EPHB4 Gene

Aliases
for EPHB4 gene

Previous GC identifers: GC07M098934 GC07M099997 GC07M100011 GC07M100044 GC07M100238 GC07M095030

Summaries
for EPHB4 gene

Genomic Views
for EPHB4 gene

RefSeq DNA sequence:

NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  

SwitchGear Promoter luciferase reporter plasmid: EPHB4 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPHB4

EPHB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M100402:  view genomic region     (about GC identifiers)

Proteins
for EPHB4 gene

6/15 PDB 3D structures from and Proteopedia for EPHB4 (see all 15):

2BBA (3D)        2E7H (3D)        2HLE (3D)        2QKQ (3D)        2VWU (3D)        2VWV (3D)    

Explore the universe of human proteins at neXtProt for EPHB4: NX_P54760

Post-translational modifications:

	EMD Millipore Purified and/or Recombinant EPHB4 Protein
	R&D Systems Recombinant & Natural Proteins for EPHB4
	Enzo Life Sciences proteins for EPHB4
	OriGene Purified Protein: EPHB4 OriGene Protein Over-expression Lysate: EPHB4 OriGene Custom Protein Services for EPHB4
	GenScript Custom Purified and Recombinant Proteins Services for EPHB4
	Novus Biologicals EPHB4 Proteins Novus Biologicals EPHB4 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for EPHB4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for EPHB4
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	GenScript Superior Antibodies for EPHB4
	Novus Biologicals EPHB4 Antibodies
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	Uscn Antibodies for EPHB4
	ThermoFisher Antibodies for EPHB4

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for EPHB4         (see all)
	GenScript Custom Assay Services for EPHB4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for EPHB4

Protein Domains /
Families
for EPHB4 gene

ProtoNet protein and cluster: P54760

Function
for EPHB4 gene

miRNA Products:		OriGene 3'-UTR Clone: EPHB4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EPHB4
		8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate EPHB4 (see all 39):
		hsa-miR-300 hsa-miR-106a hsa-miR-3653 hsa-miR-624 hsa-miR-301a hsa-miR-519a hsa-miR-124 hsa-miR-9
		SwitchGear 3'UTR luciferase reporter plasmid: EPHB4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EPHB4 (see all 4) OriGene shRNA RFP: EPHB4 OriGene siRNA: EPHB4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPHB4

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for EPHB4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EPHB4 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EPHB4 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: EPHB4 (NM_004444)
		Sino Biological Human cDNA Clone for EPHB4
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHB4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHB4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for EPHB4
		Search LifeMap BioReagents cell lines for EPHB4

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHB4

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Ephb4)

Pathways & Interactions
for EPHB4 gene

	Super-pathway	contained gene-specific pathways
1	GPCR Pathway	GPCR Pathway 1.00 Estrogen Pathway 0.55 Ras Pathway 0.62 Pancreatic Adenocarcinoma 0.55 Breast Cancer Regulation by Stathmin1 0.58 Paxillin Interactions 0.53 NFAT in Immune Response 0.58 P2Y Receptor Signaling 0.38
2	Rho Family GTPases	Rho Family GTPases 1.00 MAPK Signaling 0.51 ERK Signaling 0.61 ILK Signaling 0.45 Molecular Mechanisms of Cancer 0.51
3	Nanog in Mammalian ESC Pluripotency	Nanog in Mammalian ESC Pluripotency 1.00 14-3-3 Induced Intracellular Signaling 0.59 GSK3 Signaling 0.61 eNOS Signaling 0.48
4	Actin Nucleation by ARP-WASP Complex	Actin Nucleation by ARP-WASP Complex 1.00 CDC42 Pathway 0.34 Actin Nucleation and Branching 0.66
5	Cell adhesion_Ephrins signaling	Cell adhesion_Ephrins signaling 1.00 EPHB forward signaling 0.30 Cell adhesion Ephrins signaling 1.00

2 EMD Millipore Pathways for EPHB4

	Cytoskeleton remodeling Reverse signaling by ephrin B
	Cell adhesion Ephrins signaling

5/31 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EPHB4

	MAPK Signaling
	Paxillin Interactions
	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Ephrin-Eph Signaling

2 GeneGo (Thomson Reuters) Pathways for EPHB4

	Cytoskeleton remodeling Reverse signaling by ephrin B
	Cell adhesion Ephrins signaling

