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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

EPHA5 Gene

protein-coding   GIFtS: 66
GCID: GC04M066193

EPH Receptor A5

(Previous name: EphA5)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
EPH Receptor A51 2     EC 2.7.10.13 8
HEK72 3 5     EphA51
TYRO42 3 5     CEK72
Brain-Specific Kinase2 3     Ephrin Type-A Receptor 52
EHK-12 3     Receptor Protein-Tyrosine Kinase HEK72
EHK12 3     Tyrosine-Protein Kinase Receptor EHK-12
EK72 3     BSK3
EPH Homology Kinase 12 3     hEK73
EPH-Like Kinase 72 3     EC 2.7.108

External Ids:    HGNC: 33891   Entrez Gene: 20442   Ensembl: ENSG000001452427   OMIM: 6000045   UniProtKB: P547563   

Export aliases for EPHA5 gene to outside databases

Previous GC identifers: GC04U990011 GC04M066173 GC04M066014 GC04M065872 GC04M062095


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for EPHA5 Gene:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related
receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors
in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich
domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity
of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
Alternatively spliced transcript variants encoding different isoforms have been described. (provided by RefSeq,
Aug 2013)

GeneCards Summary for EPHA5 Gene: 
EPHA5 (EPH receptor A5) is a protein-coding gene. Diseases associated with EPHA5 include drug psychosis, and pancreatic ductal adenocarcinoma, and among its related super-pathways are Ras Pathway and MAPK Signaling. GO annotations related to this gene include GPI-linked ephrin receptor activity and transmembrane-ephrin receptor activity. An important paralog of this gene is EPHB1.

UniProtKB/Swiss-Prot: EPHA5_HUMAN, P54756
Function: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on
adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably
constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development
and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways.
Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis.
Beside its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between
pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity)

Gene Wiki entry for EPHA5 (EPH receptor A5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_022778.16  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the EPHA5 gene promoter:
         C/EBPbeta   p53   Pbx1a   ATF-2   Nkx2-2   CRE-BP1   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidEPHA5 promoter sequence
   Search SABiosciences Chromatin IP Primers for EPHA5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPHA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.1   Ensembl cytogenetic band:  4q13.1   HGNC cytogenetic band: 4q13.1

EPHA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHA5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M066193:  view genomic region     (about GC identifiers)

Start:
66,185,281 bp from pter      End:
66,536,213 bp from pter
Size:
350,933 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EPHA5_HUMAN, P54756 (See protein sequence)
Recommended Name: Ephrin type-A receptor 5 precursor  
Size: 1037 amino acids; 114803 Da
Subunit: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a
receptor dimer. Oligomerization is probably required to induce biological responses (By similarity)
Subcellular location: Cell membrane (By similarity); Single-pass type I membrane protein (By similarity). Cell
projection, axon (By similarity). Cell projection, dendrite
2 PDB 3D structures from and Proteopedia for EPHA5:
2R2P (3D)        4ET7 (3D)    
Secondary accessions: Q7Z3F2
Alternative splicing: 3 isoforms:  P54756-1   P54756-2   P54756-3   

Explore the universe of human proteins at neXtProt for EPHA5: NX_P54756

Explore proteomics data for EPHA5 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Phosphorylation is stimulated by the ligand EFNA5. Dephosphorylation upon stimulation by glucose,
    inhibits EPHA5 forward signaling and results in insulin secretion (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P54756

  • 4/49 DME Specific Peptides for EPHA5 (P54756) (see all 49)
     RDLAARN  DTGGRKD  YVFQIRA  EEGYRLP 

    EPHA5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    EPHA5 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001268694.1  NP_001268695.1  NP_001268696.1  NP_004430.4  NP_872272.2  

    ENSEMBL proteins: 
     ENSP00000273854   ENSP00000389208   ENSP00000346899   ENSP00000427638  

