EPHA5 Gene

Aliases
for EPHA5 gene

Previous GC identifers: GC04U990011 GC04M066173 GC04M066014 GC04M065872 GC04M062095

Summaries
for EPHA5 gene

Genomic Views
for EPHA5 gene

RefSeq DNA sequence:

NC_000004.11  NC_018915.1  NT_022778.16  

SwitchGear Promoter luciferase reporter plasmid: EPHA5 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPHA5

EPHA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M066193:  view genomic region     (about GC identifiers)

Proteins
for EPHA5 gene

1 PDB 3D structure from and Proteopedia for EPHA5:

2R2P (3D)    

Explore the universe of human proteins at neXtProt for EPHA5: NX_P54756

Post-translational modifications:

	EMD Millipore Purified and/or Recombinant EPHA5 Protein
	R&D Systems Recombinant & Natural Proteins for EPHA5
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: EPHA5 OriGene Custom Protein Services for EPHA5
	GenScript Custom Purified and Recombinant Proteins Services for EPHA5
	Novus Biologicals EPHA5 Proteins
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for EPHA5

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for EPHA5
	Cell Signaling Technology (CST) Antibodies for EPHA5
	Browse OriGene Antibodies OriGene Custom Antibody Services for EPHA5
	GenScript Custom Superior Antibodies Services for EPHA5
	Novus Biologicals EPHA5 Antibodies
	Search for Antibodies for EPHA5 at Abcam
	Uscn Antibodies for EPHA5
	ThermoFisher Antibodies for EPHA5

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for EPHA5         (see all)
	GenScript EPHA5-Activity-based Kinase Assay for Compound Screening
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for EPHA5

Protein Domains /
Families
for EPHA5 gene

ProtoNet protein and cluster: P54756

Function
for EPHA5 gene

Enzyme Numbers (IUBMB): EC 2.7.10.1^{1 2} EC 2.7.10²

miRNA Products:		OriGene 3'-UTR Clone (see all 2): EPHA5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat EPHA5
		8/99 QIAGEN miScript miRNA Assays for microRNAs that regulate EPHA5 (see all 99):
		hsa-miR-323-3p hsa-miR-520e hsa-miR-4272 hsa-miR-106a hsa-miR-200a hsa-miR-605 hsa-miR-938 hsa-miR-519a
		SwitchGear 3'UTR luciferase reporter plasmid: EPHA5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for EPHA5 (see all 3) OriGene shRNA RFP: EPHA5 OriGene siRNA: EPHA5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat EPHA5

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for EPHA5

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for EPHA5 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for EPHA5 (see all 5) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): EPHA5 (NM_004439)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHA5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHA5

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for EPHA5
		LifeMap BioReagents: cell line associated with EPHA5: PureStem E15, Meso-prx/latp Progenitor

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA5

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Epha5)

Pathways & Interactions
for EPHA5 gene

	Super-pathway	contained gene-specific pathways
1	GPCR Pathway	GPCR Pathway 1.00 Estrogen Pathway 0.55 Ras Pathway 0.62 Pancreatic Adenocarcinoma 0.55 Breast Cancer Regulation by Stathmin1 0.58 Paxillin Interactions 0.53 NFAT in Immune Response 0.58 P2Y Receptor Signaling 0.38
2	Rho Family GTPases	Rho Family GTPases 1.00 MAPK Signaling 0.51 ERK Signaling 0.61 ILK Signaling 0.45 Molecular Mechanisms of Cancer 0.51
3	Nanog in Mammalian ESC Pluripotency	Nanog in Mammalian ESC Pluripotency 1.00 14-3-3 Induced Intracellular Signaling 0.59 GSK3 Signaling 0.61 eNOS Signaling 0.48
4	Actin Nucleation by ARP-WASP Complex	Actin Nucleation by ARP-WASP Complex 1.00 CDC42 Pathway 0.34 Actin Nucleation and Branching 0.66
5	G-protein signaling_RhoA regulation pathway	G-protein signaling_RhoA regulation pathway 1.00 EphrinA-EphR Signaling 0.26 G-protein signaling RhoA regulation pathway 1.00

3 EMD Millipore Pathways for EPHA5

	Neurophysiological process Receptor-mediated axon growth repulsion
	Cell adhesion Ephrins signaling
	G-protein signaling RhoA regulation pathway