3 BioSystems Pathways for EPHB4

	Ephrin B reverse signaling
	EPHB forward signaling
	EphrinB-EPHB pathway

1         Kegg Pathway  (Kegg details for EPHB4)

Axon guidance

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

Drugs & Compounds
for EPHB4 gene

Transcripts
for EPHB4 gene

Expression
for EPHB4 gene

EPHB4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTGTTTCCA

4 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	HeartCardinal VeinsVenous Endothelial Cells			Endothelium
	LungPulmonary Capillary PlexusVenous Endothelial Cells			Endothelium
	Lateral Plate MesodermEmbryonic Capillary PlexusAngioblasts			Endothelium
	LungPulmonary Capillary PlexusAngioblasts			Endothelium
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 5 LifeMap Cells
	Name			Category
	PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)			Blood, Endothelium
	PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)			Blood, Endothelium
	PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)			Endothelium
	Endothelial-like cells (Generation of hemato...)
	Endothelial-like cells (Derivation and purif...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EPHB4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EPHB4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPHB4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPHB4

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHB4

Orthologs
for EPHB4 gene

Paralogs
for EPHB4 gene

Paralogs for EPHB4 gene

EPHB1²  EPHA2²  EPHB3²  EPHA4²  EPHA5²  EPHB6²  EPHA6²  EPHB2²  

EPHA1²  EPHA8²  EPHA3²  EPHA7²  EPHA10²  

18/23 SIMAP similar genes for EPHB4 using alignment to 7 protein entries:     EPHB4_HUMAN (see all proteins) (see all similar genes):

EPHB3    EPHB1    EPHB2 variant protein    EPHA2    EPHA3    EPHA4

EPHA7    EPHB2    EPHA6    EPHA8    FRK    EPHA5

HCK    YES1    EPHA10    EPHB6    LCK    LYN

EPHB4 for paralogs           About GeneDecksing

Genomic Variants
for EPHB4 gene

10/553 NCBI SNPs in EPHB4 are shown (see all 553)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1149419421,2	C,	--	100399695(+)	CACACA/GTGGGG	1	--	ds5001		0	--	--	--	--
rs746262601,2	C,F,	--	100399697(+)	CACGTG/TGGGGG	1	--	ds5001		1		WA	118
rs117732811,2	H	--	100399704(+)	GGGGGG/TCCCTT	1	--	ds5001		0	--	--	--	--
rs559822651,2	C,F,	--	100399802(+)	TCCATC/TCACGG	1	--	ds5001		3		WA NA EA	358
rs1489635661,2		--	100399805(+)	ATCCAC/TGGAAC	1	--	ds5001		0	--	--	--	--
rs1909626041,2		--	100400105(+)	TCCAGA/CCCTCT	1	--	ds5001		0	--	--	--	--
rs559455031,2	C,	--	100400124(+)	TCGGTC/AAGCCA	1	--	ds5001		5		WA CSA NA EA	362
rs1823823421,2		--	100400277(+)	ACCGGC/TGTCCG	1	--	ut31		0	--	--	--	--
rs1877509731,2		--	100400294(+)	GGTTCC/TACCAC	1	--	ut31		0	--	--	--	--
rs1436431191,2		--	100400297(+)	TCCACC/TACCAA	1	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for EPHB4 (100400187 - 100425143 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for EPHB4
     1 CNV: 3692

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EPHB4

DNA2.0 Custom Variant and Variant Library Synthesis for EPHB4

Disorders / Diseases
for EPHB4 gene

20/47 diseases for EPHB4

10/22 Novoseek disease relationships for EPHB4 gene (see all 22)    About this table

Publications
for EPHB4 gene

PubMed articles for EPHB4 gene, integrated from 9 sources (see all 163) (see top 10): (articles sorted by number of sources associating them with EPHB4)

