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Aliases for EPHA8 Gene

Aliases for EPHA8 Gene

  • EPH Receptor A8 2 3
  • HEK3 3 4 6
  • EEK 3 4 6
  • Tyrosine-Protein Kinase Receptor EEK 3 4
  • EPH- And ELK-Related Kinase 3 4
  • EPH-Like Kinase 3 3 4
  • EC 2.7.10.1 4 64
  • EK3 3 4
  • EPH- And ELK-Related Tyrosine Kinase 3
  • Hydroxyaryl-Protein Kinase 3
  • Ephrin Type-A Receptor 8 3
  • Protein-Tyrosine Kinase 3
  • Tyrosylprotein Kinase 3
  • EC 2.7.10 64
  • KIAA1459 4
  • EphA8 2

External Ids for EPHA8 Gene

Previous Symbols for EPHA8 Gene

  • EEK

Summaries for EPHA8 Gene

Entrez Gene Summary for EPHA8 Gene

  • This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for EPHA8 Gene

EPHA8 (EPH Receptor A8) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Akt Signaling. GO annotations related to this gene include GPI-linked ephrin receptor activity. An important paralog of this gene is EPHB3.

UniProtKB/Swiss-Prot for EPHA8 Gene

  • Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity).

Gene Wiki entry for EPHA8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHA8 Gene

Genomics for EPHA8 Gene

Genomic Location for EPHA8 Gene

Start:
22,563,511 bp from pter
End:
22,603,594 bp from pter
Size:
40,084 bases
Orientation:
Plus strand

Genomic View for EPHA8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EPHA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPHA8 Gene

Regulatory Elements for EPHA8 Gene

Proteins for EPHA8 Gene

  • Protein details for EPHA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29322-EPHA8_HUMAN
    Recommended name:
    Ephrin type-A receptor 8
    Protein Accession:
    P29322
    Secondary Accessions:
    • Q6IN80
    • Q8IUX6
    • Q9NUA9
    • Q9P269

    Protein attributes for EPHA8 Gene

    Size:
    1005 amino acids
    Molecular mass:
    111003 Da
    Quaternary structure:
    • Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. May also form heterodimers with other ephrin receptors (By similarity). Interacts with FYN; possible downstream effector of EPHA8 in regulation of cell adhesion. Interacts with PIK3CG; regulates integrin-mediated cell adhesion to substrate. Interacts with TIAM1; regulates clathrin-mediated endocytosis of EPHA8. Interacts with ANKS1A and ANKS1B; EPHA8 kinase activity-independent but stimulated by EPHA8 ubiquitination.
    SequenceCaution:
    • Sequence=CAA41980.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EPHA8 Gene

    Alternative splice isoforms for EPHA8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPHA8 Gene

Proteomics data for EPHA8 Gene at MOPED

Post-translational modifications for EPHA8 Gene

  • Phosphorylated. Phosphorylation is stimulated upon binding of its ligands including EFNA2, EFNA3 and EFNA5. Autophosphorylation on Tyr-616 is critical for association with FYN. Autophosphorylation on Tyr-839 modulates tyrosine kinase activity (By similarity).
  • Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation. ANKS1A prevents ubiquitination and degradation (By similarity).
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn340, Asn407, and Asn432

Other Protein References for EPHA8 Gene

Domains for EPHA8 Gene

Gene Families for EPHA8 Gene

HGNC:
  • SAMD :Sterile alpha motif (SAM) domain containing
  • FN3 :Fibronectin type III domain containing
  • EPH :EPH receptors
IUPHAR :

UniProtKB/Swiss-Prot:

EPHA8_HUMAN
Domain:
  • Contains 1 Eph LBD (Eph ligand-binding) domain.:
    • P29322
  • Contains 2 fibronectin type-III domains.:
    • P29322
  • Contains 1 protein kinase domain.:
    • P29322
  • Contains 1 SAM (sterile alpha motif) domain.:
    • P29322
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.:
    • P29322
genes like me logo Genes that share domains with EPHA8: view

Function for EPHA8 Gene

Molecular function for EPHA8 Gene

GENATLAS Biochemistry: EPH-related tyrosine kinase receptor,binding ephrin A2,A3,A5,expressed in projecting neurons and their target fields,involved in short-range contact-mediated axonal guidance
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity).

Enzyme Numbers (IUBMB) for EPHA8 Gene

Gene Ontology (GO) - Molecular Function for EPHA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity --
GO:0005003 ephrin receptor activity --
GO:0005004 GPI-linked ephrin receptor activity ISS --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with EPHA8: view

Phenotypes for EPHA8 Gene

genes like me logo Genes that share phenotypes with EPHA8: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for EPHA8 Gene

Localization for EPHA8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHA8 Gene

Cell membrane; Single-pass type I membrane protein. Cell projection. Early endosome membrane. Note=Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPHA8 Gene COMPARTMENTS Subcellular localization image for EPHA8 gene
Compartment Confidence
plasma membrane 4
endosome 2
cytosol 1
extracellular 1
lysosome 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for EPHA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS --
GO:0031901 early endosome membrane IEA --
GO:0043005 neuron projection ISS --
genes like me logo Genes that share ontologies with EPHA8: view

