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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EPHB4 Gene

protein-coding   GIFtS: 72
GCID: GC07M100402

EPH Receptor B4

(Previous name: EphB4)
(Previous symbol: HTK)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
EPH Receptor B41 2     Ephrin Receptor EphB42
HTK1 2 3 5     Ephrin Type-B Receptor 42
MYK12 3 5     Soluble EPHB4 Variant 12
Hepatoma Transmembrane Kinase2 3     Soluble EPHB4 Variant 22
Tyrosine-Protein Kinase TYRO112 3     Soluble EPHB4 Variant 32
TYRO112 3     Tyrosine-Protein Kinase Receptor HTK2
EC 2.7.10.13 8     EC 2.7.108
EphB41     

External Ids:    HGNC: 33951   Entrez Gene: 20502   Ensembl: ENSG000001964117   OMIM: 6000115   UniProtKB: P547603   

Export aliases for EPHB4 gene to outside databases

Previous GC identifers: GC07M098934 GC07M099997 GC07M100011 GC07M100044 GC07M100238 GC07M095030


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EPHB4 Gene:
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the
nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A
(EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B
(EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on
the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B
ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein
encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. (provided by RefSeq,
Jul 2008)

GeneCards Summary for EPHB4 Gene: 
EPHB4 (EPH receptor B4) is a protein-coding gene. Diseases associated with EPHB4 include conjunctivitis, and pyogenic granuloma, and among its related super-pathways are Cell adhesion Ephrins signaling and Ras Pathway. GO annotations related to this gene include ephrin receptor activity and transmembrane receptor protein tyrosine kinase activity. An important paralog of this gene is EPHB1.

UniProtKB/Swiss-Prot: EPHB4_HUMAN, P54760
Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on
adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2
plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell
migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing
cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus
important in the context of tumor angiogenesis

summary for EPHB4 Gene:
Ephrins are a family of receptor tyrosine kinases (RTKs) that influence cell migration. In conjunction with
the ephrin ligands, ephrin receptors are involved in a variety of developmental events. EphB4 is
overexpressed in many tumor types, including breast and prostate cancer.

Gene Wiki entry for EPHB4 (EPH receptor B4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EPHB4 gene promoter:
         AP-2rep   AREB6   p53   AP-1   p300   Lmo2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEPHB4 promoter sequence
   Search SABiosciences Chromatin IP Primers for EPHB4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPHB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22

EPHB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHB4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M100402:  view genomic region     (about GC identifiers)

Start:
100,400,187 bp from pter      End:
100,425,143 bp from pter
Size:
24,957 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 99,759,792-99,784,748     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EPHB4_HUMAN, P54760 (See protein sequence)
Recommended Name: Ephrin type-B receptor 4 precursor  
Size: 987 amino acids; 108270 Da
Subunit: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a
receptor dimer. Oligomerization is probably required to induce biological responses (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein
Developmental stage: Expressed in fetal heart, lung, liver and to a lower extent in brain. Not expressed in adult
brain
6/16 PDB 3D structures from and Proteopedia for EPHB4 (see all 16):
2BBA (3D)        2E7H (3D)        2HLE (3D)        2QKQ (3D)        2VWU (3D)        2VWV (3D)    
Secondary accessions: Q9BTA5 Q9BXP0

Explore the universe of human proteins at neXtProt for EPHB4: NX_P54760

Explore proteomics data for EPHB4 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated; autophosphorylation is stimulated by EFNB2
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P54760

  • 4/25 DME Specific Peptides for EPHB4 (P54760) (see all 25)
     MSNQDVI  RDLAARN  SDPTYTS  QLMLDCW 

    EPHB4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EPHB4 Protein Expression
    REFSEQ proteins: NP_004435.3  
    ENSEMBL proteins: 
     ENSP00000353833   ENSP00000350896  

