Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



EPHB4 Gene

protein-coding   GIFtS: 73
GCID: GC07M100402

EPH Receptor B4

(Previous name: EphB4)
(Previous symbol: HTK)
  See EPHB4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
EPH Receptor B41 2     Ephrin Receptor EphB42
HTK1 2 3 5     Ephrin Type-B Receptor 42
MYK12 3 5     Soluble EPHB4 Variant 12
Hepatoma Transmembrane Kinase2 3     Soluble EPHB4 Variant 22
Tyrosine-Protein Kinase TYRO112 3     Soluble EPHB4 Variant 32
TYRO112 3     Tyrosine-Protein Kinase Receptor HTK2
EC 2.7.10.13 8     EC 2.7.108
EphB41     

External Ids:    HGNC: 33951   Entrez Gene: 20502   Ensembl: ENSG000001964117   OMIM: 6000115   UniProtKB: P547603   

Export aliases for EPHB4 gene to outside databases

Previous GC identifers: GC07M098934 GC07M099997 GC07M100011 GC07M100044 GC07M100238 GC07M095030


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for EPHB4 Gene:
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the
nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A
(EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B
(EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on
the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B
ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein
encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. (provided by RefSeq,
Jul 2008)

GeneCards Summary for EPHB4 Gene:
EPHB4 (EPH receptor B4) is a protein-coding gene. Diseases associated with EPHB4 include prostate cancer. GO annotations related to this gene include ephrin receptor activity and transmembrane receptor protein tyrosine kinase activity. An important paralog of this gene is EPHB1.

UniProtKB/Swiss-Prot: EPHB4_HUMAN, P54760
Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on
adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2
plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell
migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing
cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus
important in the context of tumor angiogenesis

summary for EPHB4 Gene:
Ephrins are a family of receptor tyrosine kinases (RTKs) that influence cell migration. In conjunction with
the ephrin ligands, ephrin receptors are involved in a variety of developmental events. EphB4 is
overexpressed in many tumor types, including breast and prostate cancer.

Gene Wiki entry for EPHB4 (EPH receptor B4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the EPHB4 gene promoter:
         AP-2rep   AREB6   p53   AP-1   p300   Lmo2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEPHB4 promoter sequence
   Search Chromatin IP Primers for EPHB4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EPHB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22

EPHB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHB4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M100402:  view genomic region     (about GC identifiers)

Start:
100,400,187 bp from pter      End:
100,425,143 bp from pter
Size:
24,957 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 99,759,792-99,784,748     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: EPHB4_HUMAN, P54760 (See protein sequence)
Recommended Name: Ephrin type-B receptor 4 precursor  
Size: 987 amino acids; 108270 Da
Subunit: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a
receptor dimer. Oligomerization is probably required to induce biological responses (By similarity)
Developmental stage: Expressed in fetal heart, lung, liver and to a lower extent in brain. Not expressed in adult
brain
Selected PDB 3D structures from and Proteopedia for EPHB4 (see all 18):
2BBA (3D)        2E7H (3D)        2HLE (3D)        2QKQ (3D)        2VWU (3D)        2VWV (3D)    
Secondary accessions: Q9BTA5 Q9BXP0

Explore the universe of human proteins at neXtProt for EPHB4: NX_P54760

Explore proteomics data for EPHB4 at MOPED

Post-translational modifications: 

  • Phosphorylated; autophosphorylation is stimulated by EFNB21
  • Glycosylation2 at Asn203, Asn335, Asn426
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for EPHB4 (P54760) (see all 25)
     MSNQDVI  RDLAARN  SDPTYTS  QLMLDCW 


    See EPHB4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004435.3  
    ENSEMBL proteins: 
     ENSP00000353833   ENSP00000350896  

    EPHB4 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant EPHB4 Protein
    R&D Systems Recombinant & Natural Proteins for EPHB4
    Enzo Life Sciences proteins for EPHB4
    OriGene Purified Proteins for EPHB4
    OriGene Protein Over-expression Lysate for EPHB4
    OriGene MassSpec for EPHB4
    OriGene Custom Protein Services for EPHB4
    GenScript Custom Purified and Recombinant Proteins Services for EPHB4
    Novus Biologicals EPHB4 Proteins
    Novus Biologicals EPHB4 Lysate
    Browse Sino Biological Recombinant Proteins
    Sino Biological Cell Lysate for EPHB4
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EPHB4

     
    Search eBioscience for Proteins for EPHB4 

    EPHB4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of EPHB4
    R&D Systems Antibodies for EPHB4
    OriGene Antibodies for EPHB4
    OriGene Custom Antibody Services for EPHB4
    Novus Biologicals EPHB4 Antibodies
    Abcam antibodies for EPHB4
    Cloud-Clone Corp. Antibodies for EPHB4
    ThermoFisher Antibodies for EPHB4
    LSBio Antibodies in human, mouse, rat for EPHB4

    EPHB4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for EPHB4
    R&D Systems ELISAs for EPHB4         (see all)
    GenScript EPHB4-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EPHB4
    Cloud-Clone Corp. CLIAs for EPHB4
    Search eBioscience for ELISAs for EPHB4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    EPH: EPH receptors
    SAMD: Sterile alpha motif (SAM) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: EPH receptor B4
    Ephrin receptor family
    Ephrin receptor family

    Selected InterPro protein domains (see all 18):
     IPR017441 Protein_kinase_ATP_BS
     IPR003961 Fibronectin_type3
     IPR021129 SAM_type1
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P54760

    ProtoNet protein and cluster: P54760

    5 Blocks protein domains:
    IPB001090 Ephrin receptor
    IPB001426 Receptor tyrosine kinase
    IPB001660 Sterile alpha motif SAM
    IPB003962 Fibronectin type III repeat signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EPHB4_HUMAN, P54760
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Find genes that share domains with EPHB4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EPHB4_HUMAN, P54760
    Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on
    adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
    pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
    the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2
    plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell
    migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing
    cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus
    important in the context of tumor angiogenesis
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for EPHB4:
    EPH-related tyrosine kinase receptor,binding ephrin B4,expressed in projecting neurons and their target
    fields,involved in short-range contact-mediated axonal guidance,also involved in angiogenesis by marking venous
    but not arterial endothelial cells

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity IDA8188704
    GO:0005003ephrin receptor activity IDA12734395
    GO:0005515protein binding IPI16867992
         
