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Aliases for EPHB2 Gene

Aliases for EPHB2 Gene

  • EPH Receptor B2 2 3 5
  • Developmentally-Regulated Eph-Related Tyrosine Kinase 3 4
  • Tyrosine-Protein Kinase Receptor EPH-3 3 4
  • Renal Carcinoma Antigen NY-REN-47 3 4
  • Tyrosine-Protein Kinase TYRO5 3 4
  • EPH-Like Kinase 5 3 4
  • EC 2.7.10.1 4 61
  • Tyro5 3 4
  • EPHT3 3 4
  • Hek5 3 4
  • DRT 3 4
  • ERK 3 4
  • EK5 3 4
  • Protein-Tyrosine Kinase HEK5 3
  • Elk-Related Tyrosine Kinase 3
  • ELK-Related Tyrosine Kinase 4
  • Ephrin Type-B Receptor 2 3
  • Eph Tyrosine Kinase 3 3
  • EPH Tyrosine Kinase 3 4
  • EC 2.7.10 61
  • EphB2 2
  • EPTH3 4
  • CAPB 3
  • PCBC 3

External Ids for EPHB2 Gene

Previous HGNC Symbols for EPHB2 Gene

  • DRT
  • ERK
  • EPHT3

Previous GeneCards Identifiers for EPHB2 Gene

  • GC01P022677
  • GC01P022143
  • GC01P022506
  • GC01P022782
  • GC01P022910
  • GC01P023037
  • GC01P021351

Summaries for EPHB2 Gene

Entrez Gene Summary for EPHB2 Gene

  • This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

GeneCards Summary for EPHB2 Gene

EPHB2 (EPH Receptor B2) is a Protein Coding gene. Diseases associated with EPHB2 include Prostate Cancer/Brain Cancer Susceptibility, Somatic and Prostate Cancer. Among its related pathways are Activation of cAMP-Dependent PKA and GPCR Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is EPHB1.

UniProtKB/Swiss-Prot for EPHB2 Gene

  • Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.

Tocris Summary for EPHB2 Gene

  • Eph receptors are the largest family of receptor tyrosine kinases (RTKs) and are divided into two subclasses, EphA and EphB. Originally identified as mediators of axon guidance, Eph receptors are implicated in many processes, particularly cancer development and progression.

Gene Wiki entry for EPHB2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHB2 Gene

Genomics for EPHB2 Gene

Regulatory Elements for EPHB2 Gene

Enhancers for EPHB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F022814 1.2 ENCODE 25.6 +104.8 104769 2.1 BCOR ESRRA RFX1 ZMYM3 MNT ZNF121 ADNP ZNF341 ZBTB33 KDM1A EPHB2 ENSG00000225952 GC01M022785
GH01F022807 0.8 Ensembl ENCODE 25.1 +98.0 98046 1.8 ZNF263 HLF ZMYM3 SIN3A NR2F2 ZNF121 SMARCA4 HMBOX1 FOS MAFK EPHB2 ENSG00000225952 GC01M022785
GH01F022824 0.9 Ensembl ENCODE 22.6 +118.2 118164 8.4 HDAC1 TBP NFXL1 RAD21 BRCA1 YY1 RCOR1 FOS EGR2 SMARCA5 EPHB2 ZNF436-AS1 LINC01355 PITHD1 ENSG00000225952 GC01M022785
GH01F022794 0.9 Ensembl ENCODE 20 +84.1 84106 1.2 ZNF121 BCOR KDM1A ZBTB40 EPHB2 GC01M022785 ENSG00000225952
GH01F022795 0.2 ENCODE 13.2 +85.4 85420 1.3 BCOR ZMYM3 ZBTB40 NR2F2 SCRT2 HMBOX1 PRDM10 KDM1A EPHB2 GC01M022785 ENSG00000225952
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around EPHB2 on UCSC Golden Path with GeneCards custom track

Promoters for EPHB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001742609 230 2001 ZNF121 GLIS2 EGR2 ZNF362 CEBPB POLR2H SMARCA4 ZBTB26 ZBTB17 TAF1

Genomic Location for EPHB2 Gene

Chromosome:
1
Start:
22,710,770 bp from pter
End:
22,921,500 bp from pter
Size:
210,731 bases
Orientation:
Plus strand

Genomic View for EPHB2 Gene

Genes around EPHB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPHB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPHB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPHB2 Gene

Proteins for EPHB2 Gene

  • Protein details for EPHB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29323-EPHB2_HUMAN
    Recommended name:
    Ephrin type-B receptor 2
    Protein Accession:
    P29323
    Secondary Accessions:
    • O43477
    • Q5T0U6
    • Q5T0U7
    • Q5T0U8

    Protein attributes for EPHB2 Gene

    Size:
    1055 amino acids
    Molecular mass:
    117493 Da
    Quaternary structure:
    • Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain) (By similarity). Interacts with ARHGEF15; mediates ARHGEF15 phosphorylation, ubiquitination and degradation by the proteasome. Interacts with AQP1; involved in endolymph production in the inner ear.