5/32 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EPHA5

	Paxillin Interactions
	Molecular Mechanisms of Cancer
	Intracellular Calcium Signaling
	JNK Pathway
	P2Y Receptor Signaling

1 Cell Signaling Technology (CST) Pathway for EPHA5

Tyrosine Kinases / Adaptors

3 GeneGo (Thomson Reuters) Pathways for EPHA5

	Neurophysiological process Receptor-mediated axon growth repulsion
	G-protein signaling RhoA regulation pathway
	Cell adhesion Ephrins signaling

3 BioSystems Pathways for EPHA5

	EPHA forward signaling
	Ephrin A reverse signaling
	EphrinA-EPHA pathway

1         Kegg Pathway  (Kegg details for EPHA5)

Axon guidance

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

Drugs & Compounds
for EPHA5 gene

Transcripts
for EPHA5 gene

Expression
for EPHA5 gene

EPHA5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

5 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	PancreasIslets of LangerhansMature Beta Cells			Pancreas
	OvaryAntral FollicleCumulus Cells			Ovary
	BrainThalamus			Brain
	Neural TubeDiencephalon			Neural Tube
	Neural TubeTelencephalon			Neural Tube
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 6 LifeMap Cells
	Name			Category
	PureStem™ progenitor T42 (Embryonic Progenitor Cell)
	PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)			Adipose, Bone, Cartilage
	PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)			Adipose, Bone, Cartilage
	PureStem™ progenitor E69 (Embryonic Progenitor Cell)
	PureStem™ progenitor T36 (Embryonic Progenitor Cell)
	PureStem™ progenitor U31 (Embryonic Progenitor Cell)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for EPHA5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat EPHA5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat EPHA5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat EPHA5

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA5

Orthologs
for EPHA5 gene

Paralogs
for EPHA5 gene

Paralogs for EPHA5 gene

EPHB1²  EPHA2²  EPHB3²  EPHA4²  EPHB6²  EPHA6²  EPHB2²  EPHA1²  

EPHA8²  EPHA3²  EPHA7²  EPHB4²  EPHA10²  

18/49 SIMAP similar genes for EPHA5 using alignment to 5 protein entries:     EPHA5_HUMAN (see all proteins) (see all similar genes):

EPHA3    EPHA4    EPHA6    EPHA7    EPHB1    EPHB2

ABL1    EPHA8    EPHB2 variant protein    EPHA2    EPHB3    FGR

FES    tec    EPHA10    SRC    FYN    MET

EPHA5 for paralogs           About GeneDecksing

Genomic Variants
for EPHA5 gene

Disorders / Diseases
for EPHA5 gene

Publications
for EPHA5 gene

PubMed articles for EPHA5 gene integrated from 9 sources (see top 10): (articles sorted by number of sources associating them with EPHA5)

