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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EPHA7 Gene

protein-coding   GIFtS: 68
GCID: GC06M094007

EPH receptor A7

(Previous name: EphA7 )
 Explore 20 diseases affiliated with
EPHA7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for EPHA7    

Aliases
for EPHA7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
EPH Receptor A71 2     EphA71
EHK-32 3     Hek111
EHK32 3     Eph Homology Kinase-32
EK112 3     Ephrin Type-A Receptor 72
HEK112 3     Receptor Protein-Tyrosine Kinase HEK112
EPH Homology Kinase 32 3     Tyrosine-Protein Kinase Receptor EHK-32
EPH-Like Kinase 112 3     HEK112 3
EC 2.7.10.13 8     EC 2.7.108

External Ids:    HGNC: 33901   Entrez Gene: 20452   Ensembl: ENSG000001353337   OMIM: 6021905   UniProtKB: Q153753   

Export aliases for EPHA7 gene to outside databases

Previous GC identifers: GC06M093898 GC06M093946 GC06M091169


Summaries
for EPHA7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for EPHA7:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors
have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH
subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2
fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their
extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: EPHA7_HUMAN, Q15375
Function: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent
cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream
of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is
referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7
and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent
activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic
mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent
proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including
MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7

Gene Wiki entry for EPHA7


Genomic Views
for EPHA7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007299.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EPHA7 gene promoter:
         Sp1   MEF-2   STAT5A   MEF-2A   AREB6   POU2F1   Nkx6-1   POU2F1a   aMEF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EPHA7 promoter sequence
   Search SABiosciences Chromatin IP Primers for EPHA7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPHA7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q16.1   Ensembl cytogenetic band:  6q16.1   HGNC cytogenetic band: 6q16.3

EPHA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHA7 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M094007:  view genomic region     (about GC identifiers)

Start:
 93,949,738 bp from pter      End:
 94,129,300 bp from pter
Size:
 179,563 bases      Orientation:
 minus strand

Proteins
for EPHA7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: EPHA7_HUMAN, Q15375 (See protein sequence)
Recommended Name: Ephrin type-A receptor 7 precursor  
Size: 998 amino acids; 112097 Da
Subunit: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor
dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via PDZ-binding
motif) with GRIP1 and PICK1 (via PDZ domain) (By similarity)
Subcellular location: Cell membrane (Probable); Single-pass type I membrane protein (Probable)
Sequence caution: Sequence=BAD92506.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
4 PDB 3D structures from and Proteopedia for EPHA7:
2REI (3D)        3DKO (3D)        3H8M (3D)        3NRU (3D)    
Secondary accessions: A0AUX7 B2R8W1 B7ZLJ9 B7ZLK0 Q59G40 Q5VTU0 Q8N368 Q9H124
Alternative splicing: 5 isoforms:  Q15375-1   Q15375-2   Q15375-3   Q15375-4   Q15375-5   (Expressed in lung cancer cells, lacks the kinase domain and is most probably secreted)

Explore the universe of human proteins at neXtProt for EPHA7: NX_Q15375

Post-translational modifications:

  • Phosphorylated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15375

    • 4/49 DME Specific Peptides for EPHA7 (Q15375) (see all 49)
     MSNQDVI  RDLAARN  QNNWLRT  CKETFNL 

    EPHA7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004431.1  
    ENSEMBL proteins: 
     ENSP00000358309   ENSP00000358303  

    Human Recombinant Protein Products: 
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    Novus Biologicals EPHA7 Proteins
    Novus Biologicals EPHA7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for EPHA7

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane IEA--
    GO:0030425dendrite IEA--
    GO:0031594neuromuscular junction IEA--
    GO:0043025neuronal cell body IEA--
    GO:0045211postsynaptic membrane IEA--


    EPHA7 for ontologies           About GeneDecksing



    EPHA7 Antibody Products: 
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    Uscn Antibodies for EPHA7
    ThermoFisher Antibodies for EPHA7

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    Uscn ELISAs and CLIAs for EPHA7

    Protein Domains /
    Families
    for EPHA7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    EPHA7 for domains           About GeneDecksing

