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Aliases for EPHA7 Gene

Aliases for EPHA7 Gene

  • EPH Receptor A7 2 3 5
  • EPH Homology Kinase 3 3 4
  • EPH-Like Kinase 11 3 4
  • EC 2.7.10.1 4 63
  • EHK-3 3 4
  • HEK11 3 4
  • EHK3 3 4
  • EK11 3 4
  • Receptor Protein-Tyrosine Kinase HEK11 3
  • Tyrosine-Protein Kinase Receptor EHK-3 3
  • Eph Homology Kinase-3 3
  • EC 2.7.10 63
  • EphA7 2

External Ids for EPHA7 Gene

Previous GeneCards Identifiers for EPHA7 Gene

  • GC06M093898
  • GC06M093946
  • GC06M094007
  • GC06M091169

Summaries for EPHA7 Gene

Entrez Gene Summary for EPHA7 Gene

  • This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GeneCards Summary for EPHA7 Gene

EPHA7 (EPH Receptor A7) is a Protein Coding gene. Diseases associated with EPHA7 include Gallbladder Adenocarcinoma and Mediastinal Gray Zone Lymphoma. Among its related pathways are Axon guidance and ERK Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is EPHA3.

UniProtKB/Swiss-Prot for EPHA7 Gene

  • Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.

Tocris Summary for EPHA7 Gene

Gene Wiki entry for EPHA7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHA7 Gene

Genomics for EPHA7 Gene

Regulatory Elements for EPHA7 Gene

Enhancers for EPHA7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EPHA7 on UCSC Golden Path with GeneCards custom track

Promoters for EPHA7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EPHA7 on UCSC Golden Path with GeneCards custom track

Genomic Location for EPHA7 Gene

Chromosome:
6
Start:
93,240,020 bp from pter
End:
93,419,584 bp from pter
Size:
179,565 bases
Orientation:
Minus strand

Genomic View for EPHA7 Gene

Genes around EPHA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPHA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPHA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPHA7 Gene

Proteins for EPHA7 Gene

  • Protein details for EPHA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15375-EPHA7_HUMAN
    Recommended name:
    Ephrin type-A receptor 7
    Protein Accession:
    Q15375
    Secondary Accessions:
    • A0AUX7
    • B2R8W1
    • B7ZLJ9
    • B7ZLK0
    • Q59G40
    • Q5VTU0
    • Q8N368
    • Q9H124

    Protein attributes for EPHA7 Gene

    Size:
    998 amino acids
    Molecular mass:
    112097 Da
    Quaternary structure:
    • Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain) (By similarity).
    SequenceCaution:
    • Sequence=BAD92506.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EPHA7 Gene

    Alternative splice isoforms for EPHA7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPHA7 Gene

Proteomics data for EPHA7 Gene at MOPED

Post-translational modifications for EPHA7 Gene

Other Protein References for EPHA7 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EPHA7 (EphA7)

Domains & Families for EPHA7 Gene

Suggested Antigen Peptide Sequences for EPHA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15375

UniProtKB/Swiss-Prot:

EPHA7_HUMAN :
  • Contains 1 Eph LBD (Eph ligand-binding) domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Domain:
  • Contains 1 Eph LBD (Eph ligand-binding) domain.
  • Contains 2 fibronectin type-III domains.
  • Contains 1 protein kinase domain.
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
genes like me logo Genes that share domains with EPHA7: view

Function for EPHA7 Gene

Molecular function for EPHA7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.

Enzyme Numbers (IUBMB) for EPHA7 Gene

Gene Ontology (GO) - Molecular Function for EPHA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity ISS --
GO:0005003 ephrin receptor activity IEA --
genes like me logo Genes that share ontologies with EPHA7: view
genes like me logo Genes that share phenotypes with EPHA7: view

Animal Models for EPHA7 Gene

MGI Knock Outs for EPHA7:

Animal Model Products

  • Taconic Biosciences Mouse Models for EPHA7

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EPHA7 Gene

Localization for EPHA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHA7 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPHA7 Gene COMPARTMENTS Subcellular localization image for EPHA7 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for EPHA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with EPHA7: view

Pathways & Interactions for EPHA7 Gene

genes like me logo Genes that share pathways with EPHA7: view

SIGNOR curated interactions for EPHA7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for EPHA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007411 axon guidance TAS --
GO:0016310 phosphorylation ISS --
GO:0018108 peptidyl-tyrosine phosphorylation IEA,ISS --
genes like me logo Genes that share ontologies with EPHA7: view

Drugs & Compounds for EPHA7 Gene

(3) Drugs for EPHA7 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide Experimental Pharma Target 0

(1) Additional Compounds for EPHA7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with EPHA7: view

Transcripts for EPHA7 Gene

Unigene Clusters for EPHA7 Gene

EPH receptor A7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EPHA7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - - -
SP2: - -
SP3:
SP4:

Relevant External Links for EPHA7 Gene

GeneLoc Exon Structure for
EPHA7
ECgene alternative splicing isoforms for
EPHA7

Expression for EPHA7 Gene

mRNA expression in normal human tissues for EPHA7 Gene

mRNA differential expression in normal tissues according to GTEx for EPHA7 Gene

This gene is overexpressed in Esophagus - Muscularis (x10.8), Esophagus - Gastroesophageal Junction (x7.7), and Colon - Sigmoid (x6.6).

