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EPHB1 Gene

protein-coding   GIFtS: 67
GCID: GC03P134316

EPH Receptor B1

(Previous name: EphB1)
(Previous symbol: EPHT2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
EPH Receptor B11 2     EC 2.7.10.13 8
EPHT21 2 3 5     EphB11
NET2 3 5     Hek62
EPH Tyrosine Kinase 22 3     Ephrin Type-B Receptor 12
Neuronally-Expressed EPH-Related Tyrosine Kinase2 3     Soluble EPHB1 Variant 12
Tyrosine-Protein Kinase Receptor EPH-22 3     HEK63
EK62 3     hEK63
ELK2 3     EC 2.7.108
EPH-Like Kinase 62 3     

External Ids:    HGNC: 33921   Entrez Gene: 20472   Ensembl: ENSG000001549287   OMIM: 6006005   UniProtKB: P547623   

Export aliases for EPHB1 gene to outside databases

Previous GC identifers: GC03M131897 GC03P135607 GC03P135795 GC03P135835 GC03P135996 GC03P131890


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EPHB1 Gene:
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the
nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A
(EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B
(EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on
the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B
ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein
encoded by this gene is a receptor for ephrin-B family members. (provided by RefSeq, Jul 2008)

GeneCards Summary for EPHB1 Gene:
EPHB1 (EPH receptor B1) is a protein-coding gene. GO annotations related to this gene include transmembrane-ephrin receptor activity and axon guidance receptor activity. An important paralog of this gene is EPHA2.

UniProtKB/Swiss-Prot: EPHB1_HUMAN, P54762
Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on
adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor
include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting
ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires
repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis,
proliferation and polarity of the hippocampus neural progenitors. Beside its role in axon guidance plays also an
important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and
synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and
adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK
signaling cascades to regulate cell migration and adhesion respectively

Gene Wiki entry for EPHB1 (EPH receptor B1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the EPHB1 gene promoter:
         SRF   Spz1   SRF (504 AA)   CUTL1   STAT5A   Nkx2-5   Arnt   AREB6   HOXA5   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEPHB1 promoter sequence
   Search Chromatin IP Primers for EPHB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EPHB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21-q23   Ensembl cytogenetic band:  3q22.2   HGNC cytogenetic band: 3q21-q23

EPHB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHB1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P134316:  view genomic region     (about GC identifiers)

Start:
134,316,643 bp from pter      End:
134,979,309 bp from pter
Size:
662,667 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EPHB1_HUMAN, P54762 (See protein sequence)
Recommended Name: Ephrin type-B receptor 1 precursor  
Size: 984 amino acids; 109885 Da
Subunit: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a
receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts
with EPHB6; transphosphorylates EPHB6 to form an active signaling complex. Interacts with PICK1 (By similarity).
Interacts (through Tyr-594) with NCK1 (via SH2 domain); activates the JUN cascade to regulate cell adhesion (By
similarity). The ligand-activated form interacts (through Tyr-928) with GRB7 and GRB10 (via SH2 domains). The
ligand-activated form interacts (residues within the catalytic domain) with GRB2 (via SH2 domain). Interacts with
GRB2, SHC1 and SRC; activates the MAPK/ERK cascade to regulate cell migration. Interacts with CBL; regulates
receptor degradation through ubiquitination. Interacts with ACP1
Sequence caution: Sequence=AAB94627.1; Type=Miscellaneous discrepancy; Note=wrong intron-exon boundaries;
Sequence=AAB94628.1; Type=Miscellaneous discrepancy; Note=wrong intron-exon boundaries; Sequence=AAD02031.1;
Type=Miscellaneous discrepancy; Note=Chimeric cDNA;
3 PDB 3D structures from and Proteopedia for EPHB1:
2DJS (3D)        2EAO (3D)        3ZFX (3D)    
Secondary accessions: A8K593 O43569 O95142 O95143 Q0VG87

Explore the universe of human proteins at neXtProt for EPHB1: NX_P54762

Explore proteomics data for EPHB1 at MOPED

Post-translational modifications: 

