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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EPHA7 Gene

protein-coding   GIFtS: 70
GCID: GC06M094007

EPH Receptor A7

(Previous name: EphA7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
EPH Receptor A71 2     EphA71
EHK-32 3     Eph Homology Kinase-32
EHK32 3     Ephrin Type-A Receptor 72
EK112 3     Receptor Protein-Tyrosine Kinase HEK112
HEK112 3     Tyrosine-Protein Kinase Receptor EHK-32
EPH Homology Kinase 32 3     hEK113
EPH-Like Kinase 112 3     EC 2.7.108
EC 2.7.10.13 8     

External Ids:    HGNC: 33901   Entrez Gene: 20452   Ensembl: ENSG000001353337   OMIM: 6021905   UniProtKB: Q153753   

Export aliases for EPHA7 gene to outside databases

Previous GC identifers: GC06M093898 GC06M093946 GC06M091169


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EPHA7 Gene:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related
receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors
in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich
domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity
of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. (provided
by RefSeq, Jul 2008)

GeneCards Summary for EPHA7 Gene: 
EPHA7 (EPH receptor A7) is a protein-coding gene. Diseases associated with EPHA7 include brachydactyly-syndactyly syndrome, and gallbladder adenocarcinoma, and among its related super-pathways are Ras Pathway and MAPK Signaling. GO annotations related to this gene include protein tyrosine kinase activity and axon guidance receptor activity. An important paralog of this gene is EPHB1.

UniProtKB/Swiss-Prot: EPHA7_HUMAN, Q15375
Function: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on
adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a
cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell
adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of
corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate
brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in
activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are
phosphorylated upon activation of EPHA7

Gene Wiki entry for EPHA7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007299.13  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EPHA7 gene promoter:
         Sp1   MEF-2   STAT5A   MEF-2A   AREB6   POU2F1   Nkx6-1   POU2F1a   aMEF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEPHA7 promoter sequence
   Search SABiosciences Chromatin IP Primers for EPHA7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPHA7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q16.1   Ensembl cytogenetic band:  6q16.1   HGNC cytogenetic band: 6q16.3

EPHA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHA7 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M094007:  view genomic region     (about GC identifiers)

Start:
93,949,738 bp from pter      End:
94,129,300 bp from pter
Size:
179,563 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EPHA7_HUMAN, Q15375 (See protein sequence)
Recommended Name: Ephrin type-A receptor 7 precursor  
Size: 998 amino acids; 112097 Da
Subunit: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a
receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts
(via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain) (By similarity)
Subcellular location: Cell membrane (Probable); Single-pass type I membrane protein (Probable)
Sequence caution: Sequence=BAD92506.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
4 PDB 3D structures from and Proteopedia for EPHA7:
2REI (3D)        3DKO (3D)        3H8M (3D)        3NRU (3D)    
Secondary accessions: A0AUX7 B2R8W1 B7ZLJ9 B7ZLK0 Q59G40 Q5VTU0 Q8N368 Q9H124
Alternative splicing: 5 isoforms:  Q15375-1   Q15375-2   Q15375-3   Q15375-4   Q15375-5   (Expressed in lung cancer cells, lacks the kinase domain and is most probably secreted)

Explore the universe of human proteins at neXtProt for EPHA7: NX_Q15375

Explore proteomics data for EPHA7 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15375

  • 4/49 DME Specific Peptides for EPHA7 (Q15375) (see all 49)
     MSNQDVI  RDLAARN  QNNWLRT  CKETFNL 

    EPHA7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EPHA7 Protein Expression
    REFSEQ proteins: NP_004431.1  
    ENSEMBL proteins: 
     ENSP00000358309   ENSP00000358303  

    Human Recombinant Protein Products for EPHA7: 
    EMD Millipore Purified and/or Recombinant EPHA7 Protein
    R&D Systems Recombinant & Natural Proteins for EPHA7
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for EPHA7
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for EPHA7 
    OriGene Custom Protein Services for EPHA7
    GenScript Custom Purified and Recombinant Proteins Services for EPHA7
    Novus Biologicals EPHA7 Proteins
    Novus Biologicals EPHA7 Lysate
    Sino Biological Recombinant Protein for EPHA7
    Sino Biological Cell Lysate for EPHA7 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EPHA7 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane IEA--
    GO:0030425dendrite IEA--
    GO:0031594neuromuscular junction IEA--
    GO:0043025neuronal cell body IEA--
    GO:0045211postsynaptic membrane IEA--