    Human Recombinant Protein Products for EPHB4: 
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    OriGene Protein Over-expression Lysate for EPHB4
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    Novus Biologicals EPHB4 Proteins
    Novus Biologicals EPHB4 Lysate
    Sino Biological Recombinant Protein for EPHB4
    Sino Biological Cell Lysate for EPHB4 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EPHB4 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane IDA8188704
    GO:0009986cell surface IDA12493773

    EPHB4 for ontologies           About GeneDecksing



    EPHB4 Antibody Products: 
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    Assay Products for EPHB4: 
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    Cloud-Clone Corp. ELISAs for EPHB4 
    Cloud-Clone Corp. CLIAs for EPHB4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FN3: Fibronectin type III domain containing
    EPH: EPH receptors
    SAMD: Sterile alpha motif (SAM) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: EPH receptor B4 
    Ephrin receptor family
    Ephrin receptor family

    5/16 InterPro protein domains (see all 16):
     IPR017441 Protein_kinase_ATP_BS
     IPR003961 Fibronectin_type3
     IPR021129 SAM_type1
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P54760

    ProtoNet protein and cluster: P54760

    5 Blocks protein domains:
    IPB001090 Ephrin receptor
    IPB001426 Receptor tyrosine kinase
    IPB001660 Sterile alpha motif SAM
    IPB003962 Fibronectin type III repeat signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EPHB4_HUMAN, P54760
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    EPHB4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EPHB4_HUMAN, P54760
    Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on
    adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
    pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
    the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2
    plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell
    migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing
    cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus
    important in the context of tumor angiogenesis
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for EPHB4:
    EPH-related tyrosine kinase receptor,binding ephrin B4,expressed in projecting neurons and their target
    fields,involved in short-range contact-mediated axonal guidance,also involved in angiogenesis by marking venous
    but not arterial endothelial cells

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity IDA8188704
    GO:0005003ephrin receptor activity IDA12734395
    GO:0005515protein binding IPI16867992
         
    EPHB4 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for EPHB4:
     Decreased focal adhesion (FA)   Increased cell death in HCT116  Increased colony dispersion (i 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ephb4):
     cardiovascular system  embryogenesis  growth/size  mortality/aging  muscle 

    EPHB4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for EPHB4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EPHB4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EPHB4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EPHB4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EPHB4
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate EPHB4 (see all 39):
    hsa-miR-300 hsa-miR-106a hsa-miR-3653 hsa-miR-624 hsa-miR-301a hsa-miR-519a hsa-miR-124 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidEPHB4 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: EPHB4 (NM_004444)
    Sino Biological Human cDNA Clone for EPHB4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHB4
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                         Customized lentivirus expression plasmids for stable overexpression of EPHB4 

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHB4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EPHB4 About   (see all 16)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell adhesion Ephrins signaling
    Cell adhesion Ephrins signaling0.30
    EPHB forward signaling0.30
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    3Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    CDC42 Pathway0.41
    Actin Nucleation and Branching0.66

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for EPHB4
        Cytoskeleton remodeling Reverse signaling by ephrin B
    Cell adhesion Ephrins signaling

    5/31 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EPHB4 (see all 31)
        MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Ephrin-Eph Signaling

    2 GeneGo (Thomson Reuters) Pathways for EPHB4
        Cytoskeleton remodeling Reverse signaling by ephrin B
    Cell adhesion Ephrins signaling

    3 BioSystems Pathways for EPHB4
        Ephrin B reverse signaling
    EPHB forward signaling
    EphrinB-EPHB pathway



    1         Kegg Pathway  (Kegg details for EPHB4):
        Axon guidance


    EPHB4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EPHB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/15 Interacting proteins for EPHB4 (P547603 ENSP000003508964) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRIN1Q055863, ENSP000003606164I2D: score=2 STRING: ENSP00000360616
    SDC3O750563, ENSP000003444684I2D: score=2 STRING: ENSP00000344468
    EFNB2P527993, ENSP000002453234I2D: score=1 STRING: ENSP00000245323
    JUNP054123, ENSP000003602664I2D: score=1 STRING: ENSP00000360266
    EGFRP005333, ENSP000002754934I2D: score=1 STRING: ENSP00000275493
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis ISS--
    GO:0002042cell migration involved in sprouting angiogenesis IDA12734395
    GO:0003007heart morphogenesis ISS--
    GO:0006468protein phosphorylation ----
    GO:0007155cell adhesion IDA12734395