    Human Recombinant Protein Products for EPHA5: 
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    Novus Biologicals EPHA5 Proteins
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EPHA5 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005791rough endoplasmic reticulum IDA10375373
    GO:0005886plasma membrane IDA10375373
    GO:0005887integral to plasma membrane IEA--
    GO:0009897external side of plasma membrane IDA10064801
    GO:0016021integral to membrane ----

    EPHA5 for ontologies           About GeneDecksing



    EPHA5 Antibody Products: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EPHA5 
    Cloud-Clone Corp. CLIAs for EPHA5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FN3: Fibronectin type III domain containing
    EPH: EPH receptors
    SAMD: Sterile alpha motif (SAM) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: EPH receptor A5 
    Ephrin receptor family
    Ephrin receptor family

    5/15 InterPro protein domains (see all 15):
     IPR017441 Protein_kinase_ATP_BS
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR003961 Fibronectin_type3

    Graphical View of Domain Structure for InterPro Entry P54756

    ProtoNet protein and cluster: P54756

    5 Blocks protein domains:
    IPB001090 Ephrin receptor
    IPB001426 Receptor tyrosine kinase
    IPB001660 Sterile alpha motif SAM
    IPB003962 Fibronectin type III repeat signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EPHA5_HUMAN, P54756
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    EPHA5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EPHA5_HUMAN, P54756
    Function: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on
    adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
    pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
    the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably
    constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development
    and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways.
    Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis.
    Beside its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between
    pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity)
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0005003ephrin receptor activity ISS--
    GO:0005004GPI-linked ephrin receptor activity ISS--
    GO:0005005transmembrane-ephrin receptor activity NAS7898931
         
    EPHA5 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Epha5):
     nervous system 

    EPHA5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for EPHA5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for EPHA5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for EPHA5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for EPHA5 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidEPHA5 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for EPHA5 About   (see all 21)                                                                                              See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    2Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    CDC42 Pathway0.41
    Actin Nucleation and Branching0.66
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for EPHA5
        Neurophysiological process Receptor-mediated axon growth repulsion
    Cell adhesion Ephrins signaling
    G-protein signaling RhoA regulation pathway

    5/32 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for EPHA5 (see all 32)
        Paxillin Interactions
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    JNK Pathway
    P2Y Receptor Signaling

    1 Cell Signaling Technology (CST) Pathway for EPHA5
        Tyrosine Kinases / Adaptors

    3 GeneGo (Thomson Reuters) Pathways for EPHA5
        Neurophysiological process Receptor-mediated axon growth repulsion
    G-protein signaling RhoA regulation pathway
    Cell adhesion Ephrins signaling

    3 BioSystems Pathways for EPHA5
        EPHA forward signaling
    Ephrin A reverse signaling
    EphrinA-EPHA pathway


    1         Kegg Pathway  (Kegg details for EPHA5):
        Axon guidance


    EPHA5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for EPHA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/25 Interacting proteins for EPHA5 (P547563 ENSP000002738544) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EFNA2O439213, ENSP000002153684I2D: score=2 STRING: ENSP00000215368
    EFNA5P528033, ENSP000003287774I2D: score=2 STRING: ENSP00000328777
    EFNA1P208273, ENSP000003573924I2D: score=1 STRING: ENSP00000357392
    EFNA3P527973, ENSP000003573934I2D: score=1 STRING: ENSP00000357393
    STAT3P407633, ENSP000002646574I2D: score=1 STRING: ENSP00000264657
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway ----
    GO:0007411axon guidance ISS--
    GO:0019933cAMP-mediated signaling ISS--
    GO:0021766hippocampus development ISS--

    EPHA5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    EPHA5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for EPHA5

    2 HMDB Compounds for EPHA5    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 Novoseek inferred chemical compound relationship for EPHA5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 31.9 2 10064801 (1), 19733895 (1)

