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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EPHB4 Gene

protein-coding   GIFtS: 69
GCID: GC07M100402

EPH receptor B4

(Previous name: EphB4 )
(Previous symbol: HTK)
 Explore 47 diseases affiliated with
EPHB4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for EPHB4    

Aliases
for EPHB4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
EPH Receptor B41 2     Tyro111
HTK1 2 3 5     Ephrin Receptor EphB42
MYK12 3 5     Ephrin Type-B Receptor 42
Hepatoma Transmembrane Kinase2 3     Soluble EPHB4 Variant 12
Tyrosine-Protein Kinase TYRO112 3     Soluble EPHB4 Variant 22
TYRO112 3     Soluble EPHB4 Variant 32
EC 2.7.10.13 8     Tyrosine-Protein Kinase Receptor HTK2
EphB41     EC 2.7.108

External Ids:    HGNC: 33951   Entrez Gene: 20502   Ensembl: ENSG000001964117   OMIM: 6000115   UniProtKB: P547603   

Export aliases for EPHB4 gene to outside databases

Previous GC identifers: GC07M098934 GC07M099997 GC07M100011 GC07M100044 GC07M100238 GC07M095030


Summaries
for EPHB4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for EPHB4:
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous
system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class,
which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are
transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their
extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make
up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to
ephrin-B2 and plays an essential role in vascular development. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: EPHB4_HUMAN, P54760
Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent
cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream
of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is
referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in
heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward
signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal
blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis

summary for EPHB4:
Ephrins are a family of receptor tyrosine kinases (RTKs) that influence cell migration. In conjunction with
the ephrin ligands, ephrin receptors are involved in a variety of developmental events. EphB4 is
overexpressed in many tumor types, including breast and prostate cancer.

Gene Wiki entry for EPHB4 (EPH receptor B4)


Genomic Views
for EPHB4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EPHB4 gene promoter:
         AP-2rep   AREB6   p53   AP-1   p300   Lmo2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EPHB4 promoter sequence
   Search SABiosciences Chromatin IP Primers for EPHB4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPHB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22

EPHB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHB4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M100402:  view genomic region     (about GC identifiers)

Start:
 100,400,187 bp from pter      End:
 100,425,143 bp from pter
Size:
 24,957 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 99,759,792-99,784,748     

Proteins
for EPHB4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: EPHB4_HUMAN, P54760 (See protein sequence)
Recommended Name: Ephrin type-B receptor 4 precursor  
Size: 987 amino acids; 108270 Da
Subunit: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor
dimer. Oligomerization is probably required to induce biological responses (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein
Developmental stage: Expressed in fetal heart, lung, liver and to a lower extent in brain. Not expressed in adult brain
6/15 PDB 3D structures from and Proteopedia for EPHB4 (see all 15):
2BBA (3D)        2E7H (3D)        2HLE (3D)        2QKQ (3D)        2VWU (3D)        2VWV (3D)    
Secondary accessions: Q9BTA5 Q9BXP0

Explore the universe of human proteins at neXtProt for EPHB4: NX_P54760

Post-translational modifications:

  • Phosphorylated; autophosphorylation is stimulated by EFNB21
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P54760

    • 4/25 DME Specific Peptides for EPHB4 (P54760) (see all 25)
     MSNQDVI  RDLAARN  SDPTYTS  QLMLDCW 

    EPHB4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004435.3  
    ENSEMBL proteins: 
     ENSP00000353833   ENSP00000350896  

    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant EPHB4 Protein
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    OriGene Purified Protein: EPHB4
    OriGene Protein Over-expression Lysate: EPHB4
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    Novus Biologicals EPHB4 Proteins
    Novus Biologicals EPHB4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for EPHB4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane IDA8188704
    GO:0009986cell surface IDA12493773


    EPHB4 for ontologies           About GeneDecksing



    EPHB4 Antibody Products: 
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    Uscn ELISAs and CLIAs for EPHB4

    Protein Domains /
    Families
    for EPHB4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    EPHB4 for domains           About GeneDecksing

