequency- T:0.00NA 4552
    rs2019290931,2
    C--100404069(+) TACGGC/TCTCTC 2 R syn10--------
    rs2011406011,2
    C--100404129(+) CTGGCA/GGAAGT 2 S syn10--------
    rs1500135191,2
    --100404305(+) AGGCCC/TCAAGC 1 -- int10--------
    rs781127051,2
    C,F--100404385(+) CCTCCC/TGGGTT 1 -- int11Minor allele frequency- T:0.03EA 120
    rs1436099331,2
    C--100404524(+) TGACCC/TCAGGC 1 -- int10--------
    rs1829830931,2
    --100404572(+) CAGGCA/GTGAGC 1 -- int10--------
    rs1423434131,2
    C--100404697(+) CTCCTA/GCCTCA 1 -- int10--------
    rs1464609921,2
    C--100404978(+) ACCCCC/TAGCAT 1 -- int10--------
    rs2003766921,2
    --100405069(+) CGAGGA/TTGCTG 2 N I mis10--------
    rs1995910061,2
    --100405143(+) ATGCCC/TGAGGC 2 S syn10--------
    rs1126134651,2
    F--100405170(+) CCCACG/AAGCTG 2 /L syn12Minor allele frequency- A:0.50CSA 4
    rs787914621,2
    C,F--100405249(+) CCCACC/TGTTCC 1 -- int11Minor allele frequency- T:0.09WA 118
    rs2017121571,2
    C--100405251(+) CACCGC/TTCCCC 1 -- int10--------
    rs2009467291,2
    --100405271(+) ACATC-/TTTTTT 1 -- int10--------
    rs1872772441,2
    --100405686(+) CTACAA/GTATCA 1 -- int10--------
    rs1925327521,2
    --100405945(+) AAATGA/GTCCTT 1 -- int10--------
    rs1393392131,2
    --100405981(+) GACTAC/TAGGTG 1 -- int10--------
    rs1490162541,2
    --100406019(+) CAAAGC/GGGTTT 1 -- int10--------
    rs1437530421,2
    C--100406108(+) CCTCCC/GAAGGT 1 -- int10--------
    rs3143531,2
    C,F,O,A,H--100406144(-) CGGGTT/CGCTCA 1 -- int122Minor allele frequency- C:0.37NS EA NA WA CSA 2344
    rs758810541,2
    C,F--100406207(+) TCTTGG/TACTAG 1 -- int11Minor allele frequency- T:0.03NA 120
    rs1481465681,2
    --100406291(+) AAGCCC/TAACCT 1 -- int10--------
    rs1171548221,2
    C,F--100406360(+) ATCCCG/ATATTC 1 -- int11Minor allele frequency- A:0.02NA 120
    rs801610921,2
    C,F--100406478(+) TCCCCG/ACTCAG 1 -- int11Minor allele frequency- A:0.09WA 118
    rs1855001921,2
    --100406511(+) CCAGAC/TGGTCA 1 -- int10--------
    rs1411862971,2
    --100406522(+) GGGTAC/TAGACC 1 -- int10--------
    rs1903670631,2
    --100406694(+) CTCCTC/GCTCTT 1 -- int10--------
    rs588380401,2
    C,F--100406901(+) TTTTTG/ATATTT 1 -- int12Minor allele frequency- A:0.50WA CSA 4
    rs3143541,2
    C,F,A--100406915(-) cctgtT/Ctgtac 1 -- int15Minor allele frequency- C:0.40NA 10
    rs1423396211,2
    --100407068(+) TCCAGC/TGGGTT 1 -- int10--------
    rs1145428211,2
    F--100407139(+) GCTGGT/CCTTCC 1 -- int11Minor allele frequency- C:0.01WA 118
    rs2010396051,2
    --100407146(+) TCCCA-/TCTCTCT 1 -- int10--------
    rs1927940161,2
    --100407168(+) AGAGAC/TGGGAT 1 -- int10--------
    rs748275871,2
    C,F--100407416(+) CAGGTG/ATGTGT 1 -- int11Minor allele frequency- A:0.05EA 120
    rs1842503131,2
    --100407557(+) ATGGCA/GAAGCC 1 -- int10--------
    rs1459491501,2
    --100407603(+) TAGTGG/TCTCAT 1 -- int10--------