Utopia: connect your pdf to the dynamic world of online information

1. Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily. (PubMed id 8188704)^{1, 2, 3, 9} Bennett B.D.... Scadden D.T. (1994)
2. Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells. (PubMed id 12734395)^{1, 2, 9} Fuller T....Augustin H.G. (2003)
3. Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity. (PubMed id 16867992)^{1, 2, 9} Chrencik J.E....Kuhn P. (2006)
4. EphB4 controls blood vascular morphogenesis during postnatal angiogenesis. (PubMed id 16424904)^{1, 2, 9} Erber R....Vajkoczy P. (2006)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
6. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. (PubMed id 11239002)^{1, 2} Wilson M.D....Koop B.F. (2001)
7. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PubMed id 9267020)^{1, 2} (1997)
8. Receptor tyrosine kinase, EphB4 (HTK), accelerates differentiation of select human hematopoietic cells. (PubMed id 11929761)^{1, 9} Wang Z....Scadden D.T. (2002)
9. EphB4 expression and biological significance in prostate cancer. (PubMed id 15930280)^{1, 9} Xia G....Gill P.S. (2005)
10. The receptor tyrosine kinase EphB4 is overexpressed in ovarian cancer, provides survival signals and predicts poor outcome. (PubMed id 17353927)^{1, 9} Kumar S.R....Gill P.S. (2007)
11. Coexpression of EphB4 and ephrinB2 in tumor advanceme nt of uterine cervical cancers. (PubMed id 19356789)^{1, 9} Alam S.M....Tamaya T. (2009)
12. Ephrin-independent regulation of cell substrate adhes ion by the EphB4 receptor. (PubMed id 19552627)^{1, 9} Noren N.K....Pasquale E.B. (2009)
13. Coexpression of EphB4 and ephrinB2 in tumour advancement of ovarian cancers. (PubMed id 18231102)^{1, 9} Alam S.M....Tamaya T. (2008)
14. EphB4 provides survival advantage to squamous cell carcinoma of the head and neck. (PubMed id 16615113)^{1, 9} Masood R....Gill P.S. (2006)
15. Novel EphB4 monoclonal antibodies modulate angiogenes is and inhibit tumor growth. (PubMed id 20133814)^{1, 9} Krasnoperov V....Gill P.S. (2010)
16. Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression. (PubMed id 19366806)^{1, 9} Kumar S.R....Gill P.S. (2009)
17. PSGL-1-mediated activation of EphB4 increases the proangiogenic potential of endothelial progenitor cells. (PubMed id 17510705)^{1, 9} Foubert P....Le Ricousse-Roussanne S. (2007)
18. Cell adhesion to ephrinb2 is induced by EphB4 independently of its kinase activity. (PubMed id 15358160)^{1, 9} Sakamoto H....Suda T. (2004)
19. Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leuk emia. (PubMed id 20061560)^{1, 9} Kuang S.Q....Garcia-Manero G. (2010)
20. BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell li ne with activation of EphB4. (PubMed id 20002159)^{1, 9} Suzuki M....Naoe T. (2010)
21. The ephrinB2/EphB4 axis is dysregulated in osteoproge nitors from myeloma patients and its activation affects myeloma bone disease an d tumor growth. (PubMed id 19597185)^{1, 9} Pennisi A....Yaccoby S. (2009)
22. Investigation of the expression of the EphB4 receptor tyrosine kinase in prostate carcinoma. (PubMed id 16171530)^{1, 9} Lee Y.C....Stephenson S.A. (2005)
23. Homeobox A9 transcriptionally regulates the EphB4 receptor to modulate endothelial cell migration and tube formation. (PubMed id 14764452)^{1, 9} Bruhl T....Dimmeler S. (2004)
24. Expression and prognostic significance of EFNB2 and EphB4 genes in patients with oesophageal squamous cell carcinoma. (PubMed id 17611172)^{1, 9} Tachibana M....Yoshimura H. (2007)
25. EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodeling. (PubMed id 16840724)^{1, 9} Salvucci O....Tosato G. (2006)
26. Differential expression of the receptor tyrosine kinase EphB4 and its ligand Ephrin-B2 during human placental development. (PubMed id 16343615)^{1, 9} Chennakesava C.S....Andres A.C. (2006)
27. Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity. (PubMed id 16472751)^{2, 9} Chrencik J.E....Kuhn P. (2006)
