Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



EPHB2 Gene

protein-coding   GIFtS: 75
GCID: GC01P023037

EPH Receptor B2

(Previous name: EphB2)
(Previous symbols: DRT, ERK, EPHT3)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
EPH Receptor B21 2     CAPB2 5
DRT1 2 3 5     PCBC2 5
EPHT31 2 3 5     EphB21
ERK1 2 3 5     Hek52
Developmentally-Regulated Eph-Related Tyrosine Kinase2 3     Tyro52
ELK-Related Tyrosine Kinase2 3     Ephrin Type-B Receptor 22
EPH Tyrosine Kinase 32 3     Protein-Tyrosine Kinase HEK52
Renal Carcinoma Antigen NY-REN-472 3     EPTH33
Tyrosine-Protein Kinase Receptor EPH-32 3     HEK53
Tyrosine-Protein Kinase TYRO52 3     TYRO53
EK52 3     hEK53
EPH-Like Kinase 52 3     EC 2.7.108
EC 2.7.10.13 8     

External Ids:    HGNC: 33931   Entrez Gene: 20482   Ensembl: ENSG000001332167   OMIM: 6009975   UniProtKB: P293233   

Export aliases for EPHB2 gene to outside databases

Previous GC identifers: GC01P022677 GC01P022143 GC01P022506 GC01P022782 GC01P022910 GC01P021351


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for EPHB2 Gene:
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the
nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A
(EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B
(EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on
the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B
ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein
encoded by this gene is a receptor for ephrin-B family members. (provided by RefSeq, Jul 2008)

GeneCards Summary for EPHB2 Gene:
EPHB2 (EPH receptor B2) is a protein-coding gene. Diseases associated with EPHB2 include prostate cancer, progression and metastasis of, and prostate cancer, progression of. GO annotations related to this gene include transmembrane-ephrin receptor activity and receptor binding. An important paralog of this gene is EPHB1.

UniProtKB/Swiss-Prot: EPHB2_HUMAN, P29323
Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on
adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in
the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of
the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline
and of retinal ganglion cell axons to the optic disk. Beside axon guidance, also regulates dendritic spines
development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1,
abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of
development including angiogenesis, palate development and in inner ear development through regulation of
endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and
adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor

Gene Wiki entry for EPHB2 (EPH receptor B2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EPHB2 gene promoter:
         CREB   ATF-2   deltaCREB   STAT3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for EPHB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EPHB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.1-p35   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.1-p35

EPHB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHB2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P023037:  view genomic region     (about GC identifiers)

Start:
23,037,331 bp from pter      End:
23,241,823 bp from pter
Size:
204,493 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: EPHB2_HUMAN, P29323 (See protein sequence)
Recommended Name: Ephrin type-B receptor 2 precursor  
Size: 1055 amino acids; 117493 Da
Subunit: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a
receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts
(via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain) (By similarity). Interacts with ARHGEF15; mediates
ARHGEF15 phosphorylation, ubiquitination and degradation by the proteasome. Interacts with AQP1; involved in
endolymph production in the inner ear
4 PDB 3D structures from and Proteopedia for EPHB2:
1B4F (3D)        1F0M (3D)        2QBX (3D)        3ZFM (3D)    
Secondary accessions: O43477 Q5T0U6 Q5T0U7 Q5T0U8
Alternative splicing: 3 isoforms:  P29323-1   P29323-2   P29323-3   (No experimental confirmation available. Contains a phosphoserine at position 984)

Explore the universe of human proteins at neXtProt for EPHB2: NX_P29323

Explore proteomics data for EPHB2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn265, Asn336, Asn428, Asn482
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for EPHB2 (P29323) (see all 48)
     PVMIITE  RDLAARN  LDSFLRQ  QNNWLRT 


    See EPHB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004433.2  NP_059145.2  

    ENSEMBL proteins: 
     ENSP00000363761   ENSP00000383053   ENSP00000363763   ENSP00000363758   ENSP00000444174  
    Reactome Protein details: P29323