    rs1115802571,2
    C,F--100407699(+) AAACCG/CTGTCT 1 -- int12Minor allele frequency- C:0.50WA CSA 4
    rs1887793821,2
    --100407754(+) GTAGTC/TCCAGC 1 -- int10--------
    rs1445262791,2
    C--100407803(+) GGAGGC/TGGAGG 1 -- int10--------
    rs1446034621,2
    --100407993(+) GACATA/TCAGGC 1 -- int10--------
    rs1512557241,2
    --100407994(+) ACATTC/GAGGCG 1 -- int10--------
    rs1405897691,2
    C--100407998(+) TCAGGC/TGGACA 1 -- int10--------
    rs1504875881,2
    --100408102(+) CTCACA/GCCTGT 1 -- int10--------
    rs1811528081,2
    --100408170(+) ACCAGC/GCTGGG 1 -- int10--------
    rs1382510731,2
    --100408234(+) GTGGTA/GTGCAC 1 -- int10--------
    rs24661651,2
    C,F--100408386(+) AAATAT/CATATA 1 -- int11Minor allele frequency- C:0.05NA 120
    rs1491931101,2
    C--100408407(+) ACAAAA/GCCCGG 1 -- int10--------
    rs785246161,2
    F--100408410(+) AAGCCC/AGGTCT 1 -- int11Minor allele frequency- A:0.01WA 118
    rs1861451511,2
    --100408479(+) GAAACA/GTGAAA 1 -- int10--------
    rs1889201141,2
    --100408493(+) AACTGA/GGTATT 1 -- int10--------
    rs1451354611,2
    --100408506(+) ATGACA/GCTAGG 1 -- int10--------
    rs1821502911,2
    --100408517(+) GAATCA/GCTATA 1 -- int10--------
    rs1876705211,2
    --100408531(+) CTGTTC/TAATGC 1 -- int10--------
    rs1379263671,2
    --100408558(+) ATAGAA/CAAATG 1 -- int10--------
    rs1919425541,2
    --100408626(+) CAGCAC/TTTTGA 1 -- int10--------
    rs1424837041,2
    --100408698(+) GAAACC/GCTGTC 1 -- int10--------
    rs1445834991,2
    --100408720(+) TACAAA/CCATCA 1 -- int10--------
    rs58861401,2
    C,F--100408748(+) ATGCCA/-TGCAA 1 -- int14Minor allele frequency- -:0.38NA CSA 8
    rs24061461,2
    C,F--100408751(-) GAATTA/GCATGG 1 -- int15Minor allele frequency- G:0.30NA WA 10
    rs1850006141,2
    --100408842(+) GCACTA/CCAGCC 1 -- int10--------
    rs3143551,2
    C,A,H--100408859(-) tttccG/Atctgt 1 -- int111Minor allele frequency- A:0.01NA WA CSA EA 256
    rs3143561,2
    C,F,A,H--100408890(-) tattaA/Ggcttt 1 -- int111Minor allele frequency- G:0.33NS EA NA WA CSA 368
    rs58861411,2
    C--100408900(+) AAAAA-/AGTCAG 1 -- int1 trp30--------
    rs561358241,2
    C,F--100409021(+) AAATGA/TTTTGT 1 -- int13Minor allele frequency- T:0.09WA NA EA 358
    rs1413030001,2
    --100409044(+) AAAGCC/TTGTCT 1 -- int10--------
    rs1507985961,2
    --100409116(+) ATCCAA/GTTTGC 1 -- int10--------
    rs1901923001,2
    --100409167(+) GGTGCA/GTAGAA 1 -- int10--------
    rs1392247111,2
    --100409249(+) TGCTGC/TGGGAG 1 -- int10--------
    rs24371021,2
    C,F--100409311(+) CCTATC/AGAGAT 1 -- int16Minor allele frequency- A:0.28NA WA EA 364
    rs602918801,2
    C--100409532(+) CTCACG/ATCTGT 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1472018081,2
    --100409751(+) ATCTTA/GCCATT 1 -- int10--------
    rs1824159041,2
    --100409752(+) TCTTGC/TCATTG 1 -- int10--------
    rs1873724631,2
