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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EPHB2 Gene

protein-coding   GIFtS: 73
GCID: GC01P023037

EPH receptor B2

(Previous name: EphB2 )
(Previous symbols: DRT, ERK, EPHT3)
 Explore 61 diseases affiliated with
EPHB2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for EPHB2    

Aliases
for EPHB2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
EPH Receptor B21 2     EPH-Like Kinase 52 3
DRT1 2 3 5     EC 2.7.10.13 8
EPHT31 2 3 5     CAPB2 5
ERK1 2 3 5     PCBC2 5
Hek51 2     EphB21
Tyro51 2     Ephrin Type-B Receptor 22
Developmentally-Regulated Eph-Related Tyrosine Kinase2 3     Protein-Tyrosine Kinase HEK52
ELK-Related Tyrosine Kinase2 3     EPTH33
EPH Tyrosine Kinase 32 3     HEK53
Renal Carcinoma Antigen NY-REN-472 3     TYRO53
Tyrosine-Protein Kinase Receptor EPH-32 3     HEK53
Tyrosine-Protein Kinase TYRO52 3     EC 2.7.108
EK52 3     

External Ids:    HGNC: 33931   Entrez Gene: 20482   Ensembl: ENSG000001332167   OMIM: 6009975   UniProtKB: P293233   

Export aliases for EPHB2 gene to outside databases

Previous GC identifers: GC01P022677 GC01P022143 GC01P022506 GC01P022782 GC01P022910 GC01P021351


Summaries
for EPHB2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for EPHB2:
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous
system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class,
which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are
transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their
extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make
up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor
for ephrin-B family members. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: EPHB2_HUMAN, P29323
Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent
cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream
of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is
referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of
commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex.
Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell
axons to the optic disk. Beside axon guidance, also regulates dendritic spines development and maturation and
stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative
regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate
development and in inner ear development through regulation of endolymph production. Forward and reverse signaling
through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the
cloaca. May function as a tumor suppressor

Gene Wiki entry for EPHB2 (EPH receptor B2)


Genomic Views
for EPHB2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EPHB2 gene promoter:
         CREB   ATF-2   deltaCREB   STAT3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for EPHB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPHB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.1-p35   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.1-p35

EPHB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHB2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P023037:  view genomic region     (about GC identifiers)

Start:
 23,037,331 bp from pter      End:
 23,241,823 bp from pter
Size:
 204,493 bases      Orientation:
 plus strand

Proteins
for EPHB2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: EPHB2_HUMAN, P29323 (See protein sequence)
Recommended Name: Ephrin type-B receptor 2 precursor  
Size: 1055 amino acids; 117493 Da
Subunit: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor
dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via PDZ-binding
motif) with GRIP1 and PICK1 (via PDZ domain) (By similarity). Interacts with ARHGEF15; mediates ARHGEF15
phosphorylation, ubiquitination and degradation by the proteasome. Interacts with AQP1; involved in endolymph
production in the inner ear
Subcellular location: Cell membrane; Single-pass type I membrane protein. Cell projection, axon (By similarity). Cell
projection, dendrite (By similarity)
3 PDB 3D structures from and Proteopedia for EPHB2:
1B4F (3D)        1F0M (3D)        2QBX (3D)    
Secondary accessions: O43477 Q5T0U6 Q5T0U7 Q5T0U8
Alternative splicing: 3 isoforms:  P29323-1   P29323-2   P29323-3   (No experimental confirmation available. Contains a phosphoserine at position 984)

Explore the universe of human proteins at neXtProt for EPHB2: NX_P29323

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P29323

    • 4/48 DME Specific Peptides for EPHB2 (P29323) (see all 48)
     PVMIITE  RDLAARN  LDSFLRQ  QNNWLRT 

    EPHB2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_004433.2  NP_059145.2  

    ENSEMBL proteins: 
     ENSP00000363761   ENSP00000383053   ENSP00000363763   ENSP00000363758   ENSP00000444174  
    Reactome Protein details: P29323
    Human Recombinant Protein Products: 
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    Novus Biologicals EPHB2 Proteins
    Sino Biological Recombinant Protein for EPHB2
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for EPHB2

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane ISS--
    GO:0016021integral to membrane ----
    GO:0030424axon ISS--
    GO:0030425dendrite ISS--
    GO:0043025neuronal cell body IEA--