    Search CenterWatch for drugs/clinical trials and news about EPHA5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for EPHA5 gene (5 alternative transcripts): 
    NM_001281765.1  NM_001281766.1  NM_001281767.1  NM_004439.6  NM_182472.3  

    Unigene Cluster for EPHA5:

    EPH receptor A5
    Hs.654492  [show with all ESTs]
    Unigene Representative Sequence: NM_004439
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273854(uc003hcx.3 uc003hcy.3 uc003hcz.3 uc011cah.2 uc011cai.2)
    ENST00000432638 ENST00000354839 ENST00000511294(uc003hda.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB209375.1 AK307826.1 BC136257.1 BC136258.1 BC143427.1 BX537946.1 L36644.1 

    4 DOTS entries:

    DT.65287326  DT.95152379  DT.407663  DT.95153288 

    24/27 AceView cDNA sequences (see all 27):

    BX642416 BX102577 BM693322 BE219686 H11658 AV718336 AI697835 BX477839 
    D81888 BX505546 BF433558 BM664168 AI867137 BE218107 D82015 AA121200 
    T07343 T06040 AI694040 NM_004439 AW341789 H12187 BG925074 BX537946 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    EPHA5 expression in normal human tissues (normalized intensities)      EPHA5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    EPHA5 Expression
    About this image


    EPHA5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             superior temporal gyrus   
     
     Uncategorized (Uncategorized)    fully expand to see all 4 entries
             PureStem Progenitor E72
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             Immature Schwann Cells Peripheral Nerve Domain
             spinal/ganglion/dorsal root ganglion   
     
     Ectoderm (Gastrulation Derivatives)
             PureStem ES-210, Ecto-ntu Progenitor
     
     Blood (Hematopoietic System)
             Umbilical cord blood-derived mesenchymal stem cells

    See EPHA5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for EPHA5

    SOURCE GeneReport for Unigene cluster: Hs.654492

    UniProtKB/Swiss-Prot: EPHA5_HUMAN, P54756
    Tissue specificity: Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje
    cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from
    the forebrain to hindbrain and spinal cord

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for EPHA5 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Epha51 , 5 Eph receptor A51, 5 90.35(n)1
    96.12(a)1
      5 (43.00 cM)5
    138391  NM_007937.31  NP_031963.21 
     840577915 
    chicken
    (Gallus gallus)
    Aves EPHA51 EPH receptor A5 83.93(n)
    93.53(a)
      395997  NM_205105.2  NP_990436.2 
    lizard
    (Anolis carolinensis)
    Reptilia EPHA56
    Uncharacterized protein
    93(a)
    1 ↔ 1
    GL343345.1(579409-856437)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7975951 ephrin type-A receptor 5-like 72.55(n)
    79.67(a)
      797595  XM_001338028.4  XP_001338064.4 


    ENSEMBL Gene Tree for EPHA5 (if available)
    TreeFam Gene Tree for EPHA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for EPHA5 gene
    EPHB12  EPHA22  EPHB32  EPHA42  EPHB62  EPHA62  EPHA12  EPHB22  
    EPHA82  EPHA32  EPHA72  EPHA102  EPHB42  
    18/47 SIMAP similar genes for EPHA5 using alignment to 5 protein entries:     EPHA5_HUMAN (see all proteins) (see all similar genes):
    EPHA3    EPHA4    EPHA6    EPHA7    EPHB1    EPHB2
    ABL1    EPHA8    EPHB2 variant protein    EPHA2    EPHB3    FGR
    FES    tec    EPHA10    FYN    SRC    MET

    EPHA5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7811 SNPs in EPHA5 are shown (see all 7811)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0421434
    A lung adenocarcinoma sample4--see VAR_0421432 G E mis40--------
    VAR_0421484
    A lung large cell carcinoma sample4--see VAR_0421482 N S mis40--------
    VAR_0421424
    A lung large cell carcinoma sample4--see VAR_0421422 E K mis40--------
    VAR_0421414
    A lung adenocarcinoma sample4--see VAR_0421412 R Q mis40--------
    VAR_0421464
    A lung squamous cell carcinoma sample4--see VAR_0421462 T I mis40--------
    rs58589651,2
    C--62308692(+) TACAG-/T/TT  
            
