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EPHA5 Gene(Protein Coding)

EPH Receptor A5

GCID:
GC04M065319
GIFtS:
67
Genes Participants
UDN Logo

Aliases for EPHA5 Gene

Aliases for EPHA5 Gene

  • EPH Receptor A5 2 3 5
  • Brain-Specific Kinase 3 4
  • EPH Homology Kinase 1 3 4
  • EPH-Like Kinase 7 3 4
  • EC 2.7.10.1 4 63
  • TYRO4 3 4
  • EHK-1 3 4
  • EHK1 3 4
  • HEK7 3 4
  • EK7 3 4
  • Tyrosine-Protein Kinase Receptor EHK-1 3
  • Receptor Protein-Tyrosine Kinase HEK7 3
  • EC 2.7.10 63
  • EphA5 2
  • CEK7 3
  • BSK 4

External Ids for EPHA5 Gene

Previous GeneCards Identifiers for EPHA5 Gene

  • GC04U990011
  • GC04M066173
  • GC04M066193
  • GC04M066014
  • GC04M065872
  • GC04M062095

Summaries for EPHA5 Gene

Entrez Gene Summary for EPHA5 Gene

  • This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]

GeneCards Summary for EPHA5 Gene

EPHA5 (EPH Receptor A5) is a Protein Coding gene. Diseases associated with EPHA5 include Acrodermatitis Chronica Atrophicans and Drug-Induced Mental Disorder. Among its related pathways are Axon guidance and ERK Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is EPHA3.

UniProtKB/Swiss-Prot for EPHA5 Gene

  • Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity).

Tocris Summary for EPHA5 Gene

Gene Wiki entry for EPHA5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHA5 Gene

Genomics for EPHA5 Gene

Products:

  1. Regulatory Element

Regulatory Elements for EPHA5 Gene

Enhancers for EPHA5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around EPHA5 on UCSC Golden Path with GeneCards custom track

Promoters for EPHA5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EPHA5 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the EPHA5 gene promoter:

Genomic Location for EPHA5 Gene

Chromosome:
4
Start:
65,319,563 bp from pter
End:
65,670,495 bp from pter
Size:
350,933 bases
Orientation:
Minus strand

Genomic View for EPHA5 Gene

Genes around EPHA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPHA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPHA5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for EPHA5 Gene

Proteins for EPHA5 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for EPHA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54756-EPHA5_HUMAN
    Recommended name:
    Ephrin type-A receptor 5
    Protein Accession:
    P54756
    Secondary Accessions:
    • Q7Z3F2

    Protein attributes for EPHA5 Gene

    Size:
    1037 amino acids
    Molecular mass:
    114803 Da
    Quaternary structure:
    • Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).

    Three dimensional structures from OCA and Proteopedia for EPHA5 Gene

    Alternative splice isoforms for EPHA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPHA5 Gene

Proteomics data for EPHA5 Gene at MOPED

Protein Expression for EPHA5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for EPHA5 Gene

P54756:

Post-translational modifications for EPHA5 Gene

  • Phosphorylated. Phosphorylation is stimulated by the ligand EFNA5. Dephosphorylation upon stimulation by glucose, inhibits EPHA5 forward signaling and results in insulin secretion (By similarity).
  • Glycosylation at Asn 264, Asn 299, Asn 369, Asn 423, Asn 436, and Asn 461
  • Modification sites at PhosphoSitePlus

Other Protein References for EPHA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EPHA5 (EphA5)

Domains & Families for EPHA5 Gene

Gene Families for EPHA5 Gene

HGNC:
IUPHAR :

Protein Domains for EPHA5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for EPHA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P54756

UniProtKB/Swiss-Prot:

EPHA5_HUMAN :
  • Contains 1 Eph LBD (Eph ligand-binding) domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Domain:
  • Contains 1 Eph LBD (Eph ligand-binding) domain.
  • Contains 2 fibronectin type-III domains.
  • Contains 1 protein kinase domain.
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
genes like me logo Genes that share domains with EPHA5: view

Function for EPHA5 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for EPHA5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity).