    EPHB2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant EPHB2 Protein
    R&D Systems Recombinant & Natural Proteins for EPHB2
    Enzo Life Sciences proteins for EPHB2
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for EPHB2
    GenScript Custom Purified and Recombinant Proteins Services for EPHB2
    Novus Biologicals EPHB2 Proteins
    Browse Sino Biological Recombinant Proteins
    Sino Biological Cell Lysate for EPHB2
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EPHB2

    EPHB2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of EPHB2
    R&D Systems Antibodies for EPHB2
    OriGene Antibodies for EPHB2
    OriGene Custom Antibody Services for EPHB2
    Novus Biologicals EPHB2 Antibodies
    Abcam antibodies for EPHB2
    Cloud-Clone Corp. Antibodies for EPHB2
    ThermoFisher Antibody for EPHB2
    LSBio Antibodies in human, mouse, rat for EPHB2

    EPHB2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for EPHB2
    R&D Systems Proteome Profiler Antibody Arrays for EPHB2
    GenScript EPHB2-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EPHB2
    Cloud-Clone Corp. CLIAs for EPHB2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    EPH: EPH receptors
    SAMD: Sterile alpha motif (SAM) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: EPH receptor B2
    Ephrin receptor family
    Ephrin receptor family

    Selected InterPro protein domains (see all 18):
     IPR017441 Protein_kinase_ATP_BS
     IPR003961 Fibronectin_type3
     IPR021129 SAM_type1
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P29323

    ProtoNet protein and cluster: P29323

    5 Blocks protein domains:
    IPB001090 Ephrin receptor
    IPB001426 Receptor tyrosine kinase
    IPB001660 Sterile alpha motif SAM
    IPB003962 Fibronectin type III repeat signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EPHB2_HUMAN, P29323
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    EPHB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EPHB2_HUMAN, P29323
    Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on
    adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
    pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
    the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in
    the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of
    the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline
    and of retinal ganglion cell axons to the optic disk. Beside axon guidance, also regulates dendritic spines
    development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1,
    abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of
    development including angiogenesis, palate development and in inner ear development through regulation of
    endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and
    adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for EPHB2:
    EPH-related tyrosine kinase receptor,binding ephrins B,expressed in projecting neurons and their target
    fields,involved in short-range contact-mediated axonal guidance,developmentally regulated,expressed in brain,and
    other tissues,likely involved in neurogenesis and oncogenesis (neuroblastoma,SCLC),phosphorylating and
    interacting with RRAS to control integrin activity

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ISS--
    GO:0004872receptor activity ----
    GO:0005003ephrin receptor activity ----
    GO:0005005transmembrane-ephrin receptor activity TAS8589679
         
    EPHB2 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for EPHB2:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased S DNA content  Increased cell number in G2M,  
     Upregulation of Wnt/beta-caten  Weaker migration 

         12 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Ephb2):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hearing/vestibular/ear  mortality/aging  nervous system  renal/urinary system 
     reproductive system  vision/eye 

    EPHB2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ephb2tm1Paw for EPHB2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EPHB2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EPHB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EPHB2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EPHB2

    miRNA
    Products:
        
    miRTarBase miRNAs that target EPHB2:
    hsa-mir-92a-3p (MIRT049727)

    Block miRNA regulation of human, mouse, rat EPHB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EPHB2 (see all 43):
    hsa-miR-4254 hsa-miR-3607-3p hsa-miR-128 hsa-miR-30d hsa-miR-548m hsa-miR-9 hsa-miR-30a hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidEPHB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EPHB2
    Predesigned siRNA for gene silencing in human, mouse, rat EPHB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for EPHB2

    Clone
    Products:
         
    OriGene clones in human, mouse for EPHB2 (see all 12)
    OriGene ORF clones in mouse, rat for EPHB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): EPHB2 (NM_004442)
    Sino Biological Human cDNA Clone for EPHB2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHB2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for EPHB2
    Browse ESI BIO Cell Lines and PureStem Progenitors for EPHB2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHB2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    EPHB2_HUMAN, P29323: Cell membrane; Single-pass type I membrane protein. Cell projection, axon (By similarity).
    Cell projection, dendrite (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    extracellular2
    endoplasmic reticulum1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane ISS--
    GO:0016021integral component of membrane ----
    GO:0030424axon ISS--
    GO:0030425dendrite ISS--
    GO:0043025neuronal cell body IEA--

