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Aliases for EPHA5 Gene

Aliases for EPHA5 Gene

  • EPH Receptor A5 2 3
  • TYRO4 3 4 6
  • HEK7 3 4 6
  • Brain-Specific Kinase 3 4
  • EPH Homology Kinase 1 3 4
  • EPH-Like Kinase 7 3 4
  • EC 2.7.10.1 4 63
  • EHK-1 3 4
  • EHK1 3 4
  • EK7 3 4
  • Tyrosine-Protein Kinase Receptor EHK-1 3
  • Receptor Protein-Tyrosine Kinase HEK7 3
  • Ephrin Type-A Receptor 5 3
  • EC 2.7.10 63
  • EphA5 2
  • CEK7 3
  • BSK 4

External Ids for EPHA5 Gene

Previous GeneCards Identifiers for EPHA5 Gene

  • GC04U990011
  • GC04M066173
  • GC04M066193
  • GC04M066014
  • GC04M065872
  • GC04M062095

Summaries for EPHA5 Gene

Entrez Gene Summary for EPHA5 Gene

  • This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]

GeneCards Summary for EPHA5 Gene

EPHA5 (EPH Receptor A5) is a Protein Coding gene. Diseases associated with EPHA5 include drug psychosis. Among its related pathways are GPCR Pathway and Akt Signaling. GO annotations related to this gene include transmembrane-ephrin receptor activity and GPI-linked ephrin receptor activity. An important paralog of this gene is EPHB3.

UniProtKB/Swiss-Prot for EPHA5 Gene

  • Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity).

Gene Wiki entry for EPHA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHA5 Gene

Genomics for EPHA5 Gene

Regulatory Elements for EPHA5 Gene

Genomic Location for EPHA5 Gene

Start:
65,319,563 bp from pter
End:
65,670,811 bp from pter
Size:
351,249 bases
Orientation:
Minus strand

Genomic View for EPHA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EPHA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPHA5 Gene

Proteins for EPHA5 Gene

  • Protein details for EPHA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54756-EPHA5_HUMAN
    Recommended name:
    Ephrin type-A receptor 5
    Protein Accession:
    P54756
    Secondary Accessions:
    • Q7Z3F2

    Protein attributes for EPHA5 Gene

    Size:
    1037 amino acids
    Molecular mass:
    114803 Da
    Quaternary structure:
    • Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).

    Three dimensional structures from OCA and Proteopedia for EPHA5 Gene

    Alternative splice isoforms for EPHA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPHA5 Gene

Proteomics data for EPHA5 Gene at MOPED

Post-translational modifications for EPHA5 Gene

  • Phosphorylated. Phosphorylation is stimulated by the ligand EFNA5. Dephosphorylation upon stimulation by glucose, inhibits EPHA5 forward signaling and results in insulin secretion (By similarity).
  • Glycosylation at Asn264, Asn299, Asn369, Asn423, Asn436, and Asn461
  • Modification sites at PhosphoSitePlus

Domains for EPHA5 Gene

Gene Families for EPHA5 Gene

HGNC:
  • EPH :EPH receptors
  • FN3 :Fibronectin type III domain containing
  • SAMD :Sterile alpha motif (SAM) domain containing
IUPHAR :

Suggested Antigen Peptide Sequences for EPHA5 Gene

Graphical View of Domain Structure for InterPro Entry

P54756

UniProtKB/Swiss-Prot:

EPHA5_HUMAN :
  • P54756
Domain:
  • Contains 1 Eph LBD (Eph ligand-binding) domain.
  • Contains 2 fibronectin type-III domains.
  • Contains 1 protein kinase domain.
  • Contains 1 SAM (sterile alpha motif) domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
genes like me logo Genes that share domains with EPHA5: view

Function for EPHA5 Gene

Molecular function for EPHA5 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity).

Enzyme Numbers (IUBMB) for EPHA5 Gene

Gene Ontology (GO) - Molecular Function for EPHA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity --
GO:0005003 ephrin receptor activity ISS --
GO:0005004 GPI-linked ephrin receptor activity ISS --
GO:0005005 transmembrane-ephrin receptor activity NAS 7898931
genes like me logo Genes that share ontologies with EPHA5: view

Phenotypes for EPHA5 Gene

MGI mutant phenotypes for EPHA5:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with EPHA5: view

miRNA for EPHA5 Gene

miRTarBase miRNAs that target EPHA5

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for EPHA5 Gene

Localization for EPHA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHA5 Gene

Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EPHA5 Gene COMPARTMENTS Subcellular localization image for EPHA5 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for EPHA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005791 rough endoplasmic reticulum IDA 10375373
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0009897 external side of plasma membrane IDA 10064801
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with EPHA5: view

Pathways for EPHA5 Gene

genes like me logo Genes that share pathways with EPHA5: view

Pathways by source for EPHA5 Gene

Gene Ontology (GO) - Biological Process for EPHA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway --
GO:0007411 axon guidance TAS --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0019933 cAMP-mediated signaling ISS --
genes like me logo Genes that share ontologies with EPHA5: view

Compounds for EPHA5 Gene

(2) HMDB Compounds for EPHA5 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(1) Novoseek inferred chemical compound relationships for EPHA5 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 31.9 2
genes like me logo Genes that share compounds with EPHA5: view