28. Syndecan-1 up-regulated by ephrinB2/EphB4 plays dual roles in inflammatory angiogenesis. (PubMed id 15126321)^{1, 9} Yuan K....Lin M.T. (2004)
29. Expression of the receptor protein tyrosine kinase myk-1/htk in normal and malignant mammary epithelium. (PubMed id 8831703)^{1, 9} Berclaz G....Crompton M.R. (1996)
30. Treatment with ephrin B2 positively impacts the abnor mal metabolism of human osteoarthritic chondrocytes. (PubMed id 19664212)^{1, 9} Kwan Tat S....Martel-Pelletier J. (2009)
31. Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts. (PubMed id 19035475)^{1, 9} Kwan Tat S....Martel-Pelletier J. (2008)
32. Notch ligand Delta-like 1 is essential for postnatal arteriogenesis. (PubMed id 17234965)^{1, 9} Limbourg A....Limbourg F.P. (2007)
33. Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the phosphatidylinositol 3-kinase pathway. (PubMed id 12235151)^{1, 9} Steinle J.J....Granger H.J. (2002)
34. Coexpression of ephrin-Bs and their receptors in colon carcinoma. (PubMed id 11920461)^{1, 9} Liu W....Ellis L.M. (2002)
35. Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. (PubMed id 10518221)^{1, 9} Gerety S.S....Anderson D.J. (1999)
36. EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity. (PubMed id 15722342)^{1, 9} Koolpe M....Pasquale E.B. (2005)
37. Eph and ephrin expression in normal placental development and preeclampsia. (PubMed id 15193868)^{1, 9} Goldman-Wohl D....Yagel S. (2004)
38. EphB4 is overexpressed in papillary thyroid carcinoma and promotes the migration of papillary thyroid cancer cells. (PubMed id 22528941)¹ Xuqing W....Jianxin Z. (2012)
39. Relationships among differentiation degree, contrast-e nhanced ultrasound and the expression of Ephb4/Ephrinb2 in primary hepatocarcino ma. (PubMed id 22024229)¹ Zhu X.L....Zhang N. (2012)
40. Expression of EphrinB2 and EphB4 in glioma tissues cor related to the progression of glioma and the prognosis of glioblastoma patients. (PubMed id 22374425)¹ Tu Y....Deng J. (2012)
41. EphB4 gene polymorphism and protein expression in non- small-cell lung cancer. (PubMed id 22684742)¹ Zheng M.F....Chen J.Y. (2012)
42. Eph/ephrin profiling in human breast cancer reveals si gnificant associations between expression level and clinical outcome. (PubMed id 21935409)¹ Brantley-Sieders D.M....Chen J. (2011)
43. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
44. [Relationship between multi-slice spiral CT pulmonary perfusion imaging and the expression of EphB4 and ephrinB2 in non-small cell lun g cancer]. (PubMed id 21575518)¹ Xiong Z....Chen W. (2011)
45. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
46. Distribution of EphB4 and EphrinB2 in normal and mali gnant urogenital tissue. (PubMed id 19272799)¹ OzgA1r E....Bloch W. (2011)
47. Over-expression of Ephb4 is associated with carcinoge nesis of gastric cancer. (PubMed id 20686847)¹ Li M....Xin Y. (2011)
48. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
49. The EphB6 receptor cooperates with c-Cbl to regulate the behavior of breast cancer cells. (PubMed id 20086179)¹ Truitt L....Freywald A. (2010)
50. EphB4 promotes site-specific metastatic tumor cell di ssemination by interacting with endothelial cell-expressed ephrinB2. (PubMed id 21047731)¹ HAcroult M....Augustin H.G. (2010)
51. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
52. EPHB4 gene polymorphisms and risk of intracranial hem orrhage in patients with brain arteriovenous malformations. (PubMed id 20031623)¹ Weinsheimer S....Young W.L. (2009)
53. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)² Oppermann F.S.... Daub H. (2009)
54. Involvement of endothelial ephrin-B2 in adhesion and transmigration of EphB-receptor-expressing monocytes. (PubMed id 18957513)¹ Pfaff D....Augustin H.G. (2008)
55. Cytochrome P450 2C9-induced angiogenesis is dependent on EphB4. (PubMed id 18340006)¹ Webler A.C....Fleming I. (2008)
56. Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. (PubMed id 18593464)¹ Jin P.... Paleolog E.M. (2008)
57. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)² Daub H.... Mann M. (2008)
58. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
59. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)² Greenman C.... Stratton M.R. (2007)
60. Expression of Eph B4 and Ephrin B2 in cervical cancer tissues and angiogenesis. (PubMed id 17196593)¹ Zhang S....Liang M. (2007)
61. EPHB4 and survival of colorectal cancer patients. (PubMed id 16982731)¹ Davalos V....Arango D. (2006)
62. The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth. (PubMed id 16322467)¹ Kertesz N....Gill P.S. (2006)
63. EphB4 receptor tyrosine kinase is expressed in bladder cancer and provides signals for cell survival. (PubMed id 16205642)¹ Xia G....Gill P.S. (2006)
64. EPHB4 regulates chemokine-evoked trophoblast responses: a mechanism for incorporating the human placenta into the maternal circulation. (PubMed id 16107476)¹ Red-Horse K....Fisher S.J. (2005)
65. Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. (PubMed id 15951569)¹ Zhang Y.... White F.M. (2005)
66. Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. (PubMed id 12493773)¹ Shin B.K....Hanash S.M. (2003)
67. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)¹ Scherer S.W.... Tsui L.-C. (2003)
68. A role of EphB4 receptor and its ligand, ephrin-B2, in erythropoiesis. (PubMed id 12051776)¹ Suenobu S....Suda T. (2002)
69. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
70. Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells. (PubMed id 11466354)¹ Luo H....Wu J. (2001)
71. Multiple roles of EPH receptors and ephrins in neural development. (PubMed id 11256076)¹ Wilkinson D.G. (2001)
72. Roles of Eph receptors and ephrins in segmental patterning. (PubMed id 11128993)¹ Xu Q....Wilkinson D.G. (2000)
73. Eph receptors and ephrins: regulators of guidance and assembly. (PubMed id 10730216)¹ Wilkinson D.G. (2000)
74. EphB receptors interact with NMDA receptors and regulate excitatory synapse formation. (PubMed id 11136979)¹ Dalva M.B....Greenberg M.E. (2000)
75. The Protein Data Bank. (PubMed id 10592235)⁷ Berman H.M....Bourne P.E. (2000)
76. Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma. (PubMed id 10037197)¹ Tang X.X....Ikegaki N. (1999)
77. Eph receptors and ephrins: effectors of morphogenesis. (PubMed id 10207129)¹ Holder N. and Klein R. (1999)
78. Cell-type specific and estrogen dependent expression of the receptor tyrosine kinase EphB4 and its ligand ephrin-B2 during mammary gland morphogenesis. (PubMed id 9718367)¹ Nikolova Z....Ziemiecki A. (1998)
79. The Eph family receptors and ligands. (PubMed id 9576626)¹ Zhou R. (1998)
80. The ephrins and Eph receptors in neural development. (PubMed id 9530499)¹ Flanagan J.G. and Vanderhaeghen P. (1998)
81. Phosphorylation of recombinant N-syndecan (syndecan 3) core protein. (PubMed id 9388509)¹ Asundi V.K. and Carey D.J. (1997)
82. Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis. (PubMed id 8152808)¹ Andres A.C....Ziemiecki A. (1994)
83. Overexpression of ephrinB2 and EphB4 in tumor advancement of uterine endometrial cancers. (PubMed id 17108150)⁹ Alam S.M....Tamaya T. (2007)
84. The association between elevated EphB4 expression, smoking status, and advanced-stage disease in patients with head and neck squamous cell carcinoma. (PubMed id 17043250)⁹ Sinha U.K....Gill P.S. (2006)
85. The significance of EphB4 and EphrinB2 expression and survival in head and neck squamous cell carcinoma. (PubMed id 18794445)⁹ Yavrouian E.J....Masood R. (2008)
86. Expression of receptor tyrosine kinase HTK (hepatoma transmembrane kinase) and HTK ligand by human leukemia-lymphoma cell lines. (PubMed id 10221518)⁹ Steube K.G....Drexler H.G. (1999)
87. Soluble EphB4 inhibition of PDGF-induced RPE migratio n in vitro. (PubMed id 19696168)⁹ He S....Hinton D.R. (2010)