    EPHA7 for ontologies           About GeneDecksing



    EPHA7 Antibody Products: 
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    Novus Biologicals EPHA7 Antibodies
    Abcam antibodies for EPHA7
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    ThermoFisher Antibodies for EPHA7
    LSBio Antibodies in human, mouse, rat for EPHA7 

    Assay Products for EPHA7: 
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    Cloud-Clone Corp. ELISAs for EPHA7 
    Cloud-Clone Corp. CLIAs for EPHA7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FN3: Fibronectin type III domain containing
    EPH: EPH receptors
    SAMD: Sterile alpha motif (SAM) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: EPH receptor A7 
    Ephrin receptor family
    Ephrin receptor family

    5/17 InterPro protein domains (see all 17):
     IPR017441 Protein_kinase_ATP_BS
     IPR003961 Fibronectin_type3
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q15375

    ProtoNet protein and cluster: Q15375

    5/6 Blocks protein domains (see all 6):
    IPB001090 Ephrin receptor
    IPB001426 Receptor tyrosine kinase
    IPB001660 Sterile alpha motif SAM
    IPB003962 Fibronectin type III repeat signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EPHA7_HUMAN, Q15375
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    EPHA7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EPHA7_HUMAN, Q15375
    Function: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on
    adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
    pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
    the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a
    cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell
    adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of
    corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate
    brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in
    activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are
    phosphorylated upon activation of EPHA7
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ISS--
    GO:0005003ephrin receptor activity ----
    GO:0005004GPI-linked ephrin receptor activity ISS--
    GO:0005515protein binding IPI--
         
    EPHA7 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for EPHA7:
     Decreased substrate adherent c  Increased cell death HMECs cel 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Epha7):
     nervous system 

    EPHA7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for EPHA7: Epha7tm1Ud Epha7tm1Jf

       inGenious Targeting Laboratory - Custom generated mouse model solutions for EPHA7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EPHA7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EPHA7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EPHA7 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EPHA7
    8/117 QIAGEN miScript miRNA Assays for microRNAs that regulate EPHA7 (see all 117):
    hsa-miR-3130-5p hsa-miR-520e hsa-miR-3938 hsa-miR-106a hsa-miR-15a hsa-miR-200a hsa-miR-138-2* hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidEPHA7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: EPHA7 (NM_004440)
    Sino Biological Human cDNA Clone for EPHA7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHA7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHA7
    Sirion Biotech Customized lentivirus for stable overexpression of EPHA7 
                         Customized lentivirus expression plasmids for stable overexpression of EPHA7 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EPHA7 About   (see all 19)                                                                                              See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    2Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    CDC42 Pathway0.41
    Actin Nucleation and Branching0.66
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for EPHA7
        Neurophysiological process Receptor-mediated axon growth repulsion
    Cell adhesion Ephrins signaling
    G-protein signaling RhoA regulation pathway

    5/32 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EPHA7 (see all 32)
        Paxillin Interactions
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    JNK Pathway
    P2Y Receptor Signaling

    3 GeneGo (Thomson Reuters) Pathways for EPHA7
        Neurophysiological process Receptor-mediated axon growth repulsion
    G-protein signaling RhoA regulation pathway
    Cell adhesion Ephrins signaling

    2 BioSystems Pathways for EPHA7
        EPHA forward signaling
    EphrinA-EPHA pathway



    1         Kegg Pathway  (Kegg details for EPHA7):
        Axon guidance


    EPHA7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EPHA7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for EPHA7 (Q153751, 2, 3 ENSP000003583094) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLLT4P551962, 3, ENSP000003836234MINT-58183 I2D: score=4 STRING: ENSP00000383623
    EFNA3P527973, ENSP000003573934I2D: score=3 STRING: ENSP00000357393
    EFNA5P528033, ENSP000003287774I2D: score=3 STRING: ENSP00000328777
    EFNA1P208273, ENSP000003573924I2D: score=2 STRING: ENSP00000357392
    EFNA2O439213, ENSP000002153684I2D: score=2 STRING: ENSP00000215368
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway ----
    GO:0007420brain development ISS--
    GO:0016310phosphorylation ISS--
    GO:0022407regulation of cell-cell adhesion ISS--