    5/16 InterPro domains/families (see all 16):
     IPR017441 Protein_kinase_ATP_BS
     IPR003961 Fibronectin_type3
     IPR021129 SAM_type1
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P54760

    ProtoNet protein and cluster: P54760

    5 Blocks protein families:
    IPB001090 Ephrin receptor
    IPB001426 Receptor tyrosine kinase
    IPB001660 Sterile alpha motif SAM
    IPB003962 Fibronectin type III repeat signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EPHB4_HUMAN, P54760
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Function
    for EPHB4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: EPHB4_HUMAN, P54760
    Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent
    cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream
    of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is
    referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in
    heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward
    signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal
    blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for EPHB4:
    EPH-related tyrosine kinase receptor,binding ephrin B4,expressed in projecting neurons and their target fields,involved
    in short-range contact-mediated axonal guidance,also involved in angiogenesis by marking venous but not arterial
    endothelial cells

    Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EPHB4
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate EPHB4 (see all 39):
    hsa-miR-300 hsa-miR-106a hsa-miR-3653 hsa-miR-624 hsa-miR-301a hsa-miR-519a hsa-miR-124 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmid: EPHB4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EPHB4 (see all 4)
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPHB4

    Gene Editing
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    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: EPHB4 (NM_004444)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHB4 

    Cell Line
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    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHB4

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004714transmembrane receptor protein tyrosine kinase activity IDA8188704
    GO:0005003ephrin receptor activity IDA12734395
    GO:0005515protein binding IPI16867992
    GO:0005524ATP binding IEA--


    EPHB4 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for EPHB4:
     Decreased focal adhesion (FA)   Increased cell death in HCT116  Increased colony dispersion (i 

    Animal Models:
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ephb4):
     cardiovascular system  embryogenesis  growth/size  mortality/aging  muscle 

    EPHB4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for EPHB4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    		P2Y Receptor Signaling0.38
    2Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    3Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		14-3-3 Induced Intracellular Signaling0.59
    		GSK3 Signaling0.61
    		eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    		Actin Nucleation by ARP-WASP Complex1.00
    		CDC42 Pathway0.34
    		Actin Nucleation and Branching0.66
    5Cell adhesion_Ephrins signaling
    		Cell adhesion_Ephrins signaling1.00
    		EPHB forward signaling0.30
    		Cell adhesion Ephrins signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for EPHB4
        Cytoskeleton remodeling Reverse signaling by ephrin B
    Cell adhesion Ephrins signaling

    31 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EPHB4 (see first 5)
        MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Ephrin-Eph Signaling
    Intracellular Calcium Signaling
    JNK Pathway
    mTOR Pathway
    P2Y Receptor Signaling
    eNOS Signaling
    GSK3 Signaling
    Actin Nucleation and Branching
    Rho Family GTPases
    Akt Signaling
    Pancreatic Adenocarcinoma
    Activation of PKA through GPCR
    JAK-STAT Pathway
    Estrogen Pathway
    CDC42 Pathway
    Actin Nucleation by ARP-WASP Complex
    EphB-EphrinB Signaling
    Breast Cancer Regulation by Stathmin1
    ERK Signaling
    ILK Signaling
    GPCR Pathway
    p38 Signaling
    14-3-3 Induced Intracellular Signaling
    Activation of cAMP-Dependent PKA
    Nanog in Mammalian ESC Pluripotency
    NFAT in Immune Response
    Ras Pathway

    2 GeneGo (Thomson Reuters) Pathways for EPHB4
        Cytoskeleton remodeling Reverse signaling by ephrin B
    Cell adhesion Ephrins signaling

