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EPHA5 Gene

protein-coding   GIFtS: 67
GCID: GC04M066193

EPH Receptor A5

(Previous name: EphA5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
EPH Receptor A51 2     EC 2.7.10.13 8
HEK72 3 5     EphA51
TYRO42 3 5     CEK72
Brain-Specific Kinase2 3     Ephrin Type-A Receptor 52
EHK-12 3     Receptor Protein-Tyrosine Kinase HEK72
EHK12 3     Tyrosine-Protein Kinase Receptor EHK-12
EK72 3     BSK3
EPH Homology Kinase 12 3     hEK73
EPH-Like Kinase 72 3     EC 2.7.108

External Ids:    HGNC: 33891   Entrez Gene: 20442   Ensembl: ENSG000001452427   OMIM: 6000045   UniProtKB: P547563   

Export aliases for EPHA5 gene to outside databases

Previous GC identifers: GC04U990011 GC04M066173 GC04M066014 GC04M065872 GC04M062095


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EPHA5 Gene:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related
receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors
in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich
domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity
of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
Alternatively spliced transcript variants encoding different isoforms have been described. (provided by RefSeq,
Aug 2013)

GeneCards Summary for EPHA5 Gene:
EPHA5 (EPH receptor A5) is a protein-coding gene. Diseases associated with EPHA5 include drug psychosis, and pancreatic ductal adenocarcinoma. GO annotations related to this gene include GPI-linked ephrin receptor activity and transmembrane-ephrin receptor activity. An important paralog of this gene is EPHB1.

UniProtKB/Swiss-Prot: EPHA5_HUMAN, P54756
Function: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on
adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably
constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development
and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways.
Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis.
Beside its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between
pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity)

Gene Wiki entry for EPHA5 (EPH receptor A5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EPHA5 gene promoter:
         C/EBPbeta   p53   Pbx1a   ATF-2   Nkx2-2   CRE-BP1   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEPHA5 promoter sequence
   Search Chromatin IP Primers for EPHA5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EPHA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.1   Ensembl cytogenetic band:  4q13.1   HGNC cytogenetic band: 4q13.1

EPHA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHA5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M066193:  view genomic region     (about GC identifiers)

Start:
66,185,281 bp from pter      End:
66,536,213 bp from pter
Size:
350,933 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EPHA5_HUMAN, P54756 (See protein sequence)
Recommended Name: Ephrin type-A receptor 5 precursor  
Size: 1037 amino acids; 114803 Da
Subunit: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a
receptor dimer. Oligomerization is probably required to induce biological responses (By similarity)
2 PDB 3D structures from and Proteopedia for EPHA5:
2R2P (3D)        4ET7 (3D)    
Secondary accessions: Q7Z3F2
Alternative splicing: 3 isoforms:  P54756-1   P54756-2   P54756-3   

Explore the universe of human proteins at neXtProt for EPHA5: NX_P54756

Explore proteomics data for EPHA5 at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation is stimulated by the ligand EFNA5. Dephosphorylation upon stimulation by glucose,
    inhibits EPHA5 forward signaling and results in insulin secretion (By similarity)1
  • Glycosylation2 at Asn264, Asn299, Asn369, Asn423, Asn436, Asn461
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for EPHA5 (P54756) (see all 49)
     RDLAARN  DTGGRKD  YVFQIRA  EEGYRLP 


    See EPHA5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001268694.1  NP_001268695.1  NP_001268696.1  NP_004430.4  NP_872272.2  

    ENSEMBL proteins: 
     ENSP00000273854   ENSP00000389208   ENSP00000346899   ENSP00000427638  

    EPHA5 Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for EPHA5
    Cloud-Clone Corp. CLIAs for EPHA5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    EPH: EPH receptors
    SAMD: Sterile alpha motif (SAM) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: EPH receptor A5
    Ephrin receptor family
    Ephrin receptor family

    Selected InterPro protein domains (see all 16):
     IPR017441 Protein_kinase_ATP_BS
     IPR003961 Fibronectin_type3
     IPR021129 SAM_type1
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P54756

    ProtoNet protein and cluster: P54756

    5 Blocks protein domains:
    IPB001090 Ephrin receptor
    IPB001426 Receptor tyrosine kinase
    IPB001660 Sterile alpha motif SAM
    IPB003962 Fibronectin type III repeat signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EPHA5_HUMAN, P54756
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    EPHA5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EPHA5_HUMAN, P54756
    Function: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on
    adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
    pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
    the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably
    constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development
    and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways.
    Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis.
    Beside its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between
    pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity)
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0005003ephrin receptor activity ISS--
    GO:0005004GPI-linked ephrin receptor activity ISS--
    GO:0005005transmembrane-ephrin receptor activity NAS7898931
         
    EPHA5 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Epha5):
     nervous system 

    EPHA5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for EPHA5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EPHA5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EPHA5

    miRNA
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    Block miRNA regulation of human, mouse, rat EPHA5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EPHA5 (see all 99):
    hsa-miR-323-3p hsa-miR-520e hsa-miR-4272 hsa-miR-106a hsa-miR-200a hsa-miR-605 hsa-miR-938 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidEPHA5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat EPHA5

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): EPHA5 (NM_004439)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHA5

    Cell Line
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    PureStem E15, Meso-prx/latp Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EPHA5_HUMAN, P54756: Cell membrane (By similarity); Single-pass type I membrane protein (By similarity). Cell
    projection, axon (By similarity). Cell projection, dendrite
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    cytosol1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005791rough endoplasmic reticulum IDA10375373
    GO:0005886plasma membrane IDA10375373
    GO:0005887integral component of plasma membrane IEA--
    GO:0009897external side of plasma membrane IDA10064801
    GO:0016021integral component of membrane ----

    EPHA5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EPHA5 About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.41
    Actin Nucleation by ARP-WASP Complex0.66
    5EPHA forward signaling
    EphrinA-EPHA pathway0.00
    Ephrin A reverse signaling0.00
    EPHA forward signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EPHA5 (see all 32)
        Paxillin Interactions
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    JNK Pathway
    P2Y Receptor Signaling

    1 Cell Signaling Technology (CST) Pathway for EPHA5
        Tyrosine Kinases / Adaptors

    3 GeneGo (Thomson Reuters) Pathways for EPHA5
        Neurophysiological process Receptor-mediated axon growth repulsion
    G-protein signaling RhoA regulation pathway
    Cell adhesion Ephrins signaling