Pathways for EPHA8 Gene

genes like me logo Genes that share pathways with EPHA8: view

Pathways by source for EPHA8 Gene

Gene Ontology (GO) - Biological Process for EPHA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0006929 substrate-dependent cell migration ISS --
GO:0007155 cell adhesion IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway --
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with EPHA8: view

Compounds for EPHA8 Gene

(2) HMDB Compounds for EPHA8 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(1) Novoseek inferred chemical compound relationships for EPHA8 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 21.6 3
genes like me logo Genes that share compounds with EPHA8: view

Transcripts for EPHA8 Gene

Unigene Clusters for EPHA8 Gene

EPH receptor A8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EPHA8 Gene

No ASD Table

Relevant External Links for EPHA8 Gene

GeneLoc Exon Structure for
EPHA8
ECgene alternative splicing isoforms for
EPHA8

Expression for EPHA8 Gene

mRNA expression in normal human tissues for EPHA8 Gene

mRNA differential expression in normal tissues according to GTEx for EPHA8 Gene

This gene is overexpressed in Spleen (9.5) and Testis (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for EPHA8 Gene

SOURCE GeneReport for Unigene cluster for EPHA8 Gene Hs.283613

genes like me logo Genes that share expressions with EPHA8: view

Orthologs for EPHA8 Gene

This gene was present in the common ancestor of animals.

Orthologs for EPHA8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EPHA8 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EPHA8 36
  • 91.92 (n)
  • 97.43 (a)
EPHA8 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EPHA8 36
  • 92.6 (n)
  • 97.21 (a)
EPHA8 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Epha8 36
  • 87.78 (n)
  • 94.82 (a)
Epha8 16
Epha8 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EPHA8 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Epha8 36
  • 87.28 (n)
  • 94.67 (a)
chicken
(Gallus gallus)
Aves EPHA8 36
  • 78.03 (n)
  • 81.87 (a)
EPHA8 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EPHA8 37
  • 79 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii epha8 37
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Eph 38
  • 39 (a)
hop 38
  • 37 (a)
Species with no ortholog for EPHA8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EPHA8 Gene

ENSEMBL:
Gene Tree for EPHA8 (if available)
TreeFam:
Gene Tree for EPHA8 (if available)

Paralogs for EPHA8 Gene

Paralogs for EPHA8 Gene

Selected SIMAP similar genes for EPHA8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EPHA8: view

Variants for EPHA8 Gene

Sequence variations from dbSNP and Humsavar for EPHA8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs209689 -- 22,596,536(-) TGGGG(C/T)GTGGA intron-variant
rs209690 -- 22,596,307(+) TCCAG(A/G)GTGTC intron-variant
rs209691 -- 22,596,067(+) TAGGG(A/G)TGGCC intron-variant
rs209692 -- 22,596,053(+) GTCAG(A/G)TCCCG intron-variant
rs209693 -- 22,595,533(+) GTTAG(G/T)CTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EPHA8 Gene

Variant ID Type Subtype PubMed ID
nsv509024 CNV Insertion 20534489
nsv871044 CNV Loss 21882294
nsv870779 CNV Loss 21882294
esv26050 CNV Gain 19812545
esv259650 OTHER Complex 20981092
esv259678 OTHER Complex 20981092
esv994542 CNV Insertion 20482838
esv3577 CNV Deletion 18987735
dgv28e199 CNV Deletion 23128226
nsv820259 CNV Insertion 19587683
esv1707275 CNV Insertion 17803354
nsv160591 CNV Loss 16902084
esv2677455 CNV Deletion 23128226
esv2745164 CNV Deletion 23290073
esv4502 CNV Deletion 18987735
esv2745175 CNV Deletion 23290073
esv2745186 CNV Deletion 23290073
esv2745197 CNV Deletion 23290073
esv2745208 CNV Deletion 23290073
esv2745219 CNV Deletion 23290073
esv34161 CNV Loss 18971310

Relevant External Links for EPHA8 Gene

HapMap Linkage Disequilibrium report
EPHA8

Disorders for EPHA8 Gene

Relevant External Links for EPHA8

Genetic Association Database (GAD)
EPHA8
Human Genome Epidemiology (HuGE) Navigator
EPHA8
genes like me logo Genes that share disorders with EPHA8: view

No data available for UniProtKB/Swiss-Prot for EPHA8 Gene

Publications for EPHA8 Gene

  1. eek and erk, new members of the eph subclass of receptor protein- tyrosine kinases. (PMID: 1648701) Chan J. … Watt V.M. (Oncogene 1991) 2 3 4 23
  2. Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity. (PMID: 10498895) Choi S. … Park S. (Oncogene 1999) 3 4 23
  3. The p110 gamma PI-3 kinase is required for EphA8-stimulated cell migration. (PMID: 12681484) Gu C. … Park S. (FEBS Lett. 2003) 3 23
  4. Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function. (PMID: 17875921) Shin J. … Park S. (Mol. Cell. Biol. 2007) 4 23
  5. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4

Products for EPHA8 Gene

  • Addgene plasmids for EPHA8

Sources for EPHA8 Gene

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