  • Phosphorylated. Autophosphorylation is stimulated by the ligand EFNB1. Required for interaction with SH2
    domain-containing interactors, for activation of the MAPK/ERK and JUN signaling cascades and for ubiquitination
    by CBL1
  • Ubiquitinated; (EFNB1)ligand-induced poly- and/or multi-ubiquitination by CBL is regulated by SRC and leads to
    lysosomal degradation1
  • Glycosylation2 at Asn334, Asn426, Asn480
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for EPHB1 (P54762) (see all 65)
     RDLAARN  CKETFNL  SLQLVTQ  EDLLRIG 


    See EPHB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004432.1  
    ENSEMBL proteins: 
     ENSP00000417435   ENSP00000420338   ENSP00000381097   ENSP00000419688   ENSP00000417216  
     ENSP00000418352   ENSP00000419574  

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    Novus Biologicals EPHB1 Proteins
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    Abcam antibodies for EPHB1 (P29323, P54762)
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    Search eBioscience for ELISAs for EPHB1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    EPH: EPH receptors
    SAMD: Sterile alpha motif (SAM) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: EPH receptor B1
    Ephrin receptor family
    Ephrin receptor family

    Selected InterPro protein domains (see all 17):
     IPR017441 Protein_kinase_ATP_BS
     IPR003961 Fibronectin_type3
     IPR021129 SAM_type1
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P54762

    ProtoNet protein and cluster: P54762

    5 Blocks protein domains:
    IPB001090 Ephrin receptor
    IPB001426 Receptor tyrosine kinase
    IPB001660 Sterile alpha motif SAM
    IPB003962 Fibronectin type III repeat signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EPHB1_HUMAN, P54762
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Find genes that share domains with EPHB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EPHB1_HUMAN, P54762
    Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on
    adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
    pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
    the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor
    include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting
    ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires
    repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis,
    proliferation and polarity of the hippocampus neural progenitors. Beside its role in axon guidance plays also an
    important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and
    synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and
    adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK
    signaling cascades to regulate cell migration and adhesion respectively
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for EPHB1:
    EPH-related tyrosine kinase receptor,binding ephrins B1,B2,expressed in projecting neurons and their target
    fields,involved in short-range contact-mediated axonal guidance

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0005003ephrin receptor activity ----
    GO:0005005transmembrane-ephrin receptor activity IDA18034775
    GO:0005515protein binding IPI12223469
         
    Find genes that share ontologies with EPHB1           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for EPHB1:
     Decreased substrate adherent c  Increased S DNA content  Increased cell size  Increased mitotic index 
     Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ephb1):
     cellular  nervous system  vision/eye 

    Find genes that share phenotypes with EPHB1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ephb1tm1Cmn for EPHB1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EPHB1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EPHB1

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    hsa-miR-3163 hsa-miR-16-2* hsa-miR-3617 hsa-miR-545 hsa-miR-182 hsa-miR-641 hsa-miR-129-5p hsa-miR-195*
    SwitchGear 3'UTR luciferase reporter plasmidEPHB1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: EPHB1 (NM_004441)
    Sino Biological Human cDNA Clone for EPHB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHB1
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    Addgene plasmids for EPHB1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EPHB1_HUMAN, P54762: Cell membrane; Single-pass type I membrane protein. Early endosome membrane. Cell
    projection, dendrite (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane5
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005887integral component of plasma membrane IDA18034775
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0030424axon IEA--

    Find genes that share ontologies with EPHB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EPHB1 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1EphB-EphrinB Signaling
    EphB-EphrinB Signaling0.58
    Cytoskeleton remodeling Reverse signaling by ephrin B0.34
    Ephrin-Eph Signaling0.58
    2EPHB forward signaling
    EPHB forward signaling0.30
    EphrinB-EPHB pathway0.00
    Cell adhesion Ephrins signaling0.30
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48


    Find genes that share SuperPaths with EPHB1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EPHB1 (see all 31)
        MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Ephrin-Eph Signaling

    2 Cell Signaling Technology (CST) Pathways for EPHB1
        Angiogenesis
    Tyrosine Kinases / Adaptors

    2 GeneGo (Thomson Reuters) Pathways for EPHB1
        Cytoskeleton remodeling Reverse signaling by ephrin B
    Cell adhesion Ephrins signaling

    3 BioSystems Pathways for EPHB1
        Ephrin B reverse signaling
    EPHB forward signaling
    EphrinB-EPHB pathway



    1 Kegg Pathway  (Kegg details for EPHB1):
        Axon guidance

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EPHB1
    Interactions:

        GeneGlobe Interaction Network for EPHB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EPHB1 (P547621, 2, 3 ENSP000003810974) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB7Q144511, 2, 3, ENSP000003107714EBI-80252,EBI-970191 MINT-8025824 MINT-8025809 I2D: score=2 STRING: ENSP00000310771
    NCK1P163332, 3, ENSP000002889864MINT-8037883 I2D: score=4 STRING: ENSP00000288986
    GRB10Q133221, 3, ENSP000003817934EBI-80252,EBI-80275 I2D: score=4 STRING: ENSP00000381793
    GRB2P629931, 3, ENSP000003390074EBI-80252,EBI-401755 I2D: score=4 STRING: ENSP00000339007
    EFNA5P528033, ENSP000003287774I2D: score=2 STRING: ENSP00000328777
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IDA9499402
    GO:0006468protein phosphorylation ----
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway ----
    GO:0007411axon guidance ISS--
    GO:0021545cranial nerve development ----

    Find genes that share ontologies with EPHB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EPHB1

    2 HMDB Compounds for EPHB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 Novoseek inferred chemical compound relationships for EPHB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 57.8 12 15107421 (2), 10669731 (2), 18034775 (2), 18931529 (1) (see all 8)
    phosphotyrosine 41.6 1 12925710 (1)



    Find genes that share compounds with EPHB1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for EPHB1 gene: 
    NM_004441.4  

    Unigene Cluster for EPHB1:

    EPH receptor B1
    Hs.116092  [show with all ESTs]
    Unigene Representative Sequence: NM_004441
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000467013 ENST00000472904 ENST00000467708 ENST00000460895 ENST00000482618
    ENST00000398015(uc010htz.2 uc011bly.2 uc003eqt.3 uc003equ.3)
    ENST00000488154 ENST00000497173 ENST00000473867 ENST00000474732 ENST00000493838
    ENST00000488992
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    hsa-miR-3163 hsa-miR-16-2* hsa-miR-3617 hsa-miR-545 hsa-miR-182 hsa-miR-641 hsa-miR-129-5p hsa-miR-195*
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      QuantiFast Probe-based Assays in human, mouse, rat EPHB1

    Additional mRNA sequence: 

    AF037333.1 AF037334.1 AK095305.1 AK291208.1 AK309741.1 BC111744.1 EU826607.1 L40636.1 

    6 DOTS entries:

    DT.309868  DT.95298728  DT.102822705  DT.120876685  DT.97780726  DT.95155441 

    Selected AceView cDNA sequences (see all 56):

    AI732312 BX479560 BM726719 AW614904 N93797 AF037333 AI418872 AI732309 
    BE504846 AI761931 CD618765 BE550340 AW204736 L40636 NM_004441 AA889073 
    BX106825 BM681502 AW340396 AI359655 AI878971 AF037334 AW197460 AI368403 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EPHB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGGGTTTA
    EPHB1 Expression
    About this image


    EPHB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             nGnG Amacrine Cells Inner Nuclear Layer
             Inner Nuclear Layer
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Thalamus
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
    EPHB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EPHB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.116092

    UniProtKB/Swiss-Prot: EPHB1_HUMAN, P54762
    Tissue specificity: Preferentially expressed in brain

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for EPHB1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ephb11 , 5 Eph receptor B11, 5 91.33(n)1
    98.88(a)1
      9 (54.15 cM)5
    2701901  NM_173447.31  NP_775623.31 
     1019221285 
    chicken
    (Gallus gallus)
    Aves EPHB11 EPH receptor B1 84.42(n)
    94.92(a)
      396177  XM_422685.4  XP_422685.4 
    lizard
    (Anolis carolinensis)
    Reptilia EPHB16
    EPH receptor B1
    93(a)
    1 ↔ 1
    3(31663931-32101219)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.10282 Xenopus laevis receptor tyrosine kinase (XEK) mRNA, more 79.07(n)    U14164.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ephb11 EPH receptor B1 76.68(n)
    87.32(a)
      100333537  XM_002660899.3  XP_002660945.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Eph1 , 3 protein amino acid phosphorylation
    transmembrane more3
    Eph receptor tyrosine kinase1
    42(a)
    (best of 2)3
    49.39(n)1
    46.9(a)1
      102C23
    438031  NM_166775.41  NP_726589.21 