Enzyme Numbers (IUBMB) for EPHA5 Gene

Gene Ontology (GO) - Molecular Function for EPHA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity IEA --
GO:0005003 ephrin receptor activity IEA,ISS --
GO:0005004 GPI-linked ephrin receptor activity IEA,ISS --
genes like me logo Genes that share ontologies with EPHA5: view

Phenotypes for EPHA5 Gene

MGI mutant phenotypes for EPHA5:
inferred from 1 alleles
GenomeRNAi human phenotypes for EPHA5:
genes like me logo Genes that share phenotypes with EPHA5: view

Animal Models for EPHA5 Gene

MGI Knock Outs for EPHA5:

Animal Model Products

miRNA for EPHA5 Gene

miRTarBase miRNAs that target EPHA5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EPHA5 Gene

Localization for EPHA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHA5 Gene

Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPHA5 Gene COMPARTMENTS Subcellular localization image for EPHA5 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
nucleus 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for EPHA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030425 dendrite IDA 10375373
GO:0043025 neuronal cell body IDA 10375373
genes like me logo Genes that share ontologies with EPHA5: view

Pathways & Interactions for EPHA5 Gene

genes like me logo Genes that share pathways with EPHA5: view

SIGNOR curated interactions for EPHA5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for EPHA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007411 axon guidance IEA,ISS --
GO:0032793 positive regulation of CREB transcription factor activity ISS --
GO:0048013 ephrin receptor signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with EPHA5: view

Drugs & Compounds for EPHA5 Gene

Products:

  1. Drug

(2) Drugs for EPHA5 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for EPHA5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with EPHA5: view

Transcripts for EPHA5 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for EPHA5 Gene

(11) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EPHA5 Gene

EPH receptor A5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EPHA5 Gene

No ASD Table

Relevant External Links for EPHA5 Gene

GeneLoc Exon Structure for
EPHA5
ECgene alternative splicing isoforms for
EPHA5

Expression for EPHA5 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for EPHA5 Gene

mRNA expression in normal human tissues for EPHA5 Gene
mRNA expression by BioGPS for EPHA5 GenemRNA expression by GTEx for EPHA5 Gene

mRNA differential expression in normal tissues according to GTEx for EPHA5 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.9), Brain - Hippocampus (x7.5), Brain - Anterior cingulate cortex (BA24) (x7.5), Brain - Amygdala (x5.7), and Brain - Cortex (x4.7).

Protein differential expression in normal tissues from HIPED for EPHA5 Gene

This gene is overexpressed in Fetal Brain (45.7) and Cerebrospinal fluid (19.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EPHA5 Gene



SOURCE GeneReport for Unigene cluster for EPHA5 Gene Hs.654492

mRNA Expression by UniProt/SwissProt for EPHA5 Gene

P54756-EPHA5_HUMAN
Tissue specificity: Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord.
genes like me logo Genes that share expression patterns with EPHA5: view

Protein tissue co-expression partners for EPHA5 Gene

Primer Products

Orthologs for EPHA5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EPHA5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia LOC100337226 35
  • 94.5 (n)
  • 97.77 (a)
EPHA5 36
  • 98 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia EPHA5 35
  • 95.32 (n)
  • 98.66 (a)
EPHA5 36
  • 98 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Epha5 35
  • 90.39 (n)
  • 96.24 (a)
Epha5 16
Epha5 36
  • 96 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia EPHA5 35
  • 99.58 (n)
  • 99.61 (a)
EPHA5 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Epha5 35
  • 91.1 (n)
  • 96.82 (a)
oppossum
(Monodelphis domestica)
 Mammalia EPHA5 36
  • 95 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia EPHA5 36
  • 95 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves EPHA5 35
  • 83.9 (n)
  • 93.53 (a)
EPHA5 36
  • 85 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia EPHA5 36
  • 93 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia epha5 35
  • 78.14 (n)
  • 86.68 (a)
zebrafish
(Danio rerio)
 Actinopterygii LOC797595 35
  • 72.52 (n)
  • 79.67 (a)
CT990561.1 36
  • 79 (a)
 OneToOne
Species with no ortholog for EPHA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EPHA5 Gene