    C--100409802(+) AAAAAA/CAAAAT 1 -- int10--------
    rs2005950021,2
    --100409824(+) AAATT-/AAAAAA 1 -- int10--------
    rs1922867111,2
    --100410003(+) GGTCAC/GGAGTT 1 -- int10--------
    rs3143571,2
    C,F,A--100410069(-) catgcT/Cgacta 1 -- int18Minor allele frequency- C:0.49NA WA CSA 250
    rs1407952191,2
    C--100410165(+) GAGATC/TGCGCC 1 -- int10--------
    rs2005351871,2
    --100410344(+) GTGGCC/TGCAGA 1 -- int10--------
    rs556924401,2,,4
    C--100410454(+) CCAGGC/TGGATG 2 H R mis10--------
    rs1999976631,2
    --100410529(+) CCGTGA/TAGCCA 2 Y F mis10--------
    rs1833834291,2
    C--100410531(+) GTGTAA/GCCACC 2 G syn10--------
    rs22305851,2
    C,F,A,H--100410597(-) GTGTGC/TCGGGG 2 C syn124Minor allele frequency- T:0.31MN EA NS NA WA EU 9995
    rs1447442181,2
    C--100410653(+) TCCCGC/TTCCAG 1 -- int10--------
    rs616516801,2
    C,F--100410656(+) CGCTCC/TAGTGT 1 -- int11Minor allele frequency- T:0.11WA 118
    rs3143581,2
    C,F,A,H--100410657(-) CACACC/TGGAGC 1 -- int130Minor allele frequency- T:0.41EA NA NS CSA WA EU 5771
    rs1456923941,2
    C--100410666(+) TGGCCC/TTGCCC 1 -- int10--------
    rs2016306451,2
    C--100410683(+) GCTTCG/TTTCCC 1 -- int10--------
    rs2010756401,2
    C--100410708(+) CCTTCA/GGCTCT 1 -- int10--------
    rs1891907891,2
    C--100410852(+) GGCCCC/TGTCAG 1 -- int10--------
    rs731707961,2
    --100410905(+) CTTTTA/GGCCCC 1 -- int10--------
    rs132405251,2
    F--100410995(+) cgcagC/Tggcgc 1 -- int12Minor allele frequency- T:0.50NA 4
    rs1930545981,2
    --100411073(+) GCTGGG/TATTAC 1 -- int10--------
    rs1485110591,2
    C--100411206(+) GTGCTG/TGGATT 1 -- int10--------
    rs1845541061,2
    --100411215(+) TTATAA/GATAGG 1 -- int10--------
    rs2001541851,2
    --100411231(+) CCACAA/CCCGGC 1 -- int10--------
    rs2017557061,2
    C--100411233(+) ACACCC/TGGCCC 1 -- int10--------
    rs1866518871,2
    C--100411234(+) CACCCA/GGCCCC 1 -- int10--------
    rs2012292751,2
    --100411255(+) TCCCAA/TCAAAT 1 -- int10--------
    rs780813601,2
    C--100411277(+) ACCATA/GTCCGA 2 H Y mis10--------
    rs3143591,2
    C,F,A,H--100411278(-) ATCGGG/ACATGG 2 /G syn1 ese331Minor allele frequency- A:0.44MN NA NS EA WA CSA EU 8452
    rs1162405951,2
    C,F--100411287(+) ATGAGA/GTACTG 2 Y syn11Minor allele frequency- G:0.01NA 4552
    rs360502471,2,,4
    C--100411302(+) TGTTTG/CTCCGA 2 /D /E mis12Minor allele frequency- C:0.00NA EU 1325
    rs2020355301,2
    C--100411344(+) CTGTAG/TCCGAT 1 -- int11Minor allele frequency- T:0.00EU 1321
    rs743408621,2
    C--100411372(+) TAAACT/CGAGTC 1 -- int12Minor allele frequency- C:0.10CSA WA 121
    rs1414594411,2
    C--100411398(+) GCACAA/CACACC 1 -- int10--------
    rs1997075281,2
    --100411551(+) GCAGAC/GAACTG 2 L V mis10--------
    rs2012520941,2
    --100411600(+) ACTGCC/TGTGCC 2 T syn10--------
    rs1395947391,2
    C,F--100411628(+) GCTCCC/TGCCAG 2 Q R mis11Minor allele frequency- T:0.00NA 4444