    3 BioSystems Pathways for EPHA5
        EPHA forward signaling
    Ephrin A reverse signaling
    EphrinA-EPHA pathway


    1 Kegg Pathway  (Kegg details for EPHA5):
        Axon guidance


    EPHA5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EPHA5
    Interactions:

        Search GeneGlobe Interaction Network for EPHA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EPHA5 (P547563 ENSP000002738544) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EFNA2O439213, ENSP000002153684I2D: score=2 STRING: ENSP00000215368
    EFNA5P528033, ENSP000003287774I2D: score=2 STRING: ENSP00000328777
    EFNA1P208273, ENSP000003573924I2D: score=1 STRING: ENSP00000357392
    EFNA3P527973, ENSP000003573934I2D: score=1 STRING: ENSP00000357393
    STAT3P407633, ENSP000002646574I2D: score=1 STRING: ENSP00000264657
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway ----
    GO:0007411axon guidance ISS--
    GO:0019933cAMP-mediated signaling ISS--
    GO:0021766hippocampus development ISS--

    EPHA5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EPHA5

    2 HMDB Compounds for EPHA5    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 Novoseek inferred chemical compound relationship for EPHA5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 31.9 2 10064801 (1), 19733895 (1)



    EPHA5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for EPHA5 gene (5 alternative transcripts): 
    NM_001281765.1  NM_001281766.1  NM_001281767.1  NM_004439.6  NM_182472.3  

    Unigene Cluster for EPHA5:

    EPH receptor A5
    Hs.654492  [show with all ESTs]
    Unigene Representative Sequence: NM_004439
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273854(uc003hcx.3 uc003hcy.3 uc003hcz.3 uc011cah.2 uc011cai.2)
    ENST00000432638 ENST00000354839 ENST00000511294(uc003hda.2)
    miRNA
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    hsa-miR-323-3p hsa-miR-520e hsa-miR-4272 hsa-miR-106a hsa-miR-200a hsa-miR-605 hsa-miR-938 hsa-miR-519a
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat EPHA5

    Additional mRNA sequence: 

    AB209375.1 AK307826.1 BC136257.1 BC136258.1 BC143427.1 BX537946.1 L36644.1 

    4 DOTS entries:

    DT.65287326  DT.95152379  DT.407663  DT.95153288 

    Selected AceView cDNA sequences (see all 27):

    BM693322 BX642416 BX102577 AI867137 BE219686 BF433558 BX477839 H11658 
    BM664168 BE218107 D82015 AA121200 AV718336 D81888 AI697835 BX505546 
    T06040 T07343 AI694040 BG925074 AW341789 NM_182472 H12187 NM_004439 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    EPHA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    EPHA5 Expression
    About this image


    EPHA5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Pancreas (Endocrine System)
             Mature Beta Cells Islets of Langerhans
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Peripheral Nervous System (Nervous System)
             Immature Schwann Cells Peripheral Nerve Domain
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor
    EPHA5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    EPHA5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654492

    UniProtKB/Swiss-Prot: EPHA5_HUMAN, P54756
    Tissue specificity: Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje
    cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from
    the forebrain to hindbrain and spinal cord

        Custom PCR Arrays for EPHA5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for EPHA5 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Epha51 , 5 Eph receptor A51, 5 90.39(n)1
    96.24(a)1
      5 (43.00 cM)5
    138391  NM_007937.31  NP_031963.21 
     840577915 
    chicken
    (Gallus gallus)
    Aves EPHA51 EPH receptor A5 83.9(n)
    93.53(a)
      395997  NM_205105.2  NP_990436.2 
    lizard
    (Anolis carolinensis)
    Reptilia EPHA56
    EPH receptor A5
    93(a)
    1 ↔ 1
    GL343345.1(579409-856437)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia epha51 EPH receptor A5 78.14(n)
    86.68(a)
      100488002  XM_002936460.2  XP_002936506.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7975951 ephrin type-A receptor 5-like 72.52(n)
    79.67(a)
      797595  XM_001338028.5  XP_001338064.4 


    ENSEMBL Gene Tree for EPHA5 (if available)
    TreeFam Gene Tree for EPHA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for EPHA5 gene
    EPHB12  EPHA22  EPHB32  EPHA42  EPHB62  EPHA62  EPHA12  EPHB22  
    EPHA82  EPHA32  EPHA72  EPHA102  EPHB42  
    Selected SIMAP similar genes for EPHA5 using alignment to 5 protein entries:     EPHA5_HUMAN (see all proteins) (see all similar genes):
    EPHA3    EPHA4    EPHA6    EPHA7    EPHB1    EPHB2
    ABL1    EPHA8    EPHB2 variant protein    EPHA2    EPHB3    FGR
    FES    tec    EPHA10    FYN    SRC    MET

    EPHA5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for EPHA5 (see all 7811)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0421434
    A lung adenocarcinoma sample4--see VAR_0421432 G E mis40--------
    VAR_0421484
    A lung large cell carcinoma sample4--see VAR_0421482 N S mis40--------
    VAR_0421424
    A lung large cell carcinoma sample4--see VAR_0421422 E K mis40--------
    VAR_0421414
    A lung adenocarcinoma sample4--see VAR_0421412 R Q mis40--------
    VAR_0421464
    A lung squamous cell carcinoma sample4--see VAR_0421462 T I mis40--------
    rs58589651,2
    C--62308692(+) TACAG-/T/TT  
            