    Find genes that share ontologies with EPHB4           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for EPHB4:
     Decreased focal adhesion (FA)   Increased cell death in HCT116  Increased colony dispersion (i 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ephb4):
     cardiovascular system  embryogenesis  growth/size/body  mortality/aging  muscle 

    Find genes that share phenotypes with EPHB4           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EPHB4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EPHB4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EPHB4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EPHB4

    miRNA
    Products:
        
    miRTarBase miRNAs that target EPHB4:
    hsa-mir-20b-5p (MIRT006338), hsa-mir-1260b (MIRT052757), hsa-mir-93-3p (MIRT038783), hsa-mir-335-5p (MIRT017978)

    Block miRNA regulation of human, mouse, rat EPHB4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EPHB4 (see all 39):
    hsa-miR-300 hsa-miR-106a hsa-miR-3653 hsa-miR-624 hsa-miR-301a hsa-miR-519a hsa-miR-124 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidEPHB4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EPHB4
    Predesigned siRNA for gene silencing in human, mouse, rat EPHB4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EPHB4

    Clone
    Products:
         
    OriGene clones in human, mouse for EPHB4 (see all 9)
    OriGene ORF clones in mouse, rat for EPHB4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EPHB4 (NM_004444)
    Sino Biological Human cDNA Clone for EPHB4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHB4
    Addgene plasmids for EPHB4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for EPHB4
    Browse ESI BIO Cell Lines and PureStem Progenitors for EPHB4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHB4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    EPHB4_HUMAN, P54760: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytoskeleton1
    cytosol1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane IDA8188704

    Find genes that share ontologies with EPHB4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for EPHB4 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    Ephrin-Eph Signaling0.58
    2EPHB forward signaling
    EPHB forward signaling0.30
    EphrinB-EPHB pathway0.00
    Cell adhesion Ephrins signaling0.30
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48


    Find genes that share SuperPaths with EPHB4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EPHB4 (see all 31)
        MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Ephrin-Eph Signaling

    2 GeneGo (Thomson Reuters) Pathways for EPHB4
        Cytoskeleton remodeling Reverse signaling by ephrin B
    Cell adhesion Ephrins signaling

    3 BioSystems Pathways for EPHB4
        Ephrin B reverse signaling
    EPHB forward signaling
    EphrinB-EPHB pathway



    1 Kegg Pathway  (Kegg details for EPHB4):
        Axon guidance

        Pathway & Disease-focused RT2 Profiler PCR Array including EPHB4: 
              Angiogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for EPHB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for EPHB4 (P547603 ENSP000003508964) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRIN1Q055863, ENSP000003606164I2D: score=2 STRING: ENSP00000360616
    SDC3O750563, ENSP000003444684I2D: score=2 STRING: ENSP00000344468
    EFNB2P527993, ENSP000002453234I2D: score=1 STRING: ENSP00000245323
    JUNP054123, ENSP000003602664I2D: score=1 STRING: ENSP00000360266
    EGFRP005333, ENSP000002754934I2D: score=1 STRING: ENSP00000275493
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis ISS--
    GO:0002042cell migration involved in sprouting angiogenesis IDA12734395
    GO:0003007heart morphogenesis ISS--
    GO:0006468protein phosphorylation ----
    GO:0007155cell adhesion IDA12734395

    Find genes that share ontologies with EPHB4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for EPHB4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GTP 14564Class III receptor tyrosine kinase (RTK) inhibitor[34823-86-4]
    NVP BHG 712Potent EphB4 kinase inhibitor[940310-85-0]
    Ki 20227c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation[623142-96-1]

    2 HMDB Compounds for EPHB4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    8 DrugBank Compounds for EPHB4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3-({4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZAMIDE-- --target--10592235
    3-({4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzenesulfonamide-- --target--10592235
    N'-(3-CHLORO-4-METHOXY-PHENYL)-N-(3,4,5-TRIMETHOXYPHENYL)-1,3,5-TRIAZINE-2,4-DIAMINE-- --target--10592235
    N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3,4,5- TRIMETHOXYPHENYL)PYRIMIDINE-2,4-DIAMINE-- --target--10592235
    N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3-MORPHOLIN-4-YLPHENYL)PYRIMIDINE-2,4-DIAMINE-- --target--10592235
    N'-(5-chloro-1,3-benzodioxol-4-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine-- --target--10592235
    N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine-- --target--10592235
    N-[3-[[4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL]AMINO]PHENYL]METHANESULFONAMIDE-- --target--10592235

    3 Novoseek inferred chemical compound relationships for EPHB4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 66 35 8188704 (4), 10221518 (3), 15358160 (2), 16816380 (2) (see all 16)
    vegf 40.8 10 20338920 (3), 19950560 (1), 19923070 (1), 15471957 (1) (see all 6)
    thymidine 38.9 9 7593001 (2), 7969135 (1), 10502302 (1), 10639574 (1) (see all 6)



    Find genes that share compounds with EPHB4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for EPHB4 gene: 
    NM_004444.4  

    Unigene Cluster for EPHB4:

    EPH receptor B4
    Hs.437008  [show with all ESTs]
    Unigene Representative Sequence: AB209644
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360620 ENST00000358173(uc003uwn.1 uc010lhj.1 uc011kkf.1 uc011kkg.1 uc011kkh.1)
    ENST00000487222(uc003uwm.1) ENST00000492403 ENST00000478459 ENST00000467515
    ENST00000477446 ENST00000489808 ENST00000492878
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EPHB4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EPHB4 (see all 39):
    hsa-miR-300 hsa-miR-106a hsa-miR-3653 hsa-miR-624 hsa-miR-301a hsa-miR-519a hsa-miR-124 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidEPHB4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for EPHB4
    Predesigned siRNA for gene silencing in human, mouse, rat EPHB4
    Clone
    Products:
         
    OriGene clones in human, mouse for EPHB4 (see all 9)
    OriGene ORF clones in mouse, rat for EPHB4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: EPHB4 (NM_004444)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHB4
    Addgene plasmids for EPHB4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for EPHB4
    OriGene qSTAR qPCR primer pairs in human, mouse for EPHB4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EPHB4
      QuantiTect SYBR Green Assays in human, mouse, rat EPHB4
      QuantiFast Probe-based Assays in human, mouse, rat EPHB4

    Additional mRNA sequence: 