    TTTTT
    2 -- int10--------
    rs712054021,2
    C--62432188(+) AAAAA-/A/AAA 
            
    GTCCC
    2 -- int11NA 2
    rs58589801,2
    C--62435386(+) aaaaa-/AAAAAA/AAAAAAAA
    AA
    /AAAAAAAAAAAAAAA
    CAGGA
    6 -- int1 cds11NA 2
    rs1811157901,2
    --66184833(+) GACACA/GATACT 2 -- ds50010--------
    rs726402351,2
    --66184947(+) TTGGGC/TTGATG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for EPHA5 (66185281 - 66435281 bp, first 250kb of EPHA5)

    Structural Variations
         Database of Genomic Variants (DGV) 10/32 variations for EPHA5 (see all 32):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2671686CNV Deletion23128226
    esv2727749CNV Deletion23290073
    esv2727748CNV Deletion23290073
    esv2727747CNV Deletion23290073
    esv2294940CNV Deletion18987734
    esv2501169CNV Deletion19546169
    esv2676800CNV Deletion23128226
    esv2021289CNV Deletion18987734
    esv2422517CNV Duplication17116639
    nsv291266CNV Insertion16902084


    Human Gene Mutation Database (HGMD): EPHA5
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600004    OMIM disorders: --

    9 diseases for EPHA5:    About MalaCards
    drug psychosis    pancreatic ductal adenocarcinoma    glioblastoma    cerebritis
    adenocarcinoma    ovarian cancer    pancreatitis    breast cancer
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for EPHA5:
    Drug psychosis

    EPHA5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): EPHA5
    Human Genome Epidemiology (HuGE) Navigator: EPHA5 (1 document)