    TTTTT
    2 -- int10--------
    rs712054021,2
    C--62432188(+) AAAAA-/A/AAA 
            
    GTCCC
    2 -- int11NA 2
    rs58589801,2
    C--62435386(+) aaaaa-/AAAAAA/AAAAAAAA
    AA
    /AAAAAAAAAAAAAAA
    CAGGA
    6 -- int1 cds11NA 2
    rs1811157901,2
    --66184833(+) GACACA/GATACT 2 -- ds50010--------
    rs726402351,2
    --66184947(+) TTGGGC/TTGATG 2 -- ds50010--------
    rs790817281,2
    C,F--66185042(+) ATCAAC/TTTCTA 2 -- ds50014Minor allele frequency- T:0.07NA EA 244
    rs37495261,2
    C,F,A,H--66185198(-) TAACAA/TTGTTT 2 -- ds500127Minor allele frequency- T:0.44NS EA NA CSA WA 2748
    rs623130341,2
    F--66185222(+) AAAACG/ATTACA 2 -- ds50011Minor allele frequency- A:0.50NA 2
    rs777722251,2
    F--66185260(+) AGAGGG/TTCAAG 2 -- ds50011Minor allele frequency- T:0.06EA 120
    rs1881622671,2
    --66185384(+) CAAATA/GAGAAA 2 -- ut310--------
    rs1809659801,2
    --66185642(+) CACTGA/GAACTT 2 -- ut310--------
    rs764554161,2
    C,F--66185715(+) ATTAAC/TGTTTA 2 -- ut311Minor allele frequency- T:0.04EA 120
    rs1465179231,2
    --66185716(+) TTAACA/GTTTAG 2 -- ut310--------
    rs1491039181,2
    --66185728(+) AGAAAA/CAAACA 2 -- ut310--------
    rs801698351,2
    C,F--66185815(+) GTGGTC/AATTCT 2 -- ut313Minor allele frequency- A:0.13NA 124
    rs1871246661,2
    --66185870(+) AAATGA/GATAAG 2 -- ut310--------
    rs1925102991,2
    --66185888(+) AAGAAA/TGTTCC 2 -- ut310--------
    rs1821462001,2
    --66185935(+) CACAAC/TAGAGA 2 -- ut310--------
    rs48606481,2
    C,F--66186017(+) ATAAAG/ACTAGC 2 -- ut315Minor allele frequency- A:0.18NA EA 246
    rs1412810631,2
    C--66186042(+) ATTCT-/TCATCATC 2 -- cds10--------
    rs105382731,2
    C--66186043(+) ATTCT-/TCAtcatc 2 -- cds10--------
    rs48606491,2
    C,F,A--66186119(+) AAACAT/CCTGGC 2 -- ut318Minor allele frequency- C:0.15NA WA EA 496
    rs113762331,2
    C--66186159(+) ACTTC-/TTTTTT 2 -- ut310--------
    rs1131781981,2
    F--66186336(+) AGAACT/CCACTT 2 -- ut311Minor allele frequency- C:0.00CSA 1
    rs1905704911,2
    --66186386(+) CACATA/GCAGAT 2 -- ut310--------
    rs1824346231,2
    --66186485(+) TTACAC/TTGGTC 2 -- ut310--------
    rs1871120361,2
    --66186491(+) TGGTCA/GAAACT 2 -- ut310--------
    rs1896601161,2
    --66186592(+) GGAATA/GTAATT 2 -- ut310--------
    rs738242781,2
    C,F--66186781(+) CAAGAT/CTAGAA 2 -- ut312Minor allele frequency- C:0.10WA 120
    rs1482941961,2
    C--66186814(+) AGTAAC/TTGAGT 2 -- ut310--------
    rs769250011,2
    F--66186880(+) AATACT/GGTGAA 2 -- ut311Minor allele frequency- G:0.01WA 118
    rs1830147811,2
    --66186908(+) GATATC/TGCTAC 2 -- ut310--------
    rs1887587881,2
    --66186925(+) TTACAA/GTAAGA 2 -- ut310--------
    rs1405115191,2
    --66186990(+) TTATTG/TTTGGT 2 -- ut310--------
    rs1452547691,2
    C--66187011(+) GTGAC-/AAAATG 2 -- ut310--------
    rs738242791,2
    C,F--66187099(+) GAGTTG/AGCTCC 2 -- ut312Minor allele frequency- A:0.08WA 120
    rs738242811,2
    C,F--66187100(+) AGTTGG/CCTCCT 2 -- ut312Minor allele frequency- C:0.10WA 120
    rs1470621491,2
    C--66187118(+) TTCCAC/TTTCTC 2 -- ut310--------
    rs1932058731,2
    --66187169(+) ATACAA/TTAGGA 2 -- ut310--------
    rs1156707921,2
    F--66187205(+) TTCCTC/TTTTTT 2 -- ut311Minor allele frequency- T:0.05WA 118
    rs1855897161,2
    --66187289(+) AACCAA/TATTGA 2 -- ut310--------
    rs789531821,2
    C--66187299(+) AGATGC/TAAAAG 2 -- ut310--------
    rs1117486961,2
    C,F--66187329(+) ACTTTC/TCTTTC 2 -- ut311Minor allele frequency- T:0.50NA 2
    rs1440044771,2
    C--66187475(+) CACCCA/GGACCT 2 -- ut310--------
    rs48606501,2
    C,F,A,H--66187627(+) TCTCAA/GTTGTT 2 -- ut3128Minor allele frequency- G:0.12NA NS EA WA CSA 2473
    rs1922379201,2
    --66187809(+) TTCACA/GTCTCT 2 -- ut310--------
    rs285801391,2
    C--66187824(+) ATTTTA/GCTAAA 2 -- ut310--------
    rs795341741,2
    C,F--66188049(+) GTGCTA/CATATT 2 -- ut312Minor allele frequency- C:0.12WA NA 238
    rs1840682081,2
    --66188160(+) TTAACA/GTTGAT 2 -- ut310--------
    rs1888041501,2
    --66188264(+) GTTGGA/TTATCT 2 -- ut310--------
    rs48606511,2
    C,F,A,H--66188295(+) ATTTCT/CAATAC 2 -- ut3130Minor allele frequency- C:0.20EA NA NS CSA WA 3402
    rs1808179851,2
    --66188338(+) CATCAC/TGTGTG 2 -- ut310--------
    rs1842707031,2
    --66188469(+) CAAATG/TAATAA 2 -- ut310--------
    rs738242821,2
    C,F--66188521(+) TTCTGA/GAGGGA 2 -- ut313Minor allele frequency- G:0.10WA NA 240
    rs749721381,2
    F--66188537(+) GCATAT/CATATA 2 -- ut311Minor allele frequency- C:0.03WA 118
    rs101553271,2
    C,A--66188645(+) TACAAA/CGGATT 2 -- ut310--------
    rs14511841,2
    C,F,O,H--66188672(-) TAGCAG/CGAAGC 2 -- ut3191Minor allele frequency- C:0.41NS EA NA PA EU CA WA CSA 4678
    rs345098141,2
    C,F,H--66188753(+) CCCTTC/TGGTGT 2 -- ut3118Minor allele frequency- T:0.07NS EA NA WA 2340
    rs1494220431,2
    --66188766(+) ACTTTG/TCTTGA 2 -- ut310--------
    rs1892170741,2
    --66188830(+) TAATGA/GCTAGA 2 -- ut310--------
    rs800503731,2
    C,F--66188984(+) GTTTTA/GCTGCT 2 -- ut311Minor allele frequency- G:0.05EA 120
    rs1822622641,2
    --66189157(+) ATACAC/GTATAT 2 -- ut310--------
    rs76887951,2
    C,F,A,H--66189260(+) TTGATG/CAAGCA 2 -- ut3126Minor allele frequency- C:0.20NA NS EA WA CSA 2485
    rs342464621,2
    C--66189395(+) AAGAC-/TTGAAGT 2 -- ut310--------
    rs1863666411,2
    --66189465(+) CAAGTA/GGATCC 2 -- ut310--------
    rs1888564391,2
    C--66189607(+) CATGTA/CCCTTT 2 -- ut310--------
    rs1115372751,2
    C--66189753(+) CCCCCT/-TTTTT 2 -- ut311Minor allele frequency- -:0.50CSA 2
    rs770621371,2
    C--66189755(+) CCCCTC/TTTTTT 2 -- ut311Minor allele frequency- T:0.50NA 2
    rs1438950901,2
    C--66189775(+) AATCTC/TAGTGC 2 -- ut310--------
    rs1118160561,2
    C--66189816(+) AGAAGC/TGACAT 2 -- ut311Minor allele frequency- T:0.50CSA 2
    rs1995575441,2
    --66189820(+) GCGACA/GTTTAC 2 -- ut310--------
    rs557847411,2
    C,F--66189835(+) AGTTAC/TAATGG 4 L syn12Minor allele frequency- T:0.01NA EU 5847
    rs2005256131,2
    C--66189846(+) CACCAT/ATCCGT 4 /M /L mis11Minor allele frequency- A:0.00EU 1323
    rs1397936741,2
    C--66189849(+) CATTCC/TGTTTA 4 R G mis11Minor allele frequency- T:0.00NA 4524
    rs1902960171,2
    C--66189862(+) AGCTGC/TACCTT 4 V syn10--------
    rs560371971,2
    C,F--66189880(+) TGAAGG/ACTGTT 4 /S syn12Minor allele frequency- A:0.00NA EU 5843