    AB209644.1 AK301224.1 AY056048.1 BC004264.1 BC052804.1 EU826608.1 EU826609.1 EU826610.1 
    U07695.1 

    12 DOTS entries:

    DT.100689231  DT.100818782  DT.444136  DT.121068866  DT.100818780  DT.121068891  DT.95282899  DT.121068837 
    DT.97845932  DT.91914735  DT.95081702  DT.95282873 

    Selected AceView cDNA sequences (see all 188):

    BM929429 BM790755 BE466828 BM830054 AV708776 AW083751 BM823021 H89196 
    BM766839 AY056048 BM742052 AW276575 BM766176 BM756028 AA369508 BM757081 
    BM974102 BM857398 AA659141 BM852162 AA299650 BU683397 BM795543 AI270622 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for EPHB4 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17
    SP1:              -                                               -                 -                                                               
    SP2:              -                                               -                 -                                                     -         
    SP3:                                                              -                 -                                                               
    SP4:                                                                                -                                                               
    SP5:                                                                                                  -                                             


    ECgene alternative splicing isoforms for EPHB4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    EPHB4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGTTTCCA
    EPHB4 Expression
    About this image


    EPHB4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 4 entries
             Venous Endothelial Cells Pulmonary Capillary Plexus
             Endothelial-like cells
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Venous Endothelial Cells Pulmonary Capillary Plexus
     
     Heart (Cardiovascular System)
             Venous Endothelial Cells Cardinal Veins
     
     NULL (Uncategorized)
             Endothelial-like cells
    EPHB4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EPHB4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437008

    UniProtKB/Swiss-Prot: EPHB4_HUMAN, P54760
    Tissue specificity: Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal
    muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in
    cell lines derived from liver, breast, colon, lung, melanocyte and cervix

        Pathway & Disease-focused RT2 Profiler PCR Array including EPHB4: 
              Angiogenesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for EPHB4
    OriGene qSTAR qPCR primer pairs in human, mouse for EPHB4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EPHB4
    QuantiTect SYBR Green Assays in human, mouse, rat EPHB4
    QuantiFast Probe-based Assays in human, mouse, rat EPHB4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHB4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for EPHB4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ephb41 , 5 Eph receptor B41, 5 86.47(n)1
    93.11(a)1
      5 (76.38 cM)5
    138461  NM_001159571.11  NP_001153043.11 
     1373501095 
    African clawed frog
    (Xenopus laevis)
    Amphibia ephB4a2 eph receptor tyrosine kinase 75.82(n)    AJ236867.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AJ005026.22   -- 78.6(n)   30688  AJ005026.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Eph3 protein amino acid phosphorylation
    transmembrane more
    38(a)
    (best of 2)
      102C2   --


    ENSEMBL Gene Tree for EPHB4 (if available)
    TreeFam Gene Tree for EPHB4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for EPHB4 gene
    EPHB12  EPHA22  EPHB32  EPHA42  EPHA52  EPHB62  EPHA62  EPHA12  
    EPHB22  EPHA82  EPHA32  EPHA72  EPHA102  
    Selected SIMAP similar genes for EPHB4 using alignment to 7 protein entries:     EPHB4_HUMAN (see all proteins) (see all similar genes):
    EPHB3    EPHB1    EPHB2 variant protein    EPHA2    EPHA3    EPHA4
    EPHA7    EPHB2    EPHA6    EPHA8    FRK    EPHA5
    HCK    YES1    EPHA10    EPHB6    LCK    LYN

    Find genes that share paralogs with EPHB4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for EPHB4 (see all 754)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0421884
    A gastric adenocarcinoma sample4--see VAR_0421882 R W mis40--------
    VAR_0421834
    A metastatic melanoma sample4--see VAR_0421832 P L mis40--------
    rs2004882591,2
    C--95055009(+) CCCCC-/CGCAAGG 1 -- int10--------
    rs1149419421,2
    C--100399695(+) CACACA/GTGGGG 1 -- ds50010--------
    rs746262601,2
    C,F--100399697(+) CACGTG/TGGGGG 1 -- ds50011Minor allele frequency- T:0.10WA 118
    rs117732811,2
    H--100399704(+) GGGGGG/TCCCTT 1 -- ds50010--------
    rs559822651,2
    C,F--100399802(+) TCCATC/TCACGG 1 -- ds50013Minor allele frequency- T:0.08WA NA EA 358
    rs1489635661,2
    --100399805(+) ATCCAC/TGGAAC 1 -- ds50010--------
    rs1909626041,2
    --100400105(+) TCCAGA/CCCTCT 1 -- ds50010--------
    rs559455031,2
    C--100400124(+) TCGGTA/C/GAGCCA 1 -- ds50015WA CSA NA EA 362

    HapMap Linkage Disequilibrium report for EPHB4 (100400187 - 100425143 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for EPHB4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    dgv7403n71CNV Loss21882294
    dgv7402n71CNV Loss21882294
    nsv470381CNV Loss18288195
    nsv888800CNV Loss21882294
    nsv888796CNV Loss21882294
    dgv2119e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EPHB4
    DNA2.0 Custom Variant and Variant Library Synthesis for EPHB4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600011    OMIM disorders: --

    1 disease for EPHB4:    
    About MalaCards
    prostate cancer

    1 disease from the University of Copenhagen DISEASES database for EPHB4:
    Cancer

    Find genes that share disorders with EPHB4           About GenesLikeMe

    Selected Novoseek inferred disease relationships for EPHB4 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinal neovascularization 61.7 1 15914639 (1)
    neovascularization 52.9 2 17133777 (1), 17510705 (1)
    hnscc 47 24 16615113 (4), 17043250 (4), 18794445 (4), 14661437 (2)
    cancer 32.9 14 19552627 (3), 17108150 (1), 19879134 (1), 17241664 (1) (see all 9)
    proliferative diabetic retinopathy 31.3 1 17133777 (1)
    tumors 29.5 59 16816380 (4), 19366806 (4), 16615113 (3), 20133814 (3) (see all 26)
    endometrial carcinoma 25.2 4 11295082 (2), 12562648 (1)
    carcinoma squamous cell 24.1 8 16615113 (2), 17043250 (2), 18794445 (2), 17611172 (1) (see all 5)
    retinopathy 21.2 5 15914639 (2), 15289137 (1), 20503366 (1), 19232363 (1)
    ovarian cancer 20 10 18231102 (4), 17353927 (2), 18281782 (2)

