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EPHA5 Gene

protein-coding   GIFtS: 67
GCID: GC04M066193

EPH Receptor A5

(Previous name: EphA5)
  See EPHA5-related disease
at
MalaCards
 

Aliases
for EPHA5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
EPH Receptor A51 2     EC 2.7.10.13 8
HEK72 3 5     EphA51
TYRO42 3 5     CEK72
Brain-Specific Kinase2 3     Ephrin Type-A Receptor 52
EHK-12 3     Receptor Protein-Tyrosine Kinase HEK72
EHK12 3     Tyrosine-Protein Kinase Receptor EHK-12
EK72 3     BSK3
EPH Homology Kinase 12 3     hEK73
EPH-Like Kinase 72 3     EC 2.7.108

External Ids:    HGNC: 33891   Entrez Gene: 20442   Ensembl: ENSG000001452427   OMIM: 6000045   UniProtKB: P547563   

Export aliases for EPHA5 gene to outside databases

Previous GC identifers: GC04U990011 GC04M066173 GC04M066014 GC04M065872 GC04M062095


Summaries
for EPHA5 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for EPHA5 Gene:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related
receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors
in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich
domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity
of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
Alternatively spliced transcript variants encoding different isoforms have been described. (provided by RefSeq,
Aug 2013)

GeneCards Summary for EPHA5 Gene:
EPHA5 (EPH receptor A5) is a protein-coding gene. Diseases associated with EPHA5 include drug psychosis. GO annotations related to this gene include GPI-linked ephrin receptor activity and transmembrane-ephrin receptor activity. An important paralog of this gene is EPHB1.

UniProtKB/Swiss-Prot: EPHA5_HUMAN, P54756
Function: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on
adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably
constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development
and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways.
Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis.
Beside its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between
pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity)

Gene Wiki entry for EPHA5 (EPH receptor A5) Gene


Genomic Views
for EPHA5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the EPHA5 gene promoter:
         C/EBPbeta   p53   Pbx1a   ATF-2   Nkx2-2   CRE-BP1   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: EPHA5 promoter sequence
   Search Chromatin IP Primers for EPHA5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat EPHA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.1   Ensembl cytogenetic band:  4q13.1   HGNC cytogenetic band: 4q13.1

EPHA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
EPHA5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M066193:  view genomic region     (about GC identifiers)

Start:
 66,185,281 bp from pter      End:
 66,536,213 bp from pter
Size:
 350,933 bases      Orientation:
 minus strand

Proteins
for EPHA5 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: EPHA5_HUMAN, P54756 (See protein sequence)
Recommended Name: Ephrin type-A receptor 5 precursor  
Size: 1037 amino acids; 114803 Da
Subunit: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a
receptor dimer. Oligomerization is probably required to induce biological responses (By similarity)
2 PDB 3D structures from and Proteopedia for EPHA5:
2R2P (3D)        4ET7 (3D)    
Secondary accessions: Q7Z3F2
Alternative splicing: 3 isoforms:  P54756-1   P54756-2   P54756-3   

Explore the universe of human proteins at neXtProt for EPHA5: NX_P54756

Explore proteomics data for EPHA5 at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation is stimulated by the ligand EFNA5. Dephosphorylation upon stimulation by glucose,
    inhibits EPHA5 forward signaling and results in insulin secretion (By similarity)1
  • Glycosylation2 at Asn264, Asn299, Asn369, Asn423, Asn436, Asn461
  • Modification sites at PhosphoSitePlus
    • Selected DME Specific Peptides for EPHA5 (P54756) (see all 49)
     RDLAARN  DTGGRKD  YVFQIRA  EEGYRLP 


    See EPHA5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001268694.1  NP_001268695.1  NP_001268696.1  NP_004430.4  NP_872272.2  

    ENSEMBL proteins: 
     ENSP00000273854   ENSP00000389208   ENSP00000346899   ENSP00000427638  