    5/17 InterPro domains/families (see all 17):
     IPR017441 Protein_kinase_ATP_BS
     IPR003961 Fibronectin_type3
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q15375

    ProtoNet protein and cluster: Q15375

    5/6 Blocks protein families (see all 6):
    IPB001090 Ephrin receptor
    IPB001426 Receptor tyrosine kinase
    IPB001660 Sterile alpha motif SAM
    IPB003962 Fibronectin type III repeat signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EPHA7_HUMAN, Q15375
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Function
    for EPHA7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: EPHA7_HUMAN, Q15375
    Function: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent
    cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream
    of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is
    referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7
    and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent
    activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic
    mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent
    proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including
    MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

    Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EPHA7
    8/117 QIAGEN miScript miRNA Assays for microRNAs that regulate EPHA7 (see all 117):
    hsa-miR-3130-5p hsa-miR-520e hsa-miR-3938 hsa-miR-106a hsa-miR-15a hsa-miR-200a hsa-miR-138-2* hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: EPHA7 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EPHA7 (see all 7)
    OriGene shRNA RFP: EPHA7
    OriGene siRNA: EPHA7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPHA7

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for EPHA7

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EPHA7 (see all 6)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: EPHA7 (NM_004440)
    Sino Biological Human cDNA Clone for EPHA7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHA7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHA7 

    Cell Line
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    Search LifeMap BioReagents cell lines for EPHA7

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA7

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004713protein tyrosine kinase activity ISS--
    GO:0005004GPI-linked ephrin receptor activity ISS--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0008046axon guidance receptor activity ISS--


    EPHA7 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for EPHA7:
     Decreased substrate adherent c  Increased cell death HMECs cel 

    Animal Models:
         Mouse knock-outs for EPHA7: Epha7tm1Ud Epha7tm1Jf
         1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Epha7):
     nervous system 

    EPHA7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for EPHA7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    		P2Y Receptor Signaling0.38
    2Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    3Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		14-3-3 Induced Intracellular Signaling0.59
    		GSK3 Signaling0.61
    		eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    		Actin Nucleation by ARP-WASP Complex1.00
    		CDC42 Pathway0.34
    		Actin Nucleation and Branching0.66
    5G-protein signaling_RhoA regulation pathway
    		G-protein signaling_RhoA regulation pathway1.00
    		EphrinA-EphR Signaling0.26
    		G-protein signaling RhoA regulation pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for EPHA7
        Neurophysiological process Receptor-mediated axon growth repulsion
    Cell adhesion Ephrins signaling
    G-protein signaling RhoA regulation pathway

    5/32 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EPHA7 (see all 32)
        Paxillin Interactions
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    JNK Pathway
    P2Y Receptor Signaling

    3 GeneGo (Thomson Reuters) Pathways for EPHA7
        Neurophysiological process Receptor-mediated axon growth repulsion
    G-protein signaling RhoA regulation pathway
    Cell adhesion Ephrins signaling

    2 BioSystems Pathways for EPHA7 
        EPHA forward signaling
    EphrinA-EPHA pathway


    1         Kegg Pathway  (Kegg details for EPHA7):
        Axon guidance


    EPHA7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EPHA7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for EPHA7 (Q153751, 2, 3 ENSP000003583094) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLLT4P551962, 3, ENSP000003836234MINT-58183 I2D: score=4 STRING: ENSP00000383623
    EFNA3P527973, ENSP000003573934I2D: score=3 STRING: ENSP00000357393
    EFNA5P528033, ENSP000003287774I2D: score=3 STRING: ENSP00000328777
    EFNA1P208273, ENSP000003573924I2D: score=2 STRING: ENSP00000357392
    EFNA2O439213, ENSP000002153684I2D: score=2 STRING: ENSP00000215368
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007411axon guidance ----
    GO:0007420brain development ISS--
    GO:0016310phosphorylation ISS--
    GO:0022407regulation of cell-cell adhesion ISS--
    GO:0031290retinal ganglion cell axon guidance IEA--


    EPHA7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for EPHA7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EPHA7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EPHA7

    2 HMDB Compounds for EPHA7    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 DrugBank Compound for EPHA7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide-- --target--10592235