    ENSEMBL Gene Tree for EPHB1 (if available)
    TreeFam Gene Tree for EPHB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EPHB1 gene
    EPHA22  EPHB32  EPHA42  EPHA52  EPHB62  EPHA62  EPHA12  EPHB22  
    EPHA82  EPHA32  EPHA72  EPHA102  EPHB42  
    Selected SIMAP similar genes for EPHB1 using alignment to 8 protein entries:     EPHB1_HUMAN (see all proteins) (see all similar genes):
    EPHB2 variant protein    EPHB2    EPHB3    EPHA3    EPHA4    EPHA7
    EPHA5    EPHA6    EPHA8    EPHA2    EPHB4    ABL1
    SRC    EPHA10    FES    FGR    EPHB6    FYN

    Find genes that share paralogs with EPHB1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EPHB1 (see all 9540)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0421694
    A gastric adenocarcinoma sample4--see VAR_0421692 R Q mis40--------
    VAR_0421684
    A gastric adenocarcinoma sample4--see VAR_0421682 I V mis40--------
    VAR_0421674
    An ovarian undifferentiated carcinoma sample4--see VAR_0421672 S T mis40--------
    rs1137964871,2
    F--134512261(+) TGGCTG/AGGGGT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1884939961,2
    --134512397(+) CAAGAC/TGGGTA 1 -- us2k10--------
    rs124875661,2
    C,F,H--134512481(+) CTGACG/AGTGCA 1 -- us2k1 tfbs34Minor allele frequency- A:0.13WA CSA EA 242
    rs1413342111,2
    --134512558(+) ACGACA/GCAGCT 1 -- us2k10--------
    rs2007519081,2
    C--134512663(+) GGGGTA/GGGAGG 1 -- us2k10--------
    rs49895411,2
    C--134512680(-) CCTCCG/TCCCCT 1 -- us2k1 trp31Minor allele frequency- T:0.50WA 2
    rs1469879051,2
    C--134512680(+) GGGGA-/GGGGC 
            
    GGAGG
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for EPHB1 (134316643 - 134566643 bp, first 250kb of EPHB1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for EPHB1 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv991539CNV Deletion20482838
    esv2660214CNV Deletion23128226
    esv2677066CNV Deletion23128226
    nsv436394CNV Deletion17901297
    esv2490314CNV Deletion19546169
    esv2309200CNV Deletion18987734
    esv2725955CNV Deletion23290073
    esv2663866CNV Deletion23128226
    esv2421444CNV Deletion20811451
    nsv508956CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600600    OMIM disorders: --


    Find genes that share disorders with EPHB1           About GenesLikeMe

    2 Novoseek inferred disease relationships for EPHB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 0 2 18424888 (2)
    tumors 0 1 8666391 (1)

    Genetic Association Database (GAD): EPHB1
    Human Genome Epidemiology (HuGE) Navigator: EPHB1 (8 documents)

    Export disorders for EPHB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EPHB1 gene, integrated from 10 sources (see all 76):
    (articles sorted by number of sources associating them with EPHB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein- tyrosine kinase gene preferentially expressed in brain. (PubMed id 8666391)1, 2, 3, 9 Tang X.X.... Ikegaki N. (Genomics 1995)
    2. Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway. (PubMed id 18034775)1, 2, 9 Fasen K.... Huynh-Do U. (Traffic 2008)
    3. EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. (PubMed id 12925710)1, 2, 9 Vindis C.... Huynh-Do U. (J. Cell Biol. 2003)
    4. The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1. (PubMed id 11713248)1, 2, 9 Freywald A.... Roifman C.M. (J. Biol. Chem. 2002)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression. (PubMed id 19736353)1, 4 Ising M....MA1ller-Myhsok B. (Arch. Gen. Psychiatry 2009)
    7. Replication of a genome-wide case-control study of esophageal squamous cell carcinoma. (PubMed id 18649358)1, 4 Ng D....Taylor P.R. (Int. J. Cancer 2008)
    8. Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease. (PubMed id 18628988)1, 4 Li Y....Hadjigeorgiou G. (PLoS ONE 2008)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2047 HGNC: 3392 AceView: EPHB1 Ensembl:ENSG00000154928 euGenes: HUgn2047
    ECgene: EPHB1 Kegg: 2047 H-InvDB: EPHB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for EPHB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EPHB1 gene:
    Search GeneIP for patents involving EPHB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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