    EPHA5 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant EPHA5 Protein
    R&D Systems Recombinant & Natural Proteins for EPHA5
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for EPHA5
    OriGene Protein Over-expression Lysate for EPHA5
    OriGene Custom MassSpec
    OriGene Custom Protein Services for EPHA5
    GenScript Custom Purified and Recombinant Proteins Services for EPHA5
    Novus Biologicals EPHA5 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for EPHA5

         		 Search eBioscience for Proteins for EPHA5 

         		antibodies-online proteins for EPHA5 (5 products) 

         		antibodies-online peptides for EPHA5

    EPHA5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for EPHA5
    Cell Signaling Technology (CST) Antibodies for EPHA5 
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    OriGene Custom Antibody Services for EPHA5
    Novus Biologicals EPHA5 Antibodies
    Abcam antibodies for EPHA5
    Cloud-Clone Corp. Antibodies for EPHA5
    ThermoFisher Antibodies for EPHA5
    antibodies-online antibodies for EPHA5 (97 products) 

    EPHA5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for EPHA5
    R&D Systems ELISAs for EPHA5         (see all)
    GenScript EPHA5-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for EPHA5
    Cloud-Clone Corp. CLIAs for EPHA5
    Search eBioscience for ELISAs for EPHA5 
    antibodies-online kits for EPHA5 (9 products) 

    Domains /
    Families
    for EPHA5 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    EPH: EPH receptors
    SAMD: Sterile alpha motif (SAM) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: EPH receptor A5
    Ephrin receptor family
    Ephrin receptor family

    Selected InterPro protein domains (see all 16):
     IPR017441 Protein_kinase_ATP_BS
     IPR003961 Fibronectin_type3
     IPR021129 SAM_type1
     IPR011009 Kinase-like_dom
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P54756

    ProtoNet protein and cluster: P54756

    5 Blocks protein domains:
    IPB001090 Ephrin receptor
    IPB001426 Receptor tyrosine kinase
    IPB001660 Sterile alpha motif SAM
    IPB003962 Fibronectin type III repeat signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: EPHA5_HUMAN, P54756
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily
    Similarity: Contains 1 Eph LBD (Eph ligand-binding) domain
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Find genes that share domains with EPHA5           About GenesLikeMe


    Function
    for EPHA5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EPHA5_HUMAN, P54756
    Function: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on
    adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling
    pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of
    the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably
    constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development
    and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways.
    Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis.
    Beside its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between
    pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity)
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0005003ephrin receptor activity ISS--
    GO:0005004GPI-linked ephrin receptor activity ISS--
    GO:0005005transmembrane-ephrin receptor activity NAS7898931
         
    Find genes that share ontologies with EPHA5           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Epha5):
     nervous system 

    Find genes that share phenotypes with EPHA5           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for EPHA5

    miRNA
    Products:            		miRTarBase miRNAs that target EPHA5:
    hsa-mir-181a-5p (MIRT025144), hsa-mir-34a-5p (MIRT006576)

    Block miRNA regulation of human, mouse, rat EPHA5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EPHA5 (see all 99):
    hsa-miR-323-3p hsa-miR-520e hsa-miR-4272 hsa-miR-106a hsa-miR-200a hsa-miR-605 hsa-miR-938 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: EPHA5 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for EPHA5
    Predesigned siRNA for gene silencing in human, mouse, rat EPHA5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for EPHA5

    Clone
    Products:             		 OriGene clones in human, mouse for EPHA5 (see all 18)
    OriGene ORF clones in mouse, rat for EPHA5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): EPHA5 (NM_004439)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHA5
    Addgene plasmids for EPHA5 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for EPHA5
    ESI BIO PureStem Progenitor for EPHA5: 
    PureStem E15, Meso-prx/latp Progenitor
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA5


    Localization
    for EPHA5 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Subcellular locations from UniProtKB/Swiss-Prot
    EPHA5_HUMAN, P54756: Cell membrane (By similarity); Single-pass type I membrane protein (By similarity). Cell
    projection, axon (By similarity). Cell projection, dendrite
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    cytosol1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005791rough endoplasmic reticulum IDA10375373
    GO:0005886plasma membrane IDA10375373
    GO:0005887integral component of plasma membrane IEA--
    GO:0009897external side of plasma membrane IDA10064801
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with EPHA5           About GenesLikeMe


