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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EPHA8 Gene

protein-coding   GIFtS: 65
GCID: GC01P022890

EPH receptor A8

(Previous name: EphA8 )
(Previous symbol: EEK)
 Explore 5 diseases affiliated with
EPHA8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for EPHA8    

Aliases
for EPHA8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
EPH Receptor A81 2     Hek31
EEK1 2 3 5     EPH- And ELK-Related Tyrosine Kinase2
HEK32 3 5     Ephrin Type-A Receptor 82
Tyrosine-Protein Kinase Receptor EEK2 3     Hydroxyaryl-Protein Kinase2
EK32 3     Protein-Tyrosine Kinase2
EPH- And ELK-Related Kinase2 3     Tyrosylprotein Kinase2
EPH-Like Kinase 32 3     KIAA14593
EC 2.7.10.13 8     HEK32 3 5
EphA81     EC 2.7.108

External Ids:    HGNC: 33911   Entrez Gene: 20462   Ensembl: ENSG000000708867   OMIM: 1769455   UniProtKB: P293223   

Export aliases for EPHA8 gene to outside databases

Previous GC identifers: GC01P022459 GC01P021925 GC01P022035 GC01P022359 GC01P022635 GC01P022762 GC01P021133


Summaries
for EPHA8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for EPHA8:
This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related
receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the
EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2
fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their
extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by
this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal
guidance during development of the mammalian nervous system. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: EPHA8_HUMAN, P29322
Function: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent
cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream
of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is
referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through
phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but
also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream
effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP
kinases in the stimulation of neurite outgrowth (By similarity)

Gene Wiki entry for EPHA8


Genomic Views
for EPHA8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EPHA8 gene promoter:
         C/EBPbeta   NRSF form 1   Pax-2   Pax-2a   Nkx5-1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EPHA8 promoter sequence
   Search SABiosciences Chromatin IP Primers for EPHA8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPHA8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.12   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.12

EPHA8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHA8 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P022890:  view genomic region     (about GC identifiers)

Start:
 22,890,004 bp from pter      End:
 22,930,087 bp from pter
Size:
 40,084 bases      Orientation:
 plus strand

Proteins
for EPHA8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: EPHA8_HUMAN, P29322 (See protein sequence)
Recommended Name: Ephrin type-A receptor 8 precursor  
Size: 1005 amino acids; 111003 Da
Subunit: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor
dimer. Oligomerization is probably required to induce biological responses. May also form heterodimers with other
ephrin receptors (By similarity). Interacts with FYN; possible downstream effector of EPHA8 in regulation of cell
adhesion. Interacts with PIK3CG; regulates integrin-mediated cell adhesion to substrate. Interacts with TIAM1;
regulates clathrin-mediated endocytosis of EPHA8. Interacts with ANKS1A and ANKS1B; EPHA8 kinase activity-independent
but stimulated by EPHA8 ubiquitination
Subcellular location: Cell membrane (By similarity); Single-pass type I membrane protein (By similarity). Cell
projection (By similarity). Early endosome membrane (By similarity). Note=Undergoes clathrin-mediated endocytosis upon
EFNA5-binding and is targeted to early endosomes (By similarity)
Sequence caution: Sequence=CAA41980.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
3 PDB 3D structures from and Proteopedia for EPHA8:
1UCV (3D)        1X5L (3D)        3KUL (3D)    
Secondary accessions: Q6IN80 Q8IUX6 Q9NUA9 Q9P269
Alternative splicing: 2 isoforms:  P29322-1   P29322-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for EPHA8: NX_P29322

Post-translational modifications:

  • Phosphorylated. Phosphorylation is stimulated upon binding of its ligands including EFNA2, EFNA3 and EFNA5.
    • Autophosphorylation on Tyr-616 is critical for association with FYN. Autophosphorylation on Tyr-839 modulates tyrosine
    kinase activity (By similarity)1
  • Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation.
    • ANKS1A prevents ubiquitination and degradation (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P29322

    • 4/24 DME Specific Peptides for EPHA8 (P29322) (see all 24)
     NGVSDLS  DTIAADE  RDLAARN  TYQVCNV 

    EPHA8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001006944.1  NP_065387.1  

    ENSEMBL proteins: 
     ENSP00000166244   ENSP00000363775   ENSP00000440274  

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    Uscn Proteins for EPHA8

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane ISS--
    GO:0031901early endosome membrane IEA--
    GO:0043005neuron projection ISS--


    EPHA8 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for EPHA8

    Protein Domains /
    Families
    for EPHA8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    EPHA8 for domains           About GeneDecksing

    5/16 InterPro domains/families (see all 16):
     IPR017441 Protein_kinase_ATP_BS
     IPR003961 Fibronectin_type3
     IPR021129 SAM_type1
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P29322