    Three dimensional structures from OCA and Proteopedia for EPHB2 Gene

    Alternative splice isoforms for EPHB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPHB2 Gene

Selected DME Specific Peptides for EPHB2 Gene

P29323:
  • MNYVHRDLAARN
  • QLVGMLRG
  • RDLAARN
  • GAGEFGEV
  • RWTAPEAI
  • WSYGIVMWEVMS
  • CKETFNL
  • RKFTSASD
  • RRGFERADSEYTDKLQHYTSGH
  • PPSGWEE
  • TTNQAAPS
  • GYTEKQRRDFL
  • FQETLSGAESTSLVA
  • YIDPFTYEDPNEAV
  • SDVWSYGI
  • DTIAADE
  • YVHRDLAARNILVN
  • SDPTYTS
  • TYQVCNV
  • GERPYWD
  • YRLPPPMDCP
  • PRQLGLT
  • LEGVVTKS
  • NLVCKVSDFGLSR
  • WEVMSYGERPY
  • PVMIITE
  • LDSFLRQ
  • LDKMIRNP
  • QNNWLRT
  • QPDQPNGVILDY
  • GWEEVSGYDE
  • CNGDGEW
  • REFAKEID
  • TEFMENG
  • GMLRGIAAGM
  • GFYLAFQD
  • DGQFTVIQL
  • EASIMGQF
  • IRNPNSLK
  • QLMLDCW
  • TATAELGW
  • LMLDCWQK
  • LAGHQKKIL
  • SYGERPYW
  • QVRARTVAGYGRYS
  • LKLPGKR
  • AEEVDVPIK
  • YSGKMYFQT

Post-translational modifications for EPHB2 Gene

  • Glycosylation at Asn 265, Asn 336, Asn 428, and Asn 482
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EPHB2 (EphB2)

Domains & Families for EPHB2 Gene

Suggested Antigen Peptide Sequences for EPHB2 Gene

Graphical View of Domain Structure for InterPro Entry

P29323

UniProtKB/Swiss-Prot:

EPHB2_HUMAN :
  • Contains 1 Eph LBD (Eph ligand-binding) domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Domain:
  • Contains 1 Eph LBD (Eph ligand-binding) domain.
  • Contains 2 fibronectin type-III domains.
  • Contains 1 protein kinase domain.
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
genes like me logo Genes that share domains with EPHB2: view

Function for EPHB2 Gene

Molecular function for EPHB2 Gene

GENATLAS Biochemistry:
EPH-related tyrosine kinase receptor,binding ephrins B,expressed in projecting neurons and their target fields,involved in short-range contact-mediated axonal guidance,developmentally regulated,expressed in brain,and other tissues,likely involved in neurogenesis and oncogenesis (neuroblastoma,SCLC),phosphorylating and interacting with RRAS to control integrin activity
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.

Enzyme Numbers (IUBMB) for EPHB2 Gene

Gene Ontology (GO) - Molecular Function for EPHB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA,ISS --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IEA --
GO:0004872 receptor activity IEA --
GO:0005003 ephrin receptor activity IEA --
genes like me logo Genes that share ontologies with EPHB2: view
genes like me logo Genes that share phenotypes with EPHB2: view

Human Phenotype Ontology for EPHB2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for EPHB2 Gene

MGI Knock Outs for EPHB2:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for EPHB2 Gene

Localization for EPHB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHB2 Gene

Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPHB2 Gene COMPARTMENTS Subcellular localization image for EPHB2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 4
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for EPHB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,ISS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with EPHB2: view

Pathways & Interactions for EPHB2 Gene

genes like me logo Genes that share pathways with EPHB2: view

SIGNOR curated interactions for EPHB2 Gene

Activates:
Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for EPHB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0001525 angiogenesis IEA,ISS --
GO:0001655 urogenital system development IEA,ISS --
GO:0006468 protein phosphorylation IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA --
genes like me logo Genes that share ontologies with EPHB2: view

Drugs & Compounds for EPHB2 Gene

(10) Drugs for EPHB2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Phosphoaminophosphonic Acid-Adenylate Ester Experimental Pharma Target 0

(8) Additional Compounds for EPHB2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with EPHB2: view

Transcripts for EPHB2 Gene

Unigene Clusters for EPHB2 Gene

EPH receptor B2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EPHB2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - - -
SP2: - - -
SP3: - -
SP4: -
SP5:

Relevant External Links for EPHB2 Gene

GeneLoc Exon Structure for
EPHB2
ECgene alternative splicing isoforms for
EPHB2

Expression for EPHB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EPHB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EPHB2 Gene

This gene is overexpressed in Colon - Transverse (x6.7).