    rs556821611,2
    C,F--100411639(+) CCCTCG/ACTCTC 2 /S syn12Minor allele frequency- A:0.00NA 4578
    rs284444971,2
    C,F--100411688(+) TCCTGT/CAGGAG 1 -- int11Minor allele frequency- C:0.10WA 118
    rs38901441,2
    C,F,H--100411875(+) GTTTCG/AAAATC 1 -- int121Minor allele frequency- A:0.23NS EA NA WA CSA 2253
    rs3143601,2
    C,F,A--100411918(-) gtctcA/Caaaaa 1 -- int17Minor allele frequency- C:0.33NA CSA WA 248
    rs1450963191,2
    --100412144(+) CAGCCA/GCCAGA 1 -- int10--------
    rs777035011,2
    C--100412214(+) GAAACA/GTTCTA 1 -- int10--------
    rs1918055621,2
    --100412372(+) TGGCTC/TATGCC 1 -- int10--------
    rs38470611,2
    C,F,A,H--100412374(-) caggcA/Gtgagc 1 -- int17Minor allele frequency- G:0.31NA WA CSA EA 248
    rs568020681,2
    C,F--100412529(+) AGATAG/CTCAGG 1 -- int12Minor allele frequency- C:0.33WA CSA 3
    rs1446824421,2
    --100412992(+) ATATAC/TACTAC 1 -- int10--------
    rs3143611,2
    C,F,H--100413005(-) gtttaT/Cgtatg 1 -- int120Minor allele frequency- C:0.24NS EA NA CSA WA 2252
    rs1839922471,2
    --100413245(+) TTGAAC/TAGGCA 1 -- int10--------
    rs731707981,2
    C,F--100413380(+) GATGCG/CGGAGG 1 -- int11Minor allele frequency- C:0.08NA 120
    rs126707731,2
    C,H--100413426(+) caacaT/Caggga 1 -- int13Minor allele frequency- C:0.34WA EA 240
    rs1383556041,2
    --100413444(+) TCAACA/GAAACA 1 -- int10--------
    rs1492441231,2
    --100413572(+) GCCACC/TGCACT 1 -- int10--------
    rs1434673441,2
    C--100413632(+) TAGGCC/TGGGCG 1 -- int10--------
    rs1886768261,2
    --100413637(+) CGGGCG/TTGGTG 1 -- int10--------
    rs3143621,2
    C,H--100413774(-) gtctcG/Actctg 1 -- int18Minor allele frequency- A:0.01NA WA CSA EA 133
    rs1480563191,2
    --100413849(+) CCTGTC/TACCTC 1 -- int10--------
    rs1821598121,2
    --100413900(+) TTTTGC/TTGGAT 1 -- int10--------
    rs1851104481,2
    C--100413912(+) GGGAAC/TGGGGA 1 -- int10--------
    rs764430521,2
    C--100413954(+) GCCTGC/TGGTGA 1 -- int13Minor allele frequency- T:0.16WA EA 240
    rs1437611481,2
    C--100413992(+) GCTCTA/GTTGCC 1 -- int10--------
    rs1907533241,2
    --100414100(+) ACAGGC/TGTGCA 1 -- int10--------
    rs1168242621,2
    --100414146(+) AGACGC/TGGTTT 1 -- int10--------
    rs1169795621,2
    F--100414147(+) GACGCG/AGTTTC 1 -- int11Minor allele frequency- A:0.02NA 120
    rs1819863511,2
    --100414155(+) TTCACC/TATGCT 1 -- int10--------
    rs1851406681,2
    --100414176(+) GTCTCC/GAACTC 1 -- int10--------
    rs1471855681,2
    --100414193(+) TCAAGC/TGATCC 1 -- int10--------
    rs3143631,2
    C,F,A,H--100414386(-) ATCACA/GTGGCA 1 -- int117Minor allele frequency- G:0.08NS EA NA WA 1884
    rs734131591,2
    C--100414427(+) TTGACC/TGGGTG 1 -- int13Minor allele frequency- T:0.35WA EA 240
    rs1895308291,2
    --100414453(+) GTAATC/TCCAGC 1 -- int10--------
    rs1405235541,2
    --100414499(+) AGGAGA/TTCGAG 1 -- int10--------