    rs1410889851,2
    C--66189883(+) AGGCTG/ATTCAT 4 /N syn11Minor allele frequency- A:0.00NA 4520
    rs1433117581,2
    C--66189928(+) AGCCGT/CCTCAA 4 /R syn11Minor allele frequency- C:0.00NA 4510
    rs76773921,2
    H--66190076(+) GTTTTT/AAAAGG 2 -- int14Minor allele frequency- A:0.00NS EA 410
    rs18688481,2
    C,F,A,H--66190191(-) TGCACC/TACTAA 2 -- int112Minor allele frequency- T:0.08NS EA NA WA 936
    rs30572791,2
    C--66190283(+) GATTTGCAGA   
       TTT
    /-
    ACAAT
    2 -- int11Minor allele frequency- -:0.00NA 2
    rs105179311,2
    C,F,H--66190304(+) ACTTAT/ATTTTG 2 -- int115Minor allele frequency- A:0.18NS NA EA 898
    rs1171569111,2
    F--66190309(+) TTTTTG/ACTAAA 2 -- int11Minor allele frequency- A:0.01EA 120
    rs18688471,2
    C,F,A,H--66190432(-) TGTAGT/CGGTGA 2 -- int122Minor allele frequency- C:0.06NS EA NA WA 2352
    rs755934001,2
    F--66190505(+) AATTTT/GTTTTT 2 -- int11Minor allele frequency- G:0.07NA 120
    rs1830099921,2
    --66190551(+) GCATGA/CTGAAT 2 -- int10--------
    rs1859183121,2
    --66190593(+) GATACC/TTCTGT 2 -- int10--------
    rs1438517131,2
    C--66190601(+) GTGCA-/TTTTTT 2 -- int10--------
    rs13494521,2
    C,H--66190634(-) TGTAAT/ATTTAT 2 -- int111Minor allele frequency- A:0.04NA WA CSA EA 377
    rs344128571,2
    F--66190639(+) ATTACA/GAATAT 2 -- int12Minor allele frequency- G:0.12WA NA 238
    rs101550731,2
    C,F--66190644(+) AAATAT/CTTAGA 2 -- int14Minor allele frequency- C:0.13WA NA 242
    rs1908422331,2
    --66190657(+) TCTAAA/GCTAAC 2 -- int10--------
    rs1839306671,2
    --66190705(+) TTCAAC/TGTTCT 2 -- int10--------
    rs1391472291,2
    --66190715(+) TTTTAC/TAGGAT 2 -- int10--------
    rs360370481,2
    C,F--66190745(+) CTAAAG/ATATGT 2 -- int14Minor allele frequency- A:0.08NA WA 242
    rs1441083201,2
    C--66190774(+) GCAAAA/TGATAA 2 -- int10--------
    rs1879951891,2
    --66190790(+) AATTAA/TAGGAA 2 -- int10--------
    rs757375621,2
    F--66190817(+) ATTCAA/GAATCC 2 -- int11Minor allele frequency- G:0.01EA 120
    rs1920871341,2
    --66190877(+) ATTGAA/TCACAT 2 -- int10--------
    rs1509743981,2
    --66191052(+) AGAAAC/TTAAAG 2 -- int10--------
    rs1409000951,2
    --66191093(+) GAAATA/TTTTTT 2 -- int10--------
    rs361159751,2
    C,F--66191096(+) ATATTT/GTTTTC 2 -- int14Minor allele frequency- G:0.05NA WA 242
    rs1831734861,2
    --66191158(+) GACAGC/TTTTAG 2 -- int10--------
    rs801532751,2
    C--66191181(+) AGCTA-/CCCCCC 2 -- int10--------
    rs1404189691,2
    C--66191187(+) AAAAA-/ATGCTA 2 -- int10--------
    rs105179321,2
    C,F,H--66191236(+) TTAGAA/TTGTGA 2 -- int113Minor allele frequency- T:0.06NS EA NA 776
    rs73564021,2
    C,F,A,H--66191356(+) AAAATT/CAGTAA 2 -- int117Minor allele frequency- C:0.11NS EA NA WA 2222
    rs1497389271,2
    --66191382(+) AAAATC/TATTAT 2 -- int10--------
    rs2008777811,2
    C--66191383(+) AAATCA/GTTATT 2 -- int10--------
    rs754416531,2
    C,F--66191601(+) TTGGCC/GTCTGC 2 -- int14Minor allele frequency- G:0.12NA WA 242
    rs1875301891,2
    --66191609(+) TGCCCA/GCTATA 2 -- int10--------
    rs732142411,2
    C--66191652(+) ATTTTT/AACAAG 2 -- int15Minor allele frequency- A:0.22WA CSA NA EA 361
    rs359999821,2
    C--66191746(+) TATATAT/-CTCAT 2 -- int11Minor allele frequency- -:0.00NA 2
    rs1161605701,2
    C,F--66191754(+) CATATA/GTATAT 2 -- int12Minor allele frequency- G:0.15WA NA 238
    rs1928378531,2
    --66191756(+) TATATA/GTATGT 2 -- int10--------
    rs1848497111,2
    --66191940(+) AAACAA/CAGGCT 2 -- int10--------
    rs177505991,2
    C,F,H--66192081(+) GCACTT/CCAAAT 2 -- int18Minor allele frequency- C:0.05NA NS EA 682
    rs14707361,2
    C,F,A,H--66192122(-) ACAGGG/ATTCTC 2 -- int112Minor allele frequency- A:0.10NS EA NA WA CSA 787
    rs1893567011,2
    --66192315(+) ATGGGC/TGTTCA 2 -- int10--------
    rs1924329521,2
    --66192506(+) AATATA/GTATGC 2 -- int10--------
    rs100065411,2
    C,F,A,H--66192541(+) TATGTT/GAATTA 2 -- int118Minor allele frequency- G:0.09NA NS EA WA CSA 924
    rs743953431,2
    C,F--66192604(+) AATGAC/TCTGAA 2 -- int12Minor allele frequency- T:0.12CSA NA 122
    rs45089461,2
    C,F,A,H--66192715(+) AAGGAT/GATCAA 2 -- int125Minor allele frequency- G:0.30NS EA NA CSA WA 2748
    rs14707351,2
    C,H--66192771(-) TTTTTA/CTCTAA 2 -- int110Minor allele frequency- C:0.11NA WA CSA EA 372
    rs13494511,2
    C,H--66192793(-) ATATCC/TAGAAG 2 -- int18Minor allele frequency- T:0.12NA WA EA 368
    rs13494501,2
    C,A,H--66192795(-) TCATAG/TCTAGA 2 -- int19Minor allele frequency- T:0.11NA WA CSA EA 369
    rs340170951,2
    C--66192839(+) GTTTCG/AGTAGT 2 -- int14Minor allele frequency- A:0.08NA WA 242
    rs13494491,2
    C,F,A,H--66192883(-) TCTCAT/CAATTC 2 -- int112Minor allele frequency- C:0.37NS EA NA WA 740
    rs340105151,2
    C,F--66192914(+) TGTGGG/TTATTG 2 -- int15Minor allele frequency- T:0.07NA WA 244
    rs1846491081,2
    --66193141(+) CTCATC/TCTAAA 2 -- int10--------
    rs1457351041,2
    --66193203(+) AAGTAC/TTGCCA 2 -- int10--------
    rs1894880171,2
    --66193227(+) CTCCCA/CTGAAA 2 -- int10--------
    rs1489273061,2
    --66193324(+) TAATGC/TATGCA 2 -- int10--------
    rs170860651,2
    C,F,H--66193332(+) GCAACG/CTACAT 2 -- int112Minor allele frequency- C:0.22NA NS EA WA CSA 918
    rs1815504351,2
    --66193628(+) TGGTCA/GTCTTA 2 -- int10--------
    rs283998731,2
    C,F--66193714(+) AATAAT/CTTGGA 2 -- int14Minor allele frequency- C:0.13NA WA 242
    rs772163681,2
    C,F--66193751(+) TTTCAT/CTTTTC 2 -- int12Minor allele frequency- C:0.07WA NA 238
    rs1470260491,2
    --66193878(+) ATAACA/GAATTA 2 -- int10--------
    rs170860701,2
    C,F,H--66193917(+) CATGAC/TGAGAC 2 -- int113Minor allele frequency- T:0.35NA NS EA CSA 810
    rs758342331,2
    C,F--66194061(+) AACAAT/CGGAAA 2 -- int11Minor allele frequency- C:0.06WA 118
    rs1384008011,2
    --66194116(+) TAATAA/CAAAGT 2 -- int10--------
    rs284894591,2
    --66194146(+) CAACTA/CTTAAT 2 -- int10--------
    rs1467972351,2
    C--66194190(+) TTCATG/TCTCTT 2 -- int10--------
    rs44920481,2
    H--66194219(+) TACTTT/CACACA 2 -- int14Minor allele frequency- C:0.00NS EA 402
    rs1483472671,2
    --66194285(+) AGGGAG/TAAGAC 2 -- int10--------
    rs1153794001,2
    C,F--66194323(+) ATATTT/GATTGC 2 -- int11Minor allele frequency- G:0.01NA 120
    rs58589471,2
    C,F--66194367(+) TGTCA-/T/TT  
            