    EPHB2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for EPHB2 About   (see all 19)                                                                                              See pathways by source

    SuperPathContained pathways About
    1EPHB forward signaling
    EPHB forward signaling0.30
    MAP kinase cascade0.00
    Cell adhesion Ephrins signaling0.30
    EphrinB-EPHB pathway0.00
    2EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    Ephrin-Eph Signaling0.58
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EPHB2 (see all 31)
        MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Ephrin-Eph Signaling

    2 GeneGo (Thomson Reuters) Pathways for EPHB2
        Cytoskeleton remodeling Reverse signaling by ephrin B
    Cell adhesion Ephrins signaling

    Selected BioSystems Pathways for EPHB2 (see all 8)
        Keap1-Nrf2 Pathway
    NLR proteins
    Syndecan-2-mediated signaling events
    Ephrin B reverse signaling
    EPHB forward signaling


    1 Reactome Pathway for EPHB2
        L1CAM interactions


    1 Kegg Pathway  (Kegg details for EPHB2):
        Axon guidance


    EPHB2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including EPHB2: 
              TGFB Signaling Targets in human mouse rat
              Tumor Metastasis in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for EPHB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EPHB2 (P293231, 2, 3 ENSP000003637634) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUP153P497901, 2, 3, ENSP000002620774EBI-1059294,EBI-286779 MINT-4300391 MINT-4300355 I2D: score=1 STRING: ENSP00000262077
    MLLT4P551962, 3, ENSP000003836234MINT-58184 I2D: score=5 STRING: ENSP00000383623
    EFNB2P527993, ENSP000002453234I2D: score=5 STRING: ENSP00000245323
    ABL1P005193, ENSP000003614234I2D: score=3 STRING: ENSP00000361423
    EFNA5P528033, ENSP000003287774I2D: score=3 STRING: ENSP00000328777
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0001525angiogenesis ISS--
    GO:0001655urogenital system development ISS--
    GO:0006468protein phosphorylation ----
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway ----

    EPHB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EPHB2

    2 HMDB Compounds for EPHB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 DrugBank Compound for EPHB2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for EPHB2 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 73.7 66 9233798 (3), 9864179 (3), 11494128 (3), 10378896 (3) (see all 40)
    pd 98,059 46.9 5 10754327 (1), 20046096 (1), 15245433 (1), 9864179 (1) (see all 5)
    n-formylmethionyl-leucylphenylalanine 44.9 2 18328147 (1), 10378896 (1)
    sb 203580 40.4 1 10378896 (1)
    phosphatidylinositol 30.8 4 18091748 (1), 17763432 (1), 12519307 (1), 15821731 (1)
    fmlp 10.2 6 10378896 (4), 12954601 (1)
    superoxide 8.76 3 18328147 (1), 10378896 (1)
    serine 3.76 3 12731668 (1), 11583608 (1)
    lysine 0 1 10391888 (1)
    phosphoinositide 0 1 10754327 (1)



    EPHB2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for EPHB2 gene (2 alternative transcripts): 
    NM_004442.6  NM_017449.3  

    Unigene Cluster for EPHB2:

    EPH receptor B2
    Hs.523329  [show with all ESTs]
    Unigene Representative Sequence: NM_004442
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374630 ENST00000400191(uc009vqj.1 uc001bge.3 uc001bgf.3 uc010odu.2)
    ENST00000374632 ENST00000374627 ENST00000465676 ENST00000490436 ENST00000544305


    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat EPHB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EPHB2 (see all 43):
    hsa-miR-4254 hsa-miR-3607-3p hsa-miR-128 hsa-miR-30d hsa-miR-548m hsa-miR-9 hsa-miR-30a hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidEPHB2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for EPHB2
    Predesigned siRNA for gene silencing in human, mouse, rat EPHB2
    Clone
    Products:
         
    OriGene clones in human, mouse for EPHB2 (see all 12)
    OriGene ORF clones in mouse, rat for EPHB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): EPHB2 (NM_004442)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHB2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for EPHB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EPHB2
      QuantiTect SYBR Green Assays in human, mouse, rat EPHB2
      QuantiFast Probe-based Assays in human, mouse, rat EPHB2