88. NF-Y-mediated trans-activation of the human thymidine kinase promoter is closely linked to activation of cyclin-dependent kinase. (PubMed id 10502302)⁹ Chang Z.F....Hu S.F. (1999)
89. Ephrin B2/EphB4 pathway in hepatic stellate cells sti mulates Erk-dependent VEGF production and sinusoidal endothelial cell recruitme nt. (PubMed id 20338920)⁹ Das A....Shah V.H. (2010)
90. Expression of Ephb2 and Ephb4 in breast carcinoma. (PubMed id 15029258)⁹ Wu Q....Nesland J.M. (2004)
91. Degradation of human thymidine kinase is dependent on serine-13 phosphorylation: involvement of the SCF-mediated pathway. (PubMed id 12435275)⁹ Ke P.Y....Chang Z.F. (2003)
92. Different regulation of the human thymidine kinase promoter in normal human diploid IMR-90 fibroblasts and HeLa cells. (PubMed id 7593001)⁹ Chang Z.F....Lai T.C. (1995)
93. Receptor tyrosine kinase EphB4 is a survival factor in breast cancer. (PubMed id 16816380)⁹ Kumar S.R....Gill P.S. (2006)
94. EphB4 signaling is capable of mediating ephrinB2-induced inhibition of cell migration. (PubMed id 14672701)⁹ Sturz A....Glienke J. (2004)
95. Expression of EphB4 in head and neck squamous cell carcinoma. (PubMed id 14661437)⁹ Sinha U.K....Gill P.S. (2003)
96. Activation of the receptor protein tyrosine kinase EphB4 in endometrial hyperplasia and endometrial carcinoma. (PubMed id 12562648)⁹ Berclaz G....Andres A.C. (2003)
97. Loss of EphB4 receptor tyrosine kinase protein expression during carcinogenesis of the human breast. (PubMed id 12168060)⁹ Berclaz G....Andres A.C. (2002)
98. EphrinB2 and EphB4 expression in pterygia: new insigh ts and preliminary results. (PubMed id 19491953)⁹ Xue C....Zhou X. (2009)
99. Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design. (PubMed id 17062140)⁹ El Omari K....Stammers D.K. (2006)
100. Soluble forms of EphrinB2 and EphB4 reduce retinal neovascularization in a model of proliferative retinopathy. (PubMed id 15914639)⁹ Zamora D.O....Powers M.R. (2005)
101. Expression of Tie-2, angiopoietin-1, angiopoietin-2, ephrinB2 and EphB4 in pyogenic granuloma of human gingiva implicates their roles in inflammatory angiogenesis. (PubMed id 10929871)⁹ Yuan K....Lin M.T. (2000)
102. Altered vascular expression of EphrinB2 and EphB4 in a model of oxygen-induced retinopathy. (PubMed id 20503366)⁹ Davies M.H....Powers M.R. (2010)
103. Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4). (PubMed id 19788238)⁹ Lafleur K....Nevado C. (2009)
104. Ephrin B2 expression in Kaposi sarcoma is induced by human herpesvirus type 8: phenotype switch from venous to arterial endothelium. (PubMed id 15471957)⁹ Masood R....Gill P.S. (2005)
105. Kinase recognition by calmodulin: modeling the interaction with the autoinhibitory region of human cardiac titin kinase. (PubMed id 11178895)⁹ Amodeo P....Motta A. (2001)
106. Stromal cells expressing ephrin-B2 promote the growth and sprouting of ephrin-B2(+) endothelial cells. (PubMed id 11493448)⁹ Zhang X.Q....Suda T. (2001)
107. Communication Between EphrinB2 and EphB4 Within the O steoblast Lineage. (PubMed id 19950015)⁹ Martin T.J....Sims N.A. (2010)
108. Altered expression patterns of EphrinB2 and EphB2 in human umbilical vessels and congenital venous malformations. (PubMed id 15718372)⁹ Diehl S....Klein R. (2005)
109. Akt/protein kinase B and endothelial nitric oxide synthase mediate muscular neovascularization induced by tissue kallikrein gene transfer. (PubMed id 15364809)⁹ Emanueli C....Madeddu P. (2004)
110. Ephrin receptor, EphB4, regulates ES cell differentiation of primitive mammalian hemangioblasts, blood, cardiomyocytes, and blood vessels. (PubMed id 12958066)⁹ Wang Z....Scadden D.T. (2004)
111. Inhibition of tumor growth and angiogenesis by soluble EphB4. (PubMed id 15153337)⁹ Martiny-Baron G....Augustin H.G. (2004)
112. Distinct roles of ephrin-B2 forward and EphB4 reverse signaling in endothelial cells. (PubMed id 12588758)⁹ Hamada K....Suda T. (2003)