    EPHB4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EPHB4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for EPHB4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GTP 14564Class III receptor tyrosine kinase (RTK) inhibitor[34823-86-4]
    NVP BHG 712Potent EphB4 kinase inhibitor[940310-85-0]
    Ki 20227c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation[623142-96-1]

    2 HMDB Compounds for EPHB4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    8 DrugBank Compounds for EPHB4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3-({4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZAMIDE-- --target--10592235
    3-({4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzenesulfonamide-- --target--10592235
    N'-(3-CHLORO-4-METHOXY-PHENYL)-N-(3,4,5-TRIMETHOXYPHENYL)-1,3,5-TRIAZINE-2,4-DIAMINE-- --target--10592235
    N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3,4,5- TRIMETHOXYPHENYL)PYRIMIDINE-2,4-DIAMINE-- --target--10592235
    N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3-MORPHOLIN-4-YLPHENYL)PYRIMIDINE-2,4-DIAMINE-- --target--10592235
    N'-(5-chloro-1,3-benzodioxol-4-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine-- --target--10592235
    N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine-- --target--10592235
    N-[3-[[4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL]AMINO]PHENYL]METHANESULFONAMIDE-- --target--10592235

    3 Novoseek inferred chemical compound relationships for EPHB4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 66 35 8188704 (4), 10221518 (3), 15358160 (2), 16816380 (2) (see all 16)
    vegf 40.8 10 20338920 (3), 19950560 (1), 19923070 (1), 15471957 (1) (see all 6)
    thymidine 38.9 9 7593001 (2), 7969135 (1), 10502302 (1), 10639574 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about EPHB4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EPHB4 gene: 
    NM_004444.4  

    Unigene Cluster for EPHB4:

    EPH receptor B4
    Hs.437008  [show with all ESTs]
    Unigene Representative Sequence: AB209644
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360620 ENST00000358173(uc003uwn.1 uc010lhj.1 uc011kkf.1 uc011kkg.1 uc011kkh.1)
    ENST00000487222(uc003uwm.1) ENST00000492403 ENST00000478459 ENST00000467515
    ENST00000477446 ENST00000489808 ENST00000492878
    miRNA
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    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHB4
    Sirion Biotech Customized lentivirus for stable overexpression of EPHB4 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPHB4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPHB4

    Additional mRNA sequence: 

    AB209644.1 AK301224.1 AY056048.1 BC004264.1 BC052804.1 EU826608.1 EU826609.1 EU826610.1 
    U07695.1 

    12 DOTS entries:

    DT.100689231  DT.100818782  DT.444136  DT.121068866  DT.100818780  DT.121068891  DT.95282899  DT.121068837 
    DT.97845932  DT.91914735  DT.95081702  DT.95282873 

    24/188 AceView cDNA sequences (see all 188):

    BM830054 BC052804 AU133418 BM974102 BM857398 BQ183584 BM795543 BM823021 
    CA487258 BM756028 AY056048 BM742052 AI368193 AI281014 AA369508 BQ670731 
    BE466828 BF475845 AI270622 BU683397 CR621822 AW024723 BM771479 CR620724 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for EPHB4 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17
    SP1:              -                                               -                 -                                                               
    SP2:              -                                               -                 -                                                     -         
    SP3:                                                              -                 -                                                               
    SP4:                                                                                -                                                               
    SP5:                                                                                                  -                                             


    ECgene alternative splicing isoforms for EPHB4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EPHB4 expression in normal human tissues (normalized intensities)      EPHB4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGTTTCCA
    EPHB4 Expression
    About this image