    Additional mRNA sequence: 

    AB210018.1 AF025304.1 AK298898.1 AK299701.1 BC007903.2 BC018763.1 BC041017.1 BC067861.1 
    D14717.1 D31661.1 D37827.1 HM437237.1 L36643.1 L41939.1 

    9 DOTS entries:

    DT.101982270  DT.70104571  DT.100780995  DT.95273654  DT.40108316  DT.75199320  DT.100780994  DT.91914811 
    DT.121420003 

    Selected AceView cDNA sequences (see all 135):

    AA505599 AI337308 NM_017449 BM698805 AA552367 BM013534 BC041017 AI216739 
    BM889532 BU856322 BE796053 AW162602 BM982159 BX113022 BU740470 BC067861 
    BQ925644 AA505740 CA417154 BM795617 AA570007 AA341538 AL530874 AI268257 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for EPHB2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
    SP1:                                -     -                       -                                                                     
    SP2:                                -     -                       -                                                                     
    SP3:                                -     -                                                                                             
    SP4:                                                              -                                                                     
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for EPHB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    EPHB2 expression in normal human tissues (normalized intensities)      EPHB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    EPHB2 Expression
    About this image


    EPHB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Endothelium (Cardiovascular System)
             Arterial Endothelial Cells Paired Dorsal Aorta
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Arterial Endothelial Cells Paired Dorsal Aorta
     
     Eye (Sensory Organs)
             Retina
    EPHB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EPHB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523329

    UniProtKB/Swiss-Prot: EPHB2_HUMAN, P29323
    Tissue specificity: Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially
    expressed in fetal brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including EPHB2: 
              TGFB Signaling Targets in human mouse rat
              Tumor Metastasis in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for EPHB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EPHB2
    QuantiTect SYBR Green Assays in human, mouse, rat EPHB2
    QuantiFast Probe-based Assays in human, mouse, rat EPHB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for EPHB2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ephb21 , 5 Eph receptor B21, 5 90.94(n)1
    99.49(a)1
      4 (69.00 cM)5
    138441  NM_010142.21  NP_034272.11 
     1366475395 
    chicken
    (Gallus gallus)
    Aves EPHB21 EPH receptor B2 84.64(n)
    96.07(a)
      396513  NM_206951.3  NP_996834.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    93(a)
    63(a)
    1 ↔ many
    1 ↔ many
    AAWZ02037300(1196-17044)
    GL344083.1(3312-35224)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.5062 Xenopus laevis EphB2-tyrosine kinase receptor (xEphB2) more 80.82(n)    AF026039.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ephb21 EPH receptor B2 77.65(n)
    86.78(a)
      562176  XM_001919987.3  XP_001920022.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Eph3 protein amino acid phosphorylation
    transmembrane more
    42(a)
    (best of 2)
      102C2   --


    ENSEMBL Gene Tree for EPHB2 (if available)
    TreeFam Gene Tree for EPHB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for EPHB2 gene
    EPHB12  EPHA22  EPHB32  EPHA42  EPHA52  EPHB62  EPHA62  EPHA12  
    EPHA82  EPHA32  EPHA72  EPHA102  EPHB42  
    Selected SIMAP similar genes for EPHB2 using alignment to 4 protein entries:     EPHB2_HUMAN (see all proteins) (see all similar genes):
    EPHB2 variant protein    EPHB1    EPHB3    EPHA6    EPHA3    EPHA4
    EPHA7    EPHA5    EPHA8    SRC    EPHA2    ABL1
    EPHB4    FGR    tec    EPHB6    EPHA10    FYN