    Genetic Association Database (GAD): EPHB4
    Human Genome Epidemiology (HuGE) Navigator: EPHB4 (1 document)

    Export disorders for EPHB4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for EPHB4 gene, integrated from 10 sources (see all 177) (see top 10):
    (articles sorted by number of sources associating them with EPHB4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily. (PubMed id 8188704)1, 2, 3, 9 Bennett B.D.... Scadden D.T. (J. Biol. Chem. 1994)
    2. Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells. (PubMed id 12734395)1, 2, 9 Fueller T.... Augustin H.G. (J. Cell Sci. 2003)
    3. Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity. (PubMed id 16867992)1, 2, 9 Chrencik J.E.... Kuhn P. (J. Biol. Chem. 2006)
    4. EphB4 controls blood vascular morphogenesis during postnatal angiogenesis. (PubMed id 16424904)1, 2, 9 Erber R.... Vajkoczy P. (EMBO J. 2006)
    5. EPHB4 gene polymorphisms and risk of intracranial hemorrhage in patients with brain arteriovenous malformations. (PubMed id 20031623)1, 4 Weinsheimer S....Young W.L. (Circ Cardiovasc Genet 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. (PubMed id 11239002)1, 2 Wilson M.D.... Koop B.F. (Nucleic Acids Res. 2001)
    8. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PubMed id 9267020)1, 2 (Cell 1997)
    9. Receptor tyrosine kinase, EphB4 (HTK), accelerates differentiation of select human hematopoietic cells. (PubMed id 11929761)1, 9 Wang Z....Scadden D.T. (Blood 2002)
    10. EphB4 expression and biological significance in prostate cancer. (PubMed id 15930280)1, 9 Xia G....Gill P.S. (Cancer Res. 2005)
    11. The receptor tyrosine kinase EphB4 is overexpressed in ovarian cancer, provides survival signals and predicts poor outcome. (PubMed id 17353927)1, 9 Kumar S.R....Gill P.S. (Br. J. Cancer 2007)
    12. Coexpression of EphB4 and ephrinB2 in tumor advancement of uterine cervical cancers. (PubMed id 19356789)1, 9 Alam S.M....Tamaya T. (Gynecol. Oncol. 2009)
    13. Ephrin-independent regulation of cell substrate adhesion by the EphB4 receptor. (PubMed id 19552627)1, 9 Noren N.K....Pasquale E.B. (Biochem. J. 2009)
    14. Coexpression of EphB4 and ephrinB2 in tumour advancement of ovarian cancers. (PubMed id 18231102)1, 9 Alam S.M....Tamaya T. (Br. J. Cancer 2008)
    15. EphB4 provides survival advantage to squamous cell carcinoma of the head and neck. (PubMed id 16615113)1, 9 Masood R....Gill P.S. (Int. J. Cancer 2006)
    16. Novel EphB4 monoclonal antibodies modulate angiogenesis and inhibit tumor growth. (PubMed id 20133814)1, 9 Krasnoperov V....Gill P.S. (Am. J. Pathol. 2010)
    17. Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression. (PubMed id 19366806)1, 9 Kumar S.R....Gill P.S. (Cancer Res. 2009)
    18. PSGL-1-mediated activation of EphB4 increases the proangiogenic potential of endothelial progenitor cells. (PubMed id 17510705)1, 9 Foubert P....Le Ricousse-Roussanne S. (J. Clin. Invest. 2007)
    19. Cell adhesion to ephrinb2 is induced by EphB4 independently of its kinase activity. (PubMed id 15358160)1, 9 Sakamoto H....Suda T. (Biochem. Biophys. Res. Commun. 2004)
    20. Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia. (PubMed id 20061560)1, 9 Kuang S.Q....Garcia-Manero G. (Blood 2010)
    21. BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB4. (PubMed id 20002159)1, 9 Suzuki M....Naoe T. (Eur. J. Haematol. 2010)
    22. The ephrinB2/EphB4 axis is dysregulated in osteoprogenitors from myeloma patients and its activation affects myeloma bone disease and tumor growth. (PubMed id 19597185)1, 9 Pennisi A....Yaccoby S. (Blood 2009)
    23. Investigation of the expression of the EphB4 receptor tyrosine kinase in prostate carcinoma. (PubMed id 16171530)1, 9 Lee Y.C....Stephenson S.A. (BMC Cancer 2005)
    24. Homeobox A9 transcriptionally regulates the EphB4 receptor to modulate endothelial cell migration and tube formation. (PubMed id 14764452)1, 9 Bruhl T....Dimmeler S. (Circ. Res. 2004)
    25. Expression and prognostic significance of EFNB2 and EphB4 genes in patients with oesophageal squamous cell carcinoma. (PubMed id 17611172)1, 9 Tachibana M....Yoshimura H. (Dig Liver Dis 2007)
    26. EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodeling. (PubMed id 16840724)1, 9 Salvucci O....Tosato G. (Blood 2006)
    27. Differential expression of the receptor tyrosine kinase EphB4 and its ligand Ephrin-B2 during human placental development. (PubMed id 16343615)1, 9 Chennakesava C.S....Andres A.C. (Placenta 2006)
    28. Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity. (PubMed id 16472751)2, 9 Chrencik J.E....Kuhn P. (Structure 2006)
    29. Syndecan-1 up-regulated by ephrinB2/EphB4 plays dual roles in inflammatory angiogenesis. (PubMed id 15126321)1, 9 Yuan K....Lin M.T. (Blood 2004)
    30. Expression of the receptor protein tyrosine kinase myk-1/htk in normal and malignant mammary epithelium. (PubMed id 8831703)1, 9 Berclaz G....Crompton M.R. (Biochem. Biophys. Res. Commun. 1996)
    31. Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes. (PubMed id 19664212)1, 9 Kwan Tat S....Martel-Pelletier J. (amp 2009)
    32. Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts. (PubMed id 19035475)1, 9 Kwan Tat S....Martel-Pelletier J. (Arthritis Rheum. 2008)
    33. Notch ligand Delta-like 1 is essential for postnatal arteriogenesis. (PubMed id 17234965)1, 9 Limbourg A....Limbourg F.P. (Circ. Res. 2007)
    34. Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the phosphatidylinositol 3-kinase pathway. (PubMed id 12235151)1, 9 Steinle J.J....Granger H.J. (J. Biol. Chem. 2002)
    35. Coexpression of ephrin-Bs and their receptors in colon carcinoma. (PubMed id 11920461)1, 9 Liu W....Ellis L.M. (Cancer 2002)
    36. Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. (PubMed id 10518221)1, 9 Gerety S.S....Anderson D.J. (Mol. Cell 1999)
    37. EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity. (PubMed id 15722342)1, 9 Koolpe M....Pasquale E.B. (J. Biol. Chem. 2005)
    38. Eph and ephrin expression in normal placental development and preeclampsia. (PubMed id 15193868)1, 9 Goldman-Wohl D....Yagel S. (Placenta 2004)
    39. High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion. (PubMed id 23295955)1 Lehtinen L....Iljin K. (Oncotarget 2013)
    40. EphB4 as a therapeutic target in mesothelioma. (PubMed id 23721559)1 Liu R....Krasnoperov V. (BMC Cancer 2013)
    41. Clinical implications of EphB4 receptor expression in pancreatic cancer. (PubMed id 23079712)1 Li M. and Zhao Z. (Mol. Biol. Rep. 2013)