    ProtoNet protein and cluster: P29322

    5 Blocks protein families:
    IPB001090 Ephrin receptor
    IPB001426 Receptor tyrosine kinase
    IPB001660 Sterile alpha motif SAM
    IPB003962 Fibronectin type III repeat signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EPHA8_HUMAN, P29322
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Function
    for EPHA8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: EPHA8_HUMAN, P29322
    Function: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent
    cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream
    of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is
    referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through
    phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but
    also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream
    effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP
    kinases in the stimulation of neurite outgrowth (By similarity)
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for EPHA8:
    EPH-related tyrosine kinase receptor,binding ephrin A2,A3,A5,expressed in projecting neurons and their target
    fields,involved in short-range contact-mediated axonal guidance

    Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

    miRNA
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    hsa-miR-25 hsa-miR-374a hsa-miR-218 hsa-miR-507 hsa-miR-654-5p hsa-miR-3148 hsa-miR-92b hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmid: EPHA8 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPHA8

    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005004GPI-linked ephrin receptor activity ISS--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--


    EPHA8 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for EPHA8:
     Decreased focal adhesion (FA)   Decreased substrate adherent c 

    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Epha8):
     cellular  nervous system 

    EPHA8 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for EPHA8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    		P2Y Receptor Signaling0.38
    2Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    3Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		14-3-3 Induced Intracellular Signaling0.59
    		GSK3 Signaling0.61
    		eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    		Actin Nucleation by ARP-WASP Complex1.00
    		CDC42 Pathway0.34
    		Actin Nucleation and Branching0.66
    5G-protein signaling_RhoA regulation pathway
    		G-protein signaling_RhoA regulation pathway1.00
    		EphrinA-EphR Signaling0.26
    		G-protein signaling RhoA regulation pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for EPHA8
        Neurophysiological process Receptor-mediated axon growth repulsion
    Cell adhesion Ephrins signaling
    G-protein signaling RhoA regulation pathway

    5/32 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EPHA8 (see all 32)
        Paxillin Interactions
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    JNK Pathway
    P2Y Receptor Signaling

    3 GeneGo (Thomson Reuters) Pathways for EPHA8
        Neurophysiological process Receptor-mediated axon growth repulsion
    G-protein signaling RhoA regulation pathway
    Cell adhesion Ephrins signaling

    2 BioSystems Pathways for EPHA8 
        EPHA forward signaling
    EphrinA-EPHA pathway


    1         Kegg Pathway  (Kegg details for EPHA8):
        Axon guidance


    EPHA8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EPHA8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/14 Interacting proteins for EPHA8 (P293222, 3 ENSP000001662444) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF746Q6NUN92, 3, ENSP000003451404MINT-8254974 I2D: score=2 STRING: ENSP00000345140
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    ANKS1AQ926253, ENSP000003535184I2D: score=1 STRING: ENSP00000353518
    EFNA1P208273, ENSP000003573924I2D: score=1 STRING: ENSP00000357392
    EFNA5P528033, ENSP000003287774I2D: score=1 STRING: ENSP00000328777
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006929substrate-dependent cell migration ISS--
    GO:0007155cell adhesion IEA--
    GO:0007411axon guidance ISS--
    GO:0016322neuron remodeling ISS--
    GO:0030155regulation of cell adhesion ISS--


    EPHA8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for EPHA8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EPHA8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for EPHA8

    2 HMDB Compounds for EPHA8    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    1 Novoseek chemical compound relationship for EPHA8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 21.6 4 10498895 (2), 12681484 (1)

    Search CenterWatch for drugs/clinical trials and news about EPHA8 

    Transcripts
    for EPHA8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for EPHA8 gene (2 alternative transcripts): 
    NM_001006943.1  NM_020526.3  

    Unigene Cluster for EPHA8:

    EPH receptor A8
    Hs.283613  [show with all ESTs]
    Unigene Representative Sequence: NM_020526
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000166244(uc001bfx.1) ENST00000374644(uc001bfw.3) ENST00000538803


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    hsa-miR-25 hsa-miR-374a hsa-miR-218 hsa-miR-507 hsa-miR-654-5p hsa-miR-3148 hsa-miR-92b hsa-miR-4324
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    Primer
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    Additional cDNA sequence: 

    AB040892.1 BC038796.1 BC072417.1 

    2 DOTS entries:

    DT.97836676  DT.75139119 

    22 AceView cDNA sequences:

    CR614037 NM_020526 AI813918 BC072417 BM678240 BM725229 BM023175 BM926981 
    AI967980 BX107079 AL528782 AB040892 CK904440 BM023457 BC038796 AL528781 
    BX345521 AI268742 BX345522 BU184251 BM711849 BE222104 

    GeneLoc Exon Structure


    Expression
    for EPHA8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EPHA8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    EPHA8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainThalamusBrain
    Neural TubeDiencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Epiblast-like cells (Reconstitution of mo...)

