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EPHA8 Gene

protein-coding   GIFtS: 66
GCID: GC01P022890

EPH Receptor A8

(Previous name: EphA8)
(Previous symbol: EEK)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
EPH Receptor A81 2     EPH- And ELK-Related Tyrosine Kinase2
EEK1 2 3 5     Ephrin Type-A Receptor 82
HEK32 3 5     Hydroxyaryl-Protein Kinase2
Tyrosine-Protein Kinase Receptor EEK2 3     Protein-Tyrosine Kinase2
EK32 3     Tyrosylprotein Kinase2
EPH- And ELK-Related Kinase2 3     KIAA14593
EPH-Like Kinase 32 3     hEK33
EC 2.7.10.13 8     EC 2.7.108
EphA81     

External Ids:    HGNC: 33911   Entrez Gene: 20462   Ensembl: ENSG000000708867   OMIM: 1769455   UniProtKB: P293223   

Export aliases for EPHA8 gene to outside databases

Previous GC identifers: GC01P022459 GC01P021925 GC01P022035 GC01P022359 GC01P022635 GC01P022762 GC01P021133


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EPHA8 Gene:
This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and
EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system.
Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a
Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the
similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B
ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in
short-range contact-mediated axonal guidance during development of the mammalian nervous system. (provided by
RefSeq, Jul 2008)

GeneCards Summary for EPHA8 Gene:
EPHA8 (EPH receptor A8) is a protein-coding gene. Diseases associated with EPHA8 include adenocarcinoma, and pancreatitis. GO annotations related to this gene include GPI-linked ephrin receptor activity. An important paralog of this gene is EPHB1.

UniProtKB/Swiss-Prot: EPHA8_HUMAN, P29322
Function: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on
adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able
to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration
on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role
in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion
upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity)

Gene Wiki entry for EPHA8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the EPHA8 gene promoter:
         C/EBPbeta   NRSF form 1   Pax-2   Pax-2a   Nkx5-1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEPHA8 promoter sequence
   Search Chromatin IP Primers for EPHA8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EPHA8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.12   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.12

EPHA8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHA8 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P022890:  view genomic region     (about GC identifiers)

Start:
22,890,004 bp from pter      End:
22,930,087 bp from pter
Size:
40,084 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: EPHA8_HUMAN, P29322 (See protein sequence)
Recommended Name: Ephrin type-A receptor 8 precursor  
Size: 1005 amino acids; 111003 Da
Subunit: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a
receptor dimer. Oligomerization is probably required to induce biological responses. May also form heterodimers
with other ephrin receptors (By similarity). Interacts with FYN; possible downstream effector of EPHA8 in
regulation of cell adhesion. Interacts with PIK3CG; regulates integrin-mediated cell adhesion to substrate.
Interacts with TIAM1; regulates clathrin-mediated endocytosis of EPHA8. Interacts with ANKS1A and ANKS1B; EPHA8
kinase activity-independent but stimulated by EPHA8 ubiquitination
Sequence caution: Sequence=CAA41980.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
3 PDB 3D structures from and Proteopedia for EPHA8:
1UCV (3D)        1X5L (3D)        3KUL (3D)    
Secondary accessions: Q6IN80 Q8IUX6 Q9NUA9 Q9P269
Alternative splicing: 2 isoforms:  P29322-1   P29322-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EPHA8: NX_P29322

Explore proteomics data for EPHA8 at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation is stimulated upon binding of its ligands including EFNA2, EFNA3 and EFNA5.
    Autophosphorylation on Tyr-616 is critical for association with FYN. Autophosphorylation on Tyr-839 modulates
    tyrosine kinase activity (By similarity)1
  • Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal
    degradation. ANKS1A prevents ubiquitination and degradation (By similarity)1
  • Glycosylation2 at Asn340, Asn407, Asn432
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for EPHA8 (P29322) (see all 24)
     NGVSDLS  DTIAADE  RDLAARN  TYQVCNV 


    See EPHA8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001006944.1  NP_065387.1  

    ENSEMBL proteins: 
     ENSP00000363775   ENSP00000166244   ENSP00000440274  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    EPH: EPH receptors
    SAMD: Sterile alpha motif (SAM) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: EPH receptor A8
    Ephrin receptor family
    Ephrin receptor family

    Selected InterPro protein domains (see all 17):
     IPR017441 Protein_kinase_ATP_BS
     IPR003961 Fibronectin_type3
     IPR021129 SAM_type1
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P29322