    EPHB4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 9 entries
             Venous Endothelial Cells Pulmonary Capillary Plexus
             PureStem endothelial progenitor 30-SM2-1
             Endothelial-like cells ( Generation of hematopoietic and endothelial progenitor cells...
             blood outgrowth endothelial cell   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             PureStem endothelial progenitor 30-MV2-12
             cd14+ cells   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Venous Endothelial Cells Pulmonary Capillary Plexus
     
     Neural Crest (Gastrulation Derivatives)
             mesenchyme   
     
     Uterus (Reproductive System)
             uterine fibroid tissue   

    See EPHB4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EPHB4

    SOURCE GeneReport for Unigene cluster: Hs.437008

    UniProtKB/Swiss-Prot: EPHB4_HUMAN, P54760
    Tissue specificity: Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal
    muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in
    cell lines derived from liver, breast, colon, lung, melanocyte and cervix

        SABiosciences Expression via Pathway-Focused PCR Array including EPHB4: 
              Angiogenesis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for EPHB4 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ephb41 , 5 Eph receptor B41, 5 86.42(n)1
    92.91(a)1
      5 (76.38 cM)5
    138461  NM_001159571.11  NP_001153043.11 
     1373501095 
    African clawed frog
    (Xenopus laevis)
    Amphibia ephB4a2 eph receptor tyrosine kinase 75.82(n)    AJ236867.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AJ005026.22   -- 78.6(n)   30688  AJ005026.2 


    ENSEMBL Gene Tree for EPHB4 (if available)
    TreeFam Gene Tree for EPHB4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EPHB4 gene
    EPHB12  EPHA22  EPHB32  EPHA42  EPHA52  EPHB62  EPHA62  EPHA12  
    EPHB22  EPHA82  EPHA32  EPHA72  EPHA102  
    18/23 SIMAP similar genes for EPHB4 using alignment to 7 protein entries:     EPHB4_HUMAN (see all proteins) (see all similar genes):
    EPHB3    EPHB1    EPHB2 variant protein    EPHA2    EPHA3    EPHA4
    EPHA7    EPHB2    EPHA6    EPHA8    FRK    EPHA5
    HCK    YES1    EPHA10    EPHB6    LCK    LYN

    EPHB4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/754 SNPs in EPHB4 are shown (see all 754)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0421884
    A gastric adenocarcinoma sample4--see VAR_0421882 R W mis40--------
    VAR_0421834
    A metastatic melanoma sample4--see VAR_0421832 P L mis40--------
    rs2004882591,2
    C--95055009(+) CCCCC-/CGCAAGG 1 -- int10--------
    rs1149419421,2
    C--100399695(+) CACACA/GTGGGG 1 -- ds50010--------
    rs746262601,2
    C,F--100399697(+) CACGTG/TGGGGG 1 -- ds50011Minor allele frequency- T:0.10WA 118
    rs117732811,2
    H--100399704(+) GGGGGG/TCCCTT 1 -- ds50010--------
    rs559822651,2
    C,F--100399802(+) TCCATC/TCACGG 1 -- ds50013Minor allele frequency- T:0.08WA NA EA 358
    rs1489635661,2
    --100399805(+) ATCCAC/TGGAAC 1 -- ds50010--------
    rs1909626041,2
    --100400105(+) TCCAGA/CCCTCT 1 -- ds50010--------
    rs559455031,2
    C--100400124(+) TCGGTA/C/GAGCCA 1 -- ds50015WA CSA NA EA 362

    HapMap Linkage Disequilibrium report for EPHB4 (100400187 - 100425143 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for EPHB4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    dgv7403n71CNV Loss21882294
    dgv7402n71CNV Loss21882294
    nsv470381CNV Loss18288195
    nsv888800CNV Loss21882294
    nsv888796CNV Loss21882294
    dgv2119e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600011    OMIM disorders: --

