EPHA3 Gene
protein-coding GIFtS : 67 GCID: GC03 P089239
EPH receptor A3 EphA3 )ETK, ETK1, TYRO4 )
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Aliasesfor EPHA3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases EPH Receptor A3 1 2 EC 2.7.10.13 8 ETK11 2 3 5 EphA31 HEK1 2 3 5 Ephrin Type-A Receptor 32 ETK1 2 3 Human Embryo Kinase 12 TYRO41 2 3 TYRO4 Protein Tyrosine Kinase2 HEK41 2 HEK41 2 Eph-Like Tyrosine Kinase 12 3 Human Embryo Kinase3 Tyrosine-Protein Kinase Receptor ETK12 3 Tyrosine-Protein Kinase TYRO43 EK42 3 EC 2.7.108 EPH-Like Kinase 42 3
Export aliases for EPHA3 gene to outside databases Previous GC identifers: GC03P089525 GC03P092010 GC03P089036 GC03P089077
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Summariesfor EPHA3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for EPHA3 : This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320 Function : Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacentcells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development Gene Wiki entry for EPHA3 (EPH receptor A3)
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Genomic Viewsfor EPHA3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000003.11 NC_018914.1 NT_022459.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the EPHA3 gene promoter:AP-1 HTF ATF-2 IRF-7A STAT3 c-Jun Other transcription factors Search SABiosciences Chromatin IP Primers for EPHA3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat EPHA3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3p11.2 Ensembl cytogenetic band: 3p11.1 HGNC cytogenetic band: 3p11.2 EPHA3 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03P089239: view genomic region
(about GC identifiers )
Start: 89,156,674 bp from pter End:
89,531,284 bp from pter
Size: 374,611 bases Orientation:
plus strand
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Proteinsfor EPHA3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320 See
protein sequence )Recommended Name: Size : 983 amino acids; 110131 DaSubunit : Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptordimer. Oligomerization is probably required to induce biological responses. Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function. Interacts with NCK1 (via SH2 domain); mediates EFNA5-EPHA3 signaling (By similarity). Interacts (phosphorylated) with PTPN1; dephosphorylates EPHA3 and may regulate its trafficking and function. Interacts (phosphorylated) with CRK; mediates EFNA5-EPHA3 signaling through RHOA GTPase activation
Subcellular location : Isoform 1: Cell membrane; Single-pass type I membrane proteinSubcellular location : Isoform 2: Secreted6/21 PDB 3D structures from (see all 21 ):2GSF (3D) 2QO2 (3D) 2QO7 (3D) 2QO9 (3D) 2QOB (3D) 2QOC (3D) Secondary accessions : Q9H2V3 Q9H2V4Alternative splicing : 2 isoforms : P29320-1 P29320-2 Explore the universe of human proteins at neXtProt for EPHA3: NX_P29320 Post-translational modifications:
Autophosphorylates upon activation by EFNA5. Phosphorylation on Tyr-602 mediates interaction with NCK1. Dephosphorylated by PTPN11
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P29320 4/62 DME Specific Peptides for EPHA3 (P29320 ) (see all 62 )EPHA3 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (2 alternative transcripts): NP_005224.2 NP_872585.1 ENSEMBL proteins: ENSP00000337451 ENSP00000399926 ENSP00000419190 Human Recombinant Protein Products for EPHA3: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing EPHA3 Antibody Products: Assay Products for EPHA3:
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Protein
Domains /for EPHA3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/16 InterPro domains/families (see all 16 ):
Graphical View of Domain Structure for InterPro Entry P29320 ProtoNet protein and cluster: P29320
5/6 Blocks protein families (see all 6 ): IPB001090 IPB001426 IPB001660 IPB003962 IPB008266 UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320 Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamilySimilarity : Contains 1 Eph LBD (Eph ligand-binding) domainSimilarity : Contains 2 fibronectin type-III domainsSimilarity : Contains 1 protein kinase domainSimilarity : Contains 1 SAM (sterile alpha motif) domain
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Functionfor EPHA3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: EPHA3_HUMAN, P29320 Function : Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacentcells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development Catalytic activity : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Genatlas biochemistry entry for EPHA3 EPH-related tyrosine kinase receptor binding ephrins A,expressed in projecting neurons and their target fields,involved in short-range contact-mediated axonal guidance,expressed by some pre-B and T cell lines,not detectable on normal adult human tissues Enzyme Numbers (IUBMB): EC 2.7.10.1 1 2 EC 2.7.10 2 Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for EPHA3 :6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Epha3) :About GeneDecksing Animal Models: Epha3 tm1Abn for EPHA3Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 6 )human mouse rat see all 3 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): EPHA3 (NM_005233 ) Sino Biological Human cDNA Clone for EPHA3 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EPHA3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat EPHA3