    42. Critical role for the receptor tyrosine kinase EPHB4 in esophageal cancers. (PubMed id 23100466)1 Hasina R....Salgia R. (Cancer Res. 2013)
    43. Eph receptor B4 is a regulator of estrogen receptor alpha in breast cancer cells. (PubMed id 23725356)1 Schmitt F....Mayer D. (J. Recept. Signal Transduct. Res. 2013)
    44. Correlation between erythropoietin receptor(s) and estrogen and progesterone receptor expression in different breast cancer cell lines. (PubMed id 23314808)1 TroA!t N....Debeljak N. (Int. J. Mol. Med. 2013)
    45. Gene expression profiling identifies EPHB4 as a potential predictive biomarker in colorectal cancer patients treated with bevacizumab. (PubMed id 23579861)1 Guijarro-MuA+oz I....Sanz L. (Med. Oncol. 2013)
    46. The EphB4 receptor tyrosine kinase promotes lung cancer growth: a potential novel therapeutic target. (PubMed id 23844053)1 Ferguson B.D....Salgia R. (PLoS ONE 2013)
    47. EphB4 is overexpressed in gliomas and promotes the growth of glioma cells. (PubMed id 23138393)1 Chen T....Liu Z. (Tumour Biol. 2013)
    48. Copy number variation in ACHE/EPHB4 (7q22) and in BCHE/MME (3q26) genes in sporadic breast cancer. (PubMed id 23063927)1 Boberg D.R....Souza R.L. (Chem. Biol. Interact. 2013)
    49. Targeting the EphB4 receptor for cancer diagnosis and therapy monitoring. (PubMed id 23211050)1 Li D....Conti P.S. (Mol. Pharm. 2013)
    50. EphB4 is overexpressed in papillary thyroid carcinoma and promotes the migration of papillary thyroid cancer cells. (PubMed id 22528941)1 Xuqing W....Jianxin Z. (Tumour Biol. 2012)
    51. Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. (PubMed id 22990020)1 Huang J....Hamsten A. (Blood 2012)
    52. Relationships among differentiation degree, contrast-enhanced ultrasound and the expression of Ephb4/Ephrinb2 in primary hepatocarcinoma. (PubMed id 22024229)1 Zhu X.L....Zhang N. (Hepatogastroenterology 2012)
    53. Expression of EphrinB2 and EphB4 in glioma tissues correlated to the progression of glioma and the prognosis of glioblastoma patients. (PubMed id 22374425)1 Tu Y....Deng J. (amp 2012)
    54. EphB4 gene polymorphism and protein expression in non-small-cell lung cancer. (PubMed id 22684742)1 Zheng M.F....Chen J.Y. (Mol Med Rep 2012)
    55. Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome. (PubMed id 21935409)1 Brantley-Sieders D.M....Chen J. (PLoS ONE 2011)
    56. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    57. [Relationship between multi-slice spiral CT pulmonary perfusion imaging and the expression of EphB4 and ephrinB2 in non-small cell lung cancer]. (PubMed id 21575518)1 Xiong Z....Chen W. (Zhonghua Zhong Liu Za Zhi 2011)
    58. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    59. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    60. Distribution of EphB4 and EphrinB2 in normal and malignant urogenital tissue. (PubMed id 19272799)1 OzgA1r E....Bloch W. (Urol. Oncol. 2011)
    61. Over-expression of Ephb4 is associated with carcinogenesis of gastric cancer. (PubMed id 20686847)1 Li M....Xin Y. (Dig. Dis. Sci. 2011)
    62. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    63. The EphB6 receptor cooperates with c-Cbl to regulate the behavior of breast cancer cells. (PubMed id 20086179)1 Truitt L....Freywald A. (Cancer Res. 2010)
    64. EphB4 promotes site-specific metastatic tumor cell dissemination by interacting with endothelial cell-expressed ephrinB2. (PubMed id 21047731)1 HAcroult M....Augustin H.G. (Mol. Cancer Res. 2010)
    65. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    66. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    67. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (Mol. Cell. Proteomics 2009)
    68. Involvement of endothelial ephrin-B2 in adhesion and transmigration of EphB-receptor-expressing monocytes. (PubMed id 18957513)1 Pfaff D....Augustin H.G. (J. Cell. Sci. 2008)
    69. Cytochrome P450 2C9-induced angiogenesis is dependent on EphB4. (PubMed id 18340006)1 Webler A.C....Fleming I. (Arterioscler. Thromb. Vasc. Biol. 2008)
    70. Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. (PubMed id 18593464)1 Jin P.... Paleolog E.M. (Arthritis Res. Ther. 2008)
    71. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (Mol. Cell 2008)
    72. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    73. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (Nature 2007)
    74. Expression of Eph B4 and Ephrin B2 in cervical cancer tissues and angiogenesis. (PubMed id 17196593)1 Zhang S....Liang M. (Int J Gynaecol Obstet 2007)
    75. EPHB4 and survival of colorectal cancer patients. (PubMed id 16982731)1 Davalos V....Arango D. (Cancer Res. 2006)
    76. The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth. (PubMed id 16322467)1 Kertesz N....Gill P.S. (Blood 2006)
    77. EphB4 receptor tyrosine kinase is expressed in bladder cancer and provides signals for cell survival. (PubMed id 16205642)1 Xia G....Gill P.S. (Oncogene 2006)
    78. EPHB4 regulates chemokine-evoked trophoblast responses: a mechanism for incorporating the human placenta into the maternal circulation. (PubMed id 16107476)1 Red-Horse K....Fisher S.J. (Development 2005)
    79. Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. (PubMed id 15951569)1 Zhang Y.... White F.M. (Mol. Cell. Proteomics 2005)
    80. Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. (PubMed id 12493773)1 Shin B.K....Hanash S.M. (J. Biol. Chem. 2003)
    81. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (Science 2003)
    82. A role of EphB4 receptor and its ligand, ephrin-B2, in erythropoiesis. (PubMed id 12051776)1 Suenobu S....Suda T. (Biochem. Biophys. Res. Commun. 2002)
    83. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    84. Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells. (PubMed id 11466354)1 Luo H....Wu J. (J. Immunol. 2001)
    85. Multiple roles of EPH receptors and ephrins in neural development. (PubMed id 11256076)1 Wilkinson D.G. (Nat. Rev. Neurosci. 2001)
    86. Roles of Eph receptors and ephrins in segmental patterning. (PubMed id 11128993)1 Xu Q....Wilkinson D.G. (Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2000)
    87. Eph receptors and ephrins: regulators of guidance and assembly. (PubMed id 10730216)1 Wilkinson D.G. (Int. Rev. Cytol. 2000)
    88. EphB receptors interact with NMDA receptors and regulate excitatory synapse formation. (PubMed id 11136979)1 Dalva M.B....Greenberg M.E. (Cell 2000)
    89. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (Nucleic Acids Res. 2000)