    Pathways & Interactions
    for EPHA5 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for EPHA5 About   (see all 19)  
    See pathways by source

    		      Powered
    by    		     
    SuperPathContained pathways About
    1GPCR Pathway
    		Ras Pathway0.73
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.73
    		NFAT in Immune Response0.58
    		GPCR Pathway0.62
    		Estrogen Pathway0.55
    		Pancreatic Adenocarcinoma0.59
    		P2Y Receptor Signaling0.38
    2ERK Signaling
    		ERK Signaling0.61
    		Molecular Mechanisms of Cancer0.51
    		Rho Family GTPases0.61
    		ILK Signaling0.49
    		MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency0.61
    		14-3-3 Induced Intracellular Signaling0.59
    		GSK3 Signaling0.61
    		eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    		Actin Nucleation by ARP-WASP Complex0.66
    		CDC42 Pathway0.41
    		Actin Nucleation and Branching0.66
    5EPHA forward signaling
    		EPHA forward signaling
    		Ephrin A reverse signaling0.00
    		EphrinA-EPHA pathway0.00


    Find genes that share SuperPaths with EPHA5           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for EPHA5 (see all 32)
        Paxillin Interactions
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    JNK Pathway
    P2Y Receptor Signaling

    1 Cell Signaling Technology (CST) Pathway for EPHA5
        Tyrosine Kinases / Adaptors

    3 GeneGo (Thomson Reuters) Pathways for EPHA5
        Neurophysiological process Receptor-mediated axon growth repulsion
    G-protein signaling RhoA regulation pathway
    Cell adhesion Ephrins signaling

    3 BioSystems Pathways for EPHA5
        EPHA forward signaling
    Ephrin A reverse signaling
    EphrinA-EPHA pathway


    1 Kegg Pathway  (Kegg details for EPHA5):
        Axon guidance

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for EPHA5
    Interactions:

        Search GeneGlobe Interaction Network for EPHA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for EPHA5 (P547563 ENSP000002738544) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EFNA2O439213, ENSP000002153684I2D: score=2 STRING: ENSP00000215368
    EFNA5P528033, ENSP000003287774I2D: score=2 STRING: ENSP00000328777
    EFNA1P208273, ENSP000003573924I2D: score=1 STRING: ENSP00000357392
    EFNA3P527973, ENSP000003573934I2D: score=1 STRING: ENSP00000357393
    STAT3P407633, ENSP000002646574I2D: score=1 STRING: ENSP00000264657
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway ----
    GO:0007411axon guidance ISS--
    GO:0019933cAMP-mediated signaling ISS--
    GO:0021766hippocampus development ISS--

    Find genes that share ontologies with EPHA5           About GenesLikeMe



    Drugs & Compounds
    for EPHA5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for EPHA5

    2 HMDB Compounds for EPHA5    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 Novoseek inferred chemical compound relationship for EPHA5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 31.9 2 10064801 (1), 19733895 (1)



    Find genes that share compounds with EPHA5           About GenesLikeMe



    Transcripts
    for EPHA5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for EPHA5 gene (5 alternative transcripts): 
    NM_001281765.1  NM_001281766.1  NM_001281767.1  NM_004439.6  NM_182472.3  

    Unigene Cluster for EPHA5:

    EPH receptor A5
    Hs.654492  [show with all ESTs]
    Unigene Representative Sequence: NM_004439
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273854(uc003hcx.3 uc003hcy.3 uc003hcz.3 uc011cah.2 uc011cai.2)
    ENST00000432638 ENST00000354839 ENST00000511294(uc003hda.2)
    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat EPHA5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate EPHA5 (see all 99):
    hsa-miR-323-3p hsa-miR-520e hsa-miR-4272 hsa-miR-106a hsa-miR-200a hsa-miR-605 hsa-miR-938 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: EPHA5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat EPHA5
    Clone
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    OriGene ORF clones in mouse, rat for EPHA5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): EPHA5 (NM_004439)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for EPHA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat EPHA5
    Addgene plasmids for EPHA5 
    Primer
    Products:            		OriGene qSTAR qPCR primer pairs in human, mouse for EPHA5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat EPHA5
      QuantiTect SYBR Green Assays in human, mouse, rat EPHA5
      QuantiFast Probe-based Assays in human, mouse, rat EPHA5