    rs1808253711,2
    --100414557(+) AAAATC/TGGCCA 1 -- int10--------
    rs1856255751,2
    --100414559(+) AATCGG/TCCAGG 1 -- int10--------
    rs1911122621,2
    --100414628(+) TGAATA/CCGGGA 1 -- int10--------
    rs1837711581,2
    --100414636(+) GGAGGC/TGGAGG 1 -- int10--------
    rs353047291,2
    C--100414726(+) AAAAAA/-GATGA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1177727361,2
    C,F--100414748(+) AGACCT/GGGGGT 1 -- int12Minor allele frequency- G:0.06NA EU 233
    rs1430692691,2
    --100414758(+) TCTTCC/TCAGGA 1 -- int10--------
    rs1166728511,2
    C,F--100414787(+) ACCCCC/TACCCT 1 -- int11Minor allele frequency- T:0.09WA 118
    rs2014519331,2
    C--100414806(+) TCCCCA/GGGCTC 1 -- int11Minor allele frequency- G:0.00EU 663
    rs2006914351,2
    C--100414918(+) GCCCCC/TGCAGC 2 Q R mis10--------
    rs1477371641,2
    C,F--100414928(+) CTCTGC/TCCGGT 2 T A mis11Minor allele frequency- T:0.00NA 3100
    rs1508526111,2
    C--100414994(+) AGAGGC/TAGTGG 1 -- int10--------
    rs2001808291,2
    C--100415013(+) TCACCC/TGGGAA 1 -- int10--------
    rs1882574461,2
    --100415111(+) GAACTC/TACGCA 1 -- int10--------
    rs1393324301,2
    --100415141(+) TCATAA/GTATCA 1 -- int10--------
    rs744918531,2
    F--100415152(+) TTCCTT/ATTTTT 1 -- int11Minor allele frequency- A:0.04NA 120
    rs1499817181,2
    --100415155(+) CTTTTC/TTTTAA 1 -- int10--------
    rs1139241611,2
    C,F--100415371(+) GGTCTC/TGAACT 1 -- int12Minor allele frequency- T:0.50WA CSA 4
    rs1923471571,2
    --100415429(+) TTACAA/GGCATG 1 -- int10--------
    rs1133241251,2
    C,F--100415436(+) CATGAG/ACCACT 1 -- int12Minor allele frequency- A:0.50WA CSA 4
    rs1123180311,2
    C,F--100415544(+) ACTGCG/AGTGGC 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1832314261,2
    C--100415643(+) GCCACC/TGCGCC 1 -- int10--------
    rs1868131751,2
    --100415689(+) TTCACC/TGTGTT 1 -- int10--------
    rs1916148361,2
    --100415732(+) GATCCA/GCCCAC 1 -- int10--------
    rs1406652221,2
    C--100415812(+) GAGATG/TAAGTT 1 -- int10--------
    rs1437892981,2
    --100415929(+) TCAGCC/GACTGT 1 -- int10--------
    rs790210611,2
    F--100415959(+) TTACAG/ATAACT 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1511667521,2
    --100416011(+) GCTTAC/TCCAAG 1 -- int10--------
    rs24061451,2
    H--100416044(-) aattcC/Gagctc 1 -- int14Minor allele frequency- G:0.00NS EA 420
    rs731708001,2
    C,F--100416052(+) ATTCAA/GATGCC 1 -- int13Minor allele frequency- G:0.08WA NA EA 358
    rs1402307341,2
    --100416066(+) CAGGTA/GCCTGC 1 -- int10--------
    rs1144378301,2
    F--100416073(+) CTGCAA/GCCCAG 1 -- int11Minor allele frequency- G:0.02WA 118
    rs38578091,2
    C,F,A--100416139(-) AAGGTA/GAGGCC 1 -- int16Minor allele frequency- G:0.08WA CSA EA EU 1429
    rs38914951,2
    H--100416153(+) ATGGTA/CTTTGA 2 D Y mis14Minor allele frequency- C:0.00NS EA 404
    rs1466748441,2