    90. Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma. (PubMed id 10037197)1 Tang X.X....Ikegaki N. (Clin. Cancer Res. 1999)
    91. Eph receptors and ephrins: effectors of morphogenesis. (PubMed id 10207129)1 Holder N. and Klein R. (Development 1999)
    92. Cell-type specific and estrogen dependent expression of the receptor tyrosine kinase EphB4 and its ligand ephrin-B2 during mammary gland morphogenesis. (PubMed id 9718367)1 Nikolova Z....Ziemiecki A. (J. Cell. Sci. 1998)
    93. The Eph family receptors and ligands. (PubMed id 9576626)1 Zhou R. (amp 1998)
    94. The ephrins and Eph receptors in neural development. (PubMed id 9530499)1 Flanagan J.G. and Vanderhaeghen P. (Annu. Rev. Neurosci. 1998)
    95. Phosphorylation of recombinant N-syndecan (syndecan 3) core protein. (PubMed id 9388509)1 Asundi V.K. and Carey D.J. (Biochem. Biophys. Res. Commun. 1997)
    96. Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis. (PubMed id 8152808)1 Andres A.C....Ziemiecki A. (Oncogene 1994)
    97. Overexpression of ephrinB2 and EphB4 in tumor advancement of uterine endometrial cancers. (PubMed id 17108150)9 Alam S.M....Tamaya T. (Ann. Oncol. 2007)
    98. The association between elevated EphB4 expression, smoking status, and advanced-stage disease in patients with head and neck squamous cell carcinoma. (PubMed id 17043250)9 Sinha U.K....Gill P.S. (amp 2006)
    99. The significance of EphB4 and EphrinB2 expression and survival in head and neck squamous cell carcinoma. (PubMed id 18794445)9 Yavrouian E.J....Masood R. (amp 2008)
    100. Expression of receptor tyrosine kinase HTK (hepatoma transmembrane kinase) and HTK ligand by human leukemia-lymphoma cell lines. (PubMed id 10221518)9 Steube K.G....Drexler H.G. (amp 1999)
    101. Soluble EphB4 inhibition of PDGF-induced RPE migration in vitro. (PubMed id 19696168)9 He S....Hinton D.R. (amp 2010)
    102. NF-Y-mediated trans-activation of the human thymidine kinase promoter is closely linked to activation of cyclin-dependent kinase. (PubMed id 10502302)9 Chang Z.F....Hu S.F. (J. Cell. Biochem. 1999)
    103. Ephrin B2/EphB4 pathway in hepatic stellate cells stimulates Erk-dependent VEGF production and sinusoidal endothelial cell recruitment. (PubMed id 20338920)9 Das A....Shah V.H. (Am. J. Physiol. Gastrointest. Liver Physiol. 2010)
    104. Expression of Ephb2 and Ephb4 in breast carcinoma. (PubMed id 15029258)9 Wu Q....Nesland J.M. (Pathol. Oncol. Res. 2004)
    105. Degradation of human thymidine kinase is dependent on serine-13 phosphorylation: involvement of the SCF-mediated pathway. (PubMed id 12435275)9 Ke P.Y....Chang Z.F. (Biochem. J. 2003)
    106. Different regulation of the human thymidine kinase promoter in normal human diploid IMR-90 fibroblasts and HeLa cells. (PubMed id 7593001)9 Chang Z.F....Lai T.C. (J. Biol. Chem. 1995)
    107. Receptor tyrosine kinase EphB4 is a survival factor in breast cancer. (PubMed id 16816380)9 Kumar S.R....Gill P.S. (Am. J. Pathol. 2006)
    108. EphB4 signaling is capable of mediating ephrinB2-induced inhibition of cell migration. (PubMed id 14672701)9 Sturz A....Glienke J. (Biochem. Biophys. Res. Commun. 2004)
    109. Expression of EphB4 in head and neck squamous cell carcinoma. (PubMed id 14661437)9 Sinha U.K....Gill P.S. (amp 2003)
    110. Activation of the receptor protein tyrosine kinase EphB4 in endometrial hyperplasia and endometrial carcinoma. (PubMed id 12562648)9 Berclaz G....Andres A.C. (Ann. Oncol. 2003)
    111. Loss of EphB4 receptor tyrosine kinase protein expression during carcinogenesis of the human breast. (PubMed id 12168060)9 Berclaz G....Andres A.C. (Oncol. Rep. 2002)
    112. EphrinB2 and EphB4 expression in pterygia: new insights and preliminary results. (PubMed id 19491953)9 Xue C....Zhou X. (Can. J. Ophthalmol. 2009)
    113. Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design. (PubMed id 17062140)9 El Omari K....Stammers D.K. (BMC Struct. Biol. 2006)
    114. Soluble forms of EphrinB2 and EphB4 reduce retinal neovascularization in a model of proliferative retinopathy. (PubMed id 15914639)9 Zamora D.O....Powers M.R. (amp 2005)
    115. Expression of Tie-2, angiopoietin-1, angiopoietin-2, ephrinB2 and EphB4 in pyogenic granuloma of human gingiva implicates their roles in inflammatory angiogenesis. (PubMed id 10929871)9 Yuan K....Lin M.T. (J. Periodont. Res. 2000)
    116. Altered vascular expression of EphrinB2 and EphB4 in a model of oxygen-induced retinopathy. (PubMed id 20503366)9 Davies M.H....Powers M.R. (Dev. Dyn. 2010)
    117. Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4). (PubMed id 19788238)9 Lafleur K....Nevado C. (J. Med. Chem. 2009)
    118. Ephrin B2 expression in Kaposi sarcoma is induced by human herpesvirus type 8: phenotype switch from venous to arterial endothelium. (PubMed id 15471957)9 Masood R....Gill P.S. (Blood 2005)
    119. Kinase recognition by calmodulin: modeling the interaction with the autoinhibitory region of human cardiac titin kinase. (PubMed id 11178895)9 Amodeo P....Motta A. (J. Mol. Biol. 2001)
    120. Stromal cells expressing ephrin-B2 promote the growth and sprouting of ephrin-B2(+) endothelial cells. (PubMed id 11493448)9 Zhang X.Q....Suda T. (Blood 2001)
    121. Communication between ephrinB2 and EphB4 within the osteoblast lineage. (PubMed id 19950015)9 Martin T.J....Sims N.A. (Adv. Exp. Med. Biol. 2010)
    122. Altered expression patterns of EphrinB2 and EphB2 in human umbilical vessels and congenital venous malformations. (PubMed id 15718372)9 Diehl S....Klein R. (Pediatr. Res. 2005)
    123. Akt/protein kinase B and endothelial nitric oxide synthase mediate muscular neovascularization induced by tissue kallikrein gene transfer. (PubMed id 15364809)9 Emanueli C....Madeddu P. (Circulation 2004)
    124. Ephrin receptor, EphB4, regulates ES cell differentiation of primitive mammalian hemangioblasts, blood, cardiomyocytes, and blood vessels. (PubMed id 12958066)9 Wang Z....Scadden D.T. (Blood 2004)
    125. Inhibition of tumor growth and angiogenesis by soluble EphB4. (PubMed id 15153337)9 Martiny-Baron G....Augustin H.G. (Neoplasia 2004)
    126. Distinct roles of ephrin-B2 forward and EphB4 reverse signaling in endothelial cells. (PubMed id 12588758)9 Hamada K....Suda T. (Arterioscler. Thromb. Vasc. Biol. 2003)
    127. Prevention of diabetes-induced microangiopathy by human tissue kallikrein gene transfer. (PubMed id 12186806)9 Emanueli C....Madeddu P. (Circulation 2002)