    EPHA7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EPHA7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EPHA7

    2 HMDB Compounds for EPHA7    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 DrugBank Compound for EPHA7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide-- --target--10592235

    1 Novoseek inferred chemical compound relationship for EPHA7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 43.2 1 18366728 (1)

    Search CenterWatch for drugs/clinical trials and news about EPHA7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EPHA7 gene: 
    NM_004440.3  

    Unigene Cluster for EPHA7:

    EPH receptor A7
    Hs.73962  [show with all ESTs]
    Unigene Representative Sequence: NM_004440
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369303(uc003poe.3 uc003pof.3 uc011eac.2) ENST00000369297(uc003pog.4)

    miRNA
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    hsa-miR-3130-5p hsa-miR-520e hsa-miR-3938 hsa-miR-106a hsa-miR-15a hsa-miR-200a hsa-miR-138-2* hsa-miR-93
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHA7
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPHA7

    Additional mRNA sequence: 

    AB209269.1 AK313529.1 BC027940.1 BC126125.1 BC126151.1 BC143857.1 BC143858.1 L36642.1 

    2 DOTS entries:

    DT.210496  DT.75187304 

    24/64 AceView cDNA sequences (see all 64):

    AI270413 AI949287 BM677016 NM_004440 BQ574971 BM721283 AA844326 AA661858 
    BG116505 AI653787 AA922192 AI431776 CB218864 AA843307 L36642 AU119928 
    BF439579 AA897621 BX095966 AW337703 AI375049 CD250661 AA897618 BX488164 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for EPHA7    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:                                -                 -                       -                                                                     
    SP2:                                -                 -                                                                                             
    SP3:                                                                                                                                                
    SP4:                                                                                                                                                


    ECgene alternative splicing isoforms for EPHA7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EPHA7 expression in normal human tissues (normalized intensities)      EPHA7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    EPHA7 Expression
    About this image


    EPHA7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/42 selected tissues (see all 42) fully expand
     
     Brain (Nervous System)    fully expand to see all 27 entries
             Thalamus
             Septum   
     
     Neural Tube (Nervous System)    fully expand to see all 8 entries
             Neural Fold Cells Mesencephalon
             Telencephalon
             brain/midbrain/lateral wall   
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Mesenchymal Condensate Cells Zeugopod
             Autopod
             limb/forelimb   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             rectum ; glandular cells   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Autopod Long Bone
             sensory organ/ear/inner ear   

    See EPHA7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EPHA7

    SOURCE GeneReport for Unigene cluster: Hs.73962

    UniProtKB/Swiss-Prot: EPHA7_HUMAN, Q15375
    Tissue specificity: Widely expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for EPHA7 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Epha71 , 5 Eph receptor A71, 5 91.25(n)1
    98.1(a)1
      4 (12.42 cM)5
    138411  NM_010141.31  NP_034271.31 
     288131315 
    chicken
    (Gallus gallus)
    Aves EPHA71 EPH receptor A7 88.65(n)
    97.99(a)
      395967  NM_205083.1  NP_990414.1 
    lizard
    (Anolis carolinensis)
    Reptilia EPHA76
    EPH receptor A7
    97(a)
    1 ↔ 1
    1(178427592-178647326)
    zebrafish
    (Danio rerio)
    Actinopterygii epha71 eph receptor A7 76.28(n)
    88.32(a)
      562195  NM_001044979.2  NP_001038444.2 


    ENSEMBL Gene Tree for EPHA7 (if available)
    TreeFam Gene Tree for EPHA7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EPHA7 gene
    EPHB12  EPHA22  EPHB32  EPHA42  EPHA52  EPHB62  EPHA62  EPHA12  
    EPHB22  EPHA82  EPHA32  EPHA102  EPHB42  
    15 SIMAP similar genes for EPHA7 using alignment to 2 protein entries:     EPHA7_HUMAN (see all proteins):
    EPHA3    EPHA4    EPHA6    EPHB1    EPHB2 variant protein    EPHA5
    EPHA8    EPHB2    EPHA2    EPHA10    EPHB3    EPHB4
    FYN    EPHB6    EPHA1