ENSEMBL:
Gene Tree for EPHA5 (if available)
TreeFam:
Gene Tree for EPHA5 (if available)

Paralogs for EPHA5 Gene

Paralogs for EPHA5 Gene

(47) SIMAP similar genes for EPHA5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with EPHA5: view

Variants for EPHA5 Gene

Sequence variations from dbSNP and Humsavar for EPHA5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs33932471 - 65,643,367(+) CCCCA(G/T)TTTTT reference, missense
rs55710198 - 65,601,848(+) CACAG(A/C)AGGGC reference, missense
rs56205382 - 65,495,466(+) TTCCT(C/G)ATGGG intron-variant, reference, missense
VAR_042141 A lung adenocarcinoma sample
VAR_042142 A lung large cell carcinoma sample

Structural Variations from Database of Genomic Variants (DGV) for EPHA5 Gene

Variant ID Type Subtype PubMed ID
nsv879153 CNV Loss 21882294
dgv5570n71 CNV Loss 21882294
nsv879169 CNV Loss 21882294
nsv470041 CNV Loss 18288195
nsv509905 CNV Loss 20534489
esv993892 CNV Insertion 20482838
nsv507172 CNV Insertion 20534489
nsv879170 CNV Loss 21882294
nsv879171 CNV Loss 21882294
dgv5571n71 CNV Loss 21882294
esv2727747 CNV Deletion 23290073
esv2294940 CNV Deletion 18987734
nsv290967 CNV Loss 16902084
nsv818239 CNV Gain 17921354
nsv879174 CNV Loss 21882294
esv2676800 CNV Deletion 23128226
esv24754 CNV Loss 19812545
esv2727748 CNV Deletion 23290073
esv2727749 CNV Deletion 23290073
esv2501169 CNV Deletion 19546169
esv2021289 CNV Deletion 18987734
esv2671686 CNV Deletion 23128226
dgv5572n71 CNV Loss 21882294
esv2422517 CNV Duplication 17116639
nsv879180 CNV Loss 21882294
nsv291171 CNV Insertion 16902084
esv988089 CNV Insertion 20482838
esv1746107 CNV Insertion 17803354
nsv291266 CNV Insertion 16902084
nsv879181 CNV Loss 21882294
nsv879182 CNV Loss 21882294
dgv5573n71 CNV Loss 21882294

Variation tolerance for EPHA5 Gene

Residual Variation Intolerance Score: 6.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.77; 66.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EPHA5 Gene

Human Gene Mutation Database (HGMD)
EPHA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPHA5 Gene

Disorders for EPHA5 Gene

MalaCards: The human disease database

(7) MalaCards diseases for EPHA5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
acrodermatitis chronica atrophicans
  • herxheimer disease
drug-induced mental disorder
drug psychosis
  • drug-induced psychosis
lung large cell carcinoma
  • large cell carcinoma of lung
tick infestation
  • tick infestations
- elite association - COSMIC cancer census association via MalaCards
Search EPHA5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EPHA5

Genetic Association Database (GAD)
EPHA5
Human Genome Epidemiology (HuGE) Navigator
EPHA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EPHA5
genes like me logo Genes that share disorders with EPHA5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EPHA5 Gene

Publications for EPHA5 Gene

  1. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PMID: 9267020) (Cell 1997) 2 3 4 67
  2. Frequent epigenetic inactivation of the receptor tyrosine kinase EphA5 by promoter methylation in human breast cancer. (PMID: 19733895) Fu D.Y. … Shao Z.M. (Hum. Pathol. 2010) 3 23
  3. Functional activation of EphA5 receptor does not promote cell proliferation in the aberrant EphA5 expressing human glioblastoma U-118 MG cell line. (PMID: 10064801) Bruce V. … Miescher G.C. (Brain Res. 1999) 3 23
  4. Regulation of topographic projection by the Eph family receptor Bsk (EphA5) and its ligands. (PMID: 9321686) Zhou R. (Cell Tissue Res. 1997) 3 23
  5. A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12. (PMID: 7528718) Spritz R.A. … Moir D.T. (Genomics 1994) 2 3

Products for EPHA5 Gene

  • Addgene plasmids for EPHA5

Sources for EPHA5 Gene

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