Utopia: connect your pdf to the dynamic world of online information

1. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PubMed id 9267020)^{1, 2, 3} (1997)
2. Immunohistochemical localization of EphA5 in the adul t human central nervous system. (PubMed id 10375373)^{1, 2} Olivieri G. and Miescher G.C. (1999)
3. Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial tumors. (PubMed id 9191074)^{1, 2} Miescher G.C....Steck A.J. (1997)
4. cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. (PubMed id 7898931)^{1, 2} Fox G.M.... Welcher A.A. (1995)
5. A YAC contig spanning a cluster of human type III rec eptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12 . (PubMed id 7528718)^{1, 3} Spritz R.A....Moir D.T. (1994)
6. Frequent epigenetic inactivation of the receptor tyro sine kinase EphA5 by promoter methylation in human breast cancer. (PubMed id 19733895)^{1, 9} Fu D.Y....Shao Z.M. (2010)
7. Functional activation of EphA5 receptor does not promote cell proliferation in the aberrant EphA5 expressing human glioblastoma U-118 MG cell line. (PubMed id 10064801)^{1, 9} Bruce V....Miescher G.C. (1999)
8. Regulation of topographic projection by the Eph family receptor Bsk (EphA5) and its ligands. (PubMed id 9321686)^{1, 9} Zhou R. (1997)
9. MicroRNA-34a regulates migration of chondroblast and IL-1I^-induced degeneration of chondrocytes by targeting EphA5. (PubMed id 22079638)¹ Kim D....Jin E.J. (2011)
10. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PubMed id 22174851)¹ Lingappa J.R....Goldstein D. (2011)
11. Development and validation of a method for profiling post-translational modification activities using protein microarrays. (PubMed id 20596523)¹ Del RincA^n S.V....Spruck C. (2010)
12. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
13. Clinical significance of ephrin (eph)-A1, -A2, -a4, - a5 and -a7 receptors in pancreatic ductal adenocarcinoma. (PubMed id 19949912)¹ Giaginis C....Theocharis S.E. (2010)
14. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)¹ Persaud A....Rotin D. (2009)
15. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)² Greenman C.... Stratton M.R. (2007)
16. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
17. Over-expression of Eph and ephrin genes in advanced ovarian cancer: ephrin gene expression correlates with shortened survival. (PubMed id 16737551)¹ Herath N.I....Boyd A.W. (2006)
18. The LIFEdb database in 2006. (PubMed id 16381901)¹ Mehrle A....Wiemann S. (2006)
19. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
20. Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells. (PubMed id 15485908)¹ Yuan Z.L....Chin Y.E. (2004)
21. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)¹ Wiemann S....Poustka A. (2004)
22. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
23. Multiple roles of EPH receptors and ephrins in neural development. (PubMed id 11256076)¹ Wilkinson D.G. (2001)
24. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)¹ Wiemann S.... Poustka A. (2001)
25. A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes. (PubMed id 10607706)¹ Aasheim H.-C....Logtenberg T. (2000)
26. Eph receptors and ephrins: regulators of guidance and assembly. (PubMed id 10730216)¹ Wilkinson D.G. (2000)
27. Roles of Eph receptors and ephrins in segmental patterning. (PubMed id 11128993)¹ Xu Q....Wilkinson D.G. (2000)
28. DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)¹ Hartley J.L....Brasch M.A. (2000)
29. Regulation of learning by EphA receptors: a protein targeting study. (PubMed id 10531456)¹ Gerlai R....Phillips H.S. (1999)
30. A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting. (PubMed id 10516308)¹ Stein E....Skutella T. (1999)
31. Eph receptors and ephrins: effectors of morphogenesis. (PubMed id 10207129)¹ Holder N. and Klein R. (1999)
32. The Eph family receptors and ligands. (PubMed id 9576626)¹ Zhou R. (1998)
33. The ephrins and Eph receptors in neural development. (PubMed id 9530499)¹ Flanagan J.G. and Vanderhaeghen P. (1998)
34. A link between axon guidance and axon fasciculation suggested by studies of the tyrosine kinase receptor EphA5/REK7 and its ligand ephrin-A5/AL-1. (PubMed id 9321687)¹ Caras I.W. (1997)
35. Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. (PubMed id 8755474)¹ Gale N.W....Yancopoulos G.D. (1996)
36. Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation. (PubMed id 7748564)² Winslow J.W.... Caras I.W. (1995)
37. Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. (PubMed id 7973638)¹ Davis S.... Yancopoulos G.D. (1994)
38. Identification of a complete Cek7 receptor protein tyrosine kinase coding sequence and cDNAs of alternatively spliced transcripts. (PubMed id 7958948)⁹ Siever D.A. and Verderame M.F. (1994)
39. Transcriptional switch of dormant tumors to fast-growing angiogenic phenotype. (PubMed id 19176381)⁹ Almog N....Abdollahi A. (2009)
40. Disruption of ephrin signaling associates with disordered axophilic migration of the gonadotropin-releasing hormone neurons. (PubMed id 15788771)⁹ Gamble J.A....Herbison A.E. (2005)
41. Molecular evidence for the early specification of presumptive functional domains in the embryonic primate cerebral cortex. (PubMed id 10407035)⁹ Donoghue M.J. and Rakic P. (1999)
42. Gene expression profiling of human mesenchymal stem cells for identification of novel markers in early- and late-stage cell culture. (PubMed id 18550633)⁹ Tanabe S....Yamaguchi T. (2008)
43. Comparative integromics on Eph family. (PubMed id 16596241)⁹ Katoh M. and Katoh M. (2006)
44. Regional differences in the developing cerebral cortex revealed by ephrin-A5 expression. (PubMed id 10498278)⁹ Mackarehtschian K....McConnell S.K. (1999)

External Searches for EPHA5 gene

Genome Databases showing EPHA5 gene

Other Databases showing EPHA5 gene

Specialized Databases showing EPHA5 gene

Products
for EPHA5 gene