Transcripts for EPHA5 Gene

Unigene Clusters for EPHA5 Gene

EPH receptor A5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EPHA5 Gene

No ASD Table

Relevant External Links for EPHA5 Gene

GeneLoc Exon Structure for
EPHA5
ECgene alternative splicing isoforms for
EPHA5

Expression for EPHA5 Gene

mRNA expression in normal human tissues for EPHA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EPHA5 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (7.9), Brain - Hippocampus (7.5), Brain - Anterior cingulate cortex (BA24) (7.5), Brain - Amygdala (5.7), and Brain - Cortex (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EPHA5 Gene

SOURCE GeneReport for Unigene cluster for EPHA5 Gene Hs.654492

mRNA Expression by UniProt/SwissProt for EPHA5 Gene

P54756-EPHA5_HUMAN
Tissue specificity: Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord.
genes like me logo Genes that share expressions with EPHA5: view

Orthologs for EPHA5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EPHA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EPHA5 35
  • 99.58 (n)
  • 99.61 (a)
EPHA5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EPHA5 36
  • 98 (a)
OneToOne
LOC100337226 35
  • 94.5 (n)
  • 97.77 (a)
dog
(Canis familiaris)
Mammalia EPHA5 35
  • 95.32 (n)
  • 98.66 (a)
EPHA5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Epha5 35
  • 90.39 (n)
  • 96.24 (a)
Epha5 16
Epha5 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EPHA5 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EPHA5 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Epha5 35
  • 91.1 (n)
  • 96.82 (a)
chicken
(Gallus gallus)
Aves EPHA5 35
  • 83.9 (n)
  • 93.53 (a)
EPHA5 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EPHA5 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia epha5 35
  • 78.14 (n)
  • 86.68 (a)
zebrafish
(Danio rerio)
Actinopterygii CT990561.1 36
  • 79 (a)
OneToOne
LOC797595 35
  • 72.52 (n)
  • 79.67 (a)
Species with no ortholog for EPHA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EPHA5 Gene

ENSEMBL:
Gene Tree for EPHA5 (if available)
TreeFam:
Gene Tree for EPHA5 (if available)

Paralogs for EPHA5 Gene

Paralogs for EPHA5 Gene

genes like me logo Genes that share paralogs with EPHA5: view

Variants for EPHA5 Gene

Sequence variations from dbSNP and Humsavar for EPHA5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs459790 -- 65,505,992(+) CTATC(C/T)CTCCC intron-variant
rs745237 -- 65,397,293(+) tcccc(A/T)ctcct intron-variant
rs896214 -- 65,405,097(+) AGAAA(A/C)CTATC intron-variant
rs896215 -- 65,405,195(+) TAAGA(G/T)GAATA intron-variant
rs896216 -- 65,405,616(+) CAGTA(G/T)TTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EPHA5 Gene

Variant ID Type Subtype PubMed ID
nsv879153 CNV Loss 21882294
dgv5570n71 CNV Loss 21882294
nsv879169 CNV Loss 21882294
nsv470041 CNV Loss 18288195
nsv509905 CNV Loss 20534489
esv993892 CNV Insertion 20482838
nsv507172 CNV Insertion 20534489
nsv879170 CNV Loss 21882294
nsv879171 CNV Loss 21882294
dgv5571n71 CNV Loss 21882294
esv2727747 CNV Deletion 23290073
esv2294940 CNV Deletion 18987734
nsv290967 CNV Loss 16902084
nsv818239 CNV Gain 17921354
nsv879174 CNV Loss 21882294
esv2676800 CNV Deletion 23128226
esv24754 CNV Loss 19812545
esv2727748 CNV Deletion 23290073
esv2727749 CNV Deletion 23290073
esv2501169 CNV Deletion 19546169
esv2021289 CNV Deletion 18987734
esv2671686 CNV Deletion 23128226
dgv5572n71 CNV Loss 21882294
esv2422517 CNV Duplication 17116639
nsv879180 CNV Loss 21882294
nsv291171 CNV Insertion 16902084
esv988089 CNV Insertion 20482838
esv1746107 CNV Insertion 17803354
nsv291266 CNV Insertion 16902084
nsv879181 CNV Loss 21882294
nsv879182 CNV Loss 21882294
dgv5573n71 CNV Loss 21882294

Relevant External Links for EPHA5 Gene

HapMap Linkage Disequilibrium report
EPHA5
Human Gene Mutation Database (HGMD)
EPHA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPHA5 Gene

Disorders for EPHA5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for EPHA5 Gene including...

Search for EPHA5 Gene in MalaCards »

(1) University of Copenhagen DISEASES for EPHA5 Gene

Relevant External Links for EPHA5

Genetic Association Database (GAD)
EPHA5
Human Genome Epidemiology (HuGE) Navigator
EPHA5
genes like me logo Genes that share disorders with EPHA5: view

No data available for UniProtKB/Swiss-Prot for EPHA5 Gene

Publications for EPHA5 Gene

  1. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. (PMID: 9267020) (Cell 1997) 2 3 4
  2. Frequent epigenetic inactivation of the receptor tyrosine kinase EphA5 by promoter methylation in human breast cancer. (PMID: 19733895) Fu D.Y. … Shao Z.M. (Hum. Pathol. 2010) 3 23
  3. A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12. (PMID: 7528718) Spritz R.A. … Moir D.T. (Genomics 1994) 2 3
  4. cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. (PMID: 7898931) Fox G.M. … Welcher A.A. (Oncogene 1995) 3 4
  5. Regulation of topographic projection by the Eph family receptor Bsk (EphA5) and its ligands. (PMID: 9321686) Zhou R. (Cell Tissue Res. 1997) 3 23

Products for EPHA5 Gene

  • Addgene plasmids for EPHA5

Sources for EPHA5 Gene

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