    EPHA7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3332 SNPs in EPHA7 are shown (see all 3332)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0421514
    A metastatic melanoma sample4--see VAR_0421512 G R mis40--------
    VAR_0421524
    A metastatic melanoma sample4--see VAR_0421522 P S mis40--------
    VAR_0421504
    A colorectal adenocarcinoma sample4--see VAR_0421502 E K mis40--------
    VAR_0360904
    A colorectal cancer sample4--see VAR_0360902 R W mis40--------
    rs125265011,2
    H--93949298(+) ATTCAA/CCCAGA 1 -- ds50010--------
    rs121538971,2
    F--93949349(+) TGATCC/TAGTAA 1 -- ds50010--------
    rs3457401,2
    C,F,H--93949370(+) AAAAAA/CATCTA 1 -- ds50017Minor allele frequency- C:0.10NS EA WA 542
    rs1915931141,2
    --93949404(+) TTAAAA/GTATAT 1 -- ds50010--------
    rs1827458201,2
    --93949485(+) GGAAGA/GAGCAA 1 -- ds50010--------
    rs1175525061,2
    C,F--93949706(+) GGGATA/GTAAAG 1 -- ds50011Minor allele frequency- G:0.01NA 120

    HapMap Linkage Disequilibrium report for EPHA7 (93949738 - 94129300 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for EPHA7:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2429821CNV Deletion19546169
    nsv507349CNV Insertion20534489
    dgv6938n71CNV Loss21882294
    dgv6937n71CNV Loss21882294
    nsv470844CNV Loss18288195
    nsv463971CNV Gain19166990
    nsv517329CNV Gain+Loss19592680


    Human Gene Mutation Database (HGMD): EPHA7
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602190    OMIM disorders: --

    20/23 diseases for EPHA7 (see all 23):    About MalaCards
    brachydactyly-syndactyly syndrome    gallbladder adenocarcinoma    syndactyly    brachydactyly
    follicular lymphoma    skin cancer    pancreatic ductal adenocarcinoma    acute leukemia
    adenocarcinoma    glioblastoma    hepatitis c    retinitis
    cerebritis    colorectal cancer    pancreatitis    lung cancer
    prostate cancer    prostatitis    leukemia    endotheliitis


    EPHA7 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for EPHA7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 16596241 (2), 18366728 (1)
    cancer 0 2 18821581 (1), 16596241 (1)

    Genetic Association Database (GAD): EPHA7
    Human Genome Epidemiology (HuGE) Navigator: EPHA7 (2 documents)

    Export disorders for EPHA7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EPHA7 gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with EPHA7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PubMed id 9267020)1, 2, 3 (1997)
    2. ALL1 fusion proteins induce deregulation of EphA7 and ERK phosphorylation in human acute leukemias. (PubMed id 17726105)1, 2, 9 Nakanishi H....Croce C.M. (2007)
    3. Secreted form of EphA7 in lung cancer. (PubMed id 20126984)1, 2 Tsuboi M....Sugimura H. (2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    7. cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. (PubMed id 7898931)1, 2 Fox G.M.... Welcher A.A. (1995)
    8. Aberrant methylation of EphA7 in human prostate cancer and its relation to clinicopathologic features. (PubMed id 18821581)1, 9 Guan M....Ye C. (2009)
    9. Increased expression of EphA7 correlates with adverse outcome in primary and recurrent glioblastoma multiforme patients. (PubMed id 18366728)1, 9 Wang L.F....An H.X. (2008)
    10. Downregulation of EphA7 by hypermethylation in colorectal cancer. (PubMed id 16007213)1, 9 Wang J....Sugimura H. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2045 HGNC: 3390 AceView: EPHA7 Ensembl:ENSG00000135333 euGenes: HUgn2045
    ECgene: EPHA7 Kegg: 2045 H-InvDB: EPHA7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EPHA7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EPHA7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EPHA7 gene:
    Search GeneIP for patents involving EPHA7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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