    Additional mRNA sequence: 

    AB209375.1 AK307826.1 BC136257.1 BC136258.1 BC143427.1 BX537946.1 L36644.1 

    4 DOTS entries:

    DT.65287326  DT.95152379  DT.407663  DT.95153288 

    Selected AceView cDNA sequences (see all 27):

    BM693322 BX642416 BX102577 AI867137 BE219686 BF433558 BX477839 H11658 
    BM664168 BE218107 D82015 AA121200 AV718336 D81888 AI697835 BX505546 
    T06040 T07343 AI694040 BG925074 AW341789 NM_182472 H12187 NM_004439 

    GeneLoc Exon Structure


    Expression
    for EPHA5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    EPHA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    EPHA5 Expression
    About this image


    EPHA5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Pancreas (Endocrine System)
             Mature Beta Cells Islets of Langerhans
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Peripheral Nervous System (Nervous System)
             Immature Schwann Cells Peripheral Nerve Domain
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor
    EPHA5 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    EPHA5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654492

    UniProtKB/Swiss-Prot: EPHA5_HUMAN, P54756
    Tissue specificity: Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje
    cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from
    the forebrain to hindbrain and spinal cord

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    Orthologs
    for EPHA5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for EPHA5 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Epha51 , 5 Eph receptor A51, 5 90.39(n)1
    96.24(a)1    		   5 (43.00 cM)5
    138391  NM_007937.31  NP_031963.21 
     840577915 
    chicken
    (Gallus gallus)    		 Aves EPHA51 EPH receptor A5 83.9(n)
    93.53(a)    		   395997  NM_205105.2  NP_990436.2 
    lizard
    (Anolis carolinensis)    		 Reptilia EPHA56
    		 EPH receptor A5
    		 93(a)
    		 1 ↔ 1
    		 GL343345.1(579409-856437)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia epha51 EPH receptor A5 78.14(n)
    86.68(a)    		   100488002  XM_002936460.2  XP_002936506.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC7975951 ephrin type-A receptor 5-like 72.52(n)
    79.67(a)    		   797595  XM_001338028.5  XP_001338064.4 


    ENSEMBL Gene Tree for EPHA5 (if available)
    TreeFam Gene Tree for EPHA5 (if available)

    Paralogs
    for EPHA5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for EPHA5 gene
    EPHB12  EPHA22  EPHB32  EPHA42  EPHB62  EPHA62  EPHA12  EPHB22  
    EPHA82  EPHA32  EPHA72  EPHA102  EPHB42  
    Selected SIMAP similar genes for EPHA5 using alignment to 5 protein entries:     EPHA5_HUMAN (see all proteins) (see all similar genes):
    EPHA3    EPHA4    EPHA6    EPHA7    EPHB1    EPHB2
    ABL1    EPHA8    EPHB2 variant protein    EPHA2    EPHB3    FGR
    FES    tec    EPHA10    FYN    SRC    MET