    TTTTT
    2 -- int1 trp34NA CSA 8
    rs43628771,2
    C,F,H--66194446(+) TTGGCA/CAGAAG 2 -- int122Minor allele frequency- C:0.24NS EA NA WA CSA 2482
    rs1415918951,2
    --66194546(+) TTTAAG/TGGTAT 2 -- int10--------
    rs18688461,2
    C,F,A,H--66194591(-) AATAGT/ATTTAT 2 -- int114Minor allele frequency- A:0.34NS EA NA CSA WA 670
    rs74379711,2
    C,F,H--66194608(+) AATCTG/ATAAAG 2 -- int111Minor allele frequency- A:0.21NS EA NA WA CSA 770
    rs131067411,2
    C,F,H--66194739(+) ATTTTG/CCTCAT 2 -- int19Minor allele frequency- C:0.05NS EA NA WA 780
    rs1509020001,2
    --66194774(+) GTACTG/TATACG 2 -- int10--------
    rs732142481,2
    C,F--66194778(+) TGATAC/TGAAAA 2 -- int11Minor allele frequency- T:0.50WA 2
    rs1900215101,2
    --66194780(+) ATACGA/GAAATA 2 -- int10--------
    rs1811475101,2
    --66194928(+) GCCACA/GATTGT 2 -- int10--------
    rs126436611,2
    C,F,H--66195039(+) CTCTCA/CGACCT 2 -- int19Minor allele frequency- C:0.19NA EA 390
    rs1864608401,2
    --66195356(+) CAATAA/GCTCTA 2 -- int10--------
    rs43896231,2
    H--66195415(+) TTAGGT/GATGGG 2 -- int14Minor allele frequency- G:0.00NS EA 404
    rs1909338091,2
    --66195480(+) TCTTTC/TGCTGA 2 -- int10--------
    rs58589501,2
    C--66195528(+) CTGAC-/T/TT  
            
