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EPHB3 Gene

protein-coding   GIFtS: 71
GCID: GC03P184279

EPH Receptor B3

(Previous name: EphB3)
(Previous symbol: ETK2)
  See EPHB3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
EPH Receptor B31 2     EPH-Like Tyrosine Kinase 22 3
ETK21 2 3 5     EC 2.7.10.13 8
Embryonic Kinase 22 3     EphB31
Tyrosine-Protein Kinase TYRO62 3     EPH-Like Tyrosine Kinase-22
EK22 3     Ephrin Type-B Receptor 32
HEK22 3     Human Embryo Kinase 22
TYRO62 3     hEK23
EPH-Like Kinase 22 3     EC 2.7.108

External Ids:    HGNC: 33941   Entrez Gene: 20492   Ensembl: ENSG000001825807   OMIM: 6018395   UniProtKB: P547533   

Export aliases for EPHB3 gene to outside databases

Previous GC identifers: GC03P180979 GC03U900008 GC03P185682 GC03P185600 GC03P185762 GC03P181691


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EPHB3 Gene:
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the
nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A
(EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B
(EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on
the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B
ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene
encodes a receptor for ephrin-B family members. (provided by RefSeq, Mar 2010)

GeneCards Summary for EPHB3 Gene:
EPHB3 (EPH receptor B3) is a protein-coding gene. Diseases associated with EPHB3 include spinal cord ependymoma. GO annotations related to this gene include ephrin receptor activity and axon guidance receptor activity. An important paralog of this gene is EPHB1.

UniProtKB/Swiss-Prot: EPHB3_HUMAN, P54753
Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on
adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with
EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the
corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of
the cerebral cortex. Beside its role in axon guidance plays also an important redundant role with other ephrin-B
receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls
other aspects of development through regulation of cell migration and positioning. This includes angiogenesis,
palate development and thymic epithelium development for instance. Forward and reverse signaling through the
EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the
cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from
differentiated cells in the crypt

Gene Wiki entry for EPHB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the EPHB3 gene promoter:
         Max1   AP-1   AML1a   NF-kappaB   Evi-1   FOXO4   Sox9   NF-kappaB1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEPHB3 promoter sequence
   Search Chromatin IP Primers for EPHB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EPHB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27.1   Ensembl cytogenetic band:  3q27.1   HGNC cytogenetic band: 3q27.1

EPHB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHB3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P184279:  view genomic region     (about GC identifiers)

Start:
184,279,572 bp from pter      End:
184,300,197 bp from pter
Size:
20,626 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: EPHB3_HUMAN, P54753 (See protein sequence)
Recommended Name: Ephrin type-B receptor 3 precursor  
Size: 998 amino acids; 110330 Da
Subunit: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a
receptor dimer. Oligomerization is probably required to induce biological responses (By similarity)
2 PDB 3D structures from and Proteopedia for EPHB3:
3P1I (3D)        3ZFY (3D)    
Secondary accessions: Q7Z740

Explore the universe of human proteins at neXtProt for EPHB3: NX_P54753

Explore proteomics data for EPHB3 at MOPED

Post-translational modifications: 

  • Phosphorylated. Autophosphorylates upon ligand-binding. Autophosphorylation on Tyr-614 is required for interaction
    with SH2 domain-containing proteins1
  • Glycosylation2 at Asn351, Asn445
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for EPHB3 (P54753) (see all 48)
     MSNQDVI  QDMRLQM  RDLAARN  QNNWLRT 


    See EPHB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004434.2  
    ENSEMBL proteins: 
     ENSP00000332118  

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    antibodies-online proteins for EPHB3 (6 products) 

     
    antibodies-online peptides for EPHB3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    EPH: EPH receptors
    SAMD: Sterile alpha motif (SAM) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: EPH receptor B3
    Ephrin receptor family
    Ephrin receptor family

    Selected InterPro protein domains (see all 17):
     IPR017441 Protein_kinase_ATP_BS
     IPR003961 Fibronectin_type3
     IPR021129 SAM_type1
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P54753

    ProtoNet protein and cluster: P54753

    5 Blocks protein domains:
    IPB001090 Ephrin receptor
    IPB001426 Receptor tyrosine kinase
    IPB001660 Sterile alpha motif SAM
    IPB003962 Fibronectin type III repeat signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EPHB3_HUMAN, P54753
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Find genes that share domains with EPHB3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EPHB3_HUMAN, P54753
    Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on
    adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
    pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
    the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with
    EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the
    corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of
    the cerebral cortex. Beside its role in axon guidance plays also an important redundant role with other ephrin-B
    receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls
    other aspects of development through regulation of cell migration and positioning. This includes angiogenesis,
    palate development and thymic epithelium development for instance. Forward and reverse signaling through the
    EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the
    cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from
    differentiated cells in the crypt
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for EPHB3:
    EPH-related tyrosine kinase receptor,binding ephrins B,expressed in projecting neurons and their target
    fields,involved in short-range contact-mediated exonal guidance,human embryonic kinase 2,expressed in various
    tissues