Protein differential expression in normal tissues from HIPED for EPHA7 Gene

This gene is overexpressed in Cerebrospinal fluid (26.6), Fetal Brain (22.2), and Colon (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EPHA7 Gene



SOURCE GeneReport for Unigene cluster for EPHA7 Gene Hs.73962

mRNA Expression by UniProt/SwissProt for EPHA7 Gene

Q15375-EPHA7_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with EPHA7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for EPHA7 Gene

Orthologs for EPHA7 Gene

This gene was present in the common ancestor of animals.

Orthologs for EPHA7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EPHA7 35
  • 95.02 (n)
  • 98.2 (a)
EPHA7 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EPHA7 35
  • 96.26 (n)
  • 99.7 (a)
EPHA7 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Epha7 35
  • 91.25 (n)
  • 98.1 (a)
Epha7 16
Epha7 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC472073 35
  • 99.57 (n)
  • 99.8 (a)
EPHA7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Epha7 35
  • 91.05 (n)
  • 98.7 (a)
oppossum
(Monodelphis domestica)
Mammalia EPHA7 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EPHA7 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves EPHA7 35
  • 88.65 (n)
  • 97.99 (a)
EPHA7 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EPHA7 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia epha7 35
  • 81.93 (n)
  • 92.47 (a)
zebrafish
(Danio rerio)
Actinopterygii epha7 35
  • 76.28 (n)
  • 88.32 (a)
epha7 36
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Eph 37
  • 41 (a)
Species with no ortholog for EPHA7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EPHA7 Gene

ENSEMBL:
Gene Tree for EPHA7 (if available)
TreeFam:
Gene Tree for EPHA7 (if available)

Paralogs for EPHA7 Gene

Paralogs for EPHA7 Gene

(15) SIMAP similar genes for EPHA7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with EPHA7: view

Variants for EPHA7 Gene

Sequence variations from dbSNP and Humsavar for EPHA7 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2278107 - 93,410,921(+) TCTTA(C/T)ATTCC reference, missense
rs2278106 - 93,410,501(+) CTTAC(A/G)TTCAC reference, missense
VAR_036090 A colorectal cancer sample
VAR_042150 A colorectal adenocarcinoma sample
VAR_042151 A metastatic melanoma sample

Structural Variations from Database of Genomic Variants (DGV) for EPHA7 Gene

Variant ID Type Subtype PubMed ID
nsv517329 CNV Gain+Loss 19592680
dgv6937n71 CNV Loss 21882294
dgv6938n71 CNV Loss 21882294
nsv463971 CNV Gain 19166990
nsv470844 CNV Loss 18288195
nsv507349 CNV Insertion 20534489
esv2429821 CNV Deletion 19546169

Variation tolerance for EPHA7 Gene

Residual Variation Intolerance Score: 8.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.02; 74.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EPHA7 Gene

Human Gene Mutation Database (HGMD)
EPHA7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPHA7 Gene

Disorders for EPHA7 Gene

MalaCards: The human disease database

(7) MalaCards diseases for EPHA7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gallbladder adenocarcinoma
  • adenocarcinoma of the gallbladder
mediastinal gray zone lymphoma
  • mediastinal b-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma
mediastinal malignant lymphoma
  • lymphoma of mediastinum
brachydactyly-syndactyly syndrome
  • bdsd
syndactyly, type v
  • syndactyly type 5
- elite association - COSMIC cancer census association via MalaCards
Search EPHA7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EPHA7

Genetic Association Database (GAD)
EPHA7
Human Genome Epidemiology (HuGE) Navigator
EPHA7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EPHA7
genes like me logo Genes that share disorders with EPHA7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EPHA7 Gene

Publications for EPHA7 Gene

  1. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PMID: 9267020) (Cell 1997) 2 3 4 67
  2. Aberrant methylation of EphA7 in human prostate cancer and its relation to clinicopathologic features. (PMID: 18821581) Guan M. … Ye C. (Int. J. Cancer 2009) 3 23
  3. Increased expression of EphA7 correlates with adverse outcome in primary and recurrent glioblastoma multiforme patients. (PMID: 18366728) Wang L.F. … An H.X. (BMC Cancer 2008) 3 23
  4. ALL1 fusion proteins induce deregulation of EphA7 and ERK phosphorylation in human acute leukemias. (PMID: 17726105) Nakanishi H. … Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 23
  5. Downregulation of EphA7 by hypermethylation in colorectal cancer. (PMID: 16007213) Wang J. … Sugimura H. (Oncogene 2005) 3 23

Products for EPHA7 Gene

Sources for EPHA7 Gene

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