    1 Novoseek chemical compound relationship for EPHA7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 43.2 1 18366728 (1)

    Search CenterWatch for drugs/clinical trials and news about EPHA7 

    Transcripts
    for EPHA7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for EPHA7 gene: 
    NM_004440.3  

    Unigene Cluster for EPHA7:

    EPH receptor A7
    Hs.73962  [show with all ESTs]
    Unigene Representative Sequence: NM_004440
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369303(uc003poe.3 uc003pof.3 uc011eac.2) ENST00000369297(uc003pog.4)


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    hsa-miR-3130-5p hsa-miR-520e hsa-miR-3938 hsa-miR-106a hsa-miR-15a hsa-miR-200a hsa-miR-138-2* hsa-miR-93
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    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPHA7

    Additional cDNA sequence: 

    AB209269.1 AK313529.1 BC027940.1 BC126125.1 BC126151.1 BC143857.1 BC143858.1 L36642.1 

    2 DOTS entries:

    DT.210496  DT.75187304 

    24/64 AceView cDNA sequences (see all 64):

    AA661858 AI653787 AA844326 BG116505 BM721283 BM677016 NM_004440 AI949287 
    AI270413 AI431776 AA922192 BQ574971 AI801963 BM718400 BX492253 BX452205 
    AI204065 BM683457 BI753142 AI743069 AI089165 BC027940 BF982716 AL699163 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for EPHA7    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:                                -                 -                       -                                                                     
    SP2:                                -                 -                                                                                             
    SP3:                                                                                                                                                
    SP4:                                                                                                                                                


    ECgene alternative splicing isoforms for EPHA7

    Expression
    for EPHA7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EPHA7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    EPHA7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeMesencephalonNeural Fold CellsNeural Ectoderm
    Neural TubeProsencephalonNeural Fold CellsNeural Ectoderm
    Neural TubeRhombencephalonNeural Fold CellsNeural Ectoderm
    PancreasIslets of LangerhansMature Beta CellsPancreas
    BoneAutopod Long BoneBone
    BrainHypothalamusBrain
    KidneyMetanephrosKidney
    LimbAutopodLimb
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See EPHA7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EPHA7

    SOURCE GeneReport for Unigene cluster: Hs.73962

    UniProtKB/Swiss-Prot: EPHA7_HUMAN, Q15375
    Tissue specificity: Widely expressed

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    Orthologs
    for EPHA7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for EPHA7 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves EPHA71 EPH receptor A7 88.65(n)
    97.99(a)    		   395967  NM_205083.1  NP_990414.1 
    lizard
    (Anolis carolinensis)    		 Reptilia EPHA76
    		 --
    		 93(a)
    		 possible ortholog
    		 1(178449919-178646965)
    zebrafish
    (Danio rerio)    		 Actinopterygii epha71 eph receptor A7 76.28(n)
    88.32(a)    		   562195  NM_001044979.2  NP_001038444.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Eph3 protein amino acid phosphorylation
    transmembrane more    		 41(a)   102C2   --
    worm
    (Caenorhabditis elegans)    		 Secernentea vab-16
    Y116A8C.386
    (see all 6)    		 --
    		 28(a)
    18(a)
    (see all 6)    		 possible ortholog
    possible ortholog
    (see all 6)    		 II(4571997-4591357)
    IV(17131509-17137510)


    ENSEMBL Gene Tree for EPHA7 (if available)
    TreeFam Gene Tree for EPHA7 (if available) 

    Paralogs
    for EPHA7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EPHA7 gene
    EPHB12  EPHA22  EPHB32  EPHA42  EPHA52  EPHB62  EPHA62  EPHB22  
    EPHA12  EPHA82  EPHA32  EPHB42  EPHA102  
    15 SIMAP similar genes for EPHA7 using alignment to 2 protein entries:     EPHA7_HUMAN (see all proteins):
    EPHA3    EPHA4    EPHA6    EPHB1    EPHB2 variant protein    EPHA5
    EPHA8    EPHB2    EPHA2    EPHA10    EPHB3    EPHB4
    FYN    EPHB6    EPHA1

