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Aliases for EPHA7 Gene

Aliases for EPHA7 Gene

  • EPH Receptor A7 2 3
  • EPH Homology Kinase 3 3 4
  • EPH-Like Kinase 11 3 4
  • EC 2.7.10.1 4 64
  • EHK-3 3 4
  • HEK11 3 4
  • EHK3 3 4
  • EK11 3 4
  • Receptor Protein-Tyrosine Kinase HEK11 3
  • Tyrosine-Protein Kinase Receptor EHK-3 3
  • Ephrin Type-A Receptor 7 3
  • Eph Homology Kinase-3 3
  • EC 2.7.10 64
  • EphA7 2

External Ids for EPHA7 Gene

Summaries for EPHA7 Gene

Entrez Gene Summary for EPHA7 Gene

  • This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GeneCards Summary for EPHA7 Gene

EPHA7 (EPH Receptor A7) is a Protein Coding gene. Diseases associated with EPHA7 include brachydactyly-syndactyly syndrome and syndactyly, type v. Among its related pathways are GPCR Pathway and Akt Signaling. GO annotations related to this gene include protein tyrosine kinase activity and axon guidance receptor activity. An important paralog of this gene is EPHB3.

UniProtKB/Swiss-Prot for EPHA7 Gene

  • Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.

Gene Wiki entry for EPHA7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHA7 Gene

Genomics for EPHA7 Gene

Genomic Location for EPHA7 Gene

Start:
93,240,020 bp from pter
End:
93,419,584 bp from pter
Size:
179,565 bases
Orientation:
Minus strand

Genomic View for EPHA7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EPHA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPHA7 Gene

Regulatory Elements for EPHA7 Gene

Proteins for EPHA7 Gene

  • Protein details for EPHA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15375-EPHA7_HUMAN
    Recommended name:
    Ephrin type-A receptor 7
    Protein Accession:
    Q15375
    Secondary Accessions:
    • A0AUX7
    • B2R8W1
    • B7ZLJ9
    • B7ZLK0
    • Q59G40
    • Q5VTU0
    • Q8N368
    • Q9H124

    Protein attributes for EPHA7 Gene

    Size:
    998 amino acids
    Molecular mass:
    112097 Da
    Quaternary structure:
    • Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain) (By similarity).
    SequenceCaution:
    • Sequence=BAD92506.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EPHA7 Gene

    Alternative splice isoforms for EPHA7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPHA7 Gene

Proteomics data for EPHA7 Gene at MOPED

Post-translational modifications for EPHA7 Gene

Other Protein References for EPHA7 Gene

Domains for EPHA7 Gene

Gene Families for EPHA7 Gene

HGNC:
  • SAMD :Sterile alpha motif (SAM) domain containing
  • FN3 :Fibronectin type III domain containing
  • EPH :EPH receptors
IUPHAR :

UniProtKB/Swiss-Prot:

EPHA7_HUMAN
Domain:
  • Contains 1 Eph LBD (Eph ligand-binding) domain.:
    • Q15375
  • Contains 2 fibronectin type-III domains.:
    • Q15375
  • Contains 1 protein kinase domain.:
    • Q15375
  • Contains 1 SAM (sterile alpha motif) domain.:
    • Q15375
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.:
    • Q15375
genes like me logo Genes that share domains with EPHA7: view

Function for EPHA7 Gene

Molecular function for EPHA7 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.

Enzyme Numbers (IUBMB) for EPHA7 Gene

Gene Ontology (GO) - Molecular Function for EPHA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity ISS --
GO:0005003 ephrin receptor activity --
GO:0005004 GPI-linked ephrin receptor activity ISS --
GO:0005515 protein binding IPI 22036564
genes like me logo Genes that share ontologies with EPHA7: view

Phenotypes for EPHA7 Gene

genes like me logo Genes that share phenotypes with EPHA7: view

Animal Models for EPHA7 Gene

MGI Knock Outs for EPHA7:

No data available for Transcription Factor Targeting and HOMER Transcription for EPHA7 Gene

Localization for EPHA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHA7 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPHA7 Gene COMPARTMENTS Subcellular localization image for EPHA7 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for EPHA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0030425 dendrite IEA --
GO:0031594 neuromuscular junction IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with EPHA7: view

Pathways for EPHA7 Gene

genes like me logo Genes that share pathways with EPHA7: view

Pathways by source for EPHA7 Gene

Gene Ontology (GO) - Biological Process for EPHA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway --
GO:0007411 axon guidance TAS --
GO:0007420 brain development ISS --
GO:0016310 phosphorylation ISS --
genes like me logo Genes that share ontologies with EPHA7: view

Compounds for EPHA7 Gene

(2) HMDB Compounds for EPHA7 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(1) Drugbank Compounds for EPHA7 Gene