    EPHB2 for ontologies           About GeneDecksing



    EPHB2 Antibody Products: 
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    Assay Products for EPHB2: 
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for EPHB2

    Protein Domains /
    Families
    for EPHB2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    EPHB2 for domains           About GeneDecksing

    5/17 InterPro domains/families (see all 17):
     IPR017441 Protein_kinase_ATP_BS
     IPR003961 Fibronectin_type3
     IPR021129 SAM_type1
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P29323

    ProtoNet protein and cluster: P29323

    5 Blocks protein families:
    IPB001090 Ephrin receptor
    IPB001426 Receptor tyrosine kinase
    IPB001660 Sterile alpha motif SAM
    IPB003962 Fibronectin type III repeat signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EPHB2_HUMAN, P29323
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Function
    for EPHB2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: EPHB2_HUMAN, P29323
    Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent
    cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream
    of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is
    referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of
    commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex.
    Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell
    axons to the optic disk. Beside axon guidance, also regulates dendritic spines development and maturation and
    stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative
    regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate
    development and in inner ear development through regulation of endolymph production. Forward and reverse signaling
    through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the
    cloaca. May function as a tumor suppressor
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for EPHB2:
    EPH-related tyrosine kinase receptor,binding ephrins B,expressed in projecting neurons and their target fields,involved
    in short-range contact-mediated axonal guidance,developmentally regulated,expressed in brain,and other tissues,likely
    involved in neurogenesis and oncogenesis (neuroblastoma,SCLC),phosphorylating and interacting with RRAS to control
    integrin activity

    Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EPHB2
    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate EPHB2 (see all 43):
    hsa-miR-4254 hsa-miR-3607-3p hsa-miR-128 hsa-miR-30d hsa-miR-548m hsa-miR-9 hsa-miR-30a hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmid: EPHB2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EPHB2 (see all 7)
    OriGene shRNA RFP: EPHB2
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPHB2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for EPHB2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EPHB2 (see all 5)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): EPHB2 (NM_004442)
    Sino Biological Human cDNA Clone for EPHB2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHB2 

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    In Situ Assay
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    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004713protein tyrosine kinase activity ISS--
    GO:0004872receptor activity ----
    GO:0005003ephrin receptor activity ----
    GO:0005005transmembrane-ephrin receptor activity TAS8589679
    GO:0005102receptor binding IEA--


    EPHB2 for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for EPHB2:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased S DNA content  Increased cell number in G2M,  
     Upregulation of Wnt/beta-caten  Weaker migration 

    Animal Models:
         Mouse knock-out Ephb2tm1Paw for EPHB2
         12 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Ephb2):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size  hearing/vestibular/ear  mortality/aging  nervous system  renal/urinary system 
     reproductive system  vision/eye 

    EPHB2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for EPHB2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    		P2Y Receptor Signaling0.38
    2Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    3Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		14-3-3 Induced Intracellular Signaling0.59
    		GSK3 Signaling0.61
    		eNOS Signaling0.48
    4Axon guidance
    		Axon guidance1.00
    		L1CAM interactions0.39
    		Developmental Biology0.69
    5Actin Nucleation by ARP-WASP Complex
    		Actin Nucleation by ARP-WASP Complex1.00
    		CDC42 Pathway0.34
    		Actin Nucleation and Branching0.66

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for EPHB2
        Cytoskeleton remodeling Reverse signaling by ephrin B
    Cell adhesion Ephrins signaling

    5/31 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EPHB2 (see all 31)
        MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Ephrin-Eph Signaling

    2 GeneGo (Thomson Reuters) Pathways for EPHB2
        Cytoskeleton remodeling Reverse signaling by ephrin B
    Cell adhesion Ephrins signaling

    5/6 BioSystems Pathways for EPHB2 (see all 6) 
        Keap1-Nrf2 Pathway
    NLR proteins
    EPHB forward signaling
    Ephrin B reverse signaling
    Syndecan-2-mediated signaling events

