EPHB3 Gene
protein-coding GIFtS: 67
GCID: GC03P184279
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|
EPH receptor B3(Previous name: EphB3 )
(Previous symbol: ETK2)
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Aliases
for EPHB3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| EPH Receptor B31 2 | | EC 2.7.10.13 8 | | ETK21 2 3 5 | | EphB31 | | Embryonic Kinase 22 3 | | Hek21 | | Tyrosine-Protein Kinase TYRO62 3 | | Tyro61 | | EK22 3 | | EPH-Like Tyrosine Kinase-22 | | HEK22 3 | | Ephrin Type-B Receptor 32 | | TYRO62 3 | | Human Embryo Kinase 22 | | EPH-Like Kinase 22 3 | | HEK22 3 | | EPH-Like Tyrosine Kinase 22 3 | | EC 2.7.108 |
Export aliases for EPHB3 gene to outside databasesPrevious GC identifers: GC03P180979 GC03U900008 GC03P185682 GC03P185600 GC03P185762 GC03P181691 |
Summaries
for EPHB3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for EPHB3:
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervoussystem. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class,which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which aretransmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of theirextracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors makeup the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B familymembers. (provided by RefSeq, Mar 2010)
UniProtKB/Swiss-Prot: EPHB3_HUMAN, P54753Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacentcells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstreamof the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand isreferred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2,functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and theanterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. Besideits role in axon guidance plays also an important redundant role with other ephrin-B receptors in development andmaturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development throughregulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epitheliumdevelopment for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration andadhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinalepithelium differentiation segregating progenitor from differentiated cells in the crypt
Gene Wiki entry for EPHB3
|
Genomic Views
for EPHB3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the EPHB3 gene promoter:
Max1 AP-1 AML1a NF-kappaB Evi-1 FOXO4 Sox9 NF-kappaB1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for EPHB3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPHB3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q21-qter Ensembl cytogenetic band: 3q27.1 HGNC cytogenetic band: 3q21-qterEPHB3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P184279: view genomic region
(about GC identifiers)
Start:
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184,279,572 bp from pter |
End:
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184,300,197 bp from pter |
Size:
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20,626 bases |
Orientation:
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plus strand |
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Proteins
for EPHB3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EPHB3_HUMAN, P54753 (See
protein sequence)Recommended Name: Ephrin type-B receptor 3 precursor Size: 998 amino acids; 110330 Da
Subunit: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptordimer. Oligomerization is probably required to induce biological responses (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite (By similarity)
1 PDB 3D structure from  and Proteopedia  for EPHB3:3P1I (3D)
Secondary accessions: Q7Z740Explore the universe of human proteins at neXtProt for EPHB3: NX_P54753
Post-translational modifications:
Phosphorylated. Autophosphorylates upon ligand-binding. Autophosphorylation on Tyr-614 is required for interaction withSH2 domain-containing proteins1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P54753
4/48 DME Specific Peptides for EPHB3 (P54753) (see all 48)
EPHB3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004434.2
ENSEMBL proteins: ENSP00000332118
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
EPHB3 for ontologies About GeneDecksing
EPHB3 Antibody Products:
Assay Products for EPHB3: |
Protein
Domains /
Families
for EPHB3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
EPHB3 for domains About GeneDecksing
5/16 InterPro domains/families (see all 16):Graphical View of Domain Structure for InterPro Entry P54753ProtoNet protein and cluster: P54753 5 Blocks protein families: IPB001090 Ephrin receptor IPB001426 Receptor tyrosine kinase IPB001660 Sterile alpha motif SAM IPB003962 Fibronectin type III repeat signature IPB008266 Tyrosine protein kinase
UniProtKB/Swiss-Prot: EPHB3_HUMAN, P54753Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamilySimilarity: Contains 1 Eph LBD (Eph ligand-binding) domainSimilarity: Contains 2 fibronectin type-III domainsSimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 SAM (sterile alpha motif) domain |
Function
for EPHB3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: EPHB3_HUMAN, P54753Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacentcells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstreamof the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand isreferred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2,functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and theanterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. Besideits role in axon guidance plays also an important redundant role with other ephrin-B receptors in development andmaturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development throughregulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epitheliumdevelopment for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration andadhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinalepithelium differentiation segregating progenitor from differentiated cells in the cryptCatalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate Genatlas biochemistry entry for EPHB3:EPH-related tyrosine kinase receptor,binding ephrins B,expressed in projecting neurons and their target fields,involvedin short-range contact-mediated exonal guidance,human embryonic kinase 2,expressed in various tissues
Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EPHB3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EPHB3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: EPHB3 (NM_004443) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EPHB3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHB3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHB3 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
EPHB3 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for EPHB3:
Animal Models:
Mouse knock-out Ephb3tm1Kln for EPHB3
12 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ephb3):
EPHB3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for EPHB3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | GPCR Pathway | | | 2 | Rho Family GTPases | | | 3 | Nanog in Mammalian ESC Pluripotency | | | 4 | Actin Nucleation by ARP-WASP Complex | | | 5 | Cell adhesion_Ephrins signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for EPHB3
5/31 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EPHB3 (see all 31)
2  GeneGo (Thomson Reuters) Pathways for EPHB3