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0005003ephrin receptor activity IDA15536074
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with EPHB3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for EPHB3:
     Decreased focal adhesion (FA)   Decreased mitotic index 

         12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ephb3):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hearing/vestibular/ear  mortality/aging  nervous system  renal/urinary system 
     reproductive system  vision/eye 

    Find genes that share phenotypes with EPHB3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ephb3tm1Kln for EPHB3

       genOway: Develop your customized and physiologically relevant rodent model for EPHB3

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate EPHB3 (see all 21):
    hsa-miR-16-2* hsa-miR-137 hsa-miR-330-5p hsa-miR-29a hsa-miR-29c hsa-miR-1908 hsa-miR-3921 hsa-miR-339-5p
    SwitchGear 3'UTR luciferase reporter plasmidEPHB3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: EPHB3 (NM_004443)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHB3
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    Addgene plasmids for EPHB3 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EPHB3_HUMAN, P54753: Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    extracellular2
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane IDA15536074
    GO:0030425dendrite IEA--

    Find genes that share ontologies with EPHB3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EPHB3 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    Ephrin-Eph Signaling0.58
    2EPHB forward signaling
    EPHB forward signaling0.30
    EphrinB-EPHB pathway0.00
    Cell adhesion Ephrins signaling0.30
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48


    Find genes that share SuperPaths with EPHB3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EPHB3 (see all 31)
        MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Ephrin-Eph Signaling

    2 GeneGo (Thomson Reuters) Pathways for EPHB3
        Cytoskeleton remodeling Reverse signaling by ephrin B
    Cell adhesion Ephrins signaling

    2 BioSystems Pathways for EPHB3
        EPHB forward signaling
    EphrinB-EPHB pathway



    1 Kegg Pathway  (Kegg details for EPHB3):
        Axon guidance

        Pathway & Disease-focused RT2 Profiler PCR Array including EPHB3: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for EPHB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for EPHB3 (P547532, 3 ENSP000003321184) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLLT4P551962, 3, ENSP000003836234MINT-58214 I2D: score=3 STRING: ENSP00000383623
    CRKP461083, ENSP000003005744I2D: score=2 STRING: ENSP00000300574
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    RASA1P209363, ENSP000002743764I2D: score=2 STRING: ENSP00000274376
    RYKP349253, ENSP000002960844I2D: score=2 STRING: ENSP00000296084
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis ISS--
    GO:0001655urogenital system development ISS--
    GO:0006468protein phosphorylation ----
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway ----
    GO:0007411axon guidance ISS--

    Find genes that share ontologies with EPHB3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EPHB3

    2 HMDB Compounds for EPHB3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 Novoseek inferred chemical compound relationship for EPHB3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 48.4 3 17906625 (1), 7838529 (1), 15090252 (1)



    Find genes that share compounds with EPHB3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EPHB3 gene: 
    NM_004443.3  

    Unigene Cluster for EPHB3:

    EPH receptor B3
    Hs.2913  [show with all ESTs]
    Unigene Representative Sequence: NM_004443
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330394(uc003foz.3) ENST00000482987 ENST00000473079
    miRNA
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    hsa-miR-16-2* hsa-miR-137 hsa-miR-330-5p hsa-miR-29a hsa-miR-29c hsa-miR-1908 hsa-miR-3921 hsa-miR-339-5p
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      QuantiTect SYBR Green Assays in human, mouse, rat EPHB3
      QuantiFast Probe-based Assays in human, mouse, rat EPHB3

    Additional mRNA sequence: 

    BC052968.1 X75208.1 

    4 DOTS entries:

    DT.413845  DT.99934413  DT.87015633  DT.95259798 

    Selected AceView cDNA sequences (see all 91):

    R75999 BX951267 BQ922013 BE902753 BC052968 NM_004443 BM818683 F08641 
    BQ230511 AA633797 AW177570 BF315802 AI918407 BU624938 BG676983 BQ671492 
    BG740889 CA488641 BQ771613 BQ070254 BU845117 BF766477 BF312946 BG746559 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for EPHB3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16
    SP1:                                      -                       -                                               -                                 
    SP2:                                                                                                        -     -     -                           
    SP3:                                                              -                                                                                 
    SP4:                                                                                                                                                
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for EPHB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EPHB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGAGCGTG
    EPHB3 Expression
    About this image


    EPHB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
     
     Neural Tube (Nervous System)
             Floor plate-like cells
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    EPHB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EPHB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2913