    TTTTT
    2 -- int1 trp31NA 2
    rs21227221,2
    C,F,O,A,H--66195601(-) TACTTT/GCTTGG 2 -- int126Minor allele frequency- G:0.37NS EA NA WA 2896
    rs738242841,2
    C,F--66195631(+) TAACAT/CAATGT 2 -- int12Minor allele frequency- C:0.10WA 120
    rs1415348601,2
    --66195827(+) TACTAC/TAGACA 2 -- int10--------
    rs1461746571,2
    --66195876(+) CCCAAC/TGTAAC 2 -- int10--------
    rs1392129111,2
    --66195938(+) GGCAAA/TCTAGC 2 -- int10--------
    rs1424377681,2
    --66195953(+) GGCCAC/TAAGCT 2 -- int10--------
    rs341138231,2
    C,F--66195982(+) GAAGAC/AATAAG 2 -- int17Minor allele frequency- A:0.09NA WA EA 366
    rs1440666621,2
    --66196038(+) GGATAG/TAGGAG 2 -- int10--------
    rs665527061,2
    C--66196062(+) AAAAA-/AGGAAT 2 -- int12Minor allele frequency- A:0.25NA 4
    rs13764251,2
    C,F,H--66196175(-) AATTAT/AAGTTT 2 -- int19Minor allele frequency- A:0.27NS EA WA CSA NA 764
    rs1119777031,2
    C,F--66196187(+) GTAATC/TATAAC 2 -- int11Minor allele frequency- T:0.50WA 2
    rs670430491,2
    C--66196223(+) TGTAGT/CAGATG 2 -- int15Minor allele frequency- C:0.27WA CSA NA EA 362
    rs76869491,2
    C,F,A,H--66196275(+) ACATTG/ATTTAA 2 -- int111Minor allele frequency- A:0.32NS EA NA CSA WA 772
    rs1486629931,2
    --66196322(+) ACATTA/GGGTAG 2 -- int10--------
    rs76889411,2
    C,F,A,H--66196622(+) GTTATC/AGGTAT 2 -- int120Minor allele frequency- A:0.29NS EA NA CSA WA 2334
    rs48606521,2
    C,F,A,H--66196635(+) AGGAAA/GAGAAT 2 -- int1 trp322Minor allele frequency- N:0.00EA NA NS CSA WA 2452
    rs21673251,2
    C,F,O,H--66196706(-) ATTCAC/TTGTTC 2 -- int117Minor allele frequency- T:0.08NS NA WA CSA EA 636
    rs111315931,2
    H--66196725(+) TCAAAG/AAATGT 2 -- int14Minor allele frequency- A:0.00NS EA 416
    rs76731911,2
    C,F,A--66196764(+) CTGCTC/TAATGT 2 -- int111Minor allele frequency- T:0.32NA CSA WA EA 510
    rs357643471,2
    C--66196777(+) ATATC-/ATGTGTA 2 -- int10--------
    rs1864011321,2
    --66196778(+) TATCAC/TGTGTA 2 -- int10--------
    rs119432621,2
    C,F,H--66196838(+) TCTAAA/TCCTTA 2 -- int115Minor allele frequency- T:0.28NA NS EA WA CSA 926
    rs1422429641,2
    --66197019(+) ACAAAA/CAACTT 2 -- int10--------
    rs1912094991,2
    --66197070(+) ATTTAA/GTAAGG 2 -- int10--------
    rs1158906201,2
    C,F--66197097(+) TTAAAC/TGTGCA 2 -- int11Minor allele frequency- T:0.03WA 118
    rs1834091951,2
    --66197146(+) CAAATA/CACAAA 2 -- int10--------
    rs795656871,2
    F--66197160(+) GAGGCG/AGGATC 2 -- int11Minor allele frequency- A:0.11WA 118
    rs1874076261,2
    --66197175(+) ACATCC/TTTAGA 2 -- int10--------
    rs1122939711,2
    F--66197201(+) GTGCAC/TCATTT 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs119387531,2
    C,F,H--66197269(+) TTCATC/TGTAGA 2 -- int138Minor allele frequency- T:0.27NA NS EA WA CSA 3692
    rs119476291,2
    C,F,H--66197329(+) CAATTG/TTGCTT 2 -- int129Minor allele frequency- T:0.27NA NS EA WA CSA 2670
    rs1512249821,2
    C--66197657(+) CCCAGA/CAATTA 2 -- int10--------
    rs1397199511,2
    C--66197662(+) CAATTA/GTGTAA 2 -- int10--------
    rs1831921791,2
    C--66197706(+) CCTGAA/GCCACA 4 A V mis10--------
    rs1881167591,2
    C--66197714(+) ACAGCA/GTCCAT 4 D syn10--------
    rs744873291,2
    C--66197721(+) CCATTA/GAACTG 4 S L mis10--------
    rs73496831,2
    C,F,A,H--66197804(+) TAGGCC/TCCAGA 4 G syn1 ese326Minor allele frequency- T:0.29NA NS EA CSA WA EU 8337
    rs563129311,2,,4
    C--66197823(+) GGCTAC/TGTTCT 4 H R mis10--------
    rs1926920491,2
    --66198008(+) AAATAC/GAGGAG 2 -- int10--------
    rs76788881,2
    C,F,A,H--66198059(+) AATGAA/GGACTT 2 -- int125Minor allele frequency- G:0.48NS EA NA CSA WA 2755
    rs1837961831,2
    --66198121(+) AAAAAA/TTTTAT 2 -- int10--------
    rs774060361,2
    F--66198192(+) TAATGG/TTGGAC 2 -- int11Minor allele frequency- T:0.10WA 118
    rs1866686931,2
    --66198201(+) ACACAC/TTTGTC 2 -- int10--------
    rs13764241,2
    C,F,A,H--66198227(-) TTGGTT/GGTGTA 2 -- int110Minor allele frequency- G:0.36NS EA WA CSA NA 782
    rs13764231,2
    A--66198334(-) CCCACC/GACCCC 2 -- int10--------
    rs13764221,2
    C,F,A--66198336(-) CCCCCA/CCCACC 2 -- int13Minor allele frequency- C:0.33WA NA EA 358
    rs13764211,2
    C,F,H--66198379(-) TCCCAC/AGTACT 2 -- int116Minor allele frequency- A:0.10NS EA NA WA CSA 794
    rs1847595121,2
    --66198508(+) AAATGC/TTACCC 2 -- int10--------
    rs124990071,2
    H--66198520(+) CTATAA/GCTATG 2 -- int10--------
    rs777014521,2
    F--66198567(+) GAGGAA/TCTTAT 2 -- int11Minor allele frequency- T:0.10WA 118
    rs108661571,2
    C,F,A,H--66198650(+) TTACAC/GTTTTA 2 -- int18Minor allele frequency- G:0.31NS EA NA WA 778
    rs1901275651,2
    --66198657(+) TTTACA/GTAGAG 2 -- int10--------
    rs1818407631,2