    3 BioSystems Pathways for EPHB4 
        Ephrin B reverse signaling
    EPHB forward signaling
    EphrinB-EPHB pathway


    1         Kegg Pathway  (Kegg details for EPHB4):
        Axon guidance


    EPHB4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EPHB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/15 Interacting proteins for EPHB4 (P547603 ENSP000003508964) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRIN1Q055863, ENSP000003606164I2D: score=2 STRING: ENSP00000360616
    SDC3O750563, ENSP000003444684I2D: score=2 STRING: ENSP00000344468
    EFNB2P527993, ENSP000002453234I2D: score=1 STRING: ENSP00000245323
    JUNP054123, ENSP000003602664I2D: score=1 STRING: ENSP00000360266
    EGFRP005333, ENSP000002754934I2D: score=1 STRING: ENSP00000275493
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis ISS--
    GO:0002042cell migration involved in sprouting angiogenesis IDA12734395
    GO:0003007heart morphogenesis ISS--
    GO:0007155cell adhesion IDA12734395
    GO:0046777protein autophosphorylation IDA8188704


    EPHB4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for EPHB4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EPHB4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for EPHB4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    NVP BHG 712Potent EphB4 kinase inhibitor[940310-85-0]

    2 HMDB Compounds for EPHB4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    8 DrugBank Compounds for EPHB4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3-({4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZAMIDE-- --target--10592235
    3-({4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzenesulfonamide-- --target--10592235
    N'-(3-CHLORO-4-METHOXY-PHENYL)-N-(3,4,5-TRIMETHOXYPHENYL)-1,3,5-TRIAZINE-2,4-DIAMINE-- --target--10592235
    N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3,4,5- TRIMETHOXYPHENYL)PYRIMIDINE-2,4-DIAMINE-- --target--10592235
    N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3-MORPHOLIN-4-YLPHENYL)PYRIMIDINE-2,4-DIAMINE-- --target--10592235
    N'-(5-chloro-1,3-benzodioxol-4-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine-- --target--10592235
    N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine-- --target--10592235
    N-[3-[[4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL]AMINO]PHENYL]METHANESULFONAMIDE-- --target--10592235

    3 Novoseek chemical compound relationships for EPHB4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 66 35 8188704 (4), 10221518 (3), 15358160 (2), 16816380 (2) (see all 16)
    vegf 40.8 10 20338920 (3), 19950560 (1), 19923070 (1), 15471957 (1) (see all 6)
    thymidine 38.9 9 7593001 (2), 7969135 (1), 10502302 (1), 10639574 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about EPHB4 

    Transcripts
    for EPHB4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for EPHB4 gene: 
    NM_004444.4  

    Unigene Cluster for EPHB4:

    EPH receptor B4
    Hs.437008  [show with all ESTs]
    Unigene Representative Sequence: AB209644
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360620 ENST00000358173(uc003uwn.1 uc010lhj.1 uc011kkf.1 uc011kkg.1 uc011kkh.1)
    ENST00000487222(uc003uwm.1) ENST00000492403 ENST00000478459 ENST00000467515
    ENST00000477446 ENST00000489808 ENST00000492878

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EPHB4
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate EPHB4 (see all 39):
    hsa-miR-300 hsa-miR-106a hsa-miR-3653 hsa-miR-624 hsa-miR-301a hsa-miR-519a hsa-miR-124 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmid: EPHB4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EPHB4 (see all 4)
    OriGene shRNA RFP: EPHB4
    OriGene siRNA: EPHB4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPHB4
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPHB4

    Additional cDNA sequence: 

    AB209644.1 AK301224.1 AY056048.1 BC004264.1 BC052804.1 EU826608.1 EU826609.1 EU826610.1 
    U07695.1 

    12 DOTS entries:

    DT.100689231  DT.100818782  DT.444136  DT.121068866  DT.100818780  DT.121068891  DT.95282899  DT.121068837 
    DT.97845932  DT.91914735  DT.95081702  DT.95282873 

    24/188 AceView cDNA sequences (see all 188):

    BM771479 BU683397 AW024723 BM857398 AW589657 AV708776 BM766176 AI368193 
    BM823021 AI273230 AI281014 AI270622 AA659141 BM757081 AW449338 CK820751 
    BM856991 CR621822 BQ670731 BE466828 CA487258 BM742052 BC004264 BM830054 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for EPHB4 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17
    SP1:              -                                               -                 -                                                               
    SP2:              -                                               -                 -                                                     -         
    SP3:                                                              -                 -                                                               
    SP4:                                                                                -                                                               
    SP5:                                                                                                  -                                             