    Find genes that share paralogs with EPHA5           About GenesLikeMe



    Genomic Variants
    for EPHA5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for EPHA5 (see all 7811)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 4 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    VAR_0421434
    		A lung adenocarcinoma sample4--see VAR_0421432 G E mis40--------
    VAR_0421484
    		A lung large cell carcinoma sample4--see VAR_0421482 N S mis40--------
    VAR_0421424
    		A lung large cell carcinoma sample4--see VAR_0421422 E K mis40--------
    VAR_0421414
    		A lung adenocarcinoma sample4--see VAR_0421412 R Q mis40--------
    VAR_0421464
    		A lung squamous cell carcinoma sample4--see VAR_0421462 T I mis40--------
    rs58589651,2
    		C--62308692(+) TACAG-/T/TT  
                TTTTT     		2 -- int10--------
    rs712054021,2
    		C--62432188(+) AAAAA-/A/AAA 
                GTCCC     		2 -- int11NA 2
    rs58589801,2
    		C--62435386(+) aaaaa-/AAAAAA/AAAAAAAA
    AA    /AAAAAAAAAAAAAAA    CAGGA     		6 -- int1 cds11NA 2
    rs1811157901,2
    		--66184833(+) GACACA/GATACT 2 -- ds50010--------
    rs726402351,2
    		--66184947(+) TTGGGC/TTGATG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for EPHA5 (66185281 - 66435281 bp, first 250kb of EPHA5)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for EPHA5 (see all 32):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671686CNV Deletion23128226
    esv2727749CNV Deletion23290073
    esv2727748CNV Deletion23290073
    esv2727747CNV Deletion23290073
    esv2294940CNV Deletion18987734
    esv2501169CNV Deletion19546169
    esv2676800CNV Deletion23128226
    esv2021289CNV Deletion18987734
    esv2422517CNV Duplication17116639
    nsv291266CNV Insertion16902084

    Human Gene Mutation Database (HGMD): EPHA5
    Site Specific Mutation Identification with PCR Assays
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    Disorders / Diseases
    for EPHA5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 OMIM gene information: 600004    OMIM disorders: --

    1 disease for EPHA5:    
    About MalaCards
    drug psychosis

    1 inferred disease relationship from the University of Copenhagen DISEASES database for EPHA5:
    Drug psychosis

    Find genes that share disorders with EPHA5           About GenesLikeMe

    Genetic Association Database (GAD): EPHA5
    Human Genome Epidemiology (HuGE) Navigator: EPHA5 (1 document)

    Export disorders for EPHA5 gene to outside databases

    Publications
    for EPHA5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for EPHA5 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with EPHA5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PubMed id 9267020)1, 2, 3 (Cell 1997)
    2. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PubMed id 22174851)1, 4 Lingappa J.R....Goldstein D. (PLoS ONE 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Immunohistochemical localization of EphA5 in the adult human central nervous system. (PubMed id 10375373)1, 2 Olivieri G. and Miescher G.C. (J. Histochem. Cytochem. 1999)
    5. Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial tumors. (PubMed id 9191074)1, 2 Miescher G.C....Steck A.J. (Brain Res. Mol. Brain Res. 1997)
    6. cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. (PubMed id 7898931)1, 2 Fox G.M.... Welcher A.A. (Oncogene 1995)
    7. A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12. (PubMed id 7528718)1, 3 Spritz R.A....Moir D.T. (Genomics 1994)
    8. Frequent epigenetic inactivation of the receptor tyrosine kinase EphA5 by promoter methylation in human breast cancer. (PubMed id 19733895)1, 9 Fu D.Y....Shao Z.M. (Hum. Pathol. 2010)
    9. Functional activation of EphA5 receptor does not promote cell proliferation in the aberrant EphA5 expressing human glioblastoma U-118 MG cell line. (PubMed id 10064801)1, 9 Bruce V....Miescher G.C. (Brain Res. 1999)
    10. Regulation of topographic projection by the Eph family receptor Bsk (EphA5) and its ligands. (PubMed id 9321686)1, 9 Zhou R. (Cell Tissue Res. 1997)

    External Searches for EPHA5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  
      Query String
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    Genome Databases showing EPHA5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2044 HGNC: 3389 AceView: EPHA5 Ensembl:ENSG00000145242 euGenes: HUgn2044
    ECgene: EPHA5 Kegg: 2044 H-InvDB: EPHA5

    Other Databases showing EPHA5 gene

    (According to HUGE)
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    Specialized Databases showing EPHA5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for EPHA5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for EPHA5 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for EPHA5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for EPHA5 gene:
    Search GeneIP for patents involving EPHA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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