    --66198756(+) CAATAC/GACACT 2 -- int10--------
    rs119458731,2
    C,F,H--66198874(+) AAGGAA/GACTAA 2 -- int120Minor allele frequency- G:0.27NS EA NA WA CSA 2342
    rs1424705211,2
    --66198903(+) ATGCCC/TATTAT 2 -- int10--------
    rs119458861,2
    C,F,H--66198921(+) TACATA/GATTTA 2 -- int15Minor allele frequency- G:0.28NA WA EA 366
    rs1162080451,2
    C,F--66198989(+) CTCTCT/CACTCA 2 -- int11Minor allele frequency- C:0.02WA 118
    rs1848152171,2
    --66199020(+) ATTCCA/C/GTTTAC 2 -- int10--------
    rs1502138491,2
    --66199029(+) ACCCTG/TGAGTA 2 -- int10--------
    rs1897470291,2
    --66199033(+) TTGAGG/TATAGT 2 -- int10--------
    rs1121383201,2
    F--66199070(+) TACTCC/TAGTTG 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs1458388821,2
    --66199097(+) CTCTTC/TTGCCA 2 -- int10--------
    rs1851575151,2
    --66199128(+) AACTAC/TAAAAT 2 -- int10--------
    rs1899188641,2
    --66199173(+) TACCAC/TCTCCC 2 -- int10--------
    rs170860891,2
    C,F--66199196(+) AAATCT/CTACTC 2 -- int110Minor allele frequency- C:0.27NA WA CSA EA 506
    rs76872681,2
    C,F,A,H--66199234(+) GTGTGT/CGTGTG 2 -- int112Minor allele frequency- C:0.49EA NS NA CSA WA 667
    rs100191181,2
    C--66199257(+) TGTGTG/CTGTGT 2 -- int12Minor allele frequency- C:0.25WA 4
    rs569252031,2
    C--66199286(+) GTGTG-/TGTGT 
     GTGTGTG
    CTGGA
    2 -- int11Minor allele frequency- TGTGTGTGTGTG:0.00NA 2
    rs764097861,2
    C,F--66199317(+) ATCTCC/TTTTGC 2 -- int11Minor allele frequency- T:0.04EA 120
    rs1818399331,2
    --66199513(+) TATGCC/TTATTT 2 -- int10--------
    rs1873313371,2
    --66199523(+) TTGTAC/TCTCCA 2 -- int10--------
    rs1917767631,2
    --66199591(+) GTGTGC/TTCTTG 2 -- int10--------
    rs284311851,2
    C,F--66199711(+) ACAGCC/TGACCA 2 -- int16Minor allele frequency- T:0.14NA WA 246
    rs287604701,2
    C,F--66199730(+) CCATTC/GAATAT 2 -- int16Minor allele frequency- G:0.14NA WA 246
    rs1489831551,2
    --66199992(+) AGATGC/TTGGAT 2 -- int10--------
    rs738221031,2
    C,F--66200009(+) ATGAAT/CATGTT 2 -- int12Minor allele frequency- C:0.10WA 120
    rs1437381051,2
    --66200011(+) GAATAC/TGTTAT 2 -- int10--------
    rs1481727611,2
    --66200012(+) AATATA/GTTATA 2 -- int10--------
    rs1153562371,2
    F--66200100(+) TTGAAG/ATTATG 2 -- int11Minor allele frequency- A:0.01WA 118
    rs664960701,2
    C,F--66200101(+) TGAAGT/CTATGA 2 -- int17Minor allele frequency- C:0.28NA WA CSA EA 366
    rs1430253211,2
    --66200118(+) TGCAAC/TTTTGA 2 -- int10--------
    rs68518281,2
    C,F,H--66200170(+) aaggtC/Agattt 2 -- int117Minor allele frequency- A:0.12NS EA NA WA 2112
    rs674471871,2
    C--66200189(+) AATCAT/CTGAAG 2 -- int15Minor allele frequency- C:0.22WA CSA NA EA 362
    rs1155896681,2
    F--66200209(+) TCAAGA/TTATTT 2 -- int11Minor allele frequency- T:0.03WA 118
    rs1836053301,2
    --66200212(+) AGATAC/TTTAGA 2 -- int10--------
    rs1882560311,2
    --66200277(+) GTAGGC/GATGGA 2 -- int10--------
    rs1909992941,2
    --66200281(+) GGATGC/GAGAAA 2 -- int10--------
    rs114493241,2
    C--66200283(+) TGGAG-/AAAAGG 2 -- int1 trp30--------
    rs778578741,2
    C,F--66200329(+) GTCAGG/TATATG 2 -- int11Minor allele frequency- T:0.10WA 118
    rs68522621,2
    C,F,H--66200337(+) ATGCAC/GATGAC 2 -- int123Minor allele frequency- N:0.00NS EA NA WA CSA 1308
    rs100336651,2
    C,F,H--66200389(+) GCAAAA/CTTTGT 2 -- int14Minor allele frequency- C:0.01NS EA 406
    rs1825552001,2
    --66200419(+) CTGAAA/TCCTAT 2 -- int10--------
    rs767879041,2
    C,F--66200440(+) CAATGA/GAATAA 2 -- int11Minor allele frequency- G:0.03WA 118
    rs1865366801,2
    --66200448(+) TAAGAA/CAATTA 2 -- int10--------
    rs1913660691,2
    --66200458(+) ATTTAG/TAAATT 2 -- int10--------
    rs1378710541,2
    --66200509(+) TTAATA/GTAATT 2 -- int10--------
    rs348781481,2
    C--66200523(+) AACAT-/AAGTTTT 2 -- int11Minor allele frequency- AA:0.00NA 2
    rs2005085921,2
    --66200525(+) ATAAG-/TTTTTT 2 -- int10--------
    rs99994651,2
    C,F,H--66200548(+) TGTACG/ATCCAT 2 -- int110Minor allele frequency- A:0.14NS EA NA 802
    rs1846214931,2
    --66200691(+) TTTGCC/TACCAC 2 -- int10--------
    rs676684791,2
    C,F--66200749(+) TGTATT/CTAAAA 2 -- int14Minor allele frequency- C:0.09NA WA 242
    rs748244171,2
    C,F--66200824(+) AATTGT/GTTCTC 2 -- int11Minor allele frequency- G:0.06EA 120
    rs100249481,2
    C,F,H--66200829(+) TTTCTC/TATTTA 2 -- int17Minor allele frequency- T:0.13NS EA NA 652
    rs100018691,2
    C,F--66200835(+) ATTTAG/TTCCAT 2 -- int11Minor allele frequency- T:0.01WA 118
    rs170821151,2
    C,F,H--66200842(+) CCATGT/CTAATA 2 -- int113Minor allele frequency- C:0.47NA NS EA CSA WA 905
    rs2007073111,2
    C--66200996(+) AAAAC-/AGAA  
            