    ECgene alternative splicing isoforms for EPHB4

    Expression
    for EPHB4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EPHB4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTGTTTCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    EPHB4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartCardinal VeinsVenous Endothelial CellsEndothelium
    LungPulmonary Capillary PlexusVenous Endothelial CellsEndothelium
    Lateral Plate MesodermEmbryonic Capillary PlexusAngioblastsEndothelium
    LungPulmonary Capillary PlexusAngioblastsEndothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    Endothelial-like cells (Generation of hemato...)
    Endothelial-like cells (Derivation and purif...)

    See EPHB4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EPHB4

    SOURCE GeneReport for Unigene cluster: Hs.437008

    UniProtKB/Swiss-Prot: EPHB4_HUMAN, P54760
    Tissue specificity: Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal
    muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in cell
    lines derived from liver, breast, colon, lung, melanocyte and cervix

        SABiosciences Expression via Pathway-Focused PCR Array including EPHB4: 
              Angiogenesis in human mouse rat

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    Orthologs
    for EPHB4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for EPHB4 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia EPHA66
    		 --
    		 58(a)
    		 1 ↔ 1
    		 GL344569.1(5445-27408)
    African clawed frog
    (Xenopus laevis)    		 Amphibia ephB4a2 eph receptor tyrosine kinase 75.82(n)    AJ236867.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii AJ005026.22   -- 78.6(n)   30688  AJ005026.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Eph3 protein amino acid phosphorylation
    transmembrane more    		 38(a)
    (best of 2)    		   102C2   --
    worm
    (Caenorhabditis elegans)    		 Secernentea vab-16
    kin-246
    (see all 6)    		 protein KINase family member (kin-24)
    (see all 6)    		 28(a)
    17(a)
    (see all 6)    		 possible ortholog
    possible ortholog
    (see all 6)    		 II(4571997-4591357)
    IV(9839089-9841052)


    ENSEMBL Gene Tree for EPHB4 (if available)
    TreeFam Gene Tree for EPHB4 (if available) 

    Paralogs
    for EPHB4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EPHB4 gene
    EPHB12  EPHA22  EPHB32  EPHA42  EPHA52  EPHB62  EPHA62  EPHB22  
    EPHA12  EPHA82  EPHA32  EPHA72  EPHA102  
    18/23 SIMAP similar genes for EPHB4 using alignment to 7 protein entries:     EPHB4_HUMAN (see all proteins) (see all similar genes):
    EPHB3    EPHB1    EPHB2 variant protein    EPHA2    EPHA3    EPHA4
    EPHA7    EPHB2    EPHA6    EPHA8    FRK    EPHA5
    HCK    YES1    EPHA10    EPHB6    LCK    LYN

    EPHB4 for paralogs           About GeneDecksing



    Genomic Variants
    for EPHB4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/553 NCBI SNPs in EPHB4 are shown (see all 553)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1149419421,2
    		C,--100399695(+) CACACA/GTGGGG 1 -- ds50010--------
    rs746262601,2
    		C,F,--100399697(+) CACGTG/TGGGGG 1 -- ds50011Minor allele frequency- T:0.10WA 118
    rs117732811,2
    		H--100399704(+) GGGGGG/TCCCTT 1 -- ds50010--------
    rs559822651,2
    		C,F,--100399802(+) TCCATC/TCACGG 1 -- ds50013Minor allele frequency- T:0.08WA NA EA 358
    rs1489635661,2
    		--100399805(+) ATCCAC/TGGAAC 1 -- ds50010--------
    rs1909626041,2
    		--100400105(+) TCCAGA/CCCTCT 1 -- ds50010--------
    rs559455031,2
    		C,--100400124(+) TCGGTC/AAGCCA 1 -- ds50015Minor allele frequency- A:0.14WA CSA NA EA 362
    rs1823823421,2
    		--100400277(+) ACCGGC/TGTCCG 1 -- ut310--------
    rs1877509731,2
    		--100400294(+) GGTTCC/TACCAC 1 -- ut310--------
    rs1436431191,2
    		--100400297(+) TCCACC/TACCAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for EPHB4 (100400187 - 100425143 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for EPHB4
         1 CNV: 3692