    UniProtKB/Swiss-Prot: EPHB3_HUMAN, P54753
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including EPHB3: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for EPHB3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ephb31 , 5 Eph receptor B31, 5 89.03(n)1
    97.31(a)1
      16 (12.62 cM)5
    138451  NM_010143.11  NP_034273.11 
     212047555 
    chicken
    (Gallus gallus)
    Aves EPHB31 EPH receptor B3 80.52(n)
    87.29(a)
      396179  XM_422762.4  XP_422762.4 
    lizard
    (Anolis carolinensis)
    Reptilia EPHB36
    EPH receptor B3
    86(a)
    1 ↔ 1
    GL343321.1(1033689-1156235)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3978342 Eph receptor tyrosine kinase 74.89(n)    L43620.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ek32 eph-like kinase 3 76.08(n)   30313  AF369382.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Eph3 protein amino acid phosphorylation
    transmembrane more
    39(a)
    (best of 2)
      102C2   --


    ENSEMBL Gene Tree for EPHB3 (if available)
    TreeFam Gene Tree for EPHB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EPHB3 gene
    EPHB12  EPHA22  EPHA42  EPHA52  EPHB62  EPHA62  EPHA12  EPHB22  
    EPHA82  EPHA32  EPHA72  EPHA102  EPHB42  
    Selected SIMAP similar genes for EPHB3 using alignment to 2 protein entries:     EPHB3_HUMAN (see all proteins) (see all similar genes):
    EPHB1    EPHB2 variant protein    EPHB2    EPHA3    EPHA4    EPHA2
    EPHA7    EPHA6    EPHB4    EPHA5    ABL1    EPHA8
    EPHB6    FES    EPHA10    tec    BTK kinase deficient isoform 2    FGR

    Find genes that share paralogs with EPHB3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EPHB3 (see all 576)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0421764
    A lung small cell carcinoma sample4--see VAR_0421762 R L mis40--------
    VAR_0421804
    A lung neuroendocrine carcinoma sample4--see VAR_0421802 R W mis40--------
    rs793481731,2
    C,F--184277676(+) CCCCAT/GGTACC 1 -- us2k12Minor allele frequency- G:0.08CSA WA 119
    rs1928886981,2
    --184277684(+) ACCCAC/TACATG 1 -- us2k10--------
    rs1858804771,2
    --184277707(+) ACCAGC/GAGGAC 1 -- us2k10--------
    rs98592411,2
    C,F--184277813(+) AGAGGA/TCTAAG 1 -- us2k11Minor allele frequency- T:0.12WA 118
    rs117133411,2
    C,F,A,H--184278103(+) CTAGGT/CCCTCT 1 -- us2k120Minor allele frequency- C:0.25EA NS NA WA 2118
    rs1156877131,2
    F--184278110(+) CTCTGT/CAGGTT 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs117094141,2
    C,F,H--184278371(+) TTGACG/ATCCTC 1 -- us2k117Minor allele frequency- A:0.25EA NS NA WA 2116
    rs1903034991,2
    --184278571(+) ATGCTC/TCCCAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for EPHB3 (184279572 - 184300197 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for EPHB3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508972CNV Insertion20534489
    nsv829814CNV Loss17160897
    nsv461034CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601839    OMIM disorders: --

    1 disease for EPHB3:    
    About MalaCards
    spinal cord ependymoma

    1 disease from the University of Copenhagen DISEASES database for EPHB3:
    Spinal cord ependymoma

    Find genes that share disorders with EPHB3           About GenesLikeMe

    1 Novoseek inferred disease relationship for EPHB3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 9.58 8 19483190 (3), 18281782 (2), 16516143 (1), 9075249 (1)

    Genetic Association Database (GAD): EPHB3
    Human Genome Epidemiology (HuGE) Navigator: EPHB3 (3 documents)

    Export disorders for EPHB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EPHB3 gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with EPHB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2. (PubMed id 8397371)1, 2, 3 Boehme B.... Ruebsamen-Waigmann H. (Oncogene 1993)
    2. Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases. (PubMed id 15536074)1, 2, 9 Miao H.... Wang B. (J. Biol. Chem. 2005)
    3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    4. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (Genet. Med. 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions. (PubMed id 9674711)1, 2 Hock B....Strebhardt K. (Oncogene 1998)
    7. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PubMed id 9267020)1, 2 (Cell 1997)
    8. Over-expression of EphB3 enhances cell-cell contacts and suppresses tumor growth in HT-29 human colon cancer cells. (PubMed id 19483190)1, 9 Chiu S.T....Hsieh F.J. (Carcinogenesis 2009)
    9. Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro. (PubMed id 9751130)1, 9 Ciossek T....Drescher U. (Eur. J. Neurosci. 1998)
    10. EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex. (PubMed id 22314363)1 Li G....Xie D. (Nat Commun 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2049 HGNC: 3394 AceView: EPHB3 Ensembl:ENSG00000182580 euGenes: HUgn2049
    ECgene: EPHB3 Kegg: 2049 H-InvDB: EPHB3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EPHB3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EPHB3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EPHB3 gene:
    Search GeneIP for patents involving EPHB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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