    ProtoNet protein and cluster: P29322

    5 Blocks protein domains:
    IPB001090 Ephrin receptor
    IPB001426 Receptor tyrosine kinase
    IPB001660 Sterile alpha motif SAM
    IPB003962 Fibronectin type III repeat signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EPHA8_HUMAN, P29322
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    EPHA8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EPHA8_HUMAN, P29322
    Function: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on
    adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
    pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
    the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able
    to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration
    on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role
    in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion
    upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity)
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for EPHA8:
    EPH-related tyrosine kinase receptor,binding ephrin A2,A3,A5,expressed in projecting neurons and their target
    fields,involved in short-range contact-mediated axonal guidance

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0005003ephrin receptor activity ----
    GO:0005004GPI-linked ephrin receptor activity ISS--
    GO:0005515protein binding ----
         
    EPHA8 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for EPHA8:
     Decreased focal adhesion (FA)   Decreased substrate adherent c 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Epha8):
     cellular  nervous system 

    EPHA8 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EPHA8
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EPHA8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EPHA8

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate EPHA8 (see all 46):
    hsa-miR-25 hsa-miR-374a hsa-miR-218 hsa-miR-507 hsa-miR-654-5p hsa-miR-3148 hsa-miR-92b hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidEPHA8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for EPHA8
    Predesigned siRNA for gene silencing in human, mouse, rat EPHA8

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): EPHA8 (NM_020526)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EPHA8_HUMAN, P29322: Cell membrane (By similarity); Single-pass type I membrane protein (By similarity). Cell
    projection (By similarity). Early endosome membrane (By similarity). Note=Undergoes clathrin-mediated endocytosis
    upon EFNA5-binding and is targeted to early endosomes (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endosome2
    cytosol1
    extracellular1
    lysosome1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane ISS--
    GO:0031901early endosome membrane IEA--
    GO:0043005neuron projection ISS--

    EPHA8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EPHA8 About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.41
    Actin Nucleation by ARP-WASP Complex0.66
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EPHA8 (see all 32)
        Paxillin Interactions
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    JNK Pathway
    P2Y Receptor Signaling

    3 GeneGo (Thomson Reuters) Pathways for EPHA8
        Neurophysiological process Receptor-mediated axon growth repulsion
    G-protein signaling RhoA regulation pathway
    Cell adhesion Ephrins signaling

    2 BioSystems Pathways for EPHA8
        EPHA forward signaling
    EphrinA-EPHA pathway


    1 Kegg Pathway  (Kegg details for EPHA8):
        Axon guidance


    EPHA8 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EPHA8
    Interactions:

        GeneGlobe Interaction Network for EPHA8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for EPHA8 (P293222, 3 ENSP000001662444) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF746Q6NUN92, 3, ENSP000003451404MINT-8254974 I2D: score=2 STRING: ENSP00000345140
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    ANKS1AQ926253, ENSP000003535184I2D: score=1 STRING: ENSP00000353518
    EFNA1P208273, ENSP000003573924I2D: score=1 STRING: ENSP00000357392
    EFNA5P528033, ENSP000003287774I2D: score=1 STRING: ENSP00000328777
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0006929substrate-dependent cell migration ISS--
    GO:0007155cell adhesion IEA--
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway ----
    GO:0007411axon guidance ISS--

    EPHA8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EPHA8

    2 HMDB Compounds for EPHA8    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 Novoseek inferred chemical compound relationship for EPHA8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 21.6 4 10498895 (2), 12681484 (1)



    EPHA8 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for EPHA8 gene (2 alternative transcripts): 
    NM_001006943.1  NM_020526.3  

    Unigene Cluster for EPHA8:

    EPH receptor A8
    Hs.283613  [show with all ESTs]
    Unigene Representative Sequence: NM_020526
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374644(uc001bfw.3) ENST00000166244(uc001bfx.1) ENST00000538803

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    hsa-miR-25 hsa-miR-374a hsa-miR-218 hsa-miR-507 hsa-miR-654-5p hsa-miR-3148 hsa-miR-92b hsa-miR-4324
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      QuantiFast Probe-based Assays in human, mouse, rat EPHA8

    Additional mRNA sequence: 

    AB040892.1 BC038796.1 BC072417.1 

    2 DOTS entries:

    DT.97836676  DT.75139119 

    22 AceView cDNA sequences:

    BM725229 NM_020526 CR614037 AI813918 BC072417 BM678240 BX107079 CK904440 
    AL528782 BM023175 AI967980 BM926981 BM023457 BC038796 AB040892 AL528781 
    BX345521 AI268742 BX345522 BM711849 BU184251 BE222104 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EPHA8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    EPHA8 Expression
    About this image


    EPHA8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Thalamus
             Septum   
     