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    Disorders / Diseases
    for EPHB4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    EPHB4 for disorders           About GeneDecksing

    OMIM gene information: 600011    OMIM disorders: --

    20/47 diseases for EPHB4 (see all 47):    About MalaCards
    prostate cancer    conjunctivitis    proliferative diabetic retinopathy    prostatitis
    diabetic retinopathy    arteriovenous malformation    venous malformations    leukemia/lymphoma
    squamous cell carcinoma of the head and neck    leukemia/lymphoma, t-cell    squamous cell carcinoma    acute lymphoblastic leukemia
    lymphoblastic leukemia    kaposi's sarcoma    endometrial carcinoma    carcinoma
    endometrial cancer    glomerulopathy    colon carcinoma    hepatocellular carcinoma

    1 disease from the University of Copenhagen DISEASES database for EPHB4:
    Cancer

    10/22 Novoseek disease relationships for EPHB4 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinal neovascularization 61.7 1 15914639 (1)
    neovascularization 52.9 2 17133777 (1), 17510705 (1)
    hnscc 47 24 16615113 (4), 17043250 (4), 18794445 (4), 14661437 (2)
    cancer 32.9 14 19552627 (3), 17108150 (1), 19879134 (1), 17241664 (1) (see all 9)
    proliferative diabetic retinopathy 31.3 1 17133777 (1)
    tumors 29.5 59 16816380 (4), 19366806 (4), 16615113 (3), 20133814 (3) (see all 26)
    endometrial carcinoma 25.2 4 11295082 (2), 12562648 (1)
    carcinoma squamous cell 24.1 8 16615113 (2), 17043250 (2), 18794445 (2), 17611172 (1) (see all 5)
    retinopathy 21.2 5 15914639 (2), 15289137 (1), 20503366 (1), 19232363 (1)
    ovarian cancer 20 10 18231102 (4), 17353927 (2), 18281782 (2)

    Human Genome Epidemiology (HuGE) Navigator: EPHB4 (1 document)

    Export disorders for EPHB4 gene to outside databases

    Publications
    for EPHB4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EPHB4 gene, integrated from 9 sources (see all 163):
    (articles sorted by number of sources associating them with EPHB4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily. (PubMed id 8188704)1, 2, 3, 9 Bennett B.D.... Scadden D.T. (1994)
    2. Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells. (PubMed id 12734395)1, 2, 9 Fuller T....Augustin H.G. (2003)
    3. Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity. (PubMed id 16867992)1, 2, 9 Chrencik J.E....Kuhn P. (2006)
    4. EphB4 controls blood vascular morphogenesis during postnatal angiogenesis. (PubMed id 16424904)1, 2, 9 Erber R....Vajkoczy P. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. (PubMed id 11239002)1, 2 Wilson M.D....Koop B.F. (2001)
    7. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PubMed id 9267020)1, 2 (1997)
    8. Receptor tyrosine kinase, EphB4 (HTK), accelerates differentiation of select human hematopoietic cells. (PubMed id 11929761)1, 9 Wang Z....Scadden D.T. (2002)
    9. EphB4 expression and biological significance in prostate cancer. (PubMed id 15930280)1, 9 Xia G....Gill P.S. (2005)
    10. The receptor tyrosine kinase EphB4 is overexpressed in ovarian cancer, provides survival signals and predicts poor outcome. (PubMed id 17353927)1, 9 Kumar S.R....Gill P.S. (2007)

    External Searches for EPHB4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing EPHB4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2050 HGNC: 3395 AceView: EPHB4 Ensembl:ENSG00000196411 euGenes: HUgn2050
    ECgene: EPHB4 Kegg: 2050 H-InvDB: EPHB4

    Other Databases showing EPHB4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing EPHB4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EPHB4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EPHB4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for EPHB4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for EPHB4 gene:
    Search GeneIP for patents involving EPHB4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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