    AGGCA
    2 -- int10--------
    rs1889005701,2
    --66201048(+) GTGCTA/GTTCAG 2 -- int10--------
    rs1150974131,2
    C,F--66201054(+) TTCAGA/CAAAGT 2 -- int11Minor allele frequency- C:0.05WA 118
    rs76998581,2
    C,F,A--66201114(+) TTTATC/GAGTTT 2 -- int16Minor allele frequency- G:0.33NA CSA WA EA 363
    rs1425035221,2
    --66201179(+) AAGAGC/TAAAAG 2 -- int10--------
    rs1155180151,2
    C,F--66201204(+) TCAATG/ATTTCT 2 -- int11Minor allele frequency- A:0.02NA 120
    rs23497221,2
    C,F,A--66201229(+) AAAATG/ATATTC 2 -- int14Minor allele frequency- A:0.05NA WA 126
    rs1930858801,2
    --66201290(+) TCAGTA/GCTTAA 2 -- int10--------
    rs1154160141,2
    C,F--66201329(+) ATTCCT/CCCTCC 2 -- int11Minor allele frequency- C:0.10NA 120
    rs1167725161,2
    F--66201333(+) CTCCTC/TCTCAC 2 -- int11Minor allele frequency- T:0.11NA 120
    rs1149852121,2
    C,F--66201334(+) TCCTCC/TTCACC 2 -- int11Minor allele frequency- T:0.11NA 120
    rs1853465921,2
    --66201356(+) ATGCAA/TGAAAA 2 -- int10--------
    rs107132551,2
    C,F--66201375(+) TTTAAT/-TTTTT 2 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs21227211,2
    C,F,O,A,H--66201397(-) AGCCAC/TATTCA 2 -- int114Minor allele frequency- T:0.07NS EA NA WA 804
    rs747068311,2
    F--66201558(+) TTAATG/ATCTAT 2 -- int11Minor allele frequency- A:0.05WA 118
    rs1505342861,2
    --66201583(+) ATTGAA/TAAAAT 2 -- int10--------
    rs37527741,2
    C,F,H--66201634(-) AGATCC/TGAGTG 2 -- int113Minor allele frequency- T:0.04EA NS NA EU 4237
    rs1902467761,2
    C--66201636(+) CTCGGA/GTCTGG 2 -- int10--------
    rs1811485521,2
    C--66201657(+) GCAGGA/TTGCAT 4 T S mis10--------
    rs2004625321,2
    C--66201684(+) ACTACG/TTGGGT 4 S R mis10--------
    rs2000453291,2
    --66201703(+) AGCTTA/GTCCAA 4 D syn10--------
    rs1413468571,2
    F--66201811(+) CTTGGC/TAGACG 4 L syn11Minor allele frequency- T:0.00NA 4550
    rs1394953891,2
    C--66201829(+) TCCTCT/CACCGC 4 /V syn11Minor allele frequency- C:0.00NA 4550
    rs37527731,2
    C,H--66201832(-) AAAGCG/AGTAGA 4 /A syn15Minor allele frequency- A:0.01EA NS 1906
    rs1842645951,2
    C--66201847(+) ACCTGG/TATAAA 2 -- int10--------
    rs1445345061,2
    C--66201892(+) TAGTAC/TAGAAT 2 -- int10--------
    rs1882125721,2
    --66201986(+) ATCCAC/TGGCTA 2 -- int10--------
    rs131118111,2
    H--66202011(+) AAAATA/CCAACA 2 -- int14Minor allele frequency- C:0.00NS EA 408
    rs1810034801,2
    C--66202105(+) AAAATC/TTTGGT 2 -- int10--------
    rs1873566641,2
    --66202149(+) TATACA/TGTTCA 2 -- int10--------
    rs738221071,2
    C,F--66202171(+) TCCTTG/ACACTC 2 -- int12Minor allele frequency- A:0.09WA 120
    rs1921257381,2
    --66202306(+) CTTTTC/TGATGG 2 -- int10--------
    rs170860921,2
    C,F,H--66202345(+) TAGCAT/CAACTG 2 -- int114Minor allele frequency- C:0.23NA NS EA WA CSA 924
    rs1397838021,2
    --66202350(+) TAACTA/GTCTCA 2 -- int10--------
    rs1452882611,2
    --66202458(+) ATATCC/TTTGAT 2 -- int10--------
    rs170860961,2
    C,F,H--66202506(+) GTGAGG/ATCATT 2 -- int18Minor allele frequency- A:0.04NA NS EA WA 678
    rs350248651,2
    C--66202696(+) TTTAA-/CAATTA 2 -- int12Minor allele frequency- C:0.25NA 4
    rs1476751431,2
    --66202711(+) TAATTA/GTACTT 2 -- int10--------
    rs10205261,2
    C,F,A,H--66202712(-) AAAGTA/GTAATT 2 -- int19Minor allele frequency- G:0.50NA WA CSA EA 372
    rs787754041,2
    C,F--66202772(+) TAGGAA/GATTTA 2 -- int13Minor allele frequency- G:0.12CSA NA 124
    rs1824122311,2
    --66202781(+) TACAAA/TGATAA 2 -- int10--------
    rs1865836681,2
    --66202827(+) TAATTG/TTACAT 2 -- int10--------
    rs1407112421,