    Export disorders for EPHA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for EPHA5 gene integrated from 9 sources (see top 10):
    (articles sorted by number of sources associating them with EPHA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PubMed id 9267020)1, 2, 3 (1997)
    2. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PubMed id 22174851)1, 4 Lingappa J.R....Goldstein D. (2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Immunohistochemical localization of EphA5 in the adul t human central nervous system. (PubMed id 10375373)1, 2 Olivieri G. and Miescher G.C. (1999)
    5. Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial tumors. (PubMed id 9191074)1, 2 Miescher G.C....Steck A.J. (1997)
    6. cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. (PubMed id 7898931)1, 2 Fox G.M.... Welcher A.A. (1995)
    7. A YAC contig spanning a cluster of human type III rec eptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12 . (PubMed id 7528718)1, 3 Spritz R.A....Moir D.T. (1994)
    8. Frequent epigenetic inactivation of the receptor tyro sine kinase EphA5 by promoter methylation in human breast cancer. (PubMed id 19733895)1, 9 Fu D.Y....Shao Z.M. (2010)
    9. Functional activation of EphA5 receptor does not promote cell proliferation in the aberrant EphA5 expressing human glioblastoma U-118 MG cell line. (PubMed id 10064801)1, 9 Bruce V....Miescher G.C. (1999)
    10. Regulation of topographic projection by the Eph family receptor Bsk (EphA5) and its ligands. (PubMed id 9321686)1, 9 Zhou R. (1997)
    11. MicroRNA-34a regulates migration of chondroblast and IL-1I^-induced degeneration of chondrocytes by targeting EphA5. (PubMed id 22079638)1 Kim D....Jin E.J. (2011)
    12. Development and validation of a method for profiling post-translational modification activities using protein microarrays. (PubMed id 20596523)1 Del RincA^n S.V....Spruck C. (2010)
    13. Clinical significance of ephrin (eph)-A1, -A2, -a4, - a5 and -a7 receptors in pancreatic ductal adenocarcinoma. (PubMed id 19949912)1 Giaginis C....Theocharis S.E. (2010)
    14. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
    15. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
    16. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (2007)
    17. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    18. Over-expression of Eph and ephrin genes in advanced ovarian cancer: ephrin gene expression correlates with shortened survival. (PubMed id 16737551)1 Herath N.I....Boyd A.W. (2006)
    19. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    20. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    21. Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells. (PubMed id 15485908)1 Yuan Z.L....Chin Y.E. (2004)
    22. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
    23. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    24. Multiple roles of EPH receptors and ephrins in neural development. (PubMed id 11256076)1 Wilkinson D.G. (2001)
    25. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1 Wiemann S.... Poustka A. (2001)
    26. A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes. (PubMed id 10607706)1 Aasheim H.-C....Logtenberg T. (2000)
    27. Eph receptors and ephrins: regulators of guidance and assembly. (PubMed id 10730216)1 Wilkinson D.G. (2000)
    28. Roles of Eph receptors and ephrins in segmental patterning. (PubMed id 11128993)1 Xu Q....Wilkinson D.G. (2000)
    29. DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)1 Hartley J.L....Brasch M.A. (2000)
    30. Regulation of learning by EphA receptors: a protein targeting study. (PubMed id 10531456)1 Gerlai R....Phillips H.S. (1999)
    31. A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting. (PubMed id 10516308)1 Stein E....Skutella T. (1999)
    32. Eph receptors and ephrins: effectors of morphogenesis. (PubMed id 10207129)1 Holder N. and Klein R. (1999)
    33. The Eph family receptors and ligands. (PubMed id 9576626)1 Zhou R. (1998)
    34. The ephrins and Eph receptors in neural development. (PubMed id 9530499)1 Flanagan J.G. and Vanderhaeghen P. (1998)
    35. A link between axon guidance and axon fasciculation suggested by studies of the tyrosine kinase receptor EphA5/REK7 and its ligand ephrin-A5/AL-1. (PubMed id 9321687)1 Caras I.W. (1997)
    36. Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. (PubMed id 8755474)1 Gale N.W....Yancopoulos G.D. (1996)
    37. Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation. (PubMed id 7748564)2 Winslow J.W.... Caras I.W. (1995)
    38. Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. (PubMed id 7973638)1 Davis S.... Yancopoulos G.D. (1994)
    39. Identification of a complete Cek7 receptor protein tyrosine kinase coding sequence and cDNAs of alternatively spliced transcripts. (PubMed id 7958948)9 Siever D.A. and Verderame M.F. (1994)
    40. Transcriptional switch of dormant tumors to fast-growing angiogenic phenotype. (PubMed id 19176381)9 Almog N....Abdollahi A. (2009)
    41. Disruption of ephrin signaling associates with disordered axophilic migration of the gonadotropin-releasing hormone neurons. (PubMed id 15788771)9 Gamble J.A....Herbison A.E. (2005)
    42. Molecular evidence for the early specification of presumptive functional domains in the embryonic primate cerebral cortex. (PubMed id 10407035)9 Donoghue M.J. and Rakic P. (1999)
    43. Gene expression profiling of human mesenchymal stem cells for identification of novel markers in early- and late-stage cell culture. (PubMed id 18550633)9 Tanabe S....Yamaguchi T. (2008)
    44. Comparative integromics on Eph family. (PubMed id 16596241)9 Katoh M. and Katoh M. (2006)
    45. Regional differences in the developing cerebral cortex revealed by ephrin-A5 expression. (PubMed id 10498278)9 Mackarehtschian K....McConnell S.K. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2044 HGNC: 3389 AceView: EPHA5 Ensembl:ENSG00000145242 euGenes: HUgn2044
    ECgene: EPHA5 Kegg: 2044 H-InvDB: EPHA5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for EPHA5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EPHA5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for EPHA5 gene:
    Search GeneIP for patents involving EPHA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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