    128. Expression of receptor tyrosine kinase EphB4 and its ligand ephrin-B2 is associated with malignant potential in endometrial cancer. (PubMed id 11295082)9 Takai N....Miyakawa I. (Oncol. Rep. 2001)
    129. Type-2 diabetic Lepr(db/db) mice show a defective microvascular phenotype under basal conditions and an impaired response to angiogenesis gene therapy in the setting of limb ischemia. (PubMed id 17127438)9 Emanueli C....Madeddu P. (Front. Biosci. 2007)
    130. Regional and global protective effects of tissue kallikrein gene delivery to the peri-infarct myocardium. (PubMed id 17465807)9 Spillmann F....Madeddu P. (Regen Med 2006)
    131. [Detecting protein expression of EphrinB2 ligand and its receptor EphB4 in astrocytoma using confocal laser scanning microscopy]. (PubMed id 15473927)9 Xiao H.L....Wang D. (Ai Zheng 2004)
    132. Optimisation of the RT-PCR detection of immunomagnetically enriched carcinoma cells. (PubMed id 12031094)9 Raynor M....Dobrovic A. (BMC Cancer 2002)
    133. Eph and ephrin interactions in bone. (PubMed id 19950019)9 Matsuo K. (Adv. Exp. Med. Biol. 2010)
    134. Fluid shear stress induces arterial differentiation of endothelial progenitor cells. (PubMed id 18988767)9 Obi S....Ando J. (J. Appl. Physiol. 2009)
    135. Imidazo[1,2-a]pyrazine diaryl ureas: inhibitors of the receptor tyrosine kinase EphB4. (PubMed id 19879134)9 Mitchell S.A....Elkin L.L. (amp 2009)
    136. [Mesh structure of two-dimensional tumor microvascular architecture phenotype heterogeneity in non-small cell lung cancer]. (PubMed id 19923070)9 Xiong Z....Zhou J.H. (Nan Fang Yi Ke Da Xue Xue Bao 2009)
    137. The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade. (PubMed id 18836096)9 Scehnet J.S....Gill P.S. (Blood 2009)
    138. Crystal structure and NMR binding reveal that two small molecule antagonists target the high affinity ephrin-binding channel of the EphA4 receptor. (PubMed id 18708347)9 Qin H.... Song J. (J. Biol. Chem. 2008)
    139. Discovery of kinase inhibitors by high-throughput docking and scoring based on a transferable linear interaction energy model. (PubMed id 18271520)9 Kolb P....Caflisch A. (J. Med. Chem. 2008)
    140. Brothers and sisters: molecular insights into arterial-venous heterogeneity. (PubMed id 18948631)9 Aitsebaomo J....Patterson C. (Circ. Res. 2008)
    141. The EPH receptor Bs (EPHBs) promoters are unmethylated in colon and ovarian cancers. (PubMed id 18281782)9 Wu Q....Suo Z. (Epigenetics 2007)
    142. Framework shuffling of antibodies to reduce immunogenicity and manipulate functional and biophysical properties. (PubMed id 17241664)9 Damschroder M.M....Wu H. (Mol. Immunol. 2007)
    143. Paradoxes of the EphB4 receptor in cancer. (PubMed id 17483308)9 Noren N.K. and Pasquale E.B. (Cancer Res. 2007)
    144. Expression of ephrin in retinal neovascularization and iris rubeosis. (PubMed id 17133777)9 Yuuki T....Kishi S. (J. Int. Med. Res. 2006)
    145. Human leukocytes express ephrinB2 which activates microvascular endothelial cells. (PubMed id 17123494)9 Zamora D.O....Rosenbaum J.T. (Cell. Immunol. 2006)
    146. Putative dual role of ephrin-Eph receptor interactions in inflammation. (PubMed id 16801213)9 Ivanov A.I. and Romanovsky A.A. (IUBMB Life 2006)
    147. The prognostic impact of EphB2/B4 expression on patients with advanced ovarian carcinoma. (PubMed id 16499955)9 Wu Q....Nesland J.M. (Gynecol. Oncol. 2006)
    148. New potential ligand-receptor signaling loops in ovarian cancer identified in multiple gene expression studies. (PubMed id 17090524)9 Castellano G....Canevari S. (Cancer Res. 2006)
    149. Dll4-selective Notch signaling induces ephrinB2 gene expression in endothelial cells. (PubMed id 16430858)9 Iso T....Kurabayashi M. (Biochem. Biophys. Res. Commun. 2006)
    150. Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells. (PubMed id 15657067)9 Thelemann A....Haley J.D. (amp 2005)
    151. Down-regulation of endothelial ephrinB2 expression by laminar shear stress. (PubMed id 15763946)9 Goettsch W....Morawietz H. (Endothelium 2004)
    152. The relationship between oncogene expression and clinical outcome in endometrial carcinoma. (PubMed id 15379636)9 Takai N....Miyakawa I. (Curr Cancer Drug Targets 2004)
    153. Expression of ephrinB2 and its receptors on fibroproliferative membranes in ocular angiogenic diseases. (PubMed id 15289137)9 Umeda N....Oshima K. (Am. J. Ophthalmol. 2004)
    154. Inhibitory and enhancing effects of insertion of central polypurine tract sequence on gene expression with vectors derived from human immunodeficiency virus type 1. (PubMed id 12615060)9 Sakuma R....Kitamura Y. (Biochem. Biophys. Res. Commun. 2003)
    155. Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung. (PubMed id 12842817)9 Favre C.J....McDonald D.M. (Am. J. Physiol. Heart Circ. Physiol. 2003)
    156. Regulation of thymidine kinase expression during cellular senescence. (PubMed id 11287748)9 Chang Z.F. and Huang D.Y. (J. Biomed. Sci. 2001)
    157. Receptor protein tyrosine kinase EphB4 is up-regulated in colon cancer. (PubMed id 11801186)9 Stephenson S.A....Hardingham J.E. (BMC Mol. Biol. 2001)
    158. Regulation of the activity and polymerization status of recombinant human cytosolic thymidine kinase by thiols and ATP. (PubMed id 10639574)9 Kuroiwa N....Fujimura S. (Int. J. Oncol. 2000)
    159. The bystander effect in the HSVtk/ganciclovir system and its relationship to gap junctional communication. (PubMed id 10023450)9 Touraine R.L....Blaese R.M. (Gene Ther. 1998)
    160. Characterization of a ligand for receptor protein-tyrosine kinase HTK expressed in immature hematopoietic cells. (PubMed id 8761303)9 Sakano S....Suda T. (Oncogene 1996)
    161. G1 cyclin degradation: the PEST motif of yeast Cln2 is necessary, but not sufficient, for rapid protein turnover. (PubMed id 7969135)9 Salama S.R....Thorner J. (Mol. Cell. Biol. 1994)
    162. Kinase selectivity potential for inhibitors targeting the ATP binding site: a network analysis. (PubMed id 19942586)9 Huang D....Caflisch A. (Bioinformatics 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2050 HGNC: 3395 AceView: EPHB4 Ensembl:ENSG00000196411 euGenes: HUgn2050
    ECgene: EPHB4 Kegg: 2050 H-InvDB: EPHB4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for EPHB4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EPHB4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for EPHB4 gene:
    Search GeneIP for patents involving EPHB4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of EPHB4
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Purified and/or Recombinant EPHB4 Protein
     