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA3
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Pathways & Interactionsfor EPHA3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/19 super-pathways (see all 19 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 GPCR Pathway 2 Rho Family GTPases 3 Nanog in Mammalian ESC Pluripotency 4 Actin Nucleation by ARP-WASP Complex 5 G-protein signaling_RhoA regulation pathway
Pathway sources See GeneCards unified pathways Show all pathways 3 5/32 (see all 32 )1 3 2 1 (Kegg details for EPHA3) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for EPHA3 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/37 Interacting proteins for EPHA3 (P29320 2 , 3 ENSP00000337451 4 via UniProtKB, MINT, STRING , and/or I2D (see all 37 )About this table Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16 ): About this table
About GeneDecksing
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Drugs & Compoundsfor EPHA3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for EPHA3 2 HMDB Compounds for EPHA3 About this table 10/48 Novoseek chemical compound relationships for EPHA3 gene (see all 48 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
tab-1
73.8
4
11745395 (1), 17052891 (1), 17932218 (1), 19531477 (1)
threonine
65.1
24
16641196 (1), 19966577 (1), 20416281 (1), 9405407 (1) (see all 23 )
pd 98,059
59.7
10
18778461 (1), 10925306 (1), 12628005 (1), 14690534 (1) (see all 9 )
tyrosine
57.3
21
1334998 (2), 8188238 (2), 15151996 (1), 18762249 (1) (see all 18 )
serine
55
22
16641196 (1), 19966577 (1), 20416281 (1), 9405407 (1) (see all 22 )
cl 100
52.7
1
15030167 (1)
sb 203580
50.5
2
18778461 (1), 12589827 (1)
phosphatidylinositol
48.8
5
14633175 (1), 16322251 (1), 11382770 (1), 12589827 (1) (see all 5 )
phosphoinositide
46.6
8
15468165 (1), 16885398 (1), 16895519 (1), 19920184 (1) (see all 8 )
sp 600125
38.5
3
18778461 (1), 15670787 (1), 12589827 (1)
EPHA3
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Transcriptsfor EPHA3 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for EPHA3 gene (2 alternative transcripts): NM_005233.5 NM_182644.2 Unigene Cluster for EPHA3:
EPH receptor A3 Hs.123642 [show with all ESTs ] Unigene Representative Sequence: NM_005233 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000336596 (uc021xbf.1 uc003dqy.3 ) ENST00000452448 (uc003dqx.1 )ENST00000494014 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 6 )human mouse rat see all 3 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): EPHA3 (NM_005233 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for EPHA3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat EPHA3
Additional cDNA sequence: AF213459.1 AF213460.1 AK024352.1 AK291411.1 BC026247.1 BC063282.1 HM437236.1 M83941.1
4 DOTS entries : DT.97837000 DT.208723
DT.40125530 DT.100662313 24/45 AceView cDNA sequences (see all 45 ):
BC063282 AI741389 AL042479 AF213459 NM_182644 AF213460 T28603 BC026247 AU120483 AU137594 NM_005233 AK024352 AI918950 BE327884 AI824661 BF194844 D81814 M85652 BQ003325 AI590014 BG572424 BX441974 AU136712 BG033947 GeneLoc Exon Structure
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Expression for EPHA3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section EPHA3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: -- About this image EPHA3 expression in embryonic tissues and stem cells About this table
See EPHA3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for EPHA3 SOURCE GeneReport for Unigene cluster: Hs.123642 UniProtKB/Swiss-Prot: EPHA3_HUMAN, P29320 Tissue specificity : Widely expressed. Highest level in placentaSABiosciences Custom PCR Arrays for EPHA3 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for EPHA3
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Orthologsfor EPHA3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for EPHA3 gene from 5/22 species (see all 22 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves EPHA31
EPH receptor A3
81.98(n) 91.9(a)
396402 NM_205430.1 NP_990761.1
lizard Reptilia EPHA36
--
88(a)
1 ↔ 1
3(166700230-166879358)
zebrafish Actinopterygii epha3l6 6 see all 3 )
--
83(a) 31(a) (see all 3 )
1 ↔ 1possible ortholog(see all 3 )
9(16828231-16919914) Zv9_NA779(312-23840)
fruit fly Insecta Eph3
protein amino acid phosphorylationmore
40(a)
102C2 --
worm Secernentea W04G5.103
--
35(a)
I(11646625-11648468) --
ENSEMBL Gene Tree for EPHA3 (if available)TreeFam Gene Tree for EPHA3 (if available)
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Paralogsfor EPHA3 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for EPHA3 gene EPHB1 2 EPHA2 2 EPHB3 2 EPHA4 2 EPHA5 2 EPHB6 2 EPHA6 2 EPHB2 2 EPHA1 2 EPHA8 2 EPHA7 2 EPHB4 2 EPHA10 2 18/47 SIMAP similar genes for EPHA3 using alignment to 4 protein entries: EPHA3_HUMAN (see all proteins )
(see all similar genes ):EPHA6 EPHA4 EPHA7 EPHA5 EPHB1 EPHB2 variant protein EPHA8 EPHB2 EPHB3 EPHA2 ABL1 FGR EPHA10 FES FYN EPHB4 SRC HCK About GeneDecksing
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Genomic Variantsfor EPHA3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 3 pos Sequence # AA Type More # Allele Pop Total More
and Proteopedia 
for EPHA3 (
BioSystems Pathways for EPHA3 
Kegg Pathway 
Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Curated