    C,F--100416180(+) AGCCCC/TACTGG 2 R G mis12Minor allele frequency- T:0.00NA EU 5765
    rs1415449671,2
    C--100416192(+) TGCCCG/AGGGAA 2 /R /W mis11Minor allele frequency- A:0.00NA 4536
    rs1504253691,2
    F--100416206(+) CCCAGG/ACCAGG 2 /A /V mis11Minor allele frequency- A:0.00NA 4524
    rs1382347521,2
    F--100416207(+) CCAGGC/TCAGGC 2 T A mis11Minor allele frequency- T:0.00NA 4526
    rs1502915241,2
    C--100416208(+) CAGGCC/GAGGCT 2 L syn10--------
    rs1460647801,2
    C--100416233(+) AGGACC/AGCGTC 2 /R /L mis11Minor allele frequency- A:0.00NA 4514
    rs1837594301,2
    C--100416236(+) ACCGCA/GTCACC 2 T M mis10--------
    rs1441731,2
    C,F,A,H--100416250(-) GTGTCC/TGACAT 2 S syn129Minor allele frequency- T:0.45NS EA NA CSA WA EU 8379
    rs2009801821,2
    --100416296(+) ACCCTG/TGTGCA 1 -- int10--------
    rs3720446781,2
    C--100416305(+) CATGGC/TAGCTC 1 -- int10--------
    rs2017234491,2
    --100416323(+) AACTT-/AAAAAA 1 -- int10--------
    rs3143641,2
    C,F,A--100416332(-) AAAAAA/TTTTTT 1 -- int1 trp36Minor allele frequency- T:0.20NA WA EA 364
    rs3143651,2
    C,F,A--100416354(-) GAGCAC/GGACTC 1 -- int17Minor allele frequency- G:0.23NA WA EA 366
    rs3143661,2
    C,F,A--100416509(-) GAAACC/TCCATG 1 -- int16Minor allele frequency- T:0.08NA EA 130
    rs38470621,2
    C,A--100416519(-) CCAACA/GTGGTG 1 -- int10--------
    rs1422393691,2
    --100416722(+) CCTCAC/TCCTCT 1 -- int10--------
    rs1461845861,2
    --100416724(+) TCACCC/TTCTCT 1 -- int10--------
    rs1387815121,2
    --100416820(+) GCCTCC/TGACTC 1 -- int10--------
    rs1428048821,2
    C--100416870(+) GCTGGA/GACCAC 1 -- int10--------
    rs125372121,2
    C,H--100416932(+) TTCCTA/GTGTTA 1 -- int14Minor allele frequency- G:0.33WA CSA EA 241
    rs1873097681,2
    --100416975(+) GATCCA/GCCTGT 1 -- int10--------
    rs3143671,2
    C,H--100417011(-) ctcacT/Gcctgt 1 -- int18Minor allele frequency- G:0.00NA WA CSA 16
    rs1170005451,2
    F--100417041(+) CCCTCT/CTTCTG 1 -- int11Minor allele frequency- C:0.01EA 120
    rs1481070021,2
    C--100417157(+) CCAGCC/TGCCCC 1 -- int10--------
    rs747798011,2
    C--100417184(+) CCTCTC/GGGTCA 2 P R mis10--------
    rs617359751,2
    C,F--100417218(+) TGGGAC/TGGGCC 2 I V mis12Minor allele frequency- T:0.00NS NA 4628
    rs2022206241,2
    C--100417225(+) GGCCCC/TGTGGC 2 T syn10--------
    rs1149268391,2
    C,F--100417332(+) GGGGCC/TGGGGT 2 S G mis12Minor allele frequency- T:0.00WA NA 4210
    rs22890581,2
    C,F--100417333(+) GGGCCG/AGGGTC 2 /P syn1 ese31Minor allele frequency- A:0.02EA 1494
    rs557209811,2,,4
    C--100417364(+) AGGGCG/ACACAG 2 /A /V mis11Minor allele frequency- A:0.00NA 2744
    rs2020060981,2
    C--100417397(+) GGCAGC/TGGAGG 2 H R mis10--------
    rs2014676891,2
    --100417398(+) GCAGCA/GGAGGG 2 R C mis10--------
    rs1926400171,2
    C--100417409(+) CGTAGC/GTGAGG 2 T S mis10--------
    rs773038481,2