     EMD Millipore genomic analysis products

      
     Antibodies for EPHB4 (EphB4)   Browse Cell Culture Products  
     ELISAs for EPHB4 (EphB4)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for EPHB4 (EphB4)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for EPHB4 (EphB4)  
     OriGene Antibodies for EPHB4   OriGene RNAi products in human, mouse, rat for EPHB4  
     OriGene qPCR primer pairs and template standards for EPHB4   OriGene Protein Over-expression Lysate for EPHB4  
     OriGene MassSpec something-or-other for EPHB4   OriGene clones in human, mouse for EPHB4  
     OriGene qSTAR qPCR primer pairs in human, mouse for EPHB4   OriGene Purified Protein for EPHB4  
     OriGene ORF clones in mouse, rat for EPHB4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for EPHB4   OriGene Custom Protein Services for EPHB4  

     
     
     Block miRNA regulation of human, mouse, rat EPHB4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing EPHB4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EPHB4 Predesigned siRNA for gene silencing in human, mouse, rat EPHB4
     QuantiFast Probe-based Assays in human, mouse, rat EPHB4 QuantiTect SYBR Green Assays in human, mouse, rat EPHB4
     PCR Arrays including human, mouse, rat EPHB4 Search Chromatin IP Primers for EPHB4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EPHB4  GeneGlobe Interaction Network for EPHB4
     Regulatory tfbs in EPHB4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for EPHB4 GenScript cDNA clones with any tag delivered in your preferred vector for EPHB4
     GenScript EPHB4-Activity-based Kinase Assay for Compound Screening GenScript Custom overexpressing Cell Line Services for EPHB4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for EPHB4
     Browse Sino Biological Proteins
     Cell Lysates for EPHB4
     cDNA Clones for EPHB4
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for EPHB4
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     EPHB4 antibodies
     EPHB4 proteins
     EPHB4 lysates
     Antibodies for EPHB4
     See all of Abcam's Antibodies, Kits and Proteins for EPHB4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for EPHB4
     Antibodies for EPHB4
     ELISAs for EPHB4
     CLIAs for EPHB4



     Browse ESI BIO Cell Lines and PureStem Progenitors for EPHB4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHB4
     SwitchGear 3'UTR luciferase reporter plasmids for EPHB4
     SwitchGear Promoter luciferase reporter plasmids for EPHB4
     ThermoFisher Antibodies for EPHB4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHB4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EPHB4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EPHB4
     LSBio Antibodies in human, mouse, rat for EPHB4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for EPHB4
      Search eBioscience for proteins for EPHB4
      Search eBioscience for elisas for EPHB4
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      EPHB4 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4