2  BioSystems Pathways for EPHB3
1 
Kegg Pathway (Kegg details for EPHB3):
EPHB3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EPHB3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/14 Interacting proteins for EPHB3 (P547532, 3 ENSP000003321184) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21): About this table
EPHB3 for ontologies About GeneDecksing
|
Drugs & Compounds
for EPHB3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
EPHB3 for compounds About GeneDecksing
 Browse Tocris compounds for EPHB3
2 HMDB Compounds for EPHB3 About this table
1 Novoseek chemical compound relationship for EPHB3 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
48.4 |
3 |
17906625 (1), 7838529 (1), 15090252 (1) |
Search CenterWatch for drugs/clinical trials and news about EPHB3
|
Transcripts
for EPHB3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for EPHB3 gene: NM_004443.3 Unigene Cluster for EPHB3: EPH receptor B3 Hs.2913 [show with all ESTs]Unigene Representative Sequence: NM_0044433 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000330394(uc003foz.3) ENST00000482987 ENST00000473079
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EPHB3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EPHB3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: EPHB3 (NM_004443) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EPHB3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHB3 |
Additional cDNA sequence: BC052968.1 X75208.1 4 DOTS entries: DT.413845 DT.99934413 DT.87015633 DT.95259798 24/91 AceView cDNA sequences (see all 91): BQ230511 AA633797 BX951267 BE902753 BQ922013 R75999 F08641 BC052968 NM_004443 AW177570 BM818683 BE382946 AI918407 CF147273 BG481991 BF312946 BQ771613 BG676983 BQ070254 BG746559 BV207919 CA311715 AI888091 AA460789
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for EPHB3 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for EPHB3
|
Expression
for EPHB3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| EPHB3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTGAGCGTG
About this image
See EPHB3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for EPHB3
SOURCE GeneReport for Unigene cluster: Hs.2913
UniProtKB/Swiss-Prot: EPHB3_HUMAN, P54753Tissue specificity: Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Array including EPHB3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EPHB3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EPHB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPHB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPHB3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHB3 |
Orthologs
for EPHB3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for EPHB3 gene from 6/22 species (see all 22) About this table
ENSEMBL Gene Tree for EPHB3 (if available)
TreeFam Gene Tree for EPHB3 (if available) |
Paralogs
for EPHB3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for EPHB3 gene
- EPHB12 EPHA22 EPHA42 EPHA52 EPHB62 EPHA62 EPHB22 EPHA12
- EPHA82 EPHA32 EPHA72 EPHB42 EPHA102
18/35 SIMAP similar genes for EPHB3 using alignment to 2 protein entries: EPHB3_HUMAN (see all proteins)
(see all similar genes):EPHB1 EPHB2 variant protein EPHB2 EPHA3 EPHA4 EPHA2
EPHA7 EPHA6 EPHB4 EPHA5 ABL1 EPHA8
EPHB6 FES EPHA10 tec BTK kinase deficient isoform 2 FGR
EPHB3 for paralogs About GeneDecksing
|
Genomic Variants
for EPHB3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for EPHB3 (184279572 - 184300197 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for EPHB3
1 CNV: 4365 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EPHB3 |
|
Disorders
/ Diseases
for EPHB3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
EPHB3 for disorders About GeneDecksing
OMIM gene information: 601839
OMIM disorders: --
20  diseases for EPHB3: About MalaCardscleft lip/palate cleft lip corpus callosum squamous cell carcinoma
hemangioma skin cancer colon carcinoma colon cancer
ovarian cancer prostate carcinoma colorectal cancer lung cancer
carcinoma cerebritis retinitis prostatitis
neuronitis breast cancer adenocarcinoma pancreatitis
1 disease from the University of Copenhagen DISEASES database for EPHB3:Spinal cord ependymoma 1 Novoseek disease relationship for EPHB3 gene About this table
Human Genome Epidemiology (HuGE) Navigator: EPHB3 (3 documents)
Export disorders for EPHB3 gene to outside databases
|
Publications
for EPHB3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for EPHB3 gene, integrated from 9 sources (see all 51):
(articles sorted by number of sources associating them with EPHB3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2. (PubMed id 8397371)1, 2, 3 Boehme B.... Ruebsamen-Waigmann H. (1993)
- Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases. (PubMed id 15536074)1, 2, 9 Miao H....Wang B. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions. (PubMed id 9674711)1, 2 Hock B....Strebhardt K. (1998)
- Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PubMed id 9267020)1, 2 (1997)
- Over-expression of EphB3 enhances cell-cell contacts and suppresses tumor growth in HT-29 human colon cancer cells. (PubMed id 19483190)1, 9 Chiu S.T....Hsieh F.J. (2009)
- Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro. (PubMed id 9751130)1, 9 Ciossek T....Drescher U. (1998)
- EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex. (PubMed id 22314363)1 Li G....Xie D. (2012)
- Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling. (PubMed id 21804545)1 Solanas G....Batlle E. (2011)
- Biochemical and computational analysis of LNX1 interac ting proteins. (PubMed id 22087225)1 Wolting C.D....McGlade C.J. (2011)
|
External Searches for EPHB3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing EPHB3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing EPHB3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing EPHB3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for EPHB3 gene:
Search GeneIP for patents involving EPHB3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for EPHB3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | OriGene Antibodies for EPHB3 | | OriGene shRNA RFP for EPHB3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EPHB3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EPHB3 | | | OriGene Protein Over-expression Lysate for EPHB3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for EPHB3 | | OriGene 3'-UTR Clone for EPHB3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EPHB3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EPHB3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for EPHB3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for EPHB3 | | OriGene Custom Protein Services for EPHB3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat EPHB3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing EPHB3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPHB3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPHB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPHB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPHB3 |
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| | | | Search Tocris compounds for EPHB3 |
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 | | | EPHB3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHB3 |
|  |  |  | | | | ThermoFisher Antibody for EPHB3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHB3 |
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