    3        Reactome Pathways for EPHB2
        L1CAM interactions
    Developmental Biology
    Axon guidance


    1         Kegg Pathway  (Kegg details for EPHB2):
        Axon guidance


    EPHB2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EPHB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/73 Interacting proteins for EPHB2 (P293232, 3 ENSP000003637634) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUP153P497902, 3, ENSP000002620774MINT-4300391 MINT-4300355 I2D: score=1 STRING: ENSP00000262077
    MLLT4P551962, 3, ENSP000003836234MINT-58184 I2D: score=5 STRING: ENSP00000383623
    EFNB2P527993, ENSP000002453234I2D: score=5 STRING: ENSP00000245323
    ABL1P005193, ENSP000003614234I2D: score=3 STRING: ENSP00000361423
    EFNA5P528033, ENSP000003287774I2D: score=3 STRING: ENSP00000328777
    About this table

    Gene Ontology (GO): 5/29 biological process terms (GO ID links to tree view) (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0001525angiogenesis ISS--
    GO:0001655urogenital system development ISS--
    GO:0006468protein phosphorylation TAS--
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway ----


    EPHB2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for EPHB2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EPHB2 for compounds           About GeneDecksing

    EMD Millipore small molecules for EPHB2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EPHB2

    2 HMDB Compounds for EPHB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 DrugBank Compound for EPHB2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target--10592235

    10/15 Novoseek chemical compound relationships for EPHB2 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 73.7 66 9233798 (3), 9864179 (3), 11494128 (3), 10378896 (3) (see all 40)
    pd 98,059 46.9 5 10754327 (1), 20046096 (1), 15245433 (1), 9864179 (1) (see all 5)
    n-formylmethionyl-leucylphenylalanine 44.9 2 18328147 (1), 10378896 (1)
    sb 203580 40.4 1 10378896 (1)
    phosphatidylinositol 30.8 4 18091748 (1), 17763432 (1), 12519307 (1), 15821731 (1)
    fmlp 10.2 6 10378896 (4), 12954601 (1)
    superoxide 8.76 3 18328147 (1), 10378896 (1)
    serine 3.76 3 12731668 (1), 11583608 (1)
    lysine 0 1 10391888 (1)
    phosphoinositide 0 1 10754327 (1)

    Search CenterWatch for drugs/clinical trials and news about EPHB2 

    Transcripts
    for EPHB2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for EPHB2 gene (2 alternative transcripts): 
    NM_004442.6  NM_017449.3  

    Unigene Cluster for EPHB2:

    EPH receptor B2
    Hs.523329  [show with all ESTs]
    Unigene Representative Sequence: NM_004442
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374630 ENST00000400191(uc009vqj.1 uc001bge.3 uc001bgf.3 uc010odu.2)
    ENST00000374632 ENST00000374627 ENST00000465676 ENST00000490436 ENST00000544305


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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EPHB2
    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate EPHB2 (see all 43):
    hsa-miR-4254 hsa-miR-3607-3p hsa-miR-128 hsa-miR-30d hsa-miR-548m hsa-miR-9 hsa-miR-30a hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmid: EPHB2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EPHB2 (see all 7)
    OriGene shRNA RFP: EPHB2
    OriGene siRNA: EPHB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPHB2
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): EPHB2 (NM_004442)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHB2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPHB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPHB2

    Additional cDNA sequence: 

    AB210018.1 AF025304.1 AK298898.1 AK299701.1 BC007903.2 BC018763.1 BC041017.1 BC067861.1 
    D14717.1 D31661.1 D37827.1 HM437237.1 L36643.1 L41939.1 

    9 DOTS entries:

    DT.101982270  DT.70104571  DT.100780995  DT.95273654  DT.40108316  DT.75199320  DT.100780994  DT.91914811 
    DT.121420003 

    24/135 AceView cDNA sequences (see all 135):

    AA552367 BM889532 AI216739 BM698805 AI337308 NM_017449 AA505599 BU740470 
    BM982159 CA417154 BM795617 AW162602 BU855738 BC067861 BQ925644 AI268257 
    AL530874 AA341538 BM679304 AU119907 AA570007 BQ641281 AA502262 AA505740 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for EPHB2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
    SP1:                                -     -                       -                                                                     
    SP2:                                -     -                       -                                                                     
    SP3:                                -     -                                                                                             
    SP4:                                                              -                                                                     
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for EPHB2

    Expression
    for EPHB2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EPHB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    EPHB2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Lateral Plate MesodermPaired Dorsal AortaArterial endothelial cellsEndothelium
    BrainHypothalamusBrain
    BrainThalamusBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeDiencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    Primitive gut tube-like cells (A scalable, suspensi...)