113. Prevention of diabetes-induced microangiopathy by human tissue kallikrein gene transfer. (PubMed id 12186806)⁹ Emanueli C....Madeddu P. (2002)
114. Expression of receptor tyrosine kinase EphB4 and its ligand ephrin-B2 is associated with malignant potential in endometrial cancer. (PubMed id 11295082)⁹ Takai N....Miyakawa I. (2001)
115. Type-2 diabetic Lepr(db/db) mice show a defective microvascular phenotype under basal conditions and an impaired response to angiogenesis gene therapy in the setting of limb ischemia. (PubMed id 17127438)⁹ Emanueli C....Madeddu P. (2007)
116. Regional and global protective effects of tissue kallikrein gene delivery to the peri-infarct myocardium. (PubMed id 17465807)⁹ Spillmann F....Madeddu P. (2006)
117. [Detecting protein expression of EphrinB2 ligand and its receptor EphB4 in astrocytoma using confocal laser scanning microscopy] (PubMed id 15473927)⁹ Xiao H.L....Wang D. (2004)
118. Optimisation of the RT-PCR detection of immunomagnetically enriched carcinoma cells. (PubMed id 12031094)⁹ Raynor M....Dobrovic A. (2002)
119. Eph and ephrin interactions in bone. (PubMed id 19950019)⁹ Matsuo K. (2010)
120. Fluid shear stress induces arterial differentiation of endothelial progenitor cells. (PubMed id 18988767)⁹ Obi S....Ando J. (2009)
121. Imidazo[1,2-a]pyrazine diaryl ureas: inhibitors of th e receptor tyrosine kinase EphB4. (PubMed id 19879134)⁹ Mitchell S.A....Elkin L.L. (2009)
122. [Mesh structure of two-dimensional tumor microvascula r architecture phenotype heterogeneity in non-small cell lung cancer] (PubMed id 19923070)⁹ Xiong Z....Zhou J.H. (2009)
123. The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade. (PubMed id 18836096)⁹ Scehnet J.S....Gill P.S. (2009)
124. Crystal structure and NMR binding reveal that two small molecule antagonists target the high affinity ephrin-binding channel of the EphA4 receptor. (PubMed id 18708347)⁹ Qin H....Song J. (2008)
125. Discovery of kinase inhibitors by high-throughput docking and scoring based on a transferable linear interaction energy model. (PubMed id 18271520)⁹ Kolb P....Caflisch A. (2008)
126. Brothers and sisters: molecular insights into arterial-venous heterogeneity. (PubMed id 18948631)⁹ Aitsebaomo J....Patterson C. (2008)
127. The EPH receptor Bs (EPHBs) promoters are unmethylated in colon and ovarian cancers. (PubMed id 18281782)⁹ Wu Q....Suo Z. (2007)
128. Framework shuffling of antibodies to reduce immunogenicity and manipulate functional and biophysical properties. (PubMed id 17241664)⁹ Damschroder M.M....Wu H. (2007)
129. Paradoxes of the EphB4 receptor in cancer. (PubMed id 17483308)⁹ Noren N.K. and Pasquale E.B. (2007)
130. Expression of ephrin in retinal neovascularization and iris rubeosis. (PubMed id 17133777)⁹ Yuuki T....Kishi S. (2006)
131. Human leukocytes express ephrinB2 which activates microvascular endothelial cells. (PubMed id 17123494)⁹ Zamora D.O....Rosenbaum J.T. (2006)
132. Putative dual role of ephrin-Eph receptor interactions in inflammation. (PubMed id 16801213)⁹ Ivanov A.I. and Romanovsky A.A. (2006)
133. The prognostic impact of EphB2/B4 expression on patients with advanced ovarian carcinoma. (PubMed id 16499955)⁹ Wu Q....Nesland J.M. (2006)
134. New potential ligand-receptor signaling loops in ovarian cancer identified in multiple gene expression studies. (PubMed id 17090524)⁹ Castellano G....Canevari S. (2006)
135. Dll4-selective Notch signaling induces ephrinB2 gene expression in endothelial cells. (PubMed id 16430858)⁹ Iso T....Kurabayashi M. (2006)
136. Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells. (PubMed id 15657067)⁹ Thelemann A....Haley J.D. (2005)
137. Down-regulation of endothelial ephrinB2 expression by laminar shear stress. (PubMed id 15763946)⁹ Goettsch W....Morawietz H. (2004)
138. The relationship between oncogene expression and clinical outcome in endometrial carcinoma. (PubMed id 15379636)⁹ Takai N....Miyakawa I. (2004)