    EPHB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for EPHB2 (see all 4330)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs358829521,2,,4
    C,FProstate cancer (PC)4 pathogenic123402717(+) TCAAGG/TCCAAC 4 A S mis15Minor allele frequency- T:0.01NA EU 5955
    rs1421731751,2,,4
    C,FProstate cancer (PC)4 --23446417(+) CTTTGT/CGGCCA 4 /A /V mis11Minor allele frequency- C:0.01NA 4552
    VAR_0328574
    Prostate cancer (PC)4--see VAR_0328572 M V mis40--------
    VAR_0328564
    Prostate cancer (PC)4--see VAR_0328562 H N mis40--------
    VAR_0328534
    Prostate cancer (PC)4--see VAR_0328532 R H mis40--------
    VAR_0328584
    Prostate cancer (PC)4--see VAR_0328582 I M mis40--------
    rs289363951,2,,4
    C,Fpathogenic123446500(+) AGTTCG/AACCAT 4 /N /D mis13Minor allele frequency- A:0.01NS NA EU 5945
    rs768261471,2
    C,Fother123453404(+) GAAAAA/TAAAAG 2 -- ut313Minor allele frequency- T:0.07CSA WA 122
    rs127592401,2
    C,F,H--23036794(+) ACACCT/CTTTTT 2 -- us2k1 trp31Minor allele frequency- C:0.01NS 180
    rs752619571,2
    --23037727(+) CGGCGA/GGCGCT 2 -- int10--------

    HapMap Linkage Disequilibrium report for EPHB2 (23037331 - 23241823 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for EPHB2 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1389294CNV Deletion17803354
    nsv6409CNV Insertion18451855
    nsv509036CNV Insertion20534489
    esv2538911CNV Insertion19546169
    nsv512725CNV Insertion21212237
    nsv469829CNV Loss16826518
    nsv870618CNV Loss21882294
    nsv528926CNV Loss19592680
    esv34161CNV Loss18971310
    nsv871487CNV Loss21882294

    Human Gene Mutation Database (HGMD): EPHB2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EPHB2
    DNA2.0 Custom Variant and Variant Library Synthesis for EPHB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600997   
    OMIM disorders: 603688  
    UniProtKB/Swiss-Prot: EPHB2_HUMAN, P29323
  • Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate
    cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of
    prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma,
    prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid
    cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Note=The gene represented
    in this entry may be involved in disease pathogenesis. EPHB2 mutations have been found in a prostate cancer cell
    line derived from a brain metastasis

  • Selected diseases for EPHB2 (see all 52):    About MalaCards
    prostate cancer, progression and metastasis of    prostate cancer, progression of    cancer progression/metastasis    craniofrontonasal syndrome
    prostate cancer    doxorubicin induced cardiomyopathy    pathological gambling    familial colorectal cancer
    waldenstrom macroglobulinemia    macroglobulinemia    teratocarcinoma    colorectal cancer
    neuroendocrine carcinoma    adenoiditis    small cell carcinoma    adenoid cystic carcinoma
    cleft lip    prostatitis    wilms tumor    lung cancer

    2 diseases from the University of Copenhagen DISEASES database for EPHB2:
    Colorectal cancer     Craniofrontonasal syndrome

    EPHB2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for EPHB2 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 31.3 32 16166419 (5), 11166921 (2), 20046096 (2), 8033077 (2) (see all 15)
    colorectal tumors 30.3 3 11166921 (1), 16740153 (1), 19366806 (1)
    teratocarcinoma 29.7 1 8589679 (1)
    glioblastoma 27.1 5 15126357 (4), 16049340 (1)
    adenoma 23 7 16033834 (3), 16272170 (2), 17708598 (1), 16740153 (1)
    necrosis 19.6 1 18328147 (1)
    colon cancer 17.7 9 16272170 (2), 19621336 (2), 11166921 (1), 18281782 (1) (see all 5)
    colorectal cancer 16.9 23 19621336 (5), 18695888 (4), 16033834 (4), 19366806 (3) (see all 8)
    cancer 16.7 17 16166419 (3), 16033834 (3), 17249693 (2), 11166921 (1) (see all 8)
    colon tumor 14.6 2 11166921 (1), 16740153 (1)

    Genetic Association Database (GAD): EPHB2
    Human Genome Epidemiology (HuGE) Navigator: EPHB2 (11 documents)