    EPHA7 for paralogs           About GeneDecksing



    Genomic Variants
    for EPHA7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2859 NCBI SNPs in EPHA7 are shown (see all 2859)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs125265011,2
    		H--93949298(+) ATTCAA/CCCAGA 1 -- ds50010--------
    rs121538971,2
    		--93949349(+) TGATCC/TAGTAA 1 -- ds50010--------
    rs3457401,2
    		C,F,H,--93949370(+) AAAAAA/CATCTA 1 -- ds50017Minor allele frequency- C:0.10NS EA WA 542
    rs1915931141,2
    		--93949404(+) TTAAAA/GTATAT 1 -- ds50010--------
    rs1827458201,2
    		--93949485(+) GGAAGA/GAGCAA 1 -- ds50010--------
    rs1175525061,2
    		--93949706(+) GGGATA/GTAAAG 1 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1871684201,2
    		--93949765(+) ACTTGC/TTTATT 1 -- ut310--------
    rs1900160971,2
    		--93949863(+) GTTTGC/TCCTTA 1 -- ut310--------
    rs1823088721,2
    		--93950119(+) AAACAC/TGGATA 1 -- ut310--------
    rs10481771,2
    		C,F,O,A,H,--93950120(-) TTATCC/TGTGTT 1 -- ut31 ese329Minor allele frequency- T:0.45MN NA NS EA WA CSA 3094

    HapMap Linkage Disequilibrium report for EPHA7 (93949738 - 94129300 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for EPHA7
         2 CNVs: 99628 93895
    Human Gene Mutation Database (HGMD): EPHA7

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    Disorders / Diseases
    for EPHA7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    EPHA7 for disorders           About GeneDecksing

    OMIM gene information: 602190    OMIM disorders: --

    20 diseases for EPHA7:    About MalaCards
    brachydactyly-syndactyly syndrome    syndactyly    brachydactyly    pancreatic ductal adenocarcinoma
    follicular lymphoma    skin cancer    acute leukemia    colorectal cancer
    lung cancer    adenocarcinoma    prostate cancer    pancreatitis
    glioblastoma    leukemia    cerebritis    retinitis
    prostatitis    neuronitis    carcinoma    breast cancer

    1 disease from the University of Copenhagen DISEASES database for EPHA7:
    Gallbladder adenocarcinoma

    2 Novoseek disease relationships for EPHA7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 16596241 (2), 18366728 (1)
    cancer 0 2 18821581 (1), 16596241 (1)

    Human Genome Epidemiology (HuGE) Navigator: EPHA7 (2 documents)

    Export disorders for EPHA7 gene to outside databases

    Publications
    for EPHA7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EPHA7 gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with EPHA7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PubMed id 9267020)1, 2, 3 (1997)
    2. ALL1 fusion proteins induce deregulation of EphA7 and ERK phosphorylation in human acute leukemias. (PubMed id 17726105)1, 2, 9 Nakanishi H....Croce C.M. (2007)
    3. Secreted form of EphA7 in lung cancer. (PubMed id 20126984)1, 2 Tsuboi M....Sugimura H. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. (PubMed id 7898931)1, 2 Fox G.M.... Welcher A.A. (1995)
    7. Aberrant methylation of EphA7 in human prostate cancer and its relation to clinicopathologic features. (PubMed id 18821581)1, 9 Guan M....Ye C. (2009)
    8. Increased expression of EphA7 correlates with adverse outcome in primary and recurrent glioblastoma multiforme patients. (PubMed id 18366728)1, 9 Wang L.F....An H.X. (2008)
    9. Downregulation of EphA7 by hypermethylation in colorectal cancer. (PubMed id 16007213)1, 9 Wang J....Sugimura H. (2005)
    10. Serum ferritin levels are associated with a distinct p henotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy. (PubMed id 22095909)1 Lange C.M....Bochud P.Y. (2012)

    External Searches for EPHA7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing EPHA7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2045 HGNC: 3390 AceView: EPHA7 Ensembl:ENSG00000135333 euGenes: HUgn2045
    ECgene: EPHA7 Kegg: 2045 H-InvDB: EPHA7

    Other Databases showing EPHA7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing EPHA7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EPHA7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EPHA7 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for EPHA7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for EPHA7 gene:
    Search GeneIP for patents involving EPHA7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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