    42 diseases for EPHB4 (see first 20):    About MalaCards
    conjunctivitis    pyogenic granuloma    proliferative diabetic retinopathy    arteriovenous malformation
    diabetic retinopathy    squamous cell carcinoma of the head and neck    prostate cancer    endometrial carcinoma
    vaccinia    prostatitis    kaposi's sarcoma    rhabdomyosarcoma
    ischemia    cytochrome p450    acute lymphoblastic leukemia    colon cancer
    papillary thyroid carcinoma    endotheliitis    hepatocellular carcinoma    retinitis
    lymphoblastic leukemia    astrocytoma    ovarian cancer    cervical cancer
    thyroid cancer    squamous cell carcinoma    sarcoma    cervicitis
    myeloma    gastric cancer    rheumatoid arthritis    breast cancer
    colorectal cancer    leukemia    arthritis    glioblastoma
    lung cancer    adenocarcinoma    thyroiditis    pancreatitis
    hepatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for EPHB4:
    Cancer

    EPHB4 for disorders           About GeneDecksing

    10/22 Novoseek inferred disease relationships for EPHB4 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinal neovascularization 61.7 1 15914639 (1)
    neovascularization 52.9 2 17133777 (1), 17510705 (1)
    hnscc 47 24 16615113 (4), 17043250 (4), 18794445 (4), 14661437 (2)
    cancer 32.9 14 19552627 (3), 17108150 (1), 19879134 (1), 17241664 (1) (see all 9)
    proliferative diabetic retinopathy 31.3 1 17133777 (1)
    tumors 29.5 59 16816380 (4), 19366806 (4), 16615113 (3), 20133814 (3) (see all 26)
    endometrial carcinoma 25.2 4 11295082 (2), 12562648 (1)
    carcinoma squamous cell 24.1 8 16615113 (2), 17043250 (2), 18794445 (2), 17611172 (1) (see all 5)
    retinopathy 21.2 5 15914639 (2), 15289137 (1), 20503366 (1), 19232363 (1)
    ovarian cancer 20 10 18231102 (4), 17353927 (2), 18281782 (2)

    Genetic Association Database (GAD): EPHB4
    Human Genome Epidemiology (HuGE) Navigator: EPHB4 (1 document)

    Export disorders for EPHB4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EPHB4 gene, integrated from 9 sources (see all 173):
    (articles sorted by number of sources associating them with EPHB4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily. (PubMed id 8188704)1, 2, 3, 9 Bennett B.D.... Scadden D.T. (1994)
    2. Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells. (PubMed id 12734395)1, 2, 9 Fuller T....Augustin H.G. (2003)
    3. Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity. (PubMed id 16867992)1, 2, 9 Chrencik J.E....Kuhn P. (2006)
    4. EphB4 controls blood vascular morphogenesis during postnatal angiogenesis. (PubMed id 16424904)1, 2, 9 Erber R....Vajkoczy P. (2006)
    5. EPHB4 gene polymorphisms and risk of intracranial hem orrhage in patients with brain arteriovenous malformations. (PubMed id 20031623)1, 4 Weinsheimer S....Young W.L. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. (PubMed id 11239002)1, 2 Wilson M.D....Koop B.F. (2001)
    8. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PubMed id 9267020)1, 2 (1997)
    9. Receptor tyrosine kinase, EphB4 (HTK), accelerates differentiation of select human hematopoietic cells. (PubMed id 11929761)1, 9 Wang Z....Scadden D.T. (2002)
    10. EphB4 expression and biological significance in prostate cancer. (PubMed id 15930280)1, 9 Xia G....Gill P.S. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2050 HGNC: 3395 AceView: EPHB4 Ensembl:ENSG00000196411 euGenes: HUgn2050
    ECgene: EPHB4 Kegg: 2050 H-InvDB: EPHB4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EPHB4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EPHB4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EPHB4 gene:
    Search GeneIP for patents involving EPHB4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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