    Export disorders for EPHB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for EPHB2 gene, integrated from 10 sources (see all 265):
    (articles sorted by number of sources associating them with EPHB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history. (PubMed id 16155194)1, 2, 4, 9 Kittles R.A....Carpten J.D. (J. Med. Genet. 2006)
    2. eek and erk, new members of the eph subclass of receptor protein- tyrosine kinases. (PubMed id 1648701)1, 2, 3, 9 Chan J. and Watt V.M. (Oncogene 1991)
    3. Molecular characterization and chromosomal localization of DRT (EPHT3): a developmentally regulated human protein-tyrosine kinase gene of the EPH family. (PubMed id 8589679)1, 2, 9 Ikegaki N.... Pleasure D.E. (Hum. Mol. Genet. 1995)
    4. A variant transcript encoding an isoform of the human protein tyrosine kinase EPHB2 is generated by alternative splicing and alternative use of polyadenylation signals. (PubMed id 9696046)1, 2, 9 Tang X.X.... Ikegaki N. (Oncogene 1998)
    5. Overexpression of ERK, an EPH family receptor protein tyrosine kinase, in various human tumors. (PubMed id 8033077)1, 2, 9 Kiyokawa E.... Kino I. (Cancer Res. 1994)
    6. EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis. (PubMed id 16740153)1, 4, 9 Kokko A....Aaltonen L.A. (BMC Cancer 2006)
    7. Identification of protein-tyrosine kinase genes preferentially expressed in embryo stomach and gastric cancer. (PubMed id 7688222)1, 2, 9 Iwase T.... Kino I. (Biochem. Biophys. Res. Commun. 1993)
    8. Oligomeric structure of the human EphB2 receptor SAM domain. (PubMed id 9933164)1, 2, 9 Thanos C.D.... Bowie J.U. (Science 1999)
    9. cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. (PubMed id 7898931)1, 2, 9 Fox G.M.... Welcher A.A. (Oncogene 1995)
    10. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2048 HGNC: 3393 AceView: EPHB2 Ensembl:ENSG00000133216 euGenes: HUgn2048
    ECgene: EPHB2 Kegg: 2048 H-InvDB: EPHB2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for EPHB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EPHB2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for EPHB2 gene:
    Search GeneIP for patents involving EPHB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of EPHB2
     Browse Small Molecules at EMD Millipore
     EMD Millipore Purified and/or Recombinant EPHB2 Protein
     
     EMD Millipore genomic analysis products

      
     Antibodies for EPHB2 (EphB2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for EPHB2 (EphB2)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for EPHB2 (EphB2)  
     OriGene Antibodies for EPHB2   OriGene RNAi products in human, mouse, rat for EPHB2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for EPHB2  
     OriGene qSTAR qPCR primer pairs in human, mouse for EPHB2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for EPHB2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for EPHB2   OriGene Custom Protein Services for EPHB2  

     
     
     Block miRNA regulation of human, mouse, rat EPHB2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing EPHB2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EPHB2 Predesigned siRNA for gene silencing in human, mouse, rat EPHB2
     QuantiFast Probe-based Assays in human, mouse, rat EPHB2 QuantiTect SYBR Green Assays in human, mouse, rat EPHB2
     PCR Arrays including human, mouse, rat EPHB2 Search Chromatin IP Primers for EPHB2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EPHB2  GeneGlobe Interaction Network for EPHB2
     Regulatory tfbs in EPHB2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for EPHB2 GenScript cDNA clones with any tag delivered in your preferred vector for EPHB2
     GenScript EPHB2-Activity-based Kinase Assay for Compound Screening GenScript Custom overexpressing Cell Line Services for EPHB2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for EPHB2
     Browse Sino Biological Proteins
     Cell Lysates for EPHB2
     cDNA Clones for EPHB2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for EPHB2
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     EPHB2 antibodies
     EPHB2 proteins
     Antibodies for EPHB2
     See all of Abcam's Antibodies, Kits and Proteins for EPHB2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for EPHB2
     Antibodies for EPHB2
     ELISAs for EPHB2
     CLIAs for EPHB2



     Browse ESI BIO Cell Lines and PureStem Progenitors for EPHB2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHB2
     SwitchGear 3'UTR luciferase reporter plasmids for EPHB2
     Browse SwitchGear Promoter luciferase reporter plasmids for EPHB2
     ThermoFisher Antibody for EPHB2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHB2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EPHB2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for EPHB2
     LSBio Antibodies in human, mouse, rat for EPHB2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      EPHB2 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4