     Epiblast (Early Embryonic Tissues)
             Epiblast-like cells
    EPHA8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EPHA8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.283613
        Custom PCR Arrays for EPHA8
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for EPHA8 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Epha81 , 5 Eph receptor A81, 5 87.78(n)1
    94.82(a)1
      4 (69.05 cM)5
    138421  NM_007939.21  NP_031965.21 
     1369294195 
    chicken
    (Gallus gallus)
    Aves EPHA81 EPH receptor A8 78.03(n)
    81.87(a)
      428198  XM_003642540.2  XP_003642588.2 
    lizard
    (Anolis carolinensis)
    Reptilia EPHA86
    EPH receptor A8
    79(a)
    1 ↔ 1
    GL344067.1(41810-75953)
    zebrafish
    (Danio rerio)
    Actinopterygii epha86
    eph receptor A8
    67(a)
    1 ↔ 1
    11(39958895-40108036) ENSDARG00000023609


    ENSEMBL Gene Tree for EPHA8 (if available)
    TreeFam Gene Tree for EPHA8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EPHA8 gene
    EPHB12  EPHA22  EPHB32  EPHA42  EPHA52  EPHB62  EPHA62  EPHA12  
    EPHB22  EPHA32  EPHA72  EPHA102  EPHB42  
    14 SIMAP similar genes for EPHA8 using alignment to 1 protein entry:     EPHA8_HUMAN:
    EPHA3    EPHA6    EPHA4    EPHA7    EPHB2 variant protein    EPHB2
    EPHB1    EPHA5    EPHB3    EPHA2    EPHA10    EPHB4
    EPHB6    EPHA1

    EPHA8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EPHA8 (see all 1363)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0421574
    A lung adenocarcinoma sample4--see VAR_0421572 R L mis40--------
    VAR_0421564
    A gastric adenocarcinoma sample4--see VAR_0421562 R C mis40--------
    VAR_0421554
    A breast infiltrating ductal carcinoma sample4--see VAR_0421552 N K mis40--------
    VAR_0421584
    A metastatic melanoma sample4--see VAR_0421582 P L mis40--------
    rs2097391,2
    C,F--21133257(+) CGGCGG/ATGGCC 2 /T /A mis12Minor allele frequency- A:0.00NA 4
    rs2097381,2
    C,F--21133285(+) GGTGCG/AGGCTC 1 -- int12Minor allele frequency- A:0.18WA NA 122
    rs3686678731,2
    C--21133301(+) CCCCC-/CCCCCC 1 -- int10--------
    rs1441028311,2
    --22888038(+) ATTACA/CGGCAT 2 -- us2k10--------
    rs1163362561,2
    C,F--22888182(+) GCTACG/AGCCAC 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1156782441,2
    C,F--22888205(+) TCTGCC/TTACAC 2 -- us2k11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for EPHA8 (22890004 - 22930087 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for EPHA8 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv28e199CNV Deletion23128226
    esv3577CNV Deletion18987735
    esv2745175CNV Deletion23290073
    esv4502CNV Deletion18987735
    esv2745219CNV Deletion23290073
    esv2745164CNV Deletion23290073
    esv2745186CNV Deletion23290073
    esv2677455CNV Deletion23128226
    esv2745208CNV Deletion23290073
    esv2745197CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing EPHA8
    DNA2.0 Custom Variant and Variant Library Synthesis for EPHA8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176945    OMIM disorders: --

    5 diseases for EPHA8:    
    About MalaCards
    adenocarcinoma    pancreatitis    neuronitis    cerebritis
    breast cancer


    EPHA8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): EPHA8
    Human Genome Epidemiology (HuGE) Navigator: EPHA8 (2 documents)

    Export disorders for EPHA8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EPHA8 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with EPHA8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. eek and erk, new members of the eph subclass of receptor protein- tyrosine kinases. (PubMed id 1648701)1, 2, 3, 9 Chan J. and Watt V.M. (Oncogene 1991)
    2. Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity. (PubMed id 10498895)1, 2, 9 Choi S. and Park S. (Oncogene 1999)
    3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity- independent manner. (PubMed id 11416136)1, 2 Gu C. and Park S. (Mol. Cell. Biol. 2001)
    6. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    7. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PubMed id 9267020)1, 2 (Cell 1997)
    8. Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function. (PubMed id 17875921)2, 9 Shin J.... Park S. (Mol. Cell. Biol. 2007)
    9. The p110 gamma PI-3 kinase is required for EphA8-stimulated cell migration. (PubMed id 12681484)1, 9 Gu C. and Park S. (FEBS Lett. 2003)
    10. RINL, guanine nucleotide exchange factor Rab5-subfamily, is involved in the EphA8-degradation pathway with odin. (PubMed id 22291991)1 Kajiho H....Katada T. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2046 HGNC: 3391 AceView: EPHA8 Ensembl:ENSG00000070886 euGenes: HUgn2046
    ECgene: EPHA8 Kegg: 2046 H-InvDB: EPHA8

    (According to HUGE)
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    HUGE: KIAA1459

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EPHA8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EPHA8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for EPHA8 gene:
    Search GeneIP for patents involving EPHA8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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