139. Expression of ephrinB2 and its receptors on fibroproliferative membranes in ocular angiogenic diseases. (PubMed id 15289137)⁹ Umeda N....Oshima K. (2004)
140. Inhibitory and enhancing effects of insertion of central polypurine tract sequence on gene expression with vectors derived from human immunodeficiency virus type 1. (PubMed id 12615060)⁹ Sakuma R....Kitamura Y. (2003)
141. Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung. (PubMed id 12842817)⁹ Favre C.J....McDonald D.M. (2003)
142. Regulation of thymidine kinase expression during cellular senescence. (PubMed id 11287748)⁹ Chang Z.F. and Huang D.Y. (2001)
143. Receptor protein tyrosine kinase EphB4 is up-regulated in colon cancer. (PubMed id 11801186)⁹ Stephenson S.A....Hardingham J.E. (2001)
144. Regulation of the activity and polymerization status of recombinant human cytosolic thymidine kinase by thiols and ATP. (PubMed id 10639574)⁹ Kuroiwa N....Fujimura S. (2000)
145. The bystander effect in the HSVtk/ganciclovir system and its relationship to gap junctional communication. (PubMed id 10023450)⁹ Touraine R.L....Blaese R.M. (1998)
146. Characterization of a ligand for receptor protein-tyrosine kinase HTK expressed in immature hematopoietic cells. (PubMed id 8761303)⁹ Sakano S....Suda T. (1996)
147. G1 cyclin degradation: the PEST motif of yeast Cln2 is necessary, but not sufficient, for rapid protein turnover. (PubMed id 7969135)⁹ Salama S.R....Thorner J. (1994)
148. Kinase selectivity potential for inhibitors targeting the ATP binding site: a network analysis. (PubMed id 19942586)⁹ Huang D....Caflisch A. (2010)
149. ADAM9 as a potential target molecule in cancer. (PubMed id 19601830)⁹ Peduto L. (2009)
150. [Significance and mechanism of MSCT perfusion scan on differentiation of NSCLC] (PubMed id 19950560)⁹ Liu J.K....Chen W. (2009)
151. Soluble ephrin-B2 mediates apoptosis in retinal neovascularization and in endothelial cells. (PubMed id 19232363)⁹ Davies M.H....Powers M.R. (2009)
152. Long term survival following the detection of circula ting tumour cells in head and neck squamous cell carcinoma. (PubMed id 19961621)⁹ Winter S.C....Rees G. (2009)
153. Inhibitors of the tyrosine kinase EphB4. Part 2: stru cture-based discovery and optimisation of 3,5-bis substituted anilinopyrimidine s. (PubMed id 18851911)⁹ Bardelle C....Williams E.J. (2008)
154. Osteoclast-osteoblast communication. (PubMed id 18406338)⁹ Matsuo K. and Irie N. (2008)
155. Up-regulation of EphB and ephrin-B expression in rhabdomyosarcoma. (PubMed id 18507018)⁹ Berardi A.C....Dominici C. (2008)
156. Structure-based tailoring of compound libraries for high-throughput screening: discovery of novel EphB4 kinase inhibitors. (PubMed id 18384152)⁹ Kolb P....Caflisch A. (2008)
157. Metabolism and pharmacokinetics of a novel Src kinase inhibitor TG100435 ([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4- (2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and its active N-oxide metabolite TG100855 ([7-(2,6-dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[ 2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine). (PubMed id 17371799)⁹ Hu S.X....Martin M. (2007)
158. The histone methyltransferase MLL is an upstream regulator of endothelial-cell sprout formation. (PubMed id 17047146)⁹ Diehl F....Urbich C. (2007)
159. Ena/VASP proteins mediate repulsion from ephrin ligands. (PubMed id 17179204)⁹ Evans I.R....Nobes C.D. (2007)
160. Growth factor receptors in hematopoietic stem cells: EPH family expression in CD34+ and CD133+ cell populations from mobilized peripheral blood. (PubMed id 16569339)⁹ Lazarova P....Nesland J.M. (2006)
161. Comparative integromics on Eph family. (PubMed id 16596241)⁹ Katoh M. and Katoh M. (2006)
162. EphB4 receptor tyrosine kinase transgenic mice develo p glomerulopathies reminiscent of aglomerular vascular shunts. (PubMed id 12676328)⁹ Andres A.C....Ziemiecki A. (2003)

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