    See EPHA8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EPHA8

    SOURCE GeneReport for Unigene cluster: Hs.283613
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    In Situ
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    Orthologs
    for EPHA8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for EPHA8 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC4281981 ephrin type-A receptor 8-like 77.87(n)
    81.28(a)    		   428198  XM_003642540.1  XP_003642588.1 
    lizard
    (Anolis carolinensis)    		 Reptilia EPHA86
    		 --
    		 79(a)
    		 1 ↔ 1
    		 GL344067.1(43745-75953)
    zebrafish
    (Danio rerio)    		 Actinopterygii epha86
    CABZ01084877.16
    (see all 3)    		 --
    		 67(a)
    34(a)
    (see all 3)    		 1 ↔ 1
    possible ortholog
    (see all 3)    		 11(39958895-40108036)
    Zv9_NA779(312-23840)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Eph3 protein amino acid phosphorylation
    transmembrane more    		 39(a)
    (best of 2)    		   102C2   --
    worm
    (Caenorhabditis elegans)    		 Secernentea vab-16
    kin-246
    (see all 6)    		 protein KINase family member (kin-24)
    (see all 6)    		 27(a)
    17(a)
    (see all 6)    		 possible ortholog
    possible ortholog
    (see all 6)    		 II(4571997-4591357)
    IV(9839089-9841052)


    ENSEMBL Gene Tree for EPHA8 (if available)
    TreeFam Gene Tree for EPHA8 (if available) 

    Paralogs
    for EPHA8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EPHA8 gene
    EPHB12  EPHA22  EPHB32  EPHA42  EPHA52  EPHB62  EPHA62  EPHB22  
    EPHA12  EPHA32  EPHA72  EPHB42  EPHA102  
    14 SIMAP similar genes for EPHA8 using alignment to 1 protein entry:     EPHA8_HUMAN:
    EPHA3    EPHA6    EPHA4    EPHA7    EPHB2 variant protein    EPHB2
    EPHB1    EPHA5    EPHB3    EPHA2    EPHA10    EPHB4
    EPHB6    EPHA1

    EPHA8 for paralogs           About GeneDecksing



    Genomic Variants
    for EPHA8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1074 NCBI SNPs in EPHA8 are shown (see all 1074)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1441028311,2
    		--22888038(+) ATTACA/CGGCAT 2 -- us2k10--------
    rs1163362561,2
    		F,--22888182(+) GCTACG/AGCCAC 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1156782441,2
    		F,--22888205(+) TCTGCC/TTACAC 2 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1506898411,2
    		--22888241(+) TAGCTG/TCCAAC 2 -- us2k10--------
    rs1150968001,2
    		C,--22888262(+) AAGACG/ATAACA 2 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1896545681,2
    		--22888366(+) TCCTAC/GCAGGC 2 -- us2k10--------
    rs726513331,2
    		C,F,--22888397(+) TCTCAT/GGTAGG 2 -- us2k11Minor allele frequency- G:0.08NA 120
    rs1812460821,2
    		--22888430(+) TCTAGC/TCCAAT 2 -- us2k10--------
    rs1498192261,2
    		--22888449(+) TACTCA/GCCTGC 2 -- us2k10--------
    rs1851893371,2
    		--22888517(+) ACAGGA/GGTCTC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for EPHA8 (22890004 - 22930087 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for EPHA8
         7 CNVs: 84128 74411 5476 59627 47887 23355 68219
         3 Indels: 41425 68218 41739

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    Disorders / Diseases
    for EPHA8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    EPHA8 for disorders           About GeneDecksing

    OMIM gene information: 176945    OMIM disorders: --

    5 diseases for EPHA8:    About MalaCards
    duodenum cancer    neuronitis    breast cancer    adenocarcinoma
    pancreatitis

    Human Genome Epidemiology (HuGE) Navigator: EPHA8 (2 documents)

    Export disorders for EPHA8 gene to outside databases

    Publications
    for EPHA8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EPHA8 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with EPHA8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. eek and erk, new members of the eph subclass of receptor protein- tyrosine kinases. (PubMed id 1648701)1, 2, 3, 9 Chan J. and Watt V.M. (1991)
    2. Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity. (PubMed id 10498895)1, 2, 9 Choi S. and Park S. (1999)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner. (PubMed id 11416136)1, 2 Gu C. and Park S. (2001)
    5. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    6. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PubMed id 9267020)1, 2 (1997)
    7. Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function. (PubMed id 17875921)2, 9 Shin J.... Park S. (2007)
    8. The p110 gamma PI-3 kinase is required for EphA8-stimulated cell migration. (PubMed id 12681484)1, 9 Gu C. and Park S. (2003)
    9. RINL, guanine nucleotide exchange factor Rab5-subfamil y, is involved in the EphA8-degradation pathway with odin. (PubMed id 22291991)1 Kajiho H....Katada T. (2012)
    10. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)

    External Searches for EPHA8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing EPHA8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2046 HGNC: 3391 AceView: EPHA8 Ensembl:ENSG00000070886 euGenes: HUgn2046
    ECgene: EPHA8 Kegg: 2046 H-InvDB: EPHA8

    Other Databases showing EPHA8 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1459

    Specialized Databases showing EPHA8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EPHA8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EPHA8 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for EPHA8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for EPHA8 gene:
    Search GeneIP for patents involving EPHA8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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