(1) Novoseek inferred chemical compound relationships for EPHA7 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 43.2 1
genes like me logo Genes that share compounds with EPHA7: view

Transcripts for EPHA7 Gene

Unigene Clusters for EPHA7 Gene

EPH receptor A7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EPHA7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - - -
SP2: - -
SP3:
SP4:

Relevant External Links for EPHA7 Gene

GeneLoc Exon Structure for
EPHA7
ECgene alternative splicing isoforms for
EPHA7

Expression for EPHA7 Gene

mRNA expression in normal human tissues for EPHA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EPHA7 Gene

This gene is overexpressed in Esophagus - Muscularis (10.8), Esophagus - Gastroesophageal Junction (7.7), and Colon - Sigmoid (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EPHA7 Gene

SOURCE GeneReport for Unigene cluster for EPHA7 Gene Hs.73962

mRNA Expression by UniProt/SwissProt for EPHA7 Gene

Q15375-EPHA7_HUMAN
Tissue specificity: Widely expressed
genes like me logo Genes that share expressions with EPHA7: view

Orthologs for EPHA7 Gene

This gene was present in the common ancestor of animals.

Orthologs for EPHA7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EPHA7 37
  • 100 (a)
OneToOne
LOC472073 36
  • 99.57 (n)
  • 99.8 (a)
cow
(Bos Taurus)
Mammalia EPHA7 36
  • 95.02 (n)
  • 98.2 (a)
EPHA7 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EPHA7 36
  • 96.26 (n)
  • 99.7 (a)
EPHA7 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Epha7 36
  • 91.25 (n)
  • 98.1 (a)
Epha7 16
Epha7 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EPHA7 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EPHA7 37
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Epha7 36
  • 91.05 (n)
  • 98.7 (a)
chicken
(Gallus gallus)
Aves EPHA7 36
  • 88.65 (n)
  • 97.99 (a)
EPHA7 37
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EPHA7 37
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia epha7 36
  • 81.93 (n)
  • 92.47 (a)
zebrafish
(Danio rerio)
Actinopterygii epha7 36
  • 76.28 (n)
  • 88.32 (a)
epha7 37
  • 86 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Eph 38
  • 41 (a)
Species with no ortholog for EPHA7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EPHA7 Gene

ENSEMBL:
Gene Tree for EPHA7 (if available)
TreeFam:
Gene Tree for EPHA7 (if available)

Paralogs for EPHA7 Gene

Paralogs for EPHA7 Gene

Selected SIMAP similar genes for EPHA7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with EPHA7: view

Variants for EPHA7 Gene

Sequence variations from dbSNP and Humsavar for EPHA7 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs766 -- 93,347,426(+) TTAAG(C/G)GTTTT intron-variant
rs163945 -- 93,315,189(+) AAATG(C/T)ATTAA intron-variant
rs163995 -- 93,328,422(-) TATTT(A/T)TTCAG intron-variant
rs163996 -- 93,327,709(-) tgaat(A/C)cattt intron-variant
rs164289 -- 93,313,383(+) ATGAA(A/G)AGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EPHA7 Gene

Variant ID Type Subtype PubMed ID
nsv517329 CNV Gain+Loss 19592680
dgv6937n71 CNV Loss 21882294
dgv6938n71 CNV Loss 21882294
nsv463971 CNV Gain 19166990
nsv470844 CNV Loss 18288195
nsv507349 CNV Insertion 20534489
esv2429821 CNV Deletion 19546169

Relevant External Links for EPHA7 Gene

HapMap Linkage Disequilibrium report
EPHA7
Human Gene Mutation Database (HGMD)
EPHA7

Disorders for EPHA7 Gene

(2) Novoseek inferred disease relationships for EPHA7 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 3
cancer 0 2

Relevant External Links for EPHA7

Genetic Association Database (GAD)
EPHA7
Human Genome Epidemiology (HuGE) Navigator
EPHA7
genes like me logo Genes that share disorders with EPHA7: view

No data available for UniProtKB/Swiss-Prot for EPHA7 Gene

Publications for EPHA7 Gene

  1. ALL1 fusion proteins induce deregulation of EphA7 and ERK phosphorylation in human acute leukemias. (PMID: 17726105) Nakanishi H. … Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4 23
  2. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PMID: 9267020) (Cell 1997) 2 3 4
  3. cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. (PMID: 7898931) Fox G.M. … Welcher A.A. (Oncogene 1995) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Increased expression of EphA7 correlates with adverse outcome in primary and recurrent glioblastoma multiforme patients. (PMID: 18366728) Wang L.F. … An H.X. (BMC Cancer 2008) 3 23

Products for EPHA7 Gene

  • Addgene plasmids for EPHA7

Sources for EPHA7 Gene

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