Protein differential expression in normal tissues from HIPED for EPHB2 Gene

This gene is overexpressed in Fetal Brain (37.6) and Ovary (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EPHB2 Gene



Protein tissue co-expression partners for EPHB2 Gene

NURSA nuclear receptor signaling pathways regulating expression of EPHB2 Gene:

EPHB2

SOURCE GeneReport for Unigene cluster for EPHB2 Gene:

Hs.523329

mRNA Expression by UniProt/SwissProt for EPHB2 Gene:

P29323-EPHB2_HUMAN
Tissue specificity: Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.
genes like me logo Genes that share expression patterns with EPHB2: view

Primer Products

Orthologs for EPHB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for EPHB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EPHB2 34 35
  • 99.65 (n)
oppossum
(Monodelphis domestica)
Mammalia EPHB2 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EPHB2 34 35
  • 93.46 (n)
cow
(Bos Taurus)
Mammalia EPHB2 34 35
  • 92.52 (n)
rat
(Rattus norvegicus)
Mammalia Ephb2 34
  • 91.21 (n)
mouse
(Mus musculus)
Mammalia Ephb2 34 16 35
  • 90.94 (n)
chicken
(Gallus gallus)
Aves EPHB2 34 35
  • 84.64 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 93 (a)
OneToMany
-- 35
  • 63 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.506 34
zebrafish
(Danio rerio)
Actinopterygii ephb2b 35
  • 88 (a)
OneToMany
ephb2a 35
  • 83 (a)
OneToMany
ephb2 34
  • 77.65 (n)
fruit fly
(Drosophila melanogaster)
Insecta Eph 36 35
  • 42 (a)
hop 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
CSA.7809 35
  • 41 (a)
ManyToMany
CSA.1664 35
  • 40 (a)
ManyToMany
Species where no ortholog for EPHB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EPHB2 Gene

ENSEMBL:
Gene Tree for EPHB2 (if available)
TreeFam:
Gene Tree for EPHB2 (if available)

Paralogs for EPHB2 Gene

Variants for EPHB2 Gene

Sequence variations from dbSNP and Humsavar for EPHB2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs142173175 Prostate cancer (PC) [MIM:176807] 22,906,770(+) CTTTG(C/T)GGCCA reference, missense
rs201754821 Prostate cancer (PC) [MIM:176807] 22,784,861(+) CCCCC(A/G)CATCA reference, missense
rs35882952 Prostate cancer (PC) [MIM:176807], Pathogenic 22,863,060(+) TCAAG(C/G/T)CCAAC downstream-variant-500B, reference, missense
rs372653137 Prostate cancer (PC) [MIM:176807] 22,910,526(+) ACAAG(A/G)TGATC reference, missense
VAR_032856 Prostate cancer (PC) [MIM:176807]

Structural Variations from Database of Genomic Variants (DGV) for EPHB2 Gene

Variant ID Type Subtype PubMed ID
esv1389294 CNV deletion 17803354
esv2538911 CNV insertion 19546169
esv34161 CNV loss 18971310
esv3577785 CNV loss 25503493
nsv1012432 CNV loss 25217958
nsv1075734 CNV deletion 25765185
nsv1116592 CNV tandem duplication 24896259
nsv1118106 CNV deletion 24896259
nsv469829 CNV loss 16826518
nsv476503 CNV novel sequence insertion 20440878
nsv481144 CNV novel sequence insertion 20440878
nsv509036 CNV insertion 20534489
nsv512725 CNV insertion 21212237
nsv528926 CNV loss 19592680
nsv6409 CNV insertion 18451855

Variation tolerance for EPHB2 Gene

Residual Variation Intolerance Score: 2.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EPHB2 Gene

Human Gene Mutation Database (HGMD)
EPHB2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EPHB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPHB2 Gene

Disorders for EPHB2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for EPHB2 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer/brain cancer susceptibility, somatic
  • prostate cancer/brain cancer susceptibility
prostate cancer
  • prostate cancer, hereditary, 5
sclerosing liposarcoma
doxorubicin induced cardiomyopathy
transitional cell carcinoma
  • transitional carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search EPHB2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

EPHB2_HUMAN
  • Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269 PubMed:15300251, ECO:0000269 PubMed:16155194}. Note=The gene represented in this entry may be involved in disease pathogenesis. EPHB2 mutations have been found in a prostate cancer cell line derived from a brain metastasis.

Relevant External Links for EPHB2

Genetic Association Database (GAD)
EPHB2
Human Genome Epidemiology (HuGE) Navigator
EPHB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EPHB2
genes like me logo Genes that share disorders with EPHB2: view

No data available for Genatlas for EPHB2 Gene

Publications for EPHB2 Gene

  1. A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history. (PMID: 16155194) Kittles R.A. … Carpten J.D. (J. Med. Genet. 2006) 3 4 22 46 64
  2. eek and erk, new members of the eph subclass of receptor protein- tyrosine kinases. (PMID: 1648701) Chan J. … Watt V.M. (Oncogene 1991) 2 3 4 22 64
  3. EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis. (PMID: 16740153) Kokko A. … Aaltonen L.A. (BMC Cancer 2006) 3 22 46 64
  4. Oligomeric structure of the human EphB2 receptor SAM domain. (PMID: 9933164) Thanos C.D. … Bowie J.U. (Science 1999) 3 4 22 64
  5. A variant transcript encoding an isoform of the human protein tyrosine kinase EPHB2 is generated by alternative splicing and alternative use of polyadenylation signals. (PMID: 9696046) Tang X.X. … Ikegaki N. (Oncogene 1998) 3 4 22 64

Products for EPHB2 Gene

Sources for EPHB2 Gene

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