    See EPHB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EPHB2

    SOURCE GeneReport for Unigene cluster: Hs.523329

    UniProtKB/Swiss-Prot: EPHB2_HUMAN, P29323
    Tissue specificity: Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed
    in fetal brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including EPHB2: 
              TGFB Signaling Targets in human mouse rat
              Tumor Metastasis in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EPHB2
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    In Situ
    Assay Products:     
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    Orthologs
    for EPHB2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for EPHB2 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves EPHB21 EPH receptor B2 84.63(n)
    96.01(a)    		   396513  NM_206951.1  NP_996834.1 
    lizard
    (Anolis carolinensis)    		 Reptilia EPHB26
    		 --
    		 93(a)
    		 1 ↔ 1
    		 AAWZ02037300(1206-17044)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.5062 Xenopus laevis EphB2-tyrosine kinase receptor (xEphB2) more 80.82(n)    AF026039.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ephb21 EPH receptor B2 77.74(n)
    86.92(a)    		   562176  XM_001919987.2  XP_001920022.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Eph3 protein amino acid phosphorylation
    transmembrane more    		 42(a)
    (best of 2)    		   102C2   --
    worm
    (Caenorhabditis elegans)    		 Secernentea vab-11 Protein VAB-1 46.49(n)
    39.46(a)    		   173794  NM_062406.2  NP_494807.1 


    ENSEMBL Gene Tree for EPHB2 (if available)
    TreeFam Gene Tree for EPHB2 (if available) 

    Paralogs
    for EPHB2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EPHB2 gene
    EPHB12  EPHA22  EPHB32  EPHA42  EPHA52  EPHB62  EPHA62  EPHA12  
    EPHA82  EPHA32  EPHA72  EPHB42  EPHA102  
    18/32 SIMAP similar genes for EPHB2 using alignment to 4 protein entries:     EPHB2_HUMAN (see all proteins) (see all similar genes):
    EPHB2 variant protein    EPHB1    EPHB3    EPHA6    EPHA3    EPHA4
    EPHA7    EPHA5    EPHA8    SRC    EPHA2    ABL1
    EPHB4    FGR    tec    EPHB6    FYN    EPHA10

    EPHB2 for paralogs           About GeneDecksing



    Genomic Variants
    for EPHB2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3635 NCBI SNPs in EPHB2 are shown (see all 3635)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs358829521,2
    		C,F,pathogenic23189553(+) TCAAGG/TCCAAC 5 A S mis1 ds50015Minor allele frequency- T:0.01NA EU 5955
    rs768261471,2
    		C,F,other23240250(+) GAAAAA/TAAAAG 2 -- ut313Minor allele frequency- T:0.07CSA WA 122
    rs1855109911,2
    		--23035589(+) TAGAGC/GTGCTC 2 -- us2k10--------
    rs802314301,2
    		C,F,--23035620(+) GCCTCA/CAGATG 2 -- us2k16Minor allele frequency- C:0.06NA CSA WA EA 244
    rs114203161,2
    		C,--23035756(+) GAATCT/-TTCGT 2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs350467191,2
    		C--23035758(+) AATCTT/-TCGTT 2 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1899289621,2
    		--23035795(+) AGGAAC/TGGTAG 2 -- us2k10--------
    rs1441674741,2
    		--23035838(+) ACCCTC/GGTGAG 2 -- us2k10--------
    rs1441583901,2
    		--23035988(+) AGAGAC/TGACCC 2 -- us2k10--------
    rs1486828551,2
    		--23035989(+) GAGACC/GACCCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for EPHB2 (23037331 - 23241823 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for EPHB2
         2 CNVs: 47887 2046
         1 Indel: 97317
    Human Gene Mutation Database (HGMD): EPHB2

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for EPHB2

    Disorders / Diseases
    for EPHB2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    EPHB2 for disorders           About GeneDecksing

    OMIM gene information: 600997   
    OMIM disorders: 603688  
    UniProtKB/Swiss-Prot: EPHB2_HUMAN, P29323
  • Defects in EPHB2 may be a cause of susceptibility to prostate cancer (PC) [MIM:176807]. It is a malignancy
    • originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the
    prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients
    include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous
    cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and
    neuroendocrine carcinoma. Note=EPHB2 mutations have been found in a prostate cancer cell line derived from a brain
    metastasis

    20/61 diseases for EPHB2 (see all 61):    About MalaCards
    renal carcinoma    cancer progression/metastasis    doxorubicin induced cardiomyopathy    cleft lip/palate
    carcinoma    pathological gambling    ampulla of vater carcinoma    cleft lip
    corpus callosum    venous malformations    prostate cancer, progression and metastasis of    craniofrontonasal syndrome
    intraepithelial neoplasm    prostate cancer, progression of    prostate cancer    transitional cell carcinoma
    acute lymphoblastic leukemia    basal cell carcinoma    lymphoblastic leukemia    acute myeloid leukemia

    2 diseases from the University of Copenhagen DISEASES database for EPHB2:
    Colorectal cancer     Craniofrontonasal syndrome

    10/20 Novoseek disease relationships for EPHB2 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 31.3 32 16166419 (5), 11166921 (2), 20046096 (2), 8033077 (2) (see all 15)
    colorectal tumors 30.3 3 11166921 (1), 16740153 (1), 19366806 (1)
    teratocarcinoma 29.7 1 8589679 (1)
    glioblastoma 27.1 5 15126357 (4), 16049340 (1)
    adenoma 23 7 16033834 (3), 16272170 (2), 17708598 (1), 16740153 (1)
    necrosis 19.6 1 18328147 (1)
    colon cancer 17.7 9 16272170 (2), 19621336 (2), 11166921 (1), 18281782 (1) (see all 5)
    colorectal cancer 16.9 23 19621336 (5), 18695888 (4), 16033834 (4), 19366806 (3) (see all 8)
    cancer 16.7 17 16166419 (3), 16033834 (3), 17249693 (2), 11166921 (1) (see all 8)
    colon tumor 14.6 2 11166921 (1), 16740153 (1)

    Genetic Association Database (GAD): EPHB2
    Human Genome Epidemiology (HuGE) Navigator: EPHB2 (11 documents)

    Export disorders for EPHB2 gene to outside databases

    Publications
    for EPHB2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EPHB2 gene, integrated from 9 sources (see all 256):
    (articles sorted by number of sources associating them with EPHB2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history. (PubMed id 16155194)1, 2, 4, 9 Kittles R.A....Carpten J.D. (2006)
    2. eek and erk, new members of the eph subclass of receptor protein- tyrosine kinases. (PubMed id 1648701)1, 2, 3, 9 Chan J. and Watt V.M. (1991)
    3. Molecular characterization and chromosomal localization of DRT (EPHT3): a developmentally regulated human protein-tyrosine kinase gene of the EPH family. (PubMed id 8589679)1, 2, 9 Ikegaki N.... Pleasure D.E. (1995)
    4. A variant transcript encoding an isoform of the human protein tyrosine kinase EPHB2 is generated by alternative splicing and alternative use of polyadenylation signals. (PubMed id 9696046)1, 2, 9 Tang X.X.... Ikegaki N. (1998)
    5. Overexpression of ERK, an EPH family receptor protein tyrosine kinase, in various human tumors. (PubMed id 8033077)1, 2, 9 Kiyokawa E.... Kino I. (1994)
    6. Identification of protein-tyrosine kinase genes preferentially expressed in embryo stomach and gastric cancer. (PubMed id 7688222)1, 2, 9 Iwase T.... Kino I. (1993)
    7. Oligomeric structure of the human EphB2 receptor SAM domain. (PubMed id 9933164)1, 2, 9 Thanos C.D.... Bowie J.U. (1999)
    8. cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. (PubMed id 7898931)1, 2, 9 Fox G.M.... Welcher A.A. (1995)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    10. Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer. (PubMed id 15300251)1, 2 Huusko P.... Mousses S. (2004)

    External Searches for EPHB2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing EPHB2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2048 HGNC: 3393 AceView: EPHB2 Ensembl:ENSG00000133216 euGenes: HUgn2048
    ECgene: EPHB2 Kegg: 2048 H-InvDB: EPHB2

    Other Databases showing EPHB2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing EPHB2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EPHB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EPHB2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for EPHB2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for EPHB2 